<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD6</accession>
    <name>C6WZD6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782114.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00509"/>
    <dbReference type="EnsemblBacteria" id="ACU06967">
        <property type="protein sequence ID" value="ACU06967"/>
        <property type="gene ID" value="FIC_00509"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00509"/>
    <dbReference type="HOGENOM" id="CLU_2584592_0_0_10"/>
    <dbReference type="OrthoDB" id="2062395at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973262" evidence="2">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="77" mass="8383" checksum="6EEF9C343C600053" modified="2009-09-22" version="1">MTRSNLLTKIKFFAAALVLNFATLLVTAQEKAADFSVEAGETQDQGAETFPSNPILLVVFALVAITILIFVIKGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE1</accession>
    <name>C6WZE1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ordered locus">FIC_00514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00514"/>
    <dbReference type="EnsemblBacteria" id="ACU06972">
        <property type="protein sequence ID" value="ACU06972"/>
        <property type="gene ID" value="FIC_00514"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00514"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_0_10"/>
    <dbReference type="OMA" id="VRNFENL"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="27079" checksum="1A9DFAE6B7D009E4" modified="2009-09-22" version="1">MSQIKPYNTDAGKKREVEEMFDNIAPKYDLLNHVLSMKIDMLWRNTLVKWMLQDAPKVVLDVATGTGDLAVAVQKGTGAKVVGLDLSQQMLNVGIEKIRKQNLQEEISMQKGDAENLPFESNKFDAVCVAFGVRNFENLEKGLAELSRVVKENKSVYILEFSKVEGFLGPFYMFYFKNILPLIGRLVSKDNRAYTYLPDSVNAFPFGEKMKNILLNTGFRKVEYKKLSLGIATIYKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE9</accession>
    <name>C6WZE9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein FIC_00006</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781631.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00006"/>
    <dbReference type="EnsemblBacteria" id="ACU06484">
        <property type="protein sequence ID" value="ACU06484"/>
        <property type="gene ID" value="FIC_00006"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00006"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_2_1_10"/>
    <dbReference type="OMA" id="RNWRCGR"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="123" mass="14183" checksum="A18B3B7E48231DEF" modified="2009-09-22" version="1">MADHNDFGKLAEDLAADFLARKNYRILARNFRYQKAEIDIIAQFQEVIVIVEVKARSYDTLIEPQEAVTKKKIKSIVLCADFYMQQSNIDREVRFDIITVLPDKSGALQINHIEDAFQSFDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL5</accession>
    <name>C6WZL5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00074"/>
    <dbReference type="EnsemblBacteria" id="ACU06550">
        <property type="protein sequence ID" value="ACU06550"/>
        <property type="gene ID" value="FIC_00074"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00074"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2716507_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="72" mass="8630" checksum="7D30A3DA90035278" modified="2009-09-22" version="1">MGVSVSKKYFKKAVDRNRIKRLLREMYRHNKAEFSARFGEHSLSMIFWVSKEMPPDFETLQQNFLTLCNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP9</accession>
    <name>C6WZP9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ordered locus">FIC_00109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781731.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00109"/>
    <dbReference type="EnsemblBacteria" id="ACU06584">
        <property type="protein sequence ID" value="ACU06584"/>
        <property type="gene ID" value="FIC_00109"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00109"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_3_2_10"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="143" mass="15957" checksum="4BAA4B19CF110852" modified="2009-09-22" version="1">MFTDEYYMKIALQEAQQALEKDEVPIGCIIVSNNRIIAKAHNLTEALNDVTAHAEMQAITSAANYLGGKYLQNCTLYVTLEPCVMCCGALSWSQISKVVIGARDEQRGFINKNLSIHPKTEIVLGVLENECSQLVKDFFKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZX8</accession>
    <name>C6WZX8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-1,3-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00188"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06663">
        <property type="protein sequence ID" value="ACU06663"/>
        <property type="gene ID" value="FIC_00188"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00188"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_3_10"/>
    <dbReference type="OMA" id="ARMIVNC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="361" mass="41673" checksum="F11E5C151C6B248E" modified="2009-09-22" version="1">MRLHCCAGFIKSGRSARIIIFTEKFKQMVKVSVIVPVYQGEKELSKCLASLVNQTLDDIEIIVVNDGSTDGSGEIITEFSQRFPSKIRAFTKENGGLSDARNFGLDRATGQYIGFVDADDEVSANTFAEMYELAEKHAAEMVICNIQKVDEAGKITQKLTQIPNMPERIVLEDHFSVFADISYFACNKIFRKDILHNKRFKKGIHYEDIQLIPQLLLECRVIAQTQNYHYQYFERRGSITKTHTEKGLDILRAVADVENAFATSQYSHQKAGLRNFQILEGIYSFLAYLAFVKDEKISRKLSDELKKFRQQRGIGWLEIIRYQRFGKNYLLYLPTRKKIYYLLYFMGQEALLRKLAKNTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ8</accession>
    <name>C6WZZ8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781830.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00209"/>
    <dbReference type="EnsemblBacteria" id="ACU06683">
        <property type="protein sequence ID" value="ACU06683"/>
        <property type="gene ID" value="FIC_00209"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00209"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_5_2_10"/>
    <dbReference type="OMA" id="AYFFMIR"/>
    <dbReference type="OrthoDB" id="2082059at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="109" mass="12181" checksum="9A9BF287A9D5A463" modified="2009-09-22" version="1">MISIFLQAAAPESTMMPTMIMMGLMFVGFYFLMIRPQMKKAKQEKGFQAALKVGSRVVTTSGMHGRIAQIMEDGVVIETLSGKLKFEKAAISREFTQQRFPDSAPDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X040</accession>
    <name>C6X040_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781872.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00252"/>
    <dbReference type="EnsemblBacteria" id="ACU06725">
        <property type="protein sequence ID" value="ACU06725"/>
        <property type="gene ID" value="FIC_00252"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00252"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108463_0_0_10"/>
    <dbReference type="OMA" id="EMTIHIN"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972158" description="YceI domain-containing protein" evidence="1">
        <location>
            <begin position="41"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="40"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="193" mass="20739" checksum="05962B7E1BA76DDC" modified="2009-09-22" version="1">MPHLICRKQVQKQLNIKKMKNSFKSLLVMFAVAMFGFVNAQNITGKSTKVSVDGTSPMHDWTMTASAANFSGKVNGNTITNVKFSMPVKNLKSTKGKMMDNKAYDALNADKNPNISFSAATLNMGKSNLAGKLTIAGVTKDISFPVTVTKNGASYHIIGSENIKLSDFGLARPGFMGVKTGDAMKVTVHITAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K1</accession>
    <name>C6X0K1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00420"/>
    <dbReference type="EnsemblBacteria" id="ACU06887">
        <property type="protein sequence ID" value="ACU06887"/>
        <property type="gene ID" value="FIC_00420"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00420"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494952_0_0_10"/>
    <dbReference type="OMA" id="LIECYSY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972177" evidence="2">
        <location>
            <begin position="43"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="569" mass="62742" checksum="BC7C32EE3BF039AB" modified="2009-09-22" version="1">MGFKIRNVFLKFNKLKSNIIMNVSKKVALGIATVFFSNFAFAQTLQEGIASADSHKYAKAKSVFNEMIVKSPSAENYFYLGNSYLTQFEPNFDLAQENFNKGLAADKKSNLNRIGLASVKLGKGDKSAVTEIQNIVKDSRDKDPEVLYRAAEALTLFGGAGNADLAIDYLNRAVDKSQKGGTPANYYYTLGDAYRLKLTNSPQVAGSAMTAYDKALPVAKNKASVYTRIGTLWMQAQQWQKAKESIDRAIAADPTYAPAYKAKAAYSIKYQQNALATQDLLNYAKYADEDPDTQLEISKLFFTNEDYANSKTYLDKVFDKVNDPIKFKLRAYLLYADGDYPGAKASMDQFISKAEKTRVQPADQGLLGLVSAGLAEKETDAAKKASLMADAQQKIALAKNAKDETMNWDLELVKIKGGGGVTQAAVEAGPTNPQIEQLKKEVAEKPQDTDALFRLANAYQEAENWNGAILTWQKMSGLLPDWAPAYYSQGYAYQQAGNSELAKIAYEKFISTVKPADREANKEILSYAYFAVAYLVKDSDPVKAKNYASQSVQLNPGYQDAVNLNNSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N8</accession>
    <name>C6X0N8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">FIC_00462</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782071.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00462"/>
    <dbReference type="EnsemblBacteria" id="ACU06924">
        <property type="protein sequence ID" value="ACU06924"/>
        <property type="gene ID" value="FIC_00462"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00462"/>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_3_10"/>
    <dbReference type="OMA" id="RDPYRVW"/>
    <dbReference type="OrthoDB" id="1274533at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="DNA_Glycosylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005760">
        <property type="entry name" value="A/G_AdeGlyc_MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01084">
        <property type="entry name" value="mutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="14">
        <location>
            <begin position="45"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU06924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="372" mass="42915" checksum="50D2914F094B25AD" modified="2009-09-22" version="1">MTSKKQNADFLHVGENLLAWYNTHGRDLPFRKTGDPYRIWVCEIIFQQTRIAQGLNHYQNFIARFPDVHTLANAETDEVLLYWKGLGYYSRALNLHKAAMQIIHEYGGIFPKNYDDILKLRGVGKYTAAAIASICFGAHIPAVDGNFYRVLSRVFAEDFDVSNSKAFNYFSGLALRMMPQNKAGHFNEAMMDLGSEVCRPRNPKCEICPLNADCLAFNLGLIPKFPVKTKKTKPTDLELTYYFVEFGERFLIRQRNEDHIWKKLFEFPIRIPENFKQDITHHKTVSHQLTHKNLTIHIYKVTLIAENAFLEFALKENLQIITLEDSHHKSFPKPLQNYLARFNLASENHSNGKAESPRSVLNGVWESSELND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Q9</accession>
    <name>C6X0Q9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782092.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00486"/>
    <dbReference type="EnsemblBacteria" id="ACU06945">
        <property type="protein sequence ID" value="ACU06945"/>
        <property type="gene ID" value="FIC_00486"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00486"/>
    <dbReference type="eggNOG" id="ENOG502Z8IK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504989_0_0_10"/>
    <dbReference type="OMA" id="WIINEAN"/>
    <dbReference type="OrthoDB" id="1496175at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025366">
        <property type="entry name" value="DUF4270"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14092">
        <property type="entry name" value="DUF4270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="517" mass="56906" checksum="F9D0CD69284D1D9F" modified="2009-09-22" version="1">MIKDIKKLLNITATLVIGSLILWNCEPDADQLGSQFFQDGAEGTQTPYDIIAFNVNNGDTIRTDASRLQSATLGAFRESQFGLQKSAYVSQVRLSSYNPDFGANAVIDSAVMVINPSYATDSIKTTTTEDYIYPDGAVPAKKVVNTFPVLKYGRTKVNEKTVFNIKVHEVTDFLYANTDKVYSNKTAAVGSVIGSKVFNGDISAIKITKDTDNSDLYIREATLRIPMDSAFFQNKIITKGGSGELTDAASFIRYFRGIKISVDENDGYLFNFDPNSVVINLYYKKDRVTDGVTTREQVVYPLDLGSANTHFSEITFDRAGTPSAAIATPLTAQDTLQGQPKIFAQGMGGPGFGLKIPEATIAAIKDLYNTEKIGIISAKLRVYTDTESWSNNYKKPNYFVVKQKNLKTYLEDMTALAYTSAYSLVKGYDLDKNPGYYDIGVTQTFKNIIEKEVPARSFILNVGTYTSDATGNLAGLQDPTMAQYYNTRAYTPNRVVLVGTQPGNEKSAKLILTYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0R1</accession>
    <name>C6X0R1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GldJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782094.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00488"/>
    <dbReference type="EnsemblBacteria" id="ACU06947">
        <property type="protein sequence ID" value="ACU06947"/>
        <property type="gene ID" value="FIC_00488"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00488"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_10_1_10"/>
    <dbReference type="OMA" id="YPWGGPY"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019866">
        <property type="entry name" value="Glid_motil-assoc_lipo_GldK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03525">
        <property type="entry name" value="GldK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="471" mass="53188" checksum="DD4D06A644F81C27" modified="2009-09-22" version="1">MKRIFLIILSASVVISCSKGGGASAGKPGMKGELVPKGKAKSFVAERPYGMVAIPAGSYVMGLADQDFTNTPEKATLKTVTVSSFFMDETEITNAEYRVFINYVRDSVARSLLAEAAGDGGSDGDGTSIGDFAYASKKAGEDKTAYQEFMESQGGRDGYDESKKLDWSVPLQWRTSDYPDAQYAEILESMYIPPAERINNERIIDSRKLLYAYNWEDIESAVKDKSRGAKYLKKESIAVYPDTTVWIRDFNYAYNEPLYDGYFWHSAYKNYPVVGVTWDQARAYCNFKSKLKSDYNESLKKKKQKPMAFRLPTEAEWEYAARGGRENATYPWGGPYLQDDRGCYLANFKPKRGNYIEDEKKGTYTYTAPVKQFEKNGFGLFDMAGNVAEWTESPYNNATYQFASTLNPNLSNVAYREVRKSVRGGSWKDVGYLLMNGARDYERKDSARSFIGFRTVQDIPEGTAKFKKRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0T4</accession>
    <name>C6X0T4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01601"/>
    <dbReference type="EnsemblBacteria" id="ACU08047">
        <property type="protein sequence ID" value="ACU08047"/>
        <property type="gene ID" value="FIC_01601"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01601"/>
    <dbReference type="HOGENOM" id="CLU_3251864_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="42" mass="4662" checksum="BE2BD18C1179ED9E" modified="2009-09-22" version="1">MVGTISLIVFGTIFTFGEGKINGHEKIITNCKRSFAGFHNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0U0</accession>
    <name>C6X0U0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806338.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01607"/>
    <dbReference type="EnsemblBacteria" id="ACU08053">
        <property type="protein sequence ID" value="ACU08053"/>
        <property type="gene ID" value="FIC_01607"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01607"/>
    <dbReference type="HOGENOM" id="CLU_2206160_0_0_10"/>
    <dbReference type="OMA" id="ANSHTTW"/>
    <dbReference type="OrthoDB" id="2027364at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="107" mass="12968" checksum="6E61DAE47F4E1687" modified="2009-09-22" version="1">MEKTIIFSQAFHQSIEELIYVLYAKKYFGFKTDSHAYAQKIYDFISINVTMPNSRKSPFNFQQYGKKYIKYKANSHTTWYIFFDQKGDRFVINYILNNHSQEYPELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X3</accession>
    <name>C6X0X3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01641"/>
    <dbReference type="EnsemblBacteria" id="ACU08086">
        <property type="protein sequence ID" value="ACU08086"/>
        <property type="gene ID" value="FIC_01641"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01641"/>
    <dbReference type="HOGENOM" id="CLU_3373900_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="34" mass="4041" checksum="B6E18517874DB0A1" modified="2009-09-22" version="1">MPFCKNNYFCISKTIKTAHFVKSEVPQQHLKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y8</accession>
    <name>C6X0Y8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806386.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01657"/>
    <dbReference type="EnsemblBacteria" id="ACU08101">
        <property type="protein sequence ID" value="ACU08101"/>
        <property type="gene ID" value="FIC_01657"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01657"/>
    <dbReference type="eggNOG" id="COG2738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084406_0_0_10"/>
    <dbReference type="OMA" id="VQHATAY"/>
    <dbReference type="OrthoDB" id="1656873at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="235" mass="25695" checksum="14E08E6F0D07A470" modified="2009-09-22" version="1">MTGYYVIIGISMLVSWLVSARLKSKFEHYSKVHLRNGMSGKEVAEKMLRDNSIQDVKVISVPGQLTDHYNPADKTVNLSEGVYMQRNAAAAAVAAHECGHAVQHAVGYSMLQLRSKLVPMVSISSNLMQFVLIAGIVLMGATRTIENPNGNTTVLAIGVAMFALTTLFAFVTLPVEYDASNRAMKWLKDTGTVTAEEYVGVKDSLTWAARTYLVAALGSLAQLLYWASMLMGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X108</accession>
    <name>C6X108_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HRDC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806406.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01677"/>
    <dbReference type="EnsemblBacteria" id="ACU08121">
        <property type="protein sequence ID" value="ACU08121"/>
        <property type="gene ID" value="FIC_01677"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01677"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137324_0_0_10"/>
    <dbReference type="OMA" id="FGKHKIE"/>
    <dbReference type="OrthoDB" id="1951125at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="17545" checksum="0DC4A4B20C6A9317" modified="2009-09-22" version="1">MNVKILKVRLSDQYIYTDQRALDRFLQQNNVIRFESAFVKDEEAYWSVILYYEDTKMTVNESKNQKYSADTDEELNPDEIKILESLKLWRSEKAKNQNLPVYFIATNNELLSIAKYKPAKKEELCGIKGFGKHKIEHYGEEIIGILEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X114</accession>
    <name>C6X114_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806412.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01684"/>
    <dbReference type="EnsemblBacteria" id="ACU08127">
        <property type="protein sequence ID" value="ACU08127"/>
        <property type="gene ID" value="FIC_01684"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01684"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_10"/>
    <dbReference type="OMA" id="VPGEPYM"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="314" mass="35769" checksum="2B998A217A77CE5F" modified="2009-09-22" version="1">MLLEIRNLYFSYTADKKLFQNLNLSVEQGRTIALTGESGCGKSTLLSLVYGLLDWDEGEIIFDGKAVYGPKKNIVPGESEMKLVAQNYDLMPYATVADNVGKFISNINLKVKKERVHELLDVVGLTDYAGVLPKFLSGGQQQRVAIARALSVMPKLLLLDEPFSNLDFPRKIELREKLFSYVKQKNISLIVSTHEIQEVMPWLDQIIVLKEGRLIQNDTPAETYRNPYNDYVARLFGEVNVFTDVDAAILELPSMIYYPHQITISDEGLEAEVKESRFAGSYYWNKLVLKGVNMVVYTDHQLESKVNITFRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X152</accession>
    <name>C6X152_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806450.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01722"/>
    <dbReference type="EnsemblBacteria" id="ACU08165">
        <property type="protein sequence ID" value="ACU08165"/>
        <property type="gene ID" value="FIC_01722"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01722"/>
    <dbReference type="eggNOG" id="ENOG5031DC5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129317_0_0_10"/>
    <dbReference type="OMA" id="WADSQAF"/>
    <dbReference type="OrthoDB" id="1476471at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021354">
        <property type="entry name" value="DUF2975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11188">
        <property type="entry name" value="DUF2975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="178" mass="20070" checksum="B2AA7FBD48EE363C" modified="2009-09-22" version="1">MSKTDNTVFIVLQVVAWIIFVGLSIEAGGLIVNFIFSLYKPEVVQNLYNKLDLSEMYAHSRRAYYGMYSFAIAVSLLKAVMFYHVITLLSTLKLTNPFTVLVSKQIYTISYYTLSIGLLSYLARQSAQKLQHAGIDTSNLNEYWADSQAFVLMAAVIYAIAAIFKKGIELQDEHDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X169</accession>
    <name>C6X169_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-mannonate oxidoreductase</fullName>
            <ecNumber evidence="1">1.1.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.57" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806467.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01739"/>
    <dbReference type="EnsemblBacteria" id="ACU08182">
        <property type="protein sequence ID" value="ACU08182"/>
        <property type="gene ID" value="FIC_01739"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01739"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_10"/>
    <dbReference type="OMA" id="PYDDFPE"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008866">
        <property type="term" value="F:fructuronate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="271" mass="28364" checksum="C3145C7FD19E289C" modified="2009-09-22" version="1">MKDLFSIEGKVAVITGATGVLGSSLAKSFLQAGAIVVALGRSQHKLDAKAAELSANGGEVFAVEANVMDVPSLEQASNKILEKYGKIDILLNIAGGNIPAATLSAEQSFFDLEMSAWDEVTDLNINGTVYPSYVFGKVMADQGSGSIVNISSMAAYSAITRVAGYSAAKSAITNFTQWLATDIALKFGDKIRVNAIAPGFFIGDQNRKILINEDGSLTERSQKVIAKTPMGRFGDAEELNGAVQFLCSEAASFITGALLPVDGGFSAYSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X192</accession>
    <name>C6X192_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01762"/>
    <dbReference type="EnsemblBacteria" id="ACU08205">
        <property type="protein sequence ID" value="ACU08205"/>
        <property type="gene ID" value="FIC_01762"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01762"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_1_10"/>
    <dbReference type="OMA" id="YRWEEST"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="142" mass="16309" checksum="127C6059F5B1DFA7" modified="2009-09-22" version="1">MKNGHLQKSRVTPINNLNNMNTENTKAQMRKGILEFCILSLIDKREMYVSDLIDALKKGKLDVVEGTLYPLLTRLKNGEFLSYRWEESTGGPPRKYYQITEKGKLFLAELINTWQDLTESVNQITKNNNPTDAPQNSFEPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A2</accession>
    <name>C6X1A2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806500.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01772"/>
    <dbReference type="EnsemblBacteria" id="ACU08215">
        <property type="protein sequence ID" value="ACU08215"/>
        <property type="gene ID" value="FIC_01772"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01772"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134999_0_0_10"/>
    <dbReference type="OMA" id="DKYETGR"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="146" mass="16184" checksum="2014660DEEC538BF" modified="2009-09-22" version="1">MDKTELVQLVKTKLADKASNLEKLIRQTQESNSETKSSMGDKYETSREMIQQEINNLQRQLNECLEQQNSVTKLITESCTEVKLGAVAETNLGFFYVATSVGVISLGSMKIHTVSTESPIAKAMNGKNKGETFTMNGALQTLKNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A6</accession>
    <name>C6X1A6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01776"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08219">
        <property type="protein sequence ID" value="ACU08219"/>
        <property type="gene ID" value="FIC_01776"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01776"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008843_0_0_10"/>
    <dbReference type="OMA" id="CILEQDA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="824" mass="93697" checksum="AD60B1224EC574A0" modified="2009-09-22" version="1">MTEFSHIVYEIVIWFFLLYACGVVLVYSWMGIYALGAVLRYKRENTFTDYSIIASNPNAPVFSLIAPAYNEGMTIVENVRSLLSLYYHNLEIIIVNDGSKDDSIQKLIEAYELESVNFFIQGNIPTAEVRGIYKSKNPAFRKLTVVDKANGGKADALNVGVNISGGDYLVCIDVDCILEQDAILKLAKPFLEQTDKKLIACGGVIRLANNCRIENGKVVEVNLPRTLLGRTQVLEYIRAFVLGRMAWSRASGLILISGAFGVFDRKIVLACGGYDKNTVGEDMELVVRMRQYMEERNEPYEVINIPDPLCWTEAPESKEILVKQRNRWMRGTMETLWKHRKMMFNPRYGKLGTVSLPYWFTFEFLGPLIEFAGYFIFVIFLLLGIINWSFFWILFALVISAGFLYSIYAILVDLVSRQVYTKRKDFMSLITTALLEPFYFHPIVVRAGVKGFVDYFKKSHSWGEMTRQGFSQETKNLPLAKRLLAMVTFALRSWGVAALVLILFFMIAVGAEWAWYGYSEDSLNTERIVGNLFLDNTLFLFKMLFGLGIIYLIVYLVNGRWARNLALVLFSGMVIFQFVLFIYFSESGSLLGADVQYYDREEMKQTLQASGMLNLKNIALGIILTAVAVVPFLFAGRSTLKSPAAGLIILGLGLVALFIPRQAFVLRDANEFEQNAAKSKWEYFFSSNISNIISQNPEITRLLGKPETFASHSEMLDKDYPFWKKEDTRDFLGPMFNKSERVPNLVLVVMEGFGNAYTTPRGYIGNFAPFLDSLAGKGLYWENALSSTGARSAHFQRLRDLYLLEITASWKWIKRLPISIFIMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B5</accession>
    <name>C6X1B5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806513.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01785"/>
    <dbReference type="EnsemblBacteria" id="ACU08228">
        <property type="protein sequence ID" value="ACU08228"/>
        <property type="gene ID" value="FIC_01785"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01785"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034925_1_1_10"/>
    <dbReference type="OMA" id="DSFDWQD"/>
    <dbReference type="OrthoDB" id="468923at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972207" evidence="1">
        <location>
            <begin position="22"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="406" mass="42326" checksum="284038680B99E446" modified="2009-09-22" version="1">MKKNILNLLSLAALFAVTSCTVEIREEADINGGGTGTGGTTGAILSGTGTLTGTLKQNTVVKKGTYTLEGIVKVPEGISLTIEPGATFTAKTSVGSSLVVLQGGKIYAEGTASEPIVFTSDNKKPGDWGGVTLYGNAPIKAINGAAKALSEDGNNVYYGGDNPNDNSGSLKYVRVEYGGKKIGDGTSETNSLTFYSVGAGTVLENIVAYMGTDDGYEFFGGTVSGKNLVAYGNYDDSFDWQDAWSGQNNTNWFAYQTAIGNFGMEIEASGNADNTAPKVNGITLIRAAGTKPETAGSVEVSAIQFKKHGNGIFSNVFIDGYKDTDGKKAYAVLIQDAATENEQVNKGKISVSPVNHTGSDNLNIWGYAYTPNGGKTFTSDTAVKKVTLSSGNWATVNGVDLLSALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C7</accession>
    <name>C6X1C7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08240">
        <property type="protein sequence ID" value="ACU08240"/>
        <property type="gene ID" value="FIC_01797"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01797"/>
    <dbReference type="HOGENOM" id="CLU_3381970_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="33" mass="3933" checksum="9C88274DA1415FB0" modified="2009-09-22" version="1">MLAAICMVLLFYKITKQKKSGINIPDFIFYFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C9</accession>
    <name>C6X1C9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806527.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01799"/>
    <dbReference type="EnsemblBacteria" id="ACU08242">
        <property type="protein sequence ID" value="ACU08242"/>
        <property type="gene ID" value="FIC_01799"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01799"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079010_1_0_10"/>
    <dbReference type="OMA" id="AFMGAEF"/>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973470" description="acidPPc domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="109"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="235" mass="26482" checksum="D9A4CB1924E00D58" modified="2009-09-22" version="1">MIKNCFFLCFLCSFLSGFAQKSDSLRLYNQPFGFKTQKIYIPAVLMTAGILFDYDRVQAIDIENSGSETSDILGFGNHLDDYAQFAPVAAVYGFEWAGMQPRTDWQNRTAILIKGQVLNLGLVYALKKTLKKPRPDGTAFSFPSGHTANAFAGATMLSIEYGENHRWVPYVSYGFATGIGIMRMANDKHYISDVLFGAGLGIISMKIAYWTHQYRWNQTKSTVDPFVSIYRFHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E3</accession>
    <name>C6X1E3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806541.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01813"/>
    <dbReference type="EnsemblBacteria" id="ACU08256">
        <property type="protein sequence ID" value="ACU08256"/>
        <property type="gene ID" value="FIC_01813"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01813"/>
    <dbReference type="eggNOG" id="ENOG50342KY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2329588_0_0_10"/>
    <dbReference type="OrthoDB" id="1961871at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="98" mass="11697" checksum="BF37E65290B0965F" modified="2009-09-22" version="1">MKAKKKYKKQLINSLKEMASTEYVLLETMTNLMLLKEMKEQNISFKEGDTFSFEDNIFDYSEDKNVRRLAKLRKKMIKTMNKLVDKGNFKDKEIEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I7</accession>
    <name>C6X1I7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 inner membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806585.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01857"/>
    <dbReference type="EnsemblBacteria" id="ACU08300">
        <property type="protein sequence ID" value="ACU08300"/>
        <property type="gene ID" value="FIC_01857"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01857"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_1_0_10"/>
    <dbReference type="OMA" id="LFVIMDP"/>
    <dbReference type="OrthoDB" id="1323133at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="198" mass="21648" checksum="2685CD2999C24213" modified="2009-09-22" version="1">MFEYFSLKETLTATMVLFAVIDIVGSIPIIVSLKKRFGHIEAGKATLAAMFLMIAFLFIGNKILKFIGVDVNSFAIAGAIVIFIIALEMILGIEIHKNQEAKSASIVPIAFPLIAGAGTLTTTLSLKAEYHDINIICGIILNTLFVYLVLKSANWIERKLGEGTLQVLQKVFGIVLLAISIKLFTANFAQLFSSYVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K1</accession>
    <name>C6X1K1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnogalacturonides degradation protein RhiN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806599.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01871"/>
    <dbReference type="CAZy" id="GH105">
        <property type="family name" value="Glycoside Hydrolase Family 105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08314">
        <property type="protein sequence ID" value="ACU08314"/>
        <property type="gene ID" value="FIC_01871"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01871"/>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038720_1_0_10"/>
    <dbReference type="OMA" id="PLVWNRA"/>
    <dbReference type="OrthoDB" id="982403at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970538" evidence="1">
        <location>
            <begin position="21"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="400" mass="45273" checksum="C3FA66AA01D196B6" modified="2009-09-22" version="1">MISIKIKTLAVAIFGSLVLAGCKTASTANMEVPSNKKWSERMALTLMKKYPEAYMLDDKTAPKWDYVHGLVMMGFEELYQKTNNQQYYDYLKGYADATIDANGKIPSYKFENYNIDMVVAGHHLFDLYDKTKDARYLTAMKTLRSQLDAQPRTSEGGFWHKKIYPNQMWLDGLFMGSPYYARYNTTFENGDKLNDVALQFELVQKNMVDPKTGLLYHGWDESRAMPWADKTTGNSPNFWSRSLGWYAMALVDVLDYFPKDHPKRPQLISYLNSLAKAVTNYQDASGLWYQVTDQGNRGGNYLEASGSSMFAYAFAKGANKGYLPNEYKTVANKAFDGLVKNLITVSPEGYVTLTQVCAVAGLGGKPYRDGSFEYYVNERKKDNDPKGTGPFILAALQLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K4</accession>
    <name>C6X1K4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pectate lyase/Amb allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806602.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01874"/>
    <dbReference type="CAZy" id="PL1">
        <property type="family name" value="Polysaccharide Lyase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08317">
        <property type="protein sequence ID" value="ACU08317"/>
        <property type="gene ID" value="FIC_01874"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01874"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011039_0_0_10"/>
    <dbReference type="OMA" id="MLTSMQG"/>
    <dbReference type="OrthoDB" id="660314at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041253">
        <property type="entry name" value="CBM77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PTHR31683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18283">
        <property type="entry name" value="CBM77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973344" evidence="3">
        <location>
            <begin position="22"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Amb_all" evidence="4">
        <location>
            <begin position="197"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="830" mass="88888" checksum="BA827AF4828EBADF" modified="2009-09-22" version="1">MNRFLFILSWLLSITLINAQAANITQQSGSLESAYVKWDPVTGADSYNVYYSGAGITDRKIDTQLIRSYGTYFRADVLGLAAGSYTIKVVPVTEGVEGSPAVSNPIEVVAHDRNGFAHQGSRVPGAYNLDGTLKSNAVVIYITQNTKNTVTLNVTGATANPCVGLQTILDGFKKGKDSRPLAVRLIGNITDPSYLLSGDLVIENNNLATASMTLEGVGDDAYANGWGVRIKNASNVEVRNLGLMLTDASEGDNIGLQQGNDHIWVHNNDLFYGKSGGDADQAKGDGAMDVKKSTYVTLSYNHFWDSGKANLLGLSEGTAAGLYATYHHNWYDHSDSRHPRVRYYSAHVYNNYFDGNSKYGAGSTMGSSLFLEGNFFRNSKYPMLTSMQGSDIFSGPGTFSSENGGVIKAFNNTMSGQNRFVAYDAVNYPVEFDAYVATSRGEVLSSAIKAKKGGATYNNFDTDAAHYIKNLIVDEPEVAKAKVIQYAGRVDGGDMKWTFTSADDTSYDVNTGLRDMLINYNSSMVYVQGETPVVVSTQTLLIPENNDQTVPAGTPIQNMVFTWGGTANDVTVDGLPASGLTFTKNITAKTVTITGTPTADISFTVTTSGTAGTPVSGTGIVTIGEASTESTFIHNFTTDGKISSYYAISGNMNSTDGSNTYDGNILTKRLKIESATTINYTTAKKSTLTLVFDPTFAGKIKLNGTNYTVPAGAGGVITIPNVPAGATQILKGDTANLFYIKTVYDDVVLGTGVQNTRAELSVYPNPVTETVFIRTDENVRNVSIFSANGSLVKSADGNVKSIDVRGLTTGMYIVKIVTQSGTVTRKIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L3</accession>
    <name>C6X1L3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate hydrolase</fullName>
            <ecNumber evidence="4">4.2.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806611.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01883"/>
    <dbReference type="EnsemblBacteria" id="ACU08326">
        <property type="protein sequence ID" value="ACU08326"/>
        <property type="gene ID" value="FIC_01883"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01883"/>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029189_0_0_10"/>
    <dbReference type="OMA" id="MRHDKRE"/>
    <dbReference type="OrthoDB" id="889365at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008789">
        <property type="term" value="F:altronate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="537" mass="58066" checksum="A1569650914BDDBB" modified="2009-09-22" version="1">MENKLIKVNPNDNVLVALADIFAGDTVLFNGVEFTAQTNVKAKHKMAETDFMPGDSIIMYGVLVGKACLPVLRGEVITTENVKHQSEEVHGKTGTLPWIVPNVDRWKDRTFMGYHRADGQVGTKNVWLFFPLVFCENKNIEKLKEIFENELLPKKEVSYKLFLRSLIEEKSVEEVAEKQPDPNLLDNIEVKFINHQGGCGGIRQDSELLAKLLAGYVNNPNVAGATVLSLGCQNLQIDIFKNALQEMSPNSQKEVLIYEQQQIGTTDKMFQMVIKDSFEAIKRANKIPRQPAPLAKLSIGLECGGSDGFSGISANPALGVVSDIFAALGGKTILAEFPELCGVEQELMNRCVDSEKADKFLGLMKAFEKSVVDAGSGFDMNPSPGNIKDGLITDAMKSAGAAKKGGTAPIVDVLDYGEYISKPGLNLLNTPGNDAECTTGLVGAGATVVLFTTGLGNPMGNPIAPVVKIASNSAVVEKMSDIIDINAGTVITGEKTIQEVGEEIVEYIIDLASGNVETKADQLKQDVFIPWKRGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1N9</accession>
    <name>C6X1N9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01910"/>
    <dbReference type="EnsemblBacteria" id="ACU08352">
        <property type="protein sequence ID" value="ACU08352"/>
        <property type="gene ID" value="FIC_01910"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01910"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049865_0_2_10"/>
    <dbReference type="OMA" id="KINTHFT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="5">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="315" mass="34603" checksum="6F7B010A39C07C1C" modified="2009-09-22" version="1">MLRTQFRIAYPAFFKNMTFNNPQTLHTIAEIIGARMVGDGDFPVLGTNEIHRVKPGEIVFVNHPKYYDKALESAATVILIDKEVPCPPGKALLVSDDPFRDFNKINTHFTRIYNFSDVLHDIEVGEGTTIHPSAVLGNEIKIGKNCLIFPHVVIGDRTVIGDNVIIQSGTVLGGDAFYYRKLNGNFDRLISVGNVIIENNVEIGNNCTIDRGVTDSTVIGEGSVLDNQIQIGHDTIIGKKVLIASQTGIAGCCIIEDEVTIWGQVGMASGVRVETGTVLLAKCGVNRDLKKGTYFGPIAEEFKQYLRKEIKLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P9</accession>
    <name>C6X1P9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806647.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01920"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08362">
        <property type="protein sequence ID" value="ACU08362"/>
        <property type="gene ID" value="FIC_01920"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01920"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041132_2_0_10"/>
    <dbReference type="OMA" id="YYCGDDF"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="363" mass="41561" checksum="8DE2264FDA433166" modified="2009-09-22" version="1">METQVLKTHGNPDYDMIVFCHLRWDFVYQRPQHIISRLAKDYKILVVEEPTPTRLNGHSPLEVREITANIHVFRPPVQSIEKIGAFLKKHLKKQTFPVGWFYSPAFIPVLEHLEFDSVIYDCMDELSLFKGASAHLIDQEKQLLAAADIVYTGGKSLYESKKQKHHNVYCFPSSVDVAHFANENAESIEKPYDLRDIPQPIVGYYGVIDERIDLELLKKTAAKCASTSFVMIGPLCKIEEHDLPKADNIYYLGMKSYEELPAYLHYFDIAMMPFALNDSTKYISPTKTLEYMSAYKPIISTRIKDVVRDYSHCISLVTDENDFADAIEKAPTRDLSAYSEILEKTSWDATAEKMSSIIQKVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q0</accession>
    <name>C6X1Q0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
            <ecNumber evidence="5">5.4.99.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.9" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01921"/>
    <dbReference type="EnsemblBacteria" id="ACU08363">
        <property type="protein sequence ID" value="ACU08363"/>
        <property type="gene ID" value="FIC_01921"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01921"/>
    <dbReference type="eggNOG" id="COG0562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042118_0_0_10"/>
    <dbReference type="OMA" id="INVHKYG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="166"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="397" mass="46524" checksum="DB0ECC16F5E9BE22" modified="2009-09-22" version="1">MGCNRRKNEFNHTKSNCMTDIDILIVGAGISGATLAERYANIGKKVLIIEKRDHIAGNCFDYLDENGILTSKYGAHLFHTNEKDVWEYVNRFGEWYPWEHRVVARVDDKTVPIPVNITTVNTLFGTNISTEEEMKQWLDNNRVEFSPAKNGEEAVLNRVGPVLYEKMFKHYTVKQWDKYPAELHASVLERIPVRTNYDDRYFSDEFQALPKGGYTKIFEQMLDHPNITVLLNTDYFDVKDQYTGYEKLFYTGPVDRFFEFKKELDKLEYRSINFVTEHLDQEYFQETSVVNYPGNEVDFTRIVEYKHFGNQKSAKTSIVKEYTVDDGEPYYPVPNEKNQLIYEKYKEEADKLTDVYFVGRLANYKYFNMDQAFKNALDLFSSLETQNLKHHATGATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R3</accession>
    <name>C6X1R3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806661.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01934"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08376">
        <property type="protein sequence ID" value="ACU08376"/>
        <property type="gene ID" value="FIC_01934"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01934"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_21_1_10"/>
    <dbReference type="OMA" id="CAGNIEI"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="249" mass="28649" checksum="57B16576BB1D74F0" modified="2009-09-22" version="1">MKISIITVCYNSAKTIEETLKSVQNQTYKNIEYIVIDGASKDATTSIIEKYKDIITYFSSEPDKGLYDAMNKGIQQATGDYVGIINSDDVFYDNKTIEKVADYFAEHPHLDAITGNIVQHKNNRIIRKYSSANWSPEKLKRGFMPPHPAIFMKTSLYHKFGLYRLDYKISADYELIIRFFLKEKISYQYSGITTTSMAVGGASSSGYKSYKVITREVKKAFKQNNIGYSPLKVRFRFLWKIFGYINVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S7</accession>
    <name>C6X1S7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-keto.6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806675.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01948"/>
    <dbReference type="EnsemblBacteria" id="ACU08390">
        <property type="protein sequence ID" value="ACU08390"/>
        <property type="gene ID" value="FIC_01948"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01948"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_2_1_10"/>
    <dbReference type="OMA" id="RFWATQA"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="382" mass="42401" checksum="3F0F3E2810BDE80C" modified="2009-09-22" version="1">MKSSKIWLSSPHMGGNELKYIHDAFDTNWIAPLGPNVNGFEQDIQNFLGEDVYVAALSSGTAAIHLSLVLLDVKPGDYVICQSLTFSASANPIVYVGAKPIFVDSEKDTWNLCPNAVEDAIKFGISKGKKPKAIIAVSLYGMPYKADELQEISLRYGVPVIEDSAEALGSTYKGRKSGTFGDLAILSFNGNKIITTSGGGALVLKDQAFKKKAVFLSTQAKDDAPHYEHTKIGYNYRMSNVCAGIGRGQMEVLPLRVEKRREHHAFYKNLFKDQPQYTVHSEPSEDFYSNHWLSVITVKNEGGINNDWLRKKALKENIETRPIWKPMHMQPVFKNAEYFGGTFAEQCFRTGLCLPSGSNLTDEEMNRISDFFADVFSVSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1X0</accession>
    <name>C6X1X0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806718.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01991"/>
    <dbReference type="EnsemblBacteria" id="ACU08433">
        <property type="protein sequence ID" value="ACU08433"/>
        <property type="gene ID" value="FIC_01991"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01991"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_0_0_10"/>
    <dbReference type="OMA" id="TVGWCAQ"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="428" mass="48149" checksum="674419D80F3FA43D" modified="2009-09-22" version="1">MSDNKVVLNYDGNSYEYPIVDSTIGDRGIDISKLRDQTGLITLDLGYKNTGATLSDITYLDGDNGELYYRGYPIEQIAEKSNFTEVMYLLLHGELPTKDQFSGFEGGIKKYNFVADEMKKILDVFPRSAHPMGVLSSLTSALTAFNPKAVDVSSKEEMDEAAEMLLAKFSHLCAWTYRKKMGLSINHGDDSLNYVENFYKMCFRRPNQQFELDPVVVGALDKLLILHADHEQNCSTSTVRMVGSAHTGLFASVSAGISALWGPLHGGANQAVIEMLEMIEQDGGDVAKYVEKAKNKEDNFRLMGFGHRVYKNFDPRATIIKKAADDILNSLGIEDKALDIAMQLERVALEDEYFVSRKLYPNVDFYSGIIYRALGIPTEMFTVMFALGRLPGWISQWKEMRLHNDPIGRPRQVYQGAQKRDYLDLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y9</accession>
    <name>C6X1Y9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rplX</name>
        <name evidence="3" type="ordered locus">FIC_02010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806736.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02010"/>
    <dbReference type="EnsemblBacteria" id="ACU08452">
        <property type="protein sequence ID" value="ACU08452"/>
        <property type="gene ID" value="FIC_02010"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02010"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_0_10"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="108" mass="11531" checksum="96D313B96190F677" modified="2009-09-22" version="1">MTKLKIKRGDNVIITTGKKEIKGKTGEVIEVIRKEGKDARVIVAGLNIVKKHTKPSAGNPQGGIVEKEASIHISNVMLIDKDGKATKTGSKVDGDKKVRVAKSTGETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X216</accession>
    <name>C6X216_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806763.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02037"/>
    <dbReference type="EnsemblBacteria" id="ACU08479">
        <property type="protein sequence ID" value="ACU08479"/>
        <property type="gene ID" value="FIC_02037"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02037"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_10"/>
    <dbReference type="OMA" id="ILIFEAK"/>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="257" mass="28638" checksum="FD498163680C330C" modified="2009-09-22" version="1">MIESLQNEKIKHLTRLLTDNRFRKKSGTFAVEGKQENERARKFGYEPVEYFLCESIFDEDFPAGKISLVSEKVYEKVAYRGSSEGIIGIYNTKSFNLNAFAIKEDSSVIIIESVEKPGNLGAVLRSCEAFGIDALIITDPKVDFYNPNVIRSSVGCLFGMDIFQSENNALLDFLESNHFKIFTTRMSDDATDIFNQDFGGRSALVFGTEHSGLSDFWIGKGTNTLVPMTGSIDSLNLSNAVAVSGYEILRQKLQKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X240</accession>
    <name>C6X240_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806787.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02061"/>
    <dbReference type="EnsemblBacteria" id="ACU08503">
        <property type="protein sequence ID" value="ACU08503"/>
        <property type="gene ID" value="FIC_02061"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02061"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053649_0_0_10"/>
    <dbReference type="OMA" id="RGMEAMD"/>
    <dbReference type="OrthoDB" id="884913at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="383" mass="45286" checksum="04EB5964FBD1FE61" modified="2009-09-22" version="1">MKAVKVVTRDQVKEFLDFPAVLLGSDPNYIRPLDHEIEAVFDPKKSKYFRSGECERFLFKDSHNKTVGKVAVFINKKYKQKQPTGGFGFFDCIDDQKSADFIFNFCKTWLEEKGMQAMDGPINFGERDKFWGLLIEGFSEPLYGMNYNPPYYQRLFENYGFQIYFNQLCFGRKIHDAVAENFLAMHARISKNKSISAQRMKRGNLEKYAADFTEVYNRAWAQHGEGKEISKAQTLKMFQTLKPVINEHISWFVYENDRPIAVWMNIPDLNQWFKYLNGKLGIWQKIMFLLLKKFKKNKKMIGLVFGIVPEWQRKGIDGYMIWEGTQHFRRTTDFEDYEMQWIGDFNPKMIKIAESLETTVTRKLATYRYHFDAATVFEKHPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X248</accession>
    <name>C6X248_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type transporter ATP-binding and permease co mponent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_02074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02074"/>
    <dbReference type="EnsemblBacteria" id="ACU08511">
        <property type="protein sequence ID" value="ACU08511"/>
        <property type="gene ID" value="FIC_02074"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02074"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_7_10"/>
    <dbReference type="OMA" id="FNTLQMG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="345"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="378"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="590" mass="67646" checksum="ED26300E2B536570" modified="2009-09-22" version="1">MRRIFKQNMKKQSTWDIIKRLFRIGMKFRSWFIITLIISVLLSVISTYRPYLTMQIVDSDIIKLRDEGLMMKHIYILVALVFGETILNFFLVYFSNFISQNVIRDIRERLYHKLIYFRTSFFDKTAVGQLVTRAVGDVETIATVYTDGFLMVFGDILRIVFVLIMMFQVDVHLSYISLAILPLMVVITRFFQKRLRKAFGDERTWTANQNSFVQERLSGMSLIQVFNRQKAEFDKFDSINITLKSALLRTVYIFSLFFPVVELISSLFIGFILFYGGYITISAGVVIAFIQYISMLIRPLRQIADRFNNIQRGIVGAERVLGVMDEDFALPNEGKVSKDKFDGKIEFKDVYFSYDENQNVLQGISFKVNPGETAAIVGATGAGKSTIISLITRLYDINSGKILLDDVDLKEYELYNLRSHIGVVLQDVFLFHGTIFENLSFGDESVTLEKIKTVAADIGVDDFIESLPGGYEYVVRERGSSISLGQRQLLSFLRAYLSDPKILILDEATSSIDHESEKLIQRATDKITKNRTSIIIAHRLSTIEKADKIIVMEHGKIVEEGKHLELLSKNGYYSTLYRSQLKHEVEESAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X253</accession>
    <name>C6X253_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_02079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806800.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02079"/>
    <dbReference type="EnsemblBacteria" id="ACU08516">
        <property type="protein sequence ID" value="ACU08516"/>
        <property type="gene ID" value="FIC_02079"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02079"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_1_0_10"/>
    <dbReference type="OMA" id="CGACRQS"/>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="159" mass="17685" checksum="784731C91326AA7E" modified="2009-09-22" version="1">MEREIKITFEAIPNYEALDQTEKKLFDAASKIRDKAYAAYSHFHVGCAILLENGEIITGSNQENAAYPSGLCAERTTIFWTAANFPDVKIKKLFVIGAPKDAVSSTPIPPCGACRQSILEYEAKQKDGIEIYFASLDGEIFKTNSIRDLLPFSFDSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X281</accession>
    <name>C6X281_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrous-oxide reductase</fullName>
            <ecNumber evidence="1">1.7.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806828.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02107"/>
    <dbReference type="EnsemblBacteria" id="ACU08544">
        <property type="protein sequence ID" value="ACU08544"/>
        <property type="gene ID" value="FIC_02107"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02107"/>
    <dbReference type="eggNOG" id="COG4263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016420_0_0_10"/>
    <dbReference type="OMA" id="HQEMQGY"/>
    <dbReference type="OrthoDB" id="74414at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050304">
        <property type="term" value="F:nitrous-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04223">
        <property type="entry name" value="N2OR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034205">
        <property type="entry name" value="N2OR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026468">
        <property type="entry name" value="Nitrous_oxide_Rdtase_Sec-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041114">
        <property type="entry name" value="Nos_propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18764">
        <property type="entry name" value="nos_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04246">
        <property type="entry name" value="nitrous_NosZ_Gp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="666" mass="73298" checksum="7EF28DC871E22286" modified="2009-09-22" version="1">MKSLKLFGLATVVAISAVTGCKPKGTETAVSGDAAQKVYVAPGKYDEFYNFVSGGFNGQVNVYGLPSGRLLKVLPVFSVNPENGYGYSEETKPMLQTSHGFIPWDDQHHLSLSQTKAEVDGRWLFANANNTPRVARIDLKTFKTVEILEIPNSAGNHSSPFLTENTEFVVAGTRFAVPMDDQNGDVPISSFKENFKGVLSFIGIDQQTGGMDLTFQIEAPGINFDLSHAGKGKSGDWFFFSCYNSEKANTLLEVNASQNDKDFIMAVNWKKAAALAKAGKGRKVVTEYAHNKWDEETHSATSTMKKEVVVLSVQDMKDAMYMIPCPKSPHGVDIDPTGEYIVGSGKLAALIPVFSFDKIQKAIADKAFAGEYDGVQVIKYEAALYGEVQKPGLGPLHTEFDGKGNAYTSMFVSSEVVKWNIKDLKVLDRTPTFYSVGHLMIPGGDTSKPFGKYMVAYNKITKDRYLPTGPELAQSAQLYDISGDKIQLLLDFPTFGEPHYAQALPGEMISKNQVKFFKIADNKHPYATKGEAESKVVREGNKVHVYMTSIRSHFAPDNIEGVRVGDEVYFHVTNLEQDWDVPHGFAILGNENAELLIMPGETCTLKWVPKKAGMFPMYCTDFCSALHQEMQGYVRVSPAGSNTPLIYSLNNKKDNAQSPVKPGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X291</accession>
    <name>C6X291_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806838.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02117"/>
    <dbReference type="EnsemblBacteria" id="ACU08554">
        <property type="protein sequence ID" value="ACU08554"/>
        <property type="gene ID" value="FIC_02117"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02117"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_5_10"/>
    <dbReference type="OMA" id="SYELQWR"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973617" evidence="5">
        <location>
            <begin position="21"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="41"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="216"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="635" mass="71250" checksum="E061570D85B86328" modified="2009-09-22" version="1">MKKKLFFVGALLVVSSDIFAQQETQIEEVTIASKTKQQLYKTGKNVQLISAQDLEKHRGQSLSDVLNQTAGFHIVGDFNNSQEPKALKIRGGKSSNVLILLDGIPLKDVTGNDYNVSDLRLMSLENVESIEILNGASSVLYGSNATVSVINIKTNRSATKKVEGLLGARAGSFSTYAQNALVKGKTDQFSYQLSATNEKSEGISSATGEDFEKDGFEKQTVNARIGFEAEQFSINVNGGWNHHLFDYDGGAFSDAEHRSDDEQHFIGGNANFRYSNGEISLNTRYSANNRLGQSLLNSNYKDQFSYAGRNFFSEIFNTYRFSENISFTAGVQFENQKMGAESLPWGANDLVEDLSLNDTKLHNVDVFANLNLKYNILNLDAGTRMTDHSKFGSHWVYSLNPYVLKEIGNLYFKAGYSLSTAFIAPTLYQTYGSLPYVLPNFELQPETNLSHEIDLSLGKKDQSLLFTASFFHRHEKDAFAYEIADAATYAGIFRNVAENKSKGFELGFNYRLNDFARLGANFSFVEKEKQETMLRQPKQRVNSYVEILPFRTTRVNLSHQFVSKRTDSYYDEVTFGVKSLELESFNIFNLNINQKIGANIESYLNVGNLLNESYVDVIGFNTLPRNFSVGVNYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X298</accession>
    <name>C6X298_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806845.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02124"/>
    <dbReference type="EnsemblBacteria" id="ACU08561">
        <property type="protein sequence ID" value="ACU08561"/>
        <property type="gene ID" value="FIC_02124"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02124"/>
    <dbReference type="eggNOG" id="ENOG502Z7T3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052630_0_0_10"/>
    <dbReference type="OMA" id="WGFNYYR"/>
    <dbReference type="OrthoDB" id="1381855at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024294">
        <property type="entry name" value="DUF3810"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12725">
        <property type="entry name" value="DUF3810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="354" mass="40740" checksum="892F8382E53CEBEA" modified="2009-09-22" version="1">MATKIKIFNSKKFWAGILLAQIVVFYICSKIDFIVEATAHFFEVQKATHQKFTAGVPFSLGDVFYILLIVLLIIFLYKIFKKSSRNAALLSALIFINVLHFVYQLYWGMLYYQKPILETLSREEITVQETQSLALKYLELCKKSRAQVREDQNGVFKISDLSEVKTQILQNQHQLPTFAVPRKGTNTDVFKPSLFRGLMSYSGILGYYNPFTAEAQYNAELPATYLPFTLAHESAHQLGYAREQEANFIGYLIGKNSGNADLRYSTQYAVLKSLLNALSEKTPGFVENAIRLYSPAMQRDREAEKLFVQQHQGVLDVFFGYTNDLFLKSNRQEGSVTYSYFVDLLVRFERQEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A4</accession>
    <name>C6X2A4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="11" type="ordered locus">FIC_02131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02131"/>
    <dbReference type="EnsemblBacteria" id="ACU08567">
        <property type="protein sequence ID" value="ACU08567"/>
        <property type="gene ID" value="FIC_02131"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02131"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_0_10"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="18908" checksum="D4B3368376052A7A" modified="2009-09-22" version="1">MSDYFFILTLNTRNMASYVTKEGLDKMKAELEQLETIERPKITQQIAEARDKGDLSENAEYDAAKEAQGMLEMKISKIKDIVINAKVIDETQLDTSKVSILTTVRLKNNDTKAEQKFTLVPDNESDLKSGRISVNTPIAKGLLGKTVGEKADIVLPNGNKLSFEVLEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D6</accession>
    <name>C6X2D6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806883.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02163"/>
    <dbReference type="EnsemblBacteria" id="ACU08599">
        <property type="protein sequence ID" value="ACU08599"/>
        <property type="gene ID" value="FIC_02163"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02163"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011210_0_0_10"/>
    <dbReference type="OMA" id="KYHIKLV"/>
    <dbReference type="OrthoDB" id="1623805at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973623" evidence="1">
        <location>
            <begin position="24"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="775" mass="84299" checksum="D8FCE1AA3F50B73A" modified="2009-09-22" version="1">MSRAKTSSSFTLLFILFHIFANAQQYISVDTSTYTAEQLVRDVFIGTSNAGCITVSNVSTSGWQTAGGSEASYGYFEKGTLPFDISKGIILSTGAVRNAPGPNNVLLDDQDDQWPGDPDLATALQEPVWNYLNSTSIEFDFVANNTSGISFEYLFLSEEYRRTNCTYSDGFAFLLKETGSSDAYTNIALVPGTLDPVTSLSINTAPNCPRNTGYFGSFNGSNSPTAFDGQTKVLTASTDIVPGVKYHIKLVIADHLAGSDRTGRYDSAVFLKAGSFIGKKDLGPDLLIATNNPVCEGSSRILDATTPGATSYQWFKNGAPIAGATNATLTVPGVVLSNGSYEVEVNISGCILTGSIKIEIQEKPAINFGTFTLCDDNLSGSIPVDFSTLDAQIISNFNATYVAKYYLEKTDSQAGTPGTELPNGWLLIADTPIYVRVESAFGCNPEFGEIMLKFGNKTPLLANTVSDDVCDNDLNGNITVNLQNYQLQFTNSAQVNVTFYNSVQDAQNNLNPISENQTLTASKTFGVRFESSAQCPNVGTLVINLKFPKKSTVLADVIICNNALTTLDAGSEFDSYLWSTGETTSQISDVAVGGYWVELGFNGCIYRQTVKITPSVLPQINNIEVAGNTATVYVTGGVAPYEYSLDGISFQISNVFKNIPRGLHKAYVRDAQKCVTLEKEFLIINLINVITPNGDGENDFMDYSDLRIKENVQLKIFDRIGTTVYQSANQTFVWDGKLSGRPLPTGTYWYHISWIEPDTKLPVNYHGWVLLKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E0</accession>
    <name>C6X2E0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thrombospondin type 3 repeat:OmpA/MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806887.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02167"/>
    <dbReference type="EnsemblBacteria" id="ACU08603">
        <property type="protein sequence ID" value="ACU08603"/>
        <property type="gene ID" value="FIC_02167"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02167"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043946_0_0_10"/>
    <dbReference type="OMA" id="DKQISHT"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972243" evidence="1">
        <location>
            <begin position="18"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="370" mass="40185" checksum="F29987C3597928D8" modified="2009-09-22" version="1">MKLGLLFALILPVASFAQDAPVVTGSTDYPNTYSSGSADVSNFDNSARRFNDWSISVGGGTALMLKSDLTSFYGDEINWGWNAYASIDKQISHTFGLSLQYQMGESRQRGQLPGAAGVAAGVAEATTEYQQISVLGDINFSNLLRRTDNHSPFRWALHGYAGLGAQGYETLLLDNNLSRYAPNTFPIAVDQKLSFASFFFQTGLGLKYNASKLIDVELRTMYIMSGDEEFDGGGDLRDTGRPSINYNLINPGYSDDMLTVNLGLSFKLGKHDSHLAWHDPLQEVYYRTELLENAPDDLVVCVKGDNDNDAVCDDWDRQLDTPTGARVDGAGVALDMDLDGVIDLYDQCVTVPGAADNNGCPAGTRSSSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G8</accession>
    <name>C6X2G8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02196"/>
    <dbReference type="EnsemblBacteria" id="ACU08631">
        <property type="protein sequence ID" value="ACU08631"/>
        <property type="gene ID" value="FIC_02196"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02196"/>
    <dbReference type="eggNOG" id="ENOG502Z9EE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318514_0_0_10"/>
    <dbReference type="OrthoDB" id="402522at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="932" mass="105421" checksum="892A178D5C3EA661" modified="2009-09-22" version="1">MRLLRTIFSFFFIFGTIAAYSQSGKVSIETDSAMVAANGEMRSLMVRIENNTAISQDLHLVSKADDGIRILNAKAVVKINPGEKLFVPFKIFIEKRQPAGSSVISLQLQDASEKTVATWETLLTVEPKRLLRISANEPQVLIYRVGDSLKISTQVTNGGNQTEQAEIFATFPQYLGSETVLKKKVTLQPFTSQKVEFSRIVDRDLLRMEIFTVNVAGTNSNKEFFGNAMVMVQNALGNRRYIDPQLHNTYRRASENHISWTTSNPFEQYSASHNIDLRSEVSVGDTNAIFNINGTYWPTLDTKMLFQNTWLKLEHKQFGLQVGNLNSSDLEINLNGRGAQLSYTPDAAGKTMITTGAVEKSYNIFDPIRLNNFPRGYSAFAKSVHSLGENEKLDGEVVLDTDPFQKSFILKSGYEFNNRKDTSYDIDAGYGYTRSSRDAGDTKSSVSLGFNYRKSWDKYAFSSSNYYSSGYYPGIKRGSTVSEHRISRTFEKFSLYGGYSLNIYNPKNIEPLYQFNSLTERHRAEAGSNFTLGKRISVNMVSQLSGEESDVFLGDAYAQVPVKFNSATLSAALNYSTTDNRNRFTLAHAQGFSQYEGRIEAQHIYSFQANWHRGNFMLSANYQHGNFLLYEGSRNGVLTSDSEKFSAIANYRLSLLNNRFNLNLTTLANLDSQTGNSVSLSSHFDYRLLRTTKIFGSYNYNRYSRGGFDTGNSYYQFGISQDLPRIGDESVKYRNGMIKVFTFYDLNNNNLYDAETDKPARGAKVKINNTIFIADEDGNIRYRKVPYGEYIVKPAETDWYGDTTKADLQQKEILIILALEKTGVMRGTVEYEKTSRIQYEVQERLAGIPVLFRNSLGKTFTFYTNDQGAYNAYLPLGSYEVFLDSQVLQRNVYVEHNLQAAVAEESGVTVIDKFLLKVREKKVEIKRFGIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J7</accession>
    <name>C6X2J7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806944.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02225"/>
    <dbReference type="EnsemblBacteria" id="ACU08660">
        <property type="protein sequence ID" value="ACU08660"/>
        <property type="gene ID" value="FIC_02225"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02225"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_4_10"/>
    <dbReference type="OMA" id="DEMYRFA"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="20151" checksum="E8A80AA2F69BA12F" modified="2009-09-22" version="1">MTHAIFKDTVFCLKDEMYRFAKRFVMSSDEAEDVVQDLMMKFWQKKEELATFGNLKSYAMKSVKNECLNRLKHHDVKMGFADFQLHRSELYQIETNNLKDQILGFIRQLPEKQKAVIHLKDVEEYDISEIAEMMDMEENAVRVNLMRARQKIKEQITQLMNYENRQISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P9</accession>
    <name>C6X2P9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02279"/>
    <dbReference type="EnsemblBacteria" id="ACU08712">
        <property type="protein sequence ID" value="ACU08712"/>
        <property type="gene ID" value="FIC_02279"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02279"/>
    <dbReference type="HOGENOM" id="CLU_3023719_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="56" mass="6108" checksum="7D731C3086C97B08" modified="2009-09-22" version="1">MFGIILAVCIMAFGIFLKTTKNEGFANSKKLSWLLIATGAITLIGKLVIMYQKGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R3</accession>
    <name>C6X2R3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807010.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02293"/>
    <dbReference type="EnsemblBacteria" id="ACU08726">
        <property type="protein sequence ID" value="ACU08726"/>
        <property type="gene ID" value="FIC_02293"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02293"/>
    <dbReference type="eggNOG" id="ENOG5033384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674493_0_0_10"/>
    <dbReference type="OMA" id="ANKSSAC"/>
    <dbReference type="OrthoDB" id="1751328at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="157" mass="18621" checksum="D4368A40A488B127" modified="2009-09-22" version="1">MKTQKILLDIEDAEDDIQLGLVRLVKEIPHHELFYHINSLNTFQFTRISDFVLRGTYYDHYFPRFESFHYDSKICLHFIANKSSACVQKKVSVELFSGEDESRFLLSNSPDVDYVIKTSEPFDEFSLILHPENLMFKIQDFTLSPTEELYQTILYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R9</accession>
    <name>C6X2R9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02299"/>
    <dbReference type="EnsemblBacteria" id="ACU08732">
        <property type="protein sequence ID" value="ACU08732"/>
        <property type="gene ID" value="FIC_02299"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02299"/>
    <dbReference type="eggNOG" id="COG3127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091995_0_0_10"/>
    <dbReference type="OMA" id="YGLYFWA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="229" mass="25966" checksum="4F5D72E4125333D2" modified="2009-09-22" version="1">MLLQKERKCKTCRKMISFVIQSVIMESKNYHEDLTHIRSMMERSSRFISLSGISGVFAGLVAILGAVYIYFVLRREGIDYFAGNSNVFSKDLVCEMLVIGGVILVLALLSGYIFTAKRSREKNLKIWDQTTKRLLFNFAVPLVTGGLFCLGLLYHGMFVFIAPATLIFYGLALVNASKYTFNDIQNLGYCQIVLGLVSFFFLGWGLVFWTLGFGVLHIVYGLVMHRKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T4</accession>
    <name>C6X2T4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative outer membrane protein probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02314"/>
    <dbReference type="EnsemblBacteria" id="ACU08747">
        <property type="protein sequence ID" value="ACU08747"/>
        <property type="gene ID" value="FIC_02314"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02314"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OMA" id="FNIANDH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="371"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="999" mass="110605" checksum="19FF1D0D593A9396" modified="2009-09-22" version="1">MPIKILNNVNMNVKLRVLSIGVLFFAGQSLMAQKRDTATKTKEIEEVVLVGGVRLDPAQKVGSYSVVGKANFESTPFSTVDEVLNGRVAGLNFSSASGDPGSSNMVIVRGVSSLIGTPNPLYVIDGIVIGKGADNAQMMESWNPLAVIDPNSIESVTVLKDASSTALYGSRGANGVIIVKTKKGKFNQKTRFEFSTETGVQGRAHDKLQLMNGDEYIKYGGILMWNSQDLLGQTFTTLEQATQYYLDTYIPDTEPIKYTRQYTDWQKVVNRSSSIVNTYNFGASGGGENTSFRIGGSYYQNEPLVKSSSFDRISVNAAVDHKASDKLRFGLNTNYSNVKRNTYMGGRASANPVTNSIMLSPLRSVYNADGTFNQEAWTEGPDMTAGFNPASILANAYQLSGINTFLASINMDYQFMKNVSFNSLFGTQYQTMRELQSIDKGHPIYTAQTDSDNFGMLQDARTSIWDWNWSNSIGYRNTFNARHNLEVLGGMEYQNHRYNNLTNYSFFMTDVRPYFQFAQEGSVLSYSDDYDWTQIGYFGRLNYILDGKYTFTGQLRRDGNSTLGTEKWGNFWSLGGSWNVFNENFLPSAFSSFTLGASYGVLGNIPYADQWGLQYNAYALVGYNASQGGWGGNGGYGGISNPGNPSLIWEEAKHLDINVDMGLFNDRLKLIGAFYHKVTEKAIDVSFPATETGGPTSFYDNIATIDNKGVELTIEATPIQTENFRWTINGNGAYSKTMLNRFNLELRQNGSEEPSGADNAFAALAPGHIFGEYYSVLWAGIAGADDPTRGIKAGDALFYTNGDKTDVTNKREDASPAWMGKSAFPVYNVGLTNELKYKNISLSFMLSGQFDFYVQNGVHSYTIHDGAFPGRNQINDALYDSWTDAPGAENFNASNPKAIVGNPSTSRLESSRFINKGDHIRLKEMRLAYTFGNQFKESTGLNNLTIYVRGTNLLTYVFDKDLDYDPESNSNAWSWLGKGRYWYASPVLKTMSMGIQVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X328</accession>
    <name>C6X328_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807125.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02408"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08841">
        <property type="protein sequence ID" value="ACU08841"/>
        <property type="gene ID" value="FIC_02408"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02408"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_0_10"/>
    <dbReference type="OMA" id="THWFWDT"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="246" mass="28036" checksum="5D306942267D82C1" modified="2009-09-22" version="1">MKNAIIIPCYNEAARLPTAGYINFLESEKSCTLVFVNDGSTDDTIGVLNALKTDFPANVLVIDLRFNLGKAGAVRAGMNECLAGGISYDRLGYLDADLATSLEEWLAISEKVTDDVIFAFGARISKIDNFISRKKYRHYAGRVIATFISEALKFPVYDTQCGCKVFRKDVAEAVFKDAFISRWLFDVEIFFRLRNTFGAAEMRRICREVPLERWHDVAESKVKFTYFFRLWIDLLLIAKKYRNAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X340</accession>
    <name>C6X340_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system, transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807137.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02420"/>
    <dbReference type="EnsemblBacteria" id="ACU08853">
        <property type="protein sequence ID" value="ACU08853"/>
        <property type="gene ID" value="FIC_02420"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02420"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_10"/>
    <dbReference type="OMA" id="NIHGEGF"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="228" mass="26669" checksum="C08E68A3B0536BEA" modified="2009-09-22" version="1">MNNRILLVEDDQSFGAVLKDYLSINNFEVTLATDGEQGLKEFTENEFDICIFDVMMPKKDGFSLAEDVKRIDKNTPIIFLTARNMREDILKGYQLGADDYITKPFDTELLLYKIKAILQRSSVSEDEEQEQFKISNIFFDSMLRQLKVGDNEYKLSPKENELLKLLCMHRNDFMPRDLALRKIWKKENYFTARSMDVYIAKLRKLLKEDSGLEIINVHGEGFRLLVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X345</accession>
    <name>C6X345_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase HemD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02425"/>
    <dbReference type="EnsemblBacteria" id="ACU08858">
        <property type="protein sequence ID" value="ACU08858"/>
        <property type="gene ID" value="FIC_02425"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02425"/>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076006_0_0_10"/>
    <dbReference type="OMA" id="KYVVYRK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="248" mass="28346" checksum="28D128B0D54A436F" modified="2009-09-22" version="1">MMMKIKSILVSQPAPNESSPYLEMAKKEKIRIDFRPFIHVEGVDAKELRTQKIDLSQFTGIIFTSKNAIDHYFRLAEEMRFAVPDSMRYICQSEAIANYLQKHIVYRKRKISFGERNFADLLPLFKKFPTEKYLIPAGETLSADTVKVLDSSSIDWTRATMYRTVSSDLSDIKLDEYDMLVFFSPQGIRSLGTNFKDFVQNDTKIAVFGTTTEMAAKEAGLVVNVMAPSKESPSMTMAIEKYIRSINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A1</accession>
    <name>C6X3A1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl endopeptidase</fullName>
            <ecNumber evidence="5">3.4.21.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.26" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807198.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02481"/>
    <dbReference type="EnsemblBacteria" id="ACU08914">
        <property type="protein sequence ID" value="ACU08914"/>
        <property type="gene ID" value="FIC_02481"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02481"/>
    <dbReference type="eggNOG" id="COG1505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_1_1_10"/>
    <dbReference type="OMA" id="ACMTQRP"/>
    <dbReference type="OrthoDB" id="315644at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="485"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="704" mass="79077" checksum="A890F019E3BC0C99" modified="2009-09-22" version="1">MKTHLIILTGALFAASCSPQKMTQNQLLYPETKKIAHTDEYFGTQVQDPYRWLEDDRAEDTKDWVNRQVTFTNNYLSQIPFREEIRSQLKDIWNYEKIGAPFKEGDFTYFYKNNGLQAQSVLYRTDKNGKTEVFLDPNKFSEKGTTSLAGISFNKKGNLVAYSISEGGSDWNKIIIMNALTKEIIDETIADVKFSGASWSGDDGFYYSSYDKPKGSELSAQTDTHKVYFHKLGTKQSADRLVIGGENFKRRYMGVDVSDDQRFEILNASEATNGNELYIKDLKNKTDFIPVQKGYTFNTDFVDSKGDIIYALTDKDAPNKRLVKLNINKPDVWIDVIPESENVLTVSTGGGYIFAKYMKDAVTSVRQLDYDGKLIRTIELPGVGTASGFSGKENEKELYFSYTNYITPGTIYKFNADTGKSEIYQKPNVKFNPENYVSEQVFYTSKDGTRIPMMINYKKGLKLDGKNPTILYSYGGFNISLQPGFSVVNAIWMENGGIYAVPNIRGGGEYGKKWHDAGTKLQKKNVFEDFIAAGEYLQNKGYTSKEYMALSGRSNGGLLVGAVMTMRPDLAKVAFPGVGVLDMLRYNKFTAGAGWSYDYGTAEDNREMFDYLKSYSPVHNVKKGVCYPSTMIITSDHDDRVVPAHSFKFGAELQEKQSCSNPALVRIEVNAGHGAGRSTDQVIGENADLLSFALYEMGFKTLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B9</accession>
    <name>C6X3B9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807216.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02499"/>
    <dbReference type="EnsemblBacteria" id="ACU08932">
        <property type="protein sequence ID" value="ACU08932"/>
        <property type="gene ID" value="FIC_02499"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02499"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102952_1_0_10"/>
    <dbReference type="OMA" id="TFRRYNY"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="217" mass="25048" checksum="921AAD39DE27712B" modified="2009-09-22" version="1">MFIKDYISKDYPAFNTGDSIEEANEFAKEFGYSHIFIKKKGIYQGAISQSFLEESPEGNLSTLAIHYEKFAITDDGNLLDSIKLFHTFNSNVVPVITKAEKYVGYLSCDDIFNEFSKYPLFSENGAVMIVQTSGRHYSMTEVCKIVEQNNGKIYGCFINLIGDDFIQITLKFNAENTSSIDETFERYGYSVVHKYYDDEKEDLLKDRFGFFQKYLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E7</accession>
    <name>C6X3E7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_02530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807244.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02530"/>
    <dbReference type="EnsemblBacteria" id="ACU08960">
        <property type="protein sequence ID" value="ACU08960"/>
        <property type="gene ID" value="FIC_02530"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02530"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_3_2_10"/>
    <dbReference type="OMA" id="PLGYDWK"/>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="10">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="679" mass="76536" checksum="33BA050AA8756B42" modified="2009-09-22" version="1">MMQKNSVNKQILLVGNPNVGKSTVFNLLCNKQQKTGNYAGVTVASHSGTYDFCGEVVEVIDLPGSYSIYPGSEDEAIFSKFLIDEQHNYAGVVYILEALSIKRGLLLFQQIQDLGIPVMVVVNQIDQAERRGININLEELSQELGVKVLQTNAKKNLGIEEIREAVFNNSFNVSETVSFEIPVEQKGLIFKILQESKEKNQYRIWTLLASETYFGKLESVKDQMNDDEVKCLVPKRLQTQETVRRYRNIDRIITKVLSKKPQFKELLTEKLDRILVHHIWGYLIFAAVLLMIFQSVFWLAEYPMIWISDAFFWLSTFVSTHLPAGPLNSLVANGIIPGIGGIAMFAPQIGILLYFLYLLEDSGYMARVIFLMDRFLKPFGLNGKSIVPLVSGTACAIPAIISTRNIENVKERLITILVTPFMTCSARLPVYSIIIALVIPDRHFAGISYKALTLMGMYFLGFFAALLTALLLKKIIKNKSKSFLVMDLPSYKLPLFGYDFKLVLGKVWEFITGAGKIIFFFSIIIWLFSYFGPKQQPDEMVATDVKLENSYLAQMGKAIEPAIAPLGYDWKMGVGVLTSFVAREVFVGTLSTLYSLDDEAPEDRIIDKMRNDTKPNGEKVFNFATGISILIFYAFAMQCASTLAVVYKETKSWKWTVAQLFGMSGLAYFASLIVYQMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G7</accession>
    <name>C6X3G7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Outer membrane protein P1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OmpP1/FadL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807264.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02550"/>
    <dbReference type="EnsemblBacteria" id="ACU08980">
        <property type="protein sequence ID" value="ACU08980"/>
        <property type="gene ID" value="FIC_02550"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02550"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035981_2_0_10"/>
    <dbReference type="OMA" id="NRYGFTY"/>
    <dbReference type="OrthoDB" id="620166at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005017">
        <property type="entry name" value="OMPP1/FadL/TodX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35093">
        <property type="entry name" value="PTHR35093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03349">
        <property type="entry name" value="Toluene_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972270" evidence="8">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="411" mass="44827" checksum="510BD03B4479AFF2" modified="2009-09-22" version="1">MKKLVVSTALLAGMLAQAGGFRVSLQGVKQLAMAHTSAHTEDASVAFFNPAGISFIPSKLSVAAGGFGINSEITYQNSSTLQSYSTDNPLGTPIYAAVAYKVLDNVSLGFSFATPFGSTVAWPEDWSGREIVQEIKLQAFYFQPMVSFKLAPWVSVGGSYIYAKGTVDWTKAVTQLGGTLNIKDEEASGQGFGLGFYFKPTEKLDVSIAYRSPVDMEAKNGVASFDISSALYPNVGLDANGQDNFTAVLPLVDEYTIGVTYRVTPKWQVSGDFNYSGWDRYGSLTLDFENAPAGNQPNDPTILVNPKNFKSTRTWRVGTQYMVTDNFAARLGYYYDESPYTDNNFIPETPSFNANVITGGIGYKWNGLGIDLSGGYNFQTPRTVNNEYLDFYGQAKAKAYYFGLGLSYNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M8</accession>
    <name>C6X3M8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782163.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00558"/>
    <dbReference type="EnsemblBacteria" id="ACU07016">
        <property type="protein sequence ID" value="ACU07016"/>
        <property type="gene ID" value="FIC_00558"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00558"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_10"/>
    <dbReference type="OMA" id="EYCTPIQ"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="233"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="450" mass="50848" checksum="03887D7664E01EA7" modified="2009-09-22" version="1">MEKITFADFELPEKILDVLADSNLFEPTPIQEKTIKPILSGRDVMGIAQTGTGKTLAYLLPVLKTWKYNKNGNPTVLILVPTRELVVQVSEIVKNLTQHLTARVLGIYGGVNIKTQKLLFNDGCDILVGTPGRIMDLAIDNAISLKEVQKLIVDEFDEMLNLGFKMQLTTIFTMMKEKRQNILFSATMTEAVDAVLYEYFADPVEISLAKSGTPLEKITQIGYKVENFHTKINLLEHLLKSDTDFSKVLIFCNNKRNADYLFTKIDEIFPDQFDVIHSNKSQNYRLNAMRSFENKEVRGLITTDIMARGLDISDITHVINFEIPEVPEQYIHRIGRTGRADKDGIAVSFVTKKEETSLLDIEILMDKAVLIKDFPAEVKINPLKIASEKDEIIMKNAHTVKLEEGGGAFHDKKDKNKKENWGGPTRRNPPKTKPANRAQAKAKSKAKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N7</accession>
    <name>C6X3N7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PorV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782172.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00567"/>
    <dbReference type="EnsemblBacteria" id="ACU07025">
        <property type="protein sequence ID" value="ACU07025"/>
        <property type="gene ID" value="FIC_00567"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00567"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058805_1_1_10"/>
    <dbReference type="OMA" id="RWRAGFN"/>
    <dbReference type="OrthoDB" id="686584at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045741">
        <property type="entry name" value="PorV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19572">
        <property type="entry name" value="PorV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PorV" evidence="1">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="373" mass="40657" checksum="11BFDC2937749B23" modified="2009-09-22" version="1">MTLTKKLFLGLGLGVGMMAYSQSKIVLTGAPFLRISPDARSGGMGDQGVATTTDAFSQFWNAAKYPFSTTTAAVGVNYTPYMGKLTNDVFLLYATYHQFLGEEERSTLSASIYYFNMGEVTLTELRNNLPQDMGISKPNEFSFDVAYGLKLSDTYSMAVTGRFIRSDLGGGLGSDNTLKPANTFAVDVSGYFQSERHTSINDFEGRARGGFSVQNLGPRLDYTGDEESRSYLPTMARLGAGYDLFIDDLNRVGVNFEASKLLVPGPDNTGAVPNVGVIEGIGKSFSNEKSMMFSGAVEYEYDNAFAVRGGYFHESEEQGARQFATVGVGLKYQSFGLDMSYLINTSKVNSALDNTLRFGLTWNIGEESSNSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P3</accession>
    <name>C6X3P3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782178.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00573"/>
    <dbReference type="EnsemblBacteria" id="ACU07031">
        <property type="protein sequence ID" value="ACU07031"/>
        <property type="gene ID" value="FIC_00573"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00573"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="232" mass="25638" checksum="9E647E4CA1BBC69A" modified="2009-09-22" version="1">MSLQIINLTKKFGAQTALNKINVEIGKSEIIGLLGPNGAGKSTLMKSIVGALKIDEGQIIFNGEDITLNDIAAKKNMGFLPENNPLYAEMYVKEYLQFVADIHQIPKTRIAEVIELVGITPEKTKKISQLSKGYRQRVGLAQAILHSPDLLILDEPTNGLDPNQIIEIRNVIREIGREKTVILSTHIMQEVEALCSRVILIHQGNILQDSPIEEFKGKYSSLEEAFAGYTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V1</accession>
    <name>C6X3V1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782235.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07089">
        <property type="protein sequence ID" value="ACU07089"/>
        <property type="gene ID" value="FIC_00634"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00634"/>
    <dbReference type="HOGENOM" id="CLU_2316136_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="99" mass="11837" checksum="16B052D51870FCE7" modified="2009-09-22" version="1">MKTDKKAKKICEADWLYDNFKPMKVQVFKINYDFFFDQDVGFNDEGETPELSENGEQYVLLNNEATFDFRDSSPWHTSTSLNEIKKYAEETLKQKLDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X416</accession>
    <name>C6X416_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulation protein FUR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00699"/>
    <dbReference type="EnsemblBacteria" id="ACU07154">
        <property type="protein sequence ID" value="ACU07154"/>
        <property type="gene ID" value="FIC_00699"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00699"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_3_0_10"/>
    <dbReference type="OMA" id="YETTFGR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="158" mass="18774" checksum="B76AAC56035AE852" modified="2009-09-22" version="1">MMEAKQKELNLVTIKEVLRQYLLKKGFRNTPERYTILEEIYMMDHHFNVDDLYLLMMQKKYHVSKATIYNTIEIFLDAGLIRKHQFGEKTLTSSSYEKSYFDKQHDHLVIYKEGSDKEIQEIIEFCDPRIQGIKESIESAFGVNIDSHSLYFYGTKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X419</accession>
    <name>C6X419_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782303.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00702"/>
    <dbReference type="EnsemblBacteria" id="ACU07157">
        <property type="protein sequence ID" value="ACU07157"/>
        <property type="gene ID" value="FIC_00702"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00702"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129812_0_0_10"/>
    <dbReference type="OMA" id="DNVNSRG"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045736">
        <property type="entry name" value="START_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19569">
        <property type="entry name" value="START_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="128" mass="14995" checksum="535C8EC8235A4942" modified="2009-09-22" version="1">MAKTKVQYEFPMHCQSEILYEYMASAEGLSEWFADEVLEKGDDFFFSWNSGPAEKATLIRYKPESFVRFRWEEDEGTKNFFEMTIAIDDITEDLSLNVTDFCDPGDEDENQLYWENLIENLKIKLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X441</accession>
    <name>C6X441_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polA</name>
        <name evidence="16" type="ordered locus">FIC_00724</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00724"/>
    <dbReference type="EnsemblBacteria" id="ACU07179">
        <property type="protein sequence ID" value="ACU07179"/>
        <property type="gene ID" value="FIC_00724"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00724"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_10"/>
    <dbReference type="OMA" id="NRPPMPD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="53EXOc" evidence="14">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="13">
        <location>
            <begin position="357"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="15">
        <location>
            <begin position="707"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU07179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="949" mass="108082" checksum="1C45A63A624DD1F1" modified="2009-09-22" version="1">MLRAKNIIFAFMSHNQDKRLFLIDAYAMIFRGYYALIRAPRMTSDGRDTSAIFGFTNSLIELIRRERPSHLAVVFDVGQASVRTVDFAEYKANRNETPEAIQLAIPYIHRILKAMHVPILGVEGYEADDVIGTIACKAEKEGYTTFMVTPDKDFAQLVTDKIKIYKPGLKGAEFTILGVDEVKEKYEIEDPKQVIDFLAMMGDSVDNIPGLDGVGEKTAKKFLKEYGNIENLLANTHEIKGKLREKVEASAERGILSKKLATIICDAPIEFHQEQYDLETPEWEKVKEVFDEIEFRRLYENLYRAFAPATELSQPVQQKSAASANPSSMQLDLFANFEELDHATRTKSTFEDNDVLYQYIDTPKAQKMLAWNLMSQKAVAFDTETTTLNEMDAELVGLSFSYRKGLAYYIPLSEDRSEAIQTLEIFREFFEKEDVSKVAHNLKFDYKILQQYGFSLKGLLFDTMIAHYLLNPDGKHVIDYLSEIYLNYKPVALESLIGKKGKNQLTFRSLTVEEQTNYAAEDADITWQLYEVFAPQLKKENLEDLFYKVEMPLLRVLAKMELEGVALDEKWLAQESIDLENDLRGLEAKIFELADVEFNVNSPRQLGEILFEKLKLDPKAKKTKTGQYATSEDVLQKLSAKHDIIKYILEYRTYQKLKSTYVDALPLQIDKDDNRVHTSFSQTTAATGRLASVNPNLQNIPIRTLRGQQIRGAFVAAEGKKIISADYSQIELRLIAEISNEENMILAFQNGEDIHVSTAARLFDIPLEEVTKTQRGQAKTVNFGIIYGQGAFALAEQTGLSRTEAKQMIESYFENYPRLKKYMGEQVQKAQELGYVETILNRKRHLKDINSANFVVKAHAERNAVNAPIQGSAADVIKLAMIKIDQKLSELNLKTKMLLQVHDELLFEAPQEEVEMVMKLIKTEMESAFETKVPLLVEVGVGDNWLEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X475</accession>
    <name>C6X475_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782359.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00758"/>
    <dbReference type="EnsemblBacteria" id="ACU07213">
        <property type="protein sequence ID" value="ACU07213"/>
        <property type="gene ID" value="FIC_00758"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00758"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_6_0_10"/>
    <dbReference type="OMA" id="IGNYMDK"/>
    <dbReference type="OrthoDB" id="2018797at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027367">
        <property type="entry name" value="Gly-zipper_YMGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13441">
        <property type="entry name" value="Gly-zipper_YMGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972289" evidence="4">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="103"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="230" mass="23958" checksum="0D8DE74DCB033DC5" modified="2009-09-22" version="1">MKLINKTNIAALFLSAGLLLTSCEAVQNANNQQKGTAIGTAAGAVIGGVLGNNLGKGRNAPAGAVLGGIVGGVAGNVIGRNMDKQAKEIKETLPGAEVERVGEGIRVTMKENMVNFGFDSSELTSAAKTNLDKLAQVLKNNMDTNINIYGHTDSKGTDAYNLSLSERRAAAVRSYLISQGVASSRMLTMGVGEKEPVASNDTDAGRAENRRVEFAITANEDMINEAASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X481</accession>
    <name>C6X481_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782365.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00764"/>
    <dbReference type="EnsemblBacteria" id="ACU07219">
        <property type="protein sequence ID" value="ACU07219"/>
        <property type="gene ID" value="FIC_00764"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00764"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_10"/>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="105" mass="11527" checksum="0CE0CE59535CE2CB" modified="2009-09-22" version="1">MAIEITDQSFQDTVLNSDKPVLVDFWAVWCGPCRMLGPIVEEISADFEGRAVVGKVDVDNNQQVSVDYGIRNIPTLLIFKNGQVVDKIVGVAPKETIAEKLSAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A4</accession>
    <name>C6X4A4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_00789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782388.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00789"/>
    <dbReference type="EnsemblBacteria" id="ACU07242">
        <property type="protein sequence ID" value="ACU07242"/>
        <property type="gene ID" value="FIC_00789"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00789"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_10"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="368"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="475" mass="54381" checksum="45122EB7862743E4" modified="2009-09-22" version="1">MNSYKNPLEERYSSEEMLYNFSPNNKFRNWRKLWIALAEIEKDLGLDISDEQIAELKANAENIDYEKAAEYEKKFRHDVMAHVHAYGDDAPLAKGIIHLGATSAFVGDNTDLIQMRDGLLLLRKQLVNVIKNLADFSLKYKDLPTLGFTHYQPAQLTTVGKRATLWLQSLILDFEELEFFIETLRFRGVKGTTGTAASFLELFDGDYSKVKHLDKELSRRFGFDKVFGVSGQTYDRKIDAKVMALLSNIAQSAHKFTNDLRLLQNLKEIEEPFEKNQIGSSAMAYKRNPMRSERIGSLAKFVMSLSSSSAMVAATQWFERTLDDSANKRLAIPQSFLAVDAILLIWNNIMNGIVVYENRIQKHIMDELPFMATEYIIMEEVKAGGDRQEIHETIRVHSIEASKKVKMEGKENDLIERIMNDSSLKLDKAKFMEILDMKNFIGFAPIQTEEFIQNEVQPILDKYSDLIGLEADLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F5</accession>
    <name>C6X4F5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782439.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00840"/>
    <dbReference type="EnsemblBacteria" id="ACU07293">
        <property type="protein sequence ID" value="ACU07293"/>
        <property type="gene ID" value="FIC_00840"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00840"/>
    <dbReference type="HOGENOM" id="CLU_1746928_0_0_10"/>
    <dbReference type="OrthoDB" id="2151065at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973452" evidence="2">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="16740" checksum="069A2BC3BD35081D" modified="2009-09-22" version="1">MIKILSLTFLLFTSLVFAQNQAQMASQEIAEANYKRQLSNAAFEKAVGEMRNSADKSAVEEANRLNDDFELNFAEKKKIEGKITAILQKIGALEEKLSRAKPGADTSALVQKIESLNLELEKQKKKSAQNEAELKTLQQSYRNLKNHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N6</accession>
    <name>C6X4N6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782520.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00923"/>
    <dbReference type="EnsemblBacteria" id="ACU07374">
        <property type="protein sequence ID" value="ACU07374"/>
        <property type="gene ID" value="FIC_00923"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00923"/>
    <dbReference type="eggNOG" id="ENOG5032SU5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2568825_0_0_10"/>
    <dbReference type="OMA" id="FVIHTEF"/>
    <dbReference type="OrthoDB" id="2009045at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="81" mass="9550" checksum="2231F5559591CF10" modified="2009-09-22" version="1">MKLPKFLLADNSEFPEDLFVVHTEYPRYILNVEEEEVEWLDDLQGDDEETMADEATKVVEAGFKWCDEELAKYDEEEDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R5</accession>
    <name>C6X4R5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SanA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00952"/>
    <dbReference type="EnsemblBacteria" id="ACU07403">
        <property type="protein sequence ID" value="ACU07403"/>
        <property type="gene ID" value="FIC_00952"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00952"/>
    <dbReference type="eggNOG" id="COG2949">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051474_0_2_10"/>
    <dbReference type="OMA" id="IDAWGVA"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="50"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="206" mass="23649" checksum="8B104A8BA97B8509" modified="2009-09-22" version="1">MKKLLDILRTFFTLVEIMVLLMVLANIWVYALTNGRTFTRISKIPPRETALVLGTSPRMKSGRSNPYFTARMDAAALLYHHGKIKRIIVSGEKSPGYDEPYAMKNYLIYQEGVPENIITEDPKGFKTQASISNCKKIYKQSNVIIVSQGFHNLRALFYARNNDMNALGFDAQDVLANRSYYRNQSREFLARVLAVVYYIFGIERKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T0</accession>
    <name>C6X4T0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mevalonate kinase</fullName>
            <ecNumber evidence="2">2.7.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.36" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00967"/>
    <dbReference type="EnsemblBacteria" id="ACU07418">
        <property type="protein sequence ID" value="ACU07418"/>
        <property type="gene ID" value="FIC_00967"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00967"/>
    <dbReference type="eggNOG" id="COG1577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902781_0_0_10"/>
    <dbReference type="OMA" id="GMYFDSS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="Galkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="328" mass="37336" checksum="68EC9268111BFB4B" modified="2009-09-22" version="1">MLRAKYFVTLQLTINALIQPMTNPLFYAKILLFGEYGIIEDSQGLTLPYSFYKGALKFSELESEFEKKSNSSLQKYSDYLHTLDLPAKFKLDISAFKQDLAKGLFFDSNIPQGYGVGSSGALVAAIFERYSVEKYVPDSITKDELKDLKKIFGQLESYFHGKSSGIDPLICYMNLPILIENRENVDRVSIPNGEAGKGAIFLIDSGMTGETGPMVQIFFEKMKTEGFRKTLKEEFIRYNNACIDAFLKKEMTPLFRNLKNLSVWAYEHFKPMIPESIYNAWKKGLDTNAYYLKLCGSGGGGYILGFTRDYEKAEKMLAGFEKEVIYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V2</accession>
    <name>C6X4V2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07440">
        <property type="protein sequence ID" value="ACU07440"/>
        <property type="gene ID" value="FIC_00989"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00989"/>
    <dbReference type="HOGENOM" id="CLU_3373897_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="34" mass="4162" checksum="EFB7F996EA220CDF" modified="2009-09-22" version="1">MMVLQALRFCFNFNVQNLNHFNPADKKCIFEEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X511</accession>
    <name>C6X511_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01049"/>
    <dbReference type="EnsemblBacteria" id="ACU07499">
        <property type="protein sequence ID" value="ACU07499"/>
        <property type="gene ID" value="FIC_01049"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01049"/>
    <dbReference type="eggNOG" id="ENOG5034346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786981_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="352" mass="42201" checksum="D9D8FFAF2478305C" modified="2009-09-22" version="1">MFWATLSAFRSRFRRGGELHSSRVAVKVFLENLFWISGTCVYLRVSDNHINHYSMIFQPEIFYSTYQKDFHKIKAIYLKKLLEFQDKEMERIFEENYNDFTKENIHRAIKSEIRQNLFHCIETFFDIFFALDPKETTNENHVNILKTLTQAKWRKNLKRIEKIAENPNELKFLDEFVETNHGNIKVAEYLFYYNLNLTKDVELKEKVTTSIEAIKYLILILSKEFSNRDEYNSYKHSIRLIPAVDSFSIFNPVANNVEVEFNLEDSLSYYVFETDNETQIEKIITKTFDVQRDINLTILCSNLISQLIYHRDHSYNKLKENISVSIFREEKITELNKRKVQIQKLIYTIKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X532</accession>
    <name>C6X532_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805805.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01070"/>
    <dbReference type="EnsemblBacteria" id="ACU07520">
        <property type="protein sequence ID" value="ACU07520"/>
        <property type="gene ID" value="FIC_01070"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01070"/>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103773_0_2_10"/>
    <dbReference type="OMA" id="YTAVSWN"/>
    <dbReference type="OrthoDB" id="1551899at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972315" evidence="1">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="173" mass="18061" checksum="4B31DB2EA48FD833" modified="2009-09-22" version="1">MKPILLILILLSTLASAQNTIQPEPVPQLSFVRSADQLTLEAALELAKRSSEKARSFDREVSVAVLDASGTVVLLLRGDGVGPHNTEAARRKAYTALSTKTATLSLLRTSAANPDTHNLNTLPELLLLSGGAPIWYRGNVIGGIGVAGGGSAENDDVIARAAAIPEQGILTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X571</accession>
    <name>C6X571_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix-domain containing protein, AraC type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01109"/>
    <dbReference type="EnsemblBacteria" id="ACU07559">
        <property type="protein sequence ID" value="ACU07559"/>
        <property type="gene ID" value="FIC_01109"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01109"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030864_0_0_10"/>
    <dbReference type="OMA" id="KNDFTHA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970689" evidence="2">
        <location>
            <begin position="21"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="451"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="563" mass="65515" checksum="388DBEAA65D673A6" modified="2009-09-22" version="1">MCNQLMSCMKGLIFFLTVFAVLLTAQDYADFRSRYDHYPNDDPGAFRYVHPYIEKAKREGNYEELTQAYKDAVSFSPEHKIAYADSMISAASRTRNPDLLATAYLTKGTVYYFNYRKYKPALDEYLKAWQYAQHSKSDYLYYKNLYHIGVVKSYLGYYSEALTIFERCKNHFRNPHSEPEPPNIKYNRRKGYLNTLHQEAVSLLHLQRTDKAQAVLESGLAETGAEADYALERSYFYNLQGIVAYRQKRDSAAVTLLATALAGLEKKNDFTHAAIAYYYLGKSSARLGKSEDALRNFAKIDSVFRAHSFILPEVRGAYEFLITYYHHIGNKEQELYYTTQLLKADQIISADFKYLSGKIYKEYDTQDLLESKKRLESTAPFFYLIIGILLAAFMGHALYLYRRRRAEMEIYRQYQSFLLKAQEEQQGVDVPPVALKRHHKIADRSLIKLLHKLETFENSRLFLEKGLTRQRLAAALETNESYLSKVINEYKENNFNGYINRLRIQYITQKLRDSSVHRSFSIEGLAAECGFADRIKFTKAFTEINGMSPREMIRELNREAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X572</accession>
    <name>C6X572_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01110"/>
    <dbReference type="EnsemblBacteria" id="ACU07560">
        <property type="protein sequence ID" value="ACU07560"/>
        <property type="gene ID" value="FIC_01110"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01110"/>
    <dbReference type="eggNOG" id="ENOG5033R94">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079317_0_0_10"/>
    <dbReference type="OMA" id="FATSHDH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018534">
        <property type="entry name" value="Tet_reg_excision_RteC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09357">
        <property type="entry name" value="RteC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="305" mass="36059" checksum="35F1D73A41157F76" modified="2009-09-22" version="1">MFIPKRFFCIFYLKNMTAKLLFRKCEKLYAGLLVMLEKTETSNTDGDAGQYERALMDIDLAIRQLKTWVSGYTFAWVAEEVYFFREIKPKFTALFIYYAKVLATEAAKPNAGQYALKEYYEYELKDLKRFTDEHQDFYEYYRRKATYLDEKYFVRNQFDFKMRIDANLYNYDQDFATSHDHLVAQILAHDRLEKHFLTAIYTIEGYYYDKFSDKSPLTWSGSKSALIELLYALHVTQSFNGGNIDFSETVRFIEKSFNTELGNFYKTLHEIRNRKTGSTKFLAGLTESLKQHFEQAEDQGNVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E2</accession>
    <name>C6X5E2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805915.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01180"/>
    <dbReference type="EnsemblBacteria" id="ACU07630">
        <property type="protein sequence ID" value="ACU07630"/>
        <property type="gene ID" value="FIC_01180"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01180"/>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073333_1_1_10"/>
    <dbReference type="OMA" id="MFRHQGK"/>
    <dbReference type="OrthoDB" id="1751020at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="238" mass="26705" checksum="308192B0117EE6FF" modified="2009-09-22" version="1">MFSHKGKSRTDSHNLGIASILGFVAGMVNIVGFLAVHKLTTNVTGHFAYFVDAALGQNFRNVFYVGFYIFSFFLGAFFSSIVVQIYLRRRENLMYVIPTIVEALILACIAFFGEYLIEANPSVIAFSLLFAMGMQNALVTSISKAVVRTTHLTGLFTDMGIEFAQLFFYKSHAHRNKLFKSIRLRLTIIWMFFGGGVAGGILYGYFGIKTLLFATSILLLGLVYDFLKVRLSLLRHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E9</accession>
    <name>C6X5E9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805922.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01187"/>
    <dbReference type="EnsemblBacteria" id="ACU07637">
        <property type="protein sequence ID" value="ACU07637"/>
        <property type="gene ID" value="FIC_01187"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01187"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121830_0_0_10"/>
    <dbReference type="OMA" id="TIHIKNM"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="186" mass="21236" checksum="416894D1C7DBA2E7" modified="2009-09-22" version="1">MKLYIKNMVCNRCITAVVNIFGDLNIAVSSIRLGEVETEDKLSAKELQLLDNQLRTGGFELLEDSAKRQIEKTKTVIIKEINALDIPDDFVLSKFLSNQLHKEFSAVSKLFSQSENVTLEQYFILQKIEKVKELLLYDEFSLTEISAKLGYRSVQHLSSQFKSVAGYTPSVFKKLKINNRIPLDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F1</accession>
    <name>C6X5F1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein FIC_01189</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805924.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01189"/>
    <dbReference type="EnsemblBacteria" id="ACU07639">
        <property type="protein sequence ID" value="ACU07639"/>
        <property type="gene ID" value="FIC_01189"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01189"/>
    <dbReference type="eggNOG" id="COG3022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061989_1_0_10"/>
    <dbReference type="OMA" id="WKNGQYK"/>
    <dbReference type="OrthoDB" id="1361974at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="252" mass="29328" checksum="E66BAF631C44952D" modified="2009-09-22" version="1">MKILTSPAKLMNTENSTDLLKTTTPVFIEEAALIHSYLKEKDPKYLSQLMEISSKLADENWERNQNWKAKPTAKESAPAMYAFTGEVYRGLDAKTLDQDAVKYLQKNYRIISGLYGLLKPSDRIMLYRLEMGRNFEFENYKNLYEFWREKITAQLNSELKAKDFILNLASGEYIKSLDKTKLNAPLINFDFYEMKGGKPKTIVVYTKHARGMMVRYCAQNQVKTLDQVKGFNLEGYRIDEERSTETNLVFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G4</accession>
    <name>C6X5G4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805937.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01204"/>
    <dbReference type="EnsemblBacteria" id="ACU07652">
        <property type="protein sequence ID" value="ACU07652"/>
        <property type="gene ID" value="FIC_01204"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01204"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_1_1_10"/>
    <dbReference type="OMA" id="AFECGYY"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="145"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="244" mass="28371" checksum="B918865E91217432" modified="2009-09-22" version="1">MKYKKIKPYKELESHIHFYWELRGNEVEKQWERVFPDGCAGIVMNLGDNCLTDNGSTIMEFGKTYVVGAMTSFKDSLIDSDAHLIGVCLKPATFTNFYSYISQNELTNDTVEFEKSNSFNVDKTFENPFNYFDHFYTERIKTKTNQLQSVINDIHSTNGQISIYELSKRHFTTVRQLARNFKRFIGLSPKEYSKIIRFQNALSLIKKSNQNRSLLAIAFECGYYDHSHLNNEFKRNTGLSPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H1</accession>
    <name>C6X5H1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ISBma2, transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01211"/>
    <dbReference type="EnsemblBacteria" id="ACU07659">
        <property type="protein sequence ID" value="ACU07659"/>
        <property type="gene ID" value="FIC_01211"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01211"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021293_3_0_10"/>
    <dbReference type="OMA" id="ADRNYDT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="2">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="322" mass="36550" checksum="796686459CA8BA2E" modified="2009-09-22" version="1">MRGKKKFTPKIFYQLILDALVPEDNFYRKIQSELGLDFLYKATRNYYGKEGQASIDPVVFFKILLVGYLNNINSDRALLRYCSNSLDVRLFLGYDLDEELPWHSTLSRTRQLFGEELFLELFRKVLSLCVEKGMVRGKRQAVDSAFIKANASMDSLVEKEVLEDASAFVDELEENSEFKTTSTRKKLVEQHHAWKEEAYKGMPGNNRSERKDEDGNTIRPKYLSNHTHYSPTDPDAKISVKPGKARQLNYSGQLAVDDAHHVITGACASTSGSKDSVIFPEIMNQTLENLSLNQMQTEEVLADAGYSSGESLKYCKERGINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H5</accession>
    <name>C6X5H5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07663">
        <property type="protein sequence ID" value="ACU07663"/>
        <property type="gene ID" value="FIC_01215"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01215"/>
    <dbReference type="eggNOG" id="ENOG5032ZTT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115784_0_0_10"/>
    <dbReference type="OMA" id="CEMEYEL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="205" mass="23866" checksum="C29D95EDD6AFE73B" modified="2009-09-22" version="1">MLRIKFSAGRQFSASKSASSPSAKTLSAILQKVRNQMKLRLLLIIILLSCKVLSQEKISKNNIYFEDGIAFNSLNNQRFSGIAQYKNKQEHIKFEDVYENGFLLKTLTYYNISSKQIVSDEIIFNPENKRKVSHLRYSSDGKKYWETKFDGNEKKIEFSAYQYGTKILEEKYLNGKKNGIWFCLNDDGTKCEMEYELGKKIKDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J2</accession>
    <name>C6X5J2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805965.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01232"/>
    <dbReference type="EnsemblBacteria" id="ACU07680">
        <property type="protein sequence ID" value="ACU07680"/>
        <property type="gene ID" value="FIC_01232"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01232"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018433_0_0_10"/>
    <dbReference type="OrthoDB" id="1197603at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017647">
        <property type="entry name" value="Dnd_assoc_3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03238">
        <property type="entry name" value="dnd_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="580" mass="67600" checksum="5A6DF1A775173FF5" modified="2009-09-22" version="1">MIKNPLLEELRKLRESSKYAIAQGTYSKLNGFKKYLHIERAVEKKLKSIITKASQANHAQLLLVCGNVGDGKSHILSYLHDELSDDISRFAIHNDATESHNPHESSNETLYKLLGGFKDDQLKDSKDRIILAINLGTLSKFIEEFGEEFKILSDYISSHKILDVDIIHEDEYDSESHFHHVNFTDYHLYSLTENGAISPVISTLLKKIVANEEENSIYKAYLDYKLLNSERSFCPILYNYEFLFSENNRNIISQLIIKAIIQSKEIVSLRTLLNFVYDIIVPVDLSAVNETDYFKTVEKMNVADYLANLIPNYLFEHPELSSLFEKIENLDPKNLRDASTDDVLLTLINAERPLEIFSKYVDQKYLSEIEKKLAQTKVGSADLSGLFMRLNYFSNYYKNEYLRDPDFEQYLIWLFYYHNHHPKYIKKIYHLVEHAARNWNGDPKAGDKVIINVGKKQTQYRVFKDFEVIPELSKKEVKQDNVLHKFTQEFTLTFRINNGTELVKIHVDFSLFKILKMILKGYRPNKRDHNNFVYFIDAVNTLIKQNNSKAALYIDEVNIGKPVDYKFSRDAFSGYKFQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K8</accession>
    <name>C6X5K8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805981.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01248"/>
    <dbReference type="EnsemblBacteria" id="ACU07696">
        <property type="protein sequence ID" value="ACU07696"/>
        <property type="gene ID" value="FIC_01248"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01248"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_10"/>
    <dbReference type="OMA" id="KYIGMCC"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="140"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="308" mass="33813" checksum="AE8CE7F346AC3274" modified="2009-09-22" version="1">MVKFKKLVAIEPLNLIPSAEKELASFAEDVVIYTDRPAGTAEIVARIADADAVLLSYTTTIGEEVLKQCPNIKYIGMCCSLYSPESANVDIPFANKNGITVTGIRDYGDEGVVEYVLSELIRCLHGFGNSPDGTPRKPWDHIPREITGLKAGIIGLGKSGGMIADALHFFGAEISYFSRTRKPEAESKGFRYLPLQELLAQNEVVITCLNKNTVLLHGEEFKQLGHRKILFNTGLSPSWEEEAMKDWLRGDNLLYCDTVDALGSEPLLAHPNVVCMNVSSGRTSQAFGRLSQKVLANLSDYLKKQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P7</accession>
    <name>C6X5P7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="5" type="ordered locus">FIC_01287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806020.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01287"/>
    <dbReference type="EnsemblBacteria" id="ACU07735">
        <property type="protein sequence ID" value="ACU07735"/>
        <property type="gene ID" value="FIC_01287"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01287"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_10"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="184" mass="20469" checksum="80201FFF84A162DC" modified="2009-09-22" version="1">MEEIDLIIDMTKQEMDAALKHLEHAFQKIRAGRASTTMVQDVMVEYYGAPTPLNQVANVMVPDAMTISIQPWDRTAIGAIEKAIINSNLGFAPMNNGENIILNVPPLTEERRRDLAKQAKGEAEATKVTVRNARQDGMKELKKLDGVSEDLVKGGEATVQELTDKYVKLCDDQLKTKEADIMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X7</accession>
    <name>C6X5X7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806100.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01367"/>
    <dbReference type="EnsemblBacteria" id="ACU07815">
        <property type="protein sequence ID" value="ACU07815"/>
        <property type="gene ID" value="FIC_01367"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01367"/>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_2_10"/>
    <dbReference type="OMA" id="YTYDGGH"/>
    <dbReference type="OrthoDB" id="890789at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="280" mass="30049" checksum="BC2B613842553245" modified="2009-09-22" version="1">MKVIIHGGFFSESDKSDEVKTAKQKALKRIVTQAYDYLQKKSAEDTVEYAVSLLEDDELFNAGTGSQIQSDGKIRMSAALMNGDTQKFSGVINIENVRNPIKIAKVLMNEEDSVLGGSGAKKYASEYGFEEFSPETPKRREEYEEKLKNGGKGTVGCVALDADGRLAAATSTGGKGFELAGRISDSATVAGNYANKFCAVSCTGVGEDIVSNATAAKIVTRVTDGLALNEAFQKTFSELKQIDGFAGAIAIDKDGNTFHQDSEPTMVFASYDGENFEVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z1</accession>
    <name>C6X5Z1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M4, thermolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806114.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01381"/>
    <dbReference type="EnsemblBacteria" id="ACU07829">
        <property type="protein sequence ID" value="ACU07829"/>
        <property type="gene ID" value="FIC_01381"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01381"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543665_0_0_10"/>
    <dbReference type="OrthoDB" id="771763at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970721" evidence="1">
        <location>
            <begin position="19"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="GEVED" evidence="3">
        <location>
            <begin position="360"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="465"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="533" mass="55805" checksum="5B0346272765E763" modified="2009-09-22" version="1">MKKVLLSCFLALGFGTQAQLTHVGDFEDATNVSQYAQFGGGTITAAAACSGTLGGQLQIGAINSNNTVVTQTGWMVLTDVLEEEFGKPNNGQAVDVSFNYKKAAGSNGTLYVALFTYLASTNQWSVEYVSPGTVLGTAEITTCAVKTATIPDGKMQPGQSYGIGAWVVGSANGDIYVDDISIMQESVTAAPACTTFTNLANGAVLPSGTNTISWNPSTDAVNYILSVGTTPGGTDVFSGTVAGTSQNVSLAPNTTYYATVSPSNTVGTATGCAVITFSTNNVLSYCALTTNQPSAIAPIKSVTFAMETNTSDATALTIGVFPHYQDFTTTVFEVKDNVTTLPLSILGTTNGNPVNGWAMSAFIDWNEDGDFDDAGESYFNTTATMIRVAGVATNPVPLTGNITIPAGTTYGAKRMRVKYNFSGTSIHTALMSGCAQMGNGQAEDYTLNYQEFLAVGDAAKTTVSVYPNPFTDVLRISDIKGIKSINIVDASGRTVRTMAPAAELNLSNLKSGLYMVTLRYEDGTVKTVKSIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X610</accession>
    <name>C6X610_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein releasing system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806133.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01400"/>
    <dbReference type="EnsemblBacteria" id="ACU07848">
        <property type="protein sequence ID" value="ACU07848"/>
        <property type="gene ID" value="FIC_01400"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01400"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OMA" id="APIWVRR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="24670" checksum="6E7CA183BD6C3527" modified="2009-09-22" version="1">MIRAKNIHKSYGDLEVLKGVDIHILEGEVVSIVGESGAGKSTLLQILGTLDTPSTPKNFQTEIALDGKSFISMSDRQLSKFRNENIGFVFQFHQLLPEFSALENVLLPTRISGKNEKESLDKAYSLFEDLNIAHRLHHKPGEMSGGEAQRAAVARALINSPKIIFADEPTGNLDSKNADDLHQLFFDLRDKYNQTFVIVTHNMHLANTTDRKLVMKDGQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X650</accession>
    <name>C6X650_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menB</name>
        <name evidence="4" type="ordered locus">FIC_01440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806173.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01440"/>
    <dbReference type="EnsemblBacteria" id="ACU07888">
        <property type="protein sequence ID" value="ACU07888"/>
        <property type="gene ID" value="FIC_01440"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01440"/>
    <dbReference type="eggNOG" id="COG0447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_7_10"/>
    <dbReference type="OMA" id="IFKQTDA"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="77"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="278" mass="30904" checksum="79EF7DEC7C0868ED" modified="2009-09-22" version="1">MTDWKTVKEYEDITYQKRGAVARIAFNRPEVRNAFRPKTTSELYDAFYHVSEDASVGVVLLTGEGPSPKDGGHAFCSGGDQKARGEQGYVGDDGRHRLNILEVQRLIRFMPKVVIAVVNGWAVGGGHSLHVVCDLTLASEEHAIFKQTDADVTSFDGGYGSAYLAKMVGQKKAREIFFLGRNYSAREAEAMGMVNAIFPHAELEDKAYEWAQEILGKSPMSIRMLKFAMNLTDDGMVGQQVFAGEATRLAYMTDEAKEGRNAFLEKRKPDFGENKWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X672</accession>
    <name>C6X672_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secreted peptidase, family S9</fullName>
            <ecNumber evidence="6">3.4.21.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.83" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806195.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01462"/>
    <dbReference type="MEROPS" id="S09.010"/>
    <dbReference type="EnsemblBacteria" id="ACU07910">
        <property type="protein sequence ID" value="ACU07910"/>
        <property type="gene ID" value="FIC_01462"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01462"/>
    <dbReference type="eggNOG" id="COG1770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_0_1_10"/>
    <dbReference type="OMA" id="FPRIAMT"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973641" evidence="3">
        <location>
            <begin position="19"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9_N" evidence="5">
        <location>
            <begin position="26"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="491"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="708" mass="81084" checksum="9AAF3878271CEE9A" modified="2009-09-22" version="1">MKKTIAASLLSLTCIMNAQTWPDAKPPVAEKQNHVRDIHGDKVADPYYWMIDYFKKGKDSTKVVDYLTAENAYLETMMADTKPLREKLYEEMKARIKEKDESVPVFKNGYYYYTRTETGKQYYKYCRKKGNLDATEEVLLDVDKMAEGKPYFSAVNFNISPDNNLMTFGVDYISRRQYKIFLKDLRTGKVTDLGIKNTEGDAIWAADNKTLFYTAKNDVTLLSEKIKRHTLGSDPAKDAVVYEEKDKSNYLGVAKSKNEKYIFIYSAATTSSEIRYLPTDQPNTAFRVFQPRMKDVLYDVFPLEDKFLIVTNKDALNFKVMETPLNKTEFENWKEVIPHRKDVLVQGIDEFKNFLVFSERQNGLSQLVIQDRKTQKKEFLKFDEPTYIVRSSGNPEYNTDNFRFTYASMITPSSQYEQDLVTGKRTLLKQQEVLGGYDKTQYVTERLFATAKDGTSIPLSVVYKKGFAKNGKNPLLLYGYGSYGNSMEAGFSSARLSLLNRGFAYVMTHIRGGQEMGRQWYEDGKMMKKINTFTDFIDAGEYLVKEKYTSPQHLYAQGGSAGGLLMGAVINMKPELFNGVVAQVPFVDVVNTMLDESIPLTTNEYDEWGNPNNAEAYRYMKSYSPYENIGRKNYPNLLITTGLHDSQVQYFEPAKWAAKLRDLKTGNNVVLLKTEMAFGHGGASGRFDFLKDVAWDYAFLLKLEGINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X688</accession>
    <name>C6X688_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01478"/>
    <dbReference type="EnsemblBacteria" id="ACU07926">
        <property type="protein sequence ID" value="ACU07926"/>
        <property type="gene ID" value="FIC_01478"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01478"/>
    <dbReference type="eggNOG" id="ENOG502Z9A2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086263_0_0_10"/>
    <dbReference type="OMA" id="YLETPTW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011727">
        <property type="entry name" value="CHP02117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09601">
        <property type="entry name" value="DUF2459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02117">
        <property type="entry name" value="chp_urease_rgn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="253" mass="28789" checksum="08562ADF47673D45" modified="2009-09-22" version="1">MYLKVLINRELHSVGGRSFHFLFLIHLFMKKFLLAVLKSIGVILGIIVVYVILVLLIPYIPVAKKPVAERPDIAVYILTNGMHTDVVMPVHSKIINWNDEIPTGKTRSGRTDYRYISIGWGDKGFYLDTPTWAELKPSTAVKAAFWLSESAMHCTYYDKMTESEDCRKIMLTEKQYAALAEFVKSKFDRDQNGKPIFVKTDAVYGKDDTFYDAQGSYSFLNTCNTWTNNALKAAGQKAALWTATDFGIFQHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X698</accession>
    <name>C6X698_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806221.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01489"/>
    <dbReference type="EnsemblBacteria" id="ACU07936">
        <property type="protein sequence ID" value="ACU07936"/>
        <property type="gene ID" value="FIC_01489"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01489"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_11_1_10"/>
    <dbReference type="OMA" id="ELWESVE"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="97" mass="11385" checksum="C4E42C510843206B" modified="2009-09-22" version="1">MNRLYIVALFHFKENYLDEALQLLEKLVAGTRKEEGCLQYDLVEDVDNKGIFFLMELWETAELHRQHSASEHLSEFRKNAAPLFESSTEVYRGSKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D1</accession>
    <name>C6X6D1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806254.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01522"/>
    <dbReference type="EnsemblBacteria" id="ACU07969">
        <property type="protein sequence ID" value="ACU07969"/>
        <property type="gene ID" value="FIC_01522"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01522"/>
    <dbReference type="eggNOG" id="COG4099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064094_1_0_10"/>
    <dbReference type="OMA" id="PIWVFHG"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973647" evidence="1">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_2" evidence="2">
        <location>
            <begin position="106"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="236" mass="26934" checksum="63F86568FC4B4288" modified="2009-09-22" version="1">MKKLSRFLPLLILFFAGNLSSQEIKSALNKQITEIKQISYVLDYPQNAKGNVPLIVFLHGSGERGTDLDKVKTNGPFQYKNLIPEPVAILAPQCPDGVWWDTEAVYHLIKDIQQKYKIDESRIILTGLSMGGWGTLKLAMEHPEMFSAVVPVCPPVDRLMKVRATQYKDLPMKIFHGGNDDIVSPMNSIEIYQEIRKTNKNVELIIFPDDNHNSWDSTYSNAKLYEWMLAKSKKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G9</accession>
    <name>C6X6G9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01560"/>
    <dbReference type="EnsemblBacteria" id="ACU08007">
        <property type="protein sequence ID" value="ACU08007"/>
        <property type="gene ID" value="FIC_01560"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01560"/>
    <dbReference type="HOGENOM" id="CLU_3365105_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="4383" checksum="AE274A4E0B9A5195" modified="2009-09-22" version="1">MLEFDVCIFAIETYKKIPENIFRDFFVVNMRIHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H9</accession>
    <name>C6X6H9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806302.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01570"/>
    <dbReference type="EnsemblBacteria" id="ACU08017">
        <property type="protein sequence ID" value="ACU08017"/>
        <property type="gene ID" value="FIC_01570"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01570"/>
    <dbReference type="eggNOG" id="ENOG5031C6A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136707_1_0_10"/>
    <dbReference type="OMA" id="WEGEISQ"/>
    <dbReference type="OrthoDB" id="1860536at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="14020" checksum="F648499A72D7716C" modified="2009-09-22" version="1">MRYLWIVLVAVVLVLCGVVYYKYYFVFGEGVKSGILNYAVKKGNIFKTYEGKLIQEGFGTNAKTGSLTSYEFEFSIEDEEIFKQLEINNGKTFDLHYKEYHGALPWRGNTTYVVDRIVNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB3</accession>
    <name>C6WZB3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00523"/>
    <dbReference type="EnsemblBacteria" id="ACU06981">
        <property type="protein sequence ID" value="ACU06981"/>
        <property type="gene ID" value="FIC_00523"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00523"/>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_2_1_10"/>
    <dbReference type="OMA" id="DNGLTEH"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="171" mass="19995" checksum="95C28739F4FFF10B" modified="2009-09-22" version="1">MKMEEHVVLVSEQDEVLGVMEKMQAHQEGILHRAFSVFLFNEAGEMLLQKRAAGKYHSPNQWTNAVCSHPRIDESYLEGANRRMSEELGIDAELQEKFHFIYKADVGQDLWEHELDHVFTGSFSGDVNLNKDEVAEIRYISMEDLDNEMNEHPENFTEWFKIILGEYKHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB4</accession>
    <name>C6WZB4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00524"/>
    <dbReference type="EnsemblBacteria" id="ACU06982">
        <property type="protein sequence ID" value="ACU06982"/>
        <property type="gene ID" value="FIC_00524"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00524"/>
    <dbReference type="eggNOG" id="COG0647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1841495_0_0_10"/>
    <dbReference type="OMA" id="PERMATC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="141" mass="16634" checksum="DA422B0A525217E3" modified="2009-09-22" version="1">MPLQKILQMELEYKDHLSPMLKGDIKNYLIDIDGTITDDVPNEEPERMVDCVPYPDALETINRWYDQGHIICFFTSRTENLKQITIDWLDKHGFKYHSVLCGKPRGGNYHWIDNHLVKATRYKGKFTDMVEKQVTIEVFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC9</accession>
    <name>C6WZC9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, C-terminal section</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782110.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00505"/>
    <dbReference type="EnsemblBacteria" id="ACU06963">
        <property type="protein sequence ID" value="ACU06963"/>
        <property type="gene ID" value="FIC_00505"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00505"/>
    <dbReference type="eggNOG" id="COG3958">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_10"/>
    <dbReference type="OMA" id="VINTCDY"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="315" mass="34155" checksum="A374880D1DC97D67" modified="2009-09-22" version="1">MKFTYTEKKDTRSGFGAGLAELADNNPNVVALCADLIGSLKMEKFIEKAPERFIQVGIAEANMMGIAAGLTINGKIPFTGTFANFSTSRVYDQIRQSIAYSNKNVKICASHAGLTLGEDGATHQVLEDIGMMKMLPGMTVINTCDYNQTKAATLAIADFEGPVYLRFGRPVVPVFIPEDMPFEIGKGIMLQEGTDVTIVATGHLVWESLVAADELEKEGISCEVINIHTIKPLDEEIILKSVAKTGKIITAEEHNYLGGLGESVAGMLSRKRPTLQEFVAVNDTFGESATPAELMKKYEIDADAVKAAVKRIMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD5</accession>
    <name>C6WZD5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782113.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06966">
        <property type="protein sequence ID" value="ACU06966"/>
        <property type="gene ID" value="FIC_00508"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00508"/>
    <dbReference type="HOGENOM" id="CLU_2584592_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="80" mass="8468" checksum="0AD74A685ABEB737" modified="2009-09-22" version="1">MTRSNLLTKIQFFALALVANFATILVKAQDGAADLKVDVDVDKGGAMGDGWMSNPLVWVIGALILIVIIALVARGNGNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE4</accession>
    <name>C6WZE4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781626.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00001"/>
    <dbReference type="EnsemblBacteria" id="ACU06479">
        <property type="protein sequence ID" value="ACU06479"/>
        <property type="gene ID" value="FIC_00001"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00001"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_10"/>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="142" mass="15783" checksum="AD55EC2F64E04AA6" modified="2009-09-22" version="1">MKKISIASDHAGYAYKEAIKKHFAGQYQIEDFGTFSEDSVDYPDFVHPSAESVETGRNELGILICGSGNGVQMTANKHKAIRCALCWMPELAELARKHNNANMIALPARFIAVELAIDVVEKFLTTDFEAGRHQLRVDKIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL0</accession>
    <name>C6WZL0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781692.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00069"/>
    <dbReference type="EnsemblBacteria" id="ACU06545">
        <property type="protein sequence ID" value="ACU06545"/>
        <property type="gene ID" value="FIC_00069"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00069"/>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068039_0_0_10"/>
    <dbReference type="OMA" id="YNSAYAN"/>
    <dbReference type="OrthoDB" id="1256747at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970467" evidence="2">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="3">
        <location>
            <begin position="34"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="324" mass="37264" checksum="8CAF525581451925" modified="2009-09-22" version="1">MKKYLIVLLAFFALSACNRQQDLAMKSADKDYILKVANENFENKKWTDALALYERLSNLVAGTDDAPNVVYNSAYANYYDKNYKLAGHQFKNFSVTFPQDPRAEDAAYMSALCFYEGSMDYNLDQTSTELAINELQNFLNNYPNSEKSKNINELIDELTYKLEFKAYENARQYFKMADYKAANVAFENVLYDFPSTKLSPKINEYILRSKYELAVNSVYDLKKDRIESALAFTKQVERDTPNTENAKLAAELRTKLTKEKTAFLELEQKVEQRKKEIQDKQKAEEARLNAEKDQRDAEKNANQIARDSAALATPPPAATFDIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL2</accession>
    <name>C6WZL2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TatD-related deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781694.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00071"/>
    <dbReference type="EnsemblBacteria" id="ACU06547">
        <property type="protein sequence ID" value="ACU06547"/>
        <property type="gene ID" value="FIC_00071"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00071"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_6_0_10"/>
    <dbReference type="OMA" id="SIGIHPW"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="208" mass="23906" checksum="7FB180FC4707DE4F" modified="2009-09-22" version="1">MQHFDFHHHDPAQEHGIYNLKYEEELPTGLFSAGIHPDSVEDHLEEKMVWLHKVAQAENCVAIGECGLDGRFLTDALQEDVFRRQILLANQLQKPLIIHCVKRFPALIRYKKSAKVPMIIHGFNKRETIGRELLMHNFYLSFGKSLLYNVDLQGFLKDIPLNRLFLETDSADVDLQEIYEKAAALKNIGTGEMAEQIKLNLLSLKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN3</accession>
    <name>C6WZN3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781715.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00092"/>
    <dbReference type="EnsemblBacteria" id="ACU06568">
        <property type="protein sequence ID" value="ACU06568"/>
        <property type="gene ID" value="FIC_00092"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00092"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_10"/>
    <dbReference type="OMA" id="CRVISPI"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="101" mass="11153" checksum="2978E65E23460CF5" modified="2009-09-22" version="1">MSQKFHELINSERPVLIDFFATWCGPCKVQSSVLTTVKENIGDLARIVKIDVDQFPAIAAEYGVRGVPTLAVFRNGEMLWKESGVHDVNTLTGLLKDFAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ1</accession>
    <name>C6WZQ1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00111"/>
    <dbReference type="EnsemblBacteria" id="ACU06586">
        <property type="protein sequence ID" value="ACU06586"/>
        <property type="gene ID" value="FIC_00111"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00111"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313882_0_0_10"/>
    <dbReference type="OMA" id="FTFNRQA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973417" evidence="1">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="24214" checksum="A7945817B4FE8157" modified="2009-09-22" version="1">MSAKLFFLIVFFAAPFLPAQQNEEFAATKKFFDYQRFMLNQEFKKQYEKQKNAQNKLESKQDYSEFMQKLDSIQNKAYINTLIKVKNREDLSRLSAQTLPALHLKNPIKEELSADAQYPGGFEMLRAQVADLFYSESVLPHQKLLKTDVVFVVEKDGSISEVQAQGDNFTFNRQAEIAVYLLPDKFSPATINGHAVRYRFRLPLTMSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ6</accession>
    <name>C6WZQ6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muconate cycloisomerase</fullName>
            <ecNumber evidence="2">5.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00116"/>
    <dbReference type="EnsemblBacteria" id="ACU06591">
        <property type="protein sequence ID" value="ACU06591"/>
        <property type="gene ID" value="FIC_00116"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00116"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_3_10"/>
    <dbReference type="OMA" id="FIGRGEC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018849">
        <property type="term" value="F:muconate cycloisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE_C" evidence="1">
        <location>
            <begin position="170"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="358" mass="40660" checksum="7EAF165472D04B5E" modified="2009-09-22" version="1">MFTFKNKQISLTFVFILNISENQHCMKLSWKREILYLKETFSIAHGKYNFRETLVVMLASHGETGYGECVAIDYYGIDLDVFVLKLHEIKQEIESAPMVVPQDFYTFLTTLNLHSFLSSALDCAYWDLFGKLENKSFFQLNDLNGNLPESSFTISVSPVEEQVRKILASPWQNFKVKCNGLNRADIFKLLETGKEIALDSNTSFSEDDCRFLQENELTKNFVYIEQPRPVGEYRILNKNLYANWMADEDCQDISYLEKLRPHYSAINVKLMKCGGLTPALELIREARKLKFKVMIGCMTESSVGISAGIALAPLCDYADLDGANLISNDFSEGSSVENGRLLLSEKPGLGISMRKTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR2</accession>
    <name>C6WZR2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00122"/>
    <dbReference type="EnsemblBacteria" id="ACU06597">
        <property type="protein sequence ID" value="ACU06597"/>
        <property type="gene ID" value="FIC_00122"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00122"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OMA" id="PKYLFCD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="289" mass="33058" checksum="420D41794CB143C6" modified="2009-09-22" version="1">MDHCCNYYYEFNFNPNVPQLMIEVKDLKKSFEEVEVLKGITTTFETGKVNLIIGQSGSGKTVFLKSLLNVYQPTSGGILFDGRDINNMSRDEKQTLRSEIGTVFQGSALFDSMTVEENITFPLDMFTNLTYREKKRRAFEVIGRVHLEKANRKYPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPYTANIIDDLLLEITKEYNTTTIINSHDMNSVMTIGEKIVYLRLGIKEWEGNKDILINAGNKNLIDFVYSSELFKELREYFLETNKTSIDNVTTNPQENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT2</accession>
    <name>C6WZT2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781764.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00142"/>
    <dbReference type="EnsemblBacteria" id="ACU06617">
        <property type="protein sequence ID" value="ACU06617"/>
        <property type="gene ID" value="FIC_00142"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00142"/>
    <dbReference type="eggNOG" id="COG3198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142165_1_0_10"/>
    <dbReference type="OMA" id="KINWGTG"/>
    <dbReference type="OrthoDB" id="1712403at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008620">
        <property type="entry name" value="FixH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05751">
        <property type="entry name" value="FixH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="151" mass="17441" checksum="5460CC7B4764651E" modified="2009-09-22" version="1">MFKNFSWGHGVAVALGSFIIFILFLIFVFSRGMQNSELISENYYQDELAYQDVIDAKNNADLLAEKPVYAQNSQGITITFPQSVAPENMKAEFDLFRTDDSNLDVHKEITLNSQKKFTIPRNVILAGSYTLKLKWQKDKKPYQVDYDVLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU7</accession>
    <name>C6WZU7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HU-CCDC81_bac_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00157"/>
    <dbReference type="EnsemblBacteria" id="ACU06632">
        <property type="protein sequence ID" value="ACU06632"/>
        <property type="gene ID" value="FIC_00157"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00157"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1223973_0_0_10"/>
    <dbReference type="OMA" id="NIANCIL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041268">
        <property type="entry name" value="HU-CCDC81_bac_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18175">
        <property type="entry name" value="HU-CCDC81_bac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HU-CCDC81_bac_2" evidence="3">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="26079" checksum="13ACBB46E4E24812" modified="2009-09-22" version="1">MRPMSFPSLILEFLKNHAEVSVAGFGILYLKNINALVETDRKSILPPGKEVAFKNTTDTTDLDFASFLASQRNISIDEAEAEIKKHVVFWNSTLEKEGTLTVEGIGTFSLNDSKIHFSGARLNNATPDFYGLEEINLADISKRSQQNSGNGKPYRVSTSWFWLTALIIAVAAISYLGISQPEEIFGKKSFAKPLEEQPRPTASVKAISTDSTLARKAADSTKTDSVSVSGGAAPIFKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW2</accession>
    <name>C6WZW2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781794.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00172"/>
    <dbReference type="EnsemblBacteria" id="ACU06647">
        <property type="protein sequence ID" value="ACU06647"/>
        <property type="gene ID" value="FIC_00172"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00172"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_10"/>
    <dbReference type="OMA" id="VKSRMRY"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="196" mass="23242" checksum="7A3D27A182C2CC0B" modified="2009-09-22" version="1">MKTHSDSWLISEYRSGNEKTLAVLIERHQKDLFSFIFYKLMDEDLANDIFQDTFMKIIVTLKEGRYNEEGKFILWAKRIAHNLIIDHFRLKSKHIKVSETSYDNDEFSIFDLISGNEENIEEQLVSRQIQEDLMKMLVYLPANQQEVIRLRFFDGLSFKEIADQTDSSINTTLGRVRYALINLRKIMDEHNIILTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW9</accession>
    <name>C6WZW9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaK suppressor protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781801.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00179"/>
    <dbReference type="EnsemblBacteria" id="ACU06654">
        <property type="protein sequence ID" value="ACU06654"/>
        <property type="gene ID" value="FIC_00179"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00179"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_3_1_10"/>
    <dbReference type="OMA" id="IEAKNMQ"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="126" mass="14471" checksum="CF9C306D97FAD8F1" modified="2009-09-22" version="1">MTEGRQRYSDADLMEFKELIQQKIEKAERDLMLIRESFINDQNNGTDDTSPTFKAFEEGAETLSKEQNAILAGRQEKFVRDLKNALIRIQNKTYGICRVTGKLIGKDRLRAVPHATLSIEAKNLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X092</accession>
    <name>C6X092_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06777">
        <property type="protein sequence ID" value="ACU06777"/>
        <property type="gene ID" value="FIC_00310"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00310"/>
    <dbReference type="HOGENOM" id="CLU_3356316_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="36" mass="4489" checksum="E87BF6EFEB04245A" modified="2009-09-22" version="1">MHKGKDFSAFFGYKTLKPRERKKFGKDYFIYLHIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C2</accession>
    <name>C6X0C2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00340"/>
    <dbReference type="EnsemblBacteria" id="ACU06807">
        <property type="protein sequence ID" value="ACU06807"/>
        <property type="gene ID" value="FIC_00340"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00340"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056705_0_0_10"/>
    <dbReference type="OMA" id="LKKNMYY"/>
    <dbReference type="OrthoDB" id="1405766at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029465">
        <property type="entry name" value="ATPgrasp_TupA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14305">
        <property type="entry name" value="ATPgrasp_TupA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="321" mass="37980" checksum="B0E96B88CDFBCE3A" modified="2009-09-22" version="1">MALVSNYIQKIKNMTIRNYLVGLKNTNAFLYYVWSRNQQRKGVLDLKYVSDVAAVTRLYKRYAGKSPDLINPQTFSEKMQWLKLNYHHDLMTVCADKYEVRDYIKEKGYGHILSEIIGVYTRVDDIPFTSLPKQFVVKATHGSGWNLICKDKTRVNWYWWKKTFGIWLNSNIFWPGREWPYKNMPARILVEKFLTDKSGQLMDYKFFCFNGKVHFVQANKGRDTANHAQNFYDLEWNILPFGKDLEPRPDIDIEPPTKLREMAEIAEDLAQPFPFVRMDFYEVEEKIIFGEMTFYPKSGLPDFTPIEYDRIFGELLKIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C5</accession>
    <name>C6X0C5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative capsular polysaccharide biosynthesis protein YveQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781957.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00343"/>
    <dbReference type="EnsemblBacteria" id="ACU06810">
        <property type="protein sequence ID" value="ACU06810"/>
        <property type="gene ID" value="FIC_00343"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00343"/>
    <dbReference type="eggNOG" id="ENOG5033A5I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059692_2_0_10"/>
    <dbReference type="OMA" id="HMASESA"/>
    <dbReference type="OrthoDB" id="1499314at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="355" mass="39865" checksum="3C1C7C2618A8E822" modified="2009-09-22" version="1">MFIYFIILGLVLLLLWGQNSSENSSILNLPALLAVGILIAFAGLRNVNVGTDTGNYVGIYYGYQDILASGQVITSNMEKGYIALMYVATGISTDYWAVLLLTAIICVGTYMYVIFKVSENVALSVFIYVVLGTYLVFFNAARQGLAISICAISVIFLLQRKIWHYIIVIIIASFFHRTALILLPFYFILRLPFSYRNTGIFVVAGAASFYFLSTILSLFDSDTEMRYGQYEERGATGGQLLSLFYILSSALLIYARKFIAADKIRLYDVFLNYSIFTAIIYFVVIATGSDVNFMRLTNYFAVGYVFGYPLILKSLNNITGALVKPLFIVAHLLFFAVYLSRMANLTPYYPNLNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E3</accession>
    <name>C6X0E3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00361"/>
    <dbReference type="EnsemblBacteria" id="ACU06828">
        <property type="protein sequence ID" value="ACU06828"/>
        <property type="gene ID" value="FIC_00361"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00361"/>
    <dbReference type="HOGENOM" id="CLU_3403659_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="30" mass="3310" checksum="D99881621171EC41" modified="2009-09-22" version="1">MKGKRNNFVENIANLEIIPSKVGFFPADGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G5</accession>
    <name>C6X0G5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ordered locus">FIC_00384</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781998.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00384"/>
    <dbReference type="EnsemblBacteria" id="ACU06851">
        <property type="protein sequence ID" value="ACU06851"/>
        <property type="gene ID" value="FIC_00384"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00384"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_3_0_10"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU06851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="184" mass="20313" checksum="551BB11313473C66" modified="2009-09-22" version="1">MQTEKIILGIDPGTTIMGFGLISVVKGKMEMLSIHELILKKYPNHETKLKVIFDRTLALIDEFHPDEVALEAPFFGKNVQSMLKLGRAQGVAMAAALHRDIPITEYSPKKIKMAITGNGNASKEQVAGMLQSLLNLKEFPTKYLDASDGLAVAVCHHFNSGALVSDKNYSGWDSFLKQNPDRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G6</accession>
    <name>C6X0G6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781999.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00385"/>
    <dbReference type="EnsemblBacteria" id="ACU06852">
        <property type="protein sequence ID" value="ACU06852"/>
        <property type="gene ID" value="FIC_00385"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00385"/>
    <dbReference type="eggNOG" id="COG4192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046542_0_0_10"/>
    <dbReference type="OMA" id="WGLAIFN"/>
    <dbReference type="OrthoDB" id="1540624at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025519">
        <property type="entry name" value="DUF4407"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14362">
        <property type="entry name" value="DUF4407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="363" mass="41325" checksum="B782861BB58F0B13" modified="2009-09-22" version="1">MKNVPSNIPPVNHRMNWFQKFLLICSGGNIHILRKTPSEWNKFAGIGGIVLFTAIFATLSAGYAMYTVFDDIWISVAFAVVWGLMIFNLDRYIVSSIKKTGTWWNQLLMSVPRLVLAAFLGIIISKPLELKIFEKEVNKQLNTIIQRNKTQLQAEMNGRILQQSGPFETEKKQISTKIADYQRSYDSAAVELEKEILGKQSGLTSGKVGFGTNAKRKAELKEQRRQDLENYQKTIAPRLDYLDKEISKVYTNIETERNKTETFEDRFNGFAARLQALDELGKNTAIIGVAAAFIMGLFICLEISPVLVKLISSVGPYDYLLEKTENDFRLYSKEKIEKGNAGTDWRIDDFKNQLTQNKNQPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0H0</accession>
    <name>C6X0H0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00389"/>
    <dbReference type="EnsemblBacteria" id="ACU06856">
        <property type="protein sequence ID" value="ACU06856"/>
        <property type="gene ID" value="FIC_00389"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00389"/>
    <dbReference type="HOGENOM" id="CLU_1649606_0_0_10"/>
    <dbReference type="OMA" id="NTEREYN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="160" mass="17549" checksum="6A144DC71B2F786A" modified="2009-09-22" version="1">MIGFIGLNLSVMKKFTPFYLFCVLLLAVQCGTLPGGGIYRPGNTGSGTSVNESGEFAELIAKDQINKTQETADVLNYLLNDDEPADPYTAIVLENTSSCDIIVRVVQVSGGRIYNFPVPRNAKNHFKIAKGNYTLKSNICEAKYYSQKNISEALIITLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0H2</accession>
    <name>C6X0H2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage tail collar domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782005.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00391"/>
    <dbReference type="EnsemblBacteria" id="ACU06858">
        <property type="protein sequence ID" value="ACU06858"/>
        <property type="gene ID" value="FIC_00391"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00391"/>
    <dbReference type="eggNOG" id="COG4675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087872_0_0_10"/>
    <dbReference type="OMA" id="NFQPYLC"/>
    <dbReference type="OrthoDB" id="1837650at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011083">
        <property type="entry name" value="Phage_tail_collar_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07484">
        <property type="entry name" value="Collar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973537" evidence="2">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Collar" evidence="3">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="193" mass="20719" checksum="5C67150808FEB27D" modified="2009-09-22" version="1">MKKLYHAVLVAWMPFVAPLAAQDNFVGQIMFVPYNFSPQGWHNCDGSLLSISENEVLFTLIGTTYGGDGQTTFAVPDMRGRVMIDDGQGNTLSSFTLGQMSGTETVQLTQAQMPAHSHTVNAVSGAGTSESPTSHLPANTGILDKEYSNQPLTSTMKMGMLSAAGGSQPHNNIQPYLTMKCVIALYGIYPPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K5</accession>
    <name>C6X0K5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="9" type="ordered locus">FIC_00429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00429"/>
    <dbReference type="EnsemblBacteria" id="ACU06891">
        <property type="protein sequence ID" value="ACU06891"/>
        <property type="gene ID" value="FIC_00429"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00429"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_10"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="7">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="8">
        <location>
            <begin position="275"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="611" mass="71093" checksum="DD94B081200AC82A" modified="2009-09-22" version="1">MSIRVYVFPYFCIMNSNLELQLKTLPSEPGVYRYYDKNDQLLYVGKAKHLKKRVLSYFNKNLPGYRTRIMVAKIHRLETTIVPSEYDALLLENNLIKEHQPFYNVMLKDDKSYPWICIKNEDFPRIFLTRTMIKDGSEYYGPYARVRPAKVLLDTIKHIYKLRTCTLNLSPPKIAEGKYKVCLEFHIKNCQGPCEMLESKEDYDLKIDAIRGIIKGDFKRAKEYLVNQMMKYAENLQFEDAHVVKERLDMLENYQHKHTVVNPNIDDVDVFGMTSDETAAYVNYFKIQNGNIIQSFTTEIKKILDESDEDILEEAMIEIRQKFNSDSKEILLPFHLTLEIPNVKLIVPKVGDKKRIVELSEKNAKEYRIEKLKAVQIVDPERHTNRIMAEMQKLLRMPVEPRHIEGFDNSNIQGTNPVSACVVFKNGKPSKADYRIFHPKTVEGANDFATMEEVIHRRYRRLLEENSPLPQLILIDGGKGQLSSAVKSLKLLGLYGKITIIGIAKRLEEIYFPEDPIPLYLDKKSETLKILQRVRDESHRFGVKHHRTRRKNSTIKSELEEIPGIGEKAVDLLLSKLKSVKRVKESSRETLEEILGKSRGGLVWEYFNTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K9</accession>
    <name>C6X0K9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylcrotonyl-CoA carboxylase carboxyl transferase subunit</fullName>
            <ecNumber evidence="4">6.4.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.4" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782042.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00433"/>
    <dbReference type="EnsemblBacteria" id="ACU06895">
        <property type="protein sequence ID" value="ACU06895"/>
        <property type="gene ID" value="FIC_00433"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00433"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_10"/>
    <dbReference type="OMA" id="AYLPIMS"/>
    <dbReference type="OrthoDB" id="123223at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="273"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="542" mass="59633" checksum="83F007971C58D8D4" modified="2009-09-22" version="1">MDLEFNKREDQNKLKLAEINRLLAQIKKGGGEQRLQKQRDEGKLTARERIEYLLDKNSESIEIGAFAGFEMYEEHGGCPGGGVIVVMGYVSGKQCLVVANDASVKAGAWFPITAKKNLRAQEISMENRLPIIYLVDSAGVYLPMQDEIFPDKEHFGRIFRNNAKMSAMGIIQISAVMGSCVAGGAYLPIMSDEAMIVDKTGSIFLAGSYLVKAAIGENIDNETLGGATTHCEISGVTDYKAKDDQDALNRIKNIMKSIGSYEKAGFDRIESFPPKEKIENIFGHMPDSRADQYDTFNIIKCLVDHSEFEEYKPDYGKTIICATARIDGWSVGIVANQRKLVKNGKGEMQFGGVIYSDSADKATRFIANCNQRKIPLIFLQDVTGFMVGSKSEHGGIIKDGAKMVNAVANSVVPKFTVITGNSYGAGNYAMCGKAYDPRLIVAWPWSDLAVMGGSQAAKVLAQIQESTLKKQGKEITPEEHQEILDTISKRYKKQTEPTYAAARLWTDAIINPVDTRTWISMGIEAANHAPITEKFNLGVIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M9</accession>
    <name>C6X0M9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00453"/>
    <dbReference type="EnsemblBacteria" id="ACU06915">
        <property type="protein sequence ID" value="ACU06915"/>
        <property type="gene ID" value="FIC_00453"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00453"/>
    <dbReference type="eggNOG" id="ENOG5032ZGC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591539_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="462" mass="53995" checksum="D39686DC0A48C7AB" modified="2009-09-22" version="1">MMTYNFHNNPVKNLNKSSIQLINECYDNHLKIDLRSIHTELNSYSSENDHQLGINDLDVITNPIRFTNSKSEVFQLISYQNKNYLISESSCFPCSKVIENIDGDRWVFILLIPDGDKIFIDNVNSSVKYSFYNLKFFDFLTSIEDLVAFDKTYCNTFSQNKWFTSTERIQLIVRSKANENDILNTLLKLKLLNAFQFSVITIVNNLNINTHDVLNYVLNNDSISLSLPYITSPNFKIKISDSTTKMLKSEDFTIFINSLNGEEVKQFFEIDFLEEQLILENIYPEFKSDILGIKILERWYTAGVKGNVAQCFQERLGTTNISKNLIREYYQKLKNNLRLIENKIRSEKGYNIVGSLYNESLLFSLIQKVFPNYEIISQYSPEWLGRQRIDIFIKELNLAIEYNGKQHYEAVKYFGGDEGLKKTIYRDNIKKKKCVQNGCKLMIVKYDEDLHEFVNNLKTENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P1</accession>
    <name>C6X0P1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical nudix hydrolase YeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782074.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00465"/>
    <dbReference type="EnsemblBacteria" id="ACU06927">
        <property type="protein sequence ID" value="ACU06927"/>
        <property type="gene ID" value="FIC_00465"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00465"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_3_10"/>
    <dbReference type="OMA" id="YYIWGAT"/>
    <dbReference type="OrthoDB" id="1623169at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="24100" checksum="81D4F32B73177AF8" modified="2009-09-22" version="1">MEMFGRDLVKKIQDAELPGENAHGIYSPPYRPIFSYEEILARNPKFAAVNILLYLKDNEWYFPLIVRSTHERDRHSGQISLPGGKKEDFDPDFAQTAKRETSEEVGIEEHYIRIIREMSPMYIPPSNFYVKTFVSYTKKNPVFLLQESEAVELIEFPVGSLLNLDDKPQMMVLPSTRGVEVPVIDFNGYLIWGATSMILSEFSNLMKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S6</accession>
    <name>C6X0S6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806324.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01593"/>
    <dbReference type="EnsemblBacteria" id="ACU08039">
        <property type="protein sequence ID" value="ACU08039"/>
        <property type="gene ID" value="FIC_01593"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01593"/>
    <dbReference type="eggNOG" id="ENOG502ZRUR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142853_0_0_10"/>
    <dbReference type="OMA" id="CTLSEEM"/>
    <dbReference type="OrthoDB" id="1724320at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011463">
        <property type="entry name" value="DUF1569"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07606">
        <property type="entry name" value="DUF1569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="151" mass="17378" checksum="865D9B8DDBD633DE" modified="2009-09-22" version="1">MQNIFDARDAQNYISRINTLTPETQGKWGVMSVDQVLAHLNVAFEIAFEPHKFKKMGSIAKFIMKNFVKQKVVGEKSYPKNGPTSPLFKVSGAKNFDEERKKLIGYIQKTQQMGRESFDGKENHSFGKLTAQEWNNMFVKHLNHHLEQFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S7</accession>
    <name>C6X0S7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806325.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01594"/>
    <dbReference type="EnsemblBacteria" id="ACU08040">
        <property type="protein sequence ID" value="ACU08040"/>
        <property type="gene ID" value="FIC_01594"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01594"/>
    <dbReference type="eggNOG" id="ENOG5033HH9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153126_0_0_10"/>
    <dbReference type="OMA" id="AYIPMAW"/>
    <dbReference type="OrthoDB" id="1754298at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="139" mass="14962" checksum="F87DF53C8C4219D6" modified="2009-09-22" version="1">MLRKVLAVIAGLVATGLVVGLVQMLGRYLYPMAPGSDPNDIEAVKEYVENAPFMALFFVIISYAAGALTGGFTATKIANDSSRAPAFIIGAIFALISVYMMLTIPSPFWFWILGIAAWGLVMVGRTLARRTSTLTVKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Z5</accession>
    <name>C6X0Z5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase chain E</fullName>
            <ecNumber evidence="7">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806393.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01664"/>
    <dbReference type="EnsemblBacteria" id="ACU08108">
        <property type="protein sequence ID" value="ACU08108"/>
        <property type="gene ID" value="FIC_01664"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01664"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_0_10"/>
    <dbReference type="OMA" id="VGKFHVQ"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="18844" checksum="2A74AFD715A51C5E" modified="2009-09-22" version="1">MSETIAFQPETLKQVQKIIGRYPEGKQKSALIPVLHLAQKEFGGWLDVPVMDYVADVLSIKPIEVYEVATFYTMFNMKPVGKYVLEVCQTGPCMLSGSDGILQHIRETLNIKNGETTADGLFTLKQAECLGACGYAPMMQLGKFYHEHLTNEKVDEILQLCRQGAIALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X121</accession>
    <name>C6X121_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806419.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01691"/>
    <dbReference type="EnsemblBacteria" id="ACU08134">
        <property type="protein sequence ID" value="ACU08134"/>
        <property type="gene ID" value="FIC_01691"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01691"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_10"/>
    <dbReference type="OMA" id="DFRWAFV"/>
    <dbReference type="OrthoDB" id="1558246at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="468" mass="51751" checksum="DB7EA2600B79201B" modified="2009-09-22" version="1">MPNQSPTFSSSTKKMLPFILATAIFMQMLDSTILNTSLPSIARDLNESPLDMQTAIISYVLTLALFMPVSGFLADKFGTRRVFIFSIVVFSLGSLFCAMSQDLTQLVISRVVQGIGGSLMTPVGRLALLKTYDKNELVRAMNYAIIPALIGPVLGPLVGGYMVDYLSWHWIFLINLPIGIVGIVMSLKHMPDYRSDTIKFDFKGFIIFASASLLLSVALESFGNTSHTTFVLLVFTLGFVMIYYYYKHAKKAENPIFPLNLFQVRTFRVGILGNLATRLGISSIPLLLPLMIQIAYGESAVISGWIVAPMALTAMFGKSFVLKVLNRFGYRRTLMGNTFIIGLLICCLGIPGITSSIYWFIPIIAVLGFFNSIQFTAMNTISIADLRNSHTSSGNSLLAVNQQLAIGFGIAFGLIVLKIFEGNTELMHGNPHLAFRYTFFVVGILTVLSGFVFRRLHYKDGENMRSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X147</accession>
    <name>C6X147_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA large subunit methyltransferase F</fullName>
            <ecNumber evidence="2">2.1.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">23S rRNA mA1618 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">rRNA adenine N-6-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rlmF</name>
        <name evidence="3" type="ordered locus">FIC_01717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the adenine in position 1618 of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16497"/>
            <dbReference type="Rhea" id="RHEA-COMP:10229"/>
            <dbReference type="Rhea" id="RHEA-COMP:10231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.181"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. METTL16/RlmF family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.181" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806445.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01717"/>
    <dbReference type="EnsemblBacteria" id="ACU08160">
        <property type="protein sequence ID" value="ACU08160"/>
        <property type="gene ID" value="FIC_01717"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01717"/>
    <dbReference type="eggNOG" id="COG3129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027534_3_0_10"/>
    <dbReference type="OMA" id="HQGRYDF"/>
    <dbReference type="OrthoDB" id="1027015at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052907">
        <property type="term" value="F:23S rRNA (adenine(1618)-N(6))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01848">
        <property type="entry name" value="23SrRNA_methyltr_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016909">
        <property type="entry name" value="rRNA_lsu_MeTfrase_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="PTHR13393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029038">
        <property type="entry name" value="Mtase_YbiN_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="327" mass="36989" checksum="93322439E5451B0B" modified="2009-09-22" version="1">MSTAKNTEKTRLHLRNKNRERYDLDALKIAVPELEKHIKANKYGEESVDFANPEAVKLLNKALLSHYYGIKNWDFPAENLCPPIPGRADYLHYMADLLGQSNFGTIPTGAKITALDIGVGASCIYPIIGATEYGWNFIGSDIDEQSVDSAQKIVEANEALSGKIEIRLQKNPEAFFKNIISPDDKIDLTVCNPPFHSSAEDAHKGSLRKIKNLSGKKTETAELNFAGISNELIYDGGEIGFIRNMILESKDFAQNCYWFSTLVSKESNMKKIYKMLEEVKTMHLKTIPMGTGNKSSRIIAWTFLSKEEQREWRETRWRLSEDKKTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X180</accession>
    <name>C6X180_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty acid desaturase</fullName>
            <ecNumber evidence="9">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806478.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01750"/>
    <dbReference type="EnsemblBacteria" id="ACU08193">
        <property type="protein sequence ID" value="ACU08193"/>
        <property type="gene ID" value="FIC_01750"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01750"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096051_0_0_10"/>
    <dbReference type="OMA" id="GVMHRMH"/>
    <dbReference type="OrthoDB" id="797871at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="29949" checksum="685FF954B359C820" modified="2009-09-22" version="1">MTIIIFIIVLWYSGLFFQTFFLHRYAAHQTYKMSRFGEKLCYFLTWVTQGSNYLSAYGYGVMHRMHHAYADTEKDPHSPKYDHNLFTMMWRTKSIYQQINQQKVKIEEKFTKNVPQWESFDKFASSWGSRIGWAVAYTLFFYFFATAWWQWILLPVAYMMAPIHGVIINWFGHIYGYVNFKVSDTSKNLFRFDWLMMGEAYHNNHHKFGGRANFGGVRWHEIDVTYQIMILLDKMKLIKLKPVPAVTREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X187</accession>
    <name>C6X187_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806485.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01757"/>
    <dbReference type="EnsemblBacteria" id="ACU08200">
        <property type="protein sequence ID" value="ACU08200"/>
        <property type="gene ID" value="FIC_01757"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01757"/>
    <dbReference type="eggNOG" id="COG3021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052333_0_0_10"/>
    <dbReference type="OMA" id="ENLYGMH"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="103"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="359" mass="41674" checksum="51CBB28DBD96143D" modified="2009-09-22" version="1">MDLVLIIFSLLLIVMSVLPFVKNQHWVFRVPEFMKVQLLVLQGLSLALNIFLLEKNLWFWVINGVQVVLVAYHFYILIRYTKFYRKKVASHNGNAQTIKVISANIYQFNSKYEKFHQLIRNYSPDVFITFESNAAWEEANRTLEKEYPHTQKMTLENTYGMHLYSKIPFDSAQFHFFVAEDIPSVEVHFTTSEGHKFVLFGVHPPPPSPTEERTSKERDGDLLALAKRIKAMDLPSLVIGDFNTVAWSDTSILFRKTSELIDARVGRGILATFHAKYWFFRVPLDLLFHSPDIMIEKLQTLEDIGSDHFPIYCAFYLNPSDPTQEDEVKTLDEDEGEEVDELIEEGKNEVTDNRSGHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X190</accession>
    <name>C6X190_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806488.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01760"/>
    <dbReference type="EnsemblBacteria" id="ACU08203">
        <property type="protein sequence ID" value="ACU08203"/>
        <property type="gene ID" value="FIC_01760"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01760"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099447_0_0_10"/>
    <dbReference type="OMA" id="VDRTTMT"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="21582" checksum="22481A35E0584596" modified="2009-09-22" version="1">MKKIIGKLILKLIGWKVVLEGDVNNLDRCVLVVAPHTSNQEYLLGNLAYWSLDKPLKIIIKDEHTKAWYGAVVKALGGVGIDRSQKNDLVKFVVDQFAKEDFSLVITPEGTRKRVAKWRKGFYHMAIAAKVPIVVAAGDFRTKQIHLGYKISVEDLETRTFESIMNEMEEYYKKITPKFPENWNPKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C0</accession>
    <name>C6X1C0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gliding motility protein GldC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806518.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01790"/>
    <dbReference type="EnsemblBacteria" id="ACU08233">
        <property type="protein sequence ID" value="ACU08233"/>
        <property type="gene ID" value="FIC_01790"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01790"/>
    <dbReference type="eggNOG" id="ENOG503176X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170347_0_0_10"/>
    <dbReference type="OMA" id="LWTKDMP"/>
    <dbReference type="OrthoDB" id="1715640at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019854">
        <property type="entry name" value="Motility-assoc_prot_GldC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19937">
        <property type="entry name" value="GldC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03515">
        <property type="entry name" value="GldC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="108" mass="12475" checksum="2D66A1FF4FEA4506" modified="2009-09-22" version="1">MRKTQITIDVELDENHIPERMLWNAQDGGIEAQETKATMISVWDDKNMEALRIDLWTKDMPVDQMKMFLHQILVSLSSTYQRATGEDDVAAWIEQMAEEFAAKSAIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L5</accession>
    <name>C6X1L5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hexuronate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806613.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01885"/>
    <dbReference type="EnsemblBacteria" id="ACU08328">
        <property type="protein sequence ID" value="ACU08328"/>
        <property type="gene ID" value="FIC_01885"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01885"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_1_10"/>
    <dbReference type="OMA" id="CINVLTY"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="512" mass="56900" checksum="97D14FAA70CE38AC" modified="2009-09-22" version="1">MAQNTETKATNFRWSICVLLFFATTINYLDRQVLSLTWKDYLQPEFHWDNNDYGNITALFSIFYAGSMLMAGKFIDWMDTKKGFLWAIFIWSIGAILHAFCGIATSGLLTGRWFVGFAEAKEAIATVNNVSLVISTSVTLFIFARLVLAIGEAGNFPAAIKTTAEYFPKKDRAFATSIFNAGATVGALAAPVSIPFIAKALGWEMAFIIIGALGFVWMGFWIFYYKKPHLHKKVNASELAYIQQDIDGEPIRLNAAGEDIGKKFTLKECFKYRQTWAFAFGKFMTDGVWWFYLFWTPAYLSSVYGMDSTESALPLFVLYIITLLAIIGGWLPKYFVDKLGLNPYAGRMRAMLIFAFFPLLALLAQPGGNYSYWIPVIIIGIAGAAHQAWSANIFSTVGDMFPKKAIATVTGIGGMAGGIGSFLINKSSGALFDFSHKNWTTVDAVPLLEKYPKFNTERIPDEFFNQLKASGAVISDGINTGYMIIFSVCAVAYLIAWVVMKALVPTYKVIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V9</accession>
    <name>C6X1V9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806707.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01980"/>
    <dbReference type="EnsemblBacteria" id="ACU08422">
        <property type="protein sequence ID" value="ACU08422"/>
        <property type="gene ID" value="FIC_01980"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01980"/>
    <dbReference type="eggNOG" id="ENOG5033RHY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650126_0_0_10"/>
    <dbReference type="OMA" id="AHIQNIF"/>
    <dbReference type="OrthoDB" id="845684at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021280">
        <property type="entry name" value="DUF2723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11028">
        <property type="entry name" value="DUF2723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="422" mass="48135" checksum="248D625A5D628C9C" modified="2009-09-22" version="1">MRKLKNPVSIFLIFLLIYSLGSFSKIPFGDCMALVLDTELGVYIKAATPTSHFLYSNAAIFIKNITNLDAILVSRYLVIVAGAFVVMMVYRTTQIITNKNWVSIAAAFVFGFSFTFWRNAEIVEVYTFNMVWVSLLLHYLIKVFLVEKNRETNMVLAAFFLSVSVWAHIQNIFFIPSVLLMLFYFKNYSRAALISLLLPIVSFAVMMGLNSSQNLSVTSIFKSGESTWVADSFKKDLFTYFKDFIKAFGYLLYNFNVFTIAGIFGIIALWRVNQKLFYTVSVAAVVIYGFATFYAVSDNYVFFLPFNYIFALSVGLGVASLKKQKLLARLSPLCLLIPFVYVSAFAISSKIPAAKNFNDSKAYKGGLRYYLVPWMHENVGILEFTIEKRNAPEPLYWMIDSAENYIEILKRKGLSREEIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z2</accession>
    <name>C6X1Z2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ordered locus">FIC_02013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806739.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02013"/>
    <dbReference type="EnsemblBacteria" id="ACU08455">
        <property type="protein sequence ID" value="ACU08455"/>
        <property type="gene ID" value="FIC_02013"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02013"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_1_10"/>
    <dbReference type="OMA" id="AHAISPI"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="62" mass="7059" checksum="1AD2F454F265DC1E" modified="2009-09-22" version="1">MKKADIKNLSAGDIQNKLAEVKADFNKLKLSHSISPIENPILIRDMRKTIARLETELTLKQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D2</accession>
    <name>TRMN6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA1(Val) (adenine(37)-N6)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.223</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA m6A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">FIC_02159</name>
    </gene>
    <organism>
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43160"/>
            <dbReference type="Rhea" id="RHEA-COMP:10369"/>
            <dbReference type="Rhea" id="RHEA-COMP:10370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.223"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.223" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806879.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6X2D2"/>
    <dbReference type="SMR" id="C6X2D2"/>
    <dbReference type="STRING" id="531844.FIC_02159"/>
    <dbReference type="EnsemblBacteria" id="ACU08595">
        <property type="protein sequence ID" value="ACU08595"/>
        <property type="gene ID" value="FIC_02159"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02159"/>
    <dbReference type="eggNOG" id="COG4123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061983_0_0_10"/>
    <dbReference type="OMA" id="NQYTEAF"/>
    <dbReference type="OrthoDB" id="1027015at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016430">
        <property type="term" value="F:tRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01872">
        <property type="entry name" value="tRNA_methyltr_YfiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022882">
        <property type="entry name" value="tRNA_adenine-N6_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000387379" description="tRNA1(Val) (adenine(37)-N6)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01872"/>
        </source>
    </evidence>
    <sequence length="231" mass="26032" checksum="F9DC5679B3A4077B" modified="2009-09-22" version="1">MKPFRFKKFTVQQHKEVFRVGTDGVLLGALADVSDAKNILEVGTGTGLVALMTAQRNPTSNITAIDVNPVAAELAAKNFLESHFGHRMRAMHCDYKTFGTQKKFDLIISNPPYFETNPSEKDATARQQRELSFKTLISKTAEILATEGRFCVIIPFPAGPTFEKTCEENKLFLLRRITVYGNANVEPKRLILEFSSNKNISVSEEIFVTEKAPRVYSEQYLKATADFHEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G6</accession>
    <name>C6X2G6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyanophycin synthetase</fullName>
            <ecNumber evidence="7">6.3.2.29</ecNumber>
            <ecNumber evidence="6">6.3.2.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cyanophycin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_02194</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13277"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.29"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23888"/>
            <dbReference type="Rhea" id="RHEA-COMP:13732"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.30"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.29" evidence="7"/>
    <dbReference type="EC" id="6.3.2.30" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806913.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02194"/>
    <dbReference type="EnsemblBacteria" id="ACU08629">
        <property type="protein sequence ID" value="ACU08629"/>
        <property type="gene ID" value="FIC_02194"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02194"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016806_0_0_10"/>
    <dbReference type="OMA" id="LAYDRCQ"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071161">
        <property type="term" value="F:cyanophycin synthetase activity (L-arginine-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071160">
        <property type="term" value="F:cyanophycin synthetase activity (L-aspartate-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009059">
        <property type="term" value="P:macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011810">
        <property type="entry name" value="Cya_phycin_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02068">
        <property type="entry name" value="cya_phycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="118"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="773" mass="83549" checksum="68A3DC65D2EF431F" modified="2009-09-22" version="1">MDNNLIRPAQATVADGLPGTEHDISAYHPEPQNNSTVVRNTHPEGTVLARHTTSEGLGPSTLSIIEEAERRGIPWRRMNDRSKILLGYGKNQQLIRATITGQTSCIGVETADDKFETKLLLGQAGIPVPKGVVCSSLEELRGAVEDLGFPLVLKPVDAHHGKGVTINITDLKTAEEAFAHAQNYGSEIILEKYIEGADHRMLVVNGKLVAATRRVPAHVIGDGKSTVSQLIEEVNQQPERGEGHEAALTKITVDCDTDRQLQKVNYTLESVPLQGETVFLKSTANLSTGGIGVDVTDEVHPENRFMAERIAALMGLDICGIDLIASDLKTPLAKNGGAVIEVNAAPGFRMHLEPSRGKSRNVAAAVVDMLFPPQSESRIPIFAVTGTNGKTTTTRILAHLVQSCGYFPGYTTTDGIYIGGHQIASGDCSGPSSASTVLADPMVDFAVLETARGGLLRAGLAFDYCDVAVLTNIAADHLGLKNINTLEELAEVKAAVVRSVKNTGWAILNAEDFHCNKIAEKLDCNIGFFSLDNSNAVIKKHIANGGLATTVEDGNLVIHQGKNRTFIAGIKDIPLTINGTSKCMTANILAATAAAFSYGFTPVQIHDALMSFVPGPELTPGRMNYFKVRDFSVLVDYAHNPHGLRAMQDYLTHIKAPRKVGIIAAVGDRRDSDIVELAEIAGNMFDHIIVRQEHSLRGRELSEMNKLMVQGIEKAGRAVKYDLIPDEKEAIRHALDTAQKDDYIVALSDNYQEVIEIINEFKQNNSTKAASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G9</accession>
    <name>C6X2G9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02197"/>
    <dbReference type="EnsemblBacteria" id="ACU08632">
        <property type="protein sequence ID" value="ACU08632"/>
        <property type="gene ID" value="FIC_02197"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02197"/>
    <dbReference type="eggNOG" id="ENOG502ZCHF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820737_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973498" evidence="1">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="338" mass="37553" checksum="80F833E0DA752126" modified="2009-09-22" version="1">MCMNKLILFISFLLYSACWSQVTLNPHNTGFLPVSSYSGATINNLINVRIHLNDSNGTQMKQWSLTYRVVGSITNGTENFPVEKLNFRFNSLDATAPFPNGNNAPTAQNLRLITGPLPFTTIESFFVQNSPYNLEVNGYAYLNLKYDVTAEGGAYLEKYKSWANYKVNLIVEIRNRKNEIMHSQPVSFDMQVYPNDSPPQTPTYGLQFDPSAKTVLLEFKTASDYANGVTKTQTKAFSTFSNTPYVIRVNTLTGNLTSTTNKTLPVSAVQLSVRDNQTQTVKGTVSLSSAQQNIITSTAHSANKFFDTVYSTQAGDTTFLNKSSEQYSGTLVFTMIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2I2</accession>
    <name>C6X2I2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN-binding negative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806929.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02210"/>
    <dbReference type="EnsemblBacteria" id="ACU08645">
        <property type="protein sequence ID" value="ACU08645"/>
        <property type="gene ID" value="FIC_02210"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02210"/>
    <dbReference type="eggNOG" id="COG2808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065853_3_0_10"/>
    <dbReference type="OMA" id="ARANPQW"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PTHR35802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="204" mass="23752" checksum="5D4EB17C189BA0A9" modified="2009-09-22" version="1">MYIPKIYKSEDRQLMKEIITQNAFALLISNKEKLWATHSMFILNESDQDFYLETHVSRGNLQAQVLEDGDEVLCDFLGANSYISSSWYDHLNVSTWNYEAVQVRGTIKLMTDDELYDHLRKLTLKFEQKQKCPVFAETIGEENIRNEMKGAFGINIFPTEIQIASKLSQNREEADFQNIIKELQQSPEENSRKIAEKMKISRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2I8</accession>
    <name>C6X2I8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-CoA oxygenase, PaaH subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806935.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02216"/>
    <dbReference type="EnsemblBacteria" id="ACU08651">
        <property type="protein sequence ID" value="ACU08651"/>
        <property type="gene ID" value="FIC_02216"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02216"/>
    <dbReference type="eggNOG" id="COG3460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141459_2_0_10"/>
    <dbReference type="OMA" id="PYRHPTF"/>
    <dbReference type="OrthoDB" id="2083684at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009359">
        <property type="entry name" value="PaaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038693">
        <property type="entry name" value="PaaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06243">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030200">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02157">
        <property type="entry name" value="PA_CoA_Oxy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="93" mass="10642" checksum="659F891B679E7D46" modified="2009-09-22" version="1">MSNLEMWEVFIQTKPGLSHKHAGTVQAATAEMALQSARDVYTRRMEGTSIWVVPSKYMVTSEGVDKEAFFDPADDKLYRHPTFYQIPNDVKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J5</accession>
    <name>C6X2J5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetic acid degradation protein paaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806942.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02223"/>
    <dbReference type="EnsemblBacteria" id="ACU08658">
        <property type="protein sequence ID" value="ACU08658"/>
        <property type="gene ID" value="FIC_02223"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02223"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_11_2_10"/>
    <dbReference type="OMA" id="FACNSHN"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="48"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="137" mass="15193" checksum="F3C793FB7AA7CAED" modified="2009-09-22" version="1">MSPHELAQYILSQDHFSQWMGIKLIEVREKYCLIEMPVKQEMINGLRTVHGGVTFSLADSALAFSSNNTNDASVALHCAMNFAKAVKLGDTLTAESILISDTRKTGVYDISITNQHKVLVASFRGTVYKIDKKVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K2</accession>
    <name>C6X2K2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02230"/>
    <dbReference type="EnsemblBacteria" id="ACU08665">
        <property type="protein sequence ID" value="ACU08665"/>
        <property type="gene ID" value="FIC_02230"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02230"/>
    <dbReference type="HOGENOM" id="CLU_2600899_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="79" mass="9120" checksum="2F41120B348C12C8" modified="2009-09-22" version="1">MNMFVFLTFCCTFLTNPHADFQQIYHIGVLGSGNLMYCRTHCRTNAVRTNAVNHMVHIFFFQARICAVITRRDAGSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K3</accession>
    <name>C6X2K3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B12 binding domain / kinase domain / Methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="2">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02231"/>
    <dbReference type="EnsemblBacteria" id="ACU08666">
        <property type="protein sequence ID" value="ACU08666"/>
        <property type="gene ID" value="FIC_02231"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02231"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_2_0_10"/>
    <dbReference type="OMA" id="LAMFMNT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="300"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="869" mass="98245" checksum="161A0E536832A7F4" modified="2009-09-22" version="1">MNSIDDARVYMRSMATRENNVSVSPHIHSALNILKIAKPDVIVLETSGIGQSGSEITDIADVSMYVMTPEYGASTQLEKIDMLDYADLIALNKSDKRGALDALQAVKKQYQRNHVLFEQPLEEMPVYSTKASQFNDWGTTELYNELIKKVNARFEGLNLSEYEEQNVSEETTIIPPKRVRYLSEIVETNRNYDKEVENQALIAKKMYLVEGAKALIQDDQHTHDKLEKVFLKTKKELSEENAAFLHGWHHFKEELEADTYSYFVRGKEIKVQTKSETLSHLKIPKIALPKFQDWGDLIRWKGQENVPGAFPFTAGIYPFKRTGEDPTRMFAGEGGPERTNRRFHYVSAEMDAKRLSTAFDSVTLYGQDPAFPPDIYGKIGNAGVSIATLDDAKKLYSGFDLVNAMTSVSMTINGPAPMLLAFFMNAAIDQNCEKYIEENNLWDKVEAKLKEKFDDKGLTRPTYSGELPPSNNGLGLKLLGLTGDEIIETDAYAKIKAETIATVRGTVQADILKEDQAQNTCIFSTEFALRLMGDVQQYFIDEKVRNFYSVSISGYHIAEAGANPISQLAFTLANGFTYVEYYLSRGMDINEFAPNLSFFFSNGIDPEYAVIGRVARRIWAKAMREKYNANERSQMLKYHIQTSGRSLHAQEIDFNDIRTSLQALYAIYDNCNSLHTNAYDEAITTPTEESVRRAMAIQLIINKELGLAKNENPLQGSFIIEELTDLVEEAVYAEFDRITERGGVLGAMETMYQRSKIQEESMHYEWLKHTGEYPIIGVNTFLGKDGSPTVLPGEVIRSTEEEKQLQIKNLENSQKANAHKTEDALKRLQHGAINQENLFALMMDAVKYCSLGQITNALFEVGGMYRRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N3</accession>
    <name>C6X2N3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5808 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806980.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02263"/>
    <dbReference type="EnsemblBacteria" id="ACU08696">
        <property type="protein sequence ID" value="ACU08696"/>
        <property type="gene ID" value="FIC_02263"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02263"/>
    <dbReference type="eggNOG" id="ENOG5033JGC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203837_0_0_10"/>
    <dbReference type="OrthoDB" id="2082765at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043831">
        <property type="entry name" value="DUF5808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19124">
        <property type="entry name" value="DUF5808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5808" evidence="2">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="69" mass="8147" checksum="E7EEFE2AEB76B2D4" modified="2009-09-22" version="1">METNNYGNDGANWIWGVFYYNKSDKRIFPPKRIPWMGWTVNFANWKSILALVVVIAIFFGLMWFIVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q3</accession>
    <name>C6X2Q3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">clpB</name>
        <name evidence="12" type="ordered locus">FIC_02283</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807000.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02283"/>
    <dbReference type="EnsemblBacteria" id="ACU08716">
        <property type="protein sequence ID" value="ACU08716"/>
        <property type="gene ID" value="FIC_02283"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02283"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_10"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="410"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="863" mass="97620" checksum="B60E8B7AFC269A77" modified="2009-09-22" version="1">MNLNQYTVKSQEAIQKAQQIAMEFGNQIIEPQHLLEGILQVDENISAFLMKKSEAELSLVRDRNRENLEKLPKVEGANIYLSQTSNKVLLDAPNIAKKMGDEYVTIEHLWLSLLEVGSDVSKMLKDMGVTRKGLELAINELRKGSKATSASSEETYQSLNKYAKNFNILAAEGKLDPVIGRDEEIRRVLQILSRRTKNNPILIGEPGVGKTAIAEGIAHRIISGDIPENLMDKTLYSLDMGALIAGAKYKGEFEERLKSVINEVIKSDGQIILFIDEIHTLVGAGGGEGAMDAANILKPALARGELRAIGATTLSEYQKYFEKDKALERRFQKVMVEEPDSESAISILRGIKDKYEAHHKVRIKDEAIIAAVEQSQRYISDRFLPDKAIDLIDEASAKLRMEINSKPEELDVLDRKLMQMEIELAAISRESNDIKINHLKEDISRISEERNEINAKWLKEKQKSEDLTSIKKDIEALKLEAERASRIGDYAKVAEIQYGKIKEKESDLEKLELEMQNNQNELIKEEVTAENISEVISKWTGIPVTKLLQSEREKLLHLEDELHKRVVGQDEAIESIADAIRRNRAGLNDEKKPIGSFLFLGTTGVGKTELAKALAEYLFDDENNMTRIDMSEYQERHSVSRLVGAPPGYVGYDEGGQLTEAVRRRPYSVVLLDEIEKAHPDVFNTLLQVLDDGRLTDNKGRVVNFKNSIIIMTSNLGSHLIQENFENITDDNVTEVVAKTKEEVFALLRQTLRPEFLNRIDETVLFQPLNRKEIGKIVHYQLRGFNKMLERRGIFMTATEDAVDYIMNKGYDPSFGARPLKRVLQQEVLNKLSKELLAGKINDGDRITLDYFDESGLVFRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q6</accession>
    <name>C6X2Q6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-CoA oxygenase, PaaG subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807003.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02286"/>
    <dbReference type="EnsemblBacteria" id="ACU08719">
        <property type="protein sequence ID" value="ACU08719"/>
        <property type="gene ID" value="FIC_02286"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02286"/>
    <dbReference type="eggNOG" id="COG3396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879733_0_0_10"/>
    <dbReference type="OMA" id="MQPEANW"/>
    <dbReference type="OrthoDB" id="623539at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097266">
        <property type="term" value="F:phenylacetyl-CoA 1,2-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011881">
        <property type="entry name" value="PaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02156">
        <property type="entry name" value="PA_CoA_Oxy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="310" mass="35564" checksum="05710E3D82883E05" modified="2009-09-22" version="1">MNHEKFLAYVQAENKVEPKDVMPDDYRKLLVRQISQHAHSEIVGMLPEANWITRAPSLRRKMALLAKIQDEAGHGLYLYAAAETLNNGEIAADRDSTYNDMLSGKAKYSSIFNYPALSWADIGAIGWLVDGAAIMNQVMLMGNSYGPYSRAMVRICKEESFHQRQGYEILMTLCRGTKEQKELAQEALNRFWWPALMMFGPNDEASPNSQKSMNYRVKRESNDALRQRFVDVTVEQAEFLGLKIPDENLKWNEETQHYDFGELPWGEFMEVLKGNGPCNKKRLETKRKAQREHAWVKEAAMAYANNNVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R6</accession>
    <name>C6X2R6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807013.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02296"/>
    <dbReference type="EnsemblBacteria" id="ACU08729">
        <property type="protein sequence ID" value="ACU08729"/>
        <property type="gene ID" value="FIC_02296"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02296"/>
    <dbReference type="eggNOG" id="ENOG5033GY6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545343_0_0_10"/>
    <dbReference type="OMA" id="CKKEANV"/>
    <dbReference type="OrthoDB" id="1427233at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="173" mass="18733" checksum="5C049CA4F337064C" modified="2009-09-22" version="1">MKKLIVVFAVFIISCSKKQNVCENAAGSDSIISSDANLSEDSLSDSGKINSDPESSASITGNSRSAENGQTTTTINAEMLPLTLNEEFTDKQQSYIIKIENFSGESISGEIVPENPQMNIRFNQIRLPDGTLDGPFSREISYKTPDKGEIWLIVGKSNMASGVSTGKFTVKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S0</accession>
    <name>C6X2S0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807017.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02300"/>
    <dbReference type="EnsemblBacteria" id="ACU08733">
        <property type="protein sequence ID" value="ACU08733"/>
        <property type="gene ID" value="FIC_02300"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02300"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459148_0_0_10"/>
    <dbReference type="OMA" id="MNVWGSG"/>
    <dbReference type="OrthoDB" id="87662at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="533" mass="60586" checksum="EFF62464EBD4074C" modified="2009-09-22" version="1">MDKKELRSSIFRHLDGIVTAPVVAALHKKGIVAALEKHQRIELKDLLKEFPANEGYLNVALRVLASQGFVNYELDNAQDTVVVRANAKTRYLLWAAHLYENVIPYLKESVGFEFQNLEPAAFNNLIALFDEFKKSFGLQESTDAEELKVQNQILKHIEGCLVGPIIVHLGMSGMFHKYFMETSFQAVEFHKDPENFEKILDFLTDLGWFTRNNKNFKFTENGLYFARRAASYGVTVSYLPTLNRMEDLLFGNATKLRDISEKEDEIHVNRKMNVWGSGGAHSTYFKVVTDFIIAIFNQPIHLQPKGILDMGCGNGAFIQHIFETIERHTLRGKMLEDYPLFLVGADYNQAALNVTRANLINNNIWAKVIWGDIGNPDLLAKDLLENYDINLGDLVNIRTFLDHNRIWRNPSNMNPDRVSTSTGAFAFRGDRIPNHLVEENLKEHLSLWLPYIKKNGLLVIELHTLSPDLTSQHLGETAATAYDATHGFSDQYIVELEVFHKICKEVGLAVDQDLFKKYPASDLATVSINLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S2</accession>
    <name>C6X2S2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807019.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02302"/>
    <dbReference type="EnsemblBacteria" id="ACU08735">
        <property type="protein sequence ID" value="ACU08735"/>
        <property type="gene ID" value="FIC_02302"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02302"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105077_1_2_10"/>
    <dbReference type="OMA" id="YIEHLAI"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="20426" checksum="1D468C3F9AC44957" modified="2009-09-22" version="1">MEYLQVPSFDDFRAQEIYRSYCETFPEDERRSEKQFRELFKNPKVKVLSVLENLQNIGYLVTWELTGFVFVEHFEIFSQYRSLKYGSQIISDLFKNYLHIVLEAEPANLGDDAKRRIAFYDRNGFGIIDENYVQPCYDPEKQALNLWLLANWQPEKTDWIKEEIYDVVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X4</accession>
    <name>C6X2X4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative auxin-regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807071.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02354"/>
    <dbReference type="EnsemblBacteria" id="ACU08787">
        <property type="protein sequence ID" value="ACU08787"/>
        <property type="gene ID" value="FIC_02354"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02354"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016249_4_0_10"/>
    <dbReference type="OMA" id="TNCIEDW"/>
    <dbReference type="OrthoDB" id="566369at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="501" mass="57575" checksum="0D090FC035B799E9" modified="2009-09-22" version="1">MLNFLKKKIALIWAKKHVKATETFKNNAVEDQQKLLLSLVKTAEKTLFGRERNFENINSVHDFQKNVQIADYEDLKPYIEKVKKGQRNILWTETPEYFAKTSGTTSGSKYIPISKEGMPYQLAAAQSAIFHYISQKNNSSFVAGKMIFLQGSPELEEINGIKTGRLSGIVAHHIPNYLQKNRLPSEKTNLIEDWETKVDEIVKETEKENMTLISGIPPWLIMYFEKLIERNGKKITELFPNLQLIITGGVNFEPYREKMNELLGKPVDIIQTFPASEGFFAFQDDYTKEGLLLLTNHGIFYEFIPLETYGKPDAKRLTLKDIELHRDYALILTTNSGLWAYSIGDVVRFISIDPYRVVVSGRTKHFTSAFGEHVIAFEVEESMKATVEKFPAQITEFHLAPQVNPAEGLPYHEWFIEFEKEPEDLEQFRKNLDEEMRKRNTYYDDLISGNILQPLIINSLPRNAFQEYAKSEGKLGGQNKIPRLANDRKIGDFLSKLAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X307</accession>
    <name>C6X307_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807104.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02387"/>
    <dbReference type="EnsemblBacteria" id="ACU08820">
        <property type="protein sequence ID" value="ACU08820"/>
        <property type="gene ID" value="FIC_02387"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02387"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1861647_0_0_10"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973407" description="TonB_C domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="2">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="13809" checksum="336E8A667EF3995D" modified="2009-09-22" version="1">MKKLLLLFGLILSSLTFAQAISEDSAVVTEKIADFPDGGAQNFRQLLAKNFRSKKVKGSGKVSCQLKFVVERDGSITNVTVIGSNESFNKEAVRAISLIKTKWEPAKINGVPVRYRFTVPLTMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X333</accession>
    <name>C6X333_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807130.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02413"/>
    <dbReference type="EnsemblBacteria" id="ACU08846">
        <property type="protein sequence ID" value="ACU08846"/>
        <property type="gene ID" value="FIC_02413"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02413"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042661_1_0_10"/>
    <dbReference type="OMA" id="TYLWFSQ"/>
    <dbReference type="OrthoDB" id="1778971at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="443" mass="50630" checksum="D700925DD68D1546" modified="2009-09-22" version="1">MYSFSPKLRLYSIILIALGIVLFGVGYFMNHGIDDARIEHMMEAVHAGGDHVPTHSSEMVGPQDHEAHLDHAKLQVHNQPLAAIHIVAVFLFALSCCALFFYCIQNAAHAGWSIIILRVMEAIASFIPWAGGILIILMILNITHQGHLFHWMDPELTTPGDPHFDSILYEKKTFLNIPFYAIRTILYVVGASFFVWKLKSLSKKVDETKSRADYATYYNWSIGYIAFFGFASAGWAWDWLMSIDPHWYSTMYIWYAMVSCLASAIAAIILISVYLKKKGVLPQFNDNHLHDLGVFLFASSMLWTYTWFCQFMLYWYANVPEEVNYFFGRFKYYSPTFLPMLILNFLIPLLVLVSSSIKRNYTVVTTVAVIVLVGHWLDYFNMVMPGTVGPYWKTPEVLLLNLGSVLFGVGLFVFVVLTALSKLKLIPEGNPYVKESKIYEYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X356</accession>
    <name>C6X356_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">psd</name>
        <name evidence="7" type="ordered locus">FIC_02436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="5">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807153.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02436"/>
    <dbReference type="EnsemblBacteria" id="ACU08869">
        <property type="protein sequence ID" value="ACU08869"/>
        <property type="gene ID" value="FIC_02436"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02436"/>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072492_1_0_10"/>
    <dbReference type="OMA" id="VSIFMSP"/>
    <dbReference type="OrthoDB" id="891720at2"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023329942" description="Phosphatidylserine decarboxylase beta chain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023329941" description="Phosphatidylserine decarboxylase alpha chain" evidence="5">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="5">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="217" mass="24728" checksum="74F7DCAC139F78E6" modified="2009-09-22" version="1">MKLHKESTGTIVVASVIFAVAAIVSVYYLEQWSLLILIPMLVIFGLIFWFFRVPNRDIQDHKENVIAPVDGKVVMIKEVDENEFLNEKAIQISIFMSPLNVHICRFPVSGKVIYKKYHPGRYLVAWHEKSSTENERTTIAVESLTNHKVVFRQIAGYVARRIVFYCNEGDDAKAGHEFGFIKFGSRMDIFLPLDTEITCKIGDKTKGGIDVIAKMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X377</accession>
    <name>C6X377_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807174.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02457"/>
    <dbReference type="EnsemblBacteria" id="ACU08890">
        <property type="protein sequence ID" value="ACU08890"/>
        <property type="gene ID" value="FIC_02457"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02457"/>
    <dbReference type="eggNOG" id="ENOG50339UG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2206162_0_0_10"/>
    <dbReference type="OrthoDB" id="2099757at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="107" mass="11402" checksum="749C701B70CE644C" modified="2009-09-22" version="1">MKNIGIMAVFVLFTACSQTETKTETIENADGTTSVKTIETEKTSALDSATVHATVQNAKEKLNEAGETLNEAGKDIKVATKKGAAKVEKGAEKIEADLSTKKRDTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X378</accession>
    <name>C6X378_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative auxin-regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02458"/>
    <dbReference type="EnsemblBacteria" id="ACU08891">
        <property type="protein sequence ID" value="ACU08891"/>
        <property type="gene ID" value="FIC_02458"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02458"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016249_4_0_10"/>
    <dbReference type="OMA" id="EGFFAIQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="507" mass="58140" checksum="24720325D2A5F1FD" modified="2009-09-22" version="1">MSQMATKALFNTVVNWFIRQRIDQIENFIRQPIETQHGVLFSQLYHAENTDYGKIHGFSSISTYEDFRRNVPVVTYEDFEPFIEKARQGKADVFWPGYIRKFAKSSGTTNAKSKFIPISEESLEDCHYKAGKDLLSIYANNHPENSLFSNKNLRLGGSAELYQDFNTKFGDLSAIMIENLPFWVEITTTPSKKVSLMSEWESKLKAIVSEVKNEDVGSITGVPSWMMVLLQRTLQETGHATISELWPNLEVFFHGGISFKPYREQYNKIIGKEINYYEIYNASEGFFAIQDRHGSDEMLLMLDYGIFYEFIPMDTFHSAGRQAIPLSEVELGKNYAMVITTNSGLWRYLIGDTVKFTSLSPFRIRVSGRTKHYINAFGEELMIDNVEAALTRACAETNACVSDFTGAPVFMKDGDSGAHEWIFEFTQNPDDLERFTDIFDEALKSLNSDYEAKRYNNMTLNRPVVHVAKPQLFYNWMSSRGKLGGQNKVPRLSNDREYIDPILEMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X392</accession>
    <name>C6X392_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807189.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02472"/>
    <dbReference type="EnsemblBacteria" id="ACU08905">
        <property type="protein sequence ID" value="ACU08905"/>
        <property type="gene ID" value="FIC_02472"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02472"/>
    <dbReference type="eggNOG" id="ENOG5031GJP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2071341_0_0_10"/>
    <dbReference type="OMA" id="TSSHMMD"/>
    <dbReference type="OrthoDB" id="1814073at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045755">
        <property type="entry name" value="FtsL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19579">
        <property type="entry name" value="FtsL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="14243" checksum="7587F3C21216C6D8" modified="2009-09-22" version="1">MAKKPTYRTQKKLTFIDIVKGNFLNRDEVKIHYRYFLLVFVLLMIMIYSNHLVSQKIELVNDLKEQTEEYKSRNAYAQSRLIKVKLESELGKEMVEDSLLSLENHPHKLLIKLDSTDGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X399</accession>
    <name>C6X399_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807196.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02479"/>
    <dbReference type="EnsemblBacteria" id="ACU08912">
        <property type="protein sequence ID" value="ACU08912"/>
        <property type="gene ID" value="FIC_02479"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02479"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_0_0_10"/>
    <dbReference type="OMA" id="GNTDCYQ"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="53"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="346" mass="39781" checksum="5EEDBE46557372BC" modified="2009-09-22" version="1">MEQNFIKGQGAQRNEINRFDRYTFEPEPEDADFFKTTFTEVFPKTIVNAVKSPDMMMEYSLNPYQGCEHGCSYCFARPTHEYWGYSAGTDFERKIMVKKNAPELLEKFFQKRNYVPKTISLSGNTDCYQPAEKKFEITRKLLQLCLEYRHPVSILTKNALVLRDLDVLKALAEQNLVSVSFSIPTINEEVRRKMEPRTSTAHNKIKAIEILTENKIPVGVMVAPVIPGLTSDESLSILKTISDAGARSFSYVIVRLNDTVEPVFVNWINASFPDRAQKVLNLIRSMRGGNLGEKRFYERYKGEGNIAELIHNTFALGRRKFFADREMPVLSTENFTGTKEHQLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A7</accession>
    <name>C6X3A7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase, aminase component</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02487"/>
    <dbReference type="EnsemblBacteria" id="ACU08920">
        <property type="protein sequence ID" value="ACU08920"/>
        <property type="gene ID" value="FIC_02487"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02487"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_1_0_10"/>
    <dbReference type="OMA" id="MKGTINA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="77"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="326" mass="37115" checksum="4D6BB219D9DDA253" modified="2009-09-22" version="1">MMFSAPHPNFDRMDELSMTKVPFFFMVDFLMENVEVYDEKQFLNSGLKTDFQSIASVKTPLKEHLGFHFKSIPEPAENYRRGFTLVQENLRAGNTYLANYTCRSEIETNLSLEEMYASAQAKYKVYYPEKFVFFSPETFVEIAGGRIFTHPMKGTIDAAAENAAEVLKADPKEKAEHYTVVDLLRNDLSIVADEVKVDEFQRIDLIKTNQKNLYAMSSEISGTLKPEFLGKVGSIMTALLPAGSILGAPKKKTLEIILEAENYHRGFYTGVCGWFDGENLDSCVMIRFIEKENGKLYFKSGGGITHLSKFADEYQEMKNKIYVPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I9</accession>
    <name>C6X3I9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807286.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02572"/>
    <dbReference type="EnsemblBacteria" id="ACU09002">
        <property type="protein sequence ID" value="ACU09002"/>
        <property type="gene ID" value="FIC_02572"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02572"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_10"/>
    <dbReference type="OMA" id="KMPERDY"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU09002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="247" mass="26152" checksum="28CCBC2D7FD9F631" modified="2009-09-22" version="1">MKLLEGKVALITGATRGIGKGIAEVFAREGAKVAFTYAGSVDKAKALEEELSKITTAKSYQSDASDYDAAQKLVEDVMAEFGKIDILINNAGITKDNLLMRMSKDDWDTIIKVNLDSVFNLTKAVIKPMMKAKSGSIINMTSVVGVKGNAGQANYAASKAGVIGFSKSVALELGSRNIRCNAIAPGFIETEMTAALDEKTVQGWREGIPLKRGGQPEDVANACVFLGSDMSGYITGQVLNVDGGMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K7</accession>
    <name>C6X3K7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782142.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00537"/>
    <dbReference type="EnsemblBacteria" id="ACU06995">
        <property type="protein sequence ID" value="ACU06995"/>
        <property type="gene ID" value="FIC_00537"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00537"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_2_10"/>
    <dbReference type="OMA" id="DHDINTA"/>
    <dbReference type="OrthoDB" id="2062716at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="16676" checksum="48883B06EA882218" modified="2009-09-22" version="1">MKILVVCLGNICRSPFAEGILKSVLPEDFEVDSAGTISLHEGEHPDKRAVQTAKNHGIDISKQRSRPITIEDFDVFDKILCMDLSIMEDVVSMAKTDGQRAKVSLFLQEAGIAGNNYEVFDPYWSEMDGFEEVFLLLKDASEKLKAKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q0</accession>
    <name>C6X3Q0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidyl-peptidase</fullName>
            <ecNumber evidence="4">3.4.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase S46 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782185.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00583"/>
    <dbReference type="MEROPS" id="S46.002"/>
    <dbReference type="EnsemblBacteria" id="ACU07038">
        <property type="protein sequence ID" value="ACU07038"/>
        <property type="gene ID" value="FIC_00583"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00583"/>
    <dbReference type="eggNOG" id="COG4717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013776_0_0_10"/>
    <dbReference type="OMA" id="KDWFFNP"/>
    <dbReference type="OrthoDB" id="99817at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070009">
        <property type="term" value="F:serine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019500">
        <property type="entry name" value="Pep_S46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38469">
        <property type="entry name" value="PTHR38469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10459">
        <property type="entry name" value="Peptidase_S46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="713" mass="80080" checksum="C0683DB76569562B" modified="2009-09-22" version="1">MKSKNILLAAIIFPAVMAFGQQYGGMWIPTELNEKEMKDLGMKISAKQIFDPSKPSIKDAVVQFNGGCTAEIISPQGLLLTNHHCGYGQIQKHSTVQNDYLSNGFWAKNMTGELANPGVTVDFIADIKEVTGQVLAGTQNIDPKAAQSIIDKNSEAVKAGFKLEPWQKVVIKPMYYGNKYYAYVIDTYKDVRLVGAPPQSIGKFGSDTDNWVWPRHTGDFAMFRIYADKDNKPAEYSKDNVPYKPKHYLPVSIKDKKENDFTFVFGFPGRTTEYLPAIAVEKVMTDTDPAMISVREVALKTLDEKMRADAETRIKYASKYASVANYWKKWIGEVEGLKKSDAVGKKKQYEQSLIAKNPQIKPTIDGLNNLYTEQAPFALNRAYYSEVVRNAETLTLANLYLNFMQSFEAGKADEKSQTAFKNRLAAFYKDYDAELDAKVTAKLLALYAAKTPQQFLPANFSQFNDETKNLATLENWSANSVITGRKAFNGATAAADIQKVFANPAELIKTLKTDPIIQLASSMRETYLTTTETRFASLQDQIDVLQKKYMAQQMETDKDRKFFPDANSTLRVTYGQVKGSSPRDAVSYGYQTHVAGIMEKYVPGDYEFDVPKKLVDLYNAKDYGIYKDKTGDVPVNFTATNHTTGGNSGSPALDADGNLIGLNFDRQWEGTMSDINYDPRFSRNIMVDTKYILFIIDKYADAKWLINEMKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S3</accession>
    <name>C6X3S3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782208.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07061">
        <property type="protein sequence ID" value="ACU07061"/>
        <property type="gene ID" value="FIC_00606"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00606"/>
    <dbReference type="eggNOG" id="ENOG50311GT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164502_0_0_10"/>
    <dbReference type="OrthoDB" id="1859758at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="238" mass="26072" checksum="BEB813BC3E795753" modified="2009-09-22" version="1">MANIKKNGNLSGAIGNIVFVNDGDRVFVRAKPDIVKQSQRTKDSAKEFGLVSSREKIFRLRVLHAMGIPALQYFAARHRARIRKTLTADNGSTAITNPTFGNPQALTGFSFNPKTEWQTCTNFFPEFDIQPGNEIKVLLPQLKWKEQIVPPKNSTSALLTLLALTADLNSASVPVNVQSELEIEINGSSPAPAQQWAFPAGSSAGWLLIIGCLKFKTQNKLEATKQFAATYLWAGLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T4</accession>
    <name>C6X3T4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07072">
        <property type="protein sequence ID" value="ACU07072"/>
        <property type="gene ID" value="FIC_00617"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00617"/>
    <dbReference type="eggNOG" id="ENOG5032U6J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1298255_0_0_10"/>
    <dbReference type="OrthoDB" id="1616167at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="212" mass="25094" checksum="0846753EC3274911" modified="2009-09-22" version="1">MEFIKRLFKTNKKPSDSWTMFSTSKSEVRELLVSTGQLTIGDDFLKIENYPFEPSIAYRQTIFKTNQIDDIDFKSYPPTFRVGNELIYLMSEIKVELEEFAKKNNIKTIERPMIWGWILEPFLDTEFTTETDQRLTKLLESYGLTTDQVKSLRTEVETQMLKYNFDTMLWEWGGFDALAVLKAMRTKYKKEEFGVFYRRVMEIALLTKKTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3U1</accession>
    <name>C6X3U1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782226.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00624"/>
    <dbReference type="EnsemblBacteria" id="ACU07079">
        <property type="protein sequence ID" value="ACU07079"/>
        <property type="gene ID" value="FIC_00624"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00624"/>
    <dbReference type="eggNOG" id="ENOG5032Y10">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370404_0_0_10"/>
    <dbReference type="OMA" id="WTGEYSE"/>
    <dbReference type="OrthoDB" id="1202995at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="199" mass="23560" checksum="97A2C21DD4E6913A" modified="2009-09-22" version="1">MKVTRQNLIELCDSFLENKIDKTAIQNFAWTAISDDDFEWDEDEIISDTIFEWDNEDINFEINRTNVSLWKKRLLTEKDDLLIHNNWNVHIEAQKEICEKCNSTWKPINKKLNIGVSTNLEKDPINGLRHPAEKGTTGWFIWTGEYSEANDFFQPICAEHLLQQRPEIIKYLGLDVGFRFLTDIKGYEDIWYDEKLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3U6</accession>
    <name>C6X3U6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782230.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00629"/>
    <dbReference type="EnsemblBacteria" id="ACU07084">
        <property type="protein sequence ID" value="ACU07084"/>
        <property type="gene ID" value="FIC_00629"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00629"/>
    <dbReference type="HOGENOM" id="CLU_1515741_0_0_10"/>
    <dbReference type="OMA" id="GKISEYF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="21067" checksum="A8FC1A03803BCFDA" modified="2009-09-22" version="1">MEFKEKNIQTIIDLSLGYFMITTVSVNTKISKSDQANIISEFLKTKYFVWNYENEPYGQNVIITDENGKISEYFNEKFFGFYETKKLEYSDFKDIAFESFESNIKNKVLQETNNDFLNNCLKILKNINSKSDFYILNPPKNKIPQFVKDFPIYTFFYSYLNFDEENCEIKLIEFGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X403</accession>
    <name>C6X403_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division trigger factor</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782287.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00686"/>
    <dbReference type="EnsemblBacteria" id="ACU07141">
        <property type="protein sequence ID" value="ACU07141"/>
        <property type="gene ID" value="FIC_00686"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00686"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045516_0_0_10"/>
    <dbReference type="OMA" id="FRKGMVP"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trigger_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="444" mass="50528" checksum="824123F68612BCE4" modified="2009-09-22" version="1">MNVTATNHDEVSALLTVTLDKSDYKEKVEKQLINYAKNAQVPGFRKGKVPLSMVRKQYESGIAFEEINKQVSEALNGYVQEKGLRLVGQPVPQPVDDLNLSSEQLSVAFEVGYEPEFSIDLSKYEAPHFKVEASDKEIGQSIENMQKRFAEQVPQEAIGDDSHIALEISQVVEENAEGAHNHPPKSIVVNADKKAAFALVKDLKMDGSVKVSKEELQNNEELATELGFNKEETAHLHHDQIEVKVKDFYGLNLAELNQELFDKVYGEGNITSEEELKAKVKTELDEYFQQNADVHFVNKILGQINEKEEVKLPEAFLIKWLMFSNENVKDENQAKEILEAERNQLKYQILEGKLMNDNEIKLEYSDVLNQAEQLVRNQLAIYGIHHLSDEEIQKYAVEMLKDQEQVRQISSEVGMAKLKDVILEKAKKVETAISHDEFLEEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C0</accession>
    <name>C6X4C0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782404.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00805"/>
    <dbReference type="EnsemblBacteria" id="ACU07258">
        <property type="protein sequence ID" value="ACU07258"/>
        <property type="gene ID" value="FIC_00805"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00805"/>
    <dbReference type="eggNOG" id="ENOG5033E03">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137842_0_0_10"/>
    <dbReference type="OMA" id="HWFYFGD"/>
    <dbReference type="OrthoDB" id="1944834at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="146" mass="17412" checksum="F519DF3CB861F960" modified="2009-09-22" version="1">MDKLLSLLLGVLFLQISCNSKLNQYREVSDSQRHRHGKWIEKDNVAGGEFLMKGKYKNGEKAGIWRTYYNGDLFQKDRIKDSIILTKIYFPDGKIKERGQSKLIITNDLRHWFYFGDWKYYNQNGELQYIKTYHPNNQFDSISFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D4</accession>
    <name>C6X4D4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00819"/>
    <dbReference type="EnsemblBacteria" id="ACU07272">
        <property type="protein sequence ID" value="ACU07272"/>
        <property type="gene ID" value="FIC_00819"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00819"/>
    <dbReference type="eggNOG" id="ENOG5032UBC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178557_0_0_10"/>
    <dbReference type="OMA" id="HATHEVQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972296" evidence="1">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="234" mass="24892" checksum="372E00143EA25840" modified="2009-09-22" version="1">MVMKNKFILLLCFVGAIVSAQVGINTTSPNATLDVNGNVMVRTVPPASVRPSYDFMVVNHATHEVQKISGNLVAPNVNTTMAKADATSGVSLINSSLFAGWQKIDFTGPIAIDPGTHFNSATDHYIVPSSGVYVVNYEFRYGDGISLSVANFSGTPKIGILRHTSTGYNVLDQKNFSSAGIPMVVNILISESSINSIYRLTAGDMLSFEVDDGGLALGLLSSSRASFSVYKISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E3</accession>
    <name>C6X4E3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ordered locus">FIC_00828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782427.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00828"/>
    <dbReference type="EnsemblBacteria" id="ACU07281">
        <property type="protein sequence ID" value="ACU07281"/>
        <property type="gene ID" value="FIC_00828"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00828"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_4_1_10"/>
    <dbReference type="OMA" id="EYDTYRM"/>
    <dbReference type="OrthoDB" id="1937493at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="179" mass="19878" checksum="CD3B970F23095D43" modified="2009-09-22" version="1">MLTSKVAKRYAQGLLNFTKESGSTDAVFTEMGDMVKTIRNSKELQNFFASPVIDSKKKISIALEIFKGFSPVTQSLVQLIIKQGRESQIQNIAQEFVNKVNEMNGVQRITLTSATQLTEGNIESVLKSTPLINHDNKFDVKTIIDPAILGGYILRVGDQQIDASVKSKLGKLKKEFQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N3</accession>
    <name>C6X4N3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_00920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00920"/>
    <dbReference type="EnsemblBacteria" id="ACU07371">
        <property type="protein sequence ID" value="ACU07371"/>
        <property type="gene ID" value="FIC_00920"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00920"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_4_1_10"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="144"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="260"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="385" mass="42980" checksum="C4395489969DC4BE" modified="2009-09-22" version="1">MTFKNKYIQMKFIVASGELQKALNTVSGVISSSQSRPILENYLFEIDENNLKITASDGETTLVTSLEVRSDDTGKFAVPAKIFQDFVKTYGEQPLTLSVKDAEDGNGSLLEILDEKDNFAVALDHAEDYPELPEFDASQSVKISAGILCEALTNTLFATSNDSLRPVMTGVLFQFKEDETNFVSTDSHRLVVYKRTDLMNAEPIEFIMPKKPLAIFKNILANSSDDVTIEFNENMAKFTFGNNIWICRLIDGKYPNYSAVIPKENPNVLTINRNLLLSSIRRASIMSNKSTNQVRFKLSGNILHLHAEDTEYANKADMQIPCDYNGEDINIGFSSKFLTEMLSVLSSDDITMKMSQPNRPGIIEPVDGLETDENILMLSMPVIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T1</accession>
    <name>C6X4T1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-hydroxybenzoate polyprenyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782565.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00968"/>
    <dbReference type="EnsemblBacteria" id="ACU07419">
        <property type="protein sequence ID" value="ACU07419"/>
        <property type="gene ID" value="FIC_00968"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00968"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073311_0_0_10"/>
    <dbReference type="OMA" id="WFYSHKL"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="34441" checksum="421D60A7193D32E3" modified="2009-09-22" version="1">MKNPLFYRISQLVGFLLGARIFIAVLLTFALYVSTFFLFNQEETLRDFVFDFKVHGIIFCTVLSILAGGIINQFYDREKDQLTKPFRSRLQSFLKLKYFLYAYLTLLAVSLIISFFISPRVFGFFLIYHFFMWFYSHKLSKVLIINNLTFVSLTLYPFFGMMVYYRTFSVKVFLLAVFLFLMLLVMDIIKDILTKNADKIFGYTTIPNFFGNRITRWVVVTLCLSMMLCSVLIIGKTGVHSILHLYFAAGIAVVLITIYLLLSSHKKSNFFALNILRIWVFVGIIAMLLDGIVNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T4</accession>
    <name>C6X4T4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, BNR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782568.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00971"/>
    <dbReference type="EnsemblBacteria" id="ACU07422">
        <property type="protein sequence ID" value="ACU07422"/>
        <property type="gene ID" value="FIC_00971"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00971"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004232_0_0_10"/>
    <dbReference type="OMA" id="RSINGGQ"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973465" evidence="1">
        <location>
            <begin position="21"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="863"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="937" mass="101907" checksum="2C9EBA82FB125BA8" modified="2009-09-22" version="1">MKLKFIIGVGFTVASLYLNAQVAESDTKNDAKVNKTYLKHIKEIVSSYQKSVQYAKENNQKPPDEYYLHDYIATMDPETGTVNNRNYVLLEEEVRAGKYSPKKELKIFGGVKSSTAKDGITNQWVERGPYSVGGRVRGIMFDPNDATGKKVWAGGVSGGLWFNNDITDSNSEWTLVDAFWSNTTVSCITSDPNNPQIFYVGTGEVETGDFSGLGIWKTTNGGATWTQIFTLESGYTGNVKRGMYNIPTIKVVNNNGMSEVYAGVAGSYFGDTMTFGGLYEAGLYKSTDGTNFTLLSSLLTTPTRGYDIQDIEVGADNAIWVSTRASRFSGSTSGGKIFKSNDHGATFNSVYDVGNSGARVMVEVSETNPLKAYALMQGANTAEPVRIAKTVDGGTTWISTNVLLSGITLPDPIDTGQPNNDFTRGQAFYDLVIETDPANDEHVYVGGIDSYKSTTGGLTWTQFTKWSNNNLLGTTPISLVHADQHALVFNPKNPDQFVMGNDGGVFFAADKNSLASGSAVRMRNNRFNITQFYHGTLNPTATTASEQMILGAQDNGTQQLADAAMPNNFYNSSVVYGGDGAYTAFDDQDKYLIASYVYNYHYLFNGVGQYNLLSVASQRDAGQFINPLAVDRNLDIAYTNATANTTSVTLNRITGLATLPFAPTRTQHNIASVTAGENISDILASPYSTTSTTLFIGLSSGKLFKVTNADTTPVTSLFSFNFGGYISDIKLGASESEIMVTVSNFNKTSVFYSTDGGTNFVSKEGNLPDIPVKAVFMNPEDNNEVILGTYFGVWGTSDFQAATPTWALYSNGLGKFKVNHFDYRPLDKTILAVTYGRGAFTTKIDDVVLSTDGAQHNLLANHVYPNPTRGPLSVKFDARKGNAANIEIFDASGKLVYTKKNVKSEEEFNIESLPKGNYVLKANQNGSMFYSSVIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T9</accession>
    <name>C6X4T9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782573.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00976"/>
    <dbReference type="EnsemblBacteria" id="ACU07427">
        <property type="protein sequence ID" value="ACU07427"/>
        <property type="gene ID" value="FIC_00976"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00976"/>
    <dbReference type="eggNOG" id="ENOG502ZMPC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1617422_0_0_10"/>
    <dbReference type="OMA" id="IPAYRMH"/>
    <dbReference type="OrthoDB" id="1560704at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="174" mass="19781" checksum="711C286F4CCE46A5" modified="2009-09-22" version="1">MDHPKSEKLEIIIPAYRMHSQSFNNALEGISESDALRRINGNTNHVIWMTGNLVSCRYWMASLLGLPDTDPDEKLFFQGRALDENLTYPTLEELKQNFSEISPKVYQNLLTVTGEELDKSAPVGMEIPFVKENVLNMIGMCIGREDYLLGQLGLMRKLLGLPAMSYDFDENLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V9</accession>
    <name>C6X4V9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782593.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00996"/>
    <dbReference type="EnsemblBacteria" id="ACU07447">
        <property type="protein sequence ID" value="ACU07447"/>
        <property type="gene ID" value="FIC_00996"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00996"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_10"/>
    <dbReference type="OMA" id="WQLTMIS"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease_C" evidence="6">
        <location>
            <begin position="508"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="562" mass="62918" checksum="8189D5DC1DACFD01" modified="2009-09-22" version="1">MNQLFRRKHYSESDQPSGLLRVLGVRDIVFFGIAAIIGAGSFSSLGEAVFRGGPGVIILYLICGFACGFTALCYAEFASRIPQAGSAYTYAYASFGELIAWIIGWALIMEYSFGNIYVAFSWSDYFTSFMERIGIHVPDYLSCSYTEAKKAFFGGSENKELLNAWKSAPLIGNHKIIFDLPALVINGLITWLCYVGVKESKNFNNIFVLLKLFIILLVIAVGIAFINTDNWFPVSTDTGVASFMPNGFAGVMTAVSGVFFAYIGFDALSVLSEETKDPQRNLPRGMIISLVLCTVIYIILTLVLTGMVDYRKFDGIGDPLAFIFDAGNANIPWMEFVVSLGAIIAITTVLLVFQMGQPRIWYAMSRDGLMPKKFMEIHPKHKTPAFATIVTGIVVGIPILFTDKSFILDFTSIGTIFAFVLVCGGVLLLPAKQKIKGRFHMPYINSRFIFPLIFIGGLIFFYFWQPEFFQNLLDWNDVAQREFRISVTFFILINLVLCVLAFVRNLSLIPLVGLSSCLYLLTGMSHNNWFWFLVWFAIGMIIYFSYGFRNSKLNNELNGDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y2</accession>
    <name>C6X4Y2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07470">
        <property type="protein sequence ID" value="ACU07470"/>
        <property type="gene ID" value="FIC_01020"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01020"/>
    <dbReference type="HOGENOM" id="CLU_3168359_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="47" mass="4896" checksum="2DE8904A65DDB905" modified="2009-09-22" version="1">MKNTAELKRLLQGEAGAGVEPRKKGGADQWYNGSTSATGGCVPGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y4</accession>
    <name>C6X4Y4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01022"/>
    <dbReference type="EnsemblBacteria" id="ACU07472">
        <property type="protein sequence ID" value="ACU07472"/>
        <property type="gene ID" value="FIC_01022"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01022"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468316_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="377"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="587" mass="66998" checksum="577B12667F47F3B4" modified="2009-09-22" version="1">MTKTCYNNPREQKYPTVPCHFTQTGMSNVYKILLTNCKNMKFKLFFLLLSSIFLYSQTIIQGVVKNEENKNLSYCAIGIKDTNIGAISNEDGFYKITIPEELRDHTVIFKADGYLERSAKVAELNANPNIYLKLKSSNIHEVVLTAKKLKEKIIGEKSRPVLTFSKMFDKNVPTIEQGNIFDIYKKTKLKDFSFHIIPSSKFEQITLKLNIYDLKNSLPNQSILSENIIYKTSSTGWQTIDLSKYKLLFHNLDQIAVTLQLVDSKPLNDTDFVFGISAKKSLSKNLVFRYHSQSKWEKSDGTFLTNLTVGYDKKGIPITDNNSDEHHTESEIEEKLISFYKGREQGLKTIYGKNPDGKYITLDDAKIYYEEYGSGEPLILLEGNNGLISDFYNQIPFLSKQFRVIAMDTRAQGKSSDFAKDDYGYEKLADDLLQIVEVLKLEKVNIVGWSDGGITGLIFNSKNPGLVHKLVTIGANTHPDGVNEELLKSIKKRHHSTTDEKEKRRLNLMINYPNITLEDLNKIKNPVLVIAGDDDEIKLEHTEQLAKMIENSQLEIIEKSTHNVPFDQPEILNNLLVNFLENKKNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X529</accession>
    <name>C6X529_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease, possible major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01067"/>
    <dbReference type="EnsemblBacteria" id="ACU07517">
        <property type="protein sequence ID" value="ACU07517"/>
        <property type="gene ID" value="FIC_01067"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01067"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_10"/>
    <dbReference type="OMA" id="GWNFLVQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="489" mass="51899" checksum="5FB19192A95D6AD6" modified="2009-09-22" version="1">MKDFNSNMENRLQGNDTILAGFILAVLTFWLFANSMLNIAPLMSRQLGIGANSMNIAVSLAALFSGIFVVVFGGLADQIGRTRILRIGLYLSIVGSIIVALIPAGDAAEPLLLVGRALQGLSAACIMPTSLGLLKILWEGPAQQRAISFWSMGTFGGSGLAALFAGIIATNLGWRWIFILSAVVAVIALYLLKELPESKKESAGKYRPDWIGILLFLAAIVCLELFITSGGTLGYLSFTSLALLVAGIVVAVLFYYYEIRTTNHFFDFSLFKNSVFSGAIICNFLMNATSGIIIVALTLMQSAAGYSAQQAGLLTLGYAISVILFIRSGERMMRKIGARKPMVWGSLVVALATLLLMQTYLMTETYRILAIIAFTLFGTGLAFFATPATTAALSNLPADQSGAGAGVFKMASSLGAGFGIAIVAGIFTSVSGSGDTQDWLPELFLGKQDNINYRLAAIPALSAALIFALLSAIVANTKIPKDGGKIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X555</accession>
    <name>C6X555_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3387 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01093"/>
    <dbReference type="EnsemblBacteria" id="ACU07543">
        <property type="protein sequence ID" value="ACU07543"/>
        <property type="gene ID" value="FIC_01093"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01093"/>
    <dbReference type="HOGENOM" id="CLU_3365102_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021810">
        <property type="entry name" value="T1RH-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11867">
        <property type="entry name" value="DUF3387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3387" evidence="1">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="4180" checksum="F84624D9B0AE39FE" modified="2009-09-22" version="1">MGIIVKLHQYGYPPITEDEVYKNVVEQAENFKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X587</accession>
    <name>C6X587_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ordered locus">FIC_01125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805860.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01125"/>
    <dbReference type="EnsemblBacteria" id="ACU07575">
        <property type="protein sequence ID" value="ACU07575"/>
        <property type="gene ID" value="FIC_01125"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01125"/>
    <dbReference type="eggNOG" id="COG2060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_10"/>
    <dbReference type="OMA" id="RQGWAIL"/>
    <dbReference type="OrthoDB" id="296671at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="563" mass="61145" checksum="55AED14B486573EF" modified="2009-09-22" version="1">MNTEILGIIVMFAVSVALAIPFGKYIAKVYGGEKTLPDPLFNPIEKLFYKISGIVPTREMNWKEHMTALLTINLVWFLLGIGILMTQQWLPLNPDNNPNMSADLAFNTTISFVVNCNLQHYSGETGLSYLGQMWLMFLQFVSAGTGLAAAAVLFKAFREKTSVQLGNFYEFFIKSCTRILLPVSFVVALLLVFNGTPMTFDGKDQITTLQGDTVDVSTGPAAAFIAIKHVGTNGGGFFGVNSAHPFENPSYFTNMVEMVAQLIIPLAIIFAFGYFIRRKKFSWMIFGVMTFGFLLLTLPNIHMEMNGNPAIAAMDIDNSTGAMEGKEIRLGAAASGFWSIVTTVISTGSVNSMHDSTMPLSGMNELLAMMVNAFYGGCGVGLLNFFIFIILAVFISGLMVGRTPEFMGKKIEAREMKIAMIIALLHPFLILVGTALATAFPEQGASTLNNPGYHGFSEILYEYTSSAANNGSGFEGLGDNNLWWNITTGFVLILGRFLPIIGPIAIAGLLAGKKYIPEGNGTLKTDTSTFGLMVFAVIAIIAALAFFPALTLGPIAEYFSMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X589</accession>
    <name>C6X589_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805862.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01127"/>
    <dbReference type="EnsemblBacteria" id="ACU07577">
        <property type="protein sequence ID" value="ACU07577"/>
        <property type="gene ID" value="FIC_01127"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01127"/>
    <dbReference type="eggNOG" id="ENOG5032ZJN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2046197_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="120" mass="13991" checksum="3745367D02715CDE" modified="2009-09-22" version="1">MKTELEQCLRLRFTEIYPYGLMAHESDDECTVYRLLRHFGSYCSSHLEAQQTAEIMTVVNELYHSKDLFCQNAIENEFLAVVAEHLRPADLMTHLNRIPAPLQIVYIKVLLEILKHQKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B0</accession>
    <name>C6X5B0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805883.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01148"/>
    <dbReference type="EnsemblBacteria" id="ACU07598">
        <property type="protein sequence ID" value="ACU07598"/>
        <property type="gene ID" value="FIC_01148"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01148"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037929_1_0_10"/>
    <dbReference type="OMA" id="ICFWWFR"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="537" mass="60911" checksum="E2EE622A7FA64EBD" modified="2009-09-22" version="1">MSDYNKGLFKSWVPKPVQLLLILIFTILIMSLNPVNSGNISMMVGDLGIVPDYLMMANFASFIGMATAMPLVLRVKMRFRTKEIMVTSLSVSALLSFVIGTTNVPEIIIASSFIMGFFKMFMMMEFILPLMFILSPDGKRGRFYAIFYPFSIVTGNVAGYYLSKLAYHTTWQYPHFLTAGVCLILLMTAVIFQHNQRFARKMPFSQIDWLSMTFFAATFLCMAYFLSFGKTLNWFEAPAIRVSFWGTLISFVLLALRQLTLKRRYISFGIFTRSNVQSGLLMLLFTGVFLGASSLQSSFAVGVLGYDMVTNASLNIMMVPGVILAGVIAFYWFKAERSLKMFIFSGIAAFFLNSVMMYFMMVPELSYESWLLPMVLKGYGLSALFIAVWFYTLDKLEMESMLQAMGLILVFRSFVATAVFASFFSWLQYQFQWESVNNLAVYLDGNLMSAQSALSGYKSIQLNAILSANKKVYGLICIAAIGMMIYVLQHHFGRLRFSRFRWTKARFTGALRDRRAGKIKILRERVEEVEDAAGAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E3</accession>
    <name>C6X5E3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805916.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01181"/>
    <dbReference type="EnsemblBacteria" id="ACU07631">
        <property type="protein sequence ID" value="ACU07631"/>
        <property type="gene ID" value="FIC_01181"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01181"/>
    <dbReference type="eggNOG" id="COG3204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058234_2_1_10"/>
    <dbReference type="OMA" id="YWFSEEA"/>
    <dbReference type="OrthoDB" id="1688876at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973614" evidence="1">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="293" mass="33169" checksum="9CC12D9542ECD74C" modified="2009-09-22" version="1">MIRLLFLLPLLFVQTITAQQAEIFKLKKYGSAVFSDSLKENSGLTFFNGKLYTFNDGGNSSEIFQINPQSAKIEKTVPTNLTNIDWEAAASDGENIYIGEIGNNAGMRKDLKIYKIPIDTLADSANLTKIIEIPFFYPEQNDFSKRNINNDFDSEAMIFFDGKIHLFTKEWVSKATSHYVIDPNILENQPAKKIEEFPTGYVVTDAEYFKGKLYLIGYTKKTEVFLTIFEESDPGIFFSKKPEKYYLGSSVKVGQIEGIAVDDSGIYISGEQFVNPLGKAKPRLYFVPHGKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H0</accession>
    <name>C6X5H0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805943.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01210"/>
    <dbReference type="EnsemblBacteria" id="ACU07658">
        <property type="protein sequence ID" value="ACU07658"/>
        <property type="gene ID" value="FIC_01210"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01210"/>
    <dbReference type="eggNOG" id="ENOG502Z8F7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107096_0_0_10"/>
    <dbReference type="OrthoDB" id="1397945at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="27445" checksum="8E75E2BA6AAFD035" modified="2009-09-22" version="1">MGKYELEKKIWNETDFEKMGWHDCRIYKIRLTDKLELDIDYILQWNKPDIEGLPFTFWVAPATLVFKKISNIQFEIDTAFDEAVEIEDIELSKSDNKLQWTIITQQGDIEFEADGFTQWIRQEPFFQFGQTISYIERCGFSLEQTTDQDNPNRIRQDIVEQQKKDFEHYENVKKRQLKRKEKSDLEDQRENGKIDLKDYLTKKKEIKEMLDYYDYWLKNTRFENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L5</accession>
    <name>C6X5L5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805988.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01255"/>
    <dbReference type="EnsemblBacteria" id="ACU07703">
        <property type="protein sequence ID" value="ACU07703"/>
        <property type="gene ID" value="FIC_01255"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01255"/>
    <dbReference type="eggNOG" id="COG3457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067103_0_0_10"/>
    <dbReference type="OMA" id="VGCFGGV"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="371" mass="41327" checksum="E6F6AED4E103FEDE" modified="2009-09-22" version="1">MSYITLNSAKLTHNFTFLDRLFAAHHIDWAIVGKLLCGNEQFLRVLLKISDTEICDSRLSNLQVIKKISPQTTTIYIKPPAKRLVKDIVEFADVSFNTEIQTLAALSDEAVRQDKVHRVVLMVEMGELREGIMVQNMVRFYAQVSEMPNLEVVGLGTNLNCLNGILPDREKLIALKQCKEVLEEKFGHRIPFISGGSSVTVPLIFRGEVPPGINHFRVGETLFFGTDVYGDTLISGMYSDVFTLTAEIIELREKPKLPSGLAGTNLTGEKPVYPDEDRDRTSVRAIVDIGLLDIDHKNIAPILPGISIIGASSDMLILDLDTNSAGYKVGDTIEFRMNYMAVLRAMNSDYVDKNVVSRIAAPDLRILQNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q2</accession>
    <name>C6X5Q2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_01292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806025.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01292"/>
    <dbReference type="EnsemblBacteria" id="ACU07740">
        <property type="protein sequence ID" value="ACU07740"/>
        <property type="gene ID" value="FIC_01292"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01292"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_2_10"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="182"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="306" mass="34709" checksum="FC04D4BE06D741C7" modified="2009-09-22" version="1">MKIITNLCEYSSKTPLALSIGMFDGVHRGHQSIFSNLKSIAAQKGLKTAAFTFWPHPRKVFNPADDLKLLNTIDEKTYLISKNGVESLFLKEFDEDFRNLSGEEFVRQILVEKLNVKYLIIGYDHTFGKNKSGDFSLLKKLSSELNFEVEQVEAVDFHDKHISSTQIRNALAEGDVKEANDMLGYVYSVAGKVVHGKKIGRTIGYPTANLEVDAIKLLPKKGAYIVDVFVKNSRYKGMLSIGTNPTVNGETITVEVYILGFSEDIYGEDISVNFREFLHEEIKFENLEKLIERLDEDKRLTENFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U0</accession>
    <name>C6X5U0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806063.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01330"/>
    <dbReference type="EnsemblBacteria" id="ACU07778">
        <property type="protein sequence ID" value="ACU07778"/>
        <property type="gene ID" value="FIC_01330"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01330"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534892_0_0_10"/>
    <dbReference type="OMA" id="ANIMNDF"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972358" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="444"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="514" mass="54671" checksum="6DA7F3C87D284E90" modified="2009-09-22" version="1">MKTKLLSAAFALASVCYVHAQDGLLDLTFNPSGTGASATPRILDIDASGKILIGFGGAGNTYNDAATQNLIRLNADGTIDASFAQYNIGGTQTQYVGAAKNISNGNIIVAQVQRLRTCYDFYSCTFKSDLKLVRMDSTGNIDPFFSNNSYIYSQGGMGSTIPVELAYLAVVEHFSDKVVVGGNFTDYEGSGLQKYSYVVRFDEDGSLDYTFNPGGTGPDGTVSGILKTPSRQLYLSGDFTKYNNVNMGRLTRINPDGTLDSGFNNGGSGFDNTVKTVALQPDGKLLVGGTFTTYNGTPVNNIVRLNADGSLDSTFSSLTFESATGGAVDLTKLIVLDDSKILFSGRFNKYNFVQTGSVGRLNSDGSLDTTFNTGGRGAKILTGTVATNAQITDIATQVDGKILFAGDFNYYNTNGTKKLFYRLTGGTPGSTLATAQPSKVKTELYPNPSTGNIKIRSGEKISRVAVYDRAGKLLRTLTPNAAEVKTDLSGFGTGIYILNVSSGQKNEAYKVVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X6</accession>
    <name>C6X5X6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanophycinase</fullName>
            <ecNumber evidence="4">3.4.15.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate</text>
            <dbReference type="Rhea" id="RHEA:12845"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13734"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137991"/>
            <dbReference type="EC" id="3.4.15.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.15.6" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01366"/>
    <dbReference type="EnsemblBacteria" id="ACU07814">
        <property type="protein sequence ID" value="ACU07814"/>
        <property type="gene ID" value="FIC_01366"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01366"/>
    <dbReference type="eggNOG" id="COG4242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053928_0_0_10"/>
    <dbReference type="OMA" id="FMTGGDQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011811">
        <property type="entry name" value="Peptidase_S51_cyanophycinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032067">
        <property type="entry name" value="Cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02069">
        <property type="entry name" value="cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR032067-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="298" mass="32647" checksum="C97EEB0D20113EFE" modified="2009-09-22" version="1">MHPMRAVGKLMIIGGAVNKGSFSETEYDQNVEKNLNFFERGILRKIIDESCSKKDSVIEVITTASQIPQIVGPEYKKAFEFLGARNVNILDIQTREDANSDAMVARAVAADVVMFTGGDQLRLTSILGGTRFHEAILLKYQEQNFIYAGTSAGAAAASENMIYQGSSSEALLKGEIKTTQGLGFIENVIVDTHFVQRGRIGRLFQSVVNNPRTLGIGLGEDTGLYINGDTMTAIGSGLVILVDGRFIKDTNLTKIELGQPISIDNLTVHVMSQNDFFDLKTKEFTIVNSQYNPIPQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X605</accession>
    <name>C6X605_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01395"/>
    <dbReference type="EnsemblBacteria" id="ACU07843">
        <property type="protein sequence ID" value="ACU07843"/>
        <property type="gene ID" value="FIC_01395"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01395"/>
    <dbReference type="eggNOG" id="ENOG502ZBUH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120969_0_0_10"/>
    <dbReference type="OMA" id="KVIWENI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="179" mass="21159" checksum="C19C0DC4EE1CE876" modified="2009-09-22" version="1">MSNFASSLFCMINWPYFPYAFALLLAIPFLIFIRQFVYTYIKLKNKEIKLLTVKGNSEQRVHAYERLTLFLERLKPSNLVAKFDSKLAPHEYIFLIEKSINEEFDYNASQQLYLTKNLWKNVVNSKNNVLRLLHSTYENLGEGATLDEFKTVFLMNYMNQSDFVLQCIDDLRKENLIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A7</accession>
    <name>C6X6A7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806230.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07945">
        <property type="protein sequence ID" value="ACU07945"/>
        <property type="gene ID" value="FIC_01498"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01498"/>
    <dbReference type="HOGENOM" id="CLU_2806167_0_0_10"/>
    <dbReference type="OrthoDB" id="2071530at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="67" mass="7047" checksum="EEEE008D22CE249E" modified="2009-09-22" version="1">MKNLFAAAFVGMFILAACSQKETNVESNTMLEEPEVTVQDSPTQAYGDGSPVAPDSVSIDPQTPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D6</accession>
    <name>C6X6D6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane protein probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806259.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01527"/>
    <dbReference type="EnsemblBacteria" id="ACU07974">
        <property type="protein sequence ID" value="ACU07974"/>
        <property type="gene ID" value="FIC_01527"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01527"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OMA" id="QGNIKHE"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970741" evidence="5">
        <location>
            <begin position="24"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="403"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="940" mass="104642" checksum="40EA81B5CF2E5242" modified="2009-09-22" version="1">MKHSILKLPCVIAVFYFGMSVEAQQTPQDTLSKEQAIEEVVVIGYGTAKKRDLTGSIVRVAGEEVNDKPASNPVNSLQGKVAGLSVVNSGQPGSQADVRIRGTVTINQTQPVYIVDGVFANNIDFLNPADIESMEILKDASSLAIFGNRGANGAIIVTTKRAKSGRTSISFNSSVGVKSFDNRPDLANAELFKTLYNEDRAGQGIAPYDFSLFNADTNWIDVIKKNGGIINQHSVTMSNGSDKNRVSFSFGYHNEEGSIMYEDYSRMTIKFNDDLKVTDHFRVGMGLTGAYAKLPQLRSFASALNATPVVAPVNLTPGDYYGLFNSLPQQIGAAQIGNPLAVVEGQRNTQLNRDFQFNPNAYLEFDFLENFTFRSNYFVTYRNGTGRGYSPIFDVYIAETNTSAPYSGQLLTSINQFENRDITFQQNQLLTYQNDFGEHDLTLMAGFETTSREYTQMSASARSSLSNPFGQIPNNPRFWYLNSEFVDSTTKNVNSSQYKTRNVSYFGRMLYNFSNKYLLNASIRNDGSSALAPGNRFDWFWAVGAGWEITRENFMKDSSFINYLKLKGSYGDLGNQYTPYNYFGYPVFVEGGTGVFNDNLYPAYVKAFEESADLGWEHLKSYEFGFESLILDRRLSLDATYYNKKTQDLLNYVPGNPNFFQNAGSIEAKGLEVSMGWKDNISEDLTYYVNGNLTTTKTKVLSTLSPGYTVYSGPSIYQEGLPVGAFYGYVVEGLFQSYADILSSPASTIGDVAPGDFKFKDVNGDGKISADDRTLIGDPTPDFTYGFSVGGDYKGFYLNADFYGVYGNEVYRDWGNGSSFAPFNYRAERIDRWTGAGTSNWEPRINSASGYNRENSSYMIEDGSFFRIRNVQLGYNFNRDLISAFNMHSLKLYFNIQNLKTWDHVNGFTPEFGGSATQFGVNNSGYPNPRITSLGINATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D7</accession>
    <name>C6X6D7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806260.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01528"/>
    <dbReference type="EnsemblBacteria" id="ACU07975">
        <property type="protein sequence ID" value="ACU07975"/>
        <property type="gene ID" value="FIC_01528"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01528"/>
    <dbReference type="eggNOG" id="ENOG502Z7PK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1238389_0_0_10"/>
    <dbReference type="OMA" id="QNSTALM"/>
    <dbReference type="OrthoDB" id="1267322at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025245">
        <property type="entry name" value="DUF4197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13852">
        <property type="entry name" value="DUF4197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="227" mass="23782" checksum="ACCD55D2E4DA2840" modified="2009-09-22" version="1">MNRNTILTATMAIATLGTATQSCVALATSSVGLAVLKQILLGGITKGLNIFSDKDSFLANQLIDAAMPQQLRDLNSTLQKVGLNSLVQKEKQYIAQAAAFTVDVSRPILINAVNRMTAEDAARIVQGGSGAATQILKEKTSEQLMAAIAPRVDAKLNEFGLVSSLNSALSGTNLLGGLFGNQASTSSVTGGISRFASQQMVNGLFNIIQSHEQQNSTALMNSLNGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F3</accession>
    <name>C6X6F3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806276.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01544"/>
    <dbReference type="EnsemblBacteria" id="ACU07991">
        <property type="protein sequence ID" value="ACU07991"/>
        <property type="gene ID" value="FIC_01544"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01544"/>
    <dbReference type="eggNOG" id="ENOG5032SI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138456_0_0_10"/>
    <dbReference type="OMA" id="AGVLVYC"/>
    <dbReference type="OrthoDB" id="1779307at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="127" mass="15102" checksum="0360CDC9546AF0DE" modified="2009-09-22" version="1">MQELKIYEYAVIRLVPKVEREEFFNIGLVMFSKREKYIRVEFHLCPNKFQLMHSKLDYDDVQKNLENFRHVAHGDKAGGEIATFDIPERFRWLTAVRSSVVQTSRPHPGKTRDLDGTFERLFEELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G5</accession>
    <name>C6X6G5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ordered locus">FIC_01556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01556"/>
    <dbReference type="EnsemblBacteria" id="ACU08003">
        <property type="protein sequence ID" value="ACU08003"/>
        <property type="gene ID" value="FIC_01556"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01556"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_1_10"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="103"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="24972" checksum="13D5784E99F862D9" modified="2009-09-22" version="1">MYPKIIKAARLAPCRIKFYFCGMDYPSKVLAKAVEEISGLPGIGKKSALRLALHLLKQPETQAVALGDSLKKLVTEIKYCRECHNFSDHEVCDICANPKRTEEIICVVEDVRDVMAIENTGKYRGKYLVLGGKISPMEGIGPNQLNISSIGKKLEKAGAKEIIFALSATMEGDTTAYYIYRKFKDSGVNFSTIARGISVGDELEYADEISLGRSIQNRLPYHDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H3</accession>
    <name>C6X6H3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806296.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01564"/>
    <dbReference type="EnsemblBacteria" id="ACU08011">
        <property type="protein sequence ID" value="ACU08011"/>
        <property type="gene ID" value="FIC_01564"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01564"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016090_0_0_10"/>
    <dbReference type="OMA" id="GPFEQTF"/>
    <dbReference type="OrthoDB" id="120742at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045670">
        <property type="entry name" value="DUF5916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19313">
        <property type="entry name" value="DUF5916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972376" evidence="1">
        <location>
            <begin position="20"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="2">
        <location>
            <begin position="43"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5916" evidence="3">
        <location>
            <begin position="236"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="808" mass="92509" checksum="E54491A3FCF7A982" modified="2009-09-22" version="1">MKTKIPCLALVLACTLGTAQKTTGDSIARKTVTAVQINQQVKIDGILDEEAWQTTNAAANFVERRPNNGKAEPDSLKSVVKVLYDDTGIYFGAMLYDTNPAKIAKELTERDNIENDDIFGITLNGYNDHQQSLEFLLTPAGVQADAKLTTDFGEDFSWNAVWFSAVKITENGWVVEMKIPYSELRFPKKNVQEWGINMLRLVNRTSTMYDWNFVDNKKGSYMLYDGVLAGIENINPPTRLSFLPYFSTYLNNYDGKTTANVNGGMDLKYGINDAFTLDLTLIPDFGQTSFDASVLNLSPFEVQFDEQRPFFTEGTELFSKGDLFYSRRIGGNPTHSPELSDEEEIVENPEKVKLFNAVKISGRTNKGLGVGFFNAVTEKTSAVIRNIDTGETRREVTEPWANYNVFVLDQRFRGNSSVSLVNTNVTRDGSFRDANVTALLFDIRNKNNTYQYFGGTKGSFVMNGETKFGNESSLGFNKVSGVHRFGANYFVRTKDYDIGDLGYYDRTNFHSINTNYSYRFLQPKGNLNNLNYNLNVSHNRRLGDDIFTQFVIHNSIEMQTKKFFSFGGGLMIWPFGENDIYEPRTAGRHLDVPAMINPWIFINTDNRKKFRINTFIDYYAFDEKGRYQLIYQLNPSYKFSDKLRLYYNANFNYQNNDRGFVGADAEQIFMGSRNRFTVENGISSQYTFNNKMALNLSFRHYFSQVHYKNFSTLNANGSVSGTDLFTENRDGTFNSWNVDLRYSWWFAPGSQLTLLYRNAVGNYVPESKLGVKRNFDRLFEEPMVNSISLKLTYYIDYNQAKTWFKDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I2</accession>
    <name>C6X6I2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor protein for response regulator AtoC</fullName>
            <ecNumber evidence="3">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01573"/>
    <dbReference type="EnsemblBacteria" id="ACU08020">
        <property type="protein sequence ID" value="ACU08020"/>
        <property type="gene ID" value="FIC_01573"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01573"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709295_0_0_10"/>
    <dbReference type="OMA" id="NESWIED"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="389" mass="44908" checksum="2647516D892689B7" modified="2009-09-22" version="1">MLLILISLYPPKEENAARMFAQTLHLNLKKIMSNDDQRVQELTDHNDLLENYFRNTIIPQLFVDGDLKLQKFTPPAMKQFSLRDTDVGRHIDDIKDNFRFPSIVENIQHVIESNEILEKEIQTTDLRWYQMNIIPYVRLRDKKSDGVIITFVEITMRIKDLREQEKLIADYEILLDTISHDIKNPLTNLVLAIDLFKRVSPNDEKKFQSLLKIVDSALSTMHGVITDLTEERKSGYKYRTDDELLNFEHILEDVRLTLKDDIKAANATITSSIGVSELTFSRRKLRTVLYNLINNAIKFKATDRDPKIEVSTGSEGEFVVISVKDYGRGIEKAQLEPIFSKYHRFQKDIEGSGIGLHLVKEIVSSSGGKVSVESVVDEWTMFKVYLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB5</accession>
    <name>C6WZB5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782130.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00525"/>
    <dbReference type="EnsemblBacteria" id="ACU06983">
        <property type="protein sequence ID" value="ACU06983"/>
        <property type="gene ID" value="FIC_00525"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00525"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_10"/>
    <dbReference type="OMA" id="VHHQTLG"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="7"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="113"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="319" mass="34534" checksum="77AED9E1C3924949" modified="2009-09-22" version="1">MKILANDGLDQSGIDALTEKGFEVITTKVPQDFLKEFINAYNIRTLLVRSATKVRRDLIDACPSLEIIGRGGVGMDNIDVDYARSKNIHVINTPAASSESVAELVFAHLFTGARFLQDANRRMPLIGDTEFANLKKTYERGIELRGKTIGIIGMGRIGQEVAKIALGLGMKVIAADSNVGRTSIKLTFYNNQFINVDIETEPLEGVLKHADFITLHVPSQKDGYMIGAEQFAMMKDGAAIINCSRGGVIDEDALLSALDSGKVSFAGLDVFINEPTPSKAILTHSKISLTPHTGASTLEAQDRIGLSLAKQICSILQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB8</accession>
    <name>C6WZB8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ordered locus">FIC_00528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782133.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00528"/>
    <dbReference type="EnsemblBacteria" id="ACU06986">
        <property type="protein sequence ID" value="ACU06986"/>
        <property type="gene ID" value="FIC_00528"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00528"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_0_10"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="289" mass="33134" checksum="2F44F004A997429F" modified="2009-09-22" version="1">MLTLLYTTWDPSTGIHLGPITLHYYSLMFILAFGLGYIIMTKIYKIDNVNVKYVEPLFTWTLVGTILGARLGHVIFYQPELFKQDFWSVFLPIQTVPEFKFTGFAGLASHGATIALIFTTLYYAFKIIKKNPLWVYDRIGIVVALGGAFVRIGNFFNSEIIGKPAPEGSPFAVLFPQQSPEYGAIVARYPTQLFEATGYFLLFILLWVLYRYTKKKYQQGWLFGLFFIILWAVRFFVEFLKEPQGDEFIQFAGLNTGQVLSLPFMLAGFVIMWYSTKNIITEEENGKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC3</accession>
    <name>C6WZC3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00499"/>
    <dbReference type="EnsemblBacteria" id="ACU06957">
        <property type="protein sequence ID" value="ACU06957"/>
        <property type="gene ID" value="FIC_00499"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00499"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002997_1_0_10"/>
    <dbReference type="OMA" id="GKFNMWG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1608"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1622" mass="179288" checksum="9BD7CEC2C3673378" modified="2009-09-22" version="1">MAAIFERIVFPRMMAAEVSSHDDSIPNIIDSLITMANLENNNDNEPKKSVAENIGDSVQKGVENLQHTVKGATQLASDAIKHPVDTAGEFVDQAAKDVTNYKWWAKLLLVLFWVTIFIVATFFIVVSLPATKNWAAQKVIAKLNNDMKAQMSFESVDVNYFGDIHIHKVGIKDYKNFQFLKAEELYADSDWFSIISNSRNMQFQSLSLKELDLKVITYKGDSISNFVRFVDLFNTPSPTTPREPFQLKSRVYVTNSKISIVNQNSEGEAGRWLSAENVNLAVPELRVNGSDVFAQINNLRFTTERWGKKHFVDTFSTDLSLTKKFLSLKDLTLNTDNSLLQGDLKFNLNNGSWADFADRVRWDMTLQPGSQISGHDISYFVTNWDNYKPVNVSGNMSGPLNRFYLDNFLLRNPDVNIRTGTMKVSNILKGNFQIETNTLSTDFTYKELKDMMPTFISSKMKNFADDFGRLKYNGAVRVTPKQVYVPNARLITGIGQAKISNFYLDDYSSNMPKYRGYAEVNDLNTTVITKSPQVGLVSGKFNVQGQSFDVNTMRIRTRSQISSIEIMNKEINNVFLDGLLDRRTYKGIVNVNDEQAKADVNGFIDFRTAKIAADVAADVKYLNINYFTGSSGNQIVSGFVDGKVSMTNLNDLNLDADLRNVSFATATQNFNIPNAKVRAYFENGNRVVSVDAPGAVNGQISGKFNLGDLPGMIQNGISKILVGPPPRKLYRGQNFSMDFDIKQGLVNYFEPNLSIPNGASVNGSYEGTGNNLILNLDARTLKYVMTKKVEITEADRALAAANPAYKITDRDRISRDSAMVDSVMVRINTANLDEQIFARIARVAYNQNILKDITLSGRNENNQMLHVAAQFKHGTPEDEVKQTLREYAVNLNQTSNAAGDYVFRFEPTAVKFNDVEWNVDTSEMLNHSITYRKKSGDFLIQNLRLYSDSSELFLSEALFKSAKDFSAAGELRNLDIAKVFALLNTDNSMDIQGLANGTFDIKMNQSNLQPLIDLNVTDIFMNGKDMGNVVISAKQSSVPNVFDVEARVVSAGIIGDNNLFLTGTINNNTSSPTLDLTANLNEFDLAFAQEFVKGVFGNLRGNASGDLKISGPLSDIDYSGDIAMKGLGLKLNFTGVDYSLDDTVISLSRGLAILNDIGVKDGRANSRGTISGAIQFQTLSSMGVNLVMRADNLLLLNTTQKDYDLFWGRVYGSGTLYVDGPVSALNISTPEMTALSNSVFTFNSNSTSNVEEFKMLRFLKRDEAGVVTTEDKRRSSANMTIDFTISVDRGTTVNVMVGDDIGDITVRGNSEKLRFRMARTGTIAMNGDYFVDNGTFVSKAILNRTFQITKGSSIRWDGDAMSPELDINATYLRTVNNAGPYLNMGSLQPINVLLSTKITQTLNNPKVELGVSAEDVSSSLRETLAEKMSNEDEKIIQFGSVLVMNSFNVGNSAFDINLGTTLETSGYNMLFKQLGSVLNQISNEFQVDLNYLQGDTNSNSGDRANASVSFALSPRVTVKTGLGIPISKSENTNADYLSGEGIIEYDWSKNNDGTRLLRAYSKPTNIGLNGAAAGNASANQSYGVGVVYSKSFNTIFKRKKSKKNNADTAETKSNSTKNDTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF0</accession>
    <name>C6WZF0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781632.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00007"/>
    <dbReference type="EnsemblBacteria" id="ACU06485">
        <property type="protein sequence ID" value="ACU06485"/>
        <property type="gene ID" value="FIC_00007"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00007"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_10"/>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="27330" checksum="E5A5125362C44614" modified="2009-09-22" version="1">MKTAFITGATSGIGKATARLLASQGFRLILCGRRADALKEISAELSALTEIFSLNFDQRNRDEVETSFKSLPSEWQTVDVLINNAGNAHGLDSIADGNPDDWDAMLDGNVKGLLYVSKMIIPGMKERNSGHIVNISSVAARQTYANGVVYCASKRAVDVISEGMRLELTEFGIKVTNIQPGLVETDFSKVRFKGDEERADAVYQGYKALEAKDIADAISYCISAPEHVTISDLTIYPKVQSEPRTVYKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH0</accession>
    <name>C6WZH0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781652.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00027"/>
    <dbReference type="EnsemblBacteria" id="ACU06505">
        <property type="protein sequence ID" value="ACU06505"/>
        <property type="gene ID" value="FIC_00027"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00027"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067823_1_0_10"/>
    <dbReference type="OMA" id="PSYHIGA"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="44"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="255" mass="29724" checksum="4F5A4632625D9E63" modified="2009-09-22" version="1">MLKESLNYKAVYYAAAMVGAMWLGFLLQNFGFLSGCEGAIIPLHPDGLKGIFFSPFLHGNLEHLFGNSVPAFVLIFLLFQFYPSIAKQVFFIGWFVALFLVWLLPPIDFFTGEYNYVCIVGASGLVYVLAFFIFFSGVFRWHMKLLTVSLVVALYYGGLVWGVMPEELFSTLEEPSRISWQSHLSGAVVGIMLAFIFRKSGEKDKRFIWQFPNYYSEKDDKLWQEYKEKYPDDFHELPYRKEENEWEHLDKIRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH4</accession>
    <name>C6WZH4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ordered locus">FIC_00031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00031"/>
    <dbReference type="EnsemblBacteria" id="ACU06509">
        <property type="protein sequence ID" value="ACU06509"/>
        <property type="gene ID" value="FIC_00031"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00031"/>
    <dbReference type="eggNOG" id="COG0423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_10"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="183"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="378"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="256"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="266"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="519" mass="60003" checksum="E3042B3617751EFA" modified="2009-09-22" version="1">MLKIITMAKQEDVFKKLISHAKEYGFIFPSSEIYDGLSAIYDYGQNGAELKNNIKQYWWKAMVQMNENIVGIDSAIFMHPTIWKASGHVDAFNDPLIDNKDSKKRFRADVLLEDYCAKLEEKAQKEIDKAAKRFGDTFDKNEFETTNGRVLEYREKQKTILSRMAKSLENEDLADVKSLIEELEIADPDTGSKNWTDVRQFNLMFGTKLGASADSATDLYLRPETAQGIFVNFLNVQKTSRHKLPFGIAQIGKAFRNEIVARQFIFRMREFEQMEMQFFVPPGTELDFYEEWKQKRLNWHLALGLGAENYKFHDHEKLAHYANAAADIEFKFPFGFKELEGIHSRTDFDLSAHEKHSGRKLQYFDSERNENYVPFVVETSVGLDRLFLAIFSNSLKDEVLEDGSERTVLSLPPALAPVKAAILPLMKKDGLGEYGEKIFNDLKFDFNVIYEDKDSIGKRYRRQDAIGTPFCITIDHDTLKDNTVTLRDRDTMKQERVAVADLRRIIDEKTNFRNLLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL9</accession>
    <name>C6WZL9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00078"/>
    <dbReference type="EnsemblBacteria" id="ACU06554">
        <property type="protein sequence ID" value="ACU06554"/>
        <property type="gene ID" value="FIC_00078"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00078"/>
    <dbReference type="eggNOG" id="ENOG5032RR7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114082_1_1_10"/>
    <dbReference type="OMA" id="RFSFFYD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="199" mass="22354" checksum="9D4B7F6087E488B9" modified="2009-09-22" version="1">MGFRSARSTEKSNNTILRIKMKHDFKLNNTRFLAVTTVLLVILQSCYSFTGSSLSPETQTILIREFPNNAALMNPNLSQQFSTDIQNRFLQRTTLKGTTESPDILIEGEIVDYSITPTTISSAVNAPGGNIQAAQNKLTITVKVHYENKIEPDKSFDRTYSDEAVFSSDLDINTIETSQVKVVNERIINKIFNDIVANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV3</accession>
    <name>C6WZV3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal large subunit pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781785.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00163"/>
    <dbReference type="EnsemblBacteria" id="ACU06638">
        <property type="protein sequence ID" value="ACU06638"/>
        <property type="gene ID" value="FIC_00163"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00163"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_2_10"/>
    <dbReference type="OMA" id="FTEPAHR"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="233" mass="26238" checksum="FE9C0724A94EEB0B" modified="2009-09-22" version="1">MQESQKNTIESQIVFEDNHLLVINKKAGQLVQGDKTGDASLLDLIKDFIKKRDNKAGNVFLGLVHRIDRPTSGLVIYAKTSKALTRLTQMVKNREIKKTYWAVVPKEVIPHSARLLHYLQKNEKTNKSTVFIKPTENAKESVLNYTVIKTLDNFQLLEIDLETGRHHQIRAQLSKIGVPIKGDLKYGASRSNPDGGIHLHARKLEFIHPVSLKNTEIVAPLPAHDAVWAACEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV9</accession>
    <name>C6WZV9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogen peroxide-inducible genes activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781791.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00169"/>
    <dbReference type="EnsemblBacteria" id="ACU06644">
        <property type="protein sequence ID" value="ACU06644"/>
        <property type="gene ID" value="FIC_00169"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00169"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_10"/>
    <dbReference type="OMA" id="LPAPYCR"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="314" mass="35797" checksum="19EBF4DD08969E05" modified="2009-09-22" version="1">MNIQQLEYLIAVDKFRHFGKAAQSCFITQPTLSAMIQKLEDELAVKIFDRTTHPIRTTDVGVHIIEDAKRVIDAVNELRNKASLLNNVLAGKLNLGIIPTISSYILPSEIFDFLKEHPKIELNVKEMTTDNIIKSLKSGELDAGIISTPYDAASEFYQDFLFNEELMVYSSDTGKKDSFVLPEEIDSNKVWLLEEGNCLRTQFENICMLKENSLKPKNLDFLASNINTLIQMVDRVGGITILPELAVPQLSVDQKEKVVRFRKPFPFREISLIYYKPTYKQKILDEMALSVKKSLAEKLSYNQNPEDFVSVKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZX2</accession>
    <name>C6WZX2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topA</name>
        <name evidence="11" type="ordered locus">FIC_00182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781804.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00182"/>
    <dbReference type="EnsemblBacteria" id="ACU06657">
        <property type="protein sequence ID" value="ACU06657"/>
        <property type="gene ID" value="FIC_00182"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00182"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_3_2_10"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="162"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU06657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="851" mass="96405" checksum="3C61570DA6F676FC" modified="2009-09-22" version="1">MSKNLVIVESPAKAKTIQKYLGKDFEVKSSFGHIRDLPKKGMGIDLATFTPDYEVSADKKKLVTELKAAVKKADIIWLASDEDREGEAIAWHLAQELKLNKDNTRRIVFHEITKNAILKAIENPRKIDQNLVNAQQARRILDRIVGFEMSPVLWKKVKTGLSAGRVQSVAVRLVVERELEIRMFQPKSSFKVEGVFFNTNKQDISAKLKKDFAKEQEAEAFLQQAQDVEFKVLNVETKPGTRTASAPFTTSTLQQEASNRLGYGVTATMRVAQRLYEEGFITYMRTDSVNLSQEAITGAQAQIIAEFGEEYSKPRNYTTKSSSAQEAHEAIRPTDFGTKNVPDAQLNKLYQLIYKRTLASQMTNAKIEKTVIEIGNPKLPQHFEAQGEVIVFDGFLKVYGITKAEDDEEENNEKLLPKVSVGETLDFKKIDATEKFTRPPARYTEAGLVKKLEELGIGRPSTYAPTIQTIQNREYVDKREVLPQEREIIRMTLGREGLKKEVVNEKFGGDKNKFLPTDIGEVVNDFLTQNFAEILDYGFTAKVEQDFDEIASGDEKWKDVLQGFYKDFHPKIEHVEENADRANGERILGKDPKSGKNVLTRIGRFGPMVQIGEQDDEEQPIFASLMPSQNIATITLEEALELFKVPFDLQEYQGKPVMVGVGRFGPYVKWGDAFISIPRGEEALSITQERAEEIINEKQIADAPIATYKGEPVTKGTGRFGPFIKYQSLFINVPKRYDFDNLSQDDINELIEAKLTKEANRYIQQWESEKISIENGRWGPFVKFGKAMFKIPKNKKDEKFTPEELAEIPLEEVKKWITAQDKNAFKEKPKKAAAKKAPAKKAPAKKTVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY5</accession>
    <name>C6WZY5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00195"/>
    <dbReference type="EnsemblBacteria" id="ACU06670">
        <property type="protein sequence ID" value="ACU06670"/>
        <property type="gene ID" value="FIC_00195"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00195"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_10"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="261" mass="30293" checksum="EF9764F894A697D4" modified="2009-09-22" version="1">MEGRHAIVENKMQTFKDKIAPDHLPQHVAIIMDGNGRWAKSRGQKRTFGHKHAIKAVREAVNACNEIHIPYLTLYTFSSENWNRPEDEVDTLMGLISETLILEAEEIFTKGLRMHIIGDIEKLPQLVREQMQHLVDITKDNKQGNLILALSYGSHSEMLNAVKQISTKVKNGELSEEQITEKVFEDHLYTKDFPPVDLLIRTSGEVRISNFLLWQIAYAELQFLDILWPDFGREDFFKCISDYQHKERRFGKTSEQLEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X025</accession>
    <name>C6X025_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781857.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00236"/>
    <dbReference type="EnsemblBacteria" id="ACU06710">
        <property type="protein sequence ID" value="ACU06710"/>
        <property type="gene ID" value="FIC_00236"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00236"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147365_1_0_10"/>
    <dbReference type="OMA" id="VIANTFN"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="133" mass="15623" checksum="0C6DD1FD3E5C3F70" modified="2009-09-22" version="1">MEQKIHQGRNVKRFREMLGIKQEALAFDLGDEWNQKKISLLEQKDVIEDPLLKKISEVLKIPVEAFQNFDEEAAINVIANTFNNHDHSNPQFASVINNSPTFNPIDKMVELYERMLEQQKDMIEKLEKLIQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X042</accession>
    <name>C6X042_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="8" type="ordered locus">FIC_00254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00254"/>
    <dbReference type="EnsemblBacteria" id="ACU06727">
        <property type="protein sequence ID" value="ACU06727"/>
        <property type="gene ID" value="FIC_00254"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00254"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_10"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="87"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="370"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="471" mass="52142" checksum="354A1DCA07889BD8" modified="2009-09-22" version="1">MWSCSLISALKSGCLNYFQEIRSMAKVKTAYFCQSCGTQYPQWLGQCKNCGEWNTLVEEIIEKSPVKSGSDRNKQHIINIIEVETHEEPRIATPSEELNRVLGGGIVLGSVTLIGGEPGIGKSTLLLQLALKMKKKVLYVSGEESASQIKMRADRLTELQNPNCFLFTETSVEKILHEAKKLKPDFVVIDSIQTLQSQLIESSPGTVSQIRECSNEIIKYAKDSNTPVFLVGHITKDGQIAGPKVLEHMVDVVLNFDGDRNHLFRLLRASKNRFGSTAEIGIYEMVSQGLKEIKNPSEILITKKFEELSGNSVAVTLEGNRPMLIEIQALVSSAVYGTPQRSCTGFDSKRLNMLLAVLEKRAGFQLGSKDVFLNITGGIKTDDPALDLAVVASVLSSNEDIAIPEHYCFAGEIGLSGEIRPVSQIEQRISEADKLGYERIFVSNLNKIPKKKFGITIVEVSKIEDFHEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X048</accession>
    <name>C6X048_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ordered locus">FIC_00260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781880.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00260"/>
    <dbReference type="EnsemblBacteria" id="ACU06733">
        <property type="protein sequence ID" value="ACU06733"/>
        <property type="gene ID" value="FIC_00260"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00260"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_10"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="541" mass="57414" checksum="936278F385AB27AE" modified="2009-09-22" version="1">MAKEIKFDVESRDALKRGVDALANAVKVTLGPKGRNVVIEKSFGAPHVTKDGVTVAKEIELEDRVENMGAQMVKEVASKTNDIAGDGTTTATVLAQAIVREGLKNVAAGANPMDLKRGIDKAVTAVVQNLKSISQEVGDSSEKIRQIASISANNDDTIGALIAEAFGKVGKEGVITVEEAKGTDTTVDVVEGMQFDRGFQSPYFVTNPEKMITELENPYILLVEKKISSMKELLPVLEPVAQAGKSLLIISEEVDGEALATLVVNKLRGSLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEERGFTMENATLEMLGTAEKIVIDKDNTTIVNGAGDEAQIKGRVNQIKAQMESTTSDYDREKLQERLAKLAGGVAVLYVGAASEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALVRSIAVLQNLEGANFDESTGIKIVKRAIEEPLRQIVANAGGEGSVIVAKVADGDADFGFNAKTDEYVNMYEAGIIDPTKVVRVALENAASVSGMLLTTECVITEVKKDEPAMPMGGGMPGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X062</accession>
    <name>C6X062_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ordered locus">FIC_00279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781894.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00279"/>
    <dbReference type="EnsemblBacteria" id="ACU06747">
        <property type="protein sequence ID" value="ACU06747"/>
        <property type="gene ID" value="FIC_00279"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00279"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_1_10"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="122" mass="12595" checksum="AD7857F937757F72" modified="2009-09-22" version="1">MSDLKNLAETLVNLTVKDVNELATILKDEYGIEPAAAAVVMSAGGGAEAAEEKTEFDVILKAAGGSKLAVVKLVKDLTGAGLKEAKDMVDSAPAPIKTGISKDEAEALKKQLEEAGAEVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X063</accession>
    <name>C6X063_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="15" type="ordered locus">FIC_00280</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781895.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00280"/>
    <dbReference type="EnsemblBacteria" id="ACU06748">
        <property type="protein sequence ID" value="ACU06748"/>
        <property type="gene ID" value="FIC_00280"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00280"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_1_10"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="31"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="306"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="478"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="556"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="685"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU06748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1275" mass="142791" checksum="BE676566FF2EF16B" modified="2009-09-22" version="1">MSKSKAVAKTQGTERINFSAAKGKIETPDFLDIQIQSFKDFFQLDTLPEQRANEALYKTFEENFPITDSRNQFVLEFLDYLVDSPRYSIDECVERGLTYSVPLKARLKLYCTDPEHEDFQTVVQDVYLGPVPYMTPSGSFIINGAERVIVTQLHRSPGVFFGQTYHANGTKLYYSRIIPFKGSWMEFTTDINNVMYAYIDRKKKLPLTTLLRAIGFESDKDILQIFDLAEEVKVSKAALKKVEGRTLAARVLNTWFEDFVDEDTGEVVSIERNEIILDRETVLEKEHLDLILDAGVKSILIHKENSNEFSIIQNTLQKDPTNSEKEAVEYIYRQLRNADPPDEETARGIIEKLFFSEQRYSLGEVGRYRLNKKLGLNIPAKTEVLTKEDIISIVRHLIELVNSKAEVDDIDHLSNRRIKTVGEQLSGQFGVGLSRIARTIRERMNVRDNEIFTPIDLVNAKTLTSVINSFFGTNQLSQFMDQTNPLSEITHKRRLSALGPGGLSRERAGFEVRDVHHTHYGRICPIETPEGPNIGLISSLGLYAKINSLGFIETPYRKVTNGKVDLKTTAVFLNAEDEEDKVIAQANVEMKEDGTISTDRVIARLDGDYPVVEPQQVDLIDVAPNQISGISASLIPFLEHDDANRALMGSNMMRQAVPLLKPEAPIVGTGLEQQVARDSRILINAEGNGTVEYVDADKITIKYERTEDDDLVSFESATKTYKLTKFRKTNQSTTITLRPNVRVGDKVQKGQVLCDGYATENGELALGRNLVVAFMPWKGYNFEDAIVINEKVVREDWFTSIHVDEYSLEVRDTKLGMEELTADIPNVSEEATKDLDENGMIRIGADVKPGDIMIGKITPKGESDPTPEEKLLRAIFGDKAGDVKDASLKADSSLRGVVINKKLFSRNIKDKKKRTEEKLKLEEIENTYKAKFDQLRNTLLEKLGTLVNGKTSQGVNNDLDEEIIGKGVKFTTKLLQSVEDYVNVSGADWTVDADKNELIKQLIHNYKIKFNDIQGVKNREKFAISIGDELPAGIIKLAKVYVAKKRKLNVGDKMAGRHGNKGIVSRIVREEDMPFLEDGTPVDIVLNPLGVPSRMNIGQIYETVLGWAGQKLGLKFATPIFDGANIDQITGYTEQAGLPEFGSTYLYDGGTGERFSQPATVGVIYMLKLGHMVDDKMHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAFGASNILREILTVKSDDVIGRAKTYEAIAKGEAMPEPGIPESFNVLLHELQGLGLDVRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X079</accession>
    <name>C6X079_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781911.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00297"/>
    <dbReference type="EnsemblBacteria" id="ACU06764">
        <property type="protein sequence ID" value="ACU06764"/>
        <property type="gene ID" value="FIC_00297"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00297"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147162_7_0_10"/>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="94" mass="10873" checksum="4F0D6A71C1F73408" modified="2009-09-22" version="1">MQVLISAEAQSEFRHAVKFYEKRQKGLGKKFSNAVKSKSNFLQSNPEAAEIKYLQIRVTTVKGFPFTIHYTHSDKKILVVAIFHNSRHPDQLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X090</accession>
    <name>C6X090_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ordered locus">FIC_00308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781922.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00308"/>
    <dbReference type="EnsemblBacteria" id="ACU06775">
        <property type="protein sequence ID" value="ACU06775"/>
        <property type="gene ID" value="FIC_00308"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00308"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_1_10"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU06775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="21143" checksum="0C0A890FCF4E9FCC" modified="2009-09-22" version="1">MNKVLIFSAPSGSGKTTLVKHCLEVFPELSFSVSCTTRSPRGSEVDGIDYHFITPDQFRAKIAEDAFVEFEEVYEDKYYGTLKSEVDKIWSSGKVVIFDVDVKGGISLKKYFADQALSIFIMPPSIEELERRLISRATDDADTIATRVEKAAEEMTYVNQFDVTVVNTDLDEAKKETEQIIKQFIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A7</accession>
    <name>C6X0A7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GEVED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781939.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00325"/>
    <dbReference type="EnsemblBacteria" id="ACU06792">
        <property type="protein sequence ID" value="ACU06792"/>
        <property type="gene ID" value="FIC_00325"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00325"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256704_0_0_10"/>
    <dbReference type="OMA" id="NIWVDWN"/>
    <dbReference type="OrthoDB" id="1061444at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972165" description="GEVED domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="GEVED" evidence="2">
        <location>
            <begin position="325"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1365" mass="142918" checksum="F4CCE588E796F623" modified="2009-09-22" version="1">MNKKRHFMMKTALALFMVLCSVWGWGQAALPLSRTTWTGAEPTGWTQNQTTDRTSSGACSGSNALIFGTNGAWAQVYFSSTPDKLNFSLKKQSTSGQSKVVAEQSSDGAAWTIIGEYGTATGSTAITDCGNIQVSLLSTTRYIRWTYTKATGNIDMDDVSISAGAEAVCNEGALTAGTTTATTTQVAPGGSSSLSLTGASTGTGLSYQWQSSPDGSSWSNISNAPNATYNATNITASTYYRAALTCGSTTVYSTSVYIDVSYCPAGATNTAYEKIANFSFININNPSTSTAGYENFTAINTDASVGSHPFSIAISDVDASDQILIWIDLDQNNTFDNSELVHQGSILDGSNSTVSGTITIPSSATQGSTRLRIRLHYTSSPGSNNTSCGDSSYGQVEDYTINILPSSPTIIVDGSSLAAFTYTEGNGPSGEQSFGVTGNNLTNNITATAPNNWVVSATAGSGYNTTATLPAAGGTVYIRLAAGLAVNPSYTGNIVLTSTGATSATFAVSGSVTAPITAQSNDTNFGTVTVTGNVITATPSAEYTYADPAYTILSGDAAVTQNGNEFTVTASSATTVQINFAAKPTYTLSLLNDGVVYSDATYPYVTYEGNTVVLPTLANCGTSTFAGWDTNSATSSVPTYAGGANYTTTASNVTLFAVYSETVGAPEQWTKVSALGDIVAGTYVILNGDYYLPNTNTTAAAPPAQITLGSKGVNVSGNILTGTITSDMRWIFTGTNTSMAVVSAANSADKLYNINNNNGVRVHTTDASWVFETHATTTPAYSGFAMKHNNRYCAVYSGGEDWRSYQTKNAANYGTNGGVLDIFKKSGGSTTIYTTSPNCAPAIITWNGSAWSNTTGPDASTQAVIDADYAGPEFAAQSLIVNAGATLTVSNYVTTGDVTNNGHIIVADGANFVQTGTFTPGTDSSFKVRKSTKAVKRLAYVNWSSPMNNSAQTLKQFSYGKKTDGTNQSGTGTVDNRFFTYNNNAFVSILPGSTFNPAGAGFLIRTPNDFTTTGQVFNGQFEGTTPNSGTISYDHSGIGGDYVMLGNPYPSAISLDDFLTANPGTTETVYIWNSQAEMDANNQYTGTNYNTYAPGTGSVPVGSIDGYIPVGQAFFVERATIPTTTPFVFTNALRQTTQDGVFTRGATADKFWLELTSPSGSKPQMLIGFNAAARAWFDAGFDAALIGSNADALYSTVDSRKLVIDAHSSFTADDSFALNADISAAGSYTIGVLKTEGVFANGQQIWLKDQVTGSVTLISEQPYTFTAEAGTVADRFTLQFKPGGALATDGAVKAGITIFSSGSEIHARAAEHISSVEVYEMSGKLIANSKTSQKEITMHVPYKGVVLVKVVLQNGTVQTKKLMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C7</accession>
    <name>C6X0C7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Capsular polysaccharide biosynthesis glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781959.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00345"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06812">
        <property type="protein sequence ID" value="ACU06812"/>
        <property type="gene ID" value="FIC_00345"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00345"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_8_0_10"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="29"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="188"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="378" mass="42886" checksum="5A08497DCA0B17D9" modified="2009-09-22" version="1">MKKKFFLLTTVPISLRFFKGQIAAINNLYEVTLISSPDGSLEEIALEEKVYHKGIEMKRDISVFSDLYSFFKLLLYFYREAPHIIHCNTPKASLLGLIAGFIVRVPTRIYYIHGLRYEGATGLKQIMLKSMERLSCFCATHIVAVSEGVKTTAAADLTQKHISIIHNGSANGMMIDSFTESTYDLTSIKEELKLGKHDFVFGFVGRLVADKGINELVAAFARLSIKYPTAKLLLVGYYEDALDPLQQITKETIKNNPNILECGFQRDVKKYISVMDIFVSPSYREGFGLTLLEANLMGKPVIATRITGYSEIVVEGVNGFLINKKDVSQLQSRMDYVFNHREEIELMRENCLNIVRSKYNHDDVKKSAIKFYRQFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F1</accession>
    <name>C6X0F1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781984.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00370"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06837">
        <property type="protein sequence ID" value="ACU06837"/>
        <property type="gene ID" value="FIC_00370"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00370"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_10"/>
    <dbReference type="OMA" id="SSRYEGW"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="367" mass="41744" checksum="D89AF5FA9FAB9B61" modified="2009-09-22" version="1">MKILYLTDQLYLHGGIEKVLSQKANYFADVSGDEVTLVTYQQKDRKPVYRPSEEIRLLDLNINYETAKSYFHPVNLQKVPAHIAALKRVFRDLKPDVIVSSSFGPDFYFLPYINGNIPVIKEFHSSRALHSRPRSVKERILSALARNAEKKYTGLVVLNPDEAQYYHSGAVSVIPNPAEITDDRGPLIHKKILAAGRISPVKNFGDLIQAFAQLSADFPDWQLHFWGEDYIGTQAKLQSQIDCLALADRICFMGVTDNLKARMQKYSIYAMTSETECFPMVLLESLSAGLPVVSYDSLTGPRHIIKDGEDGFIAPHKNLDIFTEKLRLLMRDENLRQQMGSKGRINVQRFSIDKVMQQWKDLFNSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G7</accession>
    <name>C6X0G7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized secreted protein of SCO1/SenC/PrrC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00386"/>
    <dbReference type="EnsemblBacteria" id="ACU06853">
        <property type="protein sequence ID" value="ACU06853"/>
        <property type="gene ID" value="FIC_00386"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00386"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_4_1_10"/>
    <dbReference type="OMA" id="CPRLVAD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="200" mass="22712" checksum="68EC448F1D11FA67" modified="2009-09-22" version="1">MCQRFKNYFKMKNLMLIFFSLVMIFSCKENDTKPVKDEEHGNSIFLLDSKWQNQDAKELQLKDLKGKNLVVVMIFTSCQTACPLLVADMKRVESKIDKNVLKNTSLVLVSIDPENDTPAVLKKFAQKENIDREPYTFLRGDLESTRELANVLAVKYKEITPIVFSHSNIISVFDKNGEMVSQAEGTIKAEAIAKAVNALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I3</accession>
    <name>C6X0I3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782016.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00402"/>
    <dbReference type="EnsemblBacteria" id="ACU06869">
        <property type="protein sequence ID" value="ACU06869"/>
        <property type="gene ID" value="FIC_00402"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00402"/>
    <dbReference type="eggNOG" id="COG1528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065681_1_2_10"/>
    <dbReference type="OMA" id="CEDKGFE"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="168" mass="19225" checksum="D4298A7BCF23D5EE" modified="2009-09-22" version="1">MISPKITQLINSQIANEQYAAQYYLSMSAWFYAKDLDGIANYFRVQSKEEMMHADKMFDYLVDVGAEIVVGEIAKPPHEFGDAKEIFERAFEHEKIVTKSIFNILKNANDEGDFATVSFLQWFVNEQVEEEANASQLVTKIKMVSENPSALYLFDQELGKRVFTEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L5</accession>
    <name>C6X0L5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/lipase/thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782048.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00439"/>
    <dbReference type="EnsemblBacteria" id="ACU06901">
        <property type="protein sequence ID" value="ACU06901"/>
        <property type="gene ID" value="FIC_00439"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00439"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086603_0_0_10"/>
    <dbReference type="OMA" id="VKFNFSH"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="86"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="288" mass="32868" checksum="1E755E1FEFC7BDBD" modified="2009-09-22" version="1">MKIQIKKNIIIRNAETRDFLADAYFKDSSKKLPLVIFAHGYKGYKDWGAWDLMAEKFAQEGFFFVKFNFSHNGTTLDKPTKFADLEAFANNNFTKEMSDYDALINHFSSSLEVDSNRIAVIGHSRGAGISVIKSFEDDRIKAVVSLAGVSHFGYRFPSGDRLQHWQDTGVMYSENARTKQQMPHYYQFFEDYKANEQRFSVQHAAQHLEKPMLIIQGTDDAAVKDKEAFLLNEWCKSSELFIMEGANHTFGATEPWSSGHLPDDLQRATDKMTAFLDGVFKLNQKNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P6</accession>
    <name>C6X0P6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00470"/>
    <dbReference type="EnsemblBacteria" id="ACU06932">
        <property type="protein sequence ID" value="ACU06932"/>
        <property type="gene ID" value="FIC_00470"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00470"/>
    <dbReference type="eggNOG" id="ENOG502ZWZ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121855_0_0_10"/>
    <dbReference type="OMA" id="ICTIGCS"/>
    <dbReference type="OrthoDB" id="1703910at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973448" evidence="1">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="192" mass="21391" checksum="84C96565831DFC4E" modified="2009-09-22" version="1">MKNFCFFAVCVGALVLLSACHSMQAQSGSALKSVKNQTVIYFNPTVFPDIEEIREPTYSAFFTAVTERVARNRNYKMMKIDDLLSYDSVDAPSLKQYCAHNNAAFAVVPKVKYFKVGFGKYVFSNQVVVSLKLYDAHGRLVAESDYDTYKKKARMLGSAENSIKIGTEGAMKLLGKTLRQSKVSAISFSENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0T9</accession>
    <name>C6X0T9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806337.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01606"/>
    <dbReference type="EnsemblBacteria" id="ACU08052">
        <property type="protein sequence ID" value="ACU08052"/>
        <property type="gene ID" value="FIC_01606"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01606"/>
    <dbReference type="HOGENOM" id="CLU_2553262_0_0_10"/>
    <dbReference type="OrthoDB" id="2092950at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="82" mass="9898" checksum="900210F351892CD7" modified="2009-09-22" version="1">MVNNMEPIKTEIADWLKSLEDETVLLEILKIKNRLEIPRVSEERTAYSIKDDFDERFAQGLTMEESRKRTREFIEKLPWKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0V2</accession>
    <name>C6X0V2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806350.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01620"/>
    <dbReference type="EnsemblBacteria" id="ACU08065">
        <property type="protein sequence ID" value="ACU08065"/>
        <property type="gene ID" value="FIC_01620"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01620"/>
    <dbReference type="HOGENOM" id="CLU_1989349_0_0_10"/>
    <dbReference type="OrthoDB" id="1814058at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970523" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="13826" checksum="C7815D0A9EFC3B84" modified="2009-09-22" version="1">MMKFYLVLAFLGLPISYAIAQKLPSETKNATTRIFPTYAKVYSAPAQDASVNDSLASNRVVQISVDEEQTAADWFSVSYQAGKQKKKGYVRADALAFAMAESGNFQVLFGKYYVKNRKQPIAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0V7</accession>
    <name>C6X0V7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08070">
        <property type="protein sequence ID" value="ACU08070"/>
        <property type="gene ID" value="FIC_01625"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01625"/>
    <dbReference type="HOGENOM" id="CLU_3373899_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="34" mass="4297" checksum="155F3CE48BA4A3BE" modified="2009-09-22" version="1">MTEITHHLFVRERMNIFFEVLKNNRLQIFKFDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0V9</accession>
    <name>C6X0V9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01627"/>
    <dbReference type="EnsemblBacteria" id="ACU08072">
        <property type="protein sequence ID" value="ACU08072"/>
        <property type="gene ID" value="FIC_01627"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01627"/>
    <dbReference type="eggNOG" id="ENOG5030JFA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046825_3_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022134">
        <property type="entry name" value="DUF3667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12412">
        <property type="entry name" value="DUF3667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="27742" checksum="6071704A456502E5" modified="2009-09-22" version="1">MHEVPHSIFHVDNGILFTLKELFTRPGHSIREYLEGKRQQHFKPVMLVLIMGSLCALTQYLLNGKPKAETEVFKGDISGTNITKYIDFNGFISYFRHIVDWLGSHLAFTVLLMLPIAAFGFYLGFRKYKLNYPEWFVIFLFLAGQSLTVYILFIFLNRFAGDFNPLFFFVCFGLVIFSLLQFFEERGRKYVILRALWATVLSYIFILIYLLFSIIIVAAIGLMMYGYGNIITELQNGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X4</accession>
    <name>C6X0X4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806372.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01642"/>
    <dbReference type="EnsemblBacteria" id="ACU08087">
        <property type="protein sequence ID" value="ACU08087"/>
        <property type="gene ID" value="FIC_01642"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01642"/>
    <dbReference type="eggNOG" id="COG0116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032119_3_0_10"/>
    <dbReference type="OMA" id="GFMYKAN"/>
    <dbReference type="OrthoDB" id="1772619at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="389" mass="45344" checksum="75B8DC6A883F89A9" modified="2009-09-22" version="1">MDTDNLKIQIKTFFGLEEILAEEIRKLGGANVEIKNRAVNCEGDLGFLYKINYSARTALKILIPVLTFKAWDESRFYDKLFDFPWDDYMSVDQTFAIDATVYSERFKHSQFMSQKMKDAIVDYFKFKHRKRPDVNTIDPDIKFHLHIDRELVTISMDSAGDALFKRGYRKEQGEAPINEVLASGMLQLAGWDGKGNFLDPMCGSGTLLIEAAMIAMDLPAQIFRKKFAFQNWKNYDEELFQKIKEVRINRVKEFTGKIVGYDVDSQMLNAVHLNIEAAEMEDVIEVKNQDFFESKKELFPLLMVFNPPYDERIEIEDDEFYKKIGDTFKKNYPNTLAWFISSDLDAAKKVGLRPSRRIKLYNGKLECRFLQFEMYEGTKKTHKLTNEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X8</accession>
    <name>C6X0X8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactoylglutathione lyase and related lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01647"/>
    <dbReference type="EnsemblBacteria" id="ACU08091">
        <property type="protein sequence ID" value="ACU08091"/>
        <property type="gene ID" value="FIC_01647"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01647"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_10"/>
    <dbReference type="OMA" id="IHHICYE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="60"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="190" mass="21069" checksum="516E9443F073CCE7" modified="2009-09-22" version="1">MELFGRVLFSPAPGGSRKKDRSACSRFFRGGGFAVVPKKSSNNALRPHAGHFIKTKLFMKIEHIGIAVKSLQTSDNLFERLLGKKNYKQESVAREGVTTSFYETGDSKIELVEASNAESPIAKFIDKKGEGIHHIAFGVDDIAYEIERLKKEGFIFISEEPIDGADNKLVVFLHPKSTNGVLVELCQEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X144</accession>
    <name>C6X144_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806442.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01714"/>
    <dbReference type="EnsemblBacteria" id="ACU08157">
        <property type="protein sequence ID" value="ACU08157"/>
        <property type="gene ID" value="FIC_01714"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01714"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_1_0_10"/>
    <dbReference type="OMA" id="MWQLNAD"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="272" mass="31559" checksum="448B1BBADA1E2673" modified="2009-09-22" version="1">MISEHSDEHLETILSDVLEIYGYDFTGYSRASLKRRIVRLYELDKFVSFAEYRYKIRTEPSYFKRFLQQVTINVTEMFRDPAFYSTLRTEILPRLGTYPFIRIWVAGCSTGEEAYSIAIFLKELNLLHKSLIYATDINSAVLENAAQAIIPMSKLQLYTENYIAAGGSEQFSDYYTANYSLGKLNNELKSKIIFSGHNLVTDNSFNEFQLILCRNVIIYFDRPLQNKVFGLFDNSLEKFGYLALGTKESLDFSPVAKNFERLPAAKIWRKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X151</accession>
    <name>C6X151_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium chelatase, ChlI subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01721"/>
    <dbReference type="EnsemblBacteria" id="ACU08164">
        <property type="protein sequence ID" value="ACU08164"/>
        <property type="gene ID" value="FIC_01721"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01721"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043779_0_0_10"/>
    <dbReference type="OMA" id="GMIPRAN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="497" mass="56170" checksum="689B23093D3318C9" modified="2009-09-22" version="1">MPIIKHPSPNNKYMKNDTTIKELKNSGYTHKTINKEIQTKLITKIKAKEPVFEGLWGYEDTVVPQLKKAILAGHHINLLGLRGQAKTRIARSMVSLLDEYMPIVKGSEINDSPFQPISKFARDLVAEHGDDTPISWVHRSDRFFEKLATPDVNVADLIGDIDPIKAATLKLPYSDERVLHYGMIPRANRCIFVLNELPDLQARIQVSLFNILQEGDVQIRGFQLRMPLDIQFLFTANPEDYTNRGSIVTPLKDRIGSQIFTHYPKTVALARQITEQEALVSEDDKAHITVPGLAKDLLEEVAFAARESEYVDAKSGVSARLTISAMENLMAAAKLRLIESGVEQTTVRLVDFMSIIPSITGKIELVYEGEQEGADHVAKLLIDQAVMVQFEQLFPRIPKLEKEGIKTPYTDLIKWFDQNAVELNYDDSDEEFYSKLESITPLSSIVEENVEHMSAEDKKFCKELILWALTIGKKLDRTENQNAYTFDSAGIGKYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X175</accession>
    <name>C6X175_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical Nudix-like regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806473.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01745"/>
    <dbReference type="EnsemblBacteria" id="ACU08188">
        <property type="protein sequence ID" value="ACU08188"/>
        <property type="gene ID" value="FIC_01745"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01745"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_3_1_10"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="AraR_C" evidence="2">
        <location>
            <begin position="166"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="241" mass="28431" checksum="B4A9ED9F1C7DA0CD" modified="2009-09-22" version="1">MSPDFIHTYVSVDCVVFGFNHENRLNVLLVQRRIDEEVIERPKKLPGSLILNNEDVDDAAERVLFELTGIKKMVLKQFKCYADPNRASNKDDIKWMGDEYKHNIDRIITVAYLSLCKIDHKINTTKYDTADWYPVDQVPLLPFDHNQIISESLVEIRKWIESDFSIIFQLLPKRFTIRQLYQLYSAISEKKIDIKNFHKKISSFSYIIPLDEIETNVAHRAARFYKFDPKVFKKSNNKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X197</accession>
    <name>C6X197_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton/glutamate symporter family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01767"/>
    <dbReference type="EnsemblBacteria" id="ACU08210">
        <property type="protein sequence ID" value="ACU08210"/>
        <property type="gene ID" value="FIC_01767"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01767"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_2_10"/>
    <dbReference type="OMA" id="YFAYQVG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="421" mass="45697" checksum="613DF562DC8D7285" modified="2009-09-22" version="1">MLLRKKNYICIRLIFDHMKNLINNYSAIFLLLMGIAVGSLIGIFAPEAVIYLKPLGDIFLNLLFVSVVPLVFFAVANSIASLEKQSKFGKIIFTMAGTFLLFILISAVFTVIVVYLFPTEALPSTADETLEANNPVSWSDRLVSFFTVSEFTELFSRKNMLALLIFAFLTGTAVRKAGEAGSSFKEFLASGFEVMKELLLIVMKAAPIGLGAYFAYQVATVGPQLFGFYAKPLGLYYAAGTVYFFAFFTLYAFMAKGKNGISQFWRNNIYPSLTAVSTCSSFATMPANLQAASRIGVPAAIANIVIPIGSTLHKQGSSMSSIIKIYVAFLIIGEDFFDPMNLLLALGITVFVSIVAGGIPNGGYIGEMLMISVYQLPIEAIPAVMILGTLVDPLATILNSTGDTVAAMFVTRISGEKFVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D9</accession>
    <name>C6X1D9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806537.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01809"/>
    <dbReference type="EnsemblBacteria" id="ACU08252">
        <property type="protein sequence ID" value="ACU08252"/>
        <property type="gene ID" value="FIC_01809"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01809"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_3_1_10"/>
    <dbReference type="OMA" id="IRCPVWA"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973583" evidence="1">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="58"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="278" mass="30644" checksum="5DE2F1486B218B33" modified="2009-09-22" version="1">MKLPFFTIAVSILLLATSCKDKAAPVPQNAGSAESVSGNIKTEELTTEINGVTHRSFAAYNADIDGQLPVVFVLPEWWGLTDYVKGRVKQLADLGYYAVAVDYYGDAKVVETPEEAQQLSSHFYSIPVDARRMFDATKHQVILAEKADYSRMAIIGYCFGGSQALNMGRLSGDFKGVVSFHGNLKTGIRAKNNKVKYLVLNGAADSMVSKNEIAAFRKEMDSAKITYKLIDYPNALHAFTNPAATETGKKFNIPIAYNKEADEKSWNEMKTFLAEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F1</accession>
    <name>C6X1F1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01821"/>
    <dbReference type="EnsemblBacteria" id="ACU08264">
        <property type="protein sequence ID" value="ACU08264"/>
        <property type="gene ID" value="FIC_01821"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01821"/>
    <dbReference type="eggNOG" id="ENOG5031375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381978_0_0_10"/>
    <dbReference type="OMA" id="YYRIEYL"/>
    <dbReference type="OrthoDB" id="1748117at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="218" mass="25477" checksum="37C63DCA727F1A6B" modified="2009-09-22" version="1">MRLCFRRNAVLREIFNYLYGMFYLFILLFILLSAALLATIFESGKPGLWSRIFRIAVVVFATGIFSYYFVTRSLTQFRKDSLTVQLINKLPFPLDFYIVKVQTGKDSAPTYETSHPGDIRSGYYRIEYLDMTDSDEFWIAGFMGNKNMVYFSQHAVPNKNEDQIIEIQNYINQSQKLSETAATQIESLKFGNMKTAIWMTLDLLLLFLNITLLIRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G1</accession>
    <name>C6X1G1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="5" type="ordered locus">FIC_01831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01831"/>
    <dbReference type="EnsemblBacteria" id="ACU08274">
        <property type="protein sequence ID" value="ACU08274"/>
        <property type="gene ID" value="FIC_01831"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01831"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_0_0_10"/>
    <dbReference type="OMA" id="SAVKWLN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="258" mass="27328" checksum="CCB6BAEF99BF6771" modified="2009-09-22" version="1">MSVKIRLQRHGKKGKPFFHIVVADARARRDGKFIEKIGTYNPVSNPAVIELNVDSAVKWLNNGAQPTDTARAILSYKGVLYKKHLLGGVAKGAFDEAEAEKRFSAWLENKEQQVLGKKDNLNKAKDDAKKAALEAEAKVNQARLDAAAKVEADAKAEAEAKLAEEKAAADAKAAEEKAAADAKLAEEEAAKAPEAEATEDTAKSAVENVAESLGNVAAAVSGVVDAVKETVADVTEKIADAVAPKTEETPEAEDEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G9</accession>
    <name>C6X1G9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806567.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01839"/>
    <dbReference type="EnsemblBacteria" id="ACU08282">
        <property type="protein sequence ID" value="ACU08282"/>
        <property type="gene ID" value="FIC_01839"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01839"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058239_1_0_10"/>
    <dbReference type="OMA" id="PFRTYVG"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19580">
        <property type="entry name" value="Exo_endo_phos_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="314" mass="35892" checksum="E88EBF2CCFDFDA19" modified="2009-09-22" version="1">MENNGSKEIIAFYNVENLLMPDPPPVHKTDPSASGLRNWDERKYRIKLSKIAHVFQLIADQEGVTPLLIGLCEVQGREPLEELLALTPFPNHQIVHYGSSDLRGIDVALLYDRTKLQLISSQPLSFNFQTTDGESQPDPTRDILHCRFHCDGRNLNVFVLHLPSKREKDVNKALRTNILEQLHQVVTEYIANGEAVIICGDFNANPDEDTVKKLLYDKDFMKVLHNPFGELLSANKFSTYHRANGLLFDQIILSDGFYRTGFPLKFKTAKIFSYEKLRVRDRKLAARPAKTFAGTRYLGGYSDHFPVITEFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S0</accession>
    <name>C6X1S0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806668.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01941"/>
    <dbReference type="EnsemblBacteria" id="ACU08383">
        <property type="protein sequence ID" value="ACU08383"/>
        <property type="gene ID" value="FIC_01941"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01941"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042154_0_0_10"/>
    <dbReference type="OMA" id="KFTIMAL"/>
    <dbReference type="OrthoDB" id="1661399at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13125">
        <property type="entry name" value="MATE_like_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044550">
        <property type="entry name" value="WzxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="426" mass="48559" checksum="A1FC6FB019B1C944" modified="2009-09-22" version="1">MINKIKGVIASDLIKVFSFTGLSTFIKLITSYITIKVVASVIGPSGIALIGQLNNFTSIFTTLGAGGINNGVVKYVAEYKDDETELQKFLRNGFKITLLFSVFFGGVLVVLASFFSQLILLDQQYSYVFLFFGVSLILMSFNNYFLSILNGFKEFKKFVVINIITSIVGLLFTVTLVFLFQLKGALIATVSYQSVILFVTFFFLRESPWFDSIMFWGRLNMDVVKKYLSYSLMALVSAASVPVSQLFVRAYIIKSHSVTSAGYWEGMNRISGLYLLFVTTSFSVYYLPKLSEIKTNILLRNEIVKTYKVITPIIAGSLILIFLLKNLVINILFTKEFYPMKDFFFWQLLGDFFKIMSWILAFVMIAKSMIKYYIITEIVFSALFVGLSILFINYQGVIGVTQSYCLNYFMYFLIMLFLFRKLLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U0</accession>
    <name>C6X1U0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="8" type="ordered locus">FIC_01961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806688.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01961"/>
    <dbReference type="EnsemblBacteria" id="ACU08403">
        <property type="protein sequence ID" value="ACU08403"/>
        <property type="gene ID" value="FIC_01961"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01961"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_10"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="128" mass="14382" checksum="372A689AAE393A3B" modified="2009-09-22" version="1">MSTVHKIGRRKTSVARVYVKPGSGVITINKKDSKDYFGTDVLVYKLNQPFLLTETAGQYDVTVNVFGGGITGQAEAIRLAVSRALCEINAEFRLLLKPHGLLTRDARMVERKKPGQKKARKRFQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B8</accession>
    <name>C6X2B8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ordered locus">FIC_02145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806865.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02145"/>
    <dbReference type="EnsemblBacteria" id="ACU08581">
        <property type="protein sequence ID" value="ACU08581"/>
        <property type="gene ID" value="FIC_02145"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02145"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_10"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="3"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="365"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="503" mass="57531" checksum="A5BA84C46E0B3C95" modified="2009-09-22" version="1">MTKVRVRFAPSPTGPLHLGGVRTALYDYLFAKRQGGDFVVRIEDTDTARYVEGAEEYIMEALEWCGMIPDESPKHGGRYGPYRQSERRDIYDRYLEQMLKTDYAYLAFDTTEELDEIRKSYEEKGDVFAYNYITRNHLKNSLTLSAEEVQQLISDEVPYVVRFKMPVDRILNLEDIIRGKFAVNTNTLDDKVLVKQDGMPTYHFANIIDDHEMEISHVIRGEEWLPSLGLHYLLYEAMGWEKPQFAHLSLILKPEGKGKLSKRDGDKFGFPVFPLNFKDPETGTVSRGYREDGYLPEAFINMVALLGWSPANDREILSLEEMAAEFDLNKVHKAGARFNKEKAEWFNHEYLKLKSSEEVLPLLKQVEGITLNNCSDEKLLTVISLMKDRAVFVKDIYNDGIFFFEAPTVYDEKALKKAWNADAARIMNDLAVELENVDQFDAENLKSSIHTFAEGKSLGMGKVMMPLRLCLVGELKGPDVPDILQVLGKAECVSRIRNAVNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F7</accession>
    <name>C6X2F7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ordered locus">FIC_02184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806904.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02184"/>
    <dbReference type="EnsemblBacteria" id="ACU08620">
        <property type="protein sequence ID" value="ACU08620"/>
        <property type="gene ID" value="FIC_02184"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02184"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_10"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="158" mass="18056" checksum="FA5CE729135FF340" modified="2009-09-22" version="1">MRIAVFPGSFDPITLGHFDIVERAAPLFDKIIIAIGQNSQKKYMFSLEQRIEFIKKTFEKFPNVEVDHFEGLTIDYCRSKNVNFILRGLRNPADFEFEKAIAQTNRELTQSNKVETIFLLTSASKSFISSSIVREIITFGGNYELLVPDTVRVNVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L4</accession>
    <name>C6X2L4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02244"/>
    <dbReference type="EnsemblBacteria" id="ACU08677">
        <property type="protein sequence ID" value="ACU08677"/>
        <property type="gene ID" value="FIC_02244"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02244"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017617_1_1_10"/>
    <dbReference type="OMA" id="NTWANKS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_3" evidence="1">
        <location>
            <begin position="197"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="664" mass="75233" checksum="0CC5572A6B8F2D3D" modified="2009-09-22" version="1">MDAESLVQFLKNTPAENIQKIEIITMPGSEFQVDASDGIINIILKKRSTDGLNGNMRMAGSVNKYSQNTASFSANYRKDKLGISANLSGGSNIQAQSYVLRNGNGLVSNESVGDIDDPNQNIGGYVNIDYQLTDKSSLAFSWNTWANKSYDSQVNLFNTLRKFDADGNLTGISFSNSRNVEDARSYNNNFNLNYELKTDSLGSKLNLNAAYLNYKRLQNTDNNTFAALADGSDSFLTRYVYQSLPQLINNFSVTADYIQKFDIDFSVAVGGNFNKTNTDNDTQNTTYDYLYNPEGTLIDTDMSPTPNHFIYDESIYGFYLTLEKKVSEKFSGKVGARYEITNSLGTSDNLPDISLRRIERNYSNFLPYVSLNYALNDKNNISYAFSSRMRRPSFGMINPVKNILTENNYTQNNPFVKASSTYNQELTYMYKNSYFLILNHSFLKDVITQVPLQGFPVSPDGTVGPENQLRYIRTNFGDRQEMAAMLGLNKSFFKQALSINFNAGVQHNINNGSLAVDPTTGDRFQNILGEFVTYSNNTSSTSFVIQTNNTLRLDKKKTWFLGVNYFYVDKQQIELGLLNELMSLDLNIKKIWNDWTFTFSVNDVLRTNVVEIEDIQQNGNYNYVKNDMYRQNAALSIVYNFGNKKVKKVREIDDANSDVKSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N7</accession>
    <name>C6X2N7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806984.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02267"/>
    <dbReference type="EnsemblBacteria" id="ACU08700">
        <property type="protein sequence ID" value="ACU08700"/>
        <property type="gene ID" value="FIC_02267"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02267"/>
    <dbReference type="eggNOG" id="COG2096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083486_0_2_10"/>
    <dbReference type="OMA" id="VSYCHIA"/>
    <dbReference type="OrthoDB" id="1401910at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="189" mass="21373" checksum="341B744EF5807429" modified="2009-09-22" version="1">MKIYTKTGDSGETALYGGTRVSKASARVEAYGNIDELNSFIGFAKAEISDDLVLTQLKKIQFDLFTVGSESATPTDKLTLANGKSRLSLMISETEIEELENWMDAFENELEPLQYFILPGGGKGATSLHICRTVCRRAERSLVYLNESEEVRPELIKYLNRLSDYLFVLARYVSKFNGDTEEYWNPNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P2</accession>
    <name>C6X2P2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical Cytosolic Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806989.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02272"/>
    <dbReference type="EnsemblBacteria" id="ACU08705">
        <property type="protein sequence ID" value="ACU08705"/>
        <property type="gene ID" value="FIC_02272"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02272"/>
    <dbReference type="eggNOG" id="ENOG502Z8S7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091303_1_0_10"/>
    <dbReference type="OMA" id="GNVAVFW"/>
    <dbReference type="OrthoDB" id="1060869at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025335">
        <property type="entry name" value="DUF4241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14025">
        <property type="entry name" value="DUF4241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="212" mass="23617" checksum="B35692C1293112BC" modified="2009-09-22" version="1">MTHLKNIAKLFTKNFVESPLIETFEAGKISITSGRLVACDPVLTNDMEPFSTVFPSGEFQVLVHKERESNCIAYVEIVFGNSSVSRWDLATTGDQKTEDLKGEEIFGYPVESGMGCFMDLQTQTSLDRLEQELFAKKGADFMGIYEEFFHSYFFDENGAIDQFASLKPDENAPGNIFAFETGYGEGFYGSYIGFDADGKPVKVVTEFIEIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T6</accession>
    <name>C6X2T6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02316"/>
    <dbReference type="EnsemblBacteria" id="ACU08749">
        <property type="protein sequence ID" value="ACU08749"/>
        <property type="gene ID" value="FIC_02316"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02316"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OMA" id="SIYDYWL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973507" evidence="5">
        <location>
            <begin position="26"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="346"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="976" mass="107765" checksum="79A5CD0DE5EC5140" modified="2009-09-22" version="1">MLIMNVKLRVLSMGALFFAAHNLSAQTDSTKVQEIDEVVVVAYGTQKKSTLTGANVQIGAKEIEDRPLSNALQALDGAGAGIQIAAGSGQPGSAPTIRIRGAGSFLASNEPLIVVDGIPFPGDLGSINPNDIESLNILKDASSTSLYGSSAANGVILVTTKRGKKNSSRITLNSSTGIISRFVEEYDRVGPADYYGLTWEAMRNGRLLQPNQTLATANAYASANLISGNLKTNVFNVPDNQLVVDGVFNPNAQLKYHDFDWADALMGVGIRNDHNISYSGGNDKSSFFSSFNYLKEEGYLAKSDFERISLRLNTDSQVKSWLKLGTSLNGSVSSGSNAVDGVENNASFNNPFRWTRGIGPIYSPYQYNQAGQRMYGPNGEVLYDAGANRGPDAASGRNVVWETLLNDDVTNAYNIQANVFAEFQILPELTFRTNGAYNFRGTLRKEYTNTEIGDAIGIGSATRTAYFRRDFTWNQVLTYNKAFGNHNFTALAGHENIDYKYDYLYGYKRNQILEDFYEFDNFVNNSSLSSALNRRSKEGWFGRVNYDFNEKYLLEGSIRWDGSSRFAEDVRWQSFWSAGAGWVISRENFMSNIEAVNFLKLRGSYGEVGNDNLGSWYPYQSVYGLGTNNGFEPGTILSRVADRTISWETKAQSDVALEFELFSRRVKGTLEYYNSETRDLLFATKTPLNAGIPNNEIETNIGNLVNRGYEITVSADVIKNQNVKWNITAFGSSYKNEVTKLEASFINGSKRIELGRDLYAFYLRTWAGVDPADGQALFVMDPTKATVNPTDERTVNGRAVTTNLNKALLEYQGSAIPDFFGNFATTLNVKNWELSAAFNYQFGGLIYDTNYAALMTAYPQGGALSTDILNRWTAPGQITDVPVLNSSYIAAPAAASARWLVDASYVMLRNATLGYNFDKEITRTVGVNSLKLFVSGENLWLTSKRKGLEPYQSFNGTTSNRYSPARIITFGLNTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X310</accession>
    <name>C6X310_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02390"/>
    <dbReference type="EnsemblBacteria" id="ACU08823">
        <property type="protein sequence ID" value="ACU08823"/>
        <property type="gene ID" value="FIC_02390"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02390"/>
    <dbReference type="eggNOG" id="ENOG5033HUU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186749_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="92" mass="9752" checksum="CA6FC5F1209C372C" modified="2009-09-22" version="1">MSTKRNGLLALLGLGAVAWWKYKNSTPEEKQAVKDTLSNAKDNFNKFGSDLKSKATDVASQVQNKVATATNNGSTSGDNGAGQPDTQNQSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X337</accession>
    <name>C6X337_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin oxidoreductase, iron-sulfur binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807134.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02417"/>
    <dbReference type="EnsemblBacteria" id="ACU08850">
        <property type="protein sequence ID" value="ACU08850"/>
        <property type="gene ID" value="FIC_02417"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02417"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306470_0_0_10"/>
    <dbReference type="OMA" id="SRDMHWL"/>
    <dbReference type="OrthoDB" id="178823at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030948">
        <property type="entry name" value="MoCo_extend_TAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04519">
        <property type="entry name" value="MoCo_extend_TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="749"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="847"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="879"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113426" checksum="364A3D25A36F6186" modified="2009-09-22" version="1">MASNKIQFRSIHELKDPGLNAKLAQKEFQDEIPVGDLLGQKASSESGSSRRDFLKLLGFSTAAVTLAACEAPVIKSIPYVVKPHEIIPGVPNFYATSYFDGYDFASVLVKTREGRPIKIEPNPAAGELGKTNARAQASILSLYDNDKVKQPKLNGKDETFDQVDDYVLKGLTEAQTNGRRIVVLSHSFPSPTFKKLFADFKTKYPTAELVTYDAVPCTAALDAAEEVFGQRALPVYDLSNTQLVVSFQADFLGEYNGASLEGTYAAARTPGPNMLRHIQIESNMSLTGANADNRIKLKPSAVNKVLVEVYNALNGGTASKEAQAIVQELQAKGSNAVVFADGSKGAHVLAHLINQKLASNAFTGKANFLKEFDARRYQEFVGWMSTGQVAVVIANNVNPLHSSNRAEDFKKALARVPYVIAVADKKNEMYKAAKAVIPVANWLESWGDIAPQTGVYTLMQPTIQKIYKSRQIEESLLVWMNGKNNPANNYYDYLKANAATLIGGTTFNKALYDGVLAGGNSATLSYAGGNAAQAAAELGAFKASDMELVLYTKTAIGDGTQANNPWLQELPDPITRLSWDNYLTISPRDAEKLGIDNDLNARMQLNGSKVNLTANGVTLKDVPVFIQPGQAEGSLGLALGYGKKDSGKVAETGINAYPLFDGSNSVLSNVKIEKTGDYHEFAGMQLQNTLMGRYEIAREVPLDTFLNVKFDDEKLGWNRPLKYETIGGALPAGQVDLWDSFDESDGPHFNMSVDLNSCTGCGACIIACQAENNVPVVGKEEVRMSRDMYWLRIDRYYSTNVPADVDLNKDSKLSQEEAIAADLNVPGMYGHFMDEKSGILNHPADNPDVIFQPVMCQHCNHAPCETVCPVAATSHGRQGQNQMAYNRCIGTRYCANNCPYKVRRFNWFTYNLNDKFDFNQNNDLGRMVLNPDVVVRTRGVMEKCSLCIQMTQRTILEAKKEGRKVRDGEFTTACVNACSTGALKFGDMNDKDAQIRMLFQSDRRYTLLEEIGTKPNVFYHTKVRNRKEQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X350</accession>
    <name>C6X350_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807147.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02430"/>
    <dbReference type="EnsemblBacteria" id="ACU08863">
        <property type="protein sequence ID" value="ACU08863"/>
        <property type="gene ID" value="FIC_02430"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02430"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_1_10"/>
    <dbReference type="OMA" id="NELICLM"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="364" mass="41366" checksum="C94C554B6CE4022F" modified="2009-09-22" version="1">MKIIDLHIIKKYLGTFAFMLGLLTLIVLIIDVQAKAPRIESNGFSVTEFLINFYPYWIVNLIITFMSILVFISVIFFTSRMANNTEIVAIISSGASFHRFARPYLITSSFIAAIALLLNHFVLPLANVKKNELEPYTYTAKSREEYIGNTEVSTQLSKSEYIFIKSYNRKERRGSGFMYQKFDKNRKLTYQIIANEFSWDDKKSHFILNSYLEKTVRKDETEKLGSGDTMTKSFGHPPEELFPGVLLGQNKTTPDLIGFIDREKEKGNANLGNYQNELHQRTSMPVSVIILTFLGLSLASQKKRGGLGMNLAIGISLAFVFVFSFEALKVVSKNQSLPPLLAMWLPNLIFGPVALYLYLKRANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X361</accession>
    <name>C6X361_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02441"/>
    <dbReference type="EnsemblBacteria" id="ACU08874">
        <property type="protein sequence ID" value="ACU08874"/>
        <property type="gene ID" value="FIC_02441"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02441"/>
    <dbReference type="HOGENOM" id="CLU_2990091_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="57" mass="6037" checksum="3DB4878B06D4E450" modified="2009-09-22" version="1">MFFGQSLAAAGAAARAGLSTAIFFGGSGSLRHQKRIYVSIPIAGSRLIYTGRHKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B2</accession>
    <name>C6X3B2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="18" type="ordered locus">FIC_02492</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807209.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02492"/>
    <dbReference type="EnsemblBacteria" id="ACU08925">
        <property type="protein sequence ID" value="ACU08925"/>
        <property type="gene ID" value="FIC_02492"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02492"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_10"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="429"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="628"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ACU08925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="663" mass="75814" checksum="7AA552DCE01671C9" modified="2009-09-22" version="1">MRFQLQSEYKPTGDQPVAIDKLTKGLEIGEKYQTLLGVTGSGKTFTVANVVNNVQKPTLVLAHNKTLAAQLFMEFKEFFPDNAVEYFVSYYDYYQPEAFIASTNTYIEKDLSINEEVEKLRLSASASLLSGRRDVLIVASVSCIYGIGNPSEFNKSLIELKKSSKITRTDFLHKLVNALYSRTLNEFTRGTFRVKGDVIDVYPAYADNAVRVQFFGDEIEKIYSFNPLTGNIMSDFDEMNIYPANLFVTSKETQVGAIREIQDDMVKQVDFFNSIEKPFEAKRLQERTELDLEMMKELGYCSGIENYSRYFDRRLPGTRPFCLLDYFPKDFLMVIDESHVTVPQVHAMYGGDRSRKEVLVEHGFRLPAAMDNRPLKFEEFEAMQNQVIYVSATPADYELEKSGGEYVEQIIRPTGLLDPIIDIRPSINQIDDLIEEIRKRTEVDERVLVTTLTKKMAEELTKYFTRFGIRTRYIHSDVETLERIQIMQDLRVGLFDVLVGVNLLREGLDLPEVSLVAILDADKEGMLRSRRSLVQTIGRAARNVNGRAILYADKITVSMQRAIDETNYRRQKQMEYNEKHGLVPTSLNKKISEILVGRSKDFPDPKYTQKEILKQVAEDKANYGKDAQVLIAEKQKAMEAAARNLDFIKAAKLRDEIAALKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C8</accession>
    <name>C6X3C8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807225.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02511"/>
    <dbReference type="EnsemblBacteria" id="ACU08941">
        <property type="protein sequence ID" value="ACU08941"/>
        <property type="gene ID" value="FIC_02511"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02511"/>
    <dbReference type="eggNOG" id="ENOG5032RN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177544_0_0_10"/>
    <dbReference type="OMA" id="PWPATKE"/>
    <dbReference type="OrthoDB" id="1989621at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="73" mass="8617" checksum="137979FFF7B45880" modified="2009-09-22" version="1">MYWTLELASYLSDAPWPMTKAELIDYAIRTGAPMEVVENLQAIEDEGEIYESIEEVWSDYPTDDDFLWNEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E0</accession>
    <name>C6X3E0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfur acceptor protein SufE for iron-sulfur cluster assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807237.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02523"/>
    <dbReference type="EnsemblBacteria" id="ACU08953">
        <property type="protein sequence ID" value="ACU08953"/>
        <property type="gene ID" value="FIC_02523"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02523"/>
    <dbReference type="eggNOG" id="COG2166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124502_0_0_10"/>
    <dbReference type="OMA" id="DWMQRYE"/>
    <dbReference type="OrthoDB" id="1996347at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="PTHR43597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufE" evidence="2">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="139" mass="15844" checksum="0DF3CCB4A1248394" modified="2009-09-22" version="1">MTIKEKQQEIVEEFAFLEDWEQKYEYIIDLGKELKGLDSARKTDENLIKGCQSQVWIDAEYRDGKLFFNADSDGILPKGIVSLLVSIYSGHSTQEILDSDFAFISEIGLQEFLSPSRANGLMAMTKQIKFYAVAYQLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F6</accession>
    <name>C6X3F6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ordered locus">FIC_02539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807253.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02539"/>
    <dbReference type="EnsemblBacteria" id="ACU08969">
        <property type="protein sequence ID" value="ACU08969"/>
        <property type="gene ID" value="FIC_02539"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02539"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_10"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="598" mass="67155" checksum="511FBE67EBC2411C" modified="2009-09-22" version="1">MKNIRNFCIIAHIDHGKSTLADRLLEYTNTVTSRELQSQTLDDMDIEKERGITIKSHAIQMDYELNGEKFILNLIDTPGHVDFSYEVSRSIAACEGALLIVDAAQSIQAQTISNLYLALENDLTIIPILNKIDLPSANPEEVTDEIMNLIGCDYEDVLRVSGKTGEGVHELLEHIVNRIPAPVGDPDAPLQALVFDSVYNPFRGIEAYFKIVNGSIKKGQRIKFMATGKMYEADEVGTLKLKQAPKKEIMTGDVGYIISGIKDAREVKVGDTITTFENGAEAAIEGFEEVKPMVFAGIYPIEAEDFEELRFSLEKLRLNDASLVFEPESSAALGFGFRCGFLGMLHMEIVQERLDREFNMDVITTVPNVSYHGYTKREPEKMILINNPSEMTDPMTMDRVEEPFIKASIITKSDFVGSVMTLCIEKRGEIVTQNYLTADRVEMVFNMPLAEVVFDFYDRLKSISKGYASFDYHPIGFRASKLVKMDILINGDMVDALSSLIHDSNAYYIGKRMCEKLRELIPRQQFDIAVQAALGAKVIARETIKALRKDVTAKCYGGDISRKRKLLEKQKEGKKKMKQIGRVEVPQSAFMAVLKLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G8</accession>
    <name>C6X3G8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tpl protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807265.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02551"/>
    <dbReference type="EnsemblBacteria" id="ACU08981">
        <property type="protein sequence ID" value="ACU08981"/>
        <property type="gene ID" value="FIC_02551"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02551"/>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033149_0_0_10"/>
    <dbReference type="OMA" id="KLKCCLN"/>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="116"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="428" mass="48560" checksum="E7E4E164AF808380" modified="2009-09-22" version="1">MSCGCKTSGDSSHSCGTKSASGCENVNTCGNSYKLSVFDWLSNISNPSGSQCDFVEVRFKNDRKCFYKNVHNLPLHMGSVVTVESSPGHDIGVVSLTGELVKIQMKKKYFTEDNPLKIYRLANQKDIEVWHDARAREESVKIQARKIAYALNLNMKITDVEYQGDGAKVTFYYTSETRVDFRQLIKEFAATFRTKIDMKQIGFRQEAAKVGGIGSCGRELCCSTWLTDFRSVNTNAARYQQLSINPQKLAGQCGKLKCCLNYELDSYLDALSDFPPSSTTLDTEKGRAFCIKIDVFKKKMWFAYMERSMAWYDLDVADVKTLIAQNKKGEKCSPLEDLQKHDAPVKSVDLIQESSVDRFERKHKDSGNQNRKKQKNNPNHKPGNRADGKPAESRRNPAEKNQPQNQQTGEPRPKKFKKKFQPKRDDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H6</accession>
    <name>C6X3H6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807273.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02559"/>
    <dbReference type="EnsemblBacteria" id="ACU08989">
        <property type="protein sequence ID" value="ACU08989"/>
        <property type="gene ID" value="FIC_02559"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02559"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1509485_0_0_10"/>
    <dbReference type="OMA" id="PFANYYF"/>
    <dbReference type="OrthoDB" id="2018542at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973663" evidence="1">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="178" mass="19713" checksum="BCB9281B99F23901" modified="2009-09-22" version="1">MKNLIVLTFLFAGLFTKAQTESSPQTPNAEQRWTFGGYAGLGGAFGNGGGISVYLSPRVGYKLKEELETGLAANFTWSNSSYHSSTMIGVGPFANYYFSRNFYLSGMFQQYFINQKNKIDNLTYSADESALYLGGGYMQRLGERIYMQIGGMYNVLYDRDKSFLGGGFIPNIGVVYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H9</accession>
    <name>C6X3H9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02562"/>
    <dbReference type="EnsemblBacteria" id="ACU08992">
        <property type="protein sequence ID" value="ACU08992"/>
        <property type="gene ID" value="FIC_02562"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02562"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_10"/>
    <dbReference type="OMA" id="QVEDIAY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="247" mass="29178" checksum="C67C3B4AC2408299" modified="2009-09-22" version="1">MIKTIIIEDEKPAARKLLRLLSLFSELEIVATLHSVEESVAWLQQNEHPDLIFSDIVLGDGLSFDIFEKVPTRSFMIYTTAFDQYTLKAFKLNSIDYLLKPISEEDLRKAVEKHKSFLPSERPHNMQEIKSLIKEEKQKLSRILVKIGYNLKIIQTHEASCFFSENKIVYLQTKERTYPTDFTLDELENLVDESKFFRVNRQFIINSDCIKNIHTSPYYKIELEFQPEMEITVSRDRVKDFKEWLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N8</accession>
    <name>C6X3N8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_C25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782173.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00568"/>
    <dbReference type="EnsemblBacteria" id="ACU07026">
        <property type="protein sequence ID" value="ACU07026"/>
        <property type="gene ID" value="FIC_00568"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00568"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004870_0_0_10"/>
    <dbReference type="OMA" id="VLNYPNP"/>
    <dbReference type="OrthoDB" id="110780at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001769">
        <property type="entry name" value="Gingipain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029031">
        <property type="entry name" value="Gingipain_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01364">
        <property type="entry name" value="Peptidase_C25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970630" description="Peptidase_C25 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C25" evidence="3">
        <location>
            <begin position="546"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1302" mass="145207" checksum="E172B50FAFE54ABD" modified="2009-09-22" version="1">MIRIYTVILFFFISSIASAQTFRLEWEGTETIDFGTYKVTVPAIKNEGFAYEEGSVFFRSTQKYAGTDMQVTNMVWEKITPKDLFDVSPINIPTTEKSEIGNYTNPYTGEKTNNIRVAALRSDNGNFYRLTSFSLSAASPALQGKTAGTSKLGTTDNPLKSGTFYKIKVDKTGIFKITAQFLRDNGINPGSVNPKNFRIYGNGGMMLPEHNMDQRFAALQENAIQVVGEDDGSWNDQDFALFYAQGPNGFNVYRTQSSDNIKRIETRQDASSNFVNVYEDFAYYFINFDLGPGKRVLDADLAVTSDVITRYDEYQYINEEKFNLMKVGRMWTGDAFNDTKTVTFTTKSPIQPTDVIKYRSRVIGYQSSGNRIDISLNNVSPSQSAIPSDFAKEIYPINYPSQGHGSATNLQGTQLTFTYQPTTSGNPNGKFYFDYAEVQYKEDLKYIDTQFNFRSYSVTEKSGNTYTFRIDNAAAVEQVWQVSDITNASRKINKSGNSGQFTFAYAANNQNFGNEFIAFKNADAFAPSFVGKIENQDLSALQNISYLMITVPEMMSQAQRLAAFYQDKFNVAVVDVNKIYNEFSSGSKDITAIRDFTTRLNTTSGKLQYLFILGDTSYDFRGKNNPGSDIVPSYQSEESRDYELSFVTDDYYTMTKPQPVTSISVASTLPDFPVGRLPAANISEAKLLIDKTLAYNNALPGQPSPFGEWRMKLDFVVDDDYDGGTPFHDTMNSSLVNVFETGTERKEYNVRKLYLDAFQAQTSAGGQRYPQVNQAITNDMGNSLYLFYFGHGGINGWAQERVLSVEEIQNFNNYNNVYARFPLVSTITCEFTLWDEPSTFSAGEQVIKSKQGGASMMLTSSRAIGVTYGEQFTTILTRHLFEITNDDFVPVGEAFLQAKIEKGTHADHLKVNLLGDPATKLSRPKRQLIIDKVETPVEGQLRALDFVKVKGHITKADGTVDTGFNGRVAINIFDKRLNKKTLNNDNAADLNPVLSYTEENGPIVKSSGQAVNGVFMVEFYVPKDINYEVGNGRILAYADNKVFDVFNNQVQTVGGINPEGINDNQPPQVQLFMNNTNFADGGITDQNPMLLACVTDDKGINSTGSGIGHDITVILDGKIIDTAVLNDFYFSGDGNGCVSSSLADYQKGNVSYPFRNLAPGPHQLTFKVWDINNNSTTGTLNFVVKDEADQALVINKPLNWPNPFTNRTYVQFEHNCDDMLDVNVQIYTITGKLVKTISTTVTAEPFYQGYRTPRTAIEWDGNDDFGDAVGKGTYIFKIFARSQNQDKCKGSATAVEKMVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T6</accession>
    <name>C6X3T6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782221.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00619"/>
    <dbReference type="EnsemblBacteria" id="ACU07074">
        <property type="protein sequence ID" value="ACU07074"/>
        <property type="gene ID" value="FIC_00619"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00619"/>
    <dbReference type="eggNOG" id="ENOG5030W1Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233520_0_0_10"/>
    <dbReference type="OMA" id="RELTHIW"/>
    <dbReference type="OrthoDB" id="1682060at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="224" mass="26649" checksum="F92D72668E3E4A35" modified="2009-09-22" version="1">MQTRKHTAWKKNRKFGDVWGGRTFPKLADKIFNRQHNLSAPKNDETTPIYIIDNPSRDFYFPITVDEIKSTLEKLPKDHTDHLTHIWLQKIKKTDYVNGDTFQGSFICGSKVYLIVLHPFPTDNKMRLGKSKPLKKTLNYYKNYTTDLKEDKDSWYLQWTEELIKKYFLESLLLHEIGHSIDSFYKRYWSKAIKVKSENFADNYVAVWADKVRETYEPKEKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X8</accession>
    <name>C6X3X8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782262.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00661"/>
    <dbReference type="EnsemblBacteria" id="ACU07116">
        <property type="protein sequence ID" value="ACU07116"/>
        <property type="gene ID" value="FIC_00661"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00661"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092206_2_1_10"/>
    <dbReference type="OMA" id="ARNRYKW"/>
    <dbReference type="OrthoDB" id="2019103at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="135" mass="16035" checksum="210ABA82C26EA52C" modified="2009-09-22" version="1">MTDPTKYYLFYDGDCGFCNHWVQWILQNDSKQQFMFASLQSEFGQNFLDERNLDKNQFSTVYLWKPGSFYHTKSRAAFEIAKVLGGKFTLLSYLRVLPSSITDFFYEIVAKHRQKLATQKCFLPSPQERKRFIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z4</accession>
    <name>C6X3Z4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha amylase, catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782278.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00677"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07132">
        <property type="protein sequence ID" value="ACU07132"/>
        <property type="gene ID" value="FIC_00677"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00677"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005821_0_0_10"/>
    <dbReference type="OMA" id="TKGFTQN"/>
    <dbReference type="OrthoDB" id="227746at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973673" evidence="1">
        <location>
            <begin position="20"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="387"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="956" mass="105047" checksum="7131E3D391B6780F" modified="2009-09-22" version="1">MKYFYTLILAVLLPYFAVAQQVVSYTVNPASFDETDAITVTFTVNETAFGVASTHSLYLWAWSVDSNNASADAPTNGTWTASNAANKLTYVSSSGGTGTYTFTMNTVKSFYGNRPNPLAKIGFLVKTVNGSAQSQDIILNVGRFQFNLTNPLSGSTNVVSSGAVINITGTSSAAANYTVKANGSTVYTSASASTSLNYAYTVTQDASIEVIATNPVDGSSIAKSFTVSLALPVESAAIPAYMKQGINYDPGDPTKVGLAIYAPGKPYMHVIGSFNNWTVSGNYLMKRDTANPNLYWIEITGLTPQQVYTFQYRTADGVKVADPYSPLVLSPYDDPYINQNAVVYPNLPVYPAGQNFEVSVIQTGKTPYPWVVTNFAKPAKENLIVYELLVRDFTTEKTWQSLIDKIAYLKSLKINAVELMPVMEFEGNNSWGYNTSFHYALDKAYGTPEKFKEFIDLCHQNGIAVILDIALNHATGRSPLQRMWMTDPDGDGFGDTSADNPYFNQVPKHSYNVFNDFNHSKAETKYYTNRVIEHWIKEYKVDGFRWDLTKGFTQNCTAGDDACTNSYQQDRVNILRSYADNQWSHDPTSYIIFEHLGTDSEEAQWANYRIGEGKGIMMWDKQTNAYNQNTMGFSATSNFNRVDFEAHGFTDRRAVSYGESHDEERIMYKNITFGATSPEYSTRDLNNALQRQKAYGAVFLTVPGPKMIWQFAELGFDKSIYTCEDGVTVNTEGDALPGDCKLSPKPTAFGLGYDTDAARKSVYDTWAKILELRLSNDVFNTKTFTVESGNLMPRIFIWKDASASALKNVVILANFTLTPQNIVPNFPYTGNWVNLLDNTSVAVANATAPITIEPGGFRIFGNASGLATDEVGSGKNAVTLTLNQNPVSNGVANIRYSNAKNGSLAIYDLSGALVKTVKVSKDSGEEAISVAGLKTGMYLIQLKSDKGVAVTKMIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X412</accession>
    <name>C6X412_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable phosphoglycerol transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782296.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00695"/>
    <dbReference type="EnsemblBacteria" id="ACU07150">
        <property type="protein sequence ID" value="ACU07150"/>
        <property type="gene ID" value="FIC_00695"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00695"/>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014653_3_1_10"/>
    <dbReference type="OMA" id="QQIDIYP"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="8">
        <location>
            <begin position="270"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="640" mass="73847" checksum="8E110C364EE04414" modified="2009-09-22" version="1">MKEFRLQEIAVLFYRIFLAFVFYQIARFLFWMYNKDLIKIDSVSEYLGIAYHGTAFDTTAILYVNSLFILASLLPLLINTKRNYQKFLLWLYFVLNGIAYAMNFGDFVYYKFSQSRLTMAAMNVAQNEDNIGRIFLVSVAEHPFVIIWFAALMSLWVFLYKKVKISERKPRVKWIYFVSSVVTLCLVATLVVGGIRGDFRHSTRPINLVDANRHVKNPLQANVVLNSVFSFFRTLTTNNFKEVHFVDEQFINQHIQPYKIYVSKETDPKPNVVIFILESFSKEYSGAFNRDTNIKNFKSYTPFFDSLAQHSLIATNAYANGRQSIHGMSSILAGIPALKDAFTGSPYANQKIQSIVSVSNEMGYDTSFFHGAPNGSMGFLGFGNILGFKHYYGKTEYGDDADFDGMWGIWDEPFFQFFAQTLNTKKQPFMATMFSVSSHHPFKVPQKYEGKFPKGTVEIHAPIGYTDYSLRKFFETAKQMPWFQNTIFVMVADHTNQVAYPEYEKAMNRAAIPIMFYSANPKYNLRGEITEPTQQMDIYPTLADLMGYNRKIRSWGRSLVSEKKEDYLIVNSSGVEHFIIGNYIYLFDGQNVTGIYDKNDLGFEKNLIGTVNSPEIQLGKLKAKAWYQDYMDRVINRKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X446</accession>
    <name>C6X446_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782330.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00729"/>
    <dbReference type="EnsemblBacteria" id="ACU07184">
        <property type="protein sequence ID" value="ACU07184"/>
        <property type="gene ID" value="FIC_00729"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00729"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041533_0_0_10"/>
    <dbReference type="OMA" id="YFEIFYA"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="492" mass="56485" checksum="78D7C627F289A1FE" modified="2009-09-22" version="1">MSVVARQGFKYSLIGYFGFLLGTFSAIFVFPHDMEFYGKLRYVLPTAEMLLPIVVFGLSFSNVKFYTKTREDGKHQNFLSLSLLGIALNFTLFVVGYFAVNYLFPELQKTEMWQMKRLILPLILVLAFSAIFNKYLSNFKRIVIPNIFENLLPKIANLGAFCIFFFLGFPEKAAYIFFVAMFVVGLFGYIYYTNRLEKLKPDFSTEYIKKDNLWKDVLNYSFYGFLGNIGNFIAVRIDSVMIGEFLGFEPNGVYNTLYSIISLITVPAMGLYSISAPIINKHLAENNLEELDRLHKKSSLVLFFLGFVLLSCVLVGFPFLTDFIKNGELLRQSEPVIWVLGFAMLFDLATGFNGHIISLSKYYRFNIVVMLFLAVTTVSLNIYFLKNTELELFGVAIATAISLTLFNIAKIVFNYIKFGVFPLSIEMVYALIIGTLSITVVIILPQFERSIFNLFYKPGVVLLMFFVGNHFLKIFPLEEYINRDFLKSLFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>C6X470</accession>
    <name>C6X470_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="8">HTPA reductase</shortName>
            <ecNumber evidence="8">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapB</name>
        <name evidence="11" type="ordered locus">FIC_00753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782354.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00753"/>
    <dbReference type="EnsemblBacteria" id="ACU07208">
        <property type="protein sequence ID" value="ACU07208"/>
        <property type="gene ID" value="FIC_00753"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00753"/>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_1_0_10"/>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="10">
        <location>
            <begin position="102"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="8">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="238" mass="26346" checksum="25AA073BFFCE4F73" modified="2009-09-22" version="1">MKIALVGYGKMGRIIDGIATSRGHEIVARLNESPTPENLNNPDVVIEFSNPEVAFTNIKTCLENKIPVICGTTGWLGQKPEIERITAENSTAFLYGSNFSLGVNLFFELNEKLAALMQNLGEYNVQLEEIHHTHKKDAPSGTAISLAEGIINNTQKFDAWKLEETKGNQLGIFAVREDEVPGTHSVFYRSEVDEIEIKHTAFNRNGFALGAVVAAEWIFGKTGNFTMKDVLLDKMTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X487</accession>
    <name>C6X487_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00772"/>
    <dbReference type="EnsemblBacteria" id="ACU07225">
        <property type="protein sequence ID" value="ACU07225"/>
        <property type="gene ID" value="FIC_00772"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00772"/>
    <dbReference type="eggNOG" id="ENOG502Z9EE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319974_0_0_10"/>
    <dbReference type="OMA" id="FNINAVA"/>
    <dbReference type="OrthoDB" id="30482at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005340937" evidence="1">
        <location>
            <begin position="32"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="934" mass="104783" checksum="192374F8B96A2C6C" modified="2009-09-22" version="1">MRPLNEIPTSVLRTAAFFLAFVLLNFSFAFAQEKKVVEIHFENETVTVEKGSTFTNFLVIENNSSEEITIQNIIPQEKYPGLLLYPKIDFTLGAGQSKRLPVKLIANLEFMKLRSNEIRFNISYTASTYTQTESASFFVKKDENKNIAVYTASYENFINPAEPHSSIRLYVENQGYSKRTVKIDLQSIPDGLEMIPAQQTLSLEGLEKQMVEIKIVVRKQNTLFPEFNINAVATDLADNEIVGSNTVHLVILSNNRQIARGNETVSGSNFAEVGYNENSSGFNYLQLRGNTAFAVAPNMSARLNLGADYFLEEGRYNLYDTWLEVERKNTVLRVGNINGNDYDYAVYGRGGKVSTRLGTTGQVEILAVENNFNLYGNYFQQAEGSKMAGAKYSFGNGKTFNGKASYILDHDPRFGVDTQVANAVSSFLIKEKQTVRLEAGLSHEKGLTNKDENAGASMGFNYSGTLGKWDIQSDNSFATKSYAGLKRGSFFSNQRVGLRVTDSQRAFVQYQNSQVDPEFLSFQSAPVQAGNAENVRYYFNSTEALGTGYQVSLKDWNFLIAPKVERQKTANFYNSQELFSYRLETNIGTALGAHGLNLTAEYSYSKENENPDWFNSLKTTLSYRYKSFSLNGTAQWNATNVFDLNSFYDVDRNFANYNVYASCNFQMLGNDLIGSFSAGTSYSELYKNLNSNITGNLEYKISPSWSSTGYFNFSGYKSNAAFGSSGSYYQYRVGIKKYFASATAPGNHKVAFQLFEDKNYNGLLEAGEPVLAGEIVKLDSFVAMTDKNGKVVFQNVPQGTYTLKVNESAGARLMMDPVMMVSSNINRKVGLVKNIRLTGKLTEIRQAYDVLETDVTGIVVYAKSEDGTVHTSVVNQNNEFEFFLKHGKYEIYIENDKYSYTQPVQTVQVTKEGFTDTVLFEYKKKDTTIKVKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E6</accession>
    <name>C6X4E6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_00831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782430.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00831"/>
    <dbReference type="EnsemblBacteria" id="ACU07284">
        <property type="protein sequence ID" value="ACU07284"/>
        <property type="gene ID" value="FIC_00831"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00831"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_10"/>
    <dbReference type="OMA" id="YLTMEDV"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="223"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="291"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="452" mass="51709" checksum="772576C31D89FBB4" modified="2009-09-22" version="1">MDSDVVKLLLALFLVLLNGFFVAAEFSIVKVRYSQIQLKAAEGNAMAKQAEHIIKHLDEYLSATQLGITLASLGLGFVGESALHHIIENFFHYFSWDVPQTTVYTVSLVLSFLLITIMHIVFGELIPKSIAIRKAEPTTMAIAMPLRVFYVVFKPFIWSMNQMSNGVLRLMKIHPASEQEIHSTEELQLLVKQSADSGEIEEENYEIIKNAFDFTDHSAKQIMVPRQNIASIDIEDPIEEIIEKIMDSGYSRIPVYKGSIDNIIGIFYAKEIIREYIRRKTDITHESLNELMREAFFVVGSKKISDLLKVFQQKKQHLAVVIDEFGGTEGIITLEDILEELVGEIQDEEDDEDKIVERIGENVYWVQATQNLDEINEHLPKIFPLSEDGEYNTLAGYILHELEDIPEENQEFEMNDYHVKILKMQNKSVDLVELMYEEPSLLGDMADELTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F8</accession>
    <name>C6X4F8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="5" type="ordered locus">FIC_00843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782442.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00843"/>
    <dbReference type="EnsemblBacteria" id="ACU07296">
        <property type="protein sequence ID" value="ACU07296"/>
        <property type="gene ID" value="FIC_00843"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00843"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_10"/>
    <dbReference type="OMA" id="IWLNANE"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="42"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="340" mass="37895" checksum="129F55C1BE9B0271" modified="2009-09-22" version="1">MEFNLEKMLRPHLKSALVYTNTRPTESSDGLIYLDSNESPVGKYNRYPDGEQKALKGKLAAINGVSADRLFMGNGSDELIDLLMRIFCEPGSDTIMCLDPSFSMYEVYADFNNLKIEKLRLNGSFQLDKEVFDQCVSETSAKILFICSPNNPTGNSIEDLAYFISKFEGLVVIDEAYIEFSPNDSATKLLVQFPNLVVLKTLSKAHGMAGLRLGVGFASPEIARLITRLKPPYNISSESQRIAAEELDDGMKFNKNVGLILSEKAKLVDALEQIRAVKKVYASHANFLLVEFADADEVYRILIKNQILTSLRHPGIPNCIRITVGNPEENLKLISILTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4G6</accession>
    <name>C6X4G6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="6" type="ordered locus">FIC_00851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782450.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00851"/>
    <dbReference type="EnsemblBacteria" id="ACU07304">
        <property type="protein sequence ID" value="ACU07304"/>
        <property type="gene ID" value="FIC_00851"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00851"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_4_3_10"/>
    <dbReference type="OMA" id="PKIKTHR"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="65" mass="7429" checksum="DB36823C9A7743D5" modified="2009-09-22" version="1">MPKLKTKSGAKKRFKLTGTGKIKRKGAFKSHILTKKETKQKRNLTQTSYVAEVDKKSVLRQLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4J0</accession>
    <name>C6X4J0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782474.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00875"/>
    <dbReference type="EnsemblBacteria" id="ACU07328">
        <property type="protein sequence ID" value="ACU07328"/>
        <property type="gene ID" value="FIC_00875"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00875"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_10"/>
    <dbReference type="OMA" id="FVTQDTQ"/>
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    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="351"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="385"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="600" mass="67725" checksum="4A661D9B0306F45D" modified="2009-09-22" version="1">MKTLLRYLKPHKWLLILSLLLATVNQVFSLFGPAITGNILDMLVTHPNHFDKEKLLPRNLDQYLYGTDLYHGVFYFLGLLIGTAMVSRIAKAFQDYVVNVITQKFGAHIFTDGLQHSMALPYQEFEDQRSGETLSILTKVREDSVKFITNFINIFFGILVSIVFVSIYALQLHWSIMPVYVVGIFIISFITNLLSKRIKHIQKTIVAETNTLAGSTTESLRNIEIVKSLGLTRQEVKRLNSNTYKILGLELKKVKNIRSLSFIQGTMVNFLQQLITLTLLFLIFKNIVTPGQYLSLMFYGFFIFGPMQEIGNIIISYREAQASLHNFDTLMQKPPEEKPKTPKKIGGIEKLAFTNVSFQHRSASYKALNAISFEVKNGETIAFVGPSGSGKSTLVKLLVGLYRPNEGSIYYNNINGSEFDFDELRNQIGFVTQDTQLFAGSIKENLLFVNPEATDADLQMALKKSSATALIQRAEHGIDTVIGEGGFKLSGGEKQRIAIARALLRKPHLLIFDEATSALDSITEEEITSTIKDVSKDKEQITVLIAHRLSTIMHADRIYVLEKGNVIETGSHENLLQLKGLYYAMWRQQIGERKMVEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4J3</accession>
    <name>C6X4J3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782477.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00878"/>
    <dbReference type="EnsemblBacteria" id="ACU07331">
        <property type="protein sequence ID" value="ACU07331"/>
        <property type="gene ID" value="FIC_00878"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00878"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_0_0_10"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="396" mass="44180" checksum="4AA8050DB7A6BB00" modified="2009-09-22" version="1">MEKVVLAYSGGLDTSFCAVYLSKVKQLEVHAVMVNLGGFSEEEIKKTEERAYQLGVKSFHVIDDAQNYYDNCIKYLIFGNVLKNNTYPLSVSSERVFQATAIAHYAKEIGAKAIAHGSTGAGNDQVRFDSIFQILLPEGEIITPIRDLKLSRNEEIEFLKENGFEINFEKSQYSINKGLWGTSVGGKETLTSNLSLPETAYPTQISKTEPEEMTLTFEKGEITAVNGEKYLKPIQAIKKIQEIAQAFGIGRDTHVGDTIIGIKGRVSFEAAAPLIILKAHHLLEKHTLTKSQLLLKDQLSLTYGNYLHDGLVLDPVMKDIETLFENSQKTVNGTVKILLKLYHFNLIGVESPNDLMSSEFGTYGEMNKTWTESDVKGFSKIYSNALSIYHQVNNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4J6</accession>
    <name>C6X4J6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-succinylornithine carbamoyltransferase</fullName>
            <ecNumber evidence="2">2.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">N-succinyl-L-ornithine transcarbamylase</fullName>
            <shortName evidence="2">SOTCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argF'</name>
        <name evidence="6" type="ordered locus">FIC_00881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
            <dbReference type="ChEBI" id="CHEBI:58862"/>
            <dbReference type="EC" id="2.1.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.11" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782480.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00881"/>
    <dbReference type="EnsemblBacteria" id="ACU07334">
        <property type="protein sequence ID" value="ACU07334"/>
        <property type="gene ID" value="FIC_00881"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00881"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_3_10"/>
    <dbReference type="OMA" id="VYVKNWS"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02235">
        <property type="entry name" value="SOTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043696">
        <property type="entry name" value="ArgF'-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="4">
        <location>
            <begin position="183"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="2">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="2">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="317" mass="35893" checksum="41DACBEE63C7F6D8" modified="2009-09-22" version="1">MKNFTSVHDISNPEILVQEALELKKDLYGFDDLGKNKTLGLVFLNPSLRTRMSSQKAGMNLGMQVQVINAGQDAWNWEFAENAVMDGSTVEHIKDAAKVLSEYCAVIGLRCFPDLKDRDEDYSEFVLNYFIKYATVPVISLESATRHPLQSFADLITIRENWDKPHKPKVVLSWAPHIKALPQAVGNSFAEWMNAADVDFSIANPEGYDLSKDFTGDAKVYHNQQEALKDADFVYVKNWSSFDEYGAMPEVKGNWLLGEEFLKTNPETKFMHCLPVRRNLEMSDAVLDSANSLVYQQVNNRTLSAQLIIKKILENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U0</accession>
    <name>C6X4U0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782574.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00977"/>
    <dbReference type="EnsemblBacteria" id="ACU07428">
        <property type="protein sequence ID" value="ACU07428"/>
        <property type="gene ID" value="FIC_00977"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00977"/>
    <dbReference type="HOGENOM" id="CLU_147287_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="13847" checksum="850FA1C4E19D0097" modified="2009-09-22" version="1">MDNKQTVQQFLDNLFFDNEKAFEVVANDIRVNWPGFGMEDIVGRENLRNFFVESGPEKVLQQTIENLIEEGNTVIADGKIVTIHKGKQETSYFADVYKLNNGRITSLISYMVLDKSNPENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W9</accession>
    <name>C6X4W9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PrpE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782603.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01007"/>
    <dbReference type="EnsemblBacteria" id="ACU07457">
        <property type="protein sequence ID" value="ACU07457"/>
        <property type="gene ID" value="FIC_01007"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01007"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_5_10"/>
    <dbReference type="OMA" id="YVFVMGR"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="65"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="512"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="633" mass="70443" checksum="40D006FFC8236BC8" modified="2009-09-22" version="1">MKANKMFRDSVEDKERFWAEQAENIEWFKKPTKILTDDGNTYPTWFEDGELNTCYLALDKHINDGFGDQVAIIYDSPVTSRNLKYTYSEVLDQVSRLAGGIRDLGLKKGDTAIIYMPMIPQSLFAMLACARLGVTHSVVFGGFAPTELAIRIDDCNPKAIITASSGMEVSRRIPYLPFVREAISIANHKPKHIIAYDRKLLGNRLDFSEGSGLTDFDKLIENSEPAECVPLESTHPLYILYTSGTTGKPKGVVRDNGGHAVAMKFAIKNIYGANEGETFWAASDIGWAVGHSFSVYAPLINRNTTIIFEGKPIGTPDAGTFWRVIEEHKVSVMFTAPTAIRAIKKEDPDGELVKKYDLSSLRTQFLAGERCDVATLDWYEEFVGVPAIDHWWQTESGWPMLGLMPGVEDVKIKRAAAGKPIPGYDIKIFSEEGYELEAHHEGYLVIKLPLAPGAMTGIWGDPERFKFGYLSRFPGYYFSGDGAIKDEDGYVFVTGRVDDVINVAGHRLSTAEMEEVVAAHKDVAECCVVGIDDELKGQVPFAIAVLKSGSKADQEQLEKDIVALVREKIGAVACLKNAMVVTRLPKTRSGKILRKLIRTMLDGKEYQMPSTIDDESIVEELQQMMNVYKKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y0</accession>
    <name>C6X4Y0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">carB</name>
        <name evidence="17" type="ordered locus">FIC_01018</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782614.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01018"/>
    <dbReference type="EnsemblBacteria" id="ACU07468">
        <property type="protein sequence ID" value="ACU07468"/>
        <property type="gene ID" value="FIC_01018"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01018"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_0_10"/>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="132"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="672"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="931"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate synthetic domain" evidence="13">
        <location>
            <begin position="548"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="931"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="821"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="833"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="835"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU07468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118239" checksum="AD08A942B55AEA28" modified="2009-09-22" version="1">MKRTDIKTILVIGSGPIIIGQAAEFDYAGTQACLSLREEGYKVILINSNPATIMTDVEIADKVYIEPISLQFVSHIIRKERPDALLPTLGGQTGLNMAVELQNSGILDECKVEVLGTKLSAINQAEDRDLFRELMRELNEPVPDSDIVNTVQGALEFAERIGYPVIVRPAFTMGGTGGGIAHNDEELKEIASFGLKYSPVTQCLIEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPVGVHTGDSIVVAPSQTLSDREYQMLRNSSLKIIRALGIEGGCNVQLALDPHSFDYYIIEVNPRVSRSSALASKATGYPIAKIAAKIAVGLTLDEIMNPVTGKTYACFEPALDYVVTKFPRFPFDKFETADRRLSTQMKATGEVMAIGRNFEESLQKAIRSLETGLRHIGLKTKQAEALTDEEIERRIRVCDDERLFIIGDALRRGYDWEKIVEWSKIDKFFIWKIKKLIDFEKVITQNKFNTDILLKAKKLGFADLSIAHLWDSTQKEIFEFRRSNNLMPVYKMVDTCAAEFESETPYFYGTYEEENESIPSDREKIIVLGSGPIRIGQGVEFDYATVHSVWAIKELGYEAIIINNNPETVSTDFSISDKLYFEPLTEEDVMNIIELEKPKGVVVQFGGQTAINLADKLAAHGVQILGTSLEDLDRAENRNKFEAALQEMGIPQPLGKTCFTKEEALIIANEIGYPVLVRPSYVLGGRAMEIVYDDKDLSYYMTNAVKESSEHPILIDRYLTGREVEVDAISDGETVVIPGIMEHIERAGVHSGDSIAVYPPQNITPKQIETLVDYTERLAKGLNVIGLMNIQYVLSDGNVYVIEVNPRSSRTVPFLSKITEIPMANLATKAILGQKLKHLGYKNGLAPVKEGVYVKVPVFSFSKLTKVDISLGPEMKSTGEVMGKDTTLEKALYKGLIGSGRKMPLHGAILFTVADKDKEDACEVARRFQEIGFKIWATEGTANFFEERGVRTKIGYKIEENPEINLIDLIQTGKVQYIVNTMTKGKQSERDGFQIRRTSVENGVPCLTSMDTVEAILKVIESMSFKMEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y6</accession>
    <name>C6X4Y6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01024"/>
    <dbReference type="EnsemblBacteria" id="ACU07474">
        <property type="protein sequence ID" value="ACU07474"/>
        <property type="gene ID" value="FIC_01024"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01024"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_5_0_10"/>
    <dbReference type="OMA" id="WRKFACY"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="32494" checksum="187D51F6C42F00D7" modified="2009-09-22" version="1">MKDCPILTVFENTGIYSNPLARFLHENGWHYAEVSALEIKRSKGLSRGKSDRVNARQIALYGLRNRDKTVLSSGPETLHQQLKILNTEREKILSAINSFSRTSEAEDFLRREVYRVVKAIIRQTMSALKKQLAALDEKIGQLIRSDEDLKHKQELLKSIPGIGEIGSIYFLLVTKGFTRFKNWRKFACYCGIAPFEYSSGTSIRGRNRVNPLADKKMKSLLHLLSLTSIRHDEELKLYYNRKKEEGKHSLLALNNVKCKLVSRIFAVIKRDTPYVKTHQYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X507</accession>
    <name>C6X507_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805780.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01045"/>
    <dbReference type="EnsemblBacteria" id="ACU07495">
        <property type="protein sequence ID" value="ACU07495"/>
        <property type="gene ID" value="FIC_01045"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01045"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030864_0_0_10"/>
    <dbReference type="OMA" id="NEAMENF"/>
    <dbReference type="OrthoDB" id="909263at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970682" evidence="2">
        <location>
            <begin position="24"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="462"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="575" mass="67789" checksum="4C587A78593B9CA5" modified="2009-09-22" version="1">MLLKNIYALLVLLCLSFFSHIHAQSDSYSTLTNEEIEKKIDSYNNDPDKMWELIKFYVKKSKKEKNNEALFYAYRYASINSIYPINLKYADSALATAKKSGISKIQLDAYLNRGIIQMSEESYQKALNDILIANILSQSSGNDYIYNKTIYFIGQNKIYLGHYEDAKKELEICLDFFKNNLESKTSLGRNYEMYYLYSLLSLIDSNTRLGEFKENKVLLTEAFTYLRTNNLKIYLPYFISSEGTDAYYAKDYDKAISKLSQAIRLYNDQWPHNTEVFYLGLSYWHTGKQKLAVKYLEEIDKHYTKTKKLDPQFRSAYEILIKYYNSTGNTEKQLEYINKLMFLDRSYEKNYKYLYQRIVKEYDTKKLVAEKNRIEHTLQNQRIIFVGLLVALVIGFLIFGYRISKEKQNYKKRFEEIFAQQNVEVVAQPENSALGVTDYDGQQRFDYDFYNKIPGLNPIFVENILKQLETFESEHKFLDPQVSQKSLSEELGTNSTYFSKIINTYKGKNFTLYINDLRLEYIIEHLKTDVKYINMDVKELASIAGFSSAENFSDNFRRKFDLKPSVFIKMMKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X553</accession>
    <name>C6X553_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805826.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01091"/>
    <dbReference type="EnsemblBacteria" id="ACU07541">
        <property type="protein sequence ID" value="ACU07541"/>
        <property type="gene ID" value="FIC_01091"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01091"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103745_0_0_10"/>
    <dbReference type="OMA" id="NQRFLIH"/>
    <dbReference type="OrthoDB" id="1812959at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="26012" checksum="4B951543CF771568" modified="2009-09-22" version="1">MASKKNDIFWISYADLLSSLFFIILVLFAITFFKYNQKVENLKKKLEVFRLVEESLGPLKKKKDIFKYESDYKRFVLAEEVSFNISKTDITPTDVKDFPAKSAYLLKVGKGLKNTLDTIAYHRTKKEGLKDVSYLLVISGYASKLSVANEAEDYNLSYDRAYNLWKFWKRNGIDFEDLKYKGFVDLQIAGNGWGGMGRISSKNNSEEEGNQRFIIQIIPKTKNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X565</accession>
    <name>C6X565_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07553">
        <property type="protein sequence ID" value="ACU07553"/>
        <property type="gene ID" value="FIC_01103"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01103"/>
    <dbReference type="HOGENOM" id="CLU_3365103_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="3759" checksum="F24399FDE2C3BF5F" modified="2009-09-22" version="1">MVAPTVNIIVYSIAVVPDKTDVIPSLRGTSFAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>C6X591</accession>
    <name>C6X591_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01129"/>
    <dbReference type="EnsemblBacteria" id="ACU07579">
        <property type="protein sequence ID" value="ACU07579"/>
        <property type="gene ID" value="FIC_01129"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01129"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_10"/>
    <dbReference type="OMA" id="IVELTHH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="61"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="200"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="507" mass="56580" checksum="CB563E1AA9210B9B" modified="2009-09-22" version="1">MNCLNTQYLVSFSNFNRNMDGMGTYPVVVLRRDVNRGNSYGANHPILFLDLRNQYVSALKKILIIDDEEKLRSLLTRIIALEGFEVIQASDCQSGLKKLSQSDIDVVLCDVKLPDGSGVELAKAIKEKYPSTEIILLTAYGNIPDGVQAIKNGAFDYITKGDDNSRIIPLLYKACEKAALARRVQHLERQLEKKHSLTNIIGKSRTIRQAVELAKKVAGTDTTILLTGETGTGKEVFAQAIHQESTRRTEHFVAINCSAFSRDLLESEMFGHKAGAFTGAAKDRKGLFEEAHNGTIFLDELGEMALDLQAKLLRVIESGEFIKVGETKPTKVNVRIIAATNRDLAHQIALGHFREDLFYRISVFQIPLPALRDRTEDIAVLAQHFVDFFGHKMNKKILSVDPGFITALQHHAWKGNIRELKNVIERAVILSSGTELAPDDLPIDIQFHPSVKSGKQLSAFSLQSVEKLHIQKVLNHTQGNKAEAARLLEIGIATLYRKIEEYRLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5A9</accession>
    <name>C6X5A9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805882.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01147"/>
    <dbReference type="EnsemblBacteria" id="ACU07597">
        <property type="protein sequence ID" value="ACU07597"/>
        <property type="gene ID" value="FIC_01147"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01147"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_15_1_10"/>
    <dbReference type="OMA" id="EVEPTFN"/>
    <dbReference type="OrthoDB" id="1680841at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="4">
        <location>
            <begin position="59"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="84"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="384" mass="42609" checksum="B912C8AEB5536DA3" modified="2009-09-22" version="1">MSEQTPENENIIQPESEVKVSHKKHDQKPQPPTKKPNKKSNKVKTTVINLLVFAIAAGGFYWLVKHYFHLNDDNFTNSAQVEEFINPVNTRVAGYIKEIKYSEHEAVKKGDTLVILDDRELRTQLAQAEAAWQNALASREVTSSSVNTVSNNVNVANANIAGAKARLWNAEQNMNRYKNLLASEAVTRQQYDQVKTEYDATRAAYETLLSQKNSANLATGETRSRLGVNDAEIKRTSAMLDMARINLSYAVITAPYDGVMGRRLINEGQLVQPGQQLGTIVLNGQKWITANFLESQMPRVKIGEKMNITVDALDGKKFIGTVAAISAATGSKYSNVPVDNSTGNFVKVQQRIPVRIEFTADNKKEDLAQLRAGMNVSVTLNKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D8</accession>
    <name>C6X5D8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G:T/U mismatch-specific uracil/thymine DNA-glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805911.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01176"/>
    <dbReference type="EnsemblBacteria" id="ACU07626">
        <property type="protein sequence ID" value="ACU07626"/>
        <property type="gene ID" value="FIC_01176"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01176"/>
    <dbReference type="eggNOG" id="COG3663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094865_1_0_10"/>
    <dbReference type="OMA" id="QQYYAHP"/>
    <dbReference type="OrthoDB" id="2034230at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026353">
        <property type="entry name" value="Hypoxan-DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04274">
        <property type="entry name" value="hypoxanDNAglyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="162" mass="18683" checksum="2851E644E6FB3A0C" modified="2009-09-22" version="1">MAERITSFPPIISDTSRILILGSAPGIKSLQMQQYYAHPQNQFWKILFHLFDEEYAVDYDIRKALLFKNHIALWDVIDSCEREGSSDAKIRNEEHNDVLQLVTDFPNITAIFSNGQKSSKEARKMLGAESQIPFHVLPSTSPLHTIPFNKKLEAWKILKHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E1</accession>
    <name>C6X5E1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rlmN</name>
        <name evidence="14" type="ordered locus">FIC_01179</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01179"/>
    <dbReference type="EnsemblBacteria" id="ACU07629">
        <property type="protein sequence ID" value="ACU07629"/>
        <property type="gene ID" value="FIC_01179"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01179"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_2_0_10"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="110"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU07629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="358" mass="40669" checksum="25451616E6C53ED4" modified="2009-09-22" version="1">MALLTFYLALDINTMKDIRTLSLEELQNYFVTLGEKPFRAKQVYEWLWSKNLHSIDEMTNLSKDLREKIAQEYTINPISVDQLQKSSDGTIKNGVKLHDGLLVESVLIPTETRTTACVSSQVGCSLNCEFCATARLKRMRNLEVAEIVDQVALIDRQSKMYFDRPLSNIVFMGMGEPMMNYKNVVEAIRKITAPDGLGMAPRRITVSTSGIPKMIKMLADENLRVNLALSLHSAIEKTRNEIMPFSDRFPLTDIMDSLKHWYEKTGNIVTFEYCVWKGINDEDEDIKALIRYCKQIPCKVNLIQYNPIGDGKYDRCNKAAEENYVRQLENAGITVLIRRSRGGDIDAACGQLANKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E7</accession>
    <name>C6X5E7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805920.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01185"/>
    <dbReference type="MEROPS" id="C56.001"/>
    <dbReference type="EnsemblBacteria" id="ACU07635">
        <property type="protein sequence ID" value="ACU07635"/>
        <property type="gene ID" value="FIC_01185"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01185"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_10"/>
    <dbReference type="OMA" id="YAWMREF"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="179" mass="19333" checksum="81566A94EC1E8CCF" modified="2009-09-22" version="1">MSDLKNKKIAVLAADGYEQSELESPVEALNEAGATVEIVSLKAGKIKAMKDHEWSNSVPVDKTVSEVSVSDYDALLLPGGVINPDTVRGDEDAVKFVKDFFTANKPVAAICHGPQTLINAEAVQGRKMTSYQAISKDLINAGANWVDEEVVTDGNLTTSRKPDDLPAFNKRIVEEFGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F0</accession>
    <name>C6X5F0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytosolic long-chain acyl-CoA thioester hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805923.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01188"/>
    <dbReference type="EnsemblBacteria" id="ACU07638">
        <property type="protein sequence ID" value="ACU07638"/>
        <property type="gene ID" value="FIC_01188"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01188"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_1_0_10"/>
    <dbReference type="OMA" id="RFHTRKW"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="131" mass="14970" checksum="C588789AFFDEF43F" modified="2009-09-22" version="1">MNYHTRKWIKPEDLNPNHTLFGGRLLQWIDEEAALYAIVQLETPRCVTKYISEINFVSSARQGDIIEIGIEATEFGNTSITLTCVVRNMMTQQSIITIDKIIFVGIDEEGKPTKHGKTRIEYVADRLKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K1</accession>
    <name>C6X5K1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01241"/>
    <dbReference type="EnsemblBacteria" id="ACU07689">
        <property type="protein sequence ID" value="ACU07689"/>
        <property type="gene ID" value="FIC_01241"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01241"/>
    <dbReference type="eggNOG" id="ENOG5032S5N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124842_2_0_10"/>
    <dbReference type="OMA" id="HAYLDYP"/>
    <dbReference type="OrthoDB" id="1941441at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="13423" checksum="F3E48BF6E49A2D47" modified="2009-09-22" version="1">MISSKFHAVLDYTVGMLLIAAPWLLGFADDTAATIIPVALGVLTLVYSLITDYEYSVARLIPYRIHLTIDFIAGLLLLTSPWLFGFSDRVYLPHVILGAFEIVAVMLSRKATETVQRAEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M1</accession>
    <name>C6X5M1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01261"/>
    <dbReference type="EnsemblBacteria" id="ACU07709">
        <property type="protein sequence ID" value="ACU07709"/>
        <property type="gene ID" value="FIC_01261"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01261"/>
    <dbReference type="HOGENOM" id="CLU_1822488_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="141" mass="16033" checksum="DB2DDBE5BEC0D999" modified="2009-09-22" version="1">MFFLPNIVLRPCFLLKYHKRAIVDFILFRLFCFFGVNLTITGTNGVVETFNMYAPLSYTLPKGVQDFKMDEKTYFYISGSGEEGLVGEYLYEGKGEHKVVLSADGTGSFQRHMKPAEDLEWWGVETNYKGEIQKVTGDTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5N4</accession>
    <name>C6X5N4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806007.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01274"/>
    <dbReference type="EnsemblBacteria" id="ACU07722">
        <property type="protein sequence ID" value="ACU07722"/>
        <property type="gene ID" value="FIC_01274"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01274"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_0_0_10"/>
    <dbReference type="OMA" id="CFWVVQP"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="354" mass="40157" checksum="ADC647F55D015E67" modified="2009-09-22" version="1">MQKLFDQISVQKALIFTALFLVALILFELNYFMSGVLGAVTLYVLTRNFYLRLTEEKKWNSNLVITLIIFLVIITFAVPLWIILEILIPKINEIVSDREAIVEKYNAVRVFLENNQYTKRFDLQLSNERIMQAVNKVISYIPSTLNWVGQMLGNIFVALFILYFMLKQSRIMEQKFKELLPVSRESKKYFIQHNAALIRSNAYGIPILGLSQGIIAIIGYYIFGVENAIFWGLLTGAASIVPVVGTMIVYLPICIYQVATGDVNNGLFLAGFCLLFVGGIDNVLRLTLLKKMADIHPLVTVFGVLLGLQMFGVMGLVFGPVLLSMPGILYRIFEMERSFKVQHEHEEAQAETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S1</accession>
    <name>C6X5S1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Curli production assembly/transport component CsgG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806044.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01311"/>
    <dbReference type="EnsemblBacteria" id="ACU07759">
        <property type="protein sequence ID" value="ACU07759"/>
        <property type="gene ID" value="FIC_01311"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01311"/>
    <dbReference type="eggNOG" id="COG1462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575867_0_0_10"/>
    <dbReference type="OMA" id="VYVSKTI"/>
    <dbReference type="OrthoDB" id="628511at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005534">
        <property type="entry name" value="Curli_assmbl/transp-comp_CsgG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03783">
        <property type="entry name" value="CsgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973629" evidence="1">
        <location>
            <begin position="26"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="456" mass="50673" checksum="B81839F7BA8390D6" modified="2009-09-22" version="1">MKTNKLTKIALLTPLIFLSSCTLFNLPTNSEKSTLGEVTPYTPEIKNLPAPKEKIVVGVYKFRDQTGQYKAAENGASWSTAIPQGTTTILLKALEDSRWFTPIERENIGNLLNERQIIRSTRKEYAGNDANEAALLPPLLFAGIILEGGVISYDTNVMTGGIGARYFGLGAGAQYRQDRITVYLRAVSTSSGEILKTVYTSKTILSTSINGNFFRFIDTERLLESDIGITQNEPVHLAVTEAIEKAVLSLIVEGVRDNLWTNKQKTPNDFDKIIEGYTSEVKVNDARIVGNKFPQNDRGKFSAFLNAETFKLKGDYVDSKMNIGAKVGLKYFLSDHINAELNVATHTLENTDILDETTVMTELNLEYLMLPKFKLSPFVYAGAGTIILPTRTRYKAQVGGGLEYLFNKNMALRLSSQYDFGFTDDWDGFVNGKQKDQGVRIGLGVNYYFGSKKSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W6</accession>
    <name>C6X5W6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806089.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01356"/>
    <dbReference type="EnsemblBacteria" id="ACU07804">
        <property type="protein sequence ID" value="ACU07804"/>
        <property type="gene ID" value="FIC_01356"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01356"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_10"/>
    <dbReference type="OMA" id="FGWPAIH"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="358" mass="40259" checksum="8A8DAF1217D84FF5" modified="2009-09-22" version="1">MANPNKSLKFLEEYLNTASPTGYEHRGQKVWMNYITPFVDKVEYDHYGTCYGIINPEADFRVVIEAHADEISWYVNYITDEGLIYVIRNGGSDQMIAPSKVVHIHGEKGIVKGVFGWPAIHTRGISSDEPVPKLENIFIDCGAINKEEVENMGIFVGCMITYPDEFFELNDRYYVCRALDNRIGGYMIAEVARLLKENKKKLPFGLYITNSVQEEVGLYGADMIADTIKPNIAIVTDVTHDTTTPMIEKKKEGDQKCGKGPVVFFAPSVHHTIRELIVDTAKKKEIPFQRAAASRATGTDTDAFAHSNGGVPSALISLPLRYMHTTVEMVAKEDVENVIRLIYETLLQIKPSMNLKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y3</accession>
    <name>C6X5Y3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806106.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01373"/>
    <dbReference type="EnsemblBacteria" id="ACU07821">
        <property type="protein sequence ID" value="ACU07821"/>
        <property type="gene ID" value="FIC_01373"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01373"/>
    <dbReference type="HOGENOM" id="CLU_1076669_0_0_10"/>
    <dbReference type="OrthoDB" id="2114378at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="258" mass="29134" checksum="918059ADF65AD4EB" modified="2009-09-22" version="1">MKTFYFVWILILLNSCGPGESPHTETAQDVPAAQDSAMMPTPGAEESPDAKETEPANATLGFSYYPVIPQNETRDLRVFVKIDGKPGDVTKTIREIEKEDLEFTKINDSSVVCIIKNIQAYKKLSIKPIYDFEDFRITKISDSEPLANADPNEQELDFVNGNYWHWKVKAIAKTAHLGNITLLIKAETPAGQKLKLAERQINIKIDINEPEQTFADRAYTFADAHFKEILSLIVIPLVIFLFNVIRKRVIARKNNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X607</accession>
    <name>C6X607_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806130.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01397"/>
    <dbReference type="EnsemblBacteria" id="ACU07845">
        <property type="protein sequence ID" value="ACU07845"/>
        <property type="gene ID" value="FIC_01397"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01397"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_859832_0_0_10"/>
    <dbReference type="OMA" id="HATFFIN"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="78"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="323" mass="38107" checksum="0A9D2880B1B7A9F1" modified="2009-09-22" version="1">MKTQFLHITNSFSKSLSQDTLIKLTGKKVILPFYHTVSSDPAPHFSELSYFRTEKQFIEDLNYFCQYFETVQAGIFDVSKKQFHLSFDDGMSEMYDVVFPILKERNIHATFFINTDFVDNKKMFISHKKSLIKSEIKNFVQNQNLLSEYLNIDSSRLHDEISKVSSDEKVDEIARKIGIDFSAYLSDNKPYLTTKQIIELKNAGFTIGNHGRSHRNFNTLTFEEQKTEIEQVNHFLTEIGVEKLFFAFPYGDHQIKNKLFDWMYSEGIIHHSFGVSGLKIDGYPQHHHRILMEQSRFSAEEIVKAEYFYYIWKSFVFRNKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X611</accession>
    <name>C6X611_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806134.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01401"/>
    <dbReference type="EnsemblBacteria" id="ACU07849">
        <property type="protein sequence ID" value="ACU07849"/>
        <property type="gene ID" value="FIC_01401"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01401"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_10"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="561" mass="59488" checksum="30205CD9AE8983ED" modified="2009-09-22" version="1">MAEVIAMPRLSDTMTDGKVAKWHKKVGDAVKEGDILAEIETDKAVQDFESEVNGTLLYIGTEEGGSAPVDTVLAIIGEQDEDISALKGGASSQQAGGTSEKEGAGIPEENKTEQNVTDVETTKPVEKEQEGSTQSTDIPKGVEVITMPRLSDTMTEGKVAKWHKKVGDTVKEGDILAEIETDKAVQDFEAEVNGTLLYIGTEEGGANPVDTVLAIIGPEGTDVSSIISGGGKKAQKAPESSNSTTSDSKEVSENKPAVAASSGDERIAISPLARKMAEDKGIDVHALKGSGENGRIVKKDVEGFNAEAQPQKSASSSENAASAQPKAAPSPAFIQGEDSETPNSQVRNIIAKRLSESKFTAPHYYLIIEVDMDKSIQARKEINSLPDTKISFNDMVIKATAMALRKHPQVNSTWHADKIVHHGNINVGVAVAIPDGLVVPVLKNTDQMNYNQISAAVKDMAGRAKSKGLKANEMEGSTFSVSNLGMFGIETFTSIINQPNSAILSVGAIVEKPVVKNGQIVVGNTMKLSLACDHRVVDGATGAQFLQTLKTYLEQPLTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X628</accession>
    <name>C6X628_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ferric aerobactin receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01418"/>
    <dbReference type="EnsemblBacteria" id="ACU07866">
        <property type="protein sequence ID" value="ACU07866"/>
        <property type="gene ID" value="FIC_01418"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01418"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016599_1_2_10"/>
    <dbReference type="OMA" id="IWNIANS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="802" mass="90030" checksum="40F3F1F15B09722B" modified="2009-09-22" version="1">MPKFFTEMNFKFSFLFLFAALFVTAQVGSLNINVYDEFSKKPLSAEARIVGANGSTYSGTGNISVAEIASGTYTLEISSAGYNPSFLNDINVVPNQNLTFTVGLTRAAAEIQEVTITRKTYKTTVESPLSLRNITSEEVQKNAGSNRDVSKAILSFPGVGSTATFRNDLFIRGGSSAENKFYIDGIEVPVINHFQTQGASGGPRGIITVDFIKDVDFYSGAFPAKRNGALSSLFEFNLKQARKDKLGYKAVIGLDDMQLMVDGPLSKDQSWSGLFSVRKSNLQLLFKAIDLPFLPSYYDATFKVSKKFGNGDELYFLGMGAKDSFKFNEDAEPTLNNLTLIDRIPSSPQWNYTVGTGYRHLAENGTWLFTWSRNMLDNQSLKYYRNIETPENLLFDYKSQESENKIRIDRDFSWADYQFSAGTNINFANYYNDSVLKNVTQNSVNFDRIESDLNLLQYGFYLQTAKKFFDNRLQLSAGIRLDASDYSDETTNPLEQFSPRFSLSYKLTDEFAVNFNSGIYYQLPAYTALGYAESGNLINKNTLRYIRNAHLVGGVEYNGKNNLRLTVEGYYKKYSNYPFSLRNQISLANIGGDFGVVGSEPLDSRGFGETYGIEFLAQKRTVNDFYGIMAYTFGYSQFSNAAGVLLPSSWDSRHILSVTAGKYFNRNWNVGARFRMQSGLPETPYDLQRSALVNIWNIANSPVQNYSLLNSARGNLSHQLDLRGEKKWIFKKWQLTAYVDLVNAYGSKSPSALPVVNLQRDGQNNGIIANPQAPQNEQVYLLETGEQDSSTPLPYFGLIFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X676</accession>
    <name>C6X676_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoaspartyl aminopeptidase / Asp-X dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01466"/>
    <dbReference type="EnsemblBacteria" id="ACU07914">
        <property type="protein sequence ID" value="ACU07914"/>
        <property type="gene ID" value="FIC_01466"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01466"/>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_10"/>
    <dbReference type="OMA" id="YSRMRWK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972369" evidence="4">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="234"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="337" mass="35951" checksum="7C0762B22A3D6824" modified="2009-09-22" version="1">MAKFKPMKKSALALLLFASALCFAQKKYVMVIHGGAGTITRAAMTPEKEAAYRQKLAEALRTGYGEIQSGKSSVEAVAAAITLLEDSPLFNAGKGSVFTSDGQNEMDAAIMFGKNKSAGAVAGVQTIKNPIKAAIAVMEESEHVMLSGRGAEKFAQEKGLDIVLPSYFWTKDRWDGLQKAKQNENSKKTSKIYPKNSFDIDQKFGTVGAVALDKDGNLAAGTSTGGMTNKKWNRIGDAPIIGAGTYANGQVGISATGWGEFFIRATAARTLAAKMEYHNKNIETAAEEVIHEIEEMGGDGGLIALDKDGNVAMPFNTAGMYRGTVTNKGEIEVLIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B6</accession>
    <name>C6X6B6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806239.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01507"/>
    <dbReference type="EnsemblBacteria" id="ACU07954">
        <property type="protein sequence ID" value="ACU07954"/>
        <property type="gene ID" value="FIC_01507"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01507"/>
    <dbReference type="eggNOG" id="ENOG5030WNT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129833_0_0_10"/>
    <dbReference type="OrthoDB" id="1975897at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="153" mass="17768" checksum="3020B1F8818C9E63" modified="2009-09-22" version="1">MMKKMYIMLFLGLALMTYAQNMLSYRALMNKGVESETATKTLVANSQKAFEDTKKPIYQAFYAMGNLLLAKHTGNPVRQFSYFRKGKTSLDNAAKADPKNIEIRFLRYLTQLNAPSFLGYNKDLKADKTFILNEYKKSDDEDLVRRIRQHFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C7</accession>
    <name>C6X6C7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="11" type="ordered locus">FIC_01518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806250.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01518"/>
    <dbReference type="EnsemblBacteria" id="ACU07965">
        <property type="protein sequence ID" value="ACU07965"/>
        <property type="gene ID" value="FIC_01518"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01518"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_4_1_10"/>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="10">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="173" mass="18702" checksum="89260C77BC40AF87" modified="2009-09-22" version="1">MDIILKKDVENLGLEFDTVSVKPGYARNFLLPQGLALLATPKNRANLEATLEARKEEEAKLIADANAIVEQLKKTNITIATKVGAGDRLFGSINNANLSEELAKAGVNVDKKYIKIPGNTIKRTGKVEANIRLHRNVEHAFEFEIVSDAPPAPAAPKAAPAPKKVEETPAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E5</accession>
    <name>C6X6E5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806268.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01536"/>
    <dbReference type="EnsemblBacteria" id="ACU07983">
        <property type="protein sequence ID" value="ACU07983"/>
        <property type="gene ID" value="FIC_01536"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01536"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039822_0_0_10"/>
    <dbReference type="OMA" id="AHQIGTP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="386" mass="44393" checksum="1ED17D2CF2DE3BAC" modified="2009-09-22" version="1">MKRRSFLSKINNWVIYFFLTLAVTSVVVASVILIDYLRKEEIKRIELFATAIKYQQEEIIEDPMTLDLLLQISKTNNTIPVIVTDKNKQPLGIQKNIPEHIESDPQKMLSLLKKMENSYQPIELQMPDGNNQYVFYMNSTLLNNLRYSPYILGLLVLAYISFSFWFLRTIKKTDEGYVWAGLAKETAHQIGTPLSSMIGWIEILRMENENSEGVKEIENDINRLKTISERFSKIGSVPELNDLNINETLQQNYNYLKSRISTKVRFMLILPPHEVLIPHNRILLSWVIENIVKNAVDSMKGEGKLEIELYEKNRSTVIDFKDSGSGMTGYQANNAFKAGYSTKKRGWGLGLSLAKRVIKEFHRGDIKIAQTEVGKGTTFRITIRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F8</accession>
    <name>C6X6F8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted peptidase, family M16</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806281.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01549"/>
    <dbReference type="EnsemblBacteria" id="ACU07996">
        <property type="protein sequence ID" value="ACU07996"/>
        <property type="gene ID" value="FIC_01549"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01549"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_10"/>
    <dbReference type="OMA" id="FVDMPNA"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973752" evidence="1">
        <location>
            <begin position="23"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="81"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="199"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="681" mass="74758" checksum="15E3A09266663F1F" modified="2009-09-22" version="1">MKYRLKYIAAAFLIAGTLSAQKINRDEMPKPGPTPVINISKPKTFTLKNGLTVMVVENNKLPRVNMTLTIDRPPVFEGNIAGVNQVMADQLGSGTTTLSKDQFNKKIDFLGANLNFSSSGANANTLSKYFPEVLGLMADAIVNPKFSETEVESSKDRMIEGLKADEKNASSIATRVSNALTYGKNTSRGEFETETTLKNIKLADVQDAYKKYYAPDNAYLVVVGDVKFNDAKKMIEKSFAGWKKSGTQFPAMEPVANVGKTEINVVDVPNAVQSVVSVGNVHNLRMNDPQYFASMIANYILGGGGESRLFMNLREKNGFTYGAYSNLTASKYTPGFTSNASVRNEVTDKAIKEFMNELKDISTIKPDELANAKAKLKGDFIRSLERPETIARFAVNEKVQQLPADFYTNYLKSIDRVTAAEVSEAVRKNILHNQSRIFVAGKAADIYQDVEKLGYPVSYYDREANPAGKPSAKKMDPGITIQTVSDKYINAIGGLAAVQKVNSITTDAAAKVQGMDIDMNMIQARGGKMKMEIKMMGNTLQKIMFDGKEGSMEAQGQKTALPEDMKKELMASPELFPELLFAKSADYQLSGIENINGEDAYAVKKGSNTYYYSVKSGLKVGEIKTQKTPMGEMAVPTNFSDYKTVSGVLMPYKISQTIGGMPVDFIVSSYQINQAKDADFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI3</accession>
    <name>C6WZI3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00040"/>
    <dbReference type="EnsemblBacteria" id="ACU06518">
        <property type="protein sequence ID" value="ACU06518"/>
        <property type="gene ID" value="FIC_00040"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00040"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_3_4_10"/>
    <dbReference type="OMA" id="LNDIMFF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="12823" checksum="37E75A3BE1996C07" modified="2009-09-22" version="1">MASMTDIIFLLLIFFMITSSAISQSAIDVKLPQADAANPSAQDPSTVTIKEDGKYFVNDTEIAKEQLETVLVEALKNEASPTFTIRADENSKHKDVVFVMGIAETHKFNLAIATTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI8</accession>
    <name>C6WZI8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00047"/>
    <dbReference type="EnsemblBacteria" id="ACU06523">
        <property type="protein sequence ID" value="ACU06523"/>
        <property type="gene ID" value="FIC_00047"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00047"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_2_10"/>
    <dbReference type="OMA" id="RTEEHCA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973265" description="Peptide-methionine (R)-S-oxide reductase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="MsrB" evidence="5">
        <location>
            <begin position="56"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="181" mass="20622" checksum="793B5A680B4E7073" modified="2009-09-22" version="1">MSFSFMKILLSILALISMQMCSQVKQPQIKPIMENSTLKDNPYYSRTDRTKLTVSNSEWKQILSPDLYAIAREADTERPFTGKYNEFDELGDYYCAVCGNHLFRSDSKFSSTCGWPSFFEADKEGTAYNRDSSHGMERIEVVCKRCDSHLGHVFNDGPPPTGTRYCMNSVSLEFVGDSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK3</accession>
    <name>C6WZK3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fumC</name>
        <name evidence="5" type="ordered locus">FIC_00062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781685.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00062"/>
    <dbReference type="EnsemblBacteria" id="ACU06538">
        <property type="protein sequence ID" value="ACU06538"/>
        <property type="gene ID" value="FIC_00062"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00062"/>
    <dbReference type="eggNOG" id="COG0114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_10"/>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="11"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="408"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="463" mass="50363" checksum="7F5DDE399D4BEA92" modified="2009-09-22" version="1">MNYRTEHDTMGDVQVPADKLWGAQTERSRNNFKIGPEGSMPQEIIEAFAYLKKAAAYTNAELGVLSEEKRDMIAAVCDEILEGKLEGEFPLVIWQTGSGTQSNMNVNEVVSNKAQVNNGGVLGEKSVIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEHTLPSVEILRNTLHEKAEEFKNIVKIGRTHLMDATPLTLGQEFSGYVAQLDYAMKAITNTLDHLQEIALGGTAVGTGLNTPKGYDELVAKYISDFTGLPFITAPNKFEALAAHDAIVESHGALKQLAVALYKIANDIRMLASGPRSSIGEILIPENEPGSSIMPGKVNPTQNEAMTMVCAQVLGNDTTISFAGTQGHYELNVFKPVMAYNFLQSAQLLGDACISFNDHCAVGIEPNLPRIKELVDKSLMLVTALNTHIGYENAAKIAKTAHKNGTTLKEESINLGLLTAEQFDEWVKPEDMVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT5</accession>
    <name>C6WZT5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781767.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00145"/>
    <dbReference type="EnsemblBacteria" id="ACU06620">
        <property type="protein sequence ID" value="ACU06620"/>
        <property type="gene ID" value="FIC_00145"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00145"/>
    <dbReference type="eggNOG" id="COG4736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200390_3_0_10"/>
    <dbReference type="OMA" id="YFKESFS"/>
    <dbReference type="OrthoDB" id="2034717at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008621">
        <property type="entry name" value="Cbb3-typ_cyt_oxidase_comp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05545">
        <property type="entry name" value="FixQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="63" mass="7185" checksum="91BC3DB190FD6234" modified="2009-09-22" version="1">MIPQNVKDILSNSGNTSLFQTLALLLFLALFLGIVYYVFSRPKKYYDEEANAPLDDDIDDKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X035</accession>
    <name>C6X035_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781867.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00247"/>
    <dbReference type="EnsemblBacteria" id="ACU06720">
        <property type="protein sequence ID" value="ACU06720"/>
        <property type="gene ID" value="FIC_00247"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00247"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OMA" id="FYELTNF"/>
    <dbReference type="OrthoDB" id="377914at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973531" evidence="1">
        <location>
            <begin position="23"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="532" mass="58567" checksum="5D8EBB7271752061" modified="2009-09-22" version="1">MKNIKKIAFILTAALFTSSAIVSCRQDFNELNENPNNPESPLTYGVFNYANRVVADGTRNSFESARVTLPWMQYSAQTAYNDEDKYAYRLTSGDALWTQLYTAASNYKKVIDMNTDPETAAASSAYGSNANQIAASRVMLSYVFLNLADSFGDIPYYSYGNDDPDFQALNVNEFLKPKFVSQVKVYGDILKELKEASEMIEGSEPVFAPADVLFQGNAGKLKKFANSLRLRVATRVKGVVPGAEAHIADAIAQGVMTSNADNVGVKYENNLTNPSPMYNDFRTRSDFSVSKTFIDLLKGNTGAFGVDPRLFKYATPQGTSKATILNGTYVESTDLTKYVGMPYGLPEDFQASQAVVGNNFFSKYVYRQDYTELFMEYSEVEFLLSEANGWSQTNYQNGVKASMLKWGVTEAAANTFVATLPAATAATVLTQKYVALFMQPYEAWAEYRRTGYPDTSILVLPGETASLLVPIPDTGETTYTFTPLVTGLTDIPARLYYPTVIKTLNPENYASASAALGSGGDKLTTKLIWDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X039</accession>
    <name>C6X039_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">FIC_00251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00251"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="EnsemblBacteria" id="ACU06724">
        <property type="protein sequence ID" value="ACU06724"/>
        <property type="gene ID" value="FIC_00251"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00251"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_10"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="13"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="312"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="197"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU06724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="547" mass="61460" checksum="05F78288507FC182" modified="2009-09-22" version="1">MHKPNLMSKKNTKYIFVTGGVTSSLGKGIVSASLGLLLKSRGFTVSIQKLDPYINIDPGTLNPYEHGECYVTEDGAETDLDLGHYERFLDSPTSQNNNVTTGKIYQTVIEKERKGDFLGKTVQVIPHITNEIKRRIKILGKQNYDIIITEIGGTVGDIESLPYIESVRQLKWELGANNSMVIHLTLLPYLAASGELKTKPSQHSVRQLMESGIQADVLVCRTEHKIPKEQRAKLAQFCNVALENVIECKDLETIYEVPIYLQKQDFDDVVLKALDLKNDKDADLKDWKNFLKRYQNPKRSIEIALVGKYVSLQDSYKSIAEAFIHAGADMETEVRIRWVYSGDLTEENTAETFAGIDGMLIAPGFGDRGIEGKIAAAKFARENKMPLLGICLGMQIMTIEYARDVLGYKKANSVEFDTGTPEPVISLMEEQKNVVDKGGTMRLGAWKCSLKPNSKLHEIYGSKVISERHRHRYEFNSEYKDEFEKSGLMPTGTNPETGLVETLELRDHPFYVGVQYHPEYKSTVATPHPLFKALIKASIKNKEAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X087</accession>
    <name>C6X087_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781919.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00305"/>
    <dbReference type="EnsemblBacteria" id="ACU06772">
        <property type="protein sequence ID" value="ACU06772"/>
        <property type="gene ID" value="FIC_00305"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00305"/>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112632_1_2_10"/>
    <dbReference type="OMA" id="YHGCLVE"/>
    <dbReference type="OrthoDB" id="1858654at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="13918" checksum="0F2CC5CAE7ACFD7A" modified="2009-09-22" version="1">MLSKILLENVKIYAYHGVLPEEKIIGTYYLVNLEVHADLWKATETDDLNDTVNYAEINAIIHEEFKTPSKLMEHVAGRIMGKIKEKFPQIKFIKIKITKTNPPMPGEMHGVSVEFEQDFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A4</accession>
    <name>C6X0A4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00322"/>
    <dbReference type="EnsemblBacteria" id="ACU06789">
        <property type="protein sequence ID" value="ACU06789"/>
        <property type="gene ID" value="FIC_00322"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00322"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2897558_0_0_10"/>
    <dbReference type="OrthoDB" id="2025178at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="62" mass="7405" checksum="01450CAC5691B97C" modified="2009-09-22" version="1">MDQKKSYTFLEIKQKLAAYCSYQDRCHQEVEQKVRDFLLIPEVRSNKISDFTRVKTTSEIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C6</accession>
    <name>C6X0C6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781958.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00344"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06811">
        <property type="protein sequence ID" value="ACU06811"/>
        <property type="gene ID" value="FIC_00344"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00344"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_9_10"/>
    <dbReference type="OMA" id="PITHEEC"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="286" mass="32945" checksum="FB4DDFB4A5343EB3" modified="2009-09-22" version="1">MSVTVAIPFFNAEKYLADSIKSVFAQTFEDWELLLIDDGSTDNSLSIAKSVNDPRVRVLSDGLNKKLACRLNEVTRIAKYDLIARMDADDLMSPNRLKTQIDILNTNPDYDLVTTGVYSVMNDLTLVGKRGSSFKDATFDEIISRKKGVTHAALMARKNWYERNKYDETLTIAQDLDLWVRSSFNNDLKIISVDEPLYIYREEGNVTSAKILRAYKNERRLIKKYVGLLNPIYIKSMMKTLAVTMMDIFSIKRDMQAKRNIEVGPQERYNYEQNVQRVKSIRLPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C8</accession>
    <name>C6X0C8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781960.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00346"/>
    <dbReference type="EnsemblBacteria" id="ACU06813">
        <property type="protein sequence ID" value="ACU06813"/>
        <property type="gene ID" value="FIC_00346"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00346"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_5_10"/>
    <dbReference type="OMA" id="ETHILND"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="91" mass="10123" checksum="64251A4410A116B1" modified="2009-09-22" version="1">MQRALIIEQLKGILKPYTPNPETLQGFSENSNFINDLQINSANMVDVFLDAEDVFNIVLDNESLEQISSVKDAIDTIEKKLQGSEQPLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J9</accession>
    <name>C6X0J9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00418"/>
    <dbReference type="EnsemblBacteria" id="ACU06885">
        <property type="protein sequence ID" value="ACU06885"/>
        <property type="gene ID" value="FIC_00418"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00418"/>
    <dbReference type="HOGENOM" id="CLU_3328168_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="38" mass="4323" checksum="426D6426D0E32446" modified="2009-09-22" version="1">MQEARNTKSVKNNMNLILIPVLSYPVHCPTNTKQPVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L3</accession>
    <name>C6X0L3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782046.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00437"/>
    <dbReference type="EnsemblBacteria" id="ACU06899">
        <property type="protein sequence ID" value="ACU06899"/>
        <property type="gene ID" value="FIC_00437"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00437"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_2_10"/>
    <dbReference type="OMA" id="GNYRAGF"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="18538" checksum="E42833622CA3223A" modified="2009-09-22" version="1">MSAKWNLDPTHSEITFKVRHMMISNVKGEFKEFNVELDTADDTFKSVKVKATVDASSISTNNTDRDNHLKSAEFFNTEAHPQITFESDALTENGSGTLTINGVSKPITLDVDFGGTNVDPWGQTKAGFSFEGKINRKDFGLNWNAALETGGVMVSDEVKIAGELQFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L7</accession>
    <name>C6X0L7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782050.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00441"/>
    <dbReference type="EnsemblBacteria" id="ACU06903">
        <property type="protein sequence ID" value="ACU06903"/>
        <property type="gene ID" value="FIC_00441"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00441"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_1_10"/>
    <dbReference type="OMA" id="RVRDNTT"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="273" mass="30049" checksum="9DF9F39EBE2EDEFF" modified="2009-09-22" version="1">MKTILPGDVSNLQLQTLLQTAIAPRPIALASTVDADGNVNLSPFSFFNLFSSNPPVVIFSPSRRVRDNTTKHTLENVLQVPEVVIGIVNYSIVQQISLASTEYEHGVNEFVKAGLTMSDADLIQPKLIGECPVNLECKVLEVKPLGTEGGAGNLVISEVIKIHIREEYLNDDGNLDQKKLDLVARLGGNWYSRNNAENLFEVPKPLLTKGIGFDQLPDAIKFSKVFTGNHLGMLANVEALANGNFTADENLHRKAQEFLFQNNVNEAWRILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Q3</accession>
    <name>C6X0Q3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA recombination and repair protein RecO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00477"/>
    <dbReference type="EnsemblBacteria" id="ACU06939">
        <property type="protein sequence ID" value="ACU06939"/>
        <property type="gene ID" value="FIC_00477"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00477"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087596_1_0_10"/>
    <dbReference type="OMA" id="TKYLGFY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="230" mass="26002" checksum="878B3EF6BB628456" modified="2009-09-22" version="1">MMQNQVCFLLSYIKYGDNDAVLHCFSKDAGYQSFFARGIYSARNKKKAYLFPLNQIGITVVPRRNSGGIPTISKIEMVSQDYDFADVKVNTVLLFVADFLNQVLREETHHSNTYSEIGRFLNALYSGDLGAYTAFIFKILSCQGLSPLPGDGNYLDPESGTFSASQTHSFFTEEISAVWKQLASAADIYDVALKRPLRRSFLDSLMLYYKFHVTGFSEPNSLEIIHQVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X6</accession>
    <name>C6X0X6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08089">
        <property type="protein sequence ID" value="ACU08089"/>
        <property type="gene ID" value="FIC_01644"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01644"/>
    <dbReference type="HOGENOM" id="CLU_3343948_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="37" mass="4095" checksum="891FA966C816C8D2" modified="2009-09-22" version="1">MGAHFRLSLLASRVPCGPRESSDRPFNPGRNPLSKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X132</accession>
    <name>C6X132_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806430.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01702"/>
    <dbReference type="EnsemblBacteria" id="ACU08145">
        <property type="protein sequence ID" value="ACU08145"/>
        <property type="gene ID" value="FIC_01702"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01702"/>
    <dbReference type="eggNOG" id="COG3685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102561_2_0_10"/>
    <dbReference type="OMA" id="IYYAENQ"/>
    <dbReference type="OrthoDB" id="1739824at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="2">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="20483" checksum="555FCD9E08A5573C" modified="2009-09-22" version="1">MDNTKGNSRGQSTRKVEAKSSAAEGLRELFVDELKDIVYAERALLKALPKMANNATEPKLKMAIEDHIAVTEGQVQRLEQIFEILGESNRGKKCDAMEGLIKEGESIMEETEQGPVRDAGIISASQKIEHYEIASYGTLAAFANTLGETEIVSLLEATLAEEKEADALLTESAYNSINFEAAEEDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X172</accession>
    <name>C6X172_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor, plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806470.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01742"/>
    <dbReference type="EnsemblBacteria" id="ACU08185">
        <property type="protein sequence ID" value="ACU08185"/>
        <property type="gene ID" value="FIC_01742"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01742"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OMA" id="NPKYGST"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973328" evidence="5">
        <location>
            <begin position="29"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="52"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="433"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="955" mass="105298" checksum="1DC0F1C41A1A60C5" modified="2009-09-22" version="1">MNRFSFAGTNRAAVFFAMALLPSGLVYAQQDTLAKEQKIEEVVVIGYGQQKKEAVTGSVSSLSGSALKEVPASNITEALSGRLPGVEIGRLSTKPGAEQQIRIRGTRSLSASNNPLIVLDGIPFAGSIEDINPNDIKSLDILKDASATAIYGSRGANGVILITTNRGTKNQKARLTYNGYSGIQTIFSKYPMMDGEKFTKLKADAKLYPSLGSDEQFGLNTDWQDLYYTPGMISSHDVGLSGGSETGSYSTSLAYFNQEAVIPLQNYERFSLRSSIDQQIGELLRVGVTTNNNYSVTNGRGLNAGAVLQYTPISNPYRPDGSIKSLLNTSADQNWLYSRETLEALGNKYVDQNRAFSSYNNLYAELAIPGIEGLKYRLNAGLNYRVSNRGGYTGMGVFNTNPLAVSSASIGATHMTQWVLENILTYDRTFGKHKINGTALYSAEQTTFNSSFVRATDVPIDAFQFYNLGHAQGEITINPADQNYYKRGLLSYMGRILYQFDNKYMLTATLRSDGASVLAPGRKWHTYPAVSVGWNATNESFLSDVKNVDLLKFRVGYGETSNQSVDPYSTWGRLGTIPYNFGDGGAGSYEIGNYVTQLPNANLGWEFSETWNYGLDFGFFNNRLTGTVEYYKTNTVDLLLAKRLPTTNGVETVIQNVGETENKGWEVSLNGSIIKTEDFSWNVGVNFYTNENKIVKLNSGQLRDEGNFWFVGHNVNSLYDYQYVGLWQEGDPHLNILEPGGNVGMIKVLYTGEYNADGTPVRAIGADDRQVIDTDPDWLGGFNTRWTYKNFDLSAVGAFQHGGVLVSTLYGSSSYLNMLNGRRGNVDVDYWTAENPNVRYPKPGGVASNDNPKYGSTLGYFDGSYLKIRTISLGYNFEKSLIDALNMSGLRLYVTVQNPFVLFSPYHKESGMDPEPNSMGNENQAVTTAYQARMRVIGTNNPSTRNYLMGINLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G4</accession>
    <name>C6X1G4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase, family 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01834"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08277">
        <property type="protein sequence ID" value="ACU08277"/>
        <property type="gene ID" value="FIC_01834"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01834"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044973_3_0_10"/>
    <dbReference type="OMA" id="GSYNVGM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="290" mass="34594" checksum="5D9BE33A1D2275AF" modified="2009-09-22" version="1">MHFMAKKTTKRKTTRKIHKNRRRHFLLRREILLVILAAALLGTGFYLKQKIAFYYAMYFNKFEHKTLSNTEFEENRINRIIADYNDKTFGIDMSHYQRKEDIAWDSLSIANRAIPIEFVVLRATMGNRSSDRNFDDFWQLAKQHQLIRGAYHFYRADEDPVRQANNFLENVKLEEGDLPPILDIEKVPKRKSNAKLVEDLKIWCRIVEETYGEKPIIYTYYHYYNDFLKGEFDDYPLWLANYNDVPQPAPHANWDIWQFTENGIVYGINTKVDVNVYNGSLWSLKRLTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1N1</accession>
    <name>C6X1N1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806629.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01902"/>
    <dbReference type="EnsemblBacteria" id="ACU08344">
        <property type="protein sequence ID" value="ACU08344"/>
        <property type="gene ID" value="FIC_01902"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01902"/>
    <dbReference type="eggNOG" id="ENOG5033JH2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2791335_0_0_10"/>
    <dbReference type="OMA" id="MNYIGND"/>
    <dbReference type="OrthoDB" id="1983182at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="67" mass="7727" checksum="FB3B78B74E86BAF2" modified="2009-09-22" version="1">MNIRSTKYYIVAALTFIILFLMNYIGNDLPDRLERALMTAVAGVIGLTIGMWFVYRNAKDDTHHDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P7</accession>
    <name>C6X1P7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806645.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01918"/>
    <dbReference type="EnsemblBacteria" id="ACU08360">
        <property type="protein sequence ID" value="ACU08360"/>
        <property type="gene ID" value="FIC_01918"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01918"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527616_0_0_10"/>
    <dbReference type="OMA" id="FAYPNNY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="513" mass="60294" checksum="DE1427DF0014648C" modified="2009-09-22" version="1">MAKLIWIDDEVDLLKPHIVFLENKGYKVSPVNNVNEALEMIEKENFQLALLDENMPGISGLEAIPMIKNIDSAIKIVMVTKNEEEHIMEEAIGSQIADYILKPVNPNQVLLSLKKNLQEDTLVEQKTILQYQQEFRNLSMELSYMRSYQDWAEYYKKIVNWEIKFDKVSDNEFSDLLQSQKEEANIQFSKFIENNYEEWLHGGEKPMMSHTLFKDKIKTEVEKEKVLLLMIDNLRYDQWKVIEPLFTKFYNKTSEDYYFSILPTATQYARNSFFAGLLPSEIEKRFPNYWFNDNEEGNKNEHERDFLEDQMKRLGLSGKSMKYLKILNADFERKVLDDFNQHKSNDLLVIVYNFIDILSHAKTDNVIVNQLIRDDKTFRSLTYNWFENSSLLKIIKQAAENGYKLVITTDHGTIYVKKPSKVVGDRETSTNIRYKTGRSLTYENSDVWAISNPEKLFLPKGNLSSKYIFAKNNIFLAYPKNYNHFVNYYKETYQHGGISLEEVIIPISILEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q4</accession>
    <name>C6X1Q4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806652.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01925"/>
    <dbReference type="EnsemblBacteria" id="ACU08367">
        <property type="protein sequence ID" value="ACU08367"/>
        <property type="gene ID" value="FIC_01925"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01925"/>
    <dbReference type="eggNOG" id="COG3685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102561_2_0_10"/>
    <dbReference type="OMA" id="AKTCEAM"/>
    <dbReference type="OrthoDB" id="1739824at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="2">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="175" mass="19049" checksum="5F2F3D4E2F24BD3E" modified="2009-09-22" version="1">MAKTATDKIKPATDAAESLREFLVDGLKDLYWAEKALAKALPKMAKNATSPKLQQALTKHLEETQNQATRLEDAFKALGEKAKAEKCDAMDGLIKEADDIMKETEPGPVRDAAIIAAAQKVEHYEIASYGTLATYAKLLGEKEALDLLKATLAEEKTCDTDLTKLAVSEINLKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R0</accession>
    <name>C6X1R0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01931"/>
    <dbReference type="EnsemblBacteria" id="ACU08373">
        <property type="protein sequence ID" value="ACU08373"/>
        <property type="gene ID" value="FIC_01931"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01931"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_0_10"/>
    <dbReference type="OMA" id="ASWTYYK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="147"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="348" mass="39460" checksum="32B8A7F5DBFE0313" modified="2009-09-22" version="1">MIYLFTEYRLLLMLQTLKIAILGYGHIGKKHADMVAQSEDCELVALIDPKFITDDYAGLKTPPYFLSLQEFLDSGIKADIVAVCTPNGLHYEQATLLVMHGIHVIIEKPISLKSEEAELLEKLASEKQVNIFPVMQNRFSPPAVWLKNLIDANALGKIYMVQISCFWNRNEHYYEKGSWRGTKNLDGGTLYTQFSHYLDIMFWLFGDITNIKSKFADFNHSHLTEFEDSGIITFDLKSGGMGSFTFSTSVWNENLESSLTIIAENGSVKIGGQYMNKVEKCIIKDYIEPELPETSSANDYGSFKGSAQNHHHLYQNVIDFLNNGKQIQTTTDDCVKVLKMIEEIYASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S5</accession>
    <name>C6X1S5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide export outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01946"/>
    <dbReference type="EnsemblBacteria" id="ACU08388">
        <property type="protein sequence ID" value="ACU08388"/>
        <property type="gene ID" value="FIC_01946"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01946"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038343_1_0_10"/>
    <dbReference type="OMA" id="TSFWISL"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="29229" checksum="AB1D5A29B4AFDBD3" modified="2009-09-22" version="1">MLKMNRNLFILLISAISFLSSCKPQEKTSKLNYMQSVEELATQAAANNAQSTIQIADQLIIFVSAKNMEVVRPFNQNYYNNQTPGSVSTANSEKTYLVDSEGNISFPVIGKINTVGKSLEQLRNEITTEVSVYVKEPTVALRLANFKVTVLGEVNRPGQYTIPEGQTTLLNALGLAGDLTIYGERENILMVRNTNGSLSKERLNLMDADFINSPFFQLKQGDVIYVSANETKEKLSRQDPNTGIYIAVAGTIIGLAGIFITIFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T3</accession>
    <name>C6X1T3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806681.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08396">
        <property type="protein sequence ID" value="ACU08396"/>
        <property type="gene ID" value="FIC_01954"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01954"/>
    <dbReference type="HOGENOM" id="CLU_2632849_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="77" mass="8190" checksum="DAE7D77AC643E58E" modified="2009-09-22" version="1">MVVSFDGKFSAFFGTGSWTVYANTGAGNSFQNLGDLQLLSLFGSTATDSFAVALPTGANNKTDLKIRIEVYLGLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U4</accession>
    <name>C6X1U4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="2" type="ordered locus">FIC_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806692.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01965"/>
    <dbReference type="EnsemblBacteria" id="ACU08407">
        <property type="protein sequence ID" value="ACU08407"/>
        <property type="gene ID" value="FIC_01965"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01965"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_2_2_10"/>
    <dbReference type="OMA" id="WRGAKTA"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="25998" checksum="19B7469735EAFEBD" modified="2009-09-22" version="1">MGKNKQARFDENRILPNVFQPTREEAQQGYHLKGKWRSEVFKNDHPVVLELGCGKGEYSVGLAKAFPEKNFIGVDIKGARFWFGAKEALEENLNNVAFLRTQIELIDGFFAADEVDEIWITFPDPQIKFRRTKHRMTNPEFLARYQKILKKDGIMHLKTDSEFLHGYTLGLLQGMGHEIISAHHDIYGAPEFDPDTPLLREIKTYYEGLFSAKGKTITYIKFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W4</accession>
    <name>C6X1W4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806712.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01985"/>
    <dbReference type="CAZy" id="GH92">
        <property type="family name" value="Glycoside Hydrolase Family 92"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08427">
        <property type="protein sequence ID" value="ACU08427"/>
        <property type="gene ID" value="FIC_01985"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01985"/>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_2_2_10"/>
    <dbReference type="OMA" id="MGHTFPG"/>
    <dbReference type="OrthoDB" id="100818at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973610" evidence="2">
        <location>
            <begin position="21"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="4">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="3">
        <location>
            <begin position="289"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="757" mass="86405" checksum="74C94F037CD4E7EF" modified="2009-09-22" version="1">MTKFLTLFSISLLITMNAQKLTSFVNPFVGTKNMGHTFPGATAPFGMVQLSPETNQVPYAVDGKYNPETYRYCSGYQFEDETIFGFAHTHFSGVGHSDLGDFLVMPTTGELNLEPGKINEPKSGYHSRFSKDTEKAEPGFYEVFLDDYGVKAELTSSERVGFHRYTFPKSGESHIILDLMSNIYNYDGKNVWTFVRVEDNQTVVGYRETTGWARTKKVFFAMKFSKPFKNYGRKRYEKVEYNGFYRKFNENENFPEFAGRQIRAYFDFATEQDEQILIKFALSNTSTNGALKNLEAEIPHWNFDQVKAETSGKWGKELSKIEVETLNENDKKTFYTALYHTMMSPILYEDVDGKYLGLDQNIHESEGFTNYSIFSLWDTYRALHPLYNIIQPKRNNDFIHSMMAHHDQSVHKALPIWSHYANENWCMIGYHSVSVIADAIAKGTTNIDVSKALAASKTSSNLKYYDGIEDYLKYGYVPEDKSSSSVSKTLEYAYDDWAIAQIAKKAGDKNAEAEYLKRSESYKKVYNPKTGFMHPKLSDGTFKKDFDPMDTHGQGFIEGNAFNYGLYVPQNVPEMIKLMGGKQKFSKHLDEIFTTEIADKYIEKNEDITRDGIIGNYVHGNEPGHHIPYLYNWTGDAWKTQERVRLIMRKMYSAEEDGLCGNDDAGQMSAWYVFSALGFYPVLPGSDEYQIGSPLVKSAKINLENGKTLSIKTENQSEKNVYVKRVLVNGKELKNHVLKHSDIANGGEIVFVMSNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W6</accession>
    <name>C6X1W6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylglutaconyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.18" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806714.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01987"/>
    <dbReference type="EnsemblBacteria" id="ACU08429">
        <property type="protein sequence ID" value="ACU08429"/>
        <property type="gene ID" value="FIC_01987"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01987"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_10"/>
    <dbReference type="OMA" id="HPAHNSL"/>
    <dbReference type="OrthoDB" id="1114675at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004490">
        <property type="term" value="F:methylglutaconyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="255" mass="27489" checksum="18E66BFA1048074E" modified="2009-09-22" version="1">MNNGFVNHEIKNNIAEITFGHPKSNSLPGEILEKLAQTILQTGKDAAVKAILLKSDGEKAFCAGASFDELLSIEELEASTKFFGGFAKVLNAMRNCGKLVIVRVQGKTTGGGVGIACAADYCFAVENAAMALTELNLGIGPFVIGPYVERKIGNSAYAAMSIDADFRSANWCEKHDVYHSVSPTIAEMDAKLDEFLAALSVRSTDALALIKKVSWEGTEHFESLMPERIHMSASLILEDSAKKSIEEIKARLSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y2</accession>
    <name>C6X1Y2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="8" type="ordered locus">FIC_02003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806729.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02003"/>
    <dbReference type="EnsemblBacteria" id="ACU08445">
        <property type="protein sequence ID" value="ACU08445"/>
        <property type="gene ID" value="FIC_02003"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02003"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_1_1_10"/>
    <dbReference type="OMA" id="GKQNQRD"/>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="58" mass="6405" checksum="367F0FD860E828A4" modified="2009-09-22" version="1">MAKIQVKQVKSAIGRTKTQKRTLEALGLKKLHQVVEHDDTPSILGMVSAVSHLVEVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z1</accession>
    <name>C6X1Z1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ordered locus">FIC_02012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02012"/>
    <dbReference type="EnsemblBacteria" id="ACU08454">
        <property type="protein sequence ID" value="ACU08454"/>
        <property type="gene ID" value="FIC_02012"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02012"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_10"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="84" mass="9863" checksum="CE1CDA30DB23C2EB" modified="2009-09-22" version="1">MDRNLRKERIGIVSSNKMEKTIVVSETTRVKHPMYGKFVLKTKKYTAHDENNECTEGDTVLITETRPLSKSKRWRLVRIIEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z7</accession>
    <name>C6X1Z7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplB</name>
        <name evidence="7" type="ordered locus">FIC_02018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806744.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02018"/>
    <dbReference type="EnsemblBacteria" id="ACU08460">
        <property type="protein sequence ID" value="ACU08460"/>
        <property type="gene ID" value="FIC_02018"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02018"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_10"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="273" mass="29938" checksum="E990A629EAD86390" modified="2009-09-22" version="1">MSVRKLKPITPGQRFRVVNNFEEITTNKPEKSLTVGISKSGGRNNTGKMTMRYTGGGHKQKYRIIDFKRNKFDVEATVKTVEYDPNRTAFIALLEYADGEKRYIIAPNGIKVDQKVISSETAEPNVGNAMKLKNVPLGTVVSCIELRPGQGAVMARSAGSSAQLTSRDGKYAIVKLPSGESRMILTECMAMIGSVSNSDHQLTVSGKAGRSRWLGRRPRTRPVVMNPVDHPMGGGEGKSSGGHPRSRNGMPAKGYKTRKKNKASNRFIVSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X277</accession>
    <name>C6X277_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB dependent receptor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02103"/>
    <dbReference type="EnsemblBacteria" id="ACU08540">
        <property type="protein sequence ID" value="ACU08540"/>
        <property type="gene ID" value="FIC_02103"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02103"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_10_0_10"/>
    <dbReference type="OMA" id="GWFGDGN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="69"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="212"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="679" mass="77037" checksum="C6C336AA9316C01F" modified="2009-09-22" version="1">MTPIKYSAFKGLNRYATALLLFPCIHILAQTHAHDSLAYRDIEVVKIIKIATGDKNKSKISTSNTDLLNHDAGKFLSSIPEISGIKKAGNYATDPVLRGFKYEQLNIVIDGAANAVNACPSRMDPAVSQVNMNMVQEAEIFKGPYHFRNGNSFGGTINFVTLKTVFTENPTFGGRISTGFESNGNIFRNEAFTELTTKKMVWNLFGSYQKGDAYKDGNGDEVRSAFLRYNIGTKGSFKWNENNITTLQVNTNQGRDVEFAALQMDLIYDKTWMYQLKHLAEFENSFFNQVDFNSYYSVVDHSMGTADRSMVSDVKSLTFGGRGELKKTWNNHILYTGLDYKHEAAENLRMVMPMMMGMKPRDGSSWQDSEVSQIGWFGEYQYRFPDAKLTASARIDYNSSDANKPSQLFQNLYGDLSSENWNSNFSLGYSRSLGKDSQIALWTGRAQRSGSLTERYINLFAVGNDNYEVLGNPHLKPETNNQADLIYTFSREKVFVQANVFYAYLENYISGVIRPDIMPATMKSPGVRQMQNLGNAMKAGFESRVNWQVLPKLRSEMAVAYTYAEDLDTKRPLPEIFPLDFRWKLQADLSPVIIVVNYRYSAAQNRVADTFGELRTPDFSLFNVNLKYNVFRNASIDAEVNNVFDNAYAEHLNRTLSTDRNSRILERGRSFNLGFTYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B7</accession>
    <name>C6X2B7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accA</name>
        <name evidence="12" type="ordered locus">FIC_02144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806864.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02144"/>
    <dbReference type="EnsemblBacteria" id="ACU08580">
        <property type="protein sequence ID" value="ACU08580"/>
        <property type="gene ID" value="FIC_02144"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02144"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_10"/>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="318" mass="35852" checksum="2F35EE0ABEAD8B7B" modified="2009-09-22" version="1">MEYLNFELPIKELMDQYQTCSLVGEESGVDVKLACSQIEDKIIEKKKEIYGNLTPWQRVQLSRHPDRPYTLDFIKGIVDKDSFLELHGDRNFADDPAMIGGLATLDGQRVMIIGTQKGRTTKERQHRRFGMSNPEGYRKALRLMKLAEKFKIPVISLIDTPGAYPGLEAEERGQGEAIARNIFEMTMLKTPIFVYIIGEGASGGALGIGVGNKVYMLENTWYTVIAPESCSSILWRNWDHKEDAANALKLTPQDALREKFIDGIIEEPLGGAHYEPQVAYDHLKTSILQNIKAFSAFTGKELETQRQDKFIAMGQFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C8</accession>
    <name>C6X2C8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02155"/>
    <dbReference type="EnsemblBacteria" id="ACU08591">
        <property type="protein sequence ID" value="ACU08591"/>
        <property type="gene ID" value="FIC_02155"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02155"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094155_0_0_10"/>
    <dbReference type="OMA" id="DPRWDKL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="20512" checksum="65604EA9EC54B681" modified="2009-09-22" version="1">MHTQFMDRLRNYDIVFSGQKNGKHQFRFEIDKAFFQLFDTEQEFTEPEIVADILMDKHTTFLELNIKTAGTVNLVCDITTDTFSHPVENELNVLVKFGTEYDDSEEDVITIPSSDHAFNVAQLIYESVMLAIPMKKISPNISDEDLEILDKFSPKDEVEEEETDPRWEALKKLKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D1</accession>
    <name>C6X2D1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806878.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02158"/>
    <dbReference type="EnsemblBacteria" id="ACU08594">
        <property type="protein sequence ID" value="ACU08594"/>
        <property type="gene ID" value="FIC_02158"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02158"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043647_0_0_10"/>
    <dbReference type="OMA" id="MPAQQNE"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="276"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="484" mass="55621" checksum="607AFAA97B9C8BDD" modified="2009-09-22" version="1">MPFSKYKGYSLRNKVFWGFLTICLLSIVSSSILSYFILRNNAVQQSQTDLQKKSESLMSALDYSVSHIQVDSKDLPKILTNDIFEIADINNQDIIIYDLSGKFLISNKDINLIAQKKIPIDVLNTVLKKDGRVDFLTYDQNIDANVTSSYTILKNNMLQPIGIVYFPYYHNDSSYFSVFNKYLNYILIVNLLIIALAVWLSWIISNNLTKAVTRFSDMVNKITLFEKDLQPIRYYQNDELNQLVKAYNKMILQIKEQKERLSFREKEEAWREMAKQVAHEVKNPLTPMKLTIQNFERKFNPEDPDIHNKVKTLSKTLVEQIDLVATVASAFSQFAQLPEKNNEMFDINKEIRNILNVFSDPGIYFHSNKTSIMVEMDKNYLSGIITNLVANARQARGDDQESPINVDVEQRQKRVTITVQDNGTGIPEELFDRIFEPNFTSKTGGTGLGLTMVRKMVEDYRGDISVESETGKGTTFIIHLPTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G7</accession>
    <name>C6X2G7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02195"/>
    <dbReference type="EnsemblBacteria" id="ACU08630">
        <property type="protein sequence ID" value="ACU08630"/>
        <property type="gene ID" value="FIC_02195"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02195"/>
    <dbReference type="HOGENOM" id="CLU_3118085_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="50" mass="5969" checksum="56322F414C0E5F52" modified="2009-09-22" version="1">MGRINEKTVRLHNENTFIFKFSPSNKMPTKRNLTYSKFPIGQRNQAEFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2I5</accession>
    <name>C6X2I5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806932.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02213"/>
    <dbReference type="EnsemblBacteria" id="ACU08648">
        <property type="protein sequence ID" value="ACU08648"/>
        <property type="gene ID" value="FIC_02213"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02213"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035309_1_1_10"/>
    <dbReference type="OMA" id="RSPALWM"/>
    <dbReference type="OrthoDB" id="1809199at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="381" mass="42376" checksum="40C2C46821334A96" modified="2009-09-22" version="1">MLSTPQKQRIALSAYFLLSGICFSSWASRIPTLKTNYNLSEEDLGNLLMIMPASAIIGIPLSGWLVAKFDSRTPLQIASVAFLLSLFALSWDLSIIGIAVSLVFFSVALRIINIAINTQSLAIQQKFEKKIVGSFHGVWSIGGILGVLFSTIMLKYNISIFWHFLFVALFGSLIIFTMFPFLIKNDKAKVSAKFKLEKPSRYITLLGLMVFFAAICEGGMYDWNGVYLKEVVNQEVFTYGYLLLMICMTISRLTIDRLMERFGMQKLYITGSVTVMLGVLIAVLFPSLYPVLIGFCMIGFGISGLYPMTFILAGKSKKYSIAIVMSIISTYSTVGMFLGPPLIGYLAHAFGLQKAFITFIIAGFMFIPLSKMVFSHLKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J9</accession>
    <name>C6X2J9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2807 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02227"/>
    <dbReference type="EnsemblBacteria" id="ACU08662">
        <property type="protein sequence ID" value="ACU08662"/>
        <property type="gene ID" value="FIC_02227"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02227"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653373_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025348">
        <property type="entry name" value="DUF4252"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14060">
        <property type="entry name" value="DUF4252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972245" description="DUF2807 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2807" evidence="3">
        <location>
            <begin position="200"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="420" mass="45253" checksum="47E8A5C9AAE9A684" modified="2009-09-22" version="1">MKKIILIFALFFSFANVSAQKDKLDQLFEKYQETEGVTSIKIAKPMFNMLNKLNINDSELDQIKPLLSKINGLKILIVEKPETPTTPGTDNKKELDLFQNLQADISNSIKNMRYEELMTVNSKDNKIKFLSSDATNGILDNLLLSINSEGNTVLMMLDGKISMDDVNNLVNEAQNVSLKSSLTTENLSIGGNTQVRKVGKFTGIKVSSGIKVNFTQGNNQSVIVDTDANLQQYISTEVVNDILVISVDNRNNKKLNFKKLLVTVEAPRLTWVDVNSGAQFNTLNTIKEDTFRAEVSSGANLNAEVAARNAVDLEITSGSSAQLDIESGSFNMAGTSGSSSTIRGKANSANFKLTSAASCNAADLVTQNATVSATSGSSLRVHTTDSITGTATSGASIRYKGDPKNTSGTKTSSGGSFKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L8</accession>
    <name>C6X2L8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02248"/>
    <dbReference type="EnsemblBacteria" id="ACU08681">
        <property type="protein sequence ID" value="ACU08681"/>
        <property type="gene ID" value="FIC_02248"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02248"/>
    <dbReference type="eggNOG" id="COG0729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030171_1_0_10"/>
    <dbReference type="OMA" id="NIFKQDS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="546" mass="63350" checksum="93D08CF3942F0C2B" modified="2009-09-22" version="1">MRKLSSNCEPSVLRRSLFIFFAFASVFFKAQDKEFWLIDTVTNQTKIVKDSLSAVKFLDSLSQNNYYQTELKQVVQKENHTEIFFDKGKNFNQAHVQLTDETAKLLKSENRFFTENLDSLKQVININYRQRGYAFNRVKSNFLGMQAGVPKVEISVVEGGQRKIDSFEVRGYEKVPKRFIKNLEKEFQGKIYEDQNLVRLSQSLQNHPFVLLDKPPQTLFTKDSTQVFLFLQKKKSNSFDGIIGFGNDKSEKFTFNGSLNVNFRNMFNSFETVNIFWQRNPDRGQTFDLKTDIPYLFKSNIGLNMNVNVYRQDSTFANVKFLPGLYLHLSNRQKLGLRGTFETSSVIDSLYTQGRDYGKKGIGVWYDFTEPTDVELFLYKTRIRAEADLISTRYPEENTTVQQNNFFFLGERNFHIKGNHYLNLKAETALMSSKNDLAANELLRFGGWNSMRGFNENTLLADFYYFATAEYRYLVGNQAFFDIFGQYGELNNQSLESKPKLYSFGLGFNFFLPVGLMSFQISNGSQFGNPVKFGDTKIHWGILSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T2</accession>
    <name>C6X2T2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02312"/>
    <dbReference type="EnsemblBacteria" id="ACU08745">
        <property type="protein sequence ID" value="ACU08745"/>
        <property type="gene ID" value="FIC_02312"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02312"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025041_0_0_10"/>
    <dbReference type="OMA" id="DVRYFTK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025631">
        <property type="entry name" value="Porin_10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14121">
        <property type="entry name" value="Porin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973635" evidence="1">
        <location>
            <begin position="30"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="655" mass="74987" checksum="9C126A46C62F002C" modified="2009-09-22" version="1">MPIFLTFVHQSSRMKYFLLCLFFCGYALTAQVVNKTDSNRVKPQDTLVIDSGRKDSLVIFKPTIYDYTYRTQFTEKKIFDTAFTPEKTFVFTQYNNRDNFGRIQFANIGSGFQPLVFEVNPEQNLSLLPTNKSYIIQGIKDVRYYDVKTPTTAFIYHNSVSSGAALQTTYTQNIGKNFNFAVEYMGLRSLGMYQNNLAANNNVIFSGHYISKNNKYEAFAHFIHQNVNNEENGGIADINLFLGDNNNFDNRLNLPVNLNASESRFSYRRYYFSHQFRPFASEKFPFKIRHTIFHQGNKYYYTQSAPETFYFDDGSELIDYPLSSKKYSKNLSNTVSVLFDKENFKLDAGVRHQIINLGVGAALPASVNIPEQLSENRLGAVGNLQIRLWDKVALNSNLEISGGTEFGSFLRSENLLKFEPLPGYFVDAKVNFQTASPDFNLLLNPSVYRKYNYYLEDPANEAITEIGGSVNLKWFKSSVFANYFRIDNYTYLDASALPQQSASSLNISQIGGEATFSYGKFHFNPRLHFQSAIGNSDLLPMPNFIGRANLFFQSKAFKDAAEIQTGIKAYYFTKFASREFFPMLNEFILPGTDSYSIGGQPIIDVYFNLKVKRMFFFIEAQHLNTTLMQNKSFAAPNYPVSDFRLNLGIVWYLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U1</accession>
    <name>C6X2U1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="4" type="ordered locus">FIC_02321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807038.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02321"/>
    <dbReference type="EnsemblBacteria" id="ACU08754">
        <property type="protein sequence ID" value="ACU08754"/>
        <property type="gene ID" value="FIC_02321"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02321"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_3_1_10"/>
    <dbReference type="OMA" id="WKAREPK"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="155" mass="17634" checksum="BBD49DE63D9734B1" modified="2009-09-22" version="1">MDFRTKIEELLHGFLAERPDLFLVDLKFSAGDDITVILDGDSGVTLQDCLDASRAIEFNVDREEHDFALQVMSAGLSEPLVSPRQFRKNIGRELDILMKDSTQIEGELSKVDEDKITLVLQYRKPKEIGKGKMDVTEEKEILYTDIKKALVTIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y1</accession>
    <name>C6X2Y1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807078.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02361"/>
    <dbReference type="EnsemblBacteria" id="ACU08794">
        <property type="protein sequence ID" value="ACU08794"/>
        <property type="gene ID" value="FIC_02361"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02361"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_0_0_10"/>
    <dbReference type="OMA" id="LLDVRWQ"/>
    <dbReference type="OrthoDB" id="920668at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="166"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="280" mass="30464" checksum="4E46EAB01FAB48EC" modified="2009-09-22" version="1">MDISPIISAQGLADLIGTKNLVIADAGSGTEARERYVKEHISGSHYVDLNEDLAEVPADAKNGGRHPLPSLDKFAALLARLGIRRESHVIVYDDKNAANAAARFWWMLRAAGYTKVQVLNGGLPEAIKHGITVNAEIPKVADTELPALKTWSLPTIDLGGVDAFSKNSEALIIDVRENERYRGETEPIDLVAGHIPSAINLPLKNNLDGDGKFKNPEVLKAYFTEILGDHLTENIAVHCGSGVTACHTLLAMHYAGLSIPKLYVGSWSEWSRNFKPVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y9</accession>
    <name>C6X2Y9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_02369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807086.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02369"/>
    <dbReference type="EnsemblBacteria" id="ACU08802">
        <property type="protein sequence ID" value="ACU08802"/>
        <property type="gene ID" value="FIC_02369"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02369"/>
    <dbReference type="eggNOG" id="ENOG5030PDV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104228_0_0_10"/>
    <dbReference type="OMA" id="RVIEGCN"/>
    <dbReference type="OrthoDB" id="1589683at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026323">
        <property type="entry name" value="Exosortase-related_prot_XrtF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04128">
        <property type="entry name" value="exoso_Fjoh_1448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="180" mass="20734" checksum="F5EC9DBEF59624F7" modified="2009-09-22" version="1">MFNDFKPVLKILLRFVVIYVLLVLGYQFYLNFYENSGLDPISVWVADQTVFIQNSFNYPSQMVPGTPEQQTSWFYVSGKYVSRMVEGCNAVSVMILFLAFILAFYQGTKTFIFAAAGLVFLHIINVFRIAGLNILLVELPQYSKIGHDYFFPAIIYGSVVIFWLVWINYFALKVPRNETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X313</accession>
    <name>C6X313_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mn-dependent transcriptional regulator MntR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02393"/>
    <dbReference type="EnsemblBacteria" id="ACU08826">
        <property type="protein sequence ID" value="ACU08826"/>
        <property type="gene ID" value="FIC_02393"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02393"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_0_2_10"/>
    <dbReference type="OMA" id="HGHPIPG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="218" mass="25202" checksum="9913B93FD57530EA" modified="2009-09-22" version="1">MLISLTEENYLKALFHLINADSTVTVNEMSKFLDVKMPSVNNMMKKFADRKWVIYENYKPLKITDEGKKQAALVVRKHRLTEMFLVEKMNFGWEDVHEIAEQLEHIHSDMFFDKMDEILNYPKTDPHGEPIPDKDGNIIAQHLKKLSDCTVEQKVVFTAVTISDADFLSYLTAKNLELGKEIEVLGIEKYDRSMTVRIDSDTAVLSKMICEKILVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X314</accession>
    <name>C6X314_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low-specificity L-threonine aldolase</fullName>
            <ecNumber evidence="4">4.1.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.2.5" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807111.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02394"/>
    <dbReference type="EnsemblBacteria" id="ACU08827">
        <property type="protein sequence ID" value="ACU08827"/>
        <property type="gene ID" value="FIC_02394"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02394"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049619_1_0_10"/>
    <dbReference type="OMA" id="ETDCEVF"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="343" mass="38285" checksum="18B6543381212B8C" modified="2009-09-22" version="1">MKYSFKNDYAEGAHPRILQALADTNFAQQNGYGLDEYSLNAAKLIQDRMASANSAVHFVSGGTQANLIAISAFLKPHESVVAAETGHIFTNESGAIEATGHKVHGVITEDGKLRPADIQQILDSHQNIPHQVKQKLVYISNSTEIGTIYSKHEIRELHLFCREKNLFLFLDGARLGNALTAETNDLTLEDVARYTDAFYLGGTKNGALIGEAIIINNAALQHEFGFHLKQKGAMLAKGRLLGIQFQELFRDGLYFDLAEKANRQAMKIKTALKESGFDFLAETYTNQIFPILNNDQIELLSSDFDFYIWKKLADNRAAIRLITSWATPDEMVNKFIAKIKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X316</accession>
    <name>C6X316_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02396"/>
    <dbReference type="EnsemblBacteria" id="ACU08829">
        <property type="protein sequence ID" value="ACU08829"/>
        <property type="gene ID" value="FIC_02396"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02396"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_10_1_10"/>
    <dbReference type="OMA" id="GILDMIH"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="276" mass="30611" checksum="3A02A279A73DD2A9" modified="2009-09-22" version="1">MINNNRIMSYGLLKGKKGIIFGALNDQSIAWKVAERCHEEGAEFILSNAPIAMRMGEIDELAKKTGSDVVAADATSVEDLEKLFAHAQEKYGKIDFILHSIGMSVNIRKGKSYTDLNYDFLEKGWDVSSVSFHKVMKAAWDKDIMNEWGSILALTYIAAQRTFPNYGDMADNKSYLESIARSFGYYWGDRKVRVNTISQSPVMTKAGAGVKGISGFFNFADSMSPLGNADAVDCANYCVSLFSDLTRKVTMQNLFHDGGFSNTGVSQKIVDKFEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X325</accession>
    <name>C6X325_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OprM-like outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02405"/>
    <dbReference type="EnsemblBacteria" id="ACU08838">
        <property type="protein sequence ID" value="ACU08838"/>
        <property type="gene ID" value="FIC_02405"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02405"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_13_3_10"/>
    <dbReference type="OMA" id="AANQDYY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="481" mass="54147" checksum="89B5572BEA4E5CA2" modified="2009-09-22" version="1">MVQCFKIKKKMKHQFKLYKLIWTLTAFVVLSSCMARQKYERPAEVLNENLFRTDMLDQDSTTIATVTWREIFTDPLLQQYIQKGLDNNLDIRIALQNIAVADAYLKQSKAAYQPTVSVGPSYTFQTQSLNTQLGQLGGGQRRYLDIFDLSGDISWDADIWGRMKAEERARAAEYFGSVATHQAVKSDLVAAIASAYYQLLTFDEQKRIINETITLRNKNLETTRALKEAGTVTEVAVQQSEALVFNAESLLIDIDTQIELLENAMSYLLAVPSQKIARTTLDQQKMPESYKLGFSANLLANRPDVMAAEYNLISAFELTNAAKAQFYPSLRISGSGGLQSLAIDDLFSANSLFANVVGGLVQPVLNKRQIRTNYEVSLANKERAYLNFRKTLLTAGREVSDALKVYESQDRFIELKRSELTAYRKSVEFSQELVNYGMANYLEVLNASVNSLNAELNISNAEYNKMRAGVELYQSLGGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X336</accession>
    <name>C6X336_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdopterin oxidoreductase</fullName>
            <ecNumber evidence="8">1.2.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807133.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02416"/>
    <dbReference type="EnsemblBacteria" id="ACU08849">
        <property type="protein sequence ID" value="ACU08849"/>
        <property type="gene ID" value="FIC_02416"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02416"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021295_1_0_10"/>
    <dbReference type="OMA" id="WWVGIGH"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="466" mass="53357" checksum="6F362542363670D2" modified="2009-09-22" version="1">MSGHYEAPIREPLIIGHKTYHDITEDIARPIEERAGKLWWVSFWIALVLFIYGFGCIAYTIGTGIGAWGLNRTNNWGWDITNFVWWVGIGHAGTLISAVLLLFRQRWRMSVNRSAEAMTIFAVVQAAIFPVIHMGRVWVGYWVFPLPNQFGSLWTNFNSPLLWDVFAISTYFSVSTVFWFMGLIPDFAMIRDRAKTPWTKRIYTFLAFGWGGKAKHWQRFEELSLVLAGLATPLVFSVHTTVSFDFATSVIKGWHSTIYPPYFVAGAIFSGFAMVQTLLLVARKVAHLEDYITMYHIEIMNIVIIVTGGMVTVAYACEYFIAWYSGSRYEDFVYLSPGAATGPYWWAFWALIICNLVIPALLWFKKIRTNIIATFIIALIINIGMWFERFDIIVINISRDYLPSSWTMFKPSIIDVGVFLGTIGFFGVLFLLYARTFPVIAQAELKTILKISGETYKAKEEEDEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X344</accession>
    <name>C6X344_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted peptidase, family S9</fullName>
            <ecNumber evidence="5">3.4.21.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.83" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02424"/>
    <dbReference type="MEROPS" id="S09.010"/>
    <dbReference type="EnsemblBacteria" id="ACU08857">
        <property type="protein sequence ID" value="ACU08857"/>
        <property type="gene ID" value="FIC_02424"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02424"/>
    <dbReference type="eggNOG" id="COG1770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_0_1_10"/>
    <dbReference type="OMA" id="NMGAGHG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="475"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="695" mass="80928" checksum="DF8DE8D32DE1EAE0" modified="2009-09-22" version="1">MPPKPGRKFNIMNAPTAKKIDKTLEIHGDRRIDPYYWMNERENPEVIKYLEEENAYCDFQMRDTQDFQQQLFDEMKARYKEDDESLPYFFNSYWYISRFEIGKEYPIFSRKFQSLDNDEEILLDVNILAQGLDFLEVGSVAVSPDNKLMSYSSDNMGRRIYSLNFKDLQTGELFEDEIHNTTGKAVWAHDNKHVFYIRKDESLRAFQVYRHLLGADTDEDVLVFDEKDETFDVNVFKTKSLEYVFIASSSTVSDEMRFIPSDNVHADWKIIQPRTEDLEYSVEHYKDEFYIITNADEATNFKIVKTKVAQPEMKYWQDVIPHRPETLLEGFEIFRDFFVLEERTEGLLHIKIIENETGNSHYLQFSDPTYTAYIGLNLEFNTDKLRYGYTSLTKPNSTLEYDMRNHTTEILKEQEVLGGKFFGQNYISERIWAPSRDGIASIPISLVYHKDTQKSAETPLLLYGYGSYGHTVDASFSNVRLSILDRGFVYAIAHIRGGEYLGREWYEEGKMLHKKNTFYDFIDAAKYLISQNYTSEKHLYAMGGSAGGLLMGAVINEEPNMFNGVVAQVPFVDVVTTMLDDTIPLTTGEYDEWGNPNEEEYYHYMKSYSPYDNIETKEYPNILITTGLHDSQVQYWEPAKWTAKLRELKTDDNLLLFKTDMSAGHGGASGRFESLKEDALEYAFLLKLENKTDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X348</accession>
    <name>C6X348_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4296 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807145.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02428"/>
    <dbReference type="EnsemblBacteria" id="ACU08861">
        <property type="protein sequence ID" value="ACU08861"/>
        <property type="gene ID" value="FIC_02428"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02428"/>
    <dbReference type="eggNOG" id="ENOG50330TI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157978_0_0_10"/>
    <dbReference type="OMA" id="MINDQAN"/>
    <dbReference type="OrthoDB" id="1908916at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025381">
        <property type="entry name" value="DUF4296"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14129">
        <property type="entry name" value="DUF4296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4296" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="122" mass="14107" checksum="0522DF485DB1ADE5" modified="2009-09-22" version="1">MKIIRLIILSFLMLSCSELIDRPKNLLPKKQMSELIAEFAQTDQLNNYVPGTNMDNATRYILKQHKIKAADFTESYKYYLASGELDKILSNAQEIILNKDPKAAEFIQKKNKENINVQTVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X354</accession>
    <name>C6X354_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807151.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02434"/>
    <dbReference type="EnsemblBacteria" id="ACU08867">
        <property type="protein sequence ID" value="ACU08867"/>
        <property type="gene ID" value="FIC_02434"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02434"/>
    <dbReference type="eggNOG" id="COG1556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347319_0_0_10"/>
    <dbReference type="OMA" id="NGGKFIY"/>
    <dbReference type="OrthoDB" id="1580190at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="193" mass="21937" checksum="A742B86DCF241F35" modified="2009-09-22" version="1">MSLFKKIVGKLLNQPDQEDGQDLVKLGDQLKNADLDYKFAQLFTHSGGIFNYCADEAEALQILNKILKIEDVKSVFCWDHDLKNFLDVVNVPYTTELELFNDCAFITCEYLIAFDGRIMLSHHNILHYHSSRLPSKIIIMANVSQIVTNLNDAMSKIKRNGNIRNLTSISGSNSKLDTPNKDNTKLFLLLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X372</accession>
    <name>C6X372_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin reductase</fullName>
            <ecNumber evidence="1">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02452"/>
    <dbReference type="EnsemblBacteria" id="ACU08885">
        <property type="protein sequence ID" value="ACU08885"/>
        <property type="gene ID" value="FIC_02452"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02452"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067342_0_0_10"/>
    <dbReference type="OMA" id="KMGQPNR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023856">
        <property type="entry name" value="Bacillithiol_biosynth_YpdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04018">
        <property type="entry name" value="Bthiol_YpdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="322" mass="36439" checksum="1F3B3B44A5694B43" modified="2009-09-22" version="1">MKMEILDLLIIGAGPIGLNCALEAEKNGLNYLIIEKGTIVNSLYNYPLYMRFFSTAEKLEIAEIPFITTAPKPGRQDALEYYQGIARQKELKINLYEKVLKVSKNDIFEIETSKAKYLAKHVIIATGFYDIPNLLNIEGENLPKVKHYYTEPYPYAQQNVVVIGASNSAVDAALETYRKGAAVTMIIKESQISKSVKYWVKPDIENRIAEGSIKAYFNSEVIDIEETNVVFKDEFGKIHEIPNDFVLAMTGYLPDFDFLKNSGIKLKGDKLIPAYNPESMETNVENLYLAGVVCGGKDTHLWFIENSRIHAEIIIRHILNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X386</accession>
    <name>C6X386_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ordered locus">FIC_02466</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807183.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02466"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08899">
        <property type="protein sequence ID" value="ACU08899"/>
        <property type="gene ID" value="FIC_02466"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02466"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_1_10"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="194"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="370" mass="40756" checksum="E275A4AB32A2882C" modified="2009-09-22" version="1">MNRKLKIIMSGGGTGGHIFPAIAIADEIRKRFPDAEFLFIGANGKMEMEKVPQAGYRIIGLNIAGFDRGNLLKNLGLPVKVISSLVKSRQIIKDFKPDFAVGTGGFASGPALFAAAFSGVPIFVQEQNSLPGKTNVFLAKKASAIFTAYPNMEKFFEGVKTLFLGNPIRKNIIEDLIDPETAREKLGLDKHKLTILSVGGSLGSRTLNNAWKENLQKVIDKDYQLIWQTGKTDYLNINSETETRHCRNLQIIEFITNMQLAYSAADVIVSRAGAIAISELAVAQKAVLLVPFPFAAEDHQTKNAETLVEKNAAKMVKDSEMKEQLWNTLTEITENPVLRREMAENLAFFAKPNATEEIVNEIVSSLNSKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-12-15" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B5</accession>
    <name>ACCD_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="1">ACCase subunit beta</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accD</name>
        <name type="ordered locus">FIC_02495</name>
    </gene>
    <organism>
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807212.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6X3B5"/>
    <dbReference type="SMR" id="C6X3B5"/>
    <dbReference type="STRING" id="531844.FIC_02495"/>
    <dbReference type="EnsemblBacteria" id="ACU08928">
        <property type="protein sequence ID" value="ACU08928"/>
        <property type="gene ID" value="FIC_02495"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02495"/>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_1_1_10"/>
    <dbReference type="OMA" id="PEGLWIK"/>
    <dbReference type="OrthoDB" id="504557at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000389742" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01136"/>
        </source>
    </evidence>
    <sequence length="282" mass="31563" checksum="E905D94090E07CE7" modified="2009-09-22" version="1">MAFDWFKRKTKNITTSTEDKKDVPKGLWHQTPTGKIIEHEELKANNYVSPEDGFHVRIGSREFFSILFDDNKFTELDANVESVDMLGFKDTKAYVDRLKEVKAKTKLTDSIRNAVGRVNGEQMVISCMDFAFIGGSLGSVMGEKIRRAVDYCIANRLPYMIICQSGGARMQEATYSLMQLAKVQAKLAQLSEEGLLYIAYLCDPTFGGITASFAMTADIIMAEPGALIGFAGPRVIRETIGKDLPEGFQTSEFLQEKGFVDFIVKRTEIKEKVSKTVKLLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C6</accession>
    <name>C6X3C6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807223.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02509"/>
    <dbReference type="EnsemblBacteria" id="ACU08939">
        <property type="protein sequence ID" value="ACU08939"/>
        <property type="gene ID" value="FIC_02509"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02509"/>
    <dbReference type="eggNOG" id="ENOG502Z7J9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019163_0_0_10"/>
    <dbReference type="OMA" id="GQYLIFE"/>
    <dbReference type="OrthoDB" id="930343at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021246">
        <property type="entry name" value="DUF2797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10977">
        <property type="entry name" value="DUF2797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="30407" checksum="0D6CCC2E3C27C78E" modified="2009-09-22" version="1">MKFTGQVLKMATQNGKPIQYYLNLSHDLINLNQVIGRTIKIKHIGYECVNCGTDEKVFRMGFCKRCFFESPYASDTIIRPELSKAHLGIGERDLEVEQSIQLAPHIVYLAYTGEVKVGVTRESQLPTRWIDQGATFALPIAKTDNRYEAGMIEVALKEHIADKTNWKKMLEDDFEDDLDLADFRNRIKQHFPENFQNFYTMEHEMLRLDYPYEAPEKIASCTLDKNPEIEGVLTGIKGQYLCLGSGNFINVRAHEGYVIELTLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F7</accession>
    <name>C6X3F7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807254.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02540"/>
    <dbReference type="EnsemblBacteria" id="ACU08970">
        <property type="protein sequence ID" value="ACU08970"/>
        <property type="gene ID" value="FIC_02540"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02540"/>
    <dbReference type="eggNOG" id="ENOG50333M9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1575707_0_0_10"/>
    <dbReference type="OrthoDB" id="1400067at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="20150" checksum="ADAE044435D19C6B" modified="2009-09-22" version="1">MKKSLFILITVLFGSESFAQELKYDWKTMKPEQRKELIQQMNPQQRMKLLNEFRENMMVSELEVPQTDQTEFKKLYAEYQDRQNAIKSKFKAAEDYENMSDAEARRQVEESFVIGQQLLNNRKAYAEKFMKVIKPQQVLQMFQTEGKMRNKILDKKDGQPKQGPQSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G2</accession>
    <name>C6X3G2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807259.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02545"/>
    <dbReference type="EnsemblBacteria" id="ACU08975">
        <property type="protein sequence ID" value="ACU08975"/>
        <property type="gene ID" value="FIC_02545"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02545"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_0_10"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="20527" checksum="4D0F06DA39250E70" modified="2009-09-22" version="1">MKILLASGSPRRKELLQSLGFTFEVVSADCDEIYPEGLSVDKIAAYLSELKSNAFRKLAPGEVVITADTIVAVGTEVLGKPKDHAEAKAMLRRLSSKTHQVYTGITVRNNEETVTATDVADVEIDDISDEEIDFYIKNYKPFDKAGSYGVQEWLGMAKIRKINGSFYTVMGLPTHLLYAILKDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G5</accession>
    <name>C6X3G5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosyl pyrophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02548"/>
    <dbReference type="EnsemblBacteria" id="ACU08978">
        <property type="protein sequence ID" value="ACU08978"/>
        <property type="gene ID" value="FIC_02548"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02548"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_0_10"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="8">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="320" mass="35110" checksum="19299302CA04D2D2" modified="2009-09-22" version="1">MHIQKKLKMAEQPSYLFSTRTSKVLAEKIAQHYGQEMGKINFQEFSDGEFEPVLDQSVRGGRVFLIGSTFPPADNLLELLLMIDAAKRASAKSITVVLPYYGLARQDRKDQPRAPIGAKLVANLLTAAGATRVMTMDLHADQIQGFFEIPVDHLYASTLFIDHIVSLNLENLTIASPDMGGAKRAKNYAGHLSAEVVICYKERKKANVIEEMFLIGDVEGKNVILIDDMIDTAGTLCKAADILVANGAKSVRAMASHGVLSGKAYENIENSQLSEVIVTDSIPIKTHLSSKIKVLSCAELFADVMKMVHENKSISDKFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J3</accession>
    <name>C6X3J3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="12" type="ordered locus">FIC_02576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807290.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02576"/>
    <dbReference type="EnsemblBacteria" id="ACU09006">
        <property type="protein sequence ID" value="ACU09006"/>
        <property type="gene ID" value="FIC_02576"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02576"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_3_0_10"/>
    <dbReference type="OMA" id="ENTVNHK"/>
    <dbReference type="OrthoDB" id="1279539at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU09006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="196" mass="21913" checksum="1CF5333462A3CDEE" modified="2009-09-22" version="1">MFLENTINHAKQSGWMEVICGSMFSGKTEELIRRLRRAEMAGQNVEIFKPKLDTRYAEEEVVSHNQNKIRSTPVESPNEILLLGSTCDVVGIDEAQFFDESIVEVANKLANSGIRVVIAGLDMDFMGRPFGPIPNLMATAEYVTKVHAICRRTGNLANHSMRITAGNDLVQLGETESYEAVSRKVFNEEFLNTQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K2</accession>
    <name>C6X3K2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coagulation factor 5/8 type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00532"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06990">
        <property type="protein sequence ID" value="ACU06990"/>
        <property type="gene ID" value="FIC_00532"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00532"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023506_0_0_10"/>
    <dbReference type="OMA" id="GWMLLNY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="364"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="612" mass="70786" checksum="3EEBAF9F96A0B7AF" modified="2009-09-22" version="1">MYGFFLNITLSVLSFCLNFTFPQSKIMNARTLFTLVFSLVITWVSAQQKTYCNPINIDYGYTPFEVFSKQGKHRATADPVIVNFQKKLFLFSTNQEGYWHSDDMLNWKFVKRKFLRDNKYIHDLNAPAAWAMKDTLYVYGSTWESDFPIWKSTNPTKDEWEIAVDTLKVGAWDPAFHYDEDTNKLFLYWGSSNEWPLLGTEVKMNTLQSEGYVKPILRLKPEDHGWERFGEYNDNVFLQPFVEGAWVTKHNGKYYMQYGAPATEFSGYADGVYVSKNPLEGYEYQQHNPFSYKPGGFARGAGHGATFQDNYKNYWHVSTIFISTKNNFERRLGIWPAGFDKDDVMYSNTAYGDYPTLIPEFAQGKDFTKGLFTGWMLLNYNKPVQVSSTLGGYHSNYAVDEDIKTYWSAKTGNSGEWFQTDLGEGSTINAIQVNYADQDVEFMGKTTGTMHQYKIYISNDGKNWKVLIDKSQNTTDVPHDYIELEKPAKARYLKMENLKMPTGKFALSGFRVFGKGGGEKPEKVQNFVPLRADPKKYGERRSIWMKWQQNEKADGYVIYFGKTPDKLYGSIMVYGQNEYFFTGADRTDAYYFQIEAFNNNGISERSEIFKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L5</accession>
    <name>C6X3L5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00545"/>
    <dbReference type="CAZy" id="GH97">
        <property type="family name" value="Glycoside Hydrolase Family 97"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07003">
        <property type="protein sequence ID" value="ACU07003"/>
        <property type="gene ID" value="FIC_00545"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00545"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011166_2_0_10"/>
    <dbReference type="OMA" id="VNSHEAV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029483">
        <property type="entry name" value="GH97_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019563">
        <property type="entry name" value="GH97_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029486">
        <property type="entry name" value="GH97_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14509">
        <property type="entry name" value="GH97_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14508">
        <property type="entry name" value="GH97_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10566">
        <property type="entry name" value="Glyco_hydro_97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973665" evidence="2">
        <location>
            <begin position="28"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="GH97_N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_97" evidence="3">
        <location>
            <begin position="317"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="GH97_C" evidence="5">
        <location>
            <begin position="621"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="725" mass="83033" checksum="17962A138F93A1CE" modified="2009-09-22" version="1">MIRKRSFMKNIKISALFLLMGSFALNAQSLKSPDGKFEMVFQLKEGVPFYNLKYAGKTVVEDSRLGLKLLRDGDIQFASEIENKDQKGKNLDNGFTKTAEKFDTKKESWDPIMGEKKSYINHYNELAVTLNQDANDRHIIVKFRLFNEGLGFRYEFPEQKNLNYFIIKEEDSEIDLPTDMKAWWLAGDYDSQEYQTQTTNLSEIPARWPTSYDGNASQTLIKNGVQTPLMLKKEGKDQLYVNISEAAVINYPASNLELDAANFKFKTHLTPDAQGAKGYIQTPAVSPWRTIIVSPKAEEVLASKMIFNLNEPTQYKDTSYIKPTKYMGVWWEMIIGKSNWSYSTANNVHIGKTDFSKLTPNGKHAANNTKVKEYIDFASANGFDALLIEGWNTGWEDWFGHSKEFVFDFITPYPDFDIKMLNEYAHSKGMKLMMHHETSGSATNYERWADKAFQLMNKYDYPAVKTGYVGNIIPRGEHHYSQWTINHYLRIAEKANEYKIMVNSHESVRPTGLSRTYPNWIAAEAARGTEFEAFGGNNPDHQTILPFTRFMGGPMDYTPGIFQTKLDYYFPGDTRFVKTTLAKQLALYVVMYSPLQMAADLPENYARHMDAFQFIKDVALDWDDTVILSAEPGDYIHTARKTKGKDEWFVGGITDENSRNYTVDFSFLPKGKKYEATVYADGDNADYINNPQSYKIYKKTVTNKSKMPMKLVRSGGYAISVQPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q5</accession>
    <name>C6X3Q5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgA</name>
        <name evidence="10" type="ordered locus">FIC_00588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782190.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00588"/>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07043">
        <property type="protein sequence ID" value="ACU07043"/>
        <property type="gene ID" value="FIC_00588"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00588"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_5_10"/>
    <dbReference type="OMA" id="TWCPWYM"/>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="281"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="468" mass="53053" checksum="8B638CA8A7A10494" modified="2009-09-22" version="1">MKIFNISLECYPVAKVGGLADVVGALPKYLNKIDGVESSVVMPWYNKPFMHQHEFEVVFEGLIHQSYHTFPVKVMKEKSGVLGFDLYCVKIPGLLDRDNPYGYWDESQQFLAFQHGVLHWLTSMKIRPDILHCHDYHTGLVPFMIENCPEFSFLKGVKTVGTIHNGEYQGQMKWEMASYLPWYNSDHWGLLDWDGYINPLACMIKCCHRFNAVSEGYLQELFHSFRGLESLMQQEHAKAFGIINGIDTEVWDPATDIFLDFRFNTESAAAGKWENKKSLCEEYGLNPDLPLFGFIGRFAGEKGADLLPEIVSESIQQTHGALNIIILGSGDKHIEHQLGELNKTFSNFALELGYREPLSHKIYAGTDFLLMPSRVEPCGLNQMYAMRYGTVPIVRYTGGLRDTVADISTGGNGLNFGTATAEDTVHAMHRALHIYHDRGLMKSLIRSNMANDFSWENSAGKYMHIYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R0</accession>
    <name>C6X3R0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00593"/>
    <dbReference type="EnsemblBacteria" id="ACU07048">
        <property type="protein sequence ID" value="ACU07048"/>
        <property type="gene ID" value="FIC_00593"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00593"/>
    <dbReference type="eggNOG" id="ENOG5033GBW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195187_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="81" mass="9181" checksum="4178EF22F8BE892F" modified="2009-09-22" version="1">MNLDEIIMSTADLKLDLISKITALNDAAIIRTLQKTLDFELDKDVLLLNDAQKERISKAHNDEVISDEQGNTDLAQWLQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S1</accession>
    <name>C6X3S1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782206.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00604"/>
    <dbReference type="EnsemblBacteria" id="ACU07059">
        <property type="protein sequence ID" value="ACU07059"/>
        <property type="gene ID" value="FIC_00604"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00604"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_10"/>
    <dbReference type="OMA" id="VIAKYWG"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="558" mass="60250" checksum="2C6F3709B65EB8E9" modified="2009-09-22" version="1">MSNLWRTKPLNQLLAEADETEHGLKKTLSSTSLIALGIGAIIGAGLFSITGMAAANYAGPGIMISFIIAALGCAFAGLCYAEFASMIPVAGSAYTYSYATMGEFIAWIIGWDLVLEYAVGAATVASSWSGYLGRFFYSFGVALPEQLMTTPFDITSTGASGLINLPAIFIVLIMSLVLIKGTSESAWVNSAIVILKVGIVLLFIIVGFKYVKPENLTPLIPENTGKFGEYGWTGIIRAAAVVFFAYIGFDAVSTAAQETKNPKKSMPIGIMGSLLICTVLYIIFAYVMVGVVHYKDFTAGGGSDHLAPVAIAIDAMGEVVNGTMVPAYPWLNTTIILAILLGYASVILVMLMGQSRVFYAMSKDGLLPKVFSEIHPKYRTPYKSNLFFLVFVSLFAAFIPGRVVGEMTSIGTLFAFILVCVGVLVLRKTQPNAPRAFRTPLVPLIPVLGILVCFGMMAFLPLDTWIRLVCWMMIGLDLYLYSGIKNSHLGKLNNTTNDPKNFTITAISGAVLTAILAVLAFLHHQNAETDDSGLIIFSVVMAVIHAVLYGYYFFKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T7</accession>
    <name>C6X3T7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00620"/>
    <dbReference type="EnsemblBacteria" id="ACU07075">
        <property type="protein sequence ID" value="ACU07075"/>
        <property type="gene ID" value="FIC_00620"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00620"/>
    <dbReference type="eggNOG" id="ENOG5032R9W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1110138_0_0_10"/>
    <dbReference type="OMA" id="NREWELA"/>
    <dbReference type="OrthoDB" id="1946051at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="29479" checksum="FCB7B57F845A956C" modified="2009-09-22" version="1">MCSETRPNAKPENVSGNSKRQTVKLFNFIKRQSKTDFSPEQTIRRLVDYMPDFYKTQRQFINCVEFLENREWELALDSLIELADETEHYFSEDFWLGLADSADKMNLTDKANYCRKQIKRNVEDIKSKTPFGWTTIKFDDTHFQHHISEKLKEEWATERREKDKVQELLTKEGVHLKSHGRSGFLYITENGKIAEVEFELGMNGLILYFNSLTNWSLPTKQTLTADEKQKIKIDINNWSTKTKNAIEFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W5</accession>
    <name>C6X3W5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00648"/>
    <dbReference type="EnsemblBacteria" id="ACU07103">
        <property type="protein sequence ID" value="ACU07103"/>
        <property type="gene ID" value="FIC_00648"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00648"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013583_0_0_10"/>
    <dbReference type="OMA" id="YFELYFP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973672" evidence="1">
        <location>
            <begin position="25"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="944" mass="109775" checksum="91732F53A1DC5898" modified="2009-09-22" version="1">MSVTKMKRFLWGLMLITNFVAVDAQQDSIYINAKFSPNQRQVTVNQEIIYTNKTASLLQNIKLLNWIAAYKSQSTPLVYRKLEDRKTEMHFAKAGELGSTSDLEIKIGDSSVQRPDLTKENLFIPLSKPLKQGEKITISLQYKLNLPLQKFTGYGSDGKSWQLKYFFIVPDGFETDTPNERYFIDIEEKQSAANYWKVHLDLPAQYYSYSNLPEIQPNSFEGKLNDDPEFLITESRFPSIETEIDGQKISVGFGYQINEDEKTNLEFYLPQHLRFIKDRIGFLPAKIFISQKFRQDENFTGIDDIKFWKFRYKLFSDLEQADLNYFSVLSKNIVEQSSIFNKSEDHWIINGVKTYLEIQYIDQYYKERKLLGDLPENAKIFGMKPLKFFHASKIKLSERYGLAYQYILTQNLDQAIDIPFENLSNFNAMTISHFETGSLLSFIAEKMGKENFDAFLRDFFSKNAHSKPDSKAFTDALSVASGYSADFLEPFIQHKNRVNFKLKRFSKKDDEFEVKISKNTPLPIPFKIETASDDGTTHAFWFDTDDSRKNTSYRIPQSDATKIVVNSEYIFPETNFRDNYLYTKGLFANTKKIRLKFFKDIPNPEYNEIYLNPRVTFNAYDKVLVGLNFKNTSFFQRKFNYSVTPYFSSGTGKLTGSGAVGYTFQPAESFYRSLDFAVSASHFHYDYDLTYRKISAGAAINFSKDPRSDIGRSLAFSYNYFEKDLNPAMIARKEYAKYNLWNIGYGYSDRRVIHEKYFGANLQWMEDFQKISAEASYRWEFADDQKINFRFFGGYFISNSTQNNLFDYGISRVSNYSFSYGLLGQSATSGLLAQQFILAEGGFKSYVGRSANQWIGAVNVDSHVWRWFNVYADAGMYKNKYRSPEFIWDSGVKVKVIPDFLEVYFPVQSSLGFEPSFKDYAQRIRFTLVLNFGAVTDYFRRGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X1</accession>
    <name>C6X3X1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">FIC_00654</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00654"/>
    <dbReference type="EnsemblBacteria" id="ACU07109">
        <property type="protein sequence ID" value="ACU07109"/>
        <property type="gene ID" value="FIC_00654"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00654"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_10"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="638"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="670"/>
            <end position="677"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU07109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="970" mass="108162" checksum="074E8CE29992F11E" modified="2009-09-22" version="1">MSIAVDDATKFRIFADSQNPNFEEVLKMKDSKEYIEIYGAREHNLKNISVKIPRNELVVITGLSGSGKSSLAFDTIFAEGQRRYIETFSAYARQFLGGLERPDVDKIDGLSPVIAIEQKTTNKNPRSTVGTVTELYDYLRLLFARVSDAYSLNSGKKLVSYTEEQILDAIKTNYTGEKLLLLAPVVTSRKGHYHELFVQMAKKGYSQARIDGELQDIEYDLKLDRYKTHDIDIVIDRWIIGENASEGRMEKSLRTAMQMGEGTIGIQKLGSTDIEYFSKNLMDAESGHSLALPEPNTFSFNSPKGSCPHCKGLGIVQKVNTGYFVANPKLSVNQGGLLPLEDMKSNKWILGQIKNILEIFGLNLSTPFKDIPEEAIDYIYNGCHREFSKDLKYAGISKKIKVNFDGLVNIINEMIGDKESYDAILLERHFTTEETCAECGGTRLQPSSLSFKIDGKNIAQISALSLLDLMEWLNDIEDKFSTKNQIIAHEILKEIKTRLQFLLDVGLDYLSLSRSSRTLSGGESQRIRLATQIGSQLVNVLYILDEPSIGLHQRDNERLIKSLKNLRDIGNSVIVVEHDKDMILEADEVLDIGPRAGKFGGEILWQGKPEDLLKADTVTADYMTGRRKIEVPTERRAGNGKSLVLKGASGNNLKNVNIEIPLGKLVVVTGISGSGKSSLISGTLYPILNRHFYRALQEPLPYKKFEGIENIDKIVDVDQAPIGRTPRSNPATYTGMFTDIRNLFAELPESKIRAYKAGRFSFNVKGGRCETCQGGGLKVIEMNFLPDVYVHCETCHGKRFNRETLEVRYKGKSISDVLEMTIDEATEFFKPLPKIFAKVKTLQDVGLGYITLGQQSTTLSGGEAQRIKLATELAKRQTGNTLYILDEPTTGLHFEDVKVLMEAISKLVDLGNSFIIIEHNLDVIKLADHIIDVGMEGGNKGGEIVAKGTPEEVAKSRKSLTARFLKKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X411</accession>
    <name>C6X411_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="3">2.7.8.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00694"/>
    <dbReference type="EnsemblBacteria" id="ACU07149">
        <property type="protein sequence ID" value="ACU07149"/>
        <property type="gene ID" value="FIC_00694"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00694"/>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_3_0_10"/>
    <dbReference type="OMA" id="IFFDFFD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="244" mass="27248" checksum="D09F9ED68C1E9971" modified="2009-09-22" version="1">MLPNALTMNFIKNNLANAFTLANLFSGSIGVIHLITGDYQVTAICIILSLILDFFDGFIARAMKSNSNLGVQLDSLADMVSFGVLPGITVYKALEPLGNQLFGVEIPFEIKYLGLFITLFSCLRLAIFNLDDEQTYYFKGLNTPSNTILIFGLYYAFMETGAFGFLFENPLLLLLLTAFSSWLLISPIRMISLKFKSMKLKDNYPKVALLIGAILILVIFKTVGIPLAILYYVFISLIFQKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X440</accession>
    <name>C6X440_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782324.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00723"/>
    <dbReference type="EnsemblBacteria" id="ACU07178">
        <property type="protein sequence ID" value="ACU07178"/>
        <property type="gene ID" value="FIC_00723"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00723"/>
    <dbReference type="eggNOG" id="ENOG5033XG1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044890_0_0_10"/>
    <dbReference type="OMA" id="NGQAINT"/>
    <dbReference type="OrthoDB" id="1343318at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970642" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="266" mass="28441" checksum="6BE618005A5B6F8B" modified="2009-09-22" version="1">MKKIFTILGLVSATTIMFAQTNLVQNPGFESDLTSWAAGTGSGYTAPAILTTNPHSGLKLAAYELPAATTGFYQNVAIAGNTQYTLTFWYKASTTRPEGTTQNNIFRLWSVMKDTTGTPVYNSATANDDPLRSNNGYLPIAPTAWTQHTVVFTSHPSAASIDVAFRSYGSGSSYVDDVQLVQGLLAVTDVSAFDKSVKMNTVVGNELRLILPGKATVNIYSADGRLVSSNRVDNGQAINTSSMTKGNYIVTVDNGSAKVSRKVIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A5</accession>
    <name>C6X4A5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00790"/>
    <dbReference type="EnsemblBacteria" id="ACU07243">
        <property type="protein sequence ID" value="ACU07243"/>
        <property type="gene ID" value="FIC_00790"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00790"/>
    <dbReference type="HOGENOM" id="CLU_3328169_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="38" mass="4690" checksum="23C19D599FB1C5AC" modified="2009-09-22" version="1">MQLFWLHFFGKDSLKGLKIRLIIKQNAKKNIRRKAWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F4</accession>
    <name>C6X4F4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782438.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00839"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07292">
        <property type="protein sequence ID" value="ACU07292"/>
        <property type="gene ID" value="FIC_00839"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00839"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_6_10"/>
    <dbReference type="OMA" id="VKFLDYV"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="193"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="367" mass="41827" checksum="A39FDC7CFBF92BD4" modified="2009-09-22" version="1">MKIAFDGKRFFQNKSGLGNYSRDLVRILATGFPENDYLIFNKTETSNGAAILQLPNVNFVPTTKGYLTRQLKMGIDAQNAGAEIFHGLSGELPLKWNSKPIKKIVTIHDLIFLRYPKYYPFIERKIHLWKFRKAARQADLIIAISEQTKRDIVEFLHVPEDKIQVVYQGCHQAFKENQGEQVLNSVKAKYGLPDRFILNVGTIEERKNLLNIVKAVNGTEIPLVVIGRKTKYFNKIRKFLKKNKLENQVHFLENVSMDELAAIYKLADIFVYPSLFEGFGIPVIEALFSGTPVITSNVSCLPEAGGENSVFIDPNNFKDISAKINFLLNNRSERDRRAEKGLQFVQKFSDDTISKQLMSLYKGVLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4G7</accession>
    <name>C6X4G7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07305">
        <property type="protein sequence ID" value="ACU07305"/>
        <property type="gene ID" value="FIC_00852"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00852"/>
    <dbReference type="eggNOG" id="ENOG502ZB8K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065522_1_1_10"/>
    <dbReference type="OMA" id="QYFGVLT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018874">
        <property type="entry name" value="Phage_Mx8_p63_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10546">
        <property type="entry name" value="P63C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P63C" evidence="1">
        <location>
            <begin position="161"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="294" mass="34246" checksum="1106F46F23C63E04" modified="2009-09-22" version="1">MEIHHASHRGYLKIGTEEIGIVEIPCAVLENKKRIISQTGLFAAFNRPRKGEKRQEGLPSIIGAKNLVEFVNDDVLERIQPIHYYHSNGLTAVGYDAELIPLVCELYLDAEEKGVIISSQEKIVKQAKIIIRSLAKVGINALIDEATGYQYDREKDELQKLLSKYIQEDYLKWQSRFPRKFYQEAFRLFHWKYDPFSLKRPGYLGKFTNEFVYNELPKGALEKLRDLNPKNGKGNRSRRHHQHLTEEIGIPHLDKHLMRLITVMELSDNMTDFKTKFGKVFNKPIQTQIDFEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H0</accession>
    <name>C6X4H0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00855"/>
    <dbReference type="EnsemblBacteria" id="ACU07308">
        <property type="protein sequence ID" value="ACU07308"/>
        <property type="gene ID" value="FIC_00855"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00855"/>
    <dbReference type="eggNOG" id="COG3861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545342_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="173" mass="19717" checksum="6EA80A1997CF610B" modified="2009-09-22" version="1">MSYTVVGMFPTNEAADKASSKLDSAGFGKEDYQISRYTTTGEYTEGSEYDEDEKTTGFWNWLFGDDDHEKKKYSYAGTKSNIITVYTNTSDRAEKARDIMNDNGAINVNDFSRDRYMGEEFASPDNNLTADERARIITKARNDLYLTSENRSYNFRTRGMSNEMDSAGNEDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4J4</accession>
    <name>C6X4J4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argC</name>
        <name evidence="7" type="ordered locus">FIC_00879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782478.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00879"/>
    <dbReference type="EnsemblBacteria" id="ACU07332">
        <property type="protein sequence ID" value="ACU07332"/>
        <property type="gene ID" value="FIC_00879"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00879"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_10"/>
    <dbReference type="OMA" id="FSWRNNN"/>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="324" mass="36296" checksum="376E95B6A7C6E966" modified="2009-09-22" version="1">MEKIKAGIVGGTGFTAGELIRILLYHPDVEVSFVTSQSLQGYLITDVHKDLFGETNLKFENLAQPADIIFLCLPHGESKNWLIENEKRIAPDTKIIDLGNDFRVDEEWNEKKFIYGLSEFNKEKIAKALYIANPGCFATAIQLGILPLLKKENIEKIHCVGITGSTGAGKALHQTLNFNWRSDNISPYKTFTHQHIAEIEKSISLISATKTEINFVPWRGDFTRGIFVTLMMESDLTQIEIVEIYRYAYKYSKFVFVSASPIDLKQVVNTNKAAIYIEKAGKNLAVHVAIDNLLKGASGQAIQNMNLMFGFNEKAGLNLKPSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M1</accession>
    <name>C6X4M1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00907"/>
    <dbReference type="EnsemblBacteria" id="ACU07359">
        <property type="protein sequence ID" value="ACU07359"/>
        <property type="gene ID" value="FIC_00907"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00907"/>
    <dbReference type="eggNOG" id="ENOG5032WBR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146657_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="139" mass="16226" checksum="2A3B6EC0455BCA21" modified="2009-09-22" version="1">MITLLIFFGLTDFYCQNSVLKDIDATKVLSRNVTQNFKDNKIEEAFNVLSPHWPMPVNEINNLKTQSILTINLISERYGKAESIVKVSEQNIMDVGFRETYLVKFEHTAIRLIFTYYKNSKGWLVNGFVWDSEFDEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R3</accession>
    <name>C6X4R3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiol:disulfide interchange protein tlpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782547.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00950"/>
    <dbReference type="EnsemblBacteria" id="ACU07401">
        <property type="protein sequence ID" value="ACU07401"/>
        <property type="gene ID" value="FIC_00950"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00950"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_1_10"/>
    <dbReference type="OMA" id="KVINFWA"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="21095" checksum="CE2F1DF4C7016CBB" modified="2009-09-22" version="1">MKNILVGLMVLAAFTSCKKETTAAENSTVNEVDSVSDPVISESASPFRQIELSPDQTSQILAKKDNDTLYVTNFFATWCGPCMREIPHFKDKMQELKYQPVKFTFIGLDAKEDWPTKVKAFAEENNLSQNIVLVDGEKLTPAFFPANFKQWDGGSIPFTFMRKGDKTDETIGMMSKELLDEKINSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S4</accession>
    <name>C6X4S4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782558.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00961"/>
    <dbReference type="EnsemblBacteria" id="ACU07412">
        <property type="protein sequence ID" value="ACU07412"/>
        <property type="gene ID" value="FIC_00961"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00961"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_10"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="315" mass="33330" checksum="50E22B1464A3BDCB" modified="2009-09-22" version="1">MAVFVYAENINGVYKKAAFEAVSYAKAVAEKTGETVTAISVNPTDSSDLLYKYGAEKVINIKDEGLKNFSAKAYAQAVSEVADGNVLVFPHTTDASSVAPMLAIMKNYSLITNVLEAPESISPFQVKRRAFSGKGFMHAKADTQGVIVTVSQNAFGVKENTVSGTEEVKNLTVTNEDTKVLSHEQSSGKLDLKEAEIVVSAGRGMKGPENWGMIEELANVLGAATACSKPVSDIGWRPHSEHVGQTGKAIAPNLYIAVGISGAIQHLAGVNSSKTIVVINSDAEAPFYKSADYGVVGDAFQIIPELTAKIKALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U7</accession>
    <name>C6X4U7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00984"/>
    <dbReference type="EnsemblBacteria" id="ACU07435">
        <property type="protein sequence ID" value="ACU07435"/>
        <property type="gene ID" value="FIC_00984"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00984"/>
    <dbReference type="HOGENOM" id="CLU_3080111_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="52" mass="5966" checksum="51A2EF0E1E655609" modified="2009-09-22" version="1">MPFQNKEIFAKMPISGQLQPSGALLAAFSFLKFFAAFFFVAKHFFRRKVYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X1</accession>
    <name>C6X4X1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sensor histidine kinase</fullName>
            <ecNumber evidence="9">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01009"/>
    <dbReference type="EnsemblBacteria" id="ACU07459">
        <property type="protein sequence ID" value="ACU07459"/>
        <property type="gene ID" value="FIC_01009"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01009"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_22_1_10"/>
    <dbReference type="OMA" id="LEVWDRG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="665"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="885" mass="100115" checksum="E0FEE0E89802CA81" modified="2009-09-22" version="1">MMSSPLLFLLVILYLGTLFFVAFWAEKKKSNFWVNNPYVYSLSLAVYCSAWTYYGSIGVASNQGLEYLAVYIGPVIIIPAWIYINSKIIRISRVNKISSIADFISLRYGNRRFLGALVAGVCILAVIPYIGLQIKAISETFHLMTGSENSDNILLDNATYVVLIIAIFSAYYGTKYVDASEKRLGIISAVAFESFLKLVFFLALGVFVTYGVFNGFDDIYEQASKLPDFKQKNTLNGLEGGFNWFLMSLLSMSAIFLLPRQFHTTIVENRTEKHLKTAIWLFPLYLLLLNLFVFPIAWGGKILFLGENVNPEFYSILIPQKFGNTLIAAMVFFGGLSACISMIIISSISLSVMLSNNIIIPYGWLNSLKSETENSNNRTIVNIRKASIFSLIILGFMYMRYLISSSTLFSVGLIAFVLIAQLAPSFFGAVFWRRGSFAGAVTGIIAGILISYAYLIVPNYFEFGYQNSAFFNFFKLDYLSPVANVFFWSLLINGGLFMIISSCVAENYRARNFAELYVDINDYIQHHENAYIWKGTANISDIRRILARFLGEKKTKQALKIFNLKYNISDENDSADARFIKFSENLLSGRIGTASAKILIDGVTKEDKITLPEVLRILEESKDNISMNKQLTEHSHQLRKMSEKLQDANETLLIKDRQKDDFLDSVAHELRTPITAIRATSELLMDDEDMPTEIKKDFLENIISESDRLAEIINDILYLDKLEAGTTPLNLEHGNIVNSYHKALKPLLQLFEQKHLHHSEVNLLQEETFVYDEMKMIQVFQNILGNALKFAGDQGMIQVKFQEKDGRLKVSIFNTGKTIPDEDLEFIFEKFYQSKHQNLRKPVGSGLGLAICKRILNAHGGDIAAVNKEIGVTFELTLPNRNEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X566</accession>
    <name>C6X566_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07554">
        <property type="protein sequence ID" value="ACU07554"/>
        <property type="gene ID" value="FIC_01104"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01104"/>
    <dbReference type="HOGENOM" id="CLU_3365104_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="4255" checksum="861277121FDE91F4" modified="2009-09-22" version="1">MMKKEPKKSRLGFNFSFALMQKKQKIKTWILLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X577</accession>
    <name>C6X577_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neopullulanase</fullName>
            <ecNumber evidence="3">3.2.1.135</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.135" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805850.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01115"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07565">
        <property type="protein sequence ID" value="ACU07565"/>
        <property type="gene ID" value="FIC_01115"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01115"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_3_10"/>
    <dbReference type="OMA" id="YRSDYIE"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031216">
        <property type="term" value="F:neopullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015171">
        <property type="entry name" value="Cyc-maltodext_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019492">
        <property type="entry name" value="Cyclo-malto-dextrinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10438">
        <property type="entry name" value="Cyc-maltodext_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09087">
        <property type="entry name" value="Cyc-maltodext_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973608" evidence="1">
        <location>
            <begin position="20"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="128"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="618" mass="71684" checksum="F92FD4B7A7718743" modified="2009-09-22" version="1">MKKLLPVFLLFLSFNSLFSQRIERIEPANWWTGMKYNTVTLLIYGKDLSDLQPAVSYPGVTITESKTVENKNYLFLTLQISADAKPGTVKIKFSKDKKILLTKDFPIFAREANSANRESYGSKDAVLLIMPDRFSNGDEKNDIVKTTLEQKLDRTHENARHGGDIQGIINHLDYIQSLGYTQIWNTPLIENDEPAYSYHGYAATDFYRIDPRFGSNEDFKKLSAEARKRDIGLIWDVVLNHCGTQYYFIKDLPEKSWVNYPDPENRLRTTHLKTTVTDLYATEIDKEEYLSGWFDGHMADLNQKNPLVAKYLTQNVIWWIEYAGISGLRVDTYSYSDKNFLAGWSKTVLEEYPRINIVAEEMSRNIAQTSYWQIDKDNKDGYKSYIPMMMDFSLNDQIVSALNEKSNWFSSWRKVYESVANDFLFPHPDNQLIFPDNHDVDRFYSRINKNFDHWKLGIAMYMTMRGTPQFFYGTEVLMTNDKAGSDGQRRSDFYGGWKGDTKSAVTETGLSDEEKEAKKYFAHLLNWRKTSDAVAHGKFKHYGPTDNDVYVYFRYTDTQKLMVILNKNPEQVTLALDRYNEMIPLKFQAKEVISGRKVSYQNTVEIPAGTAMILEIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5A8</accession>
    <name>C6X5A8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805881.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01146"/>
    <dbReference type="EnsemblBacteria" id="ACU07596">
        <property type="protein sequence ID" value="ACU07596"/>
        <property type="gene ID" value="FIC_01146"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01146"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_4_10"/>
    <dbReference type="OMA" id="EMAEAQH"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973479" evidence="3">
        <location>
            <begin position="22"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="436" mass="49225" checksum="3A4FB27A8FF60CEF" modified="2009-09-22" version="1">MKLKTRTTLLLLSLFFFQVNAQTTERTLMLNEVVQMALENHTQLKLSSQNILIARQQTKTAELQKLPNITASANAFYLGDALILDKDLSKIATVGMPHFGNTYSLQASELIYKGGLVKKSIEVSELREQLAELDLEKDEQNIKFLVMSNYLDIQKIINQKNVFLNNRKLATERLENVKKFYKQGMVTRNEIIRGELLLKNLEQGILTLDNNRAALNYQLATAVGLSPDILIVPTASFSEAAADTGLGYYLDRAHQNHPVLKYAQTGIEMANKNIEIINTDKKPTIAAFGGYDMARPVTSSLPAQDFYTNTWQAGLSISYNIDNLYKTKEKEQIGKLQLSQARNALALQQENLDVQTNAAYLKWQEAIQQARLSKESEDLASENYRIIEAKYLNQLALQADMIDASNAKLEAELQYANSEINVQYQYYNLMKTTGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B6</accession>
    <name>C6X5B6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805889.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01154"/>
    <dbReference type="EnsemblBacteria" id="ACU07604">
        <property type="protein sequence ID" value="ACU07604"/>
        <property type="gene ID" value="FIC_01154"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01154"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079636_1_2_10"/>
    <dbReference type="OMA" id="ERYAKGG"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4142" evidence="1">
        <location>
            <begin position="63"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="203" mass="21714" checksum="015EB0D4E8B1C169" modified="2009-09-22" version="1">MKNSVLVLMCAATLMACKKNETTSTESNTDSSMMTVPADSVMAVDSTTMSGMGDNQTGNLSEQDKMFANEAAKGGMTEAMLGQLGADNGTNAKVKSHGQMMVSDHTKANQELKSWAASAGYSLPATPDAAQQKIAEDLRAKKGAEFDRAYTDIMVSEHEKAINLFRKQSTDGSDAALKAFATKTLPTLEQHLQHTKEARDAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F3</accession>
    <name>C6X5F3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5 YciO YrdC YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01191"/>
    <dbReference type="EnsemblBacteria" id="ACU07641">
        <property type="protein sequence ID" value="ACU07641"/>
        <property type="gene ID" value="FIC_01191"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01191"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_0_10"/>
    <dbReference type="OMA" id="MLYPTDT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="205" mass="22662" checksum="6A51898C76D86BF9" modified="2009-09-22" version="1">MYMAKILKIYPNNPQENLIDEVVKTLQNGGIIIYPSDTVYALGCNIFDIRAMEKLAQIKKIKLEKAQFSIICNDLGHLSGFTRPIDTPVFRFLKSKIPGPFTFILEAGKSLPLAYKGNKTVGIRVPDHVIPQLIVEKLGHPIASTSVKDDDEVIEYSTDPELIAEKYDNLVDIVIDSGYGDNVASTIVDLTSGEPEIVRQGKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F6</accession>
    <name>C6X5F6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805929.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01196"/>
    <dbReference type="EnsemblBacteria" id="ACU07644">
        <property type="protein sequence ID" value="ACU07644"/>
        <property type="gene ID" value="FIC_01196"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01196"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043275_0_0_10"/>
    <dbReference type="OMA" id="KQVWLRD"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970697" evidence="1">
        <location>
            <begin position="20"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="302"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="367" mass="39162" checksum="88393C5579236A7D" modified="2009-09-22" version="1">MFRFKNIFLIVLIAAVAVSCDGFKMPKNIFDPSERAKYERRFTGPDSLMTRWKTEFSAAAQNQLQITDGYSGSVFGGSNNLYALGYSVGLKKGDLLVIEATVTAPEPKIFIDIFEAGRGAESSKTELLRNGSVTRFTENSGIHKIIIQPEIGYQGTFSLKIYTQPSLGFPVAGKANRDVQSFWGASRDGGGRSHEGVDIFAPRGTPVVAATDGYITRTGNSGLGGKQVWQRDGLLGSSLYYAHLDSIMVQGGAQVKTGDTLGLVGSTGNAKGGAPHLHFGIYSVGGAVDPYPYLRKRLKPVYKKAAVPAGKAVKAGSNLRAGPGTQFEIIATLDEKTAVNVLAGDGAWYHIKTVSGTEGFVSSSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J1</accession>
    <name>C6X5J1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805964.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01231"/>
    <dbReference type="EnsemblBacteria" id="ACU07679">
        <property type="protein sequence ID" value="ACU07679"/>
        <property type="gene ID" value="FIC_01231"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01231"/>
    <dbReference type="eggNOG" id="ENOG502Z8KF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046103_0_0_10"/>
    <dbReference type="OrthoDB" id="298101at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017645">
        <property type="entry name" value="Dnd_assoc_1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03236">
        <property type="entry name" value="dnd_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="490" mass="57692" checksum="092D5CEF7DFA773F" modified="2009-09-22" version="1">MRDIKLNIEGPNSLEKNYIKKNSFSHVTGNQIRLLPFKTNPSGDKFGEDFKSFQGIVGELFRVLNNKSQVEVGKNHETLKIELKETIIKNAVGNVDTEHIDELTHMLSKLFFDEDDGLIKFNLKTLSYMNFINSHKAIKDVARYIFDLFMKEDFSAEDLKADDSDENLLNQLMLQSLPELSTAQTISDGRSYHNLFAEIKQQFSNDFNFLKNNDSLLLKHSEDFFKYYYFHYLSQVMIIFNDFGSSPPKVRPINFTMDWETLSESRLSSHTIGWKHLNKYSQSIFAHINTLELLNYVYVDGSPLRDYHNIKMIYDTLDPMEQQEFKTCLVEVSNFYTNNITVFDTGKNWEHCEYLLNMDVYFTKLEDDILKAIYALWFKIRYQFENSPRSKPYSDYSKWYTHFVKVNYTKNRGRLGYTTVLSQELLLFLTRLCIGTEDKIRLKLLWDRLRERGIVFDETSKLEIIKLFEKINLIEKKSDSGDAQYVKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J8</accession>
    <name>C6X5J8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07686">
        <property type="protein sequence ID" value="ACU07686"/>
        <property type="gene ID" value="FIC_01238"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01238"/>
    <dbReference type="HOGENOM" id="CLU_3251863_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="42" mass="4959" checksum="6CCC218AF2B11DC5" modified="2009-09-22" version="1">MSEARQYTSFEDKPSDPRKFENLTQWFGDCKEPNFSGRNSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L2</accession>
    <name>C6X5L2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01252"/>
    <dbReference type="EnsemblBacteria" id="ACU07700">
        <property type="protein sequence ID" value="ACU07700"/>
        <property type="gene ID" value="FIC_01252"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01252"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076645_2_0_10"/>
    <dbReference type="OMA" id="WIDGQAR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="194" mass="22191" checksum="8DF6F25D91A54C65" modified="2009-09-22" version="1">MKALRSLSIMNPTFFETPAQFRVWLEQHHKTEKVLTVGFYKVGSGKASMTWSQSVDQALCFGWIDGVRKSVDAESYSIRFTPRRLGSIWSAVNIRKVSELKLAGLMQPAGLKAFSLRTEDRSGIYSHEQEPAALDQAFEDQFKKDKAAWEFFTRQPPSYRKVTVHWIMSAKQEKTRQSRLTKTIEASANGERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P9</accession>
    <name>C6X5P9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01289"/>
    <dbReference type="EnsemblBacteria" id="ACU07737">
        <property type="protein sequence ID" value="ACU07737"/>
        <property type="gene ID" value="FIC_01289"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01289"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_2_2_10"/>
    <dbReference type="OMA" id="FCCIGTT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="228" mass="25461" checksum="4A488021BA8A0FA4" modified="2009-09-22" version="1">MLWKNHRITTISLMKALIIGATGATGKDLVQQLIADPDYSEVAVFVRKPLDFNHPKLSAHVIDFNKPDEWKHLVQGDVAFSCLGTTLKAAGGKDAQWKVDYDYQYNFAKAAKENNVEDYILVSSYNSDSKSKIFYSRMKGELEEKVKALEFNKITIFQPGMLERKNSDRAGEVLGGKVIKFANSLGLFRSQKPMPTSVLAKAMINAAKIKSNGFSEIKLANIFSFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y4</accession>
    <name>C6X5Y4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01374"/>
    <dbReference type="EnsemblBacteria" id="ACU07822">
        <property type="protein sequence ID" value="ACU07822"/>
        <property type="gene ID" value="FIC_01374"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01374"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868042_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="320" mass="36691" checksum="0B776C99FA4B1C4C" modified="2009-09-22" version="1">MRVKTIHHLKNKYTAMTELNLKNLLADPQLDALSKEKLRAMYEMISAKEFSDIVDSEGNQYVNFVQEGGGVWGVALVGYLYALETFGIRFLRIAGTSAGAINTMLIAALGNRSKNKSNRIREILFSWKFEDFMDGKSIVKRVASRLLKSKNYMKKTGIAILILLITVVLFPFLMIAFKINLWWYLAPFLCLCIIIILAARYYRLFKVNNIGLNPGKAFENKMKTALENFNIRNVSNLNEEYNKSGRDLNLNYRYGNGEEYYANALEHIRNIQLQEAGNVDPVRFRAFLQSAQDSDVYRENPFTLLRSDYTIIATDINAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X608</accession>
    <name>C6X608_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806131.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01398"/>
    <dbReference type="EnsemblBacteria" id="ACU07846">
        <property type="protein sequence ID" value="ACU07846"/>
        <property type="gene ID" value="FIC_01398"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01398"/>
    <dbReference type="eggNOG" id="ENOG502ZBS5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072320_0_0_10"/>
    <dbReference type="OMA" id="DYEAVMP"/>
    <dbReference type="OrthoDB" id="2086726at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="295" mass="34503" checksum="850E02AB3EE2BEB5" modified="2009-09-22" version="1">MITRLKHAEIDFEAYARRINSSVQNNFYANREVIDLLCGRWDLLVYGDYEYIMPVPLTRKLGLNLVSMPVFIQQLGIFGPEDNVHLNELFLKKLLEIYIVESYSFNTLNTFKSNIGVRKNYIVEQQDYHLLYKKRFLKGRKSVLKKIEGLSVQVKEADRQTESFILRNFKGVKKKQDLVTFIQFIKKFCSKLQMWHVYSEDQLISVAVVTEDSKCYGLLALINDETHRSRNAASFLINEFLQQEIEHKSLDFMGGNIRGIEVFFKSFGADLVTYPVVQHSKKELIYKFLSKIIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X609</accession>
    <name>C6X609_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806132.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01399"/>
    <dbReference type="EnsemblBacteria" id="ACU07847">
        <property type="protein sequence ID" value="ACU07847"/>
        <property type="gene ID" value="FIC_01399"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01399"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073529_0_2_10"/>
    <dbReference type="OMA" id="HEEFWII"/>
    <dbReference type="OrthoDB" id="1833204at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="103"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="25116" checksum="5D5C9E943CDA83E3" modified="2009-09-22" version="1">MSIKFLAEDDRPREKFLLKGKNSLSDAELLAIIMGSGNREDSAVELSRKILKSVDNNWHNLSRLHIPDLMKFKGVGEAKAISIAVALEIGHRRAAQEIPDRVQITCSRDTYNVLSPYLSDLNTEEFWAIYLNQNNRVIGKSRLSSGGINQSVVDVRILFKSALDHLSTAIVIAHNHPSGNLKPSAEDLKITRQITDAGKILNIQLLDHLIISQNSYFSFADENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X616</accession>
    <name>C6X616_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01406"/>
    <dbReference type="EnsemblBacteria" id="ACU07854">
        <property type="protein sequence ID" value="ACU07854"/>
        <property type="gene ID" value="FIC_01406"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01406"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_1_10"/>
    <dbReference type="OMA" id="LPWNTTA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="122" mass="12880" checksum="ABF21E3570598086" modified="2009-09-22" version="1">MMNIFVSNINYSTREESLQDLFSEFGEVSSAKIITDRETGRSRGFGFVEMSDEDGKNAIEALNGKELDGKELNVSEAKPREDKPKRSFDNNRGGGGGYGGGGNRGGSGGYGGGGGSRGGSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X634</accession>
    <name>C6X634_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806157.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01424"/>
    <dbReference type="EnsemblBacteria" id="ACU07872">
        <property type="protein sequence ID" value="ACU07872"/>
        <property type="gene ID" value="FIC_01424"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01424"/>
    <dbReference type="HOGENOM" id="CLU_2477747_0_0_10"/>
    <dbReference type="OrthoDB" id="2096298at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="88" mass="10274" checksum="EEAAAE5606EBABA9" modified="2009-09-22" version="1">MDNNNFKKSQDFNNVERNQNNNPDYNEENQAVENADVRIKDVRNPEITHESVVKDAENAVPPTAWENQKKAYNDAWENNKNQQLGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X641</accession>
    <name>C6X641_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RES domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806164.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01431"/>
    <dbReference type="EnsemblBacteria" id="ACU07879">
        <property type="protein sequence ID" value="ACU07879"/>
        <property type="gene ID" value="FIC_01431"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01431"/>
    <dbReference type="eggNOG" id="COG5654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133611_0_1_10"/>
    <dbReference type="OMA" id="LPPNQHY"/>
    <dbReference type="OrthoDB" id="1821714at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014914">
        <property type="entry name" value="RES_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08808">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00953">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RES" evidence="1">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="156" mass="18360" checksum="E2131F39C21D4B73" modified="2009-09-22" version="1">MLVYRIAHKKYADSLFASGLEGRWNSEGKKVLYTAESISLAYLETMNYRKGMGYNDDFRIMIIKLPQTDFSMVSSAELPSDWRDFRNYHECQKIGDRWFDDTKNLALKVPSAVVPENYNVIINTLHQDYNKVKLIEVLPFHPDERLEKIIKKYKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X684</accession>
    <name>C6X684_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial glucokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806207.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01474"/>
    <dbReference type="EnsemblBacteria" id="ACU07922">
        <property type="protein sequence ID" value="ACU07922"/>
        <property type="gene ID" value="FIC_01474"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01474"/>
    <dbReference type="eggNOG" id="COG0837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042582_0_0_10"/>
    <dbReference type="OMA" id="NNHWRLS"/>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003836">
        <property type="entry name" value="Glucokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02685">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="349" mass="39232" checksum="F92606D4A977270C" modified="2009-09-22" version="1">MDANNKFKLYLPAILEERNNNNSLVAADVRKDKTFFAHYTTRDRKIVSSVEKAYPTQDFSSFSEIAMRFVQEHQLTAVSKIAVAVPGPVIAGKSAPLRLPWELDAEEIKHRTNIPNVYLINDLEASAYGLGNDDASSFHTIHQSDKVVPGNIAVLAPGAGLGEAGLFWDGKFMRPFATEGGHCEFSPRTNDEVEFYQFLQKLYGIVTWESVLSNDGLFNIYRFLRDVKLQQQPAWLTQEIEAGNFTEAVINGALENRDRICNMTIDTFMIFLAREANSLVLKLKATGGLFLSGEIPVMLHKYLNNDKFYKNFIVSDKMEVLLRDIPIYLVKDQKTIIQGAALYAAFSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C5</accession>
    <name>C6X6C5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsF</name>
        <name evidence="6" type="ordered locus">FIC_01516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01516"/>
    <dbReference type="EnsemblBacteria" id="ACU07963">
        <property type="protein sequence ID" value="ACU07963"/>
        <property type="gene ID" value="FIC_01516"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01516"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_4_3_10"/>
    <dbReference type="OMA" id="ITEASPM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="14511" checksum="522FC817F3333A2F" modified="2009-09-22" version="1">MHLEIFNKLFNIMNNYETVFILTPVLSDTQVEEAVQKFEDLLTSHNCEIVAKENWGLKKLAYPIQLKKNGFYTLIEFKGEGTVVADLELAFKRDERIIRFLTTKLDKHAIDYAVTRRSKNKSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F2</accession>
    <name>C6X6F2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806275.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01543"/>
    <dbReference type="EnsemblBacteria" id="ACU07990">
        <property type="protein sequence ID" value="ACU07990"/>
        <property type="gene ID" value="FIC_01543"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01543"/>
    <dbReference type="eggNOG" id="COG1718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075702_0_0_10"/>
    <dbReference type="OMA" id="HGATMIW"/>
    <dbReference type="OrthoDB" id="1347131at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="260" mass="29595" checksum="189C3460266D80E0" modified="2009-09-22" version="1">MTQDLSLRTVTVMRYILPLREGGSLPALAEADDDFKYVLKFRGGGHGVKMLISELLGGKIAELLGLKIPELVFANLDVDFGRTEADEEIQDLLKFSEGLNLALHFLSGAIAYDASVKTDPLLASKIVWLDAFITNIDRTHKNTNLLLWHRELWVIDNGASFYFHHSWMNFEKHALSPFAYVKDHVLLSQATMLDEADAFAKSVLNEENLRACVELIPLEWLQWQDTDDSPEQIKEIYFNFLKTRLENSHNFVNEAKNARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F4</accession>
    <name>C6X6F4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806277.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01545"/>
    <dbReference type="EnsemblBacteria" id="ACU07992">
        <property type="protein sequence ID" value="ACU07992"/>
        <property type="gene ID" value="FIC_01545"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01545"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_10"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="291"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="775" mass="88144" checksum="05EF5C48650B7C90" modified="2009-09-22" version="1">MDYLKGLNEAQYEAVTTLEGPLMVLAGAGSGKTRVLTMRIAHLITNLVDPFNILALTFTNKAAKEMKERIAKVVGQSEARSLWMGTFHSVFARILRSEAHYLGYPSNFTIYDTQDSLNVIRKVLKELNIDADLYKPKKVQARISNFKNNLITVKAYYNNPELIENDERANMKHMGAIYQKYVDACFKNGAMDFDDLLLRTNELLTRFPEVLAKYQDRFRYILVDEYQDTNHSQYLIVKALASKFENICVVGDDAQSIYSFRGANIFNILNFKKDYPDAVTVALEQNYRSTQNIVNAANVVISKNVQQFKKNVFSDNEEGEKIKVYRSLSDADEANFVASNIWEQHNSFQRKFTDFAILYRTNSQTRAFEDALRRKNIPYRVFGGLSFYQRKEVKDLIGYLRLLVNENDAEALSRVINYPVRGIGETTQNKLIVFADKKNVSITEILGNLGHYAPELGLNNGILTKLSDFWAMIKAFQVMLKTENAYTVAMEVAKRSGLIKFLNDDQTPEGISRVENVQELMNSMQGYIEEQQQLEDGDPSLSGFLENIALSADTQNDKKDGGDQVSLMTIHLSKGLEFPVVHLVGLEENLFPSFMSSSTREEIEEERRLFYVALTRAEKQAFFSYAVSRFQWGKITDAEPSRFLSEVDPQYLEFINPAIESRFVNHSGLKSSIFDDEPTAPRSFSKKAQKKTIERSEPQPVPQNLKPVATARIINPSGASSENIEVGDQVRHDRFGVGEVLFLDGTDPQNIKAKVKFQHEGEKNLILKFAKLTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G6</accession>
    <name>C6X6G6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01557"/>
    <dbReference type="EnsemblBacteria" id="ACU08004">
        <property type="protein sequence ID" value="ACU08004"/>
        <property type="gene ID" value="FIC_01557"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01557"/>
    <dbReference type="eggNOG" id="COG4894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324760_0_0_10"/>
    <dbReference type="OMA" id="YIKADRI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="207" mass="24098" checksum="F940B1355BBBF142" modified="2009-09-22" version="1">MGTLHIMVLENLNYPLEFRFKITTLSSDFNITDKNGNYVAYVRQKMFKLKEDVVVFNNESKSKELFRIKANQWIDFNASYAITEQSSGRNFGTLARRGMRSLWKSQYDIADGTGNSRYQINEDNGWIKVLDGFIGEIPVLGMFTGYFLNPSYTVRDNAGKEYFRLKKMPSLFGRKFQLERLIDIDDQDESLVVLSFLMMVLLERDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD7</accession>
    <name>C6WZD7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00510"/>
    <dbReference type="EnsemblBacteria" id="ACU06968">
        <property type="protein sequence ID" value="ACU06968"/>
        <property type="gene ID" value="FIC_00510"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00510"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_4_10"/>
    <dbReference type="OMA" id="VMDDFIM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="165" mass="18607" checksum="136890B0543430F8" modified="2009-09-22" version="1">MDIRFLKASEADTELIRTLAEESWRAAYSDILSGEQIDYMLAEMYSASEITLQFSNPNYQYFLLFNENEAVGFIGFENHYKASTTKLHRLYLVPAAKGKGIGKAALTFLKKTVPESGDIKIILNVNKNNPAKSVYESQGFRVYTEAVTDIGNGFVMDDYLMECVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG2</accession>
    <name>C6WZG2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781644.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00019"/>
    <dbReference type="EnsemblBacteria" id="ACU06497">
        <property type="protein sequence ID" value="ACU06497"/>
        <property type="gene ID" value="FIC_00019"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00019"/>
    <dbReference type="eggNOG" id="ENOG5032RPW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144753_1_0_10"/>
    <dbReference type="OMA" id="LHTYYAM"/>
    <dbReference type="OrthoDB" id="1634953at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046125">
        <property type="entry name" value="DUF6122"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19617">
        <property type="entry name" value="DUF6122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="111" mass="13365" checksum="2DF94A971A682CC1" modified="2009-09-22" version="1">MENVFYLRESSHYFLHFIFPFFVARLFFKENWRTAYLLLLSTMLVDLDHLWAVPVFDPNRGSIGFHILHTYPMVFLYLLGAIFLKGNYRIIAIGLVLHMVTDFQDFHLWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR8</accession>
    <name>C6WZR8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ordered locus">FIC_00128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00128"/>
    <dbReference type="EnsemblBacteria" id="ACU06603">
        <property type="protein sequence ID" value="ACU06603"/>
        <property type="gene ID" value="FIC_00128"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00128"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_10"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="626"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="756"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="391"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU06603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="807" mass="90528" checksum="2F93206844B70C4A" modified="2009-09-22" version="1">MSFLNIMAEFNDLNFEEIMDDGFAIVAEELNLEDFVETPQDKEQKVFPILPVRNMVMFPKVVIPITAGREKSIKLLEEAQRNNEFIGILSQNNPGIENPTENDLYKTGTLAKIIKIIKLPEGNVTAITRGYQRFTVKNFVTSKPYFKAEVTKLKDVSTKKTEEYNALLENIKDMALKIIDLDPNIPSAANFAIKNMSDHEDLLNFICTNANFSGADKQKLLEEKSLLNRAQKCYELMHDDFRKLELRNQIHQKTNRELDKSQREYFLNQQMRAIQEELGGGPESDVEELLLKAEDIKWNEEVDAHFKKEINRLQRQNPNSPDYNVQRNYLDFFTELPWEKYSKDVFDINKAEKVLDKAHFGLEEIKKRILEHMAVLKLKNNMKSPILCLVGPPGVGKTSLGKSVADALGRKYVRVSLGGLHDESEIRGHRKTYIGAMAGRILQSVKKSGTSNPVIVLDEIDKIGAGVHGDPSSALLEVLDPEQNHAFYDNYLEMGYDLSKVMFIATANSLSTVQRPLLDRMEIIEIAGYTLEEKVEIAKRHLIKKQQEENGLNTKSFKLGNAELKHIIEAHTSESGVRRLEKRLAAIARWVALQTALEKEYDAKLSIDRIDAILGVPRPKSLSEITGVPGVVTGLAWTQVGGDILFIESILSEGKGNLTMTGNLGTVMKESATIALEYIKAKHNELGISAEDIKANNIHVHVPEGATPKDGPSAGIAMLTSIVSSFKNKKVKPHLAMTGEITLRGKVLPVGGIKEKLLAATRAGITEIILCDANRKDVEEIKKDYLKNLKISYVSRMSEVIDLAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW0</accession>
    <name>C6WZW0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ordered locus">FIC_00170</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781792.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00170"/>
    <dbReference type="EnsemblBacteria" id="ACU06645">
        <property type="protein sequence ID" value="ACU06645"/>
        <property type="gene ID" value="FIC_00170"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00170"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_10"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:one-carbon metabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="122"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="252"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU06645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="426" mass="46790" checksum="D73CD62EFD8C9595" modified="2009-09-22" version="1">MSYLFTSESVSEGHPDKIADQISDALIDHFLAYDPTSKVACETLVTTGQVVLAGEVKSKAYLDVQDIARKVINDIGYTKGEYMFNGDSCGVISAIHEQSPDINQGVDRVEGNADFETKANAQGAGDQGMMFGYATNETENYMPLALDLAHTILRELSSLRREGNAIPYLRPDAKSQVTIEYSDDHKPIRIDSIVVSTQHDEFGSEEAMLAKIKKDIIEILIPKVKAAQKIEIQELFNDDIKYHINPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKVDRSAAYAVRHIAKNLVAAGVADEVLVQVSYAIGVAEPCGLFVSTYGTSKVDLPDGEIAERLKKIFDLRPYAIEHNLKLRNPIYLETASYGHMGREHYVASKTFNKGKSNEMTIDNLEFFTWEKLDKVEEIKTEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY7</accession>
    <name>C6WZY7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Outer membrane protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00197"/>
    <dbReference type="EnsemblBacteria" id="ACU06672">
        <property type="protein sequence ID" value="ACU06672"/>
        <property type="gene ID" value="FIC_00197"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00197"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053320_0_1_10"/>
    <dbReference type="OMA" id="YKNYQNE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970489" evidence="5">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24417" checksum="2CAA2F6FED762954" modified="2009-09-22" version="1">MKHIRLIAALLIIFSGTLSAQKIGVVDTDYILSKLPQYKDAQDRLNAQITNWQTEIQTLQSEFDKKRTLLENERVLLIGDQLKLREKEVDDLDKKIKTMINNRFGTLGEINNARSNLTKPFQDQIWNAIRTVSDKNALGIVLDKSNNISVIFLEKRYDYTDKVLDLLLKNSGSNKNSGAETNPRNQTEGRNEKIRQMNDRATTTPSQQRKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ1</accession>
    <name>C6WZZ1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00201"/>
    <dbReference type="EnsemblBacteria" id="ACU06676">
        <property type="protein sequence ID" value="ACU06676"/>
        <property type="gene ID" value="FIC_00201"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00201"/>
    <dbReference type="eggNOG" id="ENOG5030S7D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303312_0_0_10"/>
    <dbReference type="OMA" id="YLIASPH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="232" mass="26102" checksum="07C7A22CE6CA1FCB" modified="2009-09-22" version="1">MHRNLTEMKNAMWIVLLFCGQVLTAQNILLNKVEKTHTNQDKVLYKIDPEAAAAEYLGEIEVQGFSDNDVEVFGKIYAKAKQIGANAFAVKPFESVEGGAQPFDPAHYRLSLSYLPFADFPPENNAVYLIASPHNRQSVAFNKETIVFEPRTFIRRELLPGTVYTVSTKKFLGSSIRLSAQENQPVQYFQFSAFSVNSNPYGTAGINLKSGDITRLEQSYAQFLTAIYRQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ6</accession>
    <name>C6WZZ6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription termination protein NusB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781828.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00207"/>
    <dbReference type="EnsemblBacteria" id="ACU06681">
        <property type="protein sequence ID" value="ACU06681"/>
        <property type="gene ID" value="FIC_00207"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00207"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058797_0_0_10"/>
    <dbReference type="OMA" id="KTPNWDK"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="6">
        <location>
            <begin position="195"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="301" mass="35978" checksum="154817997B8D1E98" modified="2009-09-22" version="1">MLGRRQIREKVVGTVYSYYQNPLKSDVLEKNMFSQIEKIYHLYIYQLNFLVALKALAEKQIEIGKKKYIKTDDNTNPNQKFINNQVLLKLEENTERLSFTSKHQHLKWDLHDELLVKTFQRMTAGKRYQDFMKEEGYSFDADQKFIGKLFLRYIAENEDFHEHLEEKEISWSDDFHISNSMIQKTIGFLKEDEPSHTLIKMIKDEDDREFARRLLKDTLNHWEESEKKLVGRLENWDIERVSLVDKIILVTAITELDYFPLTPARVVINEYIEISKVFSTDRSNIFINGILDKYTKDFNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X001</accession>
    <name>C6X001_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781833.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00212"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06686">
        <property type="protein sequence ID" value="ACU06686"/>
        <property type="gene ID" value="FIC_00212"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00212"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_10"/>
    <dbReference type="OMA" id="AWMAREV"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023881">
        <property type="entry name" value="Thiol_BshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03999">
        <property type="entry name" value="thiol_BshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="193"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="377" mass="42385" checksum="EC94D9F0550EB9C5" modified="2009-09-22" version="1">MKIGILCYPTYGGSGIVATELGMALAKKGYEVHFISSNLPARLDITNPNIFFHKVNVQTYPLFQYQPYDIALSSMIYRVVNLYKLDLLHAHYAIPYAYAAFTAKQMLKEEGKDVPLVTTLHGTDITLVGQHPSYRHAVEFSINQSDTITSVSESLKKDTLKLFHIKKEIQVITNFIDNSEFNQATDCTRRQFATDDEKILIHVSNLRPVKRIGEVLEIFKNVNRTIKSKLIIIGEGPDMEKISQFLEENPTLISEIRLLGKVNDLYKILQLSDVFLLPSEQESFGLAALEAMAAHTPVISSNAGGIPEVNIQGVTGFLAEIGNVEAMSNYTIKLLSDEQLLVEMKENAKEQAIKFDLVNILPVYETMYKKTLEDFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X008</accession>
    <name>C6X008_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781840.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00219"/>
    <dbReference type="EnsemblBacteria" id="ACU06693">
        <property type="protein sequence ID" value="ACU06693"/>
        <property type="gene ID" value="FIC_00219"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00219"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097532_0_0_10"/>
    <dbReference type="OMA" id="YKQMKMY"/>
    <dbReference type="OrthoDB" id="1519412at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025350">
        <property type="entry name" value="DUF4254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14063">
        <property type="entry name" value="DUF4254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="206" mass="24039" checksum="C7C221D9230C4757" modified="2009-09-22" version="1">MGFSDQAWDIFNQSITDFHTEDNVDTAMQNPFVNGSLEWLLYTKNWIDTVQWHLEDIIRDANIEPAEALKIKRRIDSSNQQRTDLVEFIDSWFIQKYNNITPNEDAKINSETPAWAVDRLSILSLKVYHMSLEAHRASASEEHRKNCSNKLNVLLEQKKDLSVAIDQLLFDIENGQVKMRVYKQMKMYNDESLNPVLYQNVKNGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E9</accession>
    <name>C6X0E9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-1,3-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781982.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00368"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06835">
        <property type="protein sequence ID" value="ACU06835"/>
        <property type="gene ID" value="FIC_00368"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00368"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_1_10"/>
    <dbReference type="OMA" id="CIYIKEN"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="339" mass="39181" checksum="C51E46044D953DAA" modified="2009-09-22" version="1">MKISVIVPVYNVQDYVKQCINSIIAQTYHDLEIILVDDGSTDNSFQICKDAAGKDSRIITVSQKNAGVSAARNNGIKMSTGDYITFVDSDDWLHHDLYLSMTEILNRYPRTDVVMCDFATVKNNTAQQITSQLREGLYIKKDIISGIYPTLLVTEDFGRLPIVSACTCIFKRSFMLKNSIQFDEGLRYSEDYLFMADVMTHCDSYYYLKNFFAYNYRQYEESRSKKYQSEWWLTLISLNDKFKNLLLGTTEYDFTRQLKLQLIHSALFVSSSLNNQNLGYKEKIKLLNTVFGEPSLKSAFSELNFSGQSLSLRIVLFLMKHRMPLAYLFYMEAVSKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G4</accession>
    <name>C6X0G4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00383"/>
    <dbReference type="EnsemblBacteria" id="ACU06850">
        <property type="protein sequence ID" value="ACU06850"/>
        <property type="gene ID" value="FIC_00383"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00383"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082049_4_1_10"/>
    <dbReference type="OMA" id="VETRYNI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="1">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="168" mass="18630" checksum="3AE39DEDB0B904F1" modified="2009-09-22" version="1">MNSTLTYTLMGEKQEVDPKHSVYMSIPVEYHLHKNISLFAELAGAGLGGENLVLPNGQRTRLHLTTIYFPVGVKLYPVERFALVGAYNFGLITNALGEQNGEDVDFEDLKNGNSSFSFGAEYKFRSGVAAEVKYNIGTSNIAKTIPGMEMKNNFLQIGVGYYFDDNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0R6</accession>
    <name>C6X0R6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00492"/>
    <dbReference type="EnsemblBacteria" id="ACU06951">
        <property type="protein sequence ID" value="ACU06951"/>
        <property type="gene ID" value="FIC_00492"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00492"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066614_0_0_10"/>
    <dbReference type="OMA" id="EEQNNWF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="53"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="394" mass="45869" checksum="298B0933C6292F20" modified="2009-09-22" version="1">MMQMLSLKKVSVSKRRSSRWRMTCGITKQHGNNNKPEYLCSGFFIPKLMVNVDYIVVGGGYAGLFFAHQLIKNKKTFVIFTGDRKSASRISAGIVNPVVLKKFTTFWLAKEQIEALHRTLNEISGYTRENYLIRENIQRIFHDENEKDLWLQKSESEELNPYLNPYFKQLDVILNPFGTGTVDQSARLDVNAFFKGLNEYLSAHDHVHEEAFDYTALQDHNYRKFTFKHIVFCEGMGVRKNPFFAEIPVIPNKGHHLKVSLSERLHHQFTLKKKHFLFPLDEKFHYYGGTYDPNERPDEVDAHATQQLRDGLSEFYPHAFEVEEVNFALRPTVKDRRPILGSHPRQPNYYVFNGLGARGILNGCYFSEILFEHIEHGKPLIPEVDLNRFTVKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0V6</accession>
    <name>C6X0V6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MiaB family protein, possibly involved in tRNA or rRNA modification</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01624</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01624"/>
    <dbReference type="EnsemblBacteria" id="ACU08069">
        <property type="protein sequence ID" value="ACU08069"/>
        <property type="gene ID" value="FIC_01624"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01624"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_1_0_10"/>
    <dbReference type="OMA" id="HFHIPLQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="148"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="454" mass="51169" checksum="87BE96B32625F1C8" modified="2009-09-22" version="1">MQPHYMETLQPKTAAYHTLGCKLNFSETSTIARQLTGAGYQKVGFDDKADVYVINTCSVTENADRECKYHVKRAMKANPDGLVVILGCYAQLKPEEISAIEGVDLVLGAKEKFNILSYLGDLQKTANHGLIHSCEIDETDFFIGSYSIGDRTRAFLKVQDGCDYKCTYCTIPLARGISRSDTIENVVQNAAEIAAKGIKEIVLTGVNIGDYGKGEFGNKKHEHTFLDLISELDLVEGIERIRISSIEPNLLKDESIELVARSKRFVPHFHIPLQSGSDDLLKKMKRRYLTALYSERINKIRSVVPDACIGVDVIIGFPGETEEKFLETYRFLSDLPISYLHVFTYSERENTEAAAMDGAVPVPERKRRNKMLRILSEKKKMAFYQSQTGKTLPVLWEHENKNGLMYGFTENYVRVHKTFDPSSVNEIEFVTLRELHEDGSVSVDSAFSEFLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X115</accession>
    <name>C6X115_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806413.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01685"/>
    <dbReference type="EnsemblBacteria" id="ACU08128">
        <property type="protein sequence ID" value="ACU08128"/>
        <property type="gene ID" value="FIC_01685"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01685"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_2_2_10"/>
    <dbReference type="OMA" id="IAWVGSK"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="43"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="219" mass="23824" checksum="F39AFA9747484A0D" modified="2009-09-22" version="1">MNKLSTVLVSSMVAAAISLTSCGKDKPLTSESSDVTTTKEGSIFELDTLNSRVEWKGFKVVKTDNTSHFGTIKFESGEVTVKDGELESGKFVADMNSLTSVDLKDDAEQLAKLNGHLKSGDFFEVEKFPTSSFEVTKITKNSTGDYNTTIDGNLTIKGITKPVKFNANVSVSEGDVSIATEPQDINREDFGVKFQMPVANGIIKNEVNLQIVIKALRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X125</accession>
    <name>C6X125_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
            <ecNumber evidence="3">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806423.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01695"/>
    <dbReference type="EnsemblBacteria" id="ACU08138">
        <property type="protein sequence ID" value="ACU08138"/>
        <property type="gene ID" value="FIC_01695"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01695"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_14_3_10"/>
    <dbReference type="OMA" id="YRDPWYG"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3471" evidence="2">
        <location>
            <begin position="417"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="516" mass="57482" checksum="05AAC98EA4B4A432" modified="2009-09-22" version="1">MKRNLSLLFVLISLCAFSQIEEKKLDDLIQNTLKTFDVPGISVGIIKDGQTVYAKGFGVSSLTSMKKMDENTLVGIASNSKGFTGTALAILADEGKLSFDDKVIKYIPEFRMYDPYVTQEITIKDLITHRAGPGLGQGDLMFFPEGGNLTVNDIIHNVRYLKPENSFRATLDYNNIMFIVAGEVIHRVSGLSWAEFIEQRIMKPVGMNSSYGSYSRAKAAKVQNIIDAHAPVDGKAVAVPHDWNETANAAGGIISNIKDMNTWAEFLMNGFITKDGKKLVSDKQIQQLWNLQISTPVALKNSYDSNFGGYGLGWFLTDVKGHKQVYHTGGLIGTVTQFTLIPDMKLGIVVLTNQQSGAAFTAITNTVRDAYLGIEDRNWLKSLGERMAKTNESFEKGKREIFAQSDAFKKDKKLQPQPEQFVGTYTDAWFGDVIISKEGAGFRIICKNSPRLKGTLLPYSHNTFIAKWDDRSYDADAFVIFSYDEKGKAQSAKMKPISDITDFSFDFEDLDLQRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X171</accession>
    <name>C6X171_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01741"/>
    <dbReference type="EnsemblBacteria" id="ACU08184">
        <property type="protein sequence ID" value="ACU08184"/>
        <property type="gene ID" value="FIC_01741"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01741"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_4_10"/>
    <dbReference type="OMA" id="WWLENPN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="29"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="378"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="651" mass="71811" checksum="5A4520C60F281CCB" modified="2009-09-22" version="1">MLIMKNFNKKLVVGVILASMTFAGCNNVLEEEPRGIYTPNDFNTEQGIRQGVTALYRHMRLLYGNGYWMSANVNGTDEATYAQSADGNFKEMDFSGAGTLNTATFPASMVWSAVFPYINTANGIIQNGSSVGIAESLVSEARFFRAFDYFLLVQTYGGVPLDLGSGELTFNVTPSTTSKRNTVPEVYTKAIFPDLLTAVENLPVTPRVTGGVTKNVARLQLAKAYLTYGWWLQNPNGIPTYPETPRTDPDGKTAQWYFQQAYDVALAGINNPGSYSLQPTYYDVNLGANDRNSETMLYADHTQNSAYYNEGDPFGFASGWSPDNFAAWIVTFNYTNLRSSSSPTTWTGVSSVQRAATQDLGRPWTRMAPTIGAITNTFDDKTFDSRFDGTFQMVYRGNWNKAGNTAQTLYNANNLPVKQGDAILSFLNDDSQAANIVYPSGAGQNNIGAGVLPGRADFVIAPSHISRIVYPGLWKIGTYRSDDPNGLGYPNAGLTRPAYAAKFSEFYLVAAEAAVKGATGPRTARDLVNVLRARAGKWRWDNNGNVEKVADYSAQMVAATPATITIDYILAERSREFYGEGYRWYDLVRTQKWGEYATTYKIAGSNYGDHTAQTVTRAIQPHHYLRPIPQSQFDLMEMTDAEKAAYQNPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X194</accession>
    <name>C6X194_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable tonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806492.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01764"/>
    <dbReference type="EnsemblBacteria" id="ACU08207">
        <property type="protein sequence ID" value="ACU08207"/>
        <property type="gene ID" value="FIC_01764"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01764"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_13_2_10"/>
    <dbReference type="OMA" id="DTRWTHR"/>
    <dbReference type="OrthoDB" id="514956at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="42"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="268"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="676" mass="76174" checksum="AEF0CB1126E88F77" modified="2009-09-22" version="1">MNLKTAPFLFFALYTHAQQADSVKLISEVQIDAYRKPAKLITSTKSVSVAQQNILNQNSPDRLLESVNLMPGSRMEERSPGSYRFSVRGSTLRSPFGVRNVKVYLDDFPLSDASGNTYLNVIDPELLSEIEIYKGPEGGDFGAATGGTALLRTARSAKTSFGVAGGSYNMFKGRINHSQEQGNHFYQIYSSYQTTDSYRDQAALERKFLFLKDRINYAGSNQLQAMLMLSDLHYETPGGLTLQQMTDNPRQARPKTSATPGAEEQQAGIYNKMLFAGASNLLNLTDGFSHFVAVHISYSDFRNPFITNYEKRYENNVGLRTHLNFEKSYPQSFYQTRLGFEGASAKILVRNYDNNFGTAADPQNFDEIFTKSGFIFLSQKAEFSDRLFLDVSGSLNLTNYRWESAFPTMETGEKKFKNDFLPSVGVSYLISDRFSVRGKISKGNSTPTTEEIRSSAQEINQNLDAEYGWNKEIGIRKQWGNALFTEVSVFDFQLKNAIVRRENSEGQEFFVNAGETVQQGIEFIVETKKLNLNSTLLNSLKFYISGTFYDFTFKNYQKNGDDFSGNKLTGVPTTSLQNLINIEVLNKIRIDIAHFYTSSTPLNDSNSVVAEPSFIGNISVNYPITVWNSALNLQLRIQNLYNTKYSLGYDINAFGNRFYNPATPRNYMVGVNLQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X198</accession>
    <name>C6X198_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01768"/>
    <dbReference type="EnsemblBacteria" id="ACU08211">
        <property type="protein sequence ID" value="ACU08211"/>
        <property type="gene ID" value="FIC_01768"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01768"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_2_0_10"/>
    <dbReference type="OMA" id="PGWRWLH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="54"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="299" mass="33053" checksum="61A6A4015840BC7C" modified="2009-09-22" version="1">MRIIPQLRHRIWSQQLKINTMEQSKDNKIIPMTSVDSGKLREVTPDVAYYTNQIVNLVMIGKPGESWVLVDAGMPKSASEIIEVAEQRFGKNTPPTAIVLTHGHFDHVGSIVGLIDKWNVAVYSHALEVPFLTGRQAYPEPDVTVQGGMLAKISSIYPHEPINIQEVLRELPPQGAVPFLEDWQWVHVPGHSPGQVALFREADGLLISADAFVTVEQDSLYKVLVQKEEVCGPPVYLTTDWGAARQSVEKLAALNPQTVIPGHGTAMSGVGLKKGIENLLTNWDEVAVPDYGKWVRENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A3</accession>
    <name>C6X1A3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806501.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01773"/>
    <dbReference type="EnsemblBacteria" id="ACU08216">
        <property type="protein sequence ID" value="ACU08216"/>
        <property type="gene ID" value="FIC_01773"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01773"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019083_0_0_10"/>
    <dbReference type="OMA" id="CDIDCDR"/>
    <dbReference type="OrthoDB" id="1699198at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032287">
        <property type="entry name" value="DUF4838"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16126">
        <property type="entry name" value="DUF4838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972205" evidence="2">
        <location>
            <begin position="20"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="739" mass="84183" checksum="6749ED75E1026BD4" modified="2009-09-22" version="1">MKFLSVFIIIFMTAGAASAQQINATLVTNGASTYEILLPEQPNANEKKAAQVLQHYIKTVSGAELKVTTIYTAEKPIISVGRTLFAATFLPHDEFAVKSSDVNIVLYGDDSRSILFAAYHFIDVYLKCRKWAPYEPADCPVNKAIHIPLPIDISEKPSFIYREIYSTAEQDQEYMDWHKLQRLDDLWGLWGHSYFKLVPASNFSAHPEYFGLFKGRRRPLQLCLSNENVFDVAVQTLENLFKDDPAKKYWSVSANDDIGHCECDRCTTVNAAEGGPQGTLIKFINRIAARYPEKTFTTLAYGATARPPLQAKPLSNVTVFLSSVDVSRNEPVSVEKSAAGFRRNLDGWLNITPNVFVWDYYTQFTNYLAPFPDLLNAAPNVDYYQEKQVTGVFAQMGGHDYVDQSDLKTYILARKLWNHEADNSLLRDHFLAGYYGVAAAPVKTYILKLHSYLEESGKKLGIYGNPIGEFNSYLTPEKMTEYYALLDEAEKLADDKKIVSRIGKLKLSLDYTNLQQAKFYGREASGIYTQRRNGSWTVKKSLKRKVQQFGKDLEVYGITALSEAGYTAENYAREWYGILKKEPRTNLATGSDVTFENPWIPDYPAKRHRTLTDGMFGLNDFSYNWLLFDENTDILIDLKELKQVKSVSPSFLEDQRHWIFLPKLVKVSVSADGVIYRELPAPEFILSEQYKVEPHEVVFKVGAKIRYIKLLFEPLEALPEWKSHPFKTPLAAIDEIWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E1</accession>
    <name>C6X1E1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806539.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01811"/>
    <dbReference type="EnsemblBacteria" id="ACU08254">
        <property type="protein sequence ID" value="ACU08254"/>
        <property type="gene ID" value="FIC_01811"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01811"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_10"/>
    <dbReference type="OMA" id="DSARMMD"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="21573" checksum="6E64B4743737267D" modified="2009-09-22" version="1">MDNAELLSLIALARNRNQKSQTKLINLFWVDVFSFIMKKVQDENVADEITVSVFSKVLAKLDLYDPSFQFKTWILTIAQNTVIDYWRKKNRESEDSTDSFEGIKNNFARSPEELLISEEDHKKILSTIESLDTNYQVIIRLRFFEEKSIKEIADELNLTVANTKVRIMRAKKVLAELLKSNDFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F0</accession>
    <name>C6X1F0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane fusion efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01820"/>
    <dbReference type="EnsemblBacteria" id="ACU08263">
        <property type="protein sequence ID" value="ACU08263"/>
        <property type="gene ID" value="FIC_01820"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01820"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_1_10"/>
    <dbReference type="OMA" id="LDYIAPK"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="52"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="398" mass="43656" checksum="906FDAF80FCD7D8B" modified="2009-09-22" version="1">MKKKFTLKKGIYIFLGLIFAVALISGISYLITSNTKESETFLTRKPMVQNMDDKVMATGDIVPREEIEIKPNMSGIIDKILVDEGDQVTAGQLIATLRIVPSVQNVNAAQQEINNANLQISNARMTVNNQQQQFAMQQKLYTQGVISKQEYITAQQQLVNTQQQLRNAQQQLQTAQKNLQIARTGATPELAGLATTQIRSKANGTVLEVPVKVGSQVIEANSFNAGTTIASIADLNSLIFQGTIDEAQAGKLKEGMEMNVVIGALQNKTFPGRVTMIAPKGKDENGTIKFPIEGDVFNKTNEYIRAGFSANGEIILSSQKNALLLDESLIQYEKINGKDNPFVEVKQPDGKFKKVNVKLGASDGINVQILSGITKDAEVKVWNPSDKDKEALKEKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H6</accession>
    <name>C6X1H6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806574.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01846"/>
    <dbReference type="EnsemblBacteria" id="ACU08289">
        <property type="protein sequence ID" value="ACU08289"/>
        <property type="gene ID" value="FIC_01846"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01846"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_5_1_10"/>
    <dbReference type="OMA" id="IPEWEQV"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="19156" checksum="7A949BE29B920F49" modified="2009-09-22" version="1">MEKAAILKEIIENRRSTFPKDYTDEEIEESVLTEILSSANFAPNHKKTKPWRFKVFKGQEKADLGNKMAEIYRDTTRPEVFLEKKHASISEKASKANAIIAISVNFSGLVPEWEEIAATAMAVQNMYLTASAYNVGAYWSSPGIIKHLDEFLGLEENQKCYGLFFLGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I2</accession>
    <name>C6X1I2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806580.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01852"/>
    <dbReference type="EnsemblBacteria" id="ACU08295">
        <property type="protein sequence ID" value="ACU08295"/>
        <property type="gene ID" value="FIC_01852"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01852"/>
    <dbReference type="eggNOG" id="COG3088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929592_0_0_10"/>
    <dbReference type="OMA" id="FYVELID"/>
    <dbReference type="OrthoDB" id="1224824at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="298" mass="34636" checksum="38ABAF017FC48E66" modified="2009-09-22" version="1">MKKIYLVLFLLTGLFAFAQTLGSRLEKRTLALGEVAVLQITVSDLQGKDVVSAPKNELLPFHFEEVKDSISKQHDVYERVIEFAVFEEGKFTIPALDFTIGGTLFHTIPYEVEVVNTAQKGDKINDIMKNKEVKLGVTDYWELYKWYILAFLVLLALIFIIYQIVRYVRRRKDSPVMMTNQTLRDLETLKKKNYIENGDYRSFYVELIDISRNFITKQYKIPADVLLTDDLIDVMKLNNTISPENEQIIEEIFLRGDLVKFAKTFPDQDAMQKDYNDMRAFVKRSSKDLEAEQLRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I9</accession>
    <name>C6X1I9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.33" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01859"/>
    <dbReference type="EnsemblBacteria" id="ACU08302">
        <property type="protein sequence ID" value="ACU08302"/>
        <property type="gene ID" value="FIC_01859"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01859"/>
    <dbReference type="eggNOG" id="COG3407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_0_0_10"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MDD_C" evidence="4">
        <location>
            <begin position="214"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="359" mass="40307" checksum="3D356D1703242BB7" modified="2009-09-22" version="1">MPHAKNSIQMKEFFSTDSYKISDSKVTQSCPSNIALIKYWGKYAGQIPANPSISYTLNNCKTNTSIEFIANEKFSVQTFLSGNEEAKFAEKIEKFFHTIEQYLPWILQGKYIITTQNTFPHSSGIASSASGFGAIAKCLMDLDEQFSAPHGCDFKLKKASFLARLGSGSAGRSLYDGLVVWGKTDEVAGSSDLFAVPYPENEVHSVFRSFNDWVLLIHEGEKSVSSTIGHSLMNTNPYAERRFQQAHENFTLLKDILKTGDLAAFIKLVEHEALTLHAMMMMSDPAFILMKTGTLNVIHKIWEFREKTGLPLFFTLDAGANVHLLFPANTDEDNIKEFITRELLQHTQNEGVVKDVMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J5</accession>
    <name>C6X1J5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806593.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01865"/>
    <dbReference type="EnsemblBacteria" id="ACU08308">
        <property type="protein sequence ID" value="ACU08308"/>
        <property type="gene ID" value="FIC_01865"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01865"/>
    <dbReference type="eggNOG" id="COG2839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109297_0_1_10"/>
    <dbReference type="OMA" id="KWGQIGA"/>
    <dbReference type="OrthoDB" id="2021661at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="161" mass="17492" checksum="55D0677B98E784F0" modified="2009-09-22" version="1">MDHTLINLLSIVLLIVGILGTFLPVLPGLLLSLCGLLIYKFGTDADLSMVYIWIFVVLTLISIILNYVIPAKTTRKYGGTRWGSIGSVVGTIAGMFFIPVPFGFLIGMFAGVFFGELLHDASDKKKAWNSTKGALVGFLYGTGFNFIVGLAMFLVVVFDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K6</accession>
    <name>C6X1K6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806604.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01876"/>
    <dbReference type="EnsemblBacteria" id="ACU08319">
        <property type="protein sequence ID" value="ACU08319"/>
        <property type="gene ID" value="FIC_01876"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01876"/>
    <dbReference type="eggNOG" id="ENOG5033ZEJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048687_0_0_10"/>
    <dbReference type="OMA" id="NDTANWP"/>
    <dbReference type="OrthoDB" id="1880704at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972218" evidence="1">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="27818" checksum="F7E649F9C966C60B" modified="2009-09-22" version="1">MKKTLLFMLMGLISITSTANAQISMPKTWDFANDTANWPLSAGTGVPEKTVDQLGLFSKSDGSITNFAAITATSYTFSDGYTGANRLQLNGAGYTSSTGFVPLPTQRYMYFDVTGTATVTVWFRSGSNSSSRTVFVTNGSTVLGQAATDTAGTGVIFTANKTSSGNERLYVFADASCNIYKITVTGATMATGDINNAGTKVFANGSEVRVSNITTATDISVYSITGGLVKSLQANTDVAFTLKTGVYIVNTKSAKGVKSQKVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M0</accession>
    <name>C6X1M0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxaC</name>
        <name evidence="7" type="ordered locus">FIC_01890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806618.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01890"/>
    <dbReference type="EnsemblBacteria" id="ACU08333">
        <property type="protein sequence ID" value="ACU08333"/>
        <property type="gene ID" value="FIC_01890"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01890"/>
    <dbReference type="eggNOG" id="COG1904">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044465_1_0_10"/>
    <dbReference type="OMA" id="TDHGHPT"/>
    <dbReference type="OrthoDB" id="167900at2"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="466" mass="53286" checksum="E2FBD9AF9B54F70A" modified="2009-09-22" version="1">MSTNFIHDNFLLENKYAEELYHNFSKNQPIIDYHNHLSPALIADNHVFGNITEAWINGDHYKWRAMRTLGVNEKFITGDASAKDKFLQWGKTVPYTVRNPLFHWTHLELARYFDIYELLNENSAQKIYEEVSAKISTPEYSTQNLLTKMNAELVCTTEDPTDNLAHHQKLAAGDFKVKVSTAFRPDKAILIENEGYNAYLNTLAEVSETQINSYTDLCDALTKRITYFHENGCRLSDHGLDQIYSVSFTENEVSAIFKKRREGSQITTEEALKFQSSVLVFLAESYHAVGWVQQFHLGALRNNNARMHRILGPDTGWDSIGDLPQAQQLSAFLNRLDSSDKLTKTIIYNLNPADNEVFATMIGNFNDGSVKGKVQLGSGWWFLDQKDGMTKQLNALSNMGLLSCFVGMLTDSRSFLSFPRHEYFRRVLCNLLGDEIKRGELPDDMEWIGKIVSDISYNNAKEYFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T4</accession>
    <name>C6X1T4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01955"/>
    <dbReference type="EnsemblBacteria" id="ACU08397">
        <property type="protein sequence ID" value="ACU08397"/>
        <property type="gene ID" value="FIC_01955"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01955"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244017_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="210"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1607" mass="170387" checksum="75954CA1391C766E" modified="2009-09-22" version="1">MGVLINFVIHTNDMKKYLPYFFRLAVYFSLVFSVSFSGQILFTNPITGINPNTANPYTTGQYVVPNITVSGIGRGSGIAASNAADRYNASGWNSLSLEANDYFEFTLTPNPNFKINFSDFVYTGEKSGTGPTFFAFRSSLDSFTSDIGNPTATGATISLSAAAFQNITSAITFRVYGWGASGAAGTFSINDFTFNGTVLSTIIKPEPSDFPSSFNCLVSNSNSIQLSWTDATGTSVPDGYLVKWSSVSYAAITNPADGTAVVNGPGEQNISQGVQTFSVSDLTPSTTYYFKIWSYTNSGTDIDYKLVGEPQTSCTTMAPPCNFTEDFSNLSASNANTYTDRFWSGVGGTWTATDARTDQVINDKAITIRAGVVTSPVFTNGVSSISFNAKFPFNDTSGNLLLKVNNTIVGTLQASQMPTDNSVVEKTFNNINIPGTVIITLESAGARYAIDDLTWTCFTGTAQPNINIQGNATTIVNGDTTPAGNDLTDFGAAIIAGTDVERTFTIKNLGSATLALANPAVSLVSGSSGFSVSAQPSASNVPAFSSVTFKIKFNSMIPGGHTGTVQIASDDPDTPLYTFLVAATVAQPLITVDKTSLSGFTYPLAQGPSALQSFKVNGSNLAADITVTASANWEISTNQTYDANNVAPWTSLVLTKTQTGAVTNKTVYVRLKDGLPVGSYSGTVTLTSPSAVSKTVNLSGQVTVGIVEMKVTGNGTTINNGSATASGLNNTLFASQNLGESQTKGFEIKNLGGAPLTLGAITIMGADATAFSILNGPASGTVLNQNQTAAFQIRFAPTTIGTKNATVSIANNDPNDNPYTFAIRGGAVYCSSPGEIVVAVQDFETTAPPAVMNFTRTNIGSLAPGLGSGFTIGDSGNNSSPKNNKLYSEGSRGYRVQGADPIGETASGLMLIFNEVNTSSYTNLSLSFKIAGFSLGSSSNGMDSKNADSDPELIPDDTKIDHVLVEISPDGGANWYRQAKVVSDQLNLAWSFGSDFTAQASRAYSADNNLTYFKSTSMARYSAVTINNLPSVSSLKVRISLQNNALNESWIIDDIRIMSTGLVPKVWNGSSWSPSAPQPSDKAIFAGDYNTAVDGGFTACQCEVSSGATLTVSGVGAVKASDVLVNNGNVIVESDANLVQVNESDSNSGTGSFRVNRKINLSANRQQYNYLISPALDWNMKDIYKDSAGNPVNVPFILYHNEATNTFANSSGAFIKGRALAVKEPTANFPASEINAVFEGKPANGAFVYSLSNSNPNNPKRGFNLIGNPYPSNMDLIKFYQNNTESNTLSPTFYFWDNTANTQIKQMGDQYEGQAYATFNAATPPGEGTPLEATGDPGTATLKVPTRYVKVAQGFMAKLIGASQMDLKFNNNIRSAESAEGFFGKEAADQPDRFWLNMANSSNIASNIAVVYFAGGNNAYTMHDSQSMGGSDVIYSLVDGEKVSINGKSDFTTDDVVALGTTHFTSGTYSISLDRAEGVFAKGQQIYLKDKLNGIISNLSEGSYAFSAAGGETMSRFEIIYKLGTVLASENNPKDNISVYKSGHDFIVKAQFTKITTLELYDAAGRLVHTSHPNDTEASIDTMNFSQGLYVLRINQDGVLTSKRLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U5</accession>
    <name>C6X1U5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01966"/>
    <dbReference type="EnsemblBacteria" id="ACU08408">
        <property type="protein sequence ID" value="ACU08408"/>
        <property type="gene ID" value="FIC_01966"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01966"/>
    <dbReference type="eggNOG" id="ENOG5033T2C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095611_0_0_10"/>
    <dbReference type="OrthoDB" id="1331289at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973605" evidence="1">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="256" mass="28847" checksum="8E33DC7C2B00D212" modified="2009-09-22" version="1">MMTGNRLLCIMLLLAGSMLMAQQKKKDYTHILRSTSIYEIDAFLRDAHPDDPKRSVLKPRLVKMLKEYIKNAHPADQRVKDFQEKIALLRRKPSTRISFEEMNEMIRQKQIAKFKEQLQQGRTYMTKVYGNSSASAGAATGYTDTEQEEFNMLMAVNPTDYKNNTVKVLNALFDNDPNSKESIVLIENKSLCNMIMRIEGVGNTKYRLAVPAQSDNTIVVAKGDYLFSGLVCGAQYASQKTVQKAIMVSLGDAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V0</accession>
    <name>C6X1V0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01971"/>
    <dbReference type="EnsemblBacteria" id="ACU08413">
        <property type="protein sequence ID" value="ACU08413"/>
        <property type="gene ID" value="FIC_01971"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01971"/>
    <dbReference type="eggNOG" id="ENOG5032TDN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793051_0_0_10"/>
    <dbReference type="OMA" id="PRMKLKF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972229" evidence="1">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="161" mass="17952" checksum="72D50023694D43F1" modified="2009-09-22" version="1">MCMKILRFLLLSVFLLSLFSCGSDDDICLSGEATPRMKLKFKTQSSGKLKTLDSLFVNVDYGNGQVPVIAARQKTDSVFIPLRVDDVPVTRIFVGLSRTSVPSEIQLNYTTKSEYVSPACGIRKVYENVIGTVEVVNEVTGLEQNQTQITDESKTHFFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V8</accession>
    <name>C6X1V8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806706.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01979"/>
    <dbReference type="EnsemblBacteria" id="ACU08421">
        <property type="protein sequence ID" value="ACU08421"/>
        <property type="gene ID" value="FIC_01979"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01979"/>
    <dbReference type="eggNOG" id="ENOG502ZBK6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1575646_0_0_10"/>
    <dbReference type="OMA" id="MYGEPCS"/>
    <dbReference type="OrthoDB" id="1695328at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018914">
        <property type="entry name" value="DUF2480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10652">
        <property type="entry name" value="DUF2480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="168" mass="18952" checksum="48CAA055BF51FE13" modified="2009-09-22" version="1">MSEFEIKNKIADSGLVNFDLSKLVPQGRRVGIDLKDFLWEGLILKEKDFRDKVAAISPEEFSGSYVYIYNSAEAIVPLWAYFLLTSKITGEAKKIVYGSREDLEVLLMHTAIQTYDFTELSGKRILVKGCSDQSIPENAYIELVEQLKPIAKSLMFGEACSNVPIFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1X7</accession>
    <name>C6X1X7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ordered locus">FIC_01998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806725.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01998"/>
    <dbReference type="EnsemblBacteria" id="ACU08440">
        <property type="protein sequence ID" value="ACU08440"/>
        <property type="gene ID" value="FIC_01998"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01998"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_10"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="14131" checksum="C382EE96F03F8E8C" modified="2009-09-22" version="1">MARISGIDLPKNKRGVIGLTYIYGIGRSTSSEILKAAGISEDKKVNEWNDDELALIRNFITENIKVEGELRSETQLNIKRLMDIGCQRGIRHRLGLPLRGQRTKNNSRTRKGKRKTVANKKKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X203</accession>
    <name>C6X203_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806750.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02024"/>
    <dbReference type="EnsemblBacteria" id="ACU08466">
        <property type="protein sequence ID" value="ACU08466"/>
        <property type="gene ID" value="FIC_02024"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02024"/>
    <dbReference type="eggNOG" id="ENOG5033283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347237_0_0_10"/>
    <dbReference type="OMA" id="NTEMARE"/>
    <dbReference type="OrthoDB" id="1231948at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="203" mass="23652" checksum="E1507E41C6C10131" modified="2009-09-22" version="1">MKTFFLALLAFVIVSCSGEGKKKRGVDYQKFKTEVTLTADQEKSYDEITGRYQKQAEQNFEAAKAQGGQMDRVALAIKSEEMREKQAEEMAKVLDPAQMEKFNTYVDKNSRKRPRYTNQLLEQIKTKTQLSDDQFAMLNAANDAFEKSFNDAHDVYHGNTEMAREYWTKFDNQRKQALKKVFTPEQHARYLEIVKDQSFKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X224</accession>
    <name>C6X224_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02045"/>
    <dbReference type="EnsemblBacteria" id="ACU08487">
        <property type="protein sequence ID" value="ACU08487"/>
        <property type="gene ID" value="FIC_02045"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02045"/>
    <dbReference type="eggNOG" id="ENOG502Z7PX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040643_0_0_10"/>
    <dbReference type="OMA" id="YVIYGYA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973358" evidence="1">
        <location>
            <begin position="21"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="466" mass="51472" checksum="BE97C1DD386A6B16" modified="2009-09-22" version="1">MNKVRLIFAASFWLLLTAMACNRDDISFESPSQLLRFSADTLFLDTVYNQVRSETYAVKIYNDENSDVMIPKISLETGAASLYRINLDGKAGTEFTNVALRKKDSLFIFVEIAPVANATEAIAEDRIQITTPAGNQHVTLFSVVQDAEFYIQTEDNPNVLSENTSWNSDKAKIVFGDLTLKEGKTLDIQQGTKVYFYKNSALKIAKNATLNIAGDLNKEVIFRGDRNDTRYDTIPKNWQGISFESGAKLNMNYARIFGGTRGLEMTETTAVINNTIIHTHQEYGIYALNSNITAANLVMNNCGEATLGIFKGGTYNITHSTLANYWNLNSALAGLGIYATNEYQNGTSLENAALTLNLRNTIVYSDKDNAVVFKPTSGQTFNYVIQNSLLKYGSNAGFNFDGNANITGSIKNEDPKFENYFTQKMNLRVKDDSPARGKGNIAAAQAVPLDIVKNSRLSSPTLGAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X256</accession>
    <name>C6X256_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806803.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02082"/>
    <dbReference type="EnsemblBacteria" id="ACU08519">
        <property type="protein sequence ID" value="ACU08519"/>
        <property type="gene ID" value="FIC_02082"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02082"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_10"/>
    <dbReference type="OMA" id="NQRRDQY"/>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="2"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="348" mass="38649" checksum="81E1A15F2476AD0C" modified="2009-09-22" version="1">MLYTPIQFRNLTLKNRWVMSPMCMYSCEDGLANDFHLLHYGSRAQGGTGLIMVEATGVVPEGRITNKCMGIWNDEQAEKLKKVVSIVHENSESKIGIQLAHAGRKGSTWNGKQISVEEGWETVAPSAIPYHQSERIPHELTAEEIKNLVQSFKEAAQRALDAGFDVIEIHAAHGYLIHQFLSPLSNVRTDEYGGSFENRSRFIIEIIDAVNGLLDENHPLFVRISGTEYAKDGWNIKDSVELAKVLKEKGVDLIDVSSGGNIHGAKISLFDGYQVPLAASIKKESGIATGAVGLIKTAKQAEEILQNEQADLIFVAREILRNPYLPVRGSFKNNDNCFFPPQYERAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X263</accession>
    <name>C6X263_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806810.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02089"/>
    <dbReference type="EnsemblBacteria" id="ACU08526">
        <property type="protein sequence ID" value="ACU08526"/>
        <property type="gene ID" value="FIC_02089"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02089"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034095_0_0_10"/>
    <dbReference type="OMA" id="GTEGAEM"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16016">
        <property type="entry name" value="AP-SPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026263">
        <property type="entry name" value="Alkaline_phosphatase_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031924">
        <property type="entry name" value="Pi-irrepressible_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphothreonine intermediate" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR031924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR031924-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR031924-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="548" mass="60789" checksum="D9DD871CC1863AF6" modified="2009-09-22" version="1">MFRKIQVIGMIVIAAVSLNAQKTKNTAPEKPKLVVGIVIDQMRWDFLYRYESKYGNGGFKRLMNDGYNLNNVMINYVPTVTALGHTSIYTGSVPSIHGIAGNDWTDRETGKNVYCTTDTSVKGVGASSEKIGAHSPHNLWSTTITDQLGIATNFRSKVVGISLKDRASILPAGHNPTGAFWFDEGTGHFVTSSYYMNELPQWLKNFNAQNWGEKLVANGWDTTLPINQYTESTADDVPWEQLLGSAKTTTFPYNSLASDYATKKGIIRTTPFGNTLTLKAAEAALDAYNMGRNTDTDFLAVNIASTDYVGHSFGPNSIEVQDTYLRLDKDLEAFFNMLDKKVGKNEYLVFISADHGGAHALGYMEANKMLTGLFDDGLQKNLEEELKQKYSYEKLIWGIDNYQIYLNHGLIRQNKLDANEIKENIIANLNRNPRVLYAVDLAKVRSSSIPEPIKSRIINGYNWQRSGDIQIISHDGMLPSYAKKGTTHSVWNSYDAHIPLIFMGAGVKKGTSSKPYSMTDIAPTIAQILKIENPSGNIGNPISEAIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X267</accession>
    <name>C6X267_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08530">
        <property type="protein sequence ID" value="ACU08530"/>
        <property type="gene ID" value="FIC_02093"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02093"/>
    <dbReference type="HOGENOM" id="CLU_3328173_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="38" mass="4387" checksum="6EEC1CACE678E19B" modified="2009-09-22" version="1">MESCDSELHLKLKSESTTNLRNNEVVGNFGNINYRFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X292</accession>
    <name>C6X292_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02118"/>
    <dbReference type="EnsemblBacteria" id="ACU08555">
        <property type="protein sequence ID" value="ACU08555"/>
        <property type="gene ID" value="FIC_02118"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02118"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_6_1_10"/>
    <dbReference type="OMA" id="GWTFHGH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="62"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="219"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="297"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="506" mass="57149" checksum="B68925B449D48D88" modified="2009-09-22" version="1">MGVYTYAHVIFLSTALSLSLPQITASFSEEAFCIMTINLTQNKHFKLFKLVSEVAAKNGQSAYIVGGYVRDLLMKRGVPSDIDFVTEGSGIDLAQALANEINPRWKVSVFKNYGTAMFKHNGLDLEFVGARKESYAEDSRNPAVEAGTLEDDQKRRDFTVNALAISLNKENFGELIDPFGGISDLKNKIIRTPLEPSQTYSDDPLRMLRAIRFASTLRFKIEENSLAAIKTEAERIKIVSRERIMVEFNKIMLSEKPSAGLKILEQTGLMQIILPELTALRGIEEVEGQTHKDNFWHTLEVVDNISKNTDSLWLRWAALLHDVGKAPTKKFVEGTGWTFHGHEFLGSKMVKTIFQRLKLPLGPDMKYVQKLVKLSSRPIALIDDGTSDSALRRLLFDAGEDLEDLFILNKADITTKNSFKQEKFKRNFETVALKIKEVEEKDQVRNFQPPITGEEIMELFSLKPGREIGVLKEKVKEAILEGEIQNNREDARLFVIAEAEKMGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A0</accession>
    <name>C6X2A0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02127"/>
    <dbReference type="EnsemblBacteria" id="ACU08563">
        <property type="protein sequence ID" value="ACU08563"/>
        <property type="gene ID" value="FIC_02127"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02127"/>
    <dbReference type="eggNOG" id="ENOG5033JVA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195072_0_0_10"/>
    <dbReference type="OMA" id="FYTRRIR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="70" mass="7475" checksum="49A8C9C2F949893B" modified="2009-09-22" version="1">MKLYNKIIFILFLGAGLFLRAEEPPLPPGGGGGVGPGAPASPVDMYVYVLAIVALALIAYYQRKVQKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G2</accession>
    <name>C6X2G2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase IV</fullName>
            <shortName evidence="12">Pol IV</shortName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dinB</name>
        <name evidence="15" type="ordered locus">FIC_02189</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02189"/>
    <dbReference type="EnsemblBacteria" id="ACU08625">
        <property type="protein sequence ID" value="ACU08625"/>
        <property type="gene ID" value="FIC_02189"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02189"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_10"/>
    <dbReference type="OMA" id="KVRRYDF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 12 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="14">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="12">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU08625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="360" mass="41382" checksum="6AD129F0D80ABA1D" modified="2009-09-22" version="1">MTENRKIIHVDMDAFYASVEQHDHPELRGKPVAVGGGQYGVVAAASYEARKFGVRSAMPGRLALEKCPHLIVVKPRFQRYKEISQQIRSIFNEYTDLVEPLSLDEAYLDVTENKKGIESANDIAREIRGRIYEETGLTASAGISVNKFLAKVASDYNKPNGQKTIHPTQILEFMEELPIEKFYGIGKVTANKMHEMHIFKGADLKNKSLEELIRLFGKSGNYYYNVVRGIHNSEVKPHRIQKSVAVEETFWDNLLDEEQVFAQLKTISEELEERLLKKEIKGKSITLKIKYKDFTQYTRSTTRDSYFGGAHDFFETARKLWELRPDDKPVRLLGLSLSNLNTQEKKQISVQLRIPFEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G3</accession>
    <name>C6X2G3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02190"/>
    <dbReference type="EnsemblBacteria" id="ACU08626">
        <property type="protein sequence ID" value="ACU08626"/>
        <property type="gene ID" value="FIC_02190"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02190"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972360_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="171"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="286" mass="33682" checksum="47AA228E50F4864A" modified="2009-09-22" version="1">MMMRLRDWGLSPLAEVHDEEKTINFSGYSILYSATEHIHLVIFDNEVYLKPETFYFIPPNSKIQLFGESRLAILIWFKVDLFVDRLEFLNHIKKGIFFRNPLGWAVPNNFMPFESIMKYYYLPTQEKLINKLFAKNLLINFLEFILIRTLMEHDPKMEDYRKDSVEKEIANNFVFILQKESTFNFTMEYYADKLNITKRTLDNAVQTMYGCTAKRFVIAKALEKAKKLLRGTEIPIKNISQDLGFSEESNFSNFFKKHTNSSPREFRDHAISQIPTLRIPGPEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J2</accession>
    <name>C6X2J2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyacyl-CoA dehydrogenase PaaC</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02220"/>
    <dbReference type="EnsemblBacteria" id="ACU08655">
        <property type="protein sequence ID" value="ACU08655"/>
        <property type="gene ID" value="FIC_02220"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02220"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_10"/>
    <dbReference type="OMA" id="KGVNYPK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="204"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="327"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="401" mass="45446" checksum="D82F5152A72E9D64" modified="2009-09-22" version="1">MQESRTKMGEESQISNLKSQISKVGIIGSGTMGIGIAHVAATSGCEVFLFDTNAEQTQKSLLNLEKTLDKLVDKQKISAEKSEEIFKNIKSCTELSDFKNCDLVIEAIIENKEIKTKVFQQLEQIVSEDCIISSNTSSISITSLSAELKKPERFIGIHFFNPAPLMPLVEVIPGLLTKENLAEGIFVLMESWGKIPVIAKDVPGFIVNRIARPFYGEALRMVEENIATPEQIDEAMRSVGNFKMGPFELMDLIGIDINFSVTKTVYQDYFYDPKYKPSLLQQRMTEAKLLGRKTGKGFYDYSDQSQEPRIKNQDLKNDKLYEEIFLRIISMLINEAVEAKRLGIAADEDLELAMQKGVNYPKGLLAWGKEIGYRKVSETLQNLYDVYQEERYRQSPLLRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P5</accession>
    <name>C6X2P5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPK2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02275"/>
    <dbReference type="EnsemblBacteria" id="ACU08708">
        <property type="protein sequence ID" value="ACU08708"/>
        <property type="gene ID" value="FIC_02275"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02275"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048699_1_0_10"/>
    <dbReference type="OMA" id="RTHYENV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="3">
        <location>
            <begin position="39"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="300" mass="34757" checksum="FEA4FBBC9D3B2335" modified="2009-09-22" version="1">MIFFIFNQNMKMDLNFSDNYFVQGKFSIAAAETEYSGQLQKAEGKEILETEKKKLRALQEKLYADGSKSLLIVLQAMDAAGKDSLIEHVFGGVNPQGCEVHSFKSPSSKEYAHDFLWRHYTALPEKGKIGIFNRSHYESVLVCKVHPEYNLNEKVWDSVSDFDEKFWKNRYDSIRNFEKHLADNGTKIVKIFLNVSKKEQKKRFLDRINEPEKNWKFAAGDLSETKLWDDYMKAYESAINETSKNHAPWYVIPADDKWFARVAAIQIIIEALEGMDLKFPKLSEAEQDGLEDAKKQLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V6</accession>
    <name>C6X2V6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807053.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02336"/>
    <dbReference type="EnsemblBacteria" id="ACU08769">
        <property type="protein sequence ID" value="ACU08769"/>
        <property type="gene ID" value="FIC_02336"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02336"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818005_0_0_10"/>
    <dbReference type="OMA" id="FNRPYYL"/>
    <dbReference type="OrthoDB" id="885466at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="338" mass="39725" checksum="0BC905103C3EA25B" modified="2009-09-22" version="1">MDILIKSFNRPFYLDRCIASIYSFVSGDFSVKILDDGTPEKYLHKIQTKYPDVVILKSDSYEEKSLAIAENLKVGSEIDGNKIPVSFWIAAVQKASDYFIITEDDVWFTEEINVDTLRTEVQKLNINLIKLGWLGNVKDDVYSDHFAISEHLDSLQPKNLLLGNRKIMKAFFFNDYKFFSLLYKLKLVDNETRNKYWLLNSILMGLYKKEYWLTIWQNMNGEVNEKMQLVNATVYYRKHRGNPNFISRLKNEAMKTTFQSSATNSYHQYGYGFDVNRFNHIINEAWLSGAFDAMENFPNDFSLDYFESFIKDEIPVAEFRKWVNHFKVQYRKLGADVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X0</accession>
    <name>C6X2X0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807067.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02350"/>
    <dbReference type="EnsemblBacteria" id="ACU08783">
        <property type="protein sequence ID" value="ACU08783"/>
        <property type="gene ID" value="FIC_02350"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02350"/>
    <dbReference type="eggNOG" id="ENOG5033Q4M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352955_0_0_10"/>
    <dbReference type="OrthoDB" id="1516949at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="22921" checksum="AAF234AEFA208FFF" modified="2009-09-22" version="1">MRKLTILFVLFSVFAFSQKRKKGLDVVSNIDVKVLAMKPIGNNSLAENLQPFYGFGFGGNLMTPINLGVGLDYSELFSNVQNGKQNLYGNLGSPRMTVIDAFLTHRENISDDFSVEEMAGASFYRHTNLYIDQTNQKKLNENAVGFHFGGKAIYTLHDRQQVFAAGKVNFYYGNVYNENPEIRNYYSRSVLLSLSLGYRYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X320</accession>
    <name>C6X320_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="2">2.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807117.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02400"/>
    <dbReference type="EnsemblBacteria" id="ACU08833">
        <property type="protein sequence ID" value="ACU08833"/>
        <property type="gene ID" value="FIC_02400"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02400"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075954_0_0_10"/>
    <dbReference type="OMA" id="NFEMETS"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="284" mass="32621" checksum="A08C223875D9DFD1" modified="2009-09-22" version="1">MLNKLAASELVLNPDGSVYHLNLLPEEIADKIIMVGDPDRVPKVSKYFDRVEIKKNKREFYTHTGTLRGERITVMSTGIGTENIDIVMNELDALVNIDLVNKEFKTEHKSLELFRLGTCGSVNPEVEVDNMLVTKNVVGLDGLLHFYQDYKFENDFSRNFMQNFPYEKIKPMLYFSDWAEDISDYYKDAKYHGNTATFPGFYAPQGRQLRLKALDDQFLETLNELGVTNFEMETSAIYGLSKLLGHKALTVNSVIANRRRGEFSADHQASEKNMIEWVLERIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X379</accession>
    <name>C6X379_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807176.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02459"/>
    <dbReference type="EnsemblBacteria" id="ACU08892">
        <property type="protein sequence ID" value="ACU08892"/>
        <property type="gene ID" value="FIC_02459"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02459"/>
    <dbReference type="eggNOG" id="ENOG502ZBVN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132521_0_0_10"/>
    <dbReference type="OMA" id="HHIEGRP"/>
    <dbReference type="OrthoDB" id="1905527at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009474">
        <property type="entry name" value="YphP/YqiW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40052">
        <property type="entry name" value="PTHR40052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06491">
        <property type="entry name" value="Disulph_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04191">
        <property type="entry name" value="YphP_YqiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="136" mass="14494" checksum="13E3B271548907D0" modified="2009-09-22" version="1">MYPEELVLPMKAELTDKGFEDLKTPEDVANAINKPGTTLVVVNSVCGCAAGAARPGVVFSLTGDKKPDNLVTVFAGFDKDAVAEARRFMAPFPPSSPSVALFKDGELVHMLERHHIEGNPAGAIAANLQSAYDEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X393</accession>
    <name>C6X393_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ordered locus">FIC_02473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807190.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02473"/>
    <dbReference type="EnsemblBacteria" id="ACU08906">
        <property type="protein sequence ID" value="ACU08906"/>
        <property type="gene ID" value="FIC_02473"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02473"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_2_0_10"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="297" mass="34151" checksum="5751A6D9F57C9899" modified="2009-09-22" version="1">MYHNPVLLTRSVDDLVTNPDGIYVDVTFGGGGHSAAILRKLSSKGRLFSFDQDLDALKNTIEDDRFTLINQNFRFLENSLMVYGIKGVDGVLADLGVSSHQFDAAERGFSTRSDAPLDMRMNVLQPLDAKKVINEYEEEQLADIFYYYGELREARKLAREIVHHRKLKPIETTEDLKKLFSYIPQFKQNKFFAQVFQAVRIEVNQELEVLKEMLVQSYNILKPNGRLVVISYHSLEDRLVKRYLKNGMFEGEPARDIYGNFQKTFELLQTKAVIPDATEIEENSRARSAKMRVGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B1</accession>
    <name>C6X3B1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02491"/>
    <dbReference type="EnsemblBacteria" id="ACU08924">
        <property type="protein sequence ID" value="ACU08924"/>
        <property type="gene ID" value="FIC_02491"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02491"/>
    <dbReference type="eggNOG" id="COG3530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176025_1_0_10"/>
    <dbReference type="OMA" id="MPFGKYE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024530">
        <property type="entry name" value="QSregVF_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40613">
        <property type="entry name" value="PTHR40613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12843">
        <property type="entry name" value="QSregVF_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="86" mass="10058" checksum="380022DBB7B27CCA" modified="2009-09-22" version="1">MEGLNPEILKEICTQKMPFGKYKDCVLADLPVNYLEWFYRQGFPKGKLGMQLSTIYEIKINGLVDLLKPLRGPVTYEKPKKKIYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C7</accession>
    <name>C6X3C7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.7" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807224.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02510"/>
    <dbReference type="EnsemblBacteria" id="ACU08940">
        <property type="protein sequence ID" value="ACU08940"/>
        <property type="gene ID" value="FIC_02510"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02510"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_10"/>
    <dbReference type="OMA" id="GVRTSWG"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="342" mass="38898" checksum="E5AA093F87DACFA6" modified="2009-09-22" version="1">MNYLVTGGSGFIGSHLVEHLLKNGHSVINVDNFDDFYDYRIKIKNTLSSTGLETAFAFQDKGRDIQKVIFETSSRDYQLYYQDIRDRSGLQKIFAKHKIDAVIHLAALAGVRPSIERPADYEEVNIKGTMNLWEVCREHRVNKIVCASSSSVYGNNEKIPFSETDSVDEPISPYAATKRAGEILGHVYHHLYGIDMVHLRFFTVFGPRQRPDLAIHKFTSLIRSKNEIPFYGDGSTARDYTYIDDIIDGILKTITYLHRNNGVYEILNLGENQVITLDEMLSAIEENLEIMSLKKRLPLQPGDVQITNADISKARALIGYNPTTNFHIGIKKFVEWFLRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C9</accession>
    <name>C6X3C9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="17" type="ordered locus">FIC_02512</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807226.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02512"/>
    <dbReference type="EnsemblBacteria" id="ACU08942">
        <property type="protein sequence ID" value="ACU08942"/>
        <property type="gene ID" value="FIC_02512"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02512"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_0_0_10"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0347">Helicase</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="5"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="179"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="615"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU08942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115851" checksum="53B2D59133FA0859" modified="2009-09-22" version="1">MGFIDKVLKGFLGDKNATDLKEVKKVVLKIKAVEPKIQELTDDGLRGKTAEFKEKIKTATATLSAQIEQTNEQIKNSANIDEKEELFNKIEQLKKDSYQIEEKVLNEILPEAFALLKETSRRLAQNGEIRVSATDLDKELAATKDFVALEGETAVWKNQWNAAGTPVVWDMVHYDVQFIGGVVLHSGKIAEMATGEGKTLVGTLPIYLNALTGRGVHVVTVNDYLAKRDSAWMGPLYQFHGLTIDCIDLHQPNSDARRKAYQSSITYGTNNEFGFDYLRDNMVTSPTELVQGELNFAIVDEVDSVLVDDARTPLIISGPVPQGDRQEFDVLKPSVDRIVEIQKKTVSGIFNEAKKLIANGNTKEGGFKLLQAYRGLPKSRPLIKFLSESGNKALLQKTEGQYMADNNKEMPKVDKDLYFVIDEKNNQIDLTDKGVEYMSAGNEDKDFFVLNDIATEIVELESKNLSKEEEFEAKEKLFSDFAVKSERVHTLSQLLKAYTLFEKDDEYVVIDGEVKIVDEQTGRIMEGRRYSDGLHQAIEAKENVKIEAATQTFATITLQNYFRMYNKLAGMTGTAETEASELWQIYKLDVVVIPTNKPIIRDDRQDLVFKTNREKYNAVIEEIERLTAAGRPVLVGTTSVEISQLLSRALQLRKIQHNVLNAKLHAKEAEIVAMAGGPGVVTIATNMAGRGTDIKLQGDVKANGGLAIIGTERHDSRRVDRQLRGRAGRQGDPGSSQFYVSLEDNLMRLFGSERIAKMMDRMGHKEGEVIQHGMISKSIERAQKKVEENNFGIRKRLLEYDDVMTKQRDVIYKRRKNALFGDHLKYDISNMIFDVSQSIVTKTKVDNNYKEFEFEIIKHFTMEAPVSEAEFKTKQIPELANILFNAATEDYRMKLELLKEKSFPIIENVFNTQGSMFKMIQVPFTDGIKTMTIVTDLKQAVETKCDSLINDFEKNISLAIIDENWKLHLREMDDLRRSSQGAVYEQKDPLVIYKQESFYLFSEMVEKVNREIVSFLYKGEIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F5</accession>
    <name>C6X3F5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08968">
        <property type="protein sequence ID" value="ACU08968"/>
        <property type="gene ID" value="FIC_02538"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02538"/>
    <dbReference type="HOGENOM" id="CLU_3373902_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="34" mass="3771" checksum="F5AD46B32E85B4CF" modified="2009-09-22" version="1">MNGALFLFSEKKKAGVEGGKRRPNNFNHSVSRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K6</accession>
    <name>C6X3K6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaA</name>
        <name evidence="13" type="ordered locus">FIC_00536</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00536"/>
    <dbReference type="EnsemblBacteria" id="ACU06994">
        <property type="protein sequence ID" value="ACU06994"/>
        <property type="gene ID" value="FIC_00536"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00536"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_1_10"/>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="185"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="12">
        <location>
            <begin position="396"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU06994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="488" mass="55459" checksum="2BC284907DD8F645" modified="2009-09-22" version="1">MENTMNENLPLIWERCLQFMRDNLSAAEDHTDLKKLENSFDLLFDNVRPVSLVSNNLTLLVPSDFYKEYIEDNYLSLLSAALKKNIGKGVKLWYQVMENKPAGQEAPITMNMKGKSIATPKMQETLPPSFSSNLINPFVVPGMKKINIDSNLKADFSFDNYVEGESNKFASTVARSIAKRPGATAFNPLFLYGGYGVGKTHLGHAVGLEVKNSYPDKVVLYLSSEKFIQQFVSAAKAHKQTEFANFYQMVDVLIIDDIQFLSGKKSTQDSFFHIFDYLHQNGKQIILTSDKAPVDILDIQDRIVSRFKWGLSAEIKSPDFDTRRKIIVDKLSRDGIVLTEDMLDFLASEVKTNVRELIGVINSVIAYSTVYKSELSLELLKETINKIAANQKKVINIPYIQEVVCEYFGIEREQLLSKTRKREIALPRQLAMYFAKEFTNATFTKIGEEMGGKDHSTVMYACDTIKDVSKIDKELKKYVKELTEKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N3</accession>
    <name>C6X3N3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782168.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00563"/>
    <dbReference type="EnsemblBacteria" id="ACU07021">
        <property type="protein sequence ID" value="ACU07021"/>
        <property type="gene ID" value="FIC_00563"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00563"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037251_0_0_10"/>
    <dbReference type="OrthoDB" id="1828178at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973534" evidence="1">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="268" mass="28976" checksum="9A826F3DB91E46ED" modified="2009-09-22" version="1">MKKTLLLGILVSMGVCRAQVGVGTNVNTFDDSEILRIVSANKGVLLPNVSIPDLHSAAPVSAPANSLIVYNTNNMTGKGFYYWQNSKWNPILDTTNIYKYLGIVRSESAVSTAGVNDASTISGVSYTLGEAPSAHDWQLIPGLAKTISIYSLQNTVSISGSGVAQVNTVSGGNTFMSYSIGLFVDSKLKSVRNFIITGKKNCLYNDFNVYFNVEMDTTGNHLIELRETLRVNQTSSQSITFGAKHASCSNLSPLMDKSIMNIQISERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R8</accession>
    <name>C6X3R8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ordered locus">FIC_00601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00601"/>
    <dbReference type="EnsemblBacteria" id="ACU07056">
        <property type="protein sequence ID" value="ACU07056"/>
        <property type="gene ID" value="FIC_00601"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00601"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053306_3_2_10"/>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="262" mass="29040" checksum="5B7B87FF4440DB4E" modified="2009-09-22" version="1">MHPENKHLMTFYKYHGTGNDFVMIDNRNLLFSKDKNLVSRLCDRRFGIGGDGLILLEEDAAADFRMVYYNSDGNESTMCGNGGRCIVAFAKFLDIFDVNTTFMAIDGLHEAEITNGTVKLKMIDVQSIEKDGECSVLNTGSPHFVQWVADLGNLDVRANGNKIRNSATYRNEGINVNFAEKISDSQIFVRTYERGVEDETFSCGTGATAAALDFLKNGNRNEVEVKVLGGNLKIYAKQNAGSFTDIWLEGPAEQVFTGEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3U7</accession>
    <name>C6X3U7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782231.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00630"/>
    <dbReference type="EnsemblBacteria" id="ACU07085">
        <property type="protein sequence ID" value="ACU07085"/>
        <property type="gene ID" value="FIC_00630"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00630"/>
    <dbReference type="HOGENOM" id="CLU_1989348_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="14834" checksum="21E488D26B60A2F9" modified="2009-09-22" version="1">MDKELNQINFRKQDKIILLFFFLFIFGLITLLGIFGYFKDDYRNQILNEQYSGKVIELFHDKSDHNNYKAKLSSGKIIYVYFPLETNFITLNVNDSIVKQKNSVYILLFKNGKFQQTINSLTKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3U9</accession>
    <name>C6X3U9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782233.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00632"/>
    <dbReference type="EnsemblBacteria" id="ACU07087">
        <property type="protein sequence ID" value="ACU07087"/>
        <property type="gene ID" value="FIC_00632"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00632"/>
    <dbReference type="eggNOG" id="ENOG50338CE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097479_1_0_10"/>
    <dbReference type="OMA" id="HPIVQYF"/>
    <dbReference type="OrthoDB" id="1392697at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="168" mass="19818" checksum="03A88B3CD20599A8" modified="2009-09-22" version="1">MRWTRIKKELENKLSPNLQGRLNYHITVYTKDYSASKSANRAWITFDKKEIVNISTEDFFKFNRYFYNKSTPTSCATSESEITERSEGNIIEKGEFSAYDFTECSYHFLNMNIEEALTHESPIINMFAVLDKRVGKRRLLKLTEKDLHPLVMNFLQLRIENEGFVTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X3</accession>
    <name>C6X3X3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00656"/>
    <dbReference type="EnsemblBacteria" id="ACU07111">
        <property type="protein sequence ID" value="ACU07111"/>
        <property type="gene ID" value="FIC_00656"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00656"/>
    <dbReference type="eggNOG" id="ENOG502ZSIN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568426_0_0_10"/>
    <dbReference type="OrthoDB" id="1895130at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973545" evidence="2">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="18762" checksum="C21A88DE4F319942" modified="2009-09-22" version="1">MKNLLKIIAVGGLVFTLASCGTANDAYGNNYPNYPQGNGGTYRTPDGNVYRQGEVYRDRNGNVYENGRVVRTGDVRSQPGILGRNGTILYPNRDARRLPPGQAKKIYGGSAKDYAPGQVKKRNSSYNNGTWRNDDIKKGKKNNDRKFTGKNDKNSKNLKGKNGKKAGMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y0</accession>
    <name>C6X3Y0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ordered locus">FIC_00663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782264.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00663"/>
    <dbReference type="EnsemblBacteria" id="ACU07118">
        <property type="protein sequence ID" value="ACU07118"/>
        <property type="gene ID" value="FIC_00663"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00663"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_1_10"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="435" mass="47872" checksum="554A80945BAE2067" modified="2009-09-22" version="1">MSGTFRIKGGQQLKGEITPQGAKNEALQILCAVLLTNEELRIKNIPDIHDVNRLIEILGDFGVKITKNGHGDYTFQADAVNFDYIKSADFKADGSKLRGSIMLLGPMLARFGEAYMPTPGGDKIGRRRLDTHFQGFVELGAEFFYDENEYLFSLKAKELRGKFILLEEASVTGTANIVMAAVLAKGTTSIYNAACEPYLQQLCKMLNRMGAKITGIGSNLLVIEGVTELHGTEHTMLPDMVEIGSWIGLAAMTKSEITIKNVNWNELGVIPNTFRKLGIYLEQRGDDIYIPAQENYKIQKFIDGSILTVSDAPWPGFTPDLLSIILVVATQAKGTVLVHQKMFESRLFFVDKLIDMGAQIILCDPHRATVVGLNHESPLRGTTMISPDIRAGNALLIAALSAEGNSTIHNIEQIDRGYENIDGRLRAIGANIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y9</accession>
    <name>C6X3Y9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UDP-2,3-diacylglucosamine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782273.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00672"/>
    <dbReference type="EnsemblBacteria" id="ACU07127">
        <property type="protein sequence ID" value="ACU07127"/>
        <property type="gene ID" value="FIC_00672"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00672"/>
    <dbReference type="eggNOG" id="COG2908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074586_1_0_10"/>
    <dbReference type="OMA" id="FDFWFEY"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010138">
        <property type="entry name" value="UDP-diacylglucosamine_Hdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990:SF1">
        <property type="entry name" value="PTHR34990:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="9">
        <location>
            <begin position="11"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="273" mass="32176" checksum="47B538A9D39DB383" modified="2009-09-22" version="1">MNKIDLHSGKKIYFASDQHFGAPNAKESKVREEKFIRWLNEIKADAQVLFLMGDLFDFWHEWNHVIPKGYVRVLGKLAELKDSGIELFMFVGNHDLWMKNYFEDEIGCKVFFDKQYFEINGQNFLLAHGDGLGPGDKGYKRMKKLFTNPLAQWAFKWLHPDIAMKVAIYFSTKNKMISGEEDKEFLGEDKEFLIIYSKEKLRTEKIDYFVYGHRHLPMVLDLKVNENKAKYVNLGDWISYFTYGVFEGSEFELNVFNHRDTEVITENTEESNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X415</accession>
    <name>C6X415_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kup system potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00698</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00698"/>
    <dbReference type="EnsemblBacteria" id="ACU07153">
        <property type="protein sequence ID" value="ACU07153"/>
        <property type="gene ID" value="FIC_00698"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00698"/>
    <dbReference type="eggNOG" id="COG3158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008142_4_1_10"/>
    <dbReference type="OMA" id="AADQFEI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="671" mass="75561" checksum="CB52D801D4E3412C" modified="2009-09-22" version="1">MRIKILLKMSESVQGNSHFDTKKLTAMGVLVSLGIVFGDIGTSPLYVMKAIVNARSDGSSMPFDEYIEGALSCIIWTLTLQTTLKYVIIALRADNKGEGGILSLYSLVKRLKKKWLYLIAILGAATLVADSVITPSLTVMSAVEGLKIYSPETPVVAITLVILALVFFIQQFGTSSIGKLFGPVMVVWFLVLGICGSLHIFDNLEILKSFNPYYAYNLITHSPSAIVIMGAVFLCTTGAEALYSDLGHCGKKNIRVSWVFVKSMLILNYLGQGAWLLHNHHLVAQGINPIFGIMPVWTILPGVILATAAAIIASQSVITGSFTMFSEAMSISFWPNQQIDYPSGVKGQMYIPRINWGLMVLCFIVVIYFKESEAMEAAYGLTITITMLMTTLLLFFWLRRTKVVSVFAFGFLVMYLFIELGFFYANVIKFFDGGWLTMVLGGFIAVCMYAWYNGRLIKAKFIKFVKLDKYVSIIKELKLDESIPKYSTNLAFLSRAKRPDEIEAKIIYSILRKQPKRADHYFILNISNQEDPFTFKYTIDEIMPGTIYRINFLLGFKIDRRINDYFDQVLADMMDEGSIPSRSSHPSLRAHNIPPDLKYVVIDNTYINDTLLTVKEKMTLNIYNFVKYIGSDDFKSWGVSPHNVVVESAPILDQQVVTKKIEQVYFNHYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X418</accession>
    <name>C6X418_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782302.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00701"/>
    <dbReference type="EnsemblBacteria" id="ACU07156">
        <property type="protein sequence ID" value="ACU07156"/>
        <property type="gene ID" value="FIC_00701"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00701"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_10"/>
    <dbReference type="OMA" id="PFMVPTY"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="392" mass="43488" checksum="81DDE6D016A7F1B4" modified="2009-09-22" version="1">MHSDFFKYQAQTTQFAAGFEVEKAEGSYIYGKDGRKYLDFVAGVSANTLGHSHPKIVEAIKTQAEKYLHVMVYGEYAQEMPVKLCKLLAEATPEPLEVTYLVNSGAEAIDGSLKLAKRYTGREEIISFKNSYHGNTHGALSVSGNEYHKREFRPLLPMVSFIEFNWVPDLEKITDKTSCVLLETIQGAAGFLVSENGYLKKLKSRCEEVGALLILDEIQPGFGRTGKLFAFEHYGIVPDILVMGKGMGGGVPVGAFMSSRKIMETLSHSPKLGHITTFGGNPLIAAASYATLKEVLESGLMNEVDEKEKLFRELLVHPKIKNINGRGLMLAVNLGSPEFTLNVAKRSMEKGLVVFWQLYKNEYLRISPPLTLSLDEIHEGCQIILQVLDETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X428</accession>
    <name>C6X428_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00711"/>
    <dbReference type="EnsemblBacteria" id="ACU07166">
        <property type="protein sequence ID" value="ACU07166"/>
        <property type="gene ID" value="FIC_00711"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00711"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104147_2_0_10"/>
    <dbReference type="OMA" id="FHITRSA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="154" mass="17442" checksum="8A33FC6FDD86A68D" modified="2009-09-22" version="1">MLLVGKQYHFETSTVINAPAEKVWQNMHSMKAFNQWNPFMELDPNIKVKYSGTSGNVGEQYCWEGNSEAGKGCHVITGLILNRKLSTKMLFKEPFESNATSDLILKPEGNTTKVTWTMDTELSYPMNLMSLFMDGEMEKSFGSGLRKLKTLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X447</accession>
    <name>C6X447_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic alpha-amylase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782331.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00730"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07185">
        <property type="protein sequence ID" value="ACU07185"/>
        <property type="gene ID" value="FIC_00730"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00730"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022115_0_1_10"/>
    <dbReference type="OMA" id="DKVMVVW"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972286" evidence="1">
        <location>
            <begin position="18"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="36"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="541" mass="60963" checksum="7A7CDF7320FF2221" modified="2009-09-22" version="1">MKKIFLLAGFAMLTSCATLQNNSKPNFTWEGANMYFLLTDRFANGDKNNDVNFGRTEKAAVLRGFEGGDLRGIIQKIDENYFTDLGINAIWMTPVVEQIHGATDEGTGDTYGFHGYWAKDWTALDPNFGTKADLKELVEKAHAKGIRIVLDAVVNHTGPVTATDPVYPASWVRTSPQCQYNNYQNTTACTLVANLPDVITESDAAAELPQMLVDKWRSEGRYETEMKSLDEFFARTGYPKAPKYYIMKWLADYVQEFGIDGYRVDTVKHTNEDVWKDFQLICQEAFDIYKTENPAKVLDNNLFFMVGEVYGYGISQKQDYNFGDKKVNYYQNGFKSLINFDFKGDANKTYDELFSDYSKLLHSDLNGKTVMNYLTSHDDGSPFDKDRKRTYESATKLLLAPGISQVYYGDETARDLTIEGTTGDATLRSNMNWSDVKYNPGTKKLLEHYQKLGKFRANHPAVGAGVHQVVSAAPYWFTRTYQNDVVLVGLDLNSGLKTVSVTGIFEGGTKVRDAYSGKTSKVENGRISFDTEFSIVLVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X468</accession>
    <name>C6X468_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome (Plasmid) partitioning protein ParB / Stage 0 sporulation protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782352.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00751"/>
    <dbReference type="EnsemblBacteria" id="ACU07206">
        <property type="protein sequence ID" value="ACU07206"/>
        <property type="gene ID" value="FIC_00751"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00751"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_10"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="40"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="295" mass="32873" checksum="D3386B922D0F4E1F" modified="2009-09-22" version="1">MRDKKRAMGRGLGAILSAESKASVNSATDAGADRFVGNIVQVPLEDIYPNASQPRTYFDEKGLQELAQSIKNLGIIQPITLRKDGGKFEIISGERRFRASKMAGLETVPAYIRLVNDQELLEMALVENIQREDLDAIEIALTYQRLLEEIGMTQENLSQRVGKERSSITNSIRLLRLNPEVQDAIRSGEISAGHGRAIISLEGSELQNELFQKILTNKLSVRQAEEESARLKNTANTEKKPKAALPNHFRKAEKNLADILDVKVEIKAAANGKKGKIVLDFKNEQELENILSHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A1</accession>
    <name>C6X4A1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipid A biosynthesis lauroyl acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782385.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00786"/>
    <dbReference type="EnsemblBacteria" id="ACU07239">
        <property type="protein sequence ID" value="ACU07239"/>
        <property type="gene ID" value="FIC_00786"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00786"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_4_1_10"/>
    <dbReference type="OMA" id="CEMKKVK"/>
    <dbReference type="OrthoDB" id="1106624at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="298" mass="35581" checksum="A7B294A0F87C8C86" modified="2009-09-22" version="1">MKFLFNIIVLFSRLPLWILYIFADLIFFLTYYIIGYRKAVVAENLRLSFPKKSAGELRKIQKAFYRNFADYIVETLKSFTISHLELRVRVQHLNQKIFHDAKAEQKNVILLAGHVFNWEWFSALATIVPQDHSYPVYRKVQSTFWEKGIKSIRDRFGNHALEAKEVIRHIFRNQNDGNSIYMFVADQTPHISEVSYGLEFLNQTTPAFIGYDKLATRMDLAFVFCEMKKVKRGFYQINYYRIDPDAEKFEENEVVRKFHKLLENTINKDPSNYLWSHRRWKYQHAVKVMDNHQTRANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C7</accession>
    <name>C6X4C7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gliding motility protein GldF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782411.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00812"/>
    <dbReference type="EnsemblBacteria" id="ACU07265">
        <property type="protein sequence ID" value="ACU07265"/>
        <property type="gene ID" value="FIC_00812"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00812"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081003_0_1_10"/>
    <dbReference type="OMA" id="MGLYAEE"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="242" mass="27203" checksum="25FED096225ADD52" modified="2009-09-22" version="1">MKAIFKKELWNYFGNWSAWLIIAAFSLIGTLFLFFFENDSNIFDIGTATLQSYFVLVPWLLMFVIPAVSMKTLAEEQQSGTLNWLFSQPLKISDIILGKFFAVWLVGILCLLPSLVYLYTVYALGVPQGNIDLGATFGSYLGLIILAAAFSAVGILASSLSQNQIMAYLLGVFMCFILYFGIEQLASYKLLGGADYWLSNLGFYQHFMAFTRGLIDTRDVFYFILIIALCLFFAKLSVAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E0</accession>
    <name>C6X4E0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ordered locus">FIC_00825</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00825"/>
    <dbReference type="EnsemblBacteria" id="ACU07278">
        <property type="protein sequence ID" value="ACU07278"/>
        <property type="gene ID" value="FIC_00825"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00825"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_0_0_10"/>
    <dbReference type="OMA" id="NMTAGHI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="382" mass="43158" checksum="DE376C370C89C6C9" modified="2009-09-22" version="1">MNSDYLSYFCKTLKRYIVMLKRVILLVGFFATFSVSLAQHATVAGEAHATEHVSDSEKVKAESQEFIQHHVKDAHSFDIMVTKDGHHIGFPLPVIFYDQDNGLHTMMSSAFNHGENTVESKGSHYKLFHEKIYKTDASGTIQMDDHGHATNAKMIDFSITKSVFAILLVSVLMLLLFISIARSYKNSLVPSGAGKIFEPLIIFIRDDIAKPNIGTNYKKYMGFLLTVFFFILFLNVLGLMPFGINVTGNIAITAALAIVTFLIVQFTANKTYWQHIFWMPGLPWPMKIVMMPIEIIGMFIKPFALLIRLFANMTAGHIVVMSLIAMIYVFKNVIAGIAFPFLTFVLYLLEILVAFLQAYIFTMLSAVYFGMANEEHHHEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4G9</accession>
    <name>C6X4G9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thrS</name>
        <name evidence="12" type="ordered locus">FIC_00854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782453.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00854"/>
    <dbReference type="EnsemblBacteria" id="ACU07307">
        <property type="protein sequence ID" value="ACU07307"/>
        <property type="gene ID" value="FIC_00854"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00854"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_10"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="240"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="639" mass="72451" checksum="33D0AC12D3791AF7" modified="2009-09-22" version="1">MIKITLPDGGIKEFESGVTPLDVAKSISEGLARNVISALVDGTQTEISSPITADSTLQLLTWNDDLGKKAFWHSSAHLLAQAIIEFYPEAKLTIGPAIENGFYYDVDFGDETLSEKDFENIEKKMLENAKKNSTFQLYPVSKADALKEYADNPYKTELISNLNDGEITFCSHDNFTDLCRGGHIPSTGIVKAVKILNAAGAYWRGDEKNRQLTRVYGISFPKQKDLTEYLERLEEAKRRDHRKLGKELGIFAFSEKVGAGLPLWLPKGAALRKKLENFLSEAQKKAGYEFVMTPHIGAKELYVTSGHWDKYGADSFQPIKTPNEGEEFMLKPMNCPHHCEIYKVGQWSYKDLPKRFAEFGTVYRYEQSGELHGLTRVRGFTQDDAHLFCTPDQLLTEFENVIDLTLYVFKSLGFEDFVTQISLRDPENKEKYIGSDENWKKAENAIIQAAAKKGLKTVVEYGEAAFYGPKLDFMVKDALGRSWQLGTIQVDYNLPERFDLWYIGSDNEKHRPVMIHRAPFGSMERFIAILLENTAGDFPLWLAPDQFTILPISEKYADYAKKVSELLENHDICGLIDDRNEKTGRKIRDAEIKKLPFMLVVGETEELNGTVSVRRRGEGDLGTMSVEDFIAYFKEQSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H6</accession>
    <name>C6X4H6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, short-chain specific</fullName>
            <ecNumber evidence="9">1.3.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00861"/>
    <dbReference type="EnsemblBacteria" id="ACU07314">
        <property type="protein sequence ID" value="ACU07314"/>
        <property type="gene ID" value="FIC_00861"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00861"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_10"/>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004085">
        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="136"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="242"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="393" mass="43282" checksum="D483D38A19BE4903" modified="2009-09-22" version="1">MRHFNYLWKQNKNMSLETMDNLNMIAETAKDFAEKNIRPNIMEWDESQHFPVELFHKLGEMGFMGIVIPEEYGGSGLGYHEYVTILDEISQVDPSIGLSLAAHNSLCTNHIYEFGNEEQRHRWLPQLASGKTLGAWGLTEHNTGSDSGGMNTTAVKDGDDWIINGAKNFITHAISGDIAVVMTRTGDKGAKNNSTAFVLEKGMAGFSSGRKENKLGMRASETAELIFDNIRVPDANRLGEVGSGFKQAMKILDGGRISIAALSLGIARGAYKAALKYSLERHQFGKPINQFQAINFMLADMATEIDASELLIQRASNLKNAKKPMTKEGAMAKLYASEACVRIANNAVQIFGGYGYTKDFPAEKYYRDAKLCTIGEGTSEIQKLVIGREISKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L8</accession>
    <name>C6X4L8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">META domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00904"/>
    <dbReference type="EnsemblBacteria" id="ACU07356">
        <property type="protein sequence ID" value="ACU07356"/>
        <property type="gene ID" value="FIC_00904"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00904"/>
    <dbReference type="eggNOG" id="COG3187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075808_3_3_10"/>
    <dbReference type="OMA" id="DIAMMRF"/>
    <dbReference type="OrthoDB" id="2029962at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="65"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="179" mass="20211" checksum="416F10D43252A4CE" modified="2009-09-22" version="1">MLRTGFSTDFARHRILTSEPGPIKILRCRSAKINHSIMNKLTLFLILIVSVFTVSCSTTMTGDKSKLAGKTWELEYITGPRITFEGLFPDRKPMISFAQETNMVTGNSGCNGYQTKYTLRGNMISFAEPELSTMMYCGDGETVFRKTMTQIDQYRIEADGKLVLMMGDTVMMRFKPAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M2</accession>
    <name>C6X4M2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KAP NTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782506.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00908"/>
    <dbReference type="EnsemblBacteria" id="ACU07360">
        <property type="protein sequence ID" value="ACU07360"/>
        <property type="gene ID" value="FIC_00908"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00908"/>
    <dbReference type="eggNOG" id="COG4928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523558_0_0_10"/>
    <dbReference type="OrthoDB" id="1358927at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KAP NTPase" evidence="1">
        <location>
            <begin position="173"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="506" mass="59530" checksum="6FCB11AD0225534A" modified="2009-09-22" version="1">MDNTTLKLDNAPLFTDFDNHISIEQNDRILFSAPFGTGKSTYLNEYFEDRSDSYFCFNLYPVNYSVSPNEDVFELIKFDLLLQLLANYKQEIDLQNQEFSNVLSFQALFIKEFKLTPLLLSLIGESGKVGKSAKILIDEVKKQYLQFKDSFNDEENFLESYLANIESKIGNVNEMDAYSSMITTLLTRVQLKNEKKQSVLIIDDLDRLDPEHIFRLFNIFSVNFGKDDILNKFGFKKIIFVCDIENIEGIYKHKYGVNVDFTGYIDKFYSSTPFQFDNKKIIKLRIEDILSNYLINGEIYFHEKKGVRYQEFVALKSLMMYFLEYKLINLRMILENKNIDIPVKTITYNSNQTYYYKFPLLVLFALLSRIVGGYRNLQEILVKILAREYTREISTDHKDPKLYMDNKRATDNLINLCLPFLIEYDVQGKIVNKANIEGQNNDAIFVQTFECYIHYKTEYNYDRDVEIFNVLKITESPSIDSKERTINPIELFDYAYKFCDSKNFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M6</accession>
    <name>C6X4M6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07364">
        <property type="protein sequence ID" value="ACU07364"/>
        <property type="gene ID" value="FIC_00912"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00912"/>
    <dbReference type="eggNOG" id="COG1808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902399_0_0_10"/>
    <dbReference type="OMA" id="VIMSAYR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="308" mass="33773" checksum="5F6DF80582392171" modified="2009-09-22" version="1">MHRTIEASIPKTCTPAVTKALLDNPHVIHLSVHPDSSLKPLGDTLVIHVLNRGTDDVLKMIGKETEGKEFSIATAEVASLTHDSKQKEINHDVDEAIWEEMETGLRHNGRTTTNYLILMFIGGVIASVGFISEMHDLVIAFVAASIIAPGMEPLAKIPLGIALKKWDVMWTGLKATFLGYFTLVAAALLTFAVLVNFGLAKEEDFTHNQATAGMLHLRLKDIILSLAAATASIIMYLSYRTNVIAGPLIALIIIPAAAAMGISLYLQNWEFLGNFSKRFLLDVTTIIIVGIICILLKQKFVHKREPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P8</accession>
    <name>C6X4P8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_00935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for cell division and gliding motility.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782532.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00935"/>
    <dbReference type="EnsemblBacteria" id="ACU07386">
        <property type="protein sequence ID" value="ACU07386"/>
        <property type="gene ID" value="FIC_00935"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00935"/>
    <dbReference type="eggNOG" id="COG2177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073546_3_0_10"/>
    <dbReference type="OMA" id="ETGIMRL"/>
    <dbReference type="OrthoDB" id="1653234at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="12">
        <location>
            <begin position="54"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="11">
        <location>
            <begin position="204"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="299" mass="33704" checksum="632C3B551C2B0932" modified="2009-09-22" version="1">MAKTAEDFNKRRLRSSNITVVVSIALVLFLLGLMGLILINAQKYSDYIKEQLVVNAYFDENFDAKDSAKTVKMEAETFKKIQALGPVKRATYISREMAAVEAKKSMGIESSALFEENIFPSSVEVALKPEFVDPAKIDEAIKQIKSTPGIVDVKNNSTLMVEVYNNLNNILKWILGFSVLFLILAVVLINNSIRLKIFSKRFIIKTMQLVGAKRRFILKPFIKEAVILGVIGALLGLAVLFGAWYYFITQIGTPFVQDNNQLLILVISIFLLGVFITVFSTIFATWRFLRSNVDDLYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U9</accession>
    <name>C6X4U9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00986"/>
    <dbReference type="EnsemblBacteria" id="ACU07437">
        <property type="protein sequence ID" value="ACU07437"/>
        <property type="gene ID" value="FIC_00986"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00986"/>
    <dbReference type="eggNOG" id="ENOG502ZBVZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902131_0_0_10"/>
    <dbReference type="OMA" id="QWFPIFG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973694" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="236"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="306" mass="34341" checksum="A9259197D103B427" modified="2009-09-22" version="1">MKHMYFLAAALFCSTISAQSVISFESSEGYVLGDINSQNGWTVTETSDGPLTNQIVTDEVSSTGNFSFKNAYVPEYGDQWFPIFGIEKSFPTALDYRNTTISYDFMAPEQDGADFEFALYSINEEEEVFDILLAVGFENRGYIYIYPEMNFGGFTYANASWDANQWYNLKIEIKENTITYYLDDVEIYTGPNTSKVNVNGMNILHNNYGGSAYYDNFKIETSNLSVADVPGRNIKIYPNPVVDYVTIELPAGEKLNTVDVYYLTGQKVTGFKADTKLDLSKLHSGAYILKATSAQGKTYSSKIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V6</accession>
    <name>C6X4V6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative stomatin/prohibitin-family membrane protease subunit YbbK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782590.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00993"/>
    <dbReference type="EnsemblBacteria" id="ACU07444">
        <property type="protein sequence ID" value="ACU07444"/>
        <property type="gene ID" value="FIC_00993"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00993"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_5_0_10"/>
    <dbReference type="OMA" id="TQIRAEM"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="310" mass="34430" checksum="882F66BCA54516F0" modified="2009-09-22" version="1">MAYLGIIIFLGLVVLFASFFTVKQATAAIVERLGKFHVVRQSGLHLKIPFIDQVAKRMNLRIQQLDVIIDTKTLDNVFIRMKVSVQYQVITAQVADSFYRLENPENQITSYVFDVVRAEVPKLKLDDVFVRKDDVAIAVKGELQEAMQSYGYDIIKALVTDIDPDEQVKHAMNRINAAEREKTAAEYESEAQKIRIVAVAKAEAESKKLQGMGIADQRREIAKGLEESVKMLNEAGISSQEASALIVVTQHYDTLHSIGANNRSNLVLLPNSPSAASSMLNDLVVSMAATQKMEESTKGDYPPPSGKHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X3</accession>
    <name>C6X4X3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782607.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01011"/>
    <dbReference type="EnsemblBacteria" id="ACU07461">
        <property type="protein sequence ID" value="ACU07461"/>
        <property type="gene ID" value="FIC_01011"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01011"/>
    <dbReference type="eggNOG" id="ENOG5032Z4I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193614_0_0_10"/>
    <dbReference type="OMA" id="GIFGWYS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="75" mass="8366" checksum="B41D51CC57AFE97C" modified="2009-09-22" version="1">MDSVKKILGIVWLLLALVVAYYGLSVFGIPKIMSDKQEDNVFGWIILVILVPIIVGGLGIFGWYSFKGEYSDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X6</accession>
    <name>C6X4X6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01014"/>
    <dbReference type="EnsemblBacteria" id="ACU07464">
        <property type="protein sequence ID" value="ACU07464"/>
        <property type="gene ID" value="FIC_01014"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01014"/>
    <dbReference type="eggNOG" id="COG3677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076276_1_0_10"/>
    <dbReference type="OMA" id="LIKWERF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="20159" checksum="F4AA1BEC4D20F528" modified="2009-09-22" version="1">MILQKSGLIYSILRNQWNDANLIYICYKSIHMSNTCPKCQQQNVVKSGIVKERQRFLCRSCNYYFTVKKLGKQIDDYYVTKALQLYLEGLSYREIERILGVSHVTISSWVRKYNIKRPPHTEFHTTYKVFKQAELIDYMKVEDNIKGSGLIITEFGDKFMMIKWERFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z4</accession>
    <name>C6X4Z4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782628.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01032"/>
    <dbReference type="EnsemblBacteria" id="ACU07482">
        <property type="protein sequence ID" value="ACU07482"/>
        <property type="gene ID" value="FIC_01032"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01032"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147365_1_0_10"/>
    <dbReference type="OMA" id="VNPIEKW"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="133" mass="15713" checksum="CD8F8DB5759AEEB0" modified="2009-09-22" version="1">MEQKIHQGRNVKRFREMLGIKQEALAFDLGDDWNQKKISLLEQKDVIEDPMLKKISEVLKIPVEAFQNFDEEQAVNIISNTFNDQSNGYNYYPTFNVNPIEKWIEALEEIKRLNAELLKSKDEQIKLMEKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X503</accession>
    <name>C6X503_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01041"/>
    <dbReference type="EnsemblBacteria" id="ACU07491">
        <property type="protein sequence ID" value="ACU07491"/>
        <property type="gene ID" value="FIC_01041"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01041"/>
    <dbReference type="HOGENOM" id="CLU_215292_1_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="53" mass="6206" checksum="6CBDFB45C08EF49D" modified="2009-09-22" version="1">MGNQQPQTDRKSKMKMWFKRVGIGGLIFFTVKGIAWLFVFYYGAEIFRNCAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X512</accession>
    <name>C6X512_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805785.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01050"/>
    <dbReference type="MEROPS" id="S09.A77"/>
    <dbReference type="EnsemblBacteria" id="ACU07500">
        <property type="protein sequence ID" value="ACU07500"/>
        <property type="gene ID" value="FIC_01050"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01050"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_3_2_10"/>
    <dbReference type="OMA" id="KHRWGGW"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="3">
        <location>
            <begin position="108"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="442"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="647" mass="73465" checksum="5BB41D18980FE8D0" modified="2009-09-22" version="1">MNYKYIFPVLLFSGSMMFSQSKTEVIVPNENLIVQNIPAIPKSLNEKIKKYSESRSANFTAIHPNGKELIMVTRFASTNQLHKLSSAMGNRKQLTFFDEPVNSASYEPTKGEYLVYSKDIGGNEFGQLFRLDLKTMESTLLTDGGRSQNGGVTWLKDGSGFYFSSTKRNGGDRDIYFMNPLKPAETKLVLQLKSGGWGINDISDDGKKLIIGEYVSANESHLYLFDTQTQKLESITDRKEKQIVQGSAKFSKNADEIWYVTDRDNEFDRLATLNLKTKKRNYFTSDIPWEVSDYTLSEDKSKIVFQTNESGLHKLYLMDTASNKYSEIKGLAVGLVNNFEFTNDGRSLFFSQSTYDSSADIYRLDLASNTIERWTDSEQGEMQKADMSEPKLIEWNSFDQMKITGFYYPASKKFTGKRPVLINIHGGPEGQSMASSLGSGNYYTNEMGVALIYPNVRGSSGFGKTYIASDNGFNRMNSVKDIGALLDWVAKQPELDKDRIMIMGGSYGGFMTLAVAYEYADKIRCSVDIVGISDFNTFLKNTEEYRRDLRRVEYGDERDPKMSAFFTKIAPLNNTDKIKKPMFIIQGTNDPRVPVTEAIQMRDKLKAQGNTVWYLEAKNEGHGFRKKENVDFQRLAVIQFMQEYLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X585</accession>
    <name>C6X585_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="12" type="ordered locus">FIC_01123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01123"/>
    <dbReference type="EnsemblBacteria" id="ACU07573">
        <property type="protein sequence ID" value="ACU07573"/>
        <property type="gene ID" value="FIC_01123"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01123"/>
    <dbReference type="eggNOG" id="COG2156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077094_1_0_10"/>
    <dbReference type="OMA" id="KYFWPRP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="211" mass="23069" checksum="A0E7A02C238A085B" modified="2009-09-22" version="1">MLLFRLSGLKSSISLSLYLFKKLPTMKKHILPAVKLTAVILIFFAVLYPLTVWGIAQLVPNNGKGDIIQHQGKKYYTNIGQSFTQDNYFSSRPSAVDYNAAGSGGSNKGPSNEEYLAEVQARIDTLLIMNPGMTKADIPVDMVTASGSGLDPHISVQAAKFQVKRIAKTRGIDPGKVEQLIVDHTDQPLMGLFGPEKINVLKLNIALDQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E5</accession>
    <name>C6X5E5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of hypothetical function DUF72</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805918.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01183"/>
    <dbReference type="EnsemblBacteria" id="ACU07633">
        <property type="protein sequence ID" value="ACU07633"/>
        <property type="gene ID" value="FIC_01183"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01183"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_3_1_10"/>
    <dbReference type="OMA" id="YLRMHGR"/>
    <dbReference type="OrthoDB" id="1068600at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="242" mass="28441" checksum="36E73D565D50DA1A" modified="2009-09-22" version="1">MKNKVYIGCSGFSGRDLKGFFYPEDLPSKEQLTYYSSKFSAVEINSTFYRKPRRQTLQNWYNLTSSDFRFFIKIPKSITHIQKLEEVKTTVSEFCRYIETDLIEKLAGFLFQLPPSFHFSEENLKKVLETVDPAFLNVVEFRHASWWRDDVFETLKNHNIIFSGVSYPKNISDDFITNHPNAAYYRLHGVPVMFKSEYSEEEMDELATQISNTDREVYVFFNNTWGTSALKNALYLKKILKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E8</accession>
    <name>C6X5E8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lead, cadmium, zinc and mercury transporting ATPase</fullName>
            <ecNumber evidence="8">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="8"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_013062.1"/>
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        <property type="gene ID" value="FIC_01186"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="7">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACU07636.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="840" mass="91487" checksum="8B5F6F0EE68AC4BE" modified="2009-09-22" version="1">MEKHHHNHPHTPPSERISPSSVYYCPMECEGEKVYFAPGKRCPVCNMFLVPIEERDDYKNKTATYSKTNLPQSFAEKIGEYFCPMFCEGDKTYDSDTGCPVCHMHLEQIDEKLLMGNKQSAMGSSTHHPLPITNDNAGKYYCPMFCEGDKVYDSNVGCPVCGMDLVQIPGKGEVIEDNTFNILKKKSLTALVFTVPVFVLSMGGMFIDFPFSHRIQGILEFVLTLPVVFYSGWFIMKRGWVSFRTWNLNMFSLIALGVLAAFLFSIVALLFPGIFPHEMGHDKAPLYFEAICVILTLVILGQLMEAAAHKRTGNAIKELMNLSPDEANLIVDGIENKVPLAQIKVGDVLRVKPGEKVPVDGLITDGSSSIDESMITGEPIPVEKQANDKVTSGTINGNGSFLMKTEKVGDETLLANIIKMVHDASRSKAPIQTLVDKVSRIFVPTVIVISVLTFIAWYIFGGEDRLILAFVNAVAVLIVACPCALGLATPMSLMVGIGKGARNGILIKNAEALEQMAKVNVLITDKTGTLTEGKPSLDTIAGIEEGNENLILKLAAALNQNSEHPLANAVLHAFKKEHSTLETVEEFENISGKGIKGSINSARILLGNEALLHEFKISVPARLKQKGTAQQDLAKTVSYISKDDEVLGFLAFSDKIKPSSKNAINYLHRNNVEVIMMTGDNAHTAKAVSNELGIKKFHAEQLPQDKLEMIKSLQQSGNIVAMTGDGINDAPALAQAEVGISMGTGSDVAIESSEITLLKGDLLGVAKAQILSAKLLKNIRQNLFFAFFYNILGIPLAAGLLYPFFGILLSPMIAAAAMSFSSVSVILNSLRLNSVDLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G5</accession>
    <name>C6X5G5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01205"/>
    <dbReference type="EnsemblBacteria" id="ACU07653">
        <property type="protein sequence ID" value="ACU07653"/>
        <property type="gene ID" value="FIC_01205"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01205"/>
    <dbReference type="HOGENOM" id="CLU_1370406_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="199" mass="23656" checksum="39AD094167C2AA41" modified="2009-09-22" version="1">MSLCIFTKTSYHNPRQRKHPTVIGILMTTIDTKRHIEINEGYQGINLTEFAIGVDELISNDQIVDTFIRSKKFSFDSLRDCVKAEPDKGYLRQAFDVDKIKITDFKKTDKQGVSKFLINFLNEPDWGDDKNEFAKLLDRYFEIHKEFGDNEFYILSKDWFDKEDERVIEPESWVYTYYFLIISVERKANLLTLTEWTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G8</accession>
    <name>C6X5G8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07656">
        <property type="protein sequence ID" value="ACU07656"/>
        <property type="gene ID" value="FIC_01208"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01208"/>
    <dbReference type="eggNOG" id="ENOG5033XAI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233923_0_0_10"/>
    <dbReference type="OMA" id="DHIANKI"/>
    <dbReference type="OrthoDB" id="1533280at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="244" mass="28158" checksum="AA821BA57D1ECFCF" modified="2009-09-22" version="1">MTDYELKNIDPDDINDLLVKVEKSFNIKFGDTELMHISSFGELCDHIANKIQLDNSDDCTSQQAFYKIRDAISSTLQIDNKTISTDFALVDLLPRQSRRSRTKKLEKHLGIKLNILRPPHWMTVTLVIIFLASLIGLYFMWQIGLSGLLFSIGGLWLANKIGSELDLQTVGQVAEKMTRENYLKSRRNPRTFNKNEIEKVLTEWFSEEFDLDKNKLSREAKFVRQKEKALLVITKLSSCPQDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H3</accession>
    <name>C6X5H3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01213"/>
    <dbReference type="EnsemblBacteria" id="ACU07661">
        <property type="protein sequence ID" value="ACU07661"/>
        <property type="gene ID" value="FIC_01213"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01213"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_5_10"/>
    <dbReference type="OMA" id="KTYRIYF"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="253" mass="29463" checksum="C9E650524B95BEB2" modified="2009-09-22" version="1">MAALALHFKTLPTELDPEQVKDYLFELQQRSKTPSQSYFKHTVYGLRFLLKTEGLPYSFLHLPAIPQVKKLPVILSREEIWRMLQSAELLKHKLLIGLIYGCGLRCMEVRNIELQHLDFDRKMLHIVQGKGSKDRYVPLSEHLIRGLKTFISIENPNQYLFNGNQNRNIEDIDVLAPNRKDFDSRYSQRGVQWVIKTISKKAGITKEVHTHTLRHSYATHLLEDGVPIIMVQKLLGHERIESTMEYLHSLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I0</accession>
    <name>C6X5I0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805953.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01220"/>
    <dbReference type="EnsemblBacteria" id="ACU07668">
        <property type="protein sequence ID" value="ACU07668"/>
        <property type="gene ID" value="FIC_01220"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01220"/>
    <dbReference type="eggNOG" id="ENOG5033HQS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1719653_0_0_10"/>
    <dbReference type="OMA" id="DHEDWKE"/>
    <dbReference type="OrthoDB" id="2174469at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="152" mass="18617" checksum="35F46B2B407FF909" modified="2009-09-22" version="1">MTRIIFLTFLFFTIINVAGQNFNVILQVNDQNINGQIANIYLSNNSQKNDERISVNYYPGDLIIPDYEKLNFENLNEKFYLNFDYYTYKKEMPEIKRFKIELTKKILKNPYLIINIYDFRNRKYKKWFQYLTKEDYLVQLTYPNSGLWIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q1</accession>
    <name>C6X5Q1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806024.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07739">
        <property type="protein sequence ID" value="ACU07739"/>
        <property type="gene ID" value="FIC_01291"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01291"/>
    <dbReference type="eggNOG" id="COG2315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105851_1_1_10"/>
    <dbReference type="OMA" id="NKRHWNT"/>
    <dbReference type="OrthoDB" id="1817663at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="13433" checksum="DAC0093B8715B5DD" modified="2009-09-22" version="1">MEISEIHQYCLSKKGVQETFPFDNETLVMKVGGKMFLLMSLDTQPVSISVKTDPEWSAELREQHPQITGAYHMNKTHWNSVVCKGLKQDLILKLIDHSYDLILNSLTKKIKEEVLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q5</accession>
    <name>C6X5Q5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806028.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01295"/>
    <dbReference type="EnsemblBacteria" id="ACU07743">
        <property type="protein sequence ID" value="ACU07743"/>
        <property type="gene ID" value="FIC_01295"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01295"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018720_0_0_10"/>
    <dbReference type="OMA" id="SDGRWNK"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="340"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="728" mass="83710" checksum="FD5890F514C10A79" modified="2009-09-22" version="1">MKDLLLITPPFTQLNTPYPATAYIKGFLNTKGIGCFQMDLGIEVIIELFSKTGIENVFSQGIDLATASENSKRIFALRGEYIRTVDQVILFLQNRNATLARQICSMNFLPEASRFNQLEELDYAFGNMGLQDKAKHLATLYLEDISDYIVENIDADFGFSRYAERIGQSANSFDDLYHKLCGKQSYIDEITLRILQNRIDQVQPQMVCFSVPFPGNLYSAFRCAKFVKENYPHVKVAMGGGFPNTELREVKDPRVFEFFDFITLDDGELPIELLTDHLKSNSDNSFKRTFLLENGEVVYKNNSTRADYKQAEVGTPDYSDLLLDQYISVIEIANPMHSLWSDGRWNKLTMAHGCYWGKCTFCDISLDYIKIYEPVAARILVDRMEELIRTTGESGFHFVDEAAPPALMREVALEILRRKLVVTWWTNIRFEKSFSRDLCYLLKISGCVAVSGGLEVASDRLLKLIDKGVSVEQVAQVTRNFTEAGIMVHAYLMYGFPTQTVQETVDSLEMVRQLFEMGVLQSGFWHQFALTAHSPIGQNPEEFGVIPLRQDIMFANNDIDFRDEIGTDHSVFSFGLKKSLFNYMHGINFDLPLSDWFDFQIPATSIDPDYIHDCLLEHEDFKFKENSKIVFLTGNALAQDYVRTKKGNSWEITQLTFHLNTNILKIELDRDKAHWLMKTIEENSVMNLKKTTLQQLKMSFEEKWYDFELFWFSKPMQQLKENGVVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R3</accession>
    <name>C6X5R3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-deoxy-8-phosphooctulonate synthase</fullName>
            <ecNumber evidence="6">2.5.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57693"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="EC" id="2.5.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the KdsA family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.55" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806036.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01303"/>
    <dbReference type="EnsemblBacteria" id="ACU07751">
        <property type="protein sequence ID" value="ACU07751"/>
        <property type="gene ID" value="FIC_01303"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01303"/>
    <dbReference type="eggNOG" id="COG2877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036666_0_0_10"/>
    <dbReference type="OMA" id="FRGIPTM"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00357">
        <property type="reaction ID" value="UER00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008676">
        <property type="term" value="F:3-deoxy-8-phosphooctulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006269">
        <property type="entry name" value="KDO8P_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21057">
        <property type="entry name" value="PTHR21057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01362">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="7">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="269" mass="29693" checksum="EA47C40C8ECC8636" modified="2009-09-22" version="1">MIQHLDNIHHKNSSNFFLIAGPCIIEGEDMALRIAEKVLEITNRYQIPYIFKGSFKKANRSRVDSFTTIGEEKSLEILKKVGETFNIPTTTDIHENEHAALAANYVDVLQIPAFLVRQTDLLIAAAKTGKCITLKKGQFLSPESMKFAVEKVTDSGNEKTAIIERGNSFGYTDLVVDFRGIPTMRNYAPVILDVTHSLQQPNQNSGVTGGRPELIETIAKAGIAVGADGLFIETHPDPSCALSDGANMLRLDKLEDLLQKLTRVRQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S8</accession>
    <name>C6X5S8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806051.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01318"/>
    <dbReference type="EnsemblBacteria" id="ACU07766">
        <property type="protein sequence ID" value="ACU07766"/>
        <property type="gene ID" value="FIC_01318"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01318"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OMA" id="WRGVRTD"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="859"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="2">
        <location>
            <begin position="393"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1051" mass="115312" checksum="ACE14E08AB819CC8" modified="2009-09-22" version="1">MKIVEIAIKRPSVVIVMLALLIIGGIFSYTQLNYELIPKFEVKVVTVSTIYPGASPSEVESTVSRKVEDAISSLEGIKKIQSKSYESLSVVIIQFNNDADVDFALNEAQRKINAIRSELPEDIEEPSLSQFSISDAPIISMGVTANLTQSELYDLIDQKIQPEFSRIQGVAQVNIVGGQEREIRVNLDQNKLEGYGLTIPQVQQIISTSNLDFPTGSLKTRQNSTLLRLSGKIQTVDELRNLTISSVNGQNIKLSDVAEVQDTQKETDKIARIDQQSTILLQVQKQTDANAVEVSELVRQKVEQMQLQYKAENLNVNIANDTSLFTLEAANSVIKDLFIAVGLVAFVMLFFLHSFRNALIVMVAIPTSLVATFIGLSLLDYSLNLMSLLGLSLVVGILVDDAIVVIENIHRHMEMGKNKVRAAYDGASEIGFTVTAITLVIVVVFLPIAISSGLVSDIIRQFCVTVIIATMLSLVVSFTVVPWLYSRYGKLDLISKDSLFGKVIYKFEAGLTRFTEFITGILTWSLGHKIKTFAITFALFVSAILMVAFGYIGSDFFPGTDKGEFLVQIEMPKDVSIEQTNFMTQKAEAFLAKRPEIERMITTVGQASTGMGGAQATGYQSEISVKLIEKTGKSETSKVYAAKIKRELEKELVGAKITTVPIGFMGAEQAPLQMTVVGSTLEEVMAYAKQAEAQLKTIDGASEVELSVEEGNPEISVTVDRDKMASLGLNVATVGQTLRTAFSGNDTNKFRTGNNEYDINIILDEAYRKSIDDVRNINFKNADGMSVQLSQFATITNASGPSLLERYDRSPSVTVQSQVVGKTTGTIAAEWETKMADVKKPAGVSWIWGGNMENQSEGFGTLGVALLAAIMLVYMIMVVLYNDFVKPFIVLFSIPLSFIGALWALALTNQSLNIFTILGVIMLIGLVAKNAILLVDFTNHRIDKGETIENALIQANHARLRPILMTTIAMVFGMLPIALASGAAAEMNNGLAIVIIGGLLSSLFLTLIIVPVVYYIVVKLEKKFSKDEKTDYDQEMKADYEHLHPDQELDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T8</accession>
    <name>C6X5T8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01328"/>
    <dbReference type="EnsemblBacteria" id="ACU07776">
        <property type="protein sequence ID" value="ACU07776"/>
        <property type="gene ID" value="FIC_01328"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01328"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_106_2_10"/>
    <dbReference type="OMA" id="EMHDSIG"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973631" evidence="4">
        <location>
            <begin position="36"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="5">
        <location>
            <begin position="414"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="614" mass="70098" checksum="1DA392AFD0910270" modified="2009-09-22" version="1">MYTCPEKYNLGLNKHKLKFRIFIVCLFLLAPFCSAQMLQDSVTKQINSAENAQEKLKLYRKYAELFSTKDFSRSIVLAHEGRKLARKLKNTTLEGDFLRLKGNAHYISGKLDSAGSYYYRALSLLKDQNQPKYLAELYNNLGRFYRKTKDFPRALKNYDLALNLYRQLNDTEGIATIYNESGVVYEYLGQHEDAVRRYSQSLEMQKKRGDLVGQGYALEFIGGSYLLQKKYVQAEKYLRQSLQLRQKTNDQFALAMNYNVLGHLYMAQNKYSEAEKNFQISNEISGRLNYLDLQKDNFENLAKIYRIHGDNDAAYESLNKFRIINDSIFSLGKARQIEELSLKYETAEKDRQLLAEKSKVLKRNVLAFSLFGLLLLGFFYYKIYQHKQKITLQREILHQQNLATIAVINTEDNERKRMATHLHDGIGQLLAAANMNISVLDEYKSDENAFEKILVRTRSILAEAIADARTLSHQIMPNILIKNSLPTALQDLVDKTGSPKLQIDLQLAGLKNNLNQNIQVVLYRTIQECLNNTIKHARATKVSIVVEQTQDSVIAHYADDGVGFDLTAEDGKNSLGLSNIGSRIEILRGTFLLETAPGAGVSLTLTIPLETYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V8</accession>
    <name>C6X5V8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium voltage-gated channel subfamily KQT possible potassium channel, VIC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_01348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01348"/>
    <dbReference type="EnsemblBacteria" id="ACU07796">
        <property type="protein sequence ID" value="ACU07796"/>
        <property type="gene ID" value="FIC_01348"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01348"/>
    <dbReference type="eggNOG" id="COG2126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011722_1_3_10"/>
    <dbReference type="OMA" id="KGIYWAI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="12">
        <location>
            <begin position="36"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="280" mass="32568" checksum="6F5411B048280FA1" modified="2009-09-22" version="1">MIKPFMEKEHNFISEKTRWKRKVFRIIFKADTRLGKLFDLILLTLILLSTFIVMMESVKIYDAKLHHLFVVLEIIITAFFTVEYVLRIITIRNKKAYIFSFFGIIDFLSILPFYLSLFFPITKYFLIIRMLRMLRIFRILNLLDFMHDGYFIVRALKNSSRKIYIFLLFLVIFSVIVGSLMFMVEGHRPGFESIPQSIYWAVVTVTTVGYGDVSPGTPLGKFLSVLLMLAGYSIIAVPTGIVTAEMRNKRQNLEKVCPRCGNEDIDDDARYCKICGEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y7</accession>
    <name>C6X5Y7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806110.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01377"/>
    <dbReference type="EnsemblBacteria" id="ACU07825">
        <property type="protein sequence ID" value="ACU07825"/>
        <property type="gene ID" value="FIC_01377"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01377"/>
    <dbReference type="HOGENOM" id="CLU_2493315_0_0_10"/>
    <dbReference type="OrthoDB" id="2156506at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="86" mass="9588" checksum="996DEDD55BCF9FF1" modified="2009-09-22" version="1">MSKIEDVKVLIETFRMERTIYVILTTISAVTLIGLGIYAAVQEQNIAAFVALLVPSGTLTLCIFRVLKMWDDALKYISNNPTDGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X618</accession>
    <name>C6X618_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01408"/>
    <dbReference type="EnsemblBacteria" id="ACU07856">
        <property type="protein sequence ID" value="ACU07856"/>
        <property type="gene ID" value="FIC_01408"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01408"/>
    <dbReference type="eggNOG" id="ENOG502Z92Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553160_0_0_10"/>
    <dbReference type="OMA" id="NRPQINM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970725" evidence="1">
        <location>
            <begin position="33"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="173"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="433"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="501" mass="53024" checksum="50F93FCE1F11F2D4" modified="2009-09-22" version="1">MHNIFNFGKYILKTMKKISLLVAFTISTFAFSQFVSPGTGVSYNLASLSAAAPTVLVNNGSDYQMTANVTISAGDTLEMNEDTTLKINGGIEFTVGGNYTTTANNLLITASDPAVIFRGIRFESTANVAINNTTFEYGGGLQVFTGNFVMENSIVRYFKPGMVTGSSVNFSTGNPVVRNSQFIENQLPAVASGANQSVALEFTNNYLYGNTKDNSNRPQINMGPSGSGITKIINNTIIGNRALTRVGGVSVSTLLGIENHPQIEGNTIKDNRYGITVAGNNSSGSISNNIITDNNTETNPLMGGSGIALSGNGSTAMALKIEKNEIRGNLWGITITGTSQGDLGGGSLGSLGQNIFSNNGNGGEIFALNNVSPHAISAENNCWREGELSDDAMVESIVFHKADDATKGEVDYKPYLCALPLATENSALLKSKIYPNPSNGTFIFDAEKAGNIVISDMSGRNIHSGIVVKGTNTVTVKAKSGVYILQYISEGKKQSNKLIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X681</accession>
    <name>C6X681_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_01471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806204.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01471"/>
    <dbReference type="EnsemblBacteria" id="ACU07919">
        <property type="protein sequence ID" value="ACU07919"/>
        <property type="gene ID" value="FIC_01471"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01471"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022305_0_1_10"/>
    <dbReference type="OMA" id="SAAMGGC"/>
    <dbReference type="OrthoDB" id="225730at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="190"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="472" mass="51582" checksum="839DACD6136BA532" modified="2009-09-22" version="1">MQSISVFEIIKVGIGPSSSHTMGPWNAAENFIKQIRTDHQLSDVQEVFVEFFGSLAKTGIGHGTDIAGMLGLSGENFKLIDTTTIDGKIEEIKSSGTLNLGGEKVIPFRYGHHLILNKEKSLEFHPNGMIFRAVFNNGKDLIQDYYSIGGGFIATKEENSYEKHCVRTLYPCHHGKDVLFNMDRLGLNKISDLIFLNEESWRSKVETEKEALYIWQQIKECIYKGVNKEGILPGGLNVTRRAAGLNRKLLGEKVYRNMDEWFRMVVDAEETFTNINKWVSCFALAVNEENASFGRIITAPTNGASGVIPAVLMYAQAFTEFNSEDDIIRFILVAGEIGTLFKKNATISAAMGGCQAEVGVSSAMAAAGLTEIMGGTPGQVLMAAEIAMEHHLGMTCDPIAGLVQIPCIERNSMGAIKAITAANIAIESDPTKAKVSLDQVIQSMWETAQSMSDRFKETSEGGLAIAVNVAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A8</accession>
    <name>C6X6A8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysS</name>
        <name evidence="9" type="ordered locus">FIC_01499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806231.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01499"/>
    <dbReference type="EnsemblBacteria" id="ACU07946">
        <property type="protein sequence ID" value="ACU07946"/>
        <property type="gene ID" value="FIC_01499"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01499"/>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_10"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="181"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="565" mass="64753" checksum="DCAA40578EEBF8B5" modified="2009-09-22" version="1">MQLSEQEIIRREKLQTLQKMGINAFPAEEYTITHTTKAIKESFAEGEKVQIAGRLMSRRIQGKASFAELQDSDGRIQVYFNRDEICTGDDKTLYNEVYKHLLDIGDIIGIEGELFTTQVGEMTVKVENFKILTKSLRPLPQPRTDENGVTHDAFNDPELRYRQRYVDLIVNPQVKDVFVKRTKLFNAMRTFFNDAGYFEVETPILQSIPGGAAAKPFITHHNALDIPLYLRIANELYLKRLIVGGFDGVYEFSKNFRNEGMDRTHNPEFTALEIYVAYKDYNWMMDFTEKLLEYCAVQVNGSTNATFGEHQIDFKAPYPRISMTEAILNFTGFDITGKSESELFDFAKSIGIDVNETMGKGKLIDEIFGEKCEGNFIQPTFITDYPIEMSPLTKKHRSKEGLTERFELMVCGKEVANAYSELNDPIDQRERFEAQAALSERGDDEAMFIDNDFLRALEYGMPPTSGLGIGMDRLIMFLTNNPSIQEILFFPQMKPEKTIPQIELGEDEKAILEILNSQEEAFLLNELKERSQLSGKKWDKATKNLTKFEMIKVTKTDENVFVNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E7</accession>
    <name>C6X6E7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806270.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01538"/>
    <dbReference type="EnsemblBacteria" id="ACU07985">
        <property type="protein sequence ID" value="ACU07985"/>
        <property type="gene ID" value="FIC_01538"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01538"/>
    <dbReference type="eggNOG" id="ENOG5033JZ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144071_0_0_10"/>
    <dbReference type="OrthoDB" id="1849576at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="145" mass="16638" checksum="78F06E58C5B0A7F6" modified="2009-09-22" version="1">MATIITGLFQSQSQSRRISEDLENAGFAQDDFIIYLQDREVSKEVKTSVWQSFFKDNRTLEDESLVVTVRVRDPEAREQIMKIFTANSAVHTNYFENIKFRDAMSLQFLKRIVALRAKSQISSPREVRHHGQSGGMSSEITFGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB7</accession>
    <name>C6WZB7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">nnrE</name>
        <name evidence="9" type="synonym">nnrD</name>
        <name evidence="13" type="ordered locus">FIC_00527</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_012782132.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00527"/>
    <dbReference type="EnsemblBacteria" id="ACU06985">
        <property type="protein sequence ID" value="ACU06985"/>
        <property type="gene ID" value="FIC_00527"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00527"/>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_10"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARKD"/>
    </dbReference>
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        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="129"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="408"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
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        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU06985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="501" mass="54386" checksum="F8599DDC84DBF996" modified="2009-09-22" version="1">MKIFTTSQIRRADSCTISNGHITALKLMEIAAEACAKWLINNTPESAVFQIFCGKGNNGGDGLAIARLLQQQGLKVNVFSDDAAPGSSECFQINYQRLAEHPQIAVYRYNEAPSFDFDANSVVIDALFGTGLKREITDEFAFLIGFMNTLPFRKIAIDIPSGLFADTATGENAPVIQADDTLSFQFWKKSFLHPETGKYCGNIHILDINLDPDFIAQEPTDEFIIDDVLIKKIYRPRHTFSHKGDFGKTAIVGGSFGKMGAAVLATKAATAAGSGITLTFAPRCGYEILQTSCPEAMFSENGTEHAENFILEPGPTVGIGPGLGTHPETEKAFLSFLKSYEQPLVLDADALNILSINTDQLNTIPLKSIITPHPKEFGRLFGSTADSFGRLTLAKQKARELGIYIVLKDHHTQVITPDGRVFYNISGNPGMAKGGSGDVLLGIITSLLSQHYSAEEAAVFGVWLHGKAGDFAADKFSQEAMLASDLIAELGNVFMELNERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF9</accession>
    <name>C6WZF9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00016"/>
    <dbReference type="EnsemblBacteria" id="ACU06494">
        <property type="protein sequence ID" value="ACU06494"/>
        <property type="gene ID" value="FIC_00016"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00016"/>
    <dbReference type="eggNOG" id="COG4095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135915_1_1_10"/>
    <dbReference type="OrthoDB" id="1844907at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_sugar_transpr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="89" mass="9684" checksum="469057B0CB991C23" modified="2009-09-22" version="1">MDLNPEIIGFIAGGLSSALFIPQIIKIIKEKSAEEISLVTCIIGVVSSGLWLWYGILQDHISMMVTNSIAVAATLILVTCKFIYDKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG9</accession>
    <name>C6WZG9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06504">
        <property type="protein sequence ID" value="ACU06504"/>
        <property type="gene ID" value="FIC_00026"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00026"/>
    <dbReference type="HOGENOM" id="CLU_3389555_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="32" mass="3934" checksum="F2E3E9E49E20EF02" modified="2009-09-22" version="1">MSQRNGVQRFLAKHGYFYSNLFKKYLLLTYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ2</accession>
    <name>C6WZJ2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable iron binding protein from the HesB_IscA_SufA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781674.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00051"/>
    <dbReference type="EnsemblBacteria" id="ACU06527">
        <property type="protein sequence ID" value="ACU06527"/>
        <property type="gene ID" value="FIC_00051"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00051"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_1_10"/>
    <dbReference type="OMA" id="YQLYFDE"/>
    <dbReference type="OrthoDB" id="1891602at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="109" mass="12050" checksum="0E80E0195F472F25" modified="2009-09-22" version="1">MIKVSDHAKEKAIQLMTEDGFRPFEDYIRVGVKSGGCSGLEYVLKFDNQRTDSDQIFEDNGIKIIVEKKSILYLAGTVLEYSGGLNGKGFIFNNPNANRTCGCGESFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL3</accession>
    <name>C6WZL3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HesA/MoeB/ThiF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781695.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00072"/>
    <dbReference type="EnsemblBacteria" id="ACU06548">
        <property type="protein sequence ID" value="ACU06548"/>
        <property type="gene ID" value="FIC_00072"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00072"/>
    <dbReference type="eggNOG" id="COG1179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_4_1_10"/>
    <dbReference type="OMA" id="DMDDICV"/>
    <dbReference type="OrthoDB" id="1543144at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="27754" checksum="58BF468A84491F72" modified="2009-09-22" version="1">MEKNWLERTELLVKESGIGKLQNANLLIVGLGGVGSFAAEFLARSGVGKMTIVDGDVVDITNINRQLPALHSKIGQSKVELVAERLLDINPKIQLTTINEFLNPERMLEVIGNEKFDYILDCIDSVTPKIELIKAAKRKRTKVVSCMGAGGKIDPAKVMVRDISKTYNCFLAKQVRKRLKADKIDKGVRCVFSNEIQDQNSLKMTDGSNYKRSFYGTISFIPAIFGLYAAAEVIRYLLKQNAVDPESADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM0</accession>
    <name>C6WZM0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781702.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00079"/>
    <dbReference type="EnsemblBacteria" id="ACU06555">
        <property type="protein sequence ID" value="ACU06555"/>
        <property type="gene ID" value="FIC_00079"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00079"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_0_10"/>
    <dbReference type="OMA" id="YKVLFDM"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="13"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="426" mass="48739" checksum="A0396D5DBFC7A0A5" modified="2009-09-22" version="1">MADLQSIKARFGIIGNFPALNRALEKSIQVAPTDISVLVMGESGVGKEFIPKIIHGESRRKHQPYIVVNCGAIPEGTIDSELFGHEKGAFTGATSTRKGYFEVADGGTIFLDEVGELPLQTQVRLLRVLESGEFMKVGSSQIQKTNVRIVAATNVNMLKAIEDGRFREDLYYRLNTVQIDMPPLRERKGDIHLLFRKFAIDFAEKYRMPELVLTDDAVKYLEQYHFPGNIRQLRNLVEQMTVVEQNRSINSAKLGEYIPAHNNLPAVVQNSRLGLPSSEFNSEREIMYKILFDMRNDLNDLKSLTSELIKNRGNNDFSHQEKNLINRVFTPENQVQNPNSMLYFEKNANQYQSPNNIDENDEDYGEVEDIEIEETKQNSLSLQNNERELIVKALEKYNGRRNKAADELGISQRTLYRKIKQYNLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM4</accession>
    <name>C6WZM4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00083"/>
    <dbReference type="EnsemblBacteria" id="ACU06559">
        <property type="protein sequence ID" value="ACU06559"/>
        <property type="gene ID" value="FIC_00083"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00083"/>
    <dbReference type="eggNOG" id="ENOG5033X9H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136729_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973268" evidence="1">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="27042" checksum="88AC003FF3BC3746" modified="2009-09-22" version="1">MMRILYVLVFLNSLLFAQTIPAFPADQHSYLGGEVNFYKDFQKILLEKQLKPCTNKKEHVKAGIVVKTDDTAELYSGENAPSTDSKCAEALTAEVLKSMPGWVAAKIDGKNTVALTHYFIYPDAFFDNFETGYTPDNYFKMPVFPGGIQAFRKEVDNRADGSDFYVKGDGKVTLTVIFIVNEEGVMENAMLENSSGLEQYDEMILYSVKSIKKKWMPATIHGVATKYRFRMPISYTNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ2</accession>
    <name>C6WZQ2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781734.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00112"/>
    <dbReference type="EnsemblBacteria" id="ACU06587">
        <property type="protein sequence ID" value="ACU06587"/>
        <property type="gene ID" value="FIC_00112"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00112"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_0_10"/>
    <dbReference type="OMA" id="PPWGPER"/>
    <dbReference type="OrthoDB" id="1668114at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014291">
        <property type="entry name" value="SUF_FeS_clus_asmbl-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02945">
        <property type="entry name" value="SUF_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="108" mass="12258" checksum="BF28738FC8BED568" modified="2009-09-22" version="1">MNYTDDQIADIGENIIKNLKTVYDPEIPVDIYELGLIYDVQISEIGEVKVIMTLTTPNCPVAESLPAEVREKVAEVEGVKEVDLELTFEPSWNKDMMSEEARFELGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU6</accession>
    <name>C6WZU6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA thioester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781778.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00156"/>
    <dbReference type="EnsemblBacteria" id="ACU06631">
        <property type="protein sequence ID" value="ACU06631"/>
        <property type="gene ID" value="FIC_00156"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00156"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_2_10"/>
    <dbReference type="OMA" id="MDEMAFL"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="19234" checksum="2D662574E1263652" modified="2009-09-22" version="1">MGKIKTASESLTVMTNIVLPNETNSLRNLFGGELLAKMDRCASISAARHCERRVVTASVNHVSFNFPIPEGGIVVLESKVSRAFSTSMEIYVDVWLDDPINQTKTHTNEGIYTFVAVDEFNRPIPIPQMEPETEEEILRFDAALRRKELSLIFSGRMKAADSVELKKLFSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV4</accession>
    <name>C6WZV4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781786.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00164"/>
    <dbReference type="EnsemblBacteria" id="ACU06639">
        <property type="protein sequence ID" value="ACU06639"/>
        <property type="gene ID" value="FIC_00164"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00164"/>
    <dbReference type="eggNOG" id="COG2816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_15_0_10"/>
    <dbReference type="OMA" id="PGGFCEP"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="19797" checksum="06DDB9AE4B9E2D7D" modified="2009-09-22" version="1">MENLKFCPKCGHESLRWDGEKKWDCPDCDYVLYHNVAGAVAVIIKCGDEILLTRRNQEPKKDKLDLPGGFVDPKESAEETCVRELSEEMQMNVDISNLRYLASLPNTYLYKSITYNTLDLFFEYEVEEKVVPELEITEISETVWLKLSDINLNDLAFESQKVFLAKYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZX7</accession>
    <name>C6WZX7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781809.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00187"/>
    <dbReference type="EnsemblBacteria" id="ACU06662">
        <property type="protein sequence ID" value="ACU06662"/>
        <property type="gene ID" value="FIC_00187"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00187"/>
    <dbReference type="eggNOG" id="ENOG5033MHH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550632_0_0_10"/>
    <dbReference type="OrthoDB" id="260514at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="509" mass="59608" checksum="2895B1E8D662DCE1" modified="2009-09-22" version="1">MKKTLPKLLTNPFLLILVTVLMKIPLFFTRHMQEDSFITWRVARNLLDFGVIGFNGSEPISASTTHLYVLVSAAFQMLFGAGFIYPLLIFSCILFAVGTHWLAKILFGNEPQKQGVFVLLINMIPPAFTASCLGMEYGILFFLYCGLLYFGIFKNRNWAYLIFPILLLWTRLDAVLFLGVFFVADFIIRKKFNYRFFLGGILGLVSVLLFNFLYFGDVVNHTITAKKIAYKNLVTDNSWQYILYQWAYYGGLIKKYSLFTLGTFIGFIVFLVFCLNKILRNRTEIQFETKVLLLSMVGFALLKITVFAFFKAYFDWYYWLPRVFLFVVVLYYFLQFFNLKNKILRFSLVFLFISLYLFQGLQSYAIGYMEDRQRHRIANDLSAEKSGLNTSILLEPAGIIPFYTGLYTYDEVGLVNKKVTAEMLKDEKFWWINTVRKYKPNYILTVGQRPIAEDSFYNLKADDRAFFNAKYQLMKTYSIAEIHQNAPALLRWIYKIRPIGKDYHLYRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ3</accession>
    <name>C6WZZ3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LmbE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781825.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00203"/>
    <dbReference type="EnsemblBacteria" id="ACU06678">
        <property type="protein sequence ID" value="ACU06678"/>
        <property type="gene ID" value="FIC_00203"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00203"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_1_10"/>
    <dbReference type="OMA" id="EIVLCNA"/>
    <dbReference type="OrthoDB" id="1282433at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023842">
        <property type="entry name" value="Bacillithiol_biosynth_BshB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04001">
        <property type="entry name" value="thiol_BshB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="240" mass="26683" checksum="FA83B4B905AE1796" modified="2009-09-22" version="1">MQKADILAIGAHPDDVELGCGGTLTKLIAEGKTVAIVDLTQGELGTRGTNFTRAEEAAKASEILGISARENLKMKDGFLVNSEENQMQIVKMIRKYQPEIVFSNAVEDRHPDHAKAHKLVSDACFLAGLVKIETTNNGENQIPWRPKQIFSYIQWKNITPDFVVDISGFMNTKIEACLAYKTQFYDPDSTEPMTPIATKDFLESLTYRAQDLGRLSGVEYAEGFTTEKLIAFKNFDGIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X027</accession>
    <name>C6X027_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781859.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06712">
        <property type="protein sequence ID" value="ACU06712"/>
        <property type="gene ID" value="FIC_00238"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00238"/>
    <dbReference type="eggNOG" id="ENOG50317KW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104551_0_0_10"/>
    <dbReference type="OMA" id="EANQEHA"/>
    <dbReference type="OrthoDB" id="1809078at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="214" mass="24747" checksum="D25D9FBC01268728" modified="2009-09-22" version="1">MKKLFLISGLILFLSCHKDPGPAESRNVSADSQLISGQSHNTVANLELKSVEDIKTEYNLVNRLLQEKKLDSASFLYSCAGERQGNVVYYYENRQLRSIRHTYSEYSHFSAVENYFIKDGNVFFIFKKETGWTFDGGTPEKPETRDNSKEFRYYMVNGKPLQCFEKEYTVRSAASANPQPENIKNTEVKNCETDKVLKRYRSLVENQKTKKCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X032</accession>
    <name>C6X032_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RF_PROK_I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781864.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00244"/>
    <dbReference type="EnsemblBacteria" id="ACU06717">
        <property type="protein sequence ID" value="ACU06717"/>
        <property type="gene ID" value="FIC_00244"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00244"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_3_2_10"/>
    <dbReference type="OMA" id="SEHRSQW"/>
    <dbReference type="OrthoDB" id="2047548at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="2">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="130" mass="15028" checksum="840A71BE1EBEF85A" modified="2009-09-22" version="1">MRDFTKELSFKTSRSSGAGGQNVNKVETTVTVMWKPAQTEFFYQSEIALITEKLKNRINLDGILQLTVSESRTQLQNKKIATEKILDIVNKSLIKPKPRTATKPSKRQIEKRITAKKQISEKKENRKFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X076</accession>
    <name>C6X076_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPO candidate 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781908.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00294"/>
    <dbReference type="EnsemblBacteria" id="ACU06761">
        <property type="protein sequence ID" value="ACU06761"/>
        <property type="gene ID" value="FIC_00294"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00294"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076204_1_0_10"/>
    <dbReference type="OMA" id="HCPYVKH"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="186" mass="20967" checksum="2FB95D10A9400306" modified="2009-09-22" version="1">MAQTASNMLELGTKAPFFELPNPSNSNEIQSLENLKGEKGTLVIFMCNHCPFVQHVIDILAELYEDYQDKGIEFIAINSNDAEKYPADAPDKMAEFQVERKFDFPYLFDESQAIAKAYNAACTPDFFFFDDKLDLIYRGQMDDSRPGNNKEVTGEDLIVAFENLLADAPQEETQLPSIGCGIKWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G1</accession>
    <name>C6X0G1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00380"/>
    <dbReference type="EnsemblBacteria" id="ACU06847">
        <property type="protein sequence ID" value="ACU06847"/>
        <property type="gene ID" value="FIC_00380"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00380"/>
    <dbReference type="eggNOG" id="COG3403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090943_0_0_10"/>
    <dbReference type="OMA" id="FICRYRA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014988">
        <property type="entry name" value="Uncharacterised_YqcI/YcgG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40045">
        <property type="entry name" value="PTHR40045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08892">
        <property type="entry name" value="YqcI_YcgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="236" mass="27233" checksum="4735AE1E9D42BD47" modified="2009-09-22" version="1">MAVACSFKIQFMETSTPSTFDLNTIDRDIQSFVVDGGHPCIMAKSVFKMKNYDLHAYADMQGETQIKELLADLETYLQDAGRDSMNFRSFVAVFPNNKFTDEISFENALWATLQQLHEADEMPWDESVSRNPDDAEFSFSLLGKAFYVIGLHTQSSRMARQAPYTTLVFNLHQQFEKLREIGTYQNVRDMIRKNDEKLQGSINPVLKDFGDDSESRQYSGRNVESNWKCPFHHKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Q7</accession>
    <name>C6X0Q7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ordered locus">FIC_00484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782090.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00484"/>
    <dbReference type="EnsemblBacteria" id="ACU06943">
        <property type="protein sequence ID" value="ACU06943"/>
        <property type="gene ID" value="FIC_00484"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00484"/>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_0_0_10"/>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="OrthoDB" id="1661843at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="32429" checksum="FFAE75664278CE6D" modified="2009-09-22" version="1">MKIFKRSKEIQDFVERHKEMGKKVGFAPTMGALHAGHLSLYKAARKENDLVISSIFVNPTQFNNASDLEKYPRDVKTDIQVLEKSGLVDAVYIPEVADIYPDGLTSKSYDFGGIENEMEGKFRPGHFNGVGTVVEELFRQIKPNNAYFGEKDYQQLAVIKRLVALNESGIHIHGVPIFREMNGLAMSSRNQRLSEEQKTASTIIYKTLQKVNDWFRIITIPEINLRVKQIFEAENGMELEYFEIADEETLKETDFFYKDHNYRAFIVVNVGEIRLIDNLHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S4</accession>
    <name>C6X0S4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KTSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01591"/>
    <dbReference type="EnsemblBacteria" id="ACU08037">
        <property type="protein sequence ID" value="ACU08037"/>
        <property type="gene ID" value="FIC_01591"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01591"/>
    <dbReference type="eggNOG" id="ENOG5033A9F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174765_1_0_10"/>
    <dbReference type="OMA" id="VYQAMKT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025309">
        <property type="entry name" value="KTSC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13619">
        <property type="entry name" value="KTSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KTSC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="72" mass="8508" checksum="A1438EDE9CD4550C" modified="2009-09-22" version="1">MQNPNMPSSVIRKYFYKPELQILTIVYVSGAVYDYLDVPQQVFDDFRAAFSKGTYLNKNIKPNFCYEKRDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S9</accession>
    <name>C6X0S9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08042">
        <property type="protein sequence ID" value="ACU08042"/>
        <property type="gene ID" value="FIC_01596"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01596"/>
    <dbReference type="HOGENOM" id="CLU_3270399_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="41" mass="4693" checksum="980B6E660018F75C" modified="2009-09-22" version="1">MQRHPFAERSVAKDIAESGEVFSDRREIPVAPKRINEPELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y3</accession>
    <name>C6X0Y3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate 5-dehydrogenase I alpha</fullName>
            <ecNumber evidence="2">1.1.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.25" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806381.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01652"/>
    <dbReference type="EnsemblBacteria" id="ACU08096">
        <property type="protein sequence ID" value="ACU08096"/>
        <property type="gene ID" value="FIC_01652"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01652"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_10"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="241" mass="27519" checksum="651C615ED064AEA1" modified="2009-09-22" version="1">MAQKKLALIGKNISYSFSKKYFENKFRNLMIDGYTYDLYDLDTESEIEKLLKTPNLRGVNVTIPYKEKVQPFLDELSEEARETGAVNCILIKDNIKKGFNTDAFGFEQTLLLHRKEKHQSALILGNGGAAKAVKYVLQKLMIPYKTVARKEELTFDHLDTETVADHRLIIQCTPVGTFPNVDDCLSFPFEALSADHLVIDLIYNPAMTAFLQNSAQHNAKTVNGLYMLEQQAEKAWKIWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X133</accession>
    <name>C6X133_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01703"/>
    <dbReference type="EnsemblBacteria" id="ACU08146">
        <property type="protein sequence ID" value="ACU08146"/>
        <property type="gene ID" value="FIC_01703"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01703"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024435_0_0_10"/>
    <dbReference type="OMA" id="ETHHGWK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="83"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="403" mass="44798" checksum="719B7C2361AC51E4" modified="2009-09-22" version="1">MRSLFSIKTHTMSKNLLTKILPLAGALIFAQLPAQRGIPPKEVTRITHSTNYPEHLDFLPEMVNLLKTPAGWKVSVAASGLGKPRMLYLMPDGNMYVTRRDAGDVLLLKDPNGDGKFDEVKTVVAEFKGVHGITMKDGMLYLCNNNELRRYKINPDGMLTDKEMLFNDMPSAGQHPNRTMDFGPDGKLYISIGTLCNDCKEMDREAASIVQVDPATWKRTIFASGLRNTIGFDWHPQTSEFWGFDNGGDAKGDDWPPEELNLLQQGKNYGYPFAYAKREVDETREDPAGNSKNEWVETTEPSTMEFQAHMAPIAFQFFPSSAPFSGDGIIAWHGSWNRSKPVGFKVQRVRFANGKPVGAEDFLTGFLKGKTRFGRPAGVAISANGAVYISDDANGVLYRISQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X166</accession>
    <name>C6X166_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01736"/>
    <dbReference type="EnsemblBacteria" id="ACU08179">
        <property type="protein sequence ID" value="ACU08179"/>
        <property type="gene ID" value="FIC_01736"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01736"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_2_0_10"/>
    <dbReference type="OMA" id="GPAVNWA"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="350" mass="38592" checksum="C54FE1053304DC8B" modified="2009-09-22" version="1">MEKIKVSDYGITPAGERVEKFTLENSHGMSVEIITFGAIITSLTVPHKAGNLQNVVLGYADPADYFNGNPYYLGAIIGRFGNRIANAEFELEGKKYTLEANDGVNALHGGKNGFHTKVWKAETVGECALKFTYISDDGEEGFPGELAVSVVYTLTDDNALEVSYQAITDKTTVVNLTQHTYFNLSGDLSESVSDHKIKIESGYFLPTDDAMIPTGELRKVENTPFDFRELKTIGLEIDSEDSEIMKGSGYDHTWVLNGEESKSAATAVHERSGRILEVLTTEPGVQFYTGNHLDGKLKNQSGKSIEKRTGFCLETQHFPDSPNQKDFPSVILKPGEVYESKTVFKFSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C8</accession>
    <name>C6X1C8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl peptidase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806526.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01798"/>
    <dbReference type="ESTHER" id="flab3-c6x1c8">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08241">
        <property type="protein sequence ID" value="ACU08241"/>
        <property type="gene ID" value="FIC_01798"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01798"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_2_0_10"/>
    <dbReference type="OMA" id="MYGERYM"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973333" evidence="1">
        <location>
            <begin position="19"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="125"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="518"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="713" mass="81149" checksum="5A0D83B822DBA1B8" modified="2009-09-22" version="1">MKFSHLSLVFLGFSGLLAAQNQKYTMAEAVNGLRSNLAVKSISQFSWNDDAKSYVQGTKNGYLITEMQSMKQDTLVSLYQINKNLSAEQKFNALPPVKFTSRTQGYFSQKGKYYRLEKSGNDWKTSEWTALNDGAENIQVLADNKSIAYTVKNNLFLNRNGKTVAITSDENEHIVNGQAVHRSEFGISGGIFAAPNSAKIAFYRMDETMVTDYPVIDWSVTPAKNTNIKYPMAGSTSHHVTLGVYDINAQKTTFLNIEGDKEQYLTAVTWSPDSKYIFVGVLNRDQNHLKMNQYDAATGTLMKTLFEEKSEQYVEPQHQLMFFPNSNTDFIWQSQRTGYNHLFHYHLDKGLVSQITKGDWLVTDVLGFNEKKKEIYYASTQQSPLERHLYKINWNNFRTQKLTTAPGMHTGILSKDGSQLYDIYSNATTPRSINFINTSTLQTKNILTSENPLAKYKRPEIKNVNLKADDGTPLYGKIILPTDFDASKKYPVIVYLYNGPHLQLVTNSFPESGNLWYEYMAQNGYIVFTMDGRGSSNRGMKFEQAVFRNMGETEMNDQLKGVDYLKSLPYVDAENMGIHGWSYGGFMTTSFMLKHPEIFKAGVAGGPVIDWNMYEIMYTERYMDSPQQNPEGYAKANLLDKVQNLKGKLLMIHGTQDDVVVWQHSVKFLKAAVDNGVQLDYFVYPGHAHNVIGKDRVHLMQKVTDYFDNHLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H1</accession>
    <name>C6X1H1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase</fullName>
            <ecNumber evidence="4">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01841"/>
    <dbReference type="EnsemblBacteria" id="ACU08284">
        <property type="protein sequence ID" value="ACU08284"/>
        <property type="gene ID" value="FIC_01841"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01841"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_10"/>
    <dbReference type="OMA" id="VDPRSYM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="399" mass="46141" checksum="856C0D87156ADA60" modified="2009-09-22" version="1">MLNNKNKKVIVIDKVNHHMFQPLFYQVACGRIEPSNISFPFRKIFQRSRNIQYRMIEVEKIVPEQNKIVTHDYEIKYDKLVIATGCKTNFFGNNKMESLTFGMKNTQEAIAIRNHVLLTFEKLIIEKQRSDDGNWNIVIVGSGPTGVELAGAFAEMKREILPRDYPHMNFKNLNIILISSTPTSLSTMSEESQKMSEQYLKELGVDFLSAEMVVDYDGDKVYMQSGKTIASNNVIWAAGVTGNIIDGLNPEIMVRNRYRTDRFNRVLGYDNIFAIGDIAYMETPKYPLAHPQVANVAINQGKNVGKNFLKKNEKDWVEYEYTDQGSMATIGKHRAVVDLPNLKFQGFLAWYFWMFLHLMLILSVRNKVAIFFNWMWSYLNKDSSLRLIIIPNKKNRTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J2</accession>
    <name>C6X1J2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806590.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01862"/>
    <dbReference type="EnsemblBacteria" id="ACU08305">
        <property type="protein sequence ID" value="ACU08305"/>
        <property type="gene ID" value="FIC_01862"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01862"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_53_1_10"/>
    <dbReference type="OMA" id="MMYFARK"/>
    <dbReference type="OrthoDB" id="1498437at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="261" mass="29980" checksum="AAA30F12BD392B12" modified="2009-09-22" version="1">MQILHSKIYGEDRQGTPLLVFHGLFGMLDNWGSFGKEMGEFFPVHLIDLRNHGKSFHSEEMSHEVLANDILHYMEFHNLQKVNLLGHSLGGKAVMQFAITYPVKVQKLIVVDISPKAYPPHHQGILKALESVNFDTLATRQEVEEALQQYIPEKSVIQFLAKNLYWTDDKKLNWRFNLRTLSEKYSEFVSNAIKFGVFTGETLFISGAKSNYILPQDEFQIKQQFPNASVVKIENAGHWVQAENPKDFAEVVKDFILEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L7</accession>
    <name>C6X1L7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806615.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01887"/>
    <dbReference type="EnsemblBacteria" id="ACU08330">
        <property type="protein sequence ID" value="ACU08330"/>
        <property type="gene ID" value="FIC_01887"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01887"/>
    <dbReference type="eggNOG" id="COG2731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107139_2_1_10"/>
    <dbReference type="OMA" id="FIDIQIP"/>
    <dbReference type="OrthoDB" id="1857569at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="16957" checksum="E58CA7642C12AE58" modified="2009-09-22" version="1">MIIDSLHNAATYHDLHPLFSKAFEFVNENNLMNLPEGTIQIEDGLKVIVSQKNGKTPEESLQKFECHNASIDIQICVKGAETIGWKPRENCSQPKGEYDPVKDVLFFADEPDMFFNLKDSQFVIFYPGDVHAPMIGEDVIRKLVFKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1N8</accession>
    <name>C6X1N8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806636.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01909"/>
    <dbReference type="EnsemblBacteria" id="ACU08351">
        <property type="protein sequence ID" value="ACU08351"/>
        <property type="gene ID" value="FIC_01909"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01909"/>
    <dbReference type="HOGENOM" id="CLU_1432611_0_0_10"/>
    <dbReference type="OrthoDB" id="2114858at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973601" evidence="1">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="189" mass="22170" checksum="78AC17D81E61F0C8" modified="2009-09-22" version="1">MKKFFSLFALVLCAVALSQKIGIPAKIVFADGSVSESKILFRKSSFYKDELYENSITQKHIVLINGINKREKRLFNEFRQIEFVDLKGKNRTFQRPLEKFGLFELVQDGPKMKWYRDFTENAYDHSQGSYDIFIRNDGEYGFLNMLTNYKKKLKELTSDNSGLAEVIDNCNFFNNTNPCLQKMFNKYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P6</accession>
    <name>C6X1P6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01917"/>
    <dbReference type="EnsemblBacteria" id="ACU08359">
        <property type="protein sequence ID" value="ACU08359"/>
        <property type="gene ID" value="FIC_01917"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01917"/>
    <dbReference type="HOGENOM" id="CLU_3389560_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="32" mass="3831" checksum="EF02FB1D4CE120CC" modified="2009-09-22" version="1">MVVFLRTLKKKFKKIGLSIQKLKFLYGKIDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q8</accession>
    <name>C6X1Q8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806656.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01929"/>
    <dbReference type="EnsemblBacteria" id="ACU08371">
        <property type="protein sequence ID" value="ACU08371"/>
        <property type="gene ID" value="FIC_01929"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01929"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_10"/>
    <dbReference type="OMA" id="EWCQHVQ"/>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="5"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="359" mass="40864" checksum="07837D76356EB49E" modified="2009-09-22" version="1">MHSILITGGAGFIGSHVVREFVKNNPDKKVINLDALTYAGNLENLKDIENEPNYVFEKADITNVDELRKVFEKHRPDAVLHLAAESHVDRSITDPNAFINTNVNGTANLLNLCREFWTLNPDHQHGSFPDETRNNLFYHVSTDEVYGSLGETGFFLETTAYDPQSPYSASKAASDHLVRAYGNTYGMPFIVSNCSNNYGPNHFPEKLIPLCISNILNGKPLPIYGDGKYTRDWLFVIDHAKAIHQIFFEAKTGETYNIGGFNEWQNIDLVKELIKQMDEKLGNPAGHSEKLITYVKDRPGHDKRYAIDATKLNKELGWYPSVTFEQGLAKTIDWFLENKEWLDHVTSGDYQKYYDKQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T6</accession>
    <name>C6X1T6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08399">
        <property type="protein sequence ID" value="ACU08399"/>
        <property type="gene ID" value="FIC_01957"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01957"/>
    <dbReference type="eggNOG" id="ENOG50331AQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162517_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972226" evidence="1">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="128" mass="14360" checksum="9B5BC1DD39588F07" modified="2009-09-22" version="1">MMKTKFYHLLLLLFSLTLFSCDQILDNYWDRKAEENYVSPFKGIYKGNYSGDEVGTLSIEVAKNGYTSVTRIAAFGTEESTFSGMVRDDGALQSVKLESGFTLLGNLNAKSGTWKMGDWNGSWTVQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W0</accession>
    <name>C6X1W0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01981"/>
    <dbReference type="EnsemblBacteria" id="ACU08423">
        <property type="protein sequence ID" value="ACU08423"/>
        <property type="gene ID" value="FIC_01981"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01981"/>
    <dbReference type="eggNOG" id="COG5403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080945_1_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009282">
        <property type="entry name" value="DUF937"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06078">
        <property type="entry name" value="DUF937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="299" mass="32546" checksum="AE5EE03019A77A22" modified="2009-09-22" version="1">MSLIDLITGNAGNQVADQAKNKFGIDKNQVIALLAVAAPLVISYLRKKSQDDPNEAEALNNALDKDHDGSILNDPAQVEARQQEGGSILDHVFGGQKNQVENQLSQKTGISMDKIGPVLAMLAPLIMGYIGKQKQSGGVASGGGLGDLLGGILGGAQNEAQAQPSNPLNDILGSVLGGGSQQSSGNSLNDILGSVLGGNSGGQQQGGLDGLLGSILGENNGLNHKKNRRLFFGFFCFWFCFCGFFGLFRFWFCGCFRFCVGWRFCIFRFSGWITYFFPNFYFRIFFFIFIHHRNRNVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W2</accession>
    <name>C6X1W2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08425">
        <property type="protein sequence ID" value="ACU08425"/>
        <property type="gene ID" value="FIC_01983"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01983"/>
    <dbReference type="HOGENOM" id="CLU_3216570_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="44" mass="5308" checksum="AB280F02CA496FB1" modified="2009-09-22" version="1">MRSEHISKVLKVEFFVSKGKFFRPKMWRQLRLRACISLDLGQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X207</accession>
    <name>C6X207_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="8" type="ordered locus">FIC_02028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806754.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02028"/>
    <dbReference type="EnsemblBacteria" id="ACU08470">
        <property type="protein sequence ID" value="ACU08470"/>
        <property type="gene ID" value="FIC_02028"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02028"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_10"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="6"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="705" mass="78131" checksum="A93B9B64BE920A70" modified="2009-09-22" version="1">MARDLRLTRNIGIAAHIDAGKTTTTERILFYTGKTHKIGEVHEGASTMDWMEQEAERGITITSAATTCKWNFPTNQGTILPDTQEYHFNIIDTPGHVDFTVEVNRSLRVLDGLVFLFSAVDGVEPQSETNWRLADNYKVARMGFVNKMDRQGADFLNVVNQVKEMLGSNAVPIVLPIGSEENFKGVVDLIKNRAIVWDEAGQGATFEVVPIPEDMKADVLEYREKLVEAVADYDDTLMEKFFEDPDSISEDEINEALRKATIDLSIIPMTCGSSFKNKGVQFMLDAVCKYLPSPMDKDNIKGTDPRTDEEIERQPSVNEPFAALAFKIATDPFVGRLAFFRAYSGRLDAGSYVLNTRSNNKERISRIYQMHANKQNPVEYIEAGDIGAAVGFKSIKTGDTLCDEKSPIVLESMIFPDPVIGIAVEPKTKADQDKMGNALAKLAEEDPTFQVKTDEASGQTIISGMGELHLDILVDRMRREFKVEVNQGQPQVEYKENLTSSANHREVYKKQSGGRGKFADIVFELAPADDNKPGLEFINEIKGGNIPKEFVPSVEKGFKEAMKNGPLAGFEIEGIKVTLKDGSFHPVDSDALSFELAAKMGFKEAGKKAKPVIMEPIMKIEVVTPEEYMGDIVGDLNKRRGTINGMDDRNNAKVIKGFVPLSEMFGYVTTLRTLSSGRATSSMEFEKYEAAPQNVAESVIEKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>C6X212</accession>
    <name>C6X212_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Nicotinate phosphoribosyltransferase</fullName>
            <shortName evidence="8">NAPRTase</shortName>
            <ecNumber evidence="4 8 9">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pncB</name>
        <name evidence="12" type="ordered locus">FIC_02033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806759.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02033"/>
    <dbReference type="EnsemblBacteria" id="ACU08475">
        <property type="protein sequence ID" value="ACU08475"/>
        <property type="gene ID" value="FIC_02033"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02033"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030991_1_0_10"/>
    <dbReference type="OMA" id="QAVFHRY"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00570">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="11">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="10">
        <location>
            <begin position="164"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="392" mass="44693" checksum="1F469A6BB8810953" modified="2009-09-22" version="1">MSEVRLKSILDNDFYKITMQNAVVQLFPNERVRYSFINRGNHHFPEGFDVELRKAVNAMAELKLTKTEKEFLRVTCPYLDLPYLDFLGGYHYDPSEVTISQTGNDLEVSVEGEWYRTILWEVPLLALISELHYVMNGFEREPDHAIVSKTMQKANELNTLGVTFAEFGTRRRHSYQVHDMVMDALIQNKNSKFIGSSNVHFAMKYGVKPIGTHAHEWFMFHAAEYGFKMANALSLEHWVDVYRGDLGVALSDTYTTDVFFQQFDKKFAKLFDGVRHDSGDPIEFAQKTIAHYVKNGIDPLFKYIIFSDALNLEKVAEITNACKGKIGISFGIGTNLTNDVGLKPMNIVMKLVAAKSVSGDWIPTVKLSDEHAKYTGDPKMIELAKEFLQIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X230</accession>
    <name>C6X230_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionine synthase</fullName>
            <ecNumber evidence="5">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_02051</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806777.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02051"/>
    <dbReference type="EnsemblBacteria" id="ACU08493">
        <property type="protein sequence ID" value="ACU08493"/>
        <property type="gene ID" value="FIC_02051"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02051"/>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_2_0_10"/>
    <dbReference type="OMA" id="ADCIAMS"/>
    <dbReference type="OrthoDB" id="118138at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="4 5 6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pterin-binding" evidence="9">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="12">
        <location>
            <begin position="311"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="11">
        <location>
            <begin position="408"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="10">
        <location>
            <begin position="558"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="7">
        <location>
            <begin position="418"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="7">
        <location>
            <begin position="849"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="883" mass="99479" checksum="16A807DC236296A1" modified="2009-09-22" version="1">MKYLKLSGLEPLVITPESNFINVGERTNVSGSKKFLRLIKEEKFSEALDIARHQVDGGAQILDVNFDDGLLDGKECMVKFLNLIASEPDISRIPIMIDSSKWEILEAGLQVVQGKCVANSISLKEGEATFIDQARKIRRYGAAVVVMAFDESGQADNYERRIEICERSYRILTEQVNFPAEDIIFDLNIFPVATGMDEHRRNALDFIEATAWVRQNLPHVSVSGGVSNVSFSFRGNDSVRSAMHSVFLYHAITVGMNMGIVNPALLEVYDEIPKDLLELVEDVMLDRRDDATERLLDYSERVKSTKKEVVEELEWRNLPLQQRITHALVKGVDSFIIEDAEEARTLTERPLDVIETNLMAGMGIVGDLFGSGKMFLPQVVKSARVMKKAVAYLQPFIEAQKDQTQKANGKILMATVKGDVHDIGKNIVSVVLGCNNYEIIDLGVMVPAEKIIQAAIDHQVDAIGLSGLITPSLDEMVHVAAELQRRNLNFPLLIGGATTSKAHTAVKIFPNYEFPVIHINDASRAVGVVSQLLDSNSQRFKEDLKSDYEDFRQKFLSRQIDKEYISIEEARKQRFSIEWQNEMITKPKTLGIHIIENQDLNELLTYIDWTPFFRSWELFGKYPQILNDEVVGEQARELFNDAQKILKQILDGNLFTAKGIFGIFPANSNESDDIILQSGSQSFTFHTLRQQHKKSDGKEYLALSDFIAPQNSGIQDYVGAFAVTTGFGTEELAQKYYAEGDDYNAIIVKALADRLAEAFAEFLHYKVRTEFWGYAENENLPNEDLIAEKYSGIRPAPGYPACPDHLEKLTIWELLKVKENIGLELTDSLAMFPTAAVSGYYFAHPNAKYFGVGKIAEDQLKDYTERKNVDLEYARKWLSPNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X231</accession>
    <name>C6X231_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806778.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02052"/>
    <dbReference type="EnsemblBacteria" id="ACU08494">
        <property type="protein sequence ID" value="ACU08494"/>
        <property type="gene ID" value="FIC_02052"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02052"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_3_0_10"/>
    <dbReference type="OMA" id="AQEDYKM"/>
    <dbReference type="OrthoDB" id="1149455at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="336" mass="36896" checksum="8B896A1728DF683D" modified="2009-09-22" version="1">MISKKSIIPQLNHRILVLDGAMGTMLQHYKFTEEDYRGDRFQTWAHSLKGNNDLLSLTQPLAIEEVHRKYLEAGADIIETNTFSATTIAMADYHLEDFVYELNFESAKIARKICDEFTLSDPQKPRFVAGSIGPTNKTASLSPDVNDPGYRAITFDELRIAYKQQSEALLDGGADILLVETVFDTLNAKAALFAIDEIRGERGIDIPVMVSGTITDASGRTLSGQTAEAFLISVSHLDLLSIGFNCALGAQQLTPYLEEIAEKSGFYVSAYPNAGLPNAFGQYDESPERMAEQIKEYLDRKLVNIIGGCCGTTPAHIKAIADLVKDYSPRQVGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X245</accession>
    <name>C6X245_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02066"/>
    <dbReference type="EnsemblBacteria" id="ACU08508">
        <property type="protein sequence ID" value="ACU08508"/>
        <property type="gene ID" value="FIC_02066"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02066"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045539_5_1_10"/>
    <dbReference type="OMA" id="RWSKSDC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="319" mass="36129" checksum="8B3446B35B523918" modified="2009-09-22" version="1">MIKMKKLGFFWETLKETFTEWNNSPAGTDSASLAYYAIFSIPGLLIIIIWIAGYFFGQEAIQGQISNQIGGMMGGNVADSIEEMIAGALIDKENIFMKIVGIFSLVFGATTIFFQLQKSLNNLWDVEPAPKKAFVKFFLDRANSLGMILVIGFLLMITMVLSSLISLFNNYIAAQFGLETYYLMELVNFVIGFLLVMLVFAFMFKVLPDAEIRWKSVWAGATLTAALFTIGKFLLSFYFAEFKPESAFGKAGTIILIMMWINYSCMLIFFGAEYTKVYSRKKGYKIVPSKHAKWSSEKLYRKKLEEMSELGKTAEMEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X259</accession>
    <name>C6X259_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">1-aminocyclopropane-1-carboxylate deaminase</fullName>
            <ecNumber evidence="7">3.5.99.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.7" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806806.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02085"/>
    <dbReference type="EnsemblBacteria" id="ACU08522">
        <property type="protein sequence ID" value="ACU08522"/>
        <property type="gene ID" value="FIC_02085"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02085"/>
    <dbReference type="eggNOG" id="COG2515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048897_0_0_10"/>
    <dbReference type="OMA" id="YHFGGYA"/>
    <dbReference type="OrthoDB" id="1714795at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="13"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="304" mass="34492" checksum="125BBF03B23ADD5D" modified="2009-09-22" version="1">MIIPDTAIPIIELSLKKNIRLFIKREDLIHREISGNKYWKLFYNINNYRKLNPPKPMVITFGGAYSNHITAVSALGNEMQMRTFGIIRGEEIAQKWHENPSLSAAHSNGMELRFVTREAYRDKNTLTESLQKDFPQALIIPEGGTNEAAVEGIRHMLDEQTKSFDYLCTAVGTGGTLAGMSKFAEEHQKILGFKVVNDQSLNESVLRFSGRDNFKLINSHDGGYGKITDGNIRFINKFSEKYGIQLDPVYTGKMMKSLFELIEDDFFPDNCRILVFHTGGLQGIQGANERLKKQKRPLIKVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X268</accession>
    <name>C6X268_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02094"/>
    <dbReference type="EnsemblBacteria" id="ACU08531">
        <property type="protein sequence ID" value="ACU08531"/>
        <property type="gene ID" value="FIC_02094"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02094"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_1_1_10"/>
    <dbReference type="OMA" id="FAERLEC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="299" mass="34083" checksum="3BC1F03E02CF4152" modified="2009-09-22" version="1">MAPMCFLLPYINPIKKIVIYLCLYFLVKMNFSEHLHRGYLNRKSDIDKRKTEDFIDRFFRFIFYLELQRCAELSLIEERLNSFRTEFDEILSAAMQGAETAESEYFFSRFPEIYRHLEEDAQFIFENDPAANSVEEVMFSYPGFFAIAVYRFSHELVKNNVPLIPRIWTEFAHSKTGIDIHPGAQIGRNFFIDHGTGIVIGETTVIGDNVKLYQGVTLGALSVTKALQNEKRHPTIGDNVVIYANATILGAETVIGENSLIGGNVWITESVAPNSVVFHKGLVTVKNKLPVNEPINFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X270</accession>
    <name>C6X270_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_02096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806817.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02096"/>
    <dbReference type="EnsemblBacteria" id="ACU08533">
        <property type="protein sequence ID" value="ACU08533"/>
        <property type="gene ID" value="FIC_02096"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02096"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072818_0_0_10"/>
    <dbReference type="OMA" id="FYIANTK"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="10">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="244" mass="28091" checksum="88EEAAF0EA9A19EF" modified="2009-09-22" version="1">MPEGPTILNLTSKISRFKGKTVTDATGYAEMDKTGIAGQKLMAIDAYGKNFIFVFKDFFVTVHLGLFGSMLINKRKKSNASFALHFDDKEINFYIANTKKIDGKPQDHFNYNTDILKKTFDGEYVLSTLQEKYAEKMIGDALMDQDLFTGVGNIIRVESLYRAKIHPESVIRNIPEKKLVFLIETVVNYAYEFLEQSKEDTVKEKTLIYGKKICPKDKWELIIEEMGKVKRKTYVCPKCQKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B2</accession>
    <name>C6X2B2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806859.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02139"/>
    <dbReference type="EnsemblBacteria" id="ACU08575">
        <property type="protein sequence ID" value="ACU08575"/>
        <property type="gene ID" value="FIC_02139"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02139"/>
    <dbReference type="eggNOG" id="ENOG502ZBU9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1641884_0_0_10"/>
    <dbReference type="OMA" id="HRLHPEK"/>
    <dbReference type="OrthoDB" id="1472055at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045534">
        <property type="entry name" value="DUF6428"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20001">
        <property type="entry name" value="DUF6428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="152" mass="16994" checksum="838B80ED76B632E5" modified="2009-09-22" version="1">MKLSELKQILPTLTSVDFQLENSTFVPEHFHVTEVGQVTKNFIDCGGVTRQETRVNFQLWDANDFEHRLKPGKLLKIIQLSEDILKIEDSEIEVEYQNGTIGKFGLDFNGKNFILTNKTTACLATDACGIPQEKAKVQLSEISKCAPNSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B9</accession>
    <name>C6X2B9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806866.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02146"/>
    <dbReference type="EnsemblBacteria" id="ACU08582">
        <property type="protein sequence ID" value="ACU08582"/>
        <property type="gene ID" value="FIC_02146"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02146"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_4_1_10"/>
    <dbReference type="OMA" id="TYVPQCT"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MannoseP_isomer" evidence="1">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="115" mass="13691" checksum="F8ADCFA6F775055B" modified="2009-09-22" version="1">MLEIGERPWGKYYVLEDETHFKLKRIEVNPGQRLSYQYHHHRQEFWTIVEGNAVVVLDDAEHHLTYGESIFIPQGAKHRIMNLSEKPVIFIEVQTGTYFGEDDIVRLEDDYDRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G4</accession>
    <name>C6X2G4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806911.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02191"/>
    <dbReference type="EnsemblBacteria" id="ACU08627">
        <property type="protein sequence ID" value="ACU08627"/>
        <property type="gene ID" value="FIC_02191"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02191"/>
    <dbReference type="eggNOG" id="ENOG5032TSW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129762_0_0_10"/>
    <dbReference type="OrthoDB" id="1517289at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973372" evidence="2">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="19123" checksum="A8C32E574A1A5870" modified="2009-09-22" version="1">MKTAIILFFLFTFFSIYAHAQNVAVLNINLYPVQTIEVNSASQTVDLDYKTRDDYQDGVSVTKTDHLKIFSTAAFAVKVRSEKPTLTNPDSTNSINSSDITMTASQGTSNSGGSFTSSPVQLSGSDAEFLSSSKGGANNTFNVKYAASGGDKYINKRVNGQSPTVYTTQVVFSIEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J4</accession>
    <name>C6X2J4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02222"/>
    <dbReference type="EnsemblBacteria" id="ACU08657">
        <property type="protein sequence ID" value="ACU08657"/>
        <property type="gene ID" value="FIC_02222"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02222"/>
    <dbReference type="HOGENOM" id="CLU_3251865_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="42" mass="5064" checksum="1C87C63C6C188445" modified="2009-09-22" version="1">MTKFLMSSTQDFMTFFKEKWLVTLAVVVIFVGYKYFFSKEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M2</accession>
    <name>C6X2M2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806969.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02252"/>
    <dbReference type="EnsemblBacteria" id="ACU08685">
        <property type="protein sequence ID" value="ACU08685"/>
        <property type="gene ID" value="FIC_02252"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02252"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_10"/>
    <dbReference type="OMA" id="GALPHMY"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="237" mass="25268" checksum="CFD5F858E551346E" modified="2009-09-22" version="1">MNLNGKTAIITGGSRGLGKAVALMLANEGVNVGITGRNEETLKNTAAELAETGVKVAFAAFSMENEAEVKSGIQQLASELGGVDILINNAGIGDFGSLTEMPSETWEKVLKTNLFGVYYAAMAVYPYLKERKEGDIVNIASTAGLKGGANMSAYAASKAAVISLSQSMMAEWRKENIRVITLTPSTIATDLAIDNNLTDGNPEKVLQPEDFAEWVRDILKMNRRAMIANASIFSTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P1</accession>
    <name>C6X2P1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rbsK</name>
        <name evidence="12" type="ordered locus">FIC_02271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02271"/>
    <dbReference type="EnsemblBacteria" id="ACU08704">
        <property type="protein sequence ID" value="ACU08704"/>
        <property type="gene ID" value="FIC_02271"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02271"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_10"/>
    <dbReference type="OMA" id="LVQCEIP"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="11">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="312" mass="33742" checksum="CBCD217F23F9A843" modified="2009-09-22" version="1">MFYTALSSFIIISHAMNITPEQPKIIVVGSSSIDLVLNTNHLPKPNETVMAEKSESFFGGKGANQAVGTARLGASVYFIGCVGMDPFGQQILRNLVDEGVNVGYVVETEQAATGAAYVSTSEGINSIVVVPASNFCLTPAHVSEAEKYFATADLVLVQLEIPMETVEYTAELARKNGTKIGLYASPATKLSPDLIDASTFIVAKSNELSILFGEDKREEILKKYPNKLFVRDDSNSTTYYNGSEMKYYRNDHDSVLHKMGMGDAFTAGFAVAMCHGNSVDECVKFGNDVSLKVTKNCGSQSGLPYLKDFSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R4</accession>
    <name>C6X2R4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">FIC_02294</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807011.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02294"/>
    <dbReference type="EnsemblBacteria" id="ACU08727">
        <property type="protein sequence ID" value="ACU08727"/>
        <property type="gene ID" value="FIC_02294"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02294"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_10"/>
    <dbReference type="OMA" id="MVRVHHL"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="367"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU08727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="481" mass="53634" checksum="FDE169AC78E68751" modified="2009-09-22" version="1">MNKYLKKTKIIATLGPASSDKETMLQLIQAGTDVFRINFSHADYDLVRKNVESIRQLNQEYGYSVGILGDLQGPKLRVGVVKEGSYLNPGDILTFTNEKIEGDSTRVYMTYQKFPQDVKAGERILIDDGKLVLEVIETNNIDTVKAKTIQGGPLSSKKGVNLPNTNVSLPALTEKDIEDANFMLDLELDWIALSFVRHAQDIIDLKEIIKNHPTNKQKTPIIAKIEKPEGVRNIEQILMECDGLMVARGDLGVEVPMEEVPAIQKNLVEIARKHSKPVIIATQMMETMISSLTPTRAEVNDVANSVLDGADAVMLSGETSVGRYPVDVVRNMAKIVKNIEQTHFYKNKNSPIEHEFNCVDERFITNRVCLAAVRIAKTANVEAIITLTYSGYTAFQISAHRPNSNIIVFSSNKRVLTMLNLLWGVRAFHYDMQKSTDETIIQVNMLAHTHGFVEQGDFVININATPAYEGGKTNTLRLTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S4</accession>
    <name>C6X2S4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08737">
        <property type="protein sequence ID" value="ACU08737"/>
        <property type="gene ID" value="FIC_02304"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02304"/>
    <dbReference type="eggNOG" id="COG2859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077423_0_0_10"/>
    <dbReference type="OMA" id="YYYTKLA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016907">
        <property type="entry name" value="UCP029033"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029033">
        <property type="entry name" value="UCP029033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="29250" checksum="3F457BA29905E3D7" modified="2009-09-22" version="1">MITFSRLSMSIFLTFNKQSDHLMNRNIIAIAIAAAGFIIGLAFLGSAIKNRNQSENTISVTGLGTKKFTSDLIAWSGNFSRNSFELKSAYDELANDKKIIENYLTSKGIAKHEMVFSAVDIQKQFNYGSDASGRSTQTFAGYQLSQRVSIDSKEVSKIENLSRNITEIINLGIEFTSSPPNYFYTKLADVKQQMIADATKDAKQRAEKIAENAGSSLGNLKKATMGVTQITEPNSTEEYSYGGTFNTSSKEKEASITIKLEYQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T5</accession>
    <name>C6X2T5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02315"/>
    <dbReference type="EnsemblBacteria" id="ACU08748">
        <property type="protein sequence ID" value="ACU08748"/>
        <property type="gene ID" value="FIC_02315"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02315"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_2_10"/>
    <dbReference type="OMA" id="DDVIYMR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973385" evidence="6">
        <location>
            <begin position="25"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="8">
        <location>
            <begin position="100"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="7">
        <location>
            <begin position="296"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="502" mass="55912" checksum="B07FC07D3E5CDE2A" modified="2009-09-22" version="1">MKFFNKKAILLAAASALLTLGVSCERDYLATGPTDAVGDQTIYATVSNMSTVINGMHRNMYVRQNSSQGQNGGTSVLMYMDVMGEDLIFPATGPNWFVSTIRWLDNANANSTNVFYPYDFYYEQIRMANALIANGPTATGSQSDREKVMGEAYAFRAYSYMMLVQIYAKRYVQGSANTQLGVPIRLDDTFDAIPRATLDENYAQIKSDLQQAVTMLTGKTRGDKSHFNAEVVKGLMARVALTTGDYAAAATYAREARQGFALMSNATYKEGFNNYAVSEWMWGYKPIADTSDYFGNFMAYMSRNYNSSQIRQAPKVVNKLLFDSFPSTDVRTQVIDPTGAHASLNLPATYLKVPYTSQKYLSTDGSKVDNNTSLGDIPFMRAAEMYLIEAEALARDNKEAESKVVFTQLEKNRNPAYVTSVSTGAAYINEILNSRRLELWGEGFRFLDLKRLNLPLDRTLTNHAPVVTNNLLTVPAGDKRWTWLIPQAEIDASKGLVIQNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V1</accession>
    <name>C6X2V1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LPS biosynthesis related glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807048.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02331"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08764">
        <property type="protein sequence ID" value="ACU08764"/>
        <property type="gene ID" value="FIC_02331"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02331"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074336_0_0_10"/>
    <dbReference type="OMA" id="DFPIRYF"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="32576" checksum="708F1399D5D0C83A" modified="2009-09-22" version="1">MLFTVFTPTYNRAHLLGRLFESLQRQTARNFDWLIVDDGSEDETEASVAQFIAEANFPVRYFRQKNQGKHIAINAAVEQADGDWYLPVDSDDFLADNCLEICESLAEEASAASFAGFTFIHAPEELVGKTQSYGTKKWTGYNSYKWDFAGEMHYVFKMEMIRKFPFPLFEDENFCQESVQVIPIVKSHIILYTDHILAFGDYLEDGLSQNLYARLLKNPRYAMLAFKTKLQMAQTREERMALTQNYWDIVLKTKQPTLKAFLAFPIAFSVPFLGKKLMNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X353</accession>
    <name>C6X353_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="8" type="ordered locus">FIC_02433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02433"/>
    <dbReference type="MEROPS" id="M41.A17"/>
    <dbReference type="EnsemblBacteria" id="ACU08866">
        <property type="protein sequence ID" value="ACU08866"/>
        <property type="gene ID" value="FIC_02433"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02433"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_10"/>
    <dbReference type="OMA" id="QYGMTER"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="237"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="245"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="677" mass="74807" checksum="A073EE34332A8537" modified="2009-09-22" version="1">MTKPSFVKIFINNMNKNKGFNWFFPIVIAAILLIFFTNMNSDSASNTLDEEGFYTLLQQGKVQDVLIYKDTEKADVFLTKAAKTELASKKAAADNSPFAAFDLAPKPDFTLSFGDLQLFLEKFDKIKQDNPALTTKKDYGIGKNPMTELLFTALFWIGIMALFYFVIFRKMMGGGGGGPGGQIFSIGKSKAKLFDEKDKVQVTFKDVAGLEGAKEEVQEVVDFLKNSDKYTKLGGKIPKGVLLVGPPGTGKTLLAKAVAGEAKVPFFSLSGSDFVEMFVGVGASRVRDLFAQAKAKSPAIIFIDEIDAIGRARGKGNFTGGNDERENTLNQLLTEMDGFGTDTNVIVMGATNRADILDKALMRAGRFDRSIYVDLPELHERREIFDVHLAKIKLEPNIDREFLAKQTPGFSGADIANVCNEAALIAARNDHESVTKQDFLDAVDRIIGGLEKKNKAIKPSEKRRVAFHEAGHATISWLVEHAAPLLKVTIVPRGRSLGAAWYLPEERQLTTTEQMYDELCATLGGRAAEQVIFGNISTGALSDLERVTKQAQAMVTIYGLNEKIGNISYYDSSGQSEYNFGKPYSDQTAKMIDEEISKIIETQYQRAVMILTENRDKLDALAAKLLEKEVIFREDLEEIFGQRAWDPELTERPVSNTQVIENEIPEVPGTPEPNTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X359</accession>
    <name>C6X359_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807156.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02439"/>
    <dbReference type="EnsemblBacteria" id="ACU08872">
        <property type="protein sequence ID" value="ACU08872"/>
        <property type="gene ID" value="FIC_02439"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02439"/>
    <dbReference type="eggNOG" id="ENOG50340S1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2206161_0_0_10"/>
    <dbReference type="OrthoDB" id="2065719at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012640">
        <property type="entry name" value="Membr_lipoprot_lipid_attach_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08139">
        <property type="entry name" value="LPAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970605" evidence="3">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="107" mass="11933" checksum="42846A1AD7C680B7" modified="2009-09-22" version="1">MKRLYSIFVLGAVLLLASCQTRVVSLDKPFERNALELYQKYTFQLNDASIVKMEVLRIDSENVYGKTKDGSQVVIKQSDIREARKLDILSSVAVVLAAVAAVIFVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X395</accession>
    <name>C6X395_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02475"/>
    <dbReference type="EnsemblBacteria" id="ACU08908">
        <property type="protein sequence ID" value="ACU08908"/>
        <property type="gene ID" value="FIC_02475"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02475"/>
    <dbReference type="HOGENOM" id="CLU_2915763_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="61" mass="7232" checksum="E815FF26085D39FB" modified="2009-09-22" version="1">MKEYSLNIKIFGGLSQGHRQIFDGRFRAGNWFDINILMHYSKLINNKSKSGKKWELLEIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B0</accession>
    <name>C6X3B0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02490"/>
    <dbReference type="EnsemblBacteria" id="ACU08923">
        <property type="protein sequence ID" value="ACU08923"/>
        <property type="gene ID" value="FIC_02490"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02490"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_0_0_10"/>
    <dbReference type="OMA" id="EIAYVYQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="367" mass="40856" checksum="1728E33A84B912D4" modified="2009-09-22" version="1">MLLKNNIMPNRKHQISEVKIKQIFLLAVILLLAGIICYHLALFIPAVLGAITLYIISRKYNIYLQEEKEWKPWAASTVIIVATLIILILPIYFIGDLLIEKLGNASAYMQKFNVFVDKIHDYVYSKTKIDVLSKDNLNKLKDSVGKYSTLALSSTFNTLTVVASMYFILYFMLEKPRLFERLVKSSAPLKKSNINLLGDKIRKMVIANAIGIPVVAIGQGIVAVIGYFIFDAPSAILLFALTAVASMIPIVGAAIVYVPVCIFMIAEGNTGQGLGLAAYCMVAVGLTDNLLRFTLLKRLENIHPLNTVFGIIVGMKIFGFMGLIFGPILVSITVLLIQVYRDEFSEDENELIMPEPKEIEEKIDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B4</accession>
    <name>C6X3B4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807211.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02494"/>
    <dbReference type="EnsemblBacteria" id="ACU08927">
        <property type="protein sequence ID" value="ACU08927"/>
        <property type="gene ID" value="FIC_02494"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02494"/>
    <dbReference type="eggNOG" id="ENOG5032VPP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1567640_0_0_10"/>
    <dbReference type="OMA" id="AFRHAFW"/>
    <dbReference type="OrthoDB" id="758484at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="20072" checksum="65FF34B0926F60B5" modified="2009-09-22" version="1">MTRTVRIFFNTFRSLSFSKIFTLLKLWVPHPLFTVLAMYATAKSFALAQEYFPKTNSNSGVGNAFRHALWTCLIMMYCCKVSSPEKSLRYCKKMTDLHEELFPNEPLEKKMDLHNNQVGMKLFMNLLQGVHRQFFETSFFIDHLLAKTKTARIIDNPDGSYGDDLVYLEDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D1</accession>
    <name>C6X3D1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02514"/>
    <dbReference type="EnsemblBacteria" id="ACU08944">
        <property type="protein sequence ID" value="ACU08944"/>
        <property type="gene ID" value="FIC_02514"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02514"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035211_3_0_10"/>
    <dbReference type="OMA" id="ANEWGIG"/>
    <dbReference type="OrthoDB" id="1720318at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TPM_phosphatase" evidence="4">
        <location>
            <begin position="56"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="186" mass="21418" checksum="DB73B166A4ED6F9D" modified="2009-09-22" version="1">MKHSTVLYKINMKKIYLTCFWCFLVLACTTNQKESLATEIVKAENQKKFPKYIGCVSDFEKVFTDGEKASITTILEDYETKTTNEIAVISLDENVEIQNFDQYALDLSNTWGIGKAEKNNGLTIVFSKKLKKIRICTGTGTEKILNDKLCEKVLNEQILPEFRKDNYYTGIVNGINEFIKLWELQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H5</accession>
    <name>C6X3H5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807272.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02558"/>
    <dbReference type="EnsemblBacteria" id="ACU08988">
        <property type="protein sequence ID" value="ACU08988"/>
        <property type="gene ID" value="FIC_02558"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02558"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103294_0_0_10"/>
    <dbReference type="OMA" id="FATFKPE"/>
    <dbReference type="OrthoDB" id="1702213at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970618" evidence="1">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24023" checksum="A2A048E701C38861" modified="2009-09-22" version="1">MKNLFLALFLFASASAFSQTAYEKTMTDKIAQVQQQKTADEFTALANDFKRIGDKEKTQWLPYYYAAFATIQKGRLAMRDGKTADLDPIAAEAQKSLDMAMSLNADNAENYILQKMIHGLKMMVNPQERFMSEGMLAAEALSKAEKLDAQNPRISLMKAEDIYYTPEQFGGSKAKGLETFQKSLDQYKTYKAKSAIDPNWGQDEAEYFLANKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J1</accession>
    <name>C6X3J1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-N-acetylmuramate--alanine ligase</fullName>
            <ecNumber evidence="9">6.3.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.8" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807288.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02574"/>
    <dbReference type="EnsemblBacteria" id="ACU09004">
        <property type="protein sequence ID" value="ACU09004"/>
        <property type="gene ID" value="FIC_02574"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02574"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_1_10"/>
    <dbReference type="OMA" id="HLEHYNN"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="8">
        <location>
            <begin position="118"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="7">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU09004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="458" mass="50056" checksum="D8C8C3CC9DDEE1E9" modified="2009-09-22" version="1">MVKTIEEFQDVFFIGIAGVGMSAVAQYLKGIGKDVSGSDRYFHPDEYNRTKDQLEAEGIKCHLQDGSGISEKTDLIVVSTAIEDTVFEVQKARELGIPIVKRSELLAAIAKSKKTIAVGGTSGKSTTSAMLYQILLDAGFDPSIISGAGLTSIIRQGKIGNAAVGKGEWLIIEADESDGSIIQYQPEIGLLLNIDKDHQEIDELITLFSEFKSNTNSLFVVNQSNTLAKSLSANAANDFGFEDANAGYSAENFKQDGLLMTFELRGQKFKMNSLGRHSVENAAAAIAVAHQIGVDLNTSAESLAKYEGIYRRHQILGQKNGVWVIDDYAHNPAKCAASIRACQPLADKVIAWFQPHGYGPTRFLRNDFVEEIAEALRQQDEIWMSEIFYAGGTAVKDISANDLVEDIRMKGKNASFVEDRNNLLEALRPKLTPGTVLLLMGARDPGLEEFCTNLFETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J7</accession>
    <name>C6X3J7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ordered locus">FIC_02580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807294.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02580"/>
    <dbReference type="EnsemblBacteria" id="ACU09010">
        <property type="protein sequence ID" value="ACU09010"/>
        <property type="gene ID" value="FIC_02580"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02580"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_10"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="7"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="399"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU09010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="620" mass="69281" checksum="D271AC27A6DCAEDD" modified="2009-09-22" version="1">MISEIYDVIVVGAGHAGSEAAAAAANMGSKTLLITMNMQTIGQMSCNPAMGGIAKGQIVREIDAMGGYSGIIADKSAIQFKMLNLSKGPAMWSPRTQNDRMLFAEEWRIALENTPNLDFFQDMVKSLIIENNKVCGVVTSLGIQIRGKSVVLTNGTFLNGLIHVGDKQLGGGRMGEPRAFGITEQLVSLGFEAGRMKTGTPPRVDGRSLDYSKMEEQKGDENPQKFSYSDTPTLTKQLSCHIVYTNETVHEILKEGFDRSPMFNGTIQSIGPRYCPSIEDKVNRFAERTRHQLFVEPEGWRTVEIYVNGFSSSLPEDVQIKAMKHIPGFENVKVFRPGYAIEYDYFPPTQLHHTLETKLIENLYFAGQINGTTGYEEAAGQGLMAGINAHNKVKEKEEFILKRDEAYIGVLIDDLITKGTEEPYRMFTSRAEYRLLLRQDNADVRLTEKSFNIGLADEHRLKNVQNKIAQGSELEGFLRETSLKPGIINPILAEIESAPVDQAYKASQILTRPNMTLQKLEQIDFIKERSSEFSDEVKEQAEINIKYKGYIDKERESVAKMTRLETIAIPEDFDFCKINSLSAESRQKLNKVRPRTIAQAGRISGVSPADMNVLLIYLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K0</accession>
    <name>C6X3K0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00530"/>
    <dbReference type="EnsemblBacteria" id="ACU06988">
        <property type="protein sequence ID" value="ACU06988"/>
        <property type="gene ID" value="FIC_00530"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00530"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_10"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="57"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="442" mass="49578" checksum="0CE15B42A46FF55A" modified="2009-09-22" version="1">MQVNFRKLSPFKTTISILISNTPLAEQMRPKTLDEVRGQEHLTGEKGTVRKMLENDTLNSLIFWGPPGTGKTTIAEIISEQSGRKFFKLSAVSSGVKDVREVIEEAKKQNLFSGKSPILFIDEIHRFNKSQQDSLLHAVEKGWIVLIGATTENPSFEVVSALLSRSQVYVLKSLSYEKLEELAELSLKNYNASHGTEFRIKDKEAFIQYSGGDARKLINSVENVLNNFKNSDKKEISNADVLEVLQETMALYDKNGEQHYDIISAFIKSMRGSDPNGAVYWLARMLVGGEDVKFIARRMLILAAEDIGLANPNALVIANNCFQAVNVIGNPEARIILSETTVYLAVSPKSNSTYLAINEAMAFVKKTGNLPVPLHLRNAPTKLMKDLNYGKDYDYAHSHEGNFVDLEFLPDEISGEKFYNPGNNSTENKIKEELNRKWKGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L8</accession>
    <name>C6X3L8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00548"/>
    <dbReference type="EnsemblBacteria" id="ACU07006">
        <property type="protein sequence ID" value="ACU07006"/>
        <property type="gene ID" value="FIC_00548"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00548"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030246_1_0_10"/>
    <dbReference type="OMA" id="INVSMEP"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="461" mass="50413" checksum="D06FF5E2BE005752" modified="2009-09-22" version="1">MAKRIKPDLSIAQIINMSMGFLGIQMAFGLQNGNASRILANLGADVHQLSWFWLVAPITGLIVQPIIGHMGDNTWSPLGRRKPYFLIGAVLCAIGLVLLPNAASVTHLIAANVLLLAVIFLAMMDFSVNIAMEPFRALVGDMLPKHQGTLGFSIQTILIGVGAVIGSEMPNWLTKMGVSNVAPEGYVADNVIFAFYVGAGVLITSILYTIFTTREYSPKEFAEFDGREEATEEKSKFSDMFRDFAKIPPLMKKLGAVQFFSWFALFTMWVFTTSALATHHFGLSPDDTKSAEFNRAGDLTGHLFGLYNLFAIPFAFLLTPIAKAIGKKQTHALALFSGGLGLISMFFIKDTSMLWISMIGLGFAWASILAMPYAMLIDAIPLRKMGVYMGIFNFFIVMPQIVNGIFGGPIVKNLFGNMAIDYVVVGGVCLIIAAAVTMFLIKGEGKEADKELDEEIRQVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M5</accession>
    <name>C6X3M5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purD</name>
        <name evidence="10" type="ordered locus">FIC_00555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782160.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00555"/>
    <dbReference type="EnsemblBacteria" id="ACU07013">
        <property type="protein sequence ID" value="ACU07013"/>
        <property type="gene ID" value="FIC_00555"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00555"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_10"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="105"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="412" mass="45204" checksum="7DFF2727613FA016" modified="2009-09-22" version="1">MKILIVGNGGRESALALKLKADSRISKMYFAKGTVTTAKLGQNIYEDSVEALRDFAIKERIDLTIVGPEAPLVEGIVDEFQKHNLKIFGPEKRAAELEGSKAFSKKFMQSNNIKTAKAVICDSYQEAIDYVRKQQFPVVIKASGLAGGKGVVIAADLAEAESTIHKFMIQRIYGDAGIQLVIEEYLKGFEASIIAFSNGTKIFPCIAAKDYKKAGNADKGPNTGGMGSVAPSPEFTVEHQQDFETNILNPTLVGLNAANIRFKGFIFFGLMVTEKGTYLLEYNMRMGDPETQVILPLMENSLFDVISDCLEGRDVTLKFKDQKAVCLVMCSGGYPGKIETGFEIRNLEKVKDSDVLFAAARTVGDKIVTSGGRVLSVVATADTFADARKKVYEDAKTISFDYEFYREDIGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N9</accession>
    <name>C6X3N9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GldJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782174.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00569"/>
    <dbReference type="EnsemblBacteria" id="ACU07027">
        <property type="protein sequence ID" value="ACU07027"/>
        <property type="gene ID" value="FIC_00569"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00569"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_10_0_10"/>
    <dbReference type="OMA" id="MHDWNNT"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019865">
        <property type="entry name" value="Glid_motil-assoc_lipo_GldJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03524">
        <property type="entry name" value="GldJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973668" evidence="1">
        <location>
            <begin position="21"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="534" mass="61110" checksum="BC0CC39EA2FF4CF0" modified="2009-09-22" version="1">MNKLKLFTILAFCSTLILMSCGGGNTKKGGGTKRFTSKSGWKPNDQKGWFFTGKQQKQKGWPGMVYVEGGTFTMGLVKDDVMHDWNNTPRRMQVSSFFIGETEITNYEYREYVTWLKFVFPPSDPSFKEIYKGALPDTLVWNNELSRNDFAETYFRRPEYDYYPVVGVSWLQASRYCDWLTDRANEKALMEQGVISKDFYTNDANNQGANSFNLDKFKANDPELEAYINTQRLQQRSGIKTSNQRILAANRNAAAGVVEKFRLPTEVEWEFAALGMQKEREYNLYKNKEPQIEQLKGAKGRDRGMYLENFKQGRGDYSGVAGWKNDGSPTTADVKQYPSNNLGIFGMFGNVAEWTADIYRPIIDQEGSDFNYYRGNVAQEVVRNEDGTYKKVDAAKYDTLADGRLVYKGLPGQYEREVVADHRNFRDGDFQSSLDAGYGRAEDSTTAGYNMYNSKQKRFIVDERGRVVLQKDPLARTTRISNEVRVIKGGSWLDGAYWLDPGQRRFRDEAKAYGWVGFRVAQDAKSTSKGRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R3</accession>
    <name>C6X3R3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782198.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00596"/>
    <dbReference type="EnsemblBacteria" id="ACU07051">
        <property type="protein sequence ID" value="ACU07051"/>
        <property type="gene ID" value="FIC_00596"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00596"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026626_0_0_10"/>
    <dbReference type="OMA" id="GMVACLW"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017317">
        <property type="entry name" value="Pept_S8_subtilisin_bacteroid-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037903">
        <property type="entry name" value="Subtilisin_rel_GFO_2223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973536" evidence="6">
        <location>
            <begin position="21"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="168"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="8">
        <location>
            <begin position="468"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="535" mass="58159" checksum="0E45EABF7BD8270A" modified="2009-09-22" version="1">MKKLLLVFIFLSFVMTDAQTELVFVFFKDKPNKAAFYANPLTELSQKSLDRRMRLGIALNDQDVPLEASYIQNVRNLGFTVTDYSKWMNGVAVNATAAQIATLQAQTYVQSVERFIKHPDGGKSTVTKRDKFEEFNNTTGKINFNYGIGLSQINQINLRPLHVAGYTGTGVTIAVIDTGFPTVNTGSAYARIRNNGQIKGGYNFINKTADVYSTALNNHGSYCLGVIAGYIQNQYVGSAPDADFYLYATEDAYNEIPEEMIYWTEAAEEADRKGVDVITTSLGYYDFDDPRYNLLYSDMDGQTSFIARTAQIAAEKGIIVLAAAGNEAQNAWQYIVTPGDNAKVFSIGGVTATGASSSFSSYGPNAAGVSKPDASARGTGTAMGYNNGATTSSGTSFATPLAAGGVACLLQAVPEKPLETLKSLLRENASLFPSTTPQMGYGILNFAATLSDAQLAAAEANRKSKIRIYPNPVTADFAIDTTEKIELVEIYDTLGRKVQSLPQGKTYNLRNFGKGIYFVKIKTADNEYIEKLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V3</accession>
    <name>C6X3V3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782237.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00636"/>
    <dbReference type="EnsemblBacteria" id="ACU07091">
        <property type="protein sequence ID" value="ACU07091"/>
        <property type="gene ID" value="FIC_00636"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00636"/>
    <dbReference type="HOGENOM" id="CLU_1658237_0_0_10"/>
    <dbReference type="OMA" id="EYILINM"/>
    <dbReference type="OrthoDB" id="2089822at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="159" mass="18424" checksum="72387E27A23232AA" modified="2009-09-22" version="1">MENRVNTVIKNFADFLNLSNTSLKLVKDNLVADNFADIQNDFYQVNWEILVESAVCIPGEEWLQIYGEGADCNSGSSRVTFPEKLPTHKIICRSEENIIDLLTNKIVDFENYTFNSFAEIPIDENLVTKFNAILLEHNSENEYILINMKKNIYFYKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X405</accession>
    <name>C6X405_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782289.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00688"/>
    <dbReference type="EnsemblBacteria" id="ACU07143">
        <property type="protein sequence ID" value="ACU07143"/>
        <property type="gene ID" value="FIC_00688"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00688"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097451_0_0_10"/>
    <dbReference type="OMA" id="ISCHLYP"/>
    <dbReference type="OrthoDB" id="1346400at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021458">
        <property type="entry name" value="DUF3109"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11307">
        <property type="entry name" value="DUF3109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="194" mass="21920" checksum="F46AD3DE2EAB602D" modified="2009-09-22" version="1">MIQIKDKLISEDIFSEEFVCNLTKCKGACCVAGDVGAPLDKAETVILEKIFDQVKPYLRPEGVAALEQQGTWTIDPSDGDYVTPMVNGEECAYVIFDAKGITKCGIEKAYEDGAVDWQKPISCHLYPIRVNEYSTFTALNYHEWEICAPACTLGKELQVPVYKFLKTPLIRKYGEEFYDTLCDAAEEWNREFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X436</accession>
    <name>C6X436_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YzbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782320.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00719"/>
    <dbReference type="EnsemblBacteria" id="ACU07174">
        <property type="protein sequence ID" value="ACU07174"/>
        <property type="gene ID" value="FIC_00719"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00719"/>
    <dbReference type="eggNOG" id="COG3876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033227_0_0_10"/>
    <dbReference type="OMA" id="YIWTLYD"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="398" mass="45391" checksum="19F01CA4E0D6E466" modified="2009-09-22" version="1">MILKFKIKDLLLTVLIYFGFSQLGFSQNTDKTCFKTGADRPELYLPLLENKTVAVVTNQTGLMKDRTFLVDYLVKNKVKIKTIFAPEHGFRGDADAGEHVKNGVDTRTGIPIVSLYGDNKKPKPEQLKNIDIVLFDIQDVGVRFYTYISTLTYVMEAAAENGVKVIVLDRPNPHDGYIDGPVLKDKWKSFVGMHNIPVVYGLTIGEYGNMVNGEKWLKNGLQPKYTLIPMQNYHKKQRYGVLDKPSPNLPNDQAINLYPSLCFFEGTQVSVGRGTDLPFQIYGSPWTKNLPFKFTPKPTYGAKDPFLNGKLCYGEDLSATPADLRQLDVSWLLKAYKNYKNPVQDFFLKNLFFDKLAGTDELRKQIIAGKSEMEIKNSWKNDLEDFQKIRSRYVLYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X452</accession>
    <name>C6X452_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782336.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00735"/>
    <dbReference type="EnsemblBacteria" id="ACU07190">
        <property type="protein sequence ID" value="ACU07190"/>
        <property type="gene ID" value="FIC_00735"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00735"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_1_1_10"/>
    <dbReference type="OMA" id="GYDITRT"/>
    <dbReference type="OrthoDB" id="1329125at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="381" mass="41719" checksum="0C2AA83FBF02345E" modified="2009-09-22" version="1">MELPVLLIIIIVLALIFDYINGFHDAANSIATIVSTKVLTPFQAVLWAAVWNFAAFFVAMYIIGEFKIGNTIAKTVNEDFINLEVIFAGLVAAISWNLLTWWFGIPSSSSHTLIGGFLGAALMHAFVMDYHHVALANPDFNIWENGKAAMQQVFTQDVVKYEKVIPIFLFIFMAPFIGMLVSIIITLIIVYFAKNSNPRKADKQFKKWQLVSSALFSLGHGLNDAQKVMGIIGAAVIYYHVSMIGGTDEYAMMASADRFKHFTTDYIWVPFVSFLAIGLGTMSGGWKIVKTMGTKITKVTPLEGVSAESAGAITLFITDHLGIPVSTTHTITGAIIGVGLTKRVSAVRWGITVSLLWAWVLTIPISAIVAGITYLVVITVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X455</accession>
    <name>C6X455_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease synthase and sporulation negative regulatory protein pai 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00738"/>
    <dbReference type="EnsemblBacteria" id="ACU07193">
        <property type="protein sequence ID" value="ACU07193"/>
        <property type="gene ID" value="FIC_00738"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00738"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_0_10"/>
    <dbReference type="OMA" id="QFFFVYF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="20238" checksum="15C8401B2EF273E4" modified="2009-09-22" version="1">MMDIDIKEFEADQLELLTQLSRQTFTETFAEHTSPEDLKLFLSDHLTYDLLASETSNPNSKFYFMTVNGKVAGYMKLNIDDAQCEMREIEGMEVERIYILKEFLGRRLGQFLLEKAFSKGREWGKTYVWLGVWEHNMRALAFYKKNGFEVFDQHAFPVGNDPQIDLMMRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A0</accession>
    <name>C6X4A0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782384.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00785"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07238">
        <property type="protein sequence ID" value="ACU07238"/>
        <property type="gene ID" value="FIC_00785"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00785"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_4_0_10"/>
    <dbReference type="OMA" id="AHMEEID"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="321" mass="36984" checksum="889642777B98ADDB" modified="2009-09-22" version="1">MKTAIALLNWNGKNWLQKFLPGVVLHSPEADIYVIDNASTDGSVDFVRTNFPEVRIIENKENHGFAAGYNEGLRNIEADIFCLLNTDVEVTENWLTPVLGLFERNPDIAAIQPKILDYNRRNYFEFAGAAGGFIDNLGYPYCRGRMFEQIEQDFGQYDDESEIFWASGCGLFIRANDYWAQNGFDERFFAHQEEIDLCWRLKNSGKKIFYTSKSTVYHVGGGTLNKQSPRKTFLNIRNNCSMLVKNLPVSAIVWVLLCRLILDGLAAVHFGFKMGFAHFWAVAQAHFSFYKQIPGTVARRQKQQINHYYGQKWIIFKHFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B8</accession>
    <name>C6X4B8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, contains double-stranded beta-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00803"/>
    <dbReference type="EnsemblBacteria" id="ACU07256">
        <property type="protein sequence ID" value="ACU07256"/>
        <property type="gene ID" value="FIC_00803"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00803"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1479969_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="182" mass="20141" checksum="D630382F064326D2" modified="2009-09-22" version="1">MIQTRKQFLSTASISMFGLMIAPNLLSNEISDGKPVIMHADEGETYWIGMRNSPLTIKIAKDHGNNTSMSLCTELIAPAEDVPVHKHLNEDELIFIHTGEGMLTVGDDDIPVRKGSVALIPKGIWHGLKNIGSDPLLMVFSYSPAGFEGYFRELGSPAGTPWQPKSKEAFEKLDKKWGIVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C2</accession>
    <name>C6X4C2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-binding proteins-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00807"/>
    <dbReference type="EnsemblBacteria" id="ACU07260">
        <property type="protein sequence ID" value="ACU07260"/>
        <property type="gene ID" value="FIC_00807"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00807"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249083_0_0_10"/>
    <dbReference type="OMA" id="YLEAMIL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="25197" checksum="2F40A66B422E2BF4" modified="2009-09-22" version="1">MHYLEAMILHESYLANPMFDNLSDREKAVLASNASLVNFEQEEMFLKQGSLLNSVYFIYSGVVKLKYSNNKLFQLLGAGDFIGLLYLYSHDPAFFSAFGIGGSEIIQFEKNVFKKFVSTNSKFLVDVYNKSTANSISLTQNIISYKDHKINGALADFLLHFDGKNCLHSLKQKEISELVGYSRENVCKCMNEFIREGFIEYQNESVKLLNVQALRTLKQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D0</accession>
    <name>C6X4D0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782414.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00815"/>
    <dbReference type="EnsemblBacteria" id="ACU07268">
        <property type="protein sequence ID" value="ACU07268"/>
        <property type="gene ID" value="FIC_00815"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00815"/>
    <dbReference type="eggNOG" id="COG1912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_1_1_10"/>
    <dbReference type="OMA" id="EIPYQKA"/>
    <dbReference type="OrthoDB" id="1262717at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="275" mass="31205" checksum="D99727C381894890" modified="2009-09-22" version="1">MSVITFTSDYGLVDHRVPAVKGKILSLNENATIVDISHEIQAYNLLQTAYIVRNAYPFFPKGTVHIISVDSFFTKARKSVLYEADGHYFIAADNGLLSLIFFDIKPDAVYELTFNNRFDDEVRFTSTDIFAPAAVHLQNGGLPEVIGRKFKTPKELQVQRAVFNENEKMIIGEIMYIDNFGNAVSNINRKFFEKCSVGFEHFILKFRNLALSKIYNQYTEFVTDWSAEHEYHGKSAAIFNDAGLLELTIYKGNSQNGAKTLFGLKVGESIYIEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D6</accession>
    <name>C6X4D6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="9" type="ordered locus">FIC_00821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782420.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00821"/>
    <dbReference type="EnsemblBacteria" id="ACU07274">
        <property type="protein sequence ID" value="ACU07274"/>
        <property type="gene ID" value="FIC_00821"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00821"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_10"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="455" mass="50393" checksum="3B445AE5343F30C7" modified="2009-09-22" version="1">MFNSLQDKLDKALHNISGRGKITEINVAETVKEIRRALVDADVNYKVAKDLTKRVQDKALGQNVLTSLSPGQLMTKIVHDELVDLMGKTHEGINLSGKPSVILIAGLQGSGKTTFSGKLANYLKEKRNKKPLLVACDVYRPAAIEQLKILGQQTGIPVYTEEGALNPSSIAENAVKFAKENNHDVVIVDTAGRLAIDEQMMNEIKSVHYFIKPNETLFVVDSMTGQDAVNTAKAFNEALNFDGVVLTKLDGDTRGGAALTIRSVVEKPIKFISTGEKMEALDVFYPERMADRILGMGDVVSLVERAQEQFDEEEAKKLHKKIAKNEFGFDDFLKQINQIKKMGNMKDLMGMIPGVGKAIKDVDIQDDAFKHIEAIIHSMTPDERRRPSIINTQRKNRIARGAGRKIEDVNALMKQFEQMGKMMKMMQGPQGKQMMEMMSKGMPKVPGMGGSPFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F3</accession>
    <name>C6X4F3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782437.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00838"/>
    <dbReference type="CAZy" id="GT32">
        <property type="family name" value="Glycosyltransferase Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07291">
        <property type="protein sequence ID" value="ACU07291"/>
        <property type="gene ID" value="FIC_00838"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00838"/>
    <dbReference type="eggNOG" id="COG3774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085669_0_0_10"/>
    <dbReference type="OMA" id="VIWQTNY"/>
    <dbReference type="OrthoDB" id="797299at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="PTHR31834"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="222" mass="26640" checksum="0816DB164427546E" modified="2009-09-22" version="1">MAIPKNIFQTFKTKKLPLITRWHIWNIKRQNPEYQYYLYDDDDVQEFFRKEFPEEYLKAYKRLTIGAAKADFFRYAILYRKGGVYLDVDSGISKPLRKLIRPDDVAVLSRERHVHFYCQWALIFDKEHPFLKKTLEMVLDNIQTHRFPHNVHSTTGPAVFSDAVNACIAEDPNIPYRLFEGIEYRGYLKFKYKLGKFFLYSKKSEHWKRKQLTQDIIKPADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4G2</accession>
    <name>C6X4G2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ordered locus">FIC_00847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782446.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00847"/>
    <dbReference type="EnsemblBacteria" id="ACU07300">
        <property type="protein sequence ID" value="ACU07300"/>
        <property type="gene ID" value="FIC_00847"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00847"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_10"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="OrthoDB" id="1522718at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="27274" checksum="F7048AADB865121B" modified="2009-09-22" version="1">MLKKRIIPCLDIKDGKTVKGVQFEGLRFAGDPIELAKKYVADGADELVFLDITATLEGRKTLVELVRKLSKEIDIPFTIGGGISSVEDVELLLRAGADKVSINSAAVRRPKLIRELAQNFGSQCVVVAVDTKQTPDDDFVFVNGGKIQTELKTLEWIRQLTDLGAGEILLTSMDYDGTKSGFDLRMLNTVTEISPLPVIASGGAGSLQHFSSLFLETRVSGALAASVFHFNEINIKDLKSNLKLNKIPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I9</accession>
    <name>C6X4I9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782473.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00874"/>
    <dbReference type="EnsemblBacteria" id="ACU07327">
        <property type="protein sequence ID" value="ACU07327"/>
        <property type="gene ID" value="FIC_00874"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00874"/>
    <dbReference type="eggNOG" id="ENOG5032UKD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228419_0_0_10"/>
    <dbReference type="OrthoDB" id="1867043at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973578" evidence="1">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="26788" checksum="2BCC5BBB1CEE87B5" modified="2009-09-22" version="1">MKTSIKIKLTMLFLLSANFTFSQEAIEDSLISRMCEDLPTYKKLDKREIGPTIFDKHLTKYLETKKLSKRDSISISIDQRLQRKCPDYIKILDKIHKPKRGNWTYLKNIPKSRITDKQIDEFKNTQSFYYIKKSGSEVPVKIENNQWIDLLPNNTYSKLDLEWLTNTSFQLKFIESNNLHHKGSSRKGDIYKYDIIERKKNYYLLVLTTPQNNRIVSFKFYPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K8</accession>
    <name>C6X4K8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782492.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07346">
        <property type="protein sequence ID" value="ACU07346"/>
        <property type="gene ID" value="FIC_00894"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00894"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_6_4_10"/>
    <dbReference type="OrthoDB" id="1718602at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="210" mass="23856" checksum="2980B53013E4A539" modified="2009-09-22" version="1">MCNRVDNYGISIEKVSQQLEAEIAEGNYFFANEVNAFDRPALPIVLDHHGRKITHGTWGLIKEIQKDRPAQGINLTAEKAGTLYREYEHNRCVIPVAGFYDWMHVSDPGKKTALKIKHRMHLKGENTFYIAGFYNVWNNYEIGFGVVTTAANKLMSVIHNSKSRMPVCLDAEMANRFLNDEPIELFTYPTHDPALVALNLEASKMPPTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W6</accession>
    <name>C6X4W6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tal</name>
        <name evidence="10" type="ordered locus">FIC_01004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01004"/>
    <dbReference type="EnsemblBacteria" id="ACU07454">
        <property type="protein sequence ID" value="ACU07454"/>
        <property type="gene ID" value="FIC_01004"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01004"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_0_0_10"/>
    <dbReference type="OMA" id="QQMLGTP"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="242" mass="26472" checksum="828FEAA7A6027E86" modified="2009-09-22" version="1">MYFLLTINRFHNTAENLTFVKITINMKFFIDTANLDQIREAQDLGILDGVTTNPTLMAKEGISGKEAILNHYKTICEIAEGDISAEVLSTTYEEMIAEGDELAAIHPNIVVKIPMIKDGIKALKYFSDKGIKTNCTLIFSAGQALLAAKAGATYVSPFLGRLDDISVDGLNLIEEIRIIFDNYMFDTEILAASIRSPMHIINCAKIGADVITSPLVSILNLLKHPLTDSGLAQFVADAEKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y7</accession>
    <name>C6X4Y7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4435 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782621.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07475">
        <property type="protein sequence ID" value="ACU07475"/>
        <property type="gene ID" value="FIC_01025"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01025"/>
    <dbReference type="eggNOG" id="ENOG503342K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097160_0_0_10"/>
    <dbReference type="OMA" id="SHASIAW"/>
    <dbReference type="OrthoDB" id="1844807at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029492">
        <property type="entry name" value="DUF4435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14491">
        <property type="entry name" value="DUF4435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4435" evidence="1">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="252" mass="29339" checksum="7EBD79E1F0FC68A0" modified="2009-09-22" version="1">MIKENSMTLELTVDEIIATLQRTSLITVLVEGTDDVMIYRWIEDEIGVLNANFMPCGGRKKLIEIFERRSEFSGSKVIFVADKDSYIYTKVPEEYDEIIWTNGYSIENDLYYGKDIEKILSKSEKEIFVKSMDSFIKYYSFEVEKMLSGNPDFTLRAHPQHILCDLQNLVKEEYLKSVNFIEPSSAIVTMITENYDVMIRGKSLFALLTRILSHKDREIKHSKASLLEHCYRTHRSVKFTELLDKINKKISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X514</accession>
    <name>C6X514_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein containing DUF1015</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805787.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01052"/>
    <dbReference type="EnsemblBacteria" id="ACU07502">
        <property type="protein sequence ID" value="ACU07502"/>
        <property type="gene ID" value="FIC_01052"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01052"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031277_0_0_10"/>
    <dbReference type="OMA" id="IYIADGH"/>
    <dbReference type="OrthoDB" id="591335at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="414" mass="48425" checksum="6AF60362061B7BE4" modified="2009-09-22" version="1">MPTFKPFRGIRPSEDFVNVFPTHPLDNFSQDEINKKAQLESSYIQMIKPYVVSKSKDLDRNLRKIRSNYEELLEDKKLVQDPSAYYLYEQVLPNKTVYRGLLGLVSVDDFRNGKIKKHESTLTQKKEKLAYYLEKVNIQAEPVLLTYMANPKVELLMNHEEKNVPVLNYLDDSKVRHKVWRIDNRLKMQQFKEVLEQIDSFYIADGHHRIGSTALNAEHLREKNKKHTGTELYNYVFSFVVSNQSIRIHDYNRLLQDLNGLSEGEFLNKIGENFLVHEKGTTPYYPSQKFHISMYLGGKFYSLHVKHELRKQQSAMNDLDHFLLEEFVFKDILGIEDPKTTDKITYIKGDSSVEGINQIKEKVDSENYKVGFGIYPVSFNDLLKVSDKNIKMPPKCTYIEPKLVTALVMYDMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X533</accession>
    <name>C6X533_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805806.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01071"/>
    <dbReference type="EnsemblBacteria" id="ACU07521">
        <property type="protein sequence ID" value="ACU07521"/>
        <property type="gene ID" value="FIC_01071"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01071"/>
    <dbReference type="eggNOG" id="COG2351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115536_1_0_10"/>
    <dbReference type="OMA" id="ENQNYHI"/>
    <dbReference type="OrthoDB" id="1955791at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970686" description="5-hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="TR_THY" evidence="9">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="132" mass="15070" checksum="9A4FDB4CFC2BE9AF" modified="2009-09-22" version="1">MKKMFFTAFFAVLSVCAFGQTNTYQLSSHILDVSEGKPASGVNIRLELYSSGVWSLVDEKTTDKNGRITDFLPGNKSTGIYKLTYLVSDYFKRTNKETFYPFIEVVFQIKDDQHYHVPITLSAYGYSTYRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X557</accession>
    <name>C6X557_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07545">
        <property type="protein sequence ID" value="ACU07545"/>
        <property type="gene ID" value="FIC_01095"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01095"/>
    <dbReference type="eggNOG" id="ENOG50331M8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088492_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="266" mass="31474" checksum="CCA3E5FF8E6960CF" modified="2009-09-22" version="1">MKMAEKIFHYCTIDTLEKILTNKTIRFSRFDLMDDQTETDGLPEMLKKNYFLSCWVSDRKEKIPQWAMYAPRGVRIELPIKWYKKFPIPVVGTDQFIEKIPVDDDHPGRNTFFPKPFKEWFLASQGFYFVPPLDEEDGFVTKVIYSENFSKLKQQHWKANEDGTSISLAHQAAPIKFKDDYWSFQDEVRFYLTAGCRHEDRHLLPDYIDLPVDEQALKKIKIRLYPNCKSEDWKAVKNLISDKFSTLDSKDIIEKSDLEGKYFPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X590</accession>
    <name>C6X590_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805863.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01128"/>
    <dbReference type="EnsemblBacteria" id="ACU07578">
        <property type="protein sequence ID" value="ACU07578"/>
        <property type="gene ID" value="FIC_01128"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01128"/>
    <dbReference type="eggNOG" id="ENOG503397B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166722_0_0_10"/>
    <dbReference type="OMA" id="DRITVHE"/>
    <dbReference type="OrthoDB" id="1788141at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="119" mass="13639" checksum="02B0B85E010E1987" modified="2009-09-22" version="1">MNTHQAAADITATLPELTHEVSRSINLQNPFALIRILTRYTQKMVQQHNTAMAEKCMTLIGRIYTKGDLMIKHAVEDVFVFSMDRITISCTLSERNHLVKNIPAPLYRVYLKQVYKSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5A1</accession>
    <name>C6X5A1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805874.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01139"/>
    <dbReference type="EnsemblBacteria" id="ACU07589">
        <property type="protein sequence ID" value="ACU07589"/>
        <property type="gene ID" value="FIC_01139"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01139"/>
    <dbReference type="eggNOG" id="ENOG502ZRDR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692893_0_0_10"/>
    <dbReference type="OMA" id="QAWINED"/>
    <dbReference type="OrthoDB" id="2074927at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="155" mass="17792" checksum="ED97434D60B5EAB6" modified="2009-09-22" version="1">MEENIVEFWINSDSQLSKILTDIESETEVLESQADKAFHKVAEEYNLPKMPNDIDYDDENYDDEIKSVYEVLGLIKYAYPDEDPRGNVMLALTCVKDNIPFDIENVLSEAEKQEIDTSQISGICYTGTNYNVEIKFIINGENWADSNCNLFLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C2</accession>
    <name>C6X5C2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01160"/>
    <dbReference type="EnsemblBacteria" id="ACU07610">
        <property type="protein sequence ID" value="ACU07610"/>
        <property type="gene ID" value="FIC_01160"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01160"/>
    <dbReference type="eggNOG" id="ENOG50332TS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083023_2_0_10"/>
    <dbReference type="OMA" id="REYEIAW"/>
    <dbReference type="OrthoDB" id="1812714at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="129" mass="14897" checksum="7D19844891A664CA" modified="2009-09-22" version="1">MAVVCPECDRLALATVDYDTQEARLVCADCGYSKTSSTKLVIAGIRADAHVAAHEYFNAELWYQLPFRDAFFVAYNKEHLLYLESYISAGLREHKDRTHFTLLEKLPRFYHEAKNREALLKLIAKLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C6</accession>
    <name>C6X5C6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase, probable oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01164"/>
    <dbReference type="EnsemblBacteria" id="ACU07614">
        <property type="protein sequence ID" value="ACU07614"/>
        <property type="gene ID" value="FIC_01164"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01164"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_1_10"/>
    <dbReference type="OMA" id="AAYQMSQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="298" mass="32450" checksum="C5B3D122673960F0" modified="2009-09-22" version="1">MVIYQKQKIKPSAMQKDSKKEIRPRQSQAKPGLEKDLKPKPDSQPSAQTLKLEGKTALITGGDSGIGKATAILFAQHGADVAIAYLNETADAKETQKEVEKLGRKCFLIKGDLGNEKHCKKVVEKTVDNFGKIDILVNNAATHWEAETIEDISTDQMMKTFHSNFFSIFWVTKFAMKHLKKGSTIINTTSVTAFRGSDHLLDYAATKGAVLSFTRSLSANLAEKEIRVNAVAPGPIWTPLIASTFSKKEVAKFGSDVPMGRAGQPSEVATCFLFLASEDSSYMTGQVLHPNGGEIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H9</accession>
    <name>C6X5H9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805952.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01219"/>
    <dbReference type="EnsemblBacteria" id="ACU07667">
        <property type="protein sequence ID" value="ACU07667"/>
        <property type="gene ID" value="FIC_01219"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01219"/>
    <dbReference type="eggNOG" id="ENOG5033P46">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432610_0_0_10"/>
    <dbReference type="OrthoDB" id="2121090at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="189" mass="22430" checksum="CCFEDAA066EB6586" modified="2009-09-22" version="1">MKSKLLFILSLFIFYACSVNKNSAIPVQSEIDLSLKNFAEIKKEEINKKSKDISLGYFWGIGEGIYPTFANHKFEIPKSYQRPENNFILKVDYFFTEDNQTKFKMYEWNDIEKKETLNNQFNSKFEDIKNYITKNIGKPNSELYEDLEKSDEQTVRDEIKWKSQNLNAYLFRFKGKGGFNQIRLAIYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L7</accession>
    <name>C6X5L7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805990.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01257"/>
    <dbReference type="EnsemblBacteria" id="ACU07705">
        <property type="protein sequence ID" value="ACU07705"/>
        <property type="gene ID" value="FIC_01257"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01257"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402161_0_0_10"/>
    <dbReference type="OMA" id="HINHIAI"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973486" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="690"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="755" mass="82309" checksum="A0D7E4BD173D9755" modified="2009-09-22" version="1">MKKITILISAVLLGAAHLVPAQLSVVGSQNFGRMFDLTYDQKKANTIYAITMKNHIVVSRDNGVSWEVFYAMPASIGSRLSQLKISADGSELTFAVDGSNAAVIVLNIAAEKITKQFALPNAADNPQVKAYSFLPGDSSILLVNTEWQVGVDNYGKAFYTKTGGSTWTEIYDTELNDKVFINAISVSPDNSNRIYLLRGNGSMDVIGGLLISDDSGASYREELEGITLSSIAFPPNTSNELYIGTAITFSGTPEALYHSTDGGTTFTTAPVAWNNTGNTNHINHIAINPLNNYVYVLEEDEVAISKDNGATWTKKEYELDNLTDYYYGLTMSFNPFDASELVLGQNFTPALSKDGGETFQLIRSPYFNSDARVEMAENATAKHLYYGVQYGFVHKNLTTGEENARDIKALTAFGTFGSSKIFTDPKTEGRIFKYNATSMGATLRMSNDYGQTFQVIVSNSSNQMLDLKTDPVNPNKIWASFAQYSEGELVTIDFSDPDVTVTPVSIPTTQPVTQILHTDATSAELLIASGSELYKTTDGGANWLNVPLAGATPDFISDIAQNPLQRNELALATSNGVYTSINSGQTWSQTQSPEVKMVQYSDTVSGHMIAANYVSDYSTFALLYSSDHGATWTQVDADDLWNVESASIYADFTGNTAKVYIATFDLGIVTYELTFANLGAGNTVKSDITVYPNPTSDYLYIGSDILSATLYDFSGRKVADSKVPKINISHLNNGAYLLKIITADRKEVTRKIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T0</accession>
    <name>C6X5T0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-54 dependent transcriptional regulator/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806053.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01320"/>
    <dbReference type="EnsemblBacteria" id="ACU07768">
        <property type="protein sequence ID" value="ACU07768"/>
        <property type="gene ID" value="FIC_01320"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01320"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_10"/>
    <dbReference type="OMA" id="DWTGNIR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="148"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="394" mass="43717" checksum="EC08B2A445524AFB" modified="2009-09-22" version="1">MQKILIVEDEKAISGVLQSILSDELPEYEFFIAEDGLDGLKQIEKEDFALVVSDIKMPKLSGTELLKQALQIKPETTFVMISGHADIDTAVACLKEGAYDFISKPVDINRLITSVKNALDKRILQKTNQVLNVENSTLKKKVNKKFQMIGQSPALKKIQDMIEKVAASDARVLITGPNGAGKELVAHAIHAQSDRSRGPMIEVNCAAIPSELIESELFGHVKGSFTGAIKDKQGKFELATNGTIFLDEIGDMSLVAQAKVLRALQESKVSPVGSDKEIKVDVRILAATNKNMQKEIEAGKFREDLYHRLSVIEIYVPPLDERKEDIRLLVEHFSKIISEEHGTAQKSFDENAIKALENFAWTGNIRELRNVVERLIILGSNPVSETDVANFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V5</accession>
    <name>C6X5V5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01345"/>
    <dbReference type="EnsemblBacteria" id="ACU07793">
        <property type="protein sequence ID" value="ACU07793"/>
        <property type="gene ID" value="FIC_01345"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01345"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_10"/>
    <dbReference type="OMA" id="SVAMTGW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="412" mass="46071" checksum="81D856689C286900" modified="2009-09-22" version="1">MQKKIIFGNLRFIMEKHADRLSRMSFSQTFVMSNKVREMKANGIDVISLTLGEPDFDVPANIKEAAFDAINSNFSHYSPVPGFLDLRQAICDKLKRDNNLSYLPSQICVSNGAKQSILNVLASLLNDGDEVILPAPFWVSYNEMVKMMGGQPVIIETSIETDFKMTAEQLENAITPKTKILLYSSPCNPSGSFYTYEELEKIADVVAKYPQITIISDEIYEYINYDGKHTSIAEFPQVYEQTAVINGMSKAFAMTGWRIGYSACPTWLATGCEKIQGQMTSGANTMAQKASVTALQTDPSEYRYMIDKFAERRELVYGLMKEIPGFSVNYPEAAFYFFPDISYYIGKSLNGKTIGDADDFAMFLLENAHVGSVGGVSFGNPNCIRFSYAASEKDLTEAMRRIKDCLENATYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y8</accession>
    <name>C6X5Y8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806111.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01378"/>
    <dbReference type="EnsemblBacteria" id="ACU07826">
        <property type="protein sequence ID" value="ACU07826"/>
        <property type="gene ID" value="FIC_01378"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01378"/>
    <dbReference type="eggNOG" id="ENOG5033KIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335872_0_0_10"/>
    <dbReference type="OrthoDB" id="1274454at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="205" mass="23977" checksum="3B18F7C220CECAF1" modified="2009-09-22" version="1">MNNLAKNNRFLPIIGIVLILIGYFYLTYETFKLNEKRDLLQTDIARFTKEIAKLEAIKARLTTEIKAADSIRKIQNTIILKSADPQTVQKGIELNKKITNPESTFFTRTNADQTNLQLATQFEAEGYRYLFARDVENAIKAFIKSENSYNSFHQVYEISNYLTLNKKKLAVKDSPFWKEAYREIYTQFSWKMPENIQTQLKDHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X602</accession>
    <name>C6X602_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01392"/>
    <dbReference type="EnsemblBacteria" id="ACU07840">
        <property type="protein sequence ID" value="ACU07840"/>
        <property type="gene ID" value="FIC_01392"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01392"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_11_0_10"/>
    <dbReference type="OMA" id="YKQAFGA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="139" mass="15625" checksum="E50C1BA999F3C34E" modified="2009-09-22" version="1">MAAVRRILPKALNNSPSLSFKLKNLKMETSFKPTGYTSLSPYLIVENAQKLTELLKKVFNATELRTFIRGDGSVQHSELQLDDSVIMISDSLDEYPPITAMLHYYVQDVFKTFELAIKNGCEVIEQPKKGDDGDTRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X624</accession>
    <name>C6X624_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806147.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01414"/>
    <dbReference type="EnsemblBacteria" id="ACU07862">
        <property type="protein sequence ID" value="ACU07862"/>
        <property type="gene ID" value="FIC_01414"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01414"/>
    <dbReference type="eggNOG" id="ENOG502ZRUR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142853_0_0_10"/>
    <dbReference type="OMA" id="QYTHINH"/>
    <dbReference type="OrthoDB" id="1724320at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011463">
        <property type="entry name" value="DUF1569"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07606">
        <property type="entry name" value="DUF1569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="152" mass="17550" checksum="ABBC47EE98C76BB7" modified="2009-09-22" version="1">MRKSLNDPDDVAALKQRLLNITETTERKWGRMNSAQMLCHCDKILQVGIGKIVLPRTNFLIRTIGVCAKIEMKIFSNGIPPNMPTFEVVKLKENCKFEESRDHLFATLDEFVKCLEQDNLLAEHVLFGKMSRHDWGSLQYTHINHHLNQFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X649</accession>
    <name>C6X649_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">menA</name>
        <name evidence="7" type="ordered locus">FIC_01439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806172.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01439"/>
    <dbReference type="EnsemblBacteria" id="ACU07887">
        <property type="protein sequence ID" value="ACU07887"/>
        <property type="gene ID" value="FIC_01439"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01439"/>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_1_1_10"/>
    <dbReference type="OMA" id="QWIEGAR"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="309" mass="34974" checksum="7CE25F0258DAEAF1" modified="2009-09-22" version="1">MNIWIQAARLRTLPLSISGIIMGSFIARWRITEEGGTWDWKIFALALLVTLLYQVLSNFANDYGDGIKGTDKLRINEAEQRAVASGKITANQMRNAVILFAVLSLIATVALLYLAFFRENLMQEFYTFVGLGIACILAAIGYTVGKKPYGYMGLGDIFVFVFFGLVSVCGSYFLFTKTFHWDILIPATAIGMMSVGVLNLNNMRDIENDTLSGKKTLAARMGYRYAMVYEIVLLQLPLILMLVFMMMNKLHEQGNYYAFIFFILVFPMTALRRKIMQTKEPKELDPYLKQVGIFTLVMSVLVAFGLNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X685</accession>
    <name>C6X685_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806208.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01475"/>
    <dbReference type="EnsemblBacteria" id="ACU07923">
        <property type="protein sequence ID" value="ACU07923"/>
        <property type="gene ID" value="FIC_01475"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01475"/>
    <dbReference type="eggNOG" id="ENOG502ZBR4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116186_1_0_10"/>
    <dbReference type="OMA" id="PEIGYHN"/>
    <dbReference type="OrthoDB" id="1756436at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973501" evidence="1">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="19844" checksum="5103EEE0AFE29D52" modified="2009-09-22" version="1">MKSMKKTILALGVMTAGLVSAQSADMRNMLKVGINGGIAVPAENAGGTVGVDVSYQNLVTPGFGLGIATGYSHFFGSENDGINNNDFGVVPVAALIRVYPKQMGFYLGTDIGYGFIVGDDQVAENSTVERPDGGFYIKPEIGYHNKDWNFSLQYQKTFTGDKGEILDQKYNAGAIGVGVGYNIPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A1</accession>
    <name>C6X6A1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="13" type="ordered locus">FIC_01492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806224.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01492"/>
    <dbReference type="EnsemblBacteria" id="ACU07939">
        <property type="protein sequence ID" value="ACU07939"/>
        <property type="gene ID" value="FIC_01492"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01492"/>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_10"/>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="57"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="393" mass="42702" checksum="269C34AAEA59F6F1" modified="2009-09-22" version="1">MENYKNPDVHGYYGEFGGAFIPEMLYPNVAELKEKYIEIIESAEFQEEFQDLLKNYVGRATPLYLAKNLSQKYYTQIYLKREDLNHTGAHKINNALGQALVAKKLGKRRIIAETGAGQHGVATATACALLGLECIVYMGEVDIARQAPNVARMKMLGATIIPAVSGSKTLKDAVNEALRDWINNPTTTHYIIGSVVGPHPFPDLVARFQSVISEEIKWQLNEKIGRQNPDYVMACVGGGSNAAGAFYHFVDEPDVKIIAAEAGGFGVASGKSAATTFLGTLGVLHGSKSLVMQTADGQVIEPHSISAGLDYPGIGPFHANLFKEKRAEFVSVTDEEALEAAMELTKLEGIIPALESAHALALLKKKTFAEDDVVVICLSGRGDKDMETYLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C9</accession>
    <name>C6X6C9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin-dependent glutamate synthase</fullName>
            <ecNumber evidence="5">1.4.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806252.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01520"/>
    <dbReference type="EnsemblBacteria" id="ACU07967">
        <property type="protein sequence ID" value="ACU07967"/>
        <property type="gene ID" value="FIC_01520"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01520"/>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026563_1_0_10"/>
    <dbReference type="OMA" id="QYFFAMD"/>
    <dbReference type="OrthoDB" id="151647at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_synthase" evidence="4">
        <location>
            <begin position="147"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="506" mass="56537" checksum="80F721E98F75033E" modified="2009-09-22" version="1">MRDKFIKYGIVIVIAVWAISLLIRAHYWIPILLTCIYALGIYNCFQTKHAILRNFPVLGYFRYFFESISPEMQQYFIERETDGKPFPRNQRSAVYRRSKNISDTVPFGTQLEINQRKYEGIKHSIYAKSPNEELPKVWIGGEQCTQKYHASLFNISAMSFGSLSDRAQMALNRGAKKGQFYHNTGEGGISPYHLEGGDLCWQIGTGYFGCRDDDGRFSPEIFKKNVSLPNVKLIEIKLSQGAKPGHGGVLPAAKNTPEIAAIRHVRPGLTIISPPSHSAFSDAAGLLKFVQQLRELSDGKPVGFKLCIGDTKEFEDICVQMNVLRIYPDFITIDGAEGGTGAAPPEFSDGVGMPLEPALIFVNRTLKDFNLRDKVKIIASGKVLTSLDILRAVAMGADMCNNARGFMFALGCIQALRCNTNNCPTGVATQDKMLIKGLDVTDKSERVYHFHKNTLRTCNELIASAGRSSYEEVDATMFMRGDEFEHLSDIYFPDILGNVKDKLTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB1</accession>
    <name>C6WZB1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ordered locus">FIC_00521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782126.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00521"/>
    <dbReference type="EnsemblBacteria" id="ACU06979">
        <property type="protein sequence ID" value="ACU06979"/>
        <property type="gene ID" value="FIC_00521"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00521"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_10"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="281"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="359" mass="39451" checksum="0B36B14C0FDD798F" modified="2009-09-22" version="1">MNRTALFDKHVALGAKIVPFAGFDMPVQYTGVTEEHMAVREKVGIFDVSHMGQFWVEGPTAKDLLQYVTTNNVDSLETGKAQYTCLPNGNGGIVDDLIIYKMSDEKYFVVVNASNIEKDWNHITKYNEKFGAKLTNVSDELSLIAVQGPKASETLQKLTETNLAELPYYHFTQGSVASVADVIISNTGYTGSGGFEIYFKNENAVAIWEALTAAGEKFGLLPCGLAARDTLRLEKGFCLYGNDIDDTTSPLEAGLGWITKFDKDFVDKEFFAKQKEEGVTRKLVGFEMQERAIPRHGYAVVDAEGNEIGTVTSGTMSPMKNIGIGLGYVAKSHLKVGSEIFIKIRNKNVPAQVVKLPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ4</accession>
    <name>C6WZJ4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster assembly ATPase protein SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781676.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00053"/>
    <dbReference type="EnsemblBacteria" id="ACU06529">
        <property type="protein sequence ID" value="ACU06529"/>
        <property type="gene ID" value="FIC_00053"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00053"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_10"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="247" mass="27479" checksum="0FA5279902E726E6" modified="2009-09-22" version="1">MLHINNLHAQIESGVEILKGINLQINPGEVHAIMGPNGAGKSTLSSVIAGKEEYEITEGDIFFNGQNIIEDAPEDRAHKGIFMSFQYPVEIPGVSVTNFIKAALNETRKANGLEDMPAREMLALIRENSEKLGIKRDFLSRSLNEGFSGGEKKRNEIFQMMMLNPKLAILDETDSGLDIDALRIVADGVNSFRNEGNAVLLITHYQRLLDYIQPDFVHVLADGKIIKTGDKTLALELEERGYDWLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK7</accession>
    <name>C6WZK7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781689.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00066"/>
    <dbReference type="EnsemblBacteria" id="ACU06542">
        <property type="protein sequence ID" value="ACU06542"/>
        <property type="gene ID" value="FIC_00066"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00066"/>
    <dbReference type="eggNOG" id="ENOG502Z7MQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080414_0_0_10"/>
    <dbReference type="OMA" id="YNYHRKG"/>
    <dbReference type="OrthoDB" id="1502697at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032274">
        <property type="entry name" value="DUF4835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16119">
        <property type="entry name" value="DUF4835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="301" mass="34593" checksum="6CA2875BDFC2D7E9" modified="2009-09-22" version="1">MKKIFTIFVLVFTIQLGYAQELLATVQVNAQQLGGSNTQVYKTLEKNLRDFINNTSWTGKKLQNFEKIKCNFSIVINERSGSNNFKGSLVVQAVRPVFNTTYESPLININDTNFSFDYTENENLVFNERQFSGKNLIDVVSFYIYTILGYDGDSFKVRGGQPWFEKAQKISNNSQNQSFAGWSVMEGTRTRGALIDNILKTEQNTLRNIYYTYHRAGLDNMGKQDQASGKRIIAEALLQLKTYENNFQMNYPINLFIDTKKQEIFDIFSNGNNANVNMADLKALFVTLAPREIDSKWNKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN8</accession>
    <name>C6WZN8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00098"/>
    <dbReference type="EnsemblBacteria" id="ACU06573">
        <property type="protein sequence ID" value="ACU06573"/>
        <property type="gene ID" value="FIC_00098"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00098"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_3_2_10"/>
    <dbReference type="OMA" id="FGGCPMA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="293" mass="33298" checksum="12645C804FE03D00" modified="2009-09-22" version="1">MFIFEKTQYLKMFLTECPRDAMQGWGEFIPTNKKIDYINSLIDVGFDVLDCGSFVSPKSIPQMADSGTVVDEIDKGISNTKLSVIVANFRGAEKALQHQQIDILGFPFSISETFQHRNTNKGQEAAFEDIVKILQLVEADGRKLNIYFSMAFGNPYGEMWKWEDVDFWAQRFSDIGIKNILLSDTTGTGTVEQIELLFSKIPAKYPDIDFGAHFHNRYEDSYIKLKAAYDNGCRRFDSAIKGIGGCPMAKDDLVGNMPTEQVINFMASEKIQHKLNLLHFESAYNQAKKIFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZS4</accession>
    <name>C6WZS4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00134"/>
    <dbReference type="EnsemblBacteria" id="ACU06609">
        <property type="protein sequence ID" value="ACU06609"/>
        <property type="gene ID" value="FIC_00134"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00134"/>
    <dbReference type="HOGENOM" id="CLU_2990089_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="57" mass="6627" checksum="1D3268429475BC84" modified="2009-09-22" version="1">MRKKVNYFLIVAGALLFLLNLWSADFRTEEINFWSAGASILMVVLGFVELRKYNNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT7</accession>
    <name>C6WZT7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00147"/>
    <dbReference type="EnsemblBacteria" id="ACU06622">
        <property type="protein sequence ID" value="ACU06622"/>
        <property type="gene ID" value="FIC_00147"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00147"/>
    <dbReference type="HOGENOM" id="CLU_2450262_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973421" evidence="1">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="89" mass="9933" checksum="3E48EED1735AD8C4" modified="2009-09-22" version="1">MFPFYYSLSSVFLFVKSAVSPVFSASSFMISESSKMRTAGDSSSSNCPFLALTIKMIKKIAATETLQRIIKYKISIFPANLGKNRFKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU8</accession>
    <name>C6WZU8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00158"/>
    <dbReference type="EnsemblBacteria" id="ACU06633">
        <property type="protein sequence ID" value="ACU06633"/>
        <property type="gene ID" value="FIC_00158"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00158"/>
    <dbReference type="eggNOG" id="ENOG5033T08">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188963_0_0_10"/>
    <dbReference type="OMA" id="VAGRMYQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970485" evidence="1">
        <location>
            <begin position="29"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="236" mass="25387" checksum="3E911196430ED5CE" modified="2009-09-22" version="1">MVEQFKLHFMKKLYALAMAFFAIITVSAQLAVQVTAPGVVKLTYGASNDYSIYGPGFEVPTFWIHVWSSAGDNSTGTMYDDSWGNSNVTMNWDATASAYVGTIDLNTKVFTNGNKVFAAGTTVSNLGFVFKNQQNGATQQSGDLLASDFGFTPTTLVVLGTDNTARAKKSFVSNGKLYTSHQGNIALTIFEMSGKLVKSFTSAANGDAIDLNVEKAGLYLVKITRGTETEVVKFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU9</accession>
    <name>C6WZU9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent outer membrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00159"/>
    <dbReference type="EnsemblBacteria" id="ACU06634">
        <property type="protein sequence ID" value="ACU06634"/>
        <property type="gene ID" value="FIC_00159"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00159"/>
    <dbReference type="eggNOG" id="COG4774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378515_0_0_10"/>
    <dbReference type="OMA" id="WLDNDFY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015891">
        <property type="term" value="P:siderophore transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="85"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="277"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="727" mass="81944" checksum="59B42DC858338749" modified="2009-09-22" version="1">MTADSFCCYESSSTIITPFIQLILKIKRMKGFVVLGLFASSVYAGQNVSDTLKTHTIESVNFTKRLPVTKEIINVQKDLDYKNLGQDLPVLLKNQTSVMSTSDAGNGVGYTGFRIRGVGGNGINVMMNGIPYNDSESQGTFFVNVPDLASSASQIVIQRGVGTSTNGVSAFGASVNVISKDPDADFYVKSDNSYGSFNTYKYSAEIGSGKFWKNRLSTMTRYTTIHSDGYIDRAFADLNSYSFTALFEENNTRLRLMAFGGKEKTYQAWNGIDKATWETNPKFNISGAIYDENWENIVGFYDNETDNYRQNHYQLLWDQSLNDHWTLETTLHYTKGKGYYENYKQGDPFARYNLPDVGGRKYADFIRKKWLDNDFYGAVSTLYGQLGDLDLNFGLVANQYYGLHYGNVSGVALPQISEHEYYRNRSIKSEVSGFAKAIFTVNRFEFFGDLQLRNISYDTRILLQGDDEGVDLNKNWNFFNPKAGINYKIPSGKVFISAAVAQREPNRDDLFANPDTEAEKLYDFEAGIEKSYDKISFNANLYYMSYVNQLVLNGQINNIGEFIRVNSGKSYRMGLEVGAAAKLSAQWNIAGNLTLSKNENISFRNETSNGIEELGNTPISFSPSAIANLLVNFSPTQNITLGIQNQYVGKQFLNNTNSDELTLPDYFLSDFNAKYTLKLNRTAIDFKFLLNNIFNRKYVNNGYVYDGPVYFSQAGTNFMFGMSVHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW5</accession>
    <name>C6WZW5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781797.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00175"/>
    <dbReference type="EnsemblBacteria" id="ACU06650">
        <property type="protein sequence ID" value="ACU06650"/>
        <property type="gene ID" value="FIC_00175"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00175"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_5_0_10"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="322" mass="36306" checksum="6F63DEFE56D9310F" modified="2009-09-22" version="1">MSRILTGIQATGTPHLGNLLGAIIPAIELSKKSDNESFLFIANLHSLTQIKNAGELRQNTYEIAAAWLACGLDTDKTFFYRQSDIPEVCELSWYLSCFFPYQRLTLAHSFKDKADRLEDVNAGLFTYPVLMGADILLYDAEVVPVGKDQLQHLEMARDMGSRFNHQMGEVFVLPTAELQEETKYVPGTDGQKMSKSRGNIINIFLPEKELKKQVMGIETDSKSLEEPKDPETDKVFAIFKLIATAEEAEFLREKYLAGNFGYGHAKTELLNLILTKFARERELFSYYMNNLPELEEKLQAGATKTREIAAKTLSKVRESLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZX5</accession>
    <name>C6WZX5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00185"/>
    <dbReference type="EnsemblBacteria" id="ACU06660">
        <property type="protein sequence ID" value="ACU06660"/>
        <property type="gene ID" value="FIC_00185"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00185"/>
    <dbReference type="HOGENOM" id="CLU_3099059_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="51" mass="5906" checksum="CBF9B10F5BD09CFA" modified="2009-09-22" version="1">MLMALEAKAKIDKKITSDVTKNFYNAAESIKKPPQHFRLRRLFTNLTIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X015</accession>
    <name>C6X015_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotase</fullName>
            <ecNumber evidence="7">3.5.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781847.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00226"/>
    <dbReference type="EnsemblBacteria" id="ACU06700">
        <property type="protein sequence ID" value="ACU06700"/>
        <property type="gene ID" value="FIC_00226"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00226"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_10"/>
    <dbReference type="OMA" id="SAETHHM"/>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="50"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="444" mass="49988" checksum="768D53D0CE218D55" modified="2009-09-22" version="1">MKILIKNARIVNENQITEGDLLIENGFISKIQKTIDDEEVDQLIDANGKYLLPGIIDEQVHFREPGLTHKGDIESESRAAVAGGITSFIEQPNTVPNAVTQELLEEKYSIAAQKSFANYSFMMGGTNDNLDEILKTNPRNVAGIKLFLGSSTGNMLVDNPETLENIFSRTKMLIAVHCEDEATIRANTEKYRSEFGDDIPMKFHHLIRSEDACYISSSKAVELAEKTGARLHVFHVSTAKETALFRNDIPLKYKKITAEVCIHHLTFTDADYETKGTLIKWNPAVKTQQDKDGLWKALLDDRIDVIATDHAPHTWEEKQNVYTKAPSGGPLVQHALPVMIEHFKNGKISLEKIVEKMCHNPAILFQIEKRGFIRESYKADLVLVDLDDSETVSKENILYKCGWSPLEGTELHSKVTHTFVNGNLVYENGEVKSGKFGERLLFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X056</accession>
    <name>C6X056_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ordered locus">FIC_00272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781888.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00272"/>
    <dbReference type="EnsemblBacteria" id="ACU06741">
        <property type="protein sequence ID" value="ACU06741"/>
        <property type="gene ID" value="FIC_00272"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00272"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_10"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="395" mass="43078" checksum="1B01CFEF9B95FCB8" modified="2009-09-22" version="1">MAKETFNRNKPHLNIGTIGHVDHGKTTLTAAISKVLSDKGYGTARDFSSIDSAPEEKERGITINTSHIEYETETRHYAHVDCPGHADYVKNMVTGAAQMDGAILVVAATDGPMPQTREHILLCKQVNVPNVLVFMNKVDMVDDPELLELVELEVRDLLSSYDYDGDNAPVIQGSALGALNGEPKWVATVEELMAAVDSWIELPVRDQDKPFLMPIEDVFSITGRGTVATGRIEAGVINSGEGVDIVGMGDEKLTSTVTGVEMFRKILDRGEAGDNVGLLLRGIEKTDIKRGMVIAKAGSVKPHKKFNAEVYILSKEEGGRHTPFHNKYRPQFYVRTTDVTGEIFLPEGVEMVMPGDNISIVVELLQPIALNVGLRFAIREGGRTVGAGQVTEILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X066</accession>
    <name>C6X066_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781898.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06751">
        <property type="protein sequence ID" value="ACU06751"/>
        <property type="gene ID" value="FIC_00283"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00283"/>
    <dbReference type="eggNOG" id="ENOG50346KD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128117_0_0_10"/>
    <dbReference type="OrthoDB" id="2074575at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="180" mass="21185" checksum="474CDD56E38EC00F" modified="2009-09-22" version="1">MKTICNILKYLSLVLLIFFLLKLTKHFGDYKRTVYDSILIPITVLLILINILILFKVQKRTKNYRIIKIVFLAGSLGVVIHVITNHFTQKREILTGYMINSKADLVLFKNQTFQITEYSPHIFQYWNGKYTITNDTLILTNIDFEKIPYLRLSQKYTYDKVSGNYIGSESILLKKNNHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X089</accession>
    <name>C6X089_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antibiotic resistance protein McbG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781921.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00307"/>
    <dbReference type="EnsemblBacteria" id="ACU06774">
        <property type="protein sequence ID" value="ACU06774"/>
        <property type="gene ID" value="FIC_00307"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00307"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_5_3_10"/>
    <dbReference type="OMA" id="GARFMDC"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="21290" checksum="DF6478F9D5828738" modified="2009-09-22" version="1">MTSISDQTFAKIDFTQNPLQKAEYEECIFDNCVLYAGSLSEITFLNCEFIDCDLSLVTVEATAFREVKFINCKMVGVNFEPANDFGLKLSFKNSNLSHAVFYRKDIRKTQFNNCILHGTDFTQANLSESSFANSDLAGSIFDQTRLEKADFRDAFNFSLVPEKNYMKKAKFSERNLAGLLMHSGIDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A6</accession>
    <name>C6X0A6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00324"/>
    <dbReference type="EnsemblBacteria" id="ACU06791">
        <property type="protein sequence ID" value="ACU06791"/>
        <property type="gene ID" value="FIC_00324"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00324"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066607_5_0_10"/>
    <dbReference type="OMA" id="AYQERCH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="157" mass="19102" checksum="0745BC8AFB62CAB6" modified="2009-09-22" version="1">MDQKKSYTFLEIKQKMAAYCSYQDRCHQEVEQKMRDFRLIPEAKDEILLYLMKENFLNEERFTRSYIRGKFYIKSWGRNKIRNHLKFKGVPEKLINNCFDEIDDADYEKTLHKIYENYYARQTGKEYQKKSKTVKYLLGRGFEYEEILDVQAKIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B1</accession>
    <name>C6X0B1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781943.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00329"/>
    <dbReference type="EnsemblBacteria" id="ACU06796">
        <property type="protein sequence ID" value="ACU06796"/>
        <property type="gene ID" value="FIC_00329"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00329"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_10"/>
    <dbReference type="OMA" id="GPRMPRD"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="323" mass="36064" checksum="55EFF6F9C8AE08D5" modified="2009-09-22" version="1">MKNILITGGAGFIGSNLCDHFIAKGYKVTCLDSFITGHRRNLIQLMEHPDFTLIEGDIREIETCRKACEGMDYVLHQAALGSVPRSINDPITSNDVNVGGFLNMLVAARDAKVKRFVYAASSSTYGDSASLPKVEDVIGKPLSPYAVTKYVNELYADVFSKTYGIECIGLRYFNVFGRRQDPNGAYAAVIPKFVIQLMKHQSPTINGAGDYSRDFTYIDNVIQMNERAMLTDNHDAVNTVYNTAVGDRTTIREMADLLKEYLSAYDPEIGNIEILHGPVRTGDVPHSKASIEKAMNLLNYSPSHVFKHGLKEAVDWYWEYLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B7</accession>
    <name>C6X0B7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipopolysaccharide biosynthesis protein wzxC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00335"/>
    <dbReference type="EnsemblBacteria" id="ACU06802">
        <property type="protein sequence ID" value="ACU06802"/>
        <property type="gene ID" value="FIC_00335"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00335"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026911_5_2_10"/>
    <dbReference type="OMA" id="DLAFYWD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="332"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="487" mass="54694" checksum="BF4D5CC7D83B4952" modified="2009-09-22" version="1">MVNKTQFSMSLKKQAISGMLWTFAQQFSVQGISFVVSIILARLLLPAEFGLIAMISVFVGLANALISSGMTQSLVRTEILDDDDFSTVFYFNLGVSILMYALIYALAPFIADFYRQELLVNILRVYSIVFVIDALAAIQVTRLTKVLNFKTQMKVAVPSLILSGMVGVGMAFYGFGVWSLVGAALTKSFFNTVQYWLWSSWRPVFRFKMEKFRQHFNYGIKILLAGILEIIFSNGITIIIGRFFLPAQVGFYQRADTLKQLPVVNITYMVDKVAFPLFASIQHDDVRLKNAYKKIMQMVIYLIAPVMLILAAVAEPLFRFLFTEKWLPSVPYFQILCLNGLLFPIHSYNLTILKVKGRSDLFLKLEIVKKIIIAVVILLSIQYGIYGLLYGSVISSVLCFFVNTHYSGKFLDYPGFSQLADVLPLLLLGAAAAAVAFGADFFLKTIEAADIIRLLISGFAGILFYAVISHLFKISSFSELKLIILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G0</accession>
    <name>C6X0G0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781993.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00379"/>
    <dbReference type="EnsemblBacteria" id="ACU06846">
        <property type="protein sequence ID" value="ACU06846"/>
        <property type="gene ID" value="FIC_00379"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00379"/>
    <dbReference type="eggNOG" id="COG3665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079904_1_2_10"/>
    <dbReference type="OMA" id="HNINFFM"/>
    <dbReference type="OrthoDB" id="969451at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="198" mass="22066" checksum="0CBE215C094D23AB" modified="2009-09-22" version="1">MNPEFTTIERQTGKAFLVNKGDILTVRDPLGQQVSDMVLFNRHDHDEKISSGKTLDFEESILITAGNYLWSNRSRKMMKIIADTNGRNDFLLAPCSKETFEIMYSHTGYHPSCLENLAKNLAPMGILQDDIPTAFNIFMNVQFDAQGKISVLPPTSKAGDYIQFEAQMDLLVCLTACSAEDSNGGSFKPIQYLVNTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0H9</accession>
    <name>C6X0H9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ordered locus">FIC_00398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782012.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00398"/>
    <dbReference type="EnsemblBacteria" id="ACU06865">
        <property type="protein sequence ID" value="ACU06865"/>
        <property type="gene ID" value="FIC_00398"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00398"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_10"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="371"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="282"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU06865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="488" mass="55707" checksum="87219DF7DD8B5F0F" modified="2009-09-22" version="1">MSLKIYNSLSGDKEIFTPIHENNVGMYVCGPTVYSNVHLGNVRTFMSFDFVYRALTHLGYKVRYVRNITDAGHLTDDGDVDNDRFVKQSRLEKLEPMEIVQKYTVDFHKVLDVFNLLPPTIEPTATGHIVEQIELTQKLVDKGFAYESNGSVYFDVQEYNSRGLNYGELSRRNIEELFANTRDLDGQNEKKNPQDFALWKAASPAHIMRWNSPWGEGFPGWHLECTAMSTKYLGEKFDIHGGGMDLKFPHHECEVAQGKACNGTEPVNYWLHANMLTMNGQRMSKSTGNYILPMELVSGSNSFFEKAFHPAVVRFNFLQAHYRSVLDISNEAMLASEKGFQRLMDAMKILSDVQLKTASNSTFDVEAWKKKCYDALTDDFNSPILISHLFEAVNFIFRLKDGKETVTSTDLENLKQLLNDFVFDVLGLQNVEENNHQKLDQALQVLIELRNQARKAKNFDLSDQIRDRLLAEGIELKDGRDGTTYALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I2</accession>
    <name>C6X0I2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782015.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00401"/>
    <dbReference type="EnsemblBacteria" id="ACU06868">
        <property type="protein sequence ID" value="ACU06868"/>
        <property type="gene ID" value="FIC_00401"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00401"/>
    <dbReference type="eggNOG" id="ENOG5033AAP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1755602_0_0_10"/>
    <dbReference type="OMA" id="QMNTEMR"/>
    <dbReference type="OrthoDB" id="2041511at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973540" evidence="2">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="135" mass="15776" checksum="5AE39B3817019054" modified="2009-09-22" version="1">MKKLVLSAAFLIVGTFAMAQQTPMMQKKDPAQMEQKRAEKLKAMQTEYQLSDAQVAQIKALQDRKMAERKQNAPQVQAERKAKMEAMKAKREQMNTEMRQILTPAQYQKWEAKKQEQMKNKQANMRQMKKMPAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K2</accession>
    <name>C6X0K2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2059 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782035.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00426"/>
    <dbReference type="EnsemblBacteria" id="ACU06888">
        <property type="protein sequence ID" value="ACU06888"/>
        <property type="gene ID" value="FIC_00426"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00426"/>
    <dbReference type="eggNOG" id="COG3184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107918_0_1_10"/>
    <dbReference type="OMA" id="QESMMAG"/>
    <dbReference type="OrthoDB" id="1604355at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018637">
        <property type="entry name" value="DUF2059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09832">
        <property type="entry name" value="DUF2059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970512" description="DUF2059 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2059" evidence="2">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="154" mass="17799" checksum="7C86F26EB2370E0D" modified="2009-09-22" version="1">MKKNIIAVTFMAFGVFANAQTTKEIKIAELLETMGTTQAMKTSYEYMIEHYKKSYPSISGEYWDRATSLVNYEDLVQKLVPVSTKHFSEQEIEDLIAFYRTPTGKQMITKMPAILQESMQIGQTWGVELAEKIEKNLPQTKQQYDNPPPLMRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L0</accession>
    <name>C6X0L0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00434"/>
    <dbReference type="EnsemblBacteria" id="ACU06896">
        <property type="protein sequence ID" value="ACU06896"/>
        <property type="gene ID" value="FIC_00434"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00434"/>
    <dbReference type="eggNOG" id="ENOG5033J47">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1710390_0_0_10"/>
    <dbReference type="OMA" id="IFPQSIN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="166" mass="19186" checksum="F98B31138AD31FA8" modified="2009-09-22" version="1">MTNRDFFRLMIKLFGLYQFLIVVFTVLPSQFNVMFSDFFSKWITVSSFALLSILILGIFYFLIKSPDKIIDFFKLDKGFDSEKIAINNLSSSAILQIGLILIAGFLIVDNFASFFSKLIYYFKMNFLPEDLRGLQNSEDLIFSGINLILGFILIIFRKQIAEKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0R0</accession>
    <name>C6X0R0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ordered locus">FIC_00487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782093.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00487"/>
    <dbReference type="EnsemblBacteria" id="ACU06946">
        <property type="protein sequence ID" value="ACU06946"/>
        <property type="gene ID" value="FIC_00487"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00487"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_10"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="293"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="466"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU06946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="617" mass="68135" checksum="BECF38843F8E0400" modified="2009-09-22" version="1">MCGIVGYTGFQDAYEVVINGLRRLEYRGYDSAGIVLDSESQPFQVAKTKGKVDDLVAISEDLRGKANVAMGHTRWATHGVPSDRNSHPHVSNNAKIALVHNGIIENYDTIKIMLTEKGFIFHSETDTEILVNLIQYFMDTNAELDFPTAVRFALNEVYGAYAITVMHDDFPGVLVVARLGSPLAIGLGNKEYFIASDASPFVAFTKEAVYLEEGHMATISLENGVDIRNIIDNLKIIPEVQELKLSLEQIEKGGYEHFMLKEIFEQPKSIHDTLRGRLLVDEGIIKMAGIWDHLDRISQAQKITIIACGTSWHAGLIGEYLIEEFARIPVEVEYASEFRYRNPIITEKDVVIAISQSGETADTMAAIKLAKEKGAFIYGICNVVDSSISRVTDAGSYTHAGPEIGVASTKAFTAQLTILSLIALKLGKHNGHLSNQEFMKLITELDALPKKVQEVLESTHEITQEIAKQFIDAQNFLYLGRGYNFPAALEGALKLKEISYIHAEGYPAAEMKHGPIALIDENMPIVIIAPKQGHYDKIVSNVQEIKARKGKIIALVNKGDTQVSSVADYVIEFPETSECFSPIVASVPLQLLAYYIAVYRGANVDQPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S0</accession>
    <name>C6X0S0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01586"/>
    <dbReference type="EnsemblBacteria" id="ACU08033">
        <property type="protein sequence ID" value="ACU08033"/>
        <property type="gene ID" value="FIC_01586"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01586"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_7_0_10"/>
    <dbReference type="OMA" id="ESCIMSF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="217" mass="24861" checksum="BC6F03122661B5C8" modified="2009-09-22" version="1">MSAIIGKFVPMDPLEQIIEFKTSPELISKLRQHSMAKAYSAGDLILDENSAIRAIPIVTKGTLKVMRTEEDGREILLYYIKAGESCIMSFLGGMHDEKSKVKAEVEEDAEILFLPMEKVHLFIKEHPEWLDYIFRLYHKRFEELLEIVNAIAFKKVDERLLSLLHKKQELTGSKTLSITHEQLANELGTARVVVSRLLKQLEENGNLQLGRNKIILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0U8</accession>
    <name>C6X0U8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806346.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01615"/>
    <dbReference type="EnsemblBacteria" id="ACU08061">
        <property type="protein sequence ID" value="ACU08061"/>
        <property type="gene ID" value="FIC_01615"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01615"/>
    <dbReference type="eggNOG" id="COG4389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023672_0_0_10"/>
    <dbReference type="OMA" id="HYITRDR"/>
    <dbReference type="OrthoDB" id="161332at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011385">
        <property type="entry name" value="Site-sp_rcmbase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10136">
        <property type="entry name" value="SpecificRecomb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="678" mass="77563" checksum="117BB98D09A6FEE6" modified="2009-09-22" version="1">MTPFYNRNKATFNTVLSKFFSFRNETKSLEPLSELMLHLRRTPFEEILDFLRGNADVAENFGFYINHLFEGKPFNLSLTEANIISENSFFPEFKKRLLDKVLPAVENENSVWVLVDTASVRPIKDLDYFRNLSEAQLDEFFILLGIDDFISRPKAKQELLFSLNILAWRVIGNAMDAEVVNMVPEYRKFDNPFLALQNEFDVLNENFAKDHGYFLHSRDMLYKQIKVYMGQCLDFVTLAFKNSEKYGISGKINQSLIKIRQQLNRMTDILNILVVDDKEDVLRNSKMLFFNILEYKTHKNNIRDLISDSTTLMSHLITNHTAETGMHYITSSKSDYVSMFLKASGGGIIVACLVVLKLFYGSLPGSDFSHAVLFAFNYAMGFIMIYLMNFSLATKQPAMTAATMAKVLSEGENTRENYIDFAHIVSKVFRSQFIAFMGNVLLSFPVALAIVYGLDVIFQQNFAAEKATKLLSDHDPFQSKAILHACIAGFFLFLSGIISGNVGNSSVYYNIPKRIAKNPLLNYFLGERTAQNMSDFYARNAAGIVSNFWFGIFLGVTGPIGIFLGLDLDIRHITFAAGNVALGFYGKGFEVNMYTVWISIITVFVIGFFNFAVSFGLSMLLAFRSRKINFHELREIYREIFRYFMKNPFRFFLPIRSELDGKTADMLNYKKATRSEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0V1</accession>
    <name>C6X0V1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806349.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01619"/>
    <dbReference type="EnsemblBacteria" id="ACU08064">
        <property type="protein sequence ID" value="ACU08064"/>
        <property type="gene ID" value="FIC_01619"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01619"/>
    <dbReference type="HOGENOM" id="CLU_2632848_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="77" mass="8598" checksum="E06950D137B418BA" modified="2009-09-22" version="1">MLVTKSKELIMLPLLKTVEQPYFSHRETLHFPQSPGSGSSILKIKKESSDQNTDNGSEESSVSETIYVWDGSGLRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X128</accession>
    <name>C6X128_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ordered locus">FIC_01698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806426.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01698"/>
    <dbReference type="EnsemblBacteria" id="ACU08141">
        <property type="protein sequence ID" value="ACU08141"/>
        <property type="gene ID" value="FIC_01698"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01698"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_2_0_10"/>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="190" mass="21817" checksum="FB0EA9DC4EFB3AFB" modified="2009-09-22" version="1">MILPIRAFGDAVLRKHCQEITKDYPDLDELIANMFDTMNSAHGIGLAAPQVGLDIRLFIVDLSPLAEDEDYADIADELKDFKKVLINAKILEETGEEWKFNEGCLSIPDIREDVKRKETIVIEYYDENFVKHTDTFSDMRARVIQHEYDHIEGILFTDHLSSLKKKLVKGKLVKISNGDVAVTYKMRFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F5</accession>
    <name>C6X1F5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01825"/>
    <dbReference type="EnsemblBacteria" id="ACU08268">
        <property type="protein sequence ID" value="ACU08268"/>
        <property type="gene ID" value="FIC_01825"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01825"/>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="354" mass="39815" checksum="F4AAF1F438DA9D67" modified="2009-09-22" version="1">MILRGENLIKEYGPKKVVKGVSVEVAQGEIVGLLGPNGAGKTTSFYMIVGLVKPTAGKIFLDDKEITNDAMYRRAQKGIGYLAQEASIFRKLSVEDNILGVLQLTKLSKREQQMKVDELIEEFSLQHVRKNRGDLLSGGERRRTEIARCLATNPNFILLDEPFAGVDPIAVEDIQKIVRSLVDKNIGILITDHNVQQTLAITHKTYIMFEGRILKEGLPHDLANDPMVREAYLGENFVYQDILNKPKKKSFVYNIWAGNFDSKAQFQDFVSTRFEGVEGLRLMYGFEDISFASLSSSEIEHIFNEVVDKNANNAFVFQKKLVSDTFSKDAAESAAQLLSTPELHYLTTFSYESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H4</accession>
    <name>C6X1H4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_01844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806572.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01844"/>
    <dbReference type="EnsemblBacteria" id="ACU08287">
        <property type="protein sequence ID" value="ACU08287"/>
        <property type="gene ID" value="FIC_01844"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01844"/>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_10"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="330" mass="36357" checksum="340F1D700F1B534C" modified="2009-09-22" version="1">MIIYSRNRRLRTNSSIRALVQETVLTTNDFVMPIFVMEGENKQEPIASMPGIYRRTLDLTVKECRELFSLGIKGINLYMKVSENLKDNKGTEAWNANGLMQNTIKAIKDAVPGMVIMPDVALDPYSVYGHDGIITNGKIDNDATNDALVKMSVSLAEAGADFMAPSDMMDGRVAAIRTGLEENGFTDVGILSYAAKYASSFYGPFRSALDSAPKEDSEIPKDKKTYQMDFHNAREAMDEVYKDIAEGADIIMIKPGMPYLDIVSKVREAIDLPIAVYNVSGEYAMLKAAAQNGWLDNDKAIIESLTCIKRAGADIIFTYAAKEAAILLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L1</accession>
    <name>C6X1L1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase, family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01881"/>
    <dbReference type="CAZy" id="GH28">
        <property type="family name" value="Glycoside Hydrolase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08324">
        <property type="protein sequence ID" value="ACU08324"/>
        <property type="gene ID" value="FIC_01881"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01881"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_8_3_10"/>
    <dbReference type="OMA" id="VKSGWDH"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972222" evidence="5">
        <location>
            <begin position="41"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="491" mass="54499" checksum="4BF6B4B96FAFCC07" modified="2009-09-22" version="1">MNYRVQRFISARFVFPMVLMAFSALVFLYACSAASNNAIAIGSTDSFPMERMLELEKSIKEPKFRDANYNIVSYGAVADGKTMATESIRKAILACSKDGGGKVIVPSGKFLSGPIHLENNVNLHLMEGAEILFSTNPDDFYPLVHTSFEGMELMNYSPLIYAKNKKNIAVTGKGILNGQASNDNWWTWKGSSAYGFKPGMPSQLDPNNLPKLMEMADTNVPVSNRTFGNGRYLRPNFIEPFECENVLIQGITIINAPFWILHPIKSKNIIVDGVNIRSHGPNNDGLDPEYSQNVLIKNSIFNTGDDCIAIKAGRDEEGRRVGIMTENIIVRDCKMIDGHGGVVIGSEMSAGVRNVFVYNNHMDSPELDRAIRLKTNNVRGGVVDGVYVKNLTVGEVKEAVLHITMNYKDYKNRTGNFTPQIRNILLEDVKVKNGGKYAIFADGLENSKIQNITFKNVTIDKVKANFNVKFVENLKLINTKINGAQTEYAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S8</accession>
    <name>C6X1S8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CHU large protein uncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01949"/>
    <dbReference type="EnsemblBacteria" id="ACU08391">
        <property type="protein sequence ID" value="ACU08391"/>
        <property type="gene ID" value="FIC_01949"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01949"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234846_0_0_10"/>
    <dbReference type="OMA" id="WSQNANP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1947" mass="203253" checksum="8664A9D94923AD89" modified="2009-09-22" version="1">MMNRNLLPLRDALRCTLISAPSKIQIFSVKAPYRTVLKSLLTIFLMLCSLGVSGQTTIFSENIGTPSGTTLIPAYSTGTAPATFQNKGTLSYSGDSDVRTSSPSSAYTGASANGNVFITNASNRYFTIYGINSSGYTGLSLSFGLLKSTAVTTPLTSVQFIVEVATDYNSTTNTGTFTALNFPTITTGATWSLITPTGTIPASSTLAIRFRQNQTTAQVRIDDVKLIGTAPTGKTSNCSVCSWNDPNAWLPVGVPTATDNVTIRATDIIYSNNAALLRTAATYVNGSFQIENGFSIDNASTNFNYGPAGTLIFKTTGPYGVSSNDEYWPYTNGPVNVRVLQGGFTLNSGVTRIVTGNLETAAGISMAVGENLTINGTATINTAGFFSSTPTFGPTSTLEYKNQGGYNVGNEWTGNATAPGLGVPKNVNLVSATINIPNFSHGLAGNLNIDSNSTLNLNSSSGDLFIAGNWTKAGTFSPNSRAVFFNGTTAQTITGPTTFDYLTINNTAGVTLASSITNNYSLDFINGKLTLGTNDLTIGPGGTIANAAAAKYVVTNSTGQLKRTVGNGSVLFPVGNAAYNPITFNNSGTSDLYGVRVVDAAPAGANPAKTVNRQWVTTEDVAGGSNLSVMAQYNIAEIGNGFAAANNPFIGIYNGTSYSQQVAANVTTSDPATATSTTNLTPTDLTTGTKYFAIGKDNGLVSVPTKFVISNITPASPVAGSGFSATVTAQDAYNSASLISSASSFNLTTNGNAGAIAGTTSGTIAAGNNSVVVSGIILPNPGTSVTLTATNSSGLTLASGTSAPFTVLGVATKLKFVSVPGTGTVGSNLASFKVEAQRADNSVDTNFTGSVTITKTTGPGNILGTLTKTAVAGVATFNDIQFDAPGTYTITTTSGSLASDTSGNIVIAPNPANAFFRSNATVGNWNVPGNWESSNDGITWNNATLFPTSAANTVTIRNENTITIASDVTLDQLIIEDKGTLSVNVNSGKLNINDGVGIDIDIKSGGVLQVFSTASASNISYSEKIKFISSASMNVSGKIVVGNGNNFMGGRYGEFGYASAAQIIWNNSAVLEWNTGGSSPEVSGKVYFPDVPSTTVPVFRITKSNAGFNGDSNLIVNGIFQLSGTDVTFAQNGLRTFRNGIVCFGTCKMSISGVSGAWQIGDGTEPVSAELGGSTGNLTLTNSNGITLLNKSSTTLTSTIKMGISTKFTVETGAVLNFGFDSSGNALNLERAGVANLTAFEAKSGSTLKITSPAGISNVAGDYTGNVQVGSTAENRIFSPDATFHYIGKANAAQVSLNGVDQISGNGLPSGASDKNIIIDLDTTNPAQDNVSFKAIGIYKFTSAGLLKIIKGKVIDEIGNGFADGAFADGNLTMTGGRYRISRAGLQPSLGGIYDLTGGVIELATSSTGIQIRTGALSNLKEYYKIEASGMNIEPSGKNLLVNHTTTVTNTGILTIPASPDNSSPNVVTSKRGVTILGNGILSLENNAQLMQDEDAVNTGNITARRTATIPISTFNQYAYWSSPVNSQNFRDIFPAYPTTALYYNESNDKFYTSSGVYIAGRGLAVRNPIIATGTATNLSALFTGVPFVGNLPYNLAFTDSSHGYNLVGNPYPSNLDLDLLYSNSTDIESTFRFWDNTSNVQQSQLGSGYQGYSYAIYNAASGTGLPSPGTGVGATNNVGKVPNNIVKVGQGFLTRAKTNVAKLNFKNDQRITAQTKAQFFGKNSADSIRDRYLIELVTPANLVISNAVVYFGNGNNDLAADDSKLVSGMSDALFTNAGDEKVVINGRNTFQDNDVLEVGNRYFADGVYQIRLGTTEGTFANGQHIYLKDKQTGTVTDLSEGNYTFMANAGVSTGRFEIIYRPETVLATDGNNVENLVVYRDGNNFVVKATDAKIDAIDIYDAVGRLIRRLEPRSTTALIDASTFVNGSYILKIDQGNLSTVKKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1X1</accession>
    <name>C6X1X1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ordered locus">FIC_01992</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806719.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01992"/>
    <dbReference type="EnsemblBacteria" id="ACU08434">
        <property type="protein sequence ID" value="ACU08434"/>
        <property type="gene ID" value="FIC_01992"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01992"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_10"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="138"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="431" mass="46519" checksum="D3C392DC7E215B4A" modified="2009-09-22" version="1">MSYISYIEARQILDSRGNPTIEVDVFTESGAMGRAAVPSGASTGEHEAVELRDGGSVYMGKGVLKAVENVRDVIAPELVGLQVYDQNFIDQIMIELDGTKNKGNLGANAILGVSLAAAKAAAAELKMPLYKYVGGVNANTLPVPMMNVINGGSHSDAPIAFQEFMVMPVKADSFSHALRKGTEIFHSLKSILHSRGLSTAVGDEGGFAPTFKGTEDALDTLLQAIEKAGYKPGDDIMIALDCAASEFYKDGTYDYRKFQTPDSAQFSSSEQVSYLAELASKYPIISIEDGMHEDDWAGWKELTEKIGDRVQLVGDDLFVTNVERLSRGINEGIANSILVKVNQIGSLSETMAAVQMAQHNRYTSVMSHRSGETEDSTIADLAVAMNCGQIKTGSASRSDRMAKYNQLLRIEEALGETAIFPGLDTFKINRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y5</accession>
    <name>C6X1Y5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ordered locus">FIC_02006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806732.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02006"/>
    <dbReference type="EnsemblBacteria" id="ACU08448">
        <property type="protein sequence ID" value="ACU08448"/>
        <property type="gene ID" value="FIC_02006"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02006"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_10"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="181" mass="19662" checksum="CC1A7F36D3B3B5D0" modified="2009-09-22" version="1">MSRIGKAIIEIPANVTVTEKDGLVTVKGPKGELTQQLAEGITLKQEDGVLTFDRASESKQHKALHGLNRALINNMVQGTAEGWTKKLELVGVGYRASNQGNRLDLALGFSHGIVLDLPKEIVVETLSEKGKNPIITLTSHDKQLLGMVAAKIRSFRKPEPYKGKGVRFVGEIVRRKAGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X234</accession>
    <name>C6X234_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806781.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02055"/>
    <dbReference type="EnsemblBacteria" id="ACU08497">
        <property type="protein sequence ID" value="ACU08497"/>
        <property type="gene ID" value="FIC_02055"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02055"/>
    <dbReference type="eggNOG" id="COG2388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132888_2_1_10"/>
    <dbReference type="OMA" id="PHCSYAR"/>
    <dbReference type="OrthoDB" id="1872172at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="11109" checksum="8F90B04D1F5900DE" modified="2009-09-22" version="1">MNYINDKSGNGGAIRLNNETEEIGRLTYTILPEDNKLIISYVLVHHKFEGRGMGKYLVDEAVKFARDNQWKVYPHCSYARSVMNRMNDVDDVLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X242</accession>
    <name>C6X242_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ordered locus">FIC_02063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806789.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02063"/>
    <dbReference type="EnsemblBacteria" id="ACU08505">
        <property type="protein sequence ID" value="ACU08505"/>
        <property type="gene ID" value="FIC_02063"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02063"/>
    <dbReference type="eggNOG" id="COG0757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_3_0_10"/>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="OrthoDB" id="1872106at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="96"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="136" mass="15394" checksum="CD6AED5FD3AD0222" modified="2009-09-22" version="1">MNILIVNGPNLNLLGTREPEIYGNLSMEDFFSDLQKDFPAHTLAYYQSNVEGEIINRLQQDDFEALIINPGAFTHYSYAIADCLKNISKPKIEVHISNIYQREEFRQKSVTAVHTNGVLSGFGIEGYRLAVLSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X272</accession>
    <name>C6X272_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806819.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02098"/>
    <dbReference type="EnsemblBacteria" id="ACU08535">
        <property type="protein sequence ID" value="ACU08535"/>
        <property type="gene ID" value="FIC_02098"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02098"/>
    <dbReference type="eggNOG" id="COG3230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085041_0_0_10"/>
    <dbReference type="OMA" id="DFICENE"/>
    <dbReference type="OrthoDB" id="1608763at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="183" mass="21296" checksum="6C52647DC24B854C" modified="2009-09-22" version="1">MISDRLKTETRYLHDLTEEKFNSKKIFESTFSLEDYRKVLLYNYFLISNFEDAVFSLIPTDAALKIQLEKRRKLKLIETDLQNFGTELPPQEFSVTVNSEAEAWGVFYVMEGSTLGGNMIAKQLSKNAEFKNVNFSYFRCYGEHTGSYWKSFKEVLDQQVAPEKFEECIAGANKAYRFLLDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X295</accession>
    <name>C6X295_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806842.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02121"/>
    <dbReference type="EnsemblBacteria" id="ACU08558">
        <property type="protein sequence ID" value="ACU08558"/>
        <property type="gene ID" value="FIC_02121"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02121"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1720962_0_0_10"/>
    <dbReference type="OMA" id="KKREFAY"/>
    <dbReference type="OrthoDB" id="1813832at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="152" mass="17484" checksum="6E22F1B9FC65774E" modified="2009-09-22" version="1">MKELLLKQKQIFFFIVAGALSAAVEIGSFKVFSVYLPQIFSQEYNFHGIHFPLSNIFSTGCGILTNYFLSIWFVFERGKHSKKREFAYFMGISALSTLISLSFFQIFFRSIFLQHIDIGFFVFSREILSKVSAIVLVSVLNYSVKKKIIFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C4</accession>
    <name>C6X2C4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806871.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02151"/>
    <dbReference type="EnsemblBacteria" id="ACU08587">
        <property type="protein sequence ID" value="ACU08587"/>
        <property type="gene ID" value="FIC_02151"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02151"/>
    <dbReference type="eggNOG" id="ENOG503340P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1601640_0_0_10"/>
    <dbReference type="OMA" id="WNFGHIT"/>
    <dbReference type="OrthoDB" id="1846996at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="19852" checksum="007B5406B358A139" modified="2009-09-22" version="1">MKLKGVDKNFWWNFGHITDSRQIPTELLGFTSIDSEIDDEYLAILFSAVKTIGSIYLKETQITDEGVKSLSSVGQLRHLTVMKHPGISRESLPYLNQLTDLEYLDVWRTGIILEDLRELSQLQKLKELYVSATKADEDGNYAEMEREKILEHVIELEDLFPGCAVYVDFDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C7</accession>
    <name>C6X2C7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="6" type="ordered locus">FIC_02154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806874.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02154"/>
    <dbReference type="EnsemblBacteria" id="ACU08590">
        <property type="protein sequence ID" value="ACU08590"/>
        <property type="gene ID" value="FIC_02154"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02154"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_2_3_10"/>
    <dbReference type="OMA" id="TTGEMHL"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="67" mass="8077" checksum="F829E7EB477CD6A5" modified="2009-09-22" version="1">MAHPKRRQSSTRRDKRRTHYKAEVPQLAKDATSGEMHLYHRAHWFEGKMYYRGKVVMEKTTETEVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D8</accession>
    <name>C6X2D8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase, RecQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02165"/>
    <dbReference type="EnsemblBacteria" id="ACU08601">
        <property type="protein sequence ID" value="ACU08601"/>
        <property type="gene ID" value="FIC_02165"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02165"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_10"/>
    <dbReference type="OMA" id="GNYKFLY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="47"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="239"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="655" mass="76569" checksum="5FA90E104564D207" modified="2009-09-22" version="1">MTFFVWWVLFQYFYSMISPQDFHALKFQTLQHFWGHSTFRDSQEEIINAVIAGKDTLALLPTGGGKSLCYQLPAIILDGICLVISPLLALMKDQVYHLKNNGIEAEYLSSELDEFDAETIFNRCREGITKLLYISPERLTNRMFLQNLEVIKLSFIAVDEAHCISEWGQDFRPSYQNIKPFREQFRNIPCMALTATATPKVLHEIQLKLNLKEPEIFQKSFRRTNIKIVSDNISDKYQRLLDLMKYNSSCGIVYVRTRKESEELVKFLQRNKIPNVDFFHAGLPVKEKNAKQNLWINSQNNVLISTNAFGMGIDKDNVRFVMHFSPPQSLENYYQEIGRAGRDGGDSSAFLLWNEQELADFDQILRNQTPSRNEFYNIVSYLYSAFQIAESEMPESVFQLHLQRVQNFTKVSAAKIKNVLNFLHNQEIIFLNSYRSLSSLTLKISPEELDLLSKKDSYFIELLLRNYSGLATHKIMFSEQTLANKIQTEVQIIKDRIRDMQQKNYVEYIDGALWSVKFLQPRDERANKGKYWHLFEQIQKNKLQKWEEMKFFVQDNEYCKMKMILSYFGEKNAKNCGKCSVCDKQRESVFGRDVSREIIEILKQKPSNVEEIAVKLNYYAKESILENLIHLLDSGKVQMLNFRTYAYRDEVPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G1</accession>
    <name>C6X2G1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08624">
        <property type="protein sequence ID" value="ACU08624"/>
        <property type="gene ID" value="FIC_02188"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02188"/>
    <dbReference type="HOGENOM" id="CLU_3365107_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="4105" checksum="B2D6691A606F53E6" modified="2009-09-22" version="1">MNDFAVFSHITKIIYFPQAGFITPDLIFYPSQRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J0</accession>
    <name>C6X2J0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetate-CoA oxygenase, PaaJ subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02218"/>
    <dbReference type="EnsemblBacteria" id="ACU08653">
        <property type="protein sequence ID" value="ACU08653"/>
        <property type="gene ID" value="FIC_02218"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02218"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082133_0_0_10"/>
    <dbReference type="OMA" id="EPFDHFK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011883">
        <property type="entry name" value="PA_CoA_Oase4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02159">
        <property type="entry name" value="PA_CoA_Oxy4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="182" mass="20753" checksum="4B6215459A40F64D" modified="2009-09-22" version="1">MKCTRIPQVFTDVLFKSVKTCVISEKKKMQNLLEILSRIPDPEIPVINIVELGIVREAKMLSENEAEIVITPTYSACPAMFNIEEDIIKLFRENGISAKVITKISPIWTTDWITDEAREKLRVYGITPPEKGSHEDHLNVPKKCPRCASVNTKQISRFGSTLCKASYQCNDCLEPFDYFKCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K1</accession>
    <name>C6X2K1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S12.008"/>
    <dbReference type="EnsemblBacteria" id="ACU08664">
        <property type="protein sequence ID" value="ACU08664"/>
        <property type="gene ID" value="FIC_02229"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02229"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_1_10"/>
    <dbReference type="OMA" id="MGYGIFL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="370" mass="40911" checksum="1906DC6E541ADEC0" modified="2009-09-22" version="1">MTRYFLPLLLYIFVACKSESPKPLSSGEDAISVKDTVREWEQKKMLRIQLDSVFAETNLNGIVSVYRNSQKYYERAQGFEDFKTKKPLDSNSIFAIGSVSKQFAAALIMRLEENGKLSTADKISKYLPEYRSKTFEEITIHHLLTHTSGISDLGPGLQSKPGAEFNYSNKGYRILGEIVESASGKSYDENARELFDKANLTNTYTAENFKGKNLASAHTGTAKNATAVENMPGRLAHSSISTAAGGILSTASDLHRWNLALYNGKLLQPNSLKKFLAKTSVMKHPVIGPVDYGYGIMLAARPASYLHTGYVLGSPTLLIYYPFSKTSVVIVSNIADTSKSKNNIFLPHTEVKKVTDVLENAPIELKTSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L5</accession>
    <name>C6X2L5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02245"/>
    <dbReference type="EnsemblBacteria" id="ACU08678">
        <property type="protein sequence ID" value="ACU08678"/>
        <property type="gene ID" value="FIC_02245"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02245"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2316137_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972247" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="99" mass="10803" checksum="F3483A9E3B278667" modified="2009-09-22" version="1">MKKLTVALALLTGIVSFAQGNPKSDTAQVHNIQEVLMTKSVFKKQSDRFVYDLSNTPVAKGNTTFDVLKQTPMLSSTDDSTLKIAGKNNAVIYVNGRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M8</accession>
    <name>C6X2M8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02258"/>
    <dbReference type="EnsemblBacteria" id="ACU08691">
        <property type="protein sequence ID" value="ACU08691"/>
        <property type="gene ID" value="FIC_02258"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02258"/>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1833051_0_0_10"/>
    <dbReference type="OMA" id="QWWLIRT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SSF50044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="2">
        <location>
            <begin position="76"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="77"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="141" mass="14985" checksum="E763724635D39456" modified="2009-09-22" version="1">MNMSTLQDKYAGVISAAQSAGVRNLQVTEQNGILYVSGDAASTAVKDTVWNALGAIDTTYSASDINLNVQVSGLSSGASLTVATENSNLNLRQEPSTDATIIGKANKGETVTLVEQTSDDWWKVRTADGEEGYAYSRYLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q2</accession>
    <name>C6X2Q2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02282"/>
    <dbReference type="EnsemblBacteria" id="ACU08715">
        <property type="protein sequence ID" value="ACU08715"/>
        <property type="gene ID" value="FIC_02282"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02282"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030508_1_0_10"/>
    <dbReference type="OMA" id="IFYRPAV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="302" mass="34501" checksum="A7A722FA79BB139B" modified="2009-09-22" version="1">MSCLNTSHIALHTNVLKHLSLIFKKVDMKRLISLIMFVFCLTVSAQNLKVMTYNIRLALDSDKENSWENRKTDALKLLNYYHPDVLGVQEAVPQQMSDLKNGLAGYNFVGVGRDDGSNKGEYSAIFFDTAKLQVLQSGTFWLSETPEKPSKGWDAAYNRICTFALFKTKKGRRKFWAFNVHFDHVGNIAREKSAALILSKIKELNTKNLPVILTGDFNLTDKTTPMKILSENLSDTYRNCAQPSYGPTGTFTAFDVNKIPTERIDYIFIKHLKCKSHRTINDRRENLLYPSDHFPVMAELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q4</accession>
    <name>C6X2Q4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenylacetate-CoA oxygenase/reductase, PaaK subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02284"/>
    <dbReference type="EnsemblBacteria" id="ACU08717">
        <property type="protein sequence ID" value="ACU08717"/>
        <property type="gene ID" value="FIC_02284"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02284"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_14_1_10"/>
    <dbReference type="OMA" id="MQVHHIH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="300"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="390" mass="44165" checksum="A197F4D4AF2A8246" modified="2009-09-22" version="1">MWQGAVQYNSQKSIIFVKVSLTKSLSIYMHHFHQLKTTKIAKKTNDSVNIAFEIPPHLKQEFAFKQGQYLNVRFIFNGEDLRRSYSIVNAPTEGNAELEILVKHLEDGKVSTYLNTNLAVGDLVEVSAPMGHFYTHHHPSNEKTYVGLAAGSGISPVLSNLKEALYQEPKSTAYLFFSNKSFNDIIFKDEIDAVAEQFGGRFKVIYLLSREKHFEDELFEGRICAPKLDELLDRFAEIPVQNSTFFICGPSEMIKSVSAYLKNEKKVPSLQIMYEYYAAPDDEDNAEMSDEFKAIPNLESMVTLIIDDDEYSFHLNSKKKSILDQALDDKLPVPFACKGGVCCTCKAQVMEGEVFMEKNFALTEDEVARGFVLTCQCHPTTNVVMLNYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S3</accession>
    <name>C6X2S3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08736">
        <property type="protein sequence ID" value="ACU08736"/>
        <property type="gene ID" value="FIC_02303"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02303"/>
    <dbReference type="HOGENOM" id="CLU_3396634_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="31" mass="3646" checksum="AA6B5578C5EDF64B" modified="2009-09-22" version="1">MLKNDIYKQFQLKSSTFLMAIFNLPDILILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U8</accession>
    <name>C6X2U8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807045.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02328"/>
    <dbReference type="EnsemblBacteria" id="ACU08761">
        <property type="protein sequence ID" value="ACU08761"/>
        <property type="gene ID" value="FIC_02328"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02328"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071255_0_0_10"/>
    <dbReference type="OrthoDB" id="1189912at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="269" mass="31307" checksum="513DB2F3AE1493FE" modified="2009-09-22" version="1">MLSIIISSYQQHYFDALEESIARSAGIPYEIIRIENPGKMGICEAYNKGAAAAQFENLLFLHEDTEFVTQNWGNHLLRNLSETKTGIVGLAGSTYVPNVPFAWWDHFEDTRINIIQYRGEKAVKEYQLKEPAACIVIDGVFLACRKEVWEKYPFNTQLTGFHGYDIDFSTRVASEYLNLVLSDITLKHFSEGNPDREWFNAITEYRPLFRAPARQKTNKKKELFYYLKFAQKCTQFSIRNRKRLLITYNNPKFIGYKACTKNLFKIIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y4</accession>
    <name>C6X2Y4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08797">
        <property type="protein sequence ID" value="ACU08797"/>
        <property type="gene ID" value="FIC_02364"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02364"/>
    <dbReference type="HOGENOM" id="CLU_3373901_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="34" mass="3915" checksum="E943875E1CAB6E7E" modified="2009-09-22" version="1">MVCNVWDEIFFLKTSSEQIFINPGNPPGFFYLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z4</accession>
    <name>C6X2Z4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02374"/>
    <dbReference type="EnsemblBacteria" id="ACU08807">
        <property type="protein sequence ID" value="ACU08807"/>
        <property type="gene ID" value="FIC_02374"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02374"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_0_4_10"/>
    <dbReference type="OMA" id="MFVKYSQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="252" mass="28188" checksum="8AC0718E4F183A22" modified="2009-09-22" version="1">MSKIPRGKGTTHEAAGDEFEIDQKVQRSFTEQTWDATITKDSWMVFKIMAEFVDGYEKLAKIGPCVSIFGSARLKPEDPYYEMAVEIAEKITDIGFGVITGGGPGIMEAGNKGARNGGGKSIGLNIELPFEQHFNPYIDKGFNMDFDYFFVRKVMFVKYSQGFIVMPGGFGTLDELTEAITLIQTNKIGKFPIVLVGTEFWSGLLEWFQKTLLKTGMISEADLKLYRIVDTADDAVAHIKAFYDKYTVNVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X301</accession>
    <name>C6X301_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08814">
        <property type="protein sequence ID" value="ACU08814"/>
        <property type="gene ID" value="FIC_02381"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02381"/>
    <dbReference type="eggNOG" id="ENOG5032TS9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014705_0_0_10"/>
    <dbReference type="OrthoDB" id="1247756at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="274" mass="31379" checksum="6AC5CEAEC07BF8B2" modified="2009-09-22" version="1">MRKRKGMNKEILFGTLAALLLFTNCSTDRETDEPIIEKTLLTKMTATYYDNPDNPETSVTTFNYNSKGELIDTNNSGQSSVFEYDNSGKPTKTIYYNSDKTYAYTNNYMYDGDRLTKINSVYDNPDHNRTVTYTYNTAGQVTESKLCQGQNCTSPITNTYTYSNGNILSEITQWNSIMSINTKREYTYDDKGNVYSTLNPHIRTMMGGALALSANNYKTEKISYKDASGNWNESQQINYTIEYGYAIENLPTLVTGKDQNGQLYVEYKYEYRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X311</accession>
    <name>C6X311_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02391"/>
    <dbReference type="EnsemblBacteria" id="ACU08824">
        <property type="protein sequence ID" value="ACU08824"/>
        <property type="gene ID" value="FIC_02391"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02391"/>
    <dbReference type="HOGENOM" id="CLU_3403664_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="30" mass="3498" checksum="52031EEF72A339AE" modified="2009-09-22" version="1">MNSVFLAEFFLNKIFCTHPVKWPVIGVMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X363</accession>
    <name>C6X363_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ordered locus">FIC_02443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02443"/>
    <dbReference type="EnsemblBacteria" id="ACU08876">
        <property type="protein sequence ID" value="ACU08876"/>
        <property type="gene ID" value="FIC_02443"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02443"/>
    <dbReference type="eggNOG" id="COG0611">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="179"/>
            <end position="340"/>
        </location>
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        <location>
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        <ligand>
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            <label>4</label>
        </ligand>
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            <position position="79"/>
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        <ligand>
            <name>substrate</name>
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            <position position="101"/>
        </location>
    </feature>
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        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <begin position="148"/>
            <end position="149"/>
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        <ligand>
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            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
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            <position position="175"/>
        </location>
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            <name>ATP</name>
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        </ligand>
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        <location>
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        <ligand>
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            <label>3</label>
        </ligand>
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        </ligand>
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        <ligand>
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            <label>5</label>
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            <name>substrate</name>
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            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="364" mass="40198" checksum="B323113B24A30126" modified="2009-09-22" version="1">MRRNNFFQQKNYKIMLEDKDRELTPISAYGEFGLIKHLTEKFGFDNPSTETSIGDDAAVIDPQNQKVVITTDILAEGVHFNLGYVPLKHLGYKAVVVNLSDLAAMNAIPTQILVGLAVSNRFPVEALEEIYEGIALACKRYKVDLVGGDTTSSTSGLVMGITAIGLEQSENLIKRSGAKPNDLLVVTGDLGGAYLGLQILEREHSVYLANPNMQPEMEGYDYILERQLKPEARTDIKKTLKELDIQPTSMIDVSDGLSSEILHLADQSKVGFRLYEEKIPMDSLTISTAEELNLNPVMCAMNGGEDFELLFTIAPEDFEKIRNHPDFSIIGHAVEADEGNFLVARGSNELIALNAQGWDAFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E5</accession>
    <name>C6X3E5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
            <ecNumber evidence="11">5.4.2.10</ecNumber>
            <ecNumber evidence="11">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_02528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
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        </cofactor>
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        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ACU08958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02528"/>
    <dbReference type="EnsemblBacteria" id="ACU08958">
        <property type="protein sequence ID" value="ACU08958"/>
        <property type="gene ID" value="FIC_02528"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="256504at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
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        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
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        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
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        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGM_PMM_III"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGMPMM"/>
    </dbReference>
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        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="173"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="270"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="397"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="460" mass="50217" checksum="7F683578BE413C00" modified="2009-09-22" version="1">MPLIKSISGIRGTIGGKVDENLTPLDVVKFTAAFGTWLQNNKNTKSLMLVVGRDARISGAMVNSLITATLQGLGINVIDLGLSTTPTVEVMVPELNADGGIIITASHNPKQWNALKLLNEKGEFINGKDGSDVLALAESADFDFAQVDDLGGYETRDDAFDIHIQKILDLPMVDADAIKAKKYKVVLDAVNSTGGIVIPQLLKKLGCEVVELYCEPNGHFPHNPEPLKEHLGDICELMKTEKADVGIVVDPDVDRLALVDENGELFGEEYTLVAVADYLLKHKKGVAVSNLSSSRALRDVSSAHGSEYFASAVGEVNVVTLMKEKNAVIGGEGNGGIIYPDLHYGRDSLVGVALFLTHLAKENKSVSKLRATYPSYFMGKNKIELTPDINVDLLLTKMETVYQNEDISTVDGLKIDFEKNWVHLRKSNTEPIIRIYTEALSQQEADDLGRKMIDEIKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F2</accession>
    <name>C6X3F2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02535"/>
    <dbReference type="EnsemblBacteria" id="ACU08965">
        <property type="protein sequence ID" value="ACU08965"/>
        <property type="gene ID" value="FIC_02535"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02535"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012729_2_0_10"/>
    <dbReference type="OMA" id="RYERYWH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973660" evidence="1">
        <location>
            <begin position="20"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="903" mass="102257" checksum="C27B6E7745A0B321" modified="2009-09-22" version="1">MRYFSLLFCLLFMSVLINAQTTVSGKITDADGQPVPSASVTVEEPGKDAIMAFSISNAKGEYKVTFTSPGDNVDLKIKAFNQKPLFRNIKNENQNLNFSMDFDATEIKEVKLKTRLITKKGDTITYDLKAFESKADRTLADVLKKIPGIEVNGDGSVLYQGEPINKFYVNGKDLMEGGYGTINNSLPKDAVQKVEVMENHQPVKILQDKVPSENAGLNVVLKKSVTMTGRGEVGVGMDPLLWNVKLTPMFFGQKNQWVVNYKANNNGESVEKEGNLLGFGNRWEGRRGQAGQKSWLNVETAGTPDVPEKRYLMNNVHFFSANVLTTPFKSKEWELKASGSYTNNAIERSDRKTEIYEVGSAIVPDGGTYISESSNNFYTNATKGELIITKNAKKGFFKNTTTWNGYWNDANAAIDNVLPVSGTNDVINEFGNQYLNSPSGVFQNSMSTILPWKEKLFNVMSYISYQKDRQTLDILPASYINSTGNFPQASLYERLRQNASSESFAANHSASVGFSIKKWTFTPEMGLNLNFNSIQSLLAGSNGSVFTGLGEDFRNDTEWNEVIPYTQVGVNYKSNRLNLSVNLPFTFYDITYRDRLRGTYLETGKAVLEPNLFVSLDFASFFKLWVFTGQSYDFGNFGFLYEGRMLTSPSSLTRRFNDLMPEYRTRTAGSRLEYRNPLNNLFFNVRYGYSANKRNLIEQYIGDGFNSSLSLLALENTTTSQTESVEVGKYFPDFKTNASINFSNADSTGFSYFNQLQESKVNRQNFGFKFNNTFFSWLSVDYNVTMNWVNQKNTSQNTGTKSSGWNHNLAAYIYPFQNHTIGFFWDELSTKVRNQSFNNAFYDISYQYTWAKRKIDFEIKWLNIADTDVFERVTFDPNLLLTSVSSINIRPSQVMFTVKFNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F8</accession>
    <name>C6X3F8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807255.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02541"/>
    <dbReference type="EnsemblBacteria" id="ACU08971">
        <property type="protein sequence ID" value="ACU08971"/>
        <property type="gene ID" value="FIC_02541"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02541"/>
    <dbReference type="eggNOG" id="ENOG5033EU9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493679_0_0_10"/>
    <dbReference type="OMA" id="KAYAIND"/>
    <dbReference type="OrthoDB" id="1982167at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="18843" checksum="EEBD9E4E2E5D2FB6" modified="2009-09-22" version="1">MKDFDIEKLERKNIYTAPENFFSEMQANVLQQTIPQKKGKIISLNWAYAAAAAVALIFGSTFLVGEDEPQADFVAQNAPKTEAVPVSQPKEATIAYKTLAEDLTSVTADNQKVNAAPPKTVAKAKTEKIETPRVTAPAPEVQVDQILANITSAELAVLARNVEQDVYLDLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S0</accession>
    <name>C6X3S0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosyl nicotinamide transporter, pnuC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00603"/>
    <dbReference type="EnsemblBacteria" id="ACU07058">
        <property type="protein sequence ID" value="ACU07058"/>
        <property type="gene ID" value="FIC_00603"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00603"/>
    <dbReference type="eggNOG" id="COG3201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076589_2_0_10"/>
    <dbReference type="OMA" id="WPDAYIF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01528">
        <property type="entry name" value="NMN_trans_PnuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="227" mass="26614" checksum="A6BC8BE6D7A93A5A" modified="2009-09-22" version="1">MPKIFIFGYMNLHDLFVKPYEAYETYQIILEFTATFFGVLSVYFSIKKNIWVYPTGIISTALYVYILFKFGLLGDMLINFYYTVMSIYGWFLWAKHAEDNIHVSVSRTTRKEWIVCIVLFVVSLLLVTAVYYYKPLLDTQLSAEKVILGLDHLDWANWLDVLTTAIFLVGMWLMAKRRVENWIFWIVGDLICIPMMLYKGLGITSVQYLVFTGMAILGYIEWKKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T5</accession>
    <name>C6X3T5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07073">
        <property type="protein sequence ID" value="ACU07073"/>
        <property type="gene ID" value="FIC_00618"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00618"/>
    <dbReference type="eggNOG" id="ENOG5030Z9Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1358751_0_0_10"/>
    <dbReference type="OMA" id="CFSAIIN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="201" mass="23556" checksum="095DACD8C2DB9514" modified="2009-09-22" version="1">MIRNIHKYNMKLKIYFILFLIFPLQNIYSQSNEIKIYNELFKWTFSIPDYFENVSPNESEKNQLLGKKILEQKIGKELVNKSIKIYGFKSGNYNQLVVNYQPIKSKKNFTESFKQMSEVLYETLKMELPNSVITHSYSTEVISNIKFEVFDVNITGDNKNMNMKCFSAIINGKILNVQIVDQDKEKGQALISAFRKSTFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3U8</accession>
    <name>C6X3U8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782232.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00631"/>
    <dbReference type="EnsemblBacteria" id="ACU07086">
        <property type="protein sequence ID" value="ACU07086"/>
        <property type="gene ID" value="FIC_00631"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00631"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063845_0_0_10"/>
    <dbReference type="OMA" id="IFMNLER"/>
    <dbReference type="OrthoDB" id="1217066at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972279" evidence="2">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="359" mass="42407" checksum="4B7BC9232A7A0FEF" modified="2009-09-22" version="1">MKSHLKFLILFIFFSAISFAQNNKEVALKKGSEAIKLMDAGKIEESIILLQESQKLDPENFDYPYETAYANYLKKDYKTAIEILQKLDNYKNTNAQLYTLWGNSYDNLGNPKKAIEIYDNGIKKFPNKGLLYLEKGVVYEFEKDYNKAIENYQKGISLDPKYPSNYFRMANLYLNSDDKVPGLIYGEIFLNLERTTNRTKEMSKSLYDAYKNSIVFINGEWKELNLCKNLTLDLEQYDKTKKLPLCVIYGKWFIYGLLNSNVKEINLDSLSKIRQEFIKNYFEKDNKDYPNILFDYQKQMADNNIFDAYNHYIFQMGAPEEFGEWLKTNQTEYDKFVDWYIKNENIIKPTAKNYFHATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V5</accession>
    <name>C6X3V5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782239.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07093">
        <property type="protein sequence ID" value="ACU07093"/>
        <property type="gene ID" value="FIC_00638"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00638"/>
    <dbReference type="eggNOG" id="ENOG5032WAQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249082_0_0_10"/>
    <dbReference type="OrthoDB" id="2049410at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="25787" checksum="B749F65BA6F1EE9C" modified="2009-09-22" version="1">MTVELIPVIEIGYNNQDVPTPDKYPYWDYAELWDKYNSDSYKKAGFKDEIKPYLAGSSFYRLSEITDNNLTKLVIDHTQEMRDGKYEREQASALFGGYVLRIDGHDKYFPQCCGDLSDIHYWEKLTNGKNGFYAGHPQPQVKIDADKIILDFSVNEYDEHFVPTPKDVVVSLDILPLKTAIEIAKKELETFELRIEKINRDNKLNIDKICELLIWNDENYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W2</accession>
    <name>C6X3W2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetracycline efflux protein TetA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00645"/>
    <dbReference type="EnsemblBacteria" id="ACU07100">
        <property type="protein sequence ID" value="ACU07100"/>
        <property type="gene ID" value="FIC_00645"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00645"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_11_10"/>
    <dbReference type="OMA" id="ACFSVAF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="13"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="411" mass="45190" checksum="C2AAEA5E0D72BE7B" modified="2009-09-22" version="1">MHSAMKKNQKSAAVGFIFITLLIDITGWGIVIPVVPKLIQELIHNSDLSVASKYGGWLSFAYAAMQFIFASILGGLSDKYGRRPIILFSLLGFSFNFLIQALAPTIFWLFVGRIFSGVTGASITTASAYIADVSTDEDRAKNFGMIGAAFGLGFIIGPVIGGILGQYGARVPFYAASILCLVNFLYGWFILPESLEKENRRPFNWRRANPVGSLLQLRKYPKILGLIAALVFVYIASHAVQTNWTFFTMYKFNWTETLVGISLGVSGFMAALVQGYLIRFIQPKIGNEKSIFYGLTLYAIGMVLFAFANQSWMMFAFLIPYGLGGIAGPALQSVISADVPKNEQGELQGALASLVSLTAIIGPPLMTNTFYYFTHEEAPFIFPGAPFFLGFLLMATSAVIVYRVFKNKRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W4</accession>
    <name>C6X3W4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane-associated phospholipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782248.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00647"/>
    <dbReference type="EnsemblBacteria" id="ACU07102">
        <property type="protein sequence ID" value="ACU07102"/>
        <property type="gene ID" value="FIC_00647"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00647"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_10_0_10"/>
    <dbReference type="OMA" id="FYSAHAS"/>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="60"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="189" mass="22001" checksum="69B0D666DEC9F049" modified="2009-09-22" version="1">MHEVIQEDKEIFLYLNNLGSQPFDQFWIMVSETWIWVPLYVIFLYLLYKNFGLRNVIFILIFIALGVTVSDQLAGIFKTGIARLRPCHDPSLDQLVREVKCGGQFGFYSSHASNTFFIATLMSLLLYRKHRFLPYFLFFWAAVVSYSRIYLGVHFPMDIMMGAAMGFLLGGFFATLSRKVIRDDIRHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X423</accession>
    <name>C6X423_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein HU-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782307.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00706"/>
    <dbReference type="EnsemblBacteria" id="ACU07161">
        <property type="protein sequence ID" value="ACU07161"/>
        <property type="gene ID" value="FIC_00706"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00706"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_3_3_10"/>
    <dbReference type="OMA" id="ISQEKQC"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="9809" checksum="3B4172F636B6BA26" modified="2009-09-22" version="1">MNKSELIDAMANDAGITKVAAKAALESFISNVTATLSQKDGKVSLVGFGTFSVAERAARQGINPATKKPIKIAAKTVAKFKAGADLAGSVMGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X434</accession>
    <name>C6X434_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00717"/>
    <dbReference type="EnsemblBacteria" id="ACU07172">
        <property type="protein sequence ID" value="ACU07172"/>
        <property type="gene ID" value="FIC_00717"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00717"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_10"/>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="33"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="350" mass="38964" checksum="E019E6F352CC9751" modified="2009-09-22" version="1">MQRKARTKCVRMPTFVAAKKYKTYMKYSQNILETIGNTPLVKLNKVLGEDFPALVLAKIETFNPGNSVKDRMAVKMVEDAEKDGRLKPGGTIIEGTSGNTGMGLALAAIVKGYKCIFVTNSKQSKEKCDILRAVGAEVIVCPTDVKPTDPRSYYSVSKRLAAETENGWYVNQYDNLSNREAHYEQTAPELWEQTEGKLTHFVAGAGTGGTVTGCGKFFKERNPDIKIIGVDTYGSILKEFHETGELHYDHAYTYITEGIGEDIIPENYDMTVIDHFEKVTDKDGAIYARKLAKEEGIFCGYSAGSAIAALVQMKDQFTKDDVVVVLLHDHGSRYVGKIYNDEWMAEMGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X476</accession>
    <name>C6X476_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UbiA prenyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00759"/>
    <dbReference type="EnsemblBacteria" id="ACU07214">
        <property type="protein sequence ID" value="ACU07214"/>
        <property type="gene ID" value="FIC_00759"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00759"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029423_0_1_10"/>
    <dbReference type="OMA" id="RWFLITT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="298" mass="33960" checksum="8FD79BCAF329C1E3" modified="2009-09-22" version="1">MTSRMTKFLKLLRVEQWVKNLFVFVPLFFSGNITNLDLLLKSIFAFGIFSLAASCVYILNDYSDIESDRKHPEKKNRPLASGAISKPTAIVVFVLLLLFLGVFIFLGQDYFSRDLSRFAAVIGFYFVMNLAYTFKLKHVAIVDVSIIAIGFVLRVLAGGYATGIYISQWAILLTFVLALVLAIGKRRGELINAQISGKTRRALDGYNVQFADIALSISCTLAIVCYLMFTLSPEVQQKFHSRVFYTVIFVVFAFLRYLQQTLVYNKTESPTKIIYKDRYIQVTLVLWLAAFLLQIYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L3</accession>
    <name>C6X4L3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782497.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00899"/>
    <dbReference type="EnsemblBacteria" id="ACU07351">
        <property type="protein sequence ID" value="ACU07351"/>
        <property type="gene ID" value="FIC_00899"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00899"/>
    <dbReference type="HOGENOM" id="CLU_2342631_0_0_10"/>
    <dbReference type="OrthoDB" id="2178445at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="97" mass="11048" checksum="9E3230D86FD0D0C3" modified="2009-09-22" version="1">MKSKILILDNKIHPLSTISNFLTQKKFEVVKPSETQSVFNICTMANLRAVIVDLSLFGEKSSVFLQNLTENVLPENVKLITISDRTSPRQIFDKIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M8</accession>
    <name>C6X4M8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00914"/>
    <dbReference type="EnsemblBacteria" id="ACU07366">
        <property type="protein sequence ID" value="ACU07366"/>
        <property type="gene ID" value="FIC_00914"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00914"/>
    <dbReference type="eggNOG" id="ENOG5030348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083853_2_0_10"/>
    <dbReference type="OMA" id="GIYHSRE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="194" mass="20847" checksum="D701C6CBEB61EAF0" modified="2009-09-22" version="1">MTGDNKPNINIKNFIMESQNSRPQFRNDYVSRVFRTREEADQAYTDLHGRGYSKDDINVLMSDQTRDRHFKNSDHDSELGDKVSDNAGTGSLIGGGIGAVVGALAAIGSNVLLPGLGLVIAGPLAAGLAGAGVGAATGGLVGALTNAGESEDEARTYENQIKEGGIYMGYKPRNEDDARYTYDKWYNDDTEARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q3</accession>
    <name>C6X4Q3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium/proton antiporter RosB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782537.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00940"/>
    <dbReference type="EnsemblBacteria" id="ACU07391">
        <property type="protein sequence ID" value="ACU07391"/>
        <property type="gene ID" value="FIC_00940"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00940"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020579_0_0_10"/>
    <dbReference type="OMA" id="FIFYICN"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="584"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="670"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="752" mass="83977" checksum="7E07D1DC3F408419" modified="2009-09-22" version="1">MGHLPKLIEDLALILIVAAIVVLLFRKIKQPLVLGYIIAGFLVSPNLNIFPSVVDSTNIKTLAEIGVIFLLFSLGLEFSFKKLMNVGGSASITAFVEIIFITIAGYYTGRWLGWSVMDSMFLGGMLASSSTTIIIRAFDELGVKTKNFAKTVFGVLVVEDIVVILLMVLLSTIAVTKEFEGTQILFTVAKLLFFLILWFLLGIFLIPTLLKKIKPLVDDEILLIVSIGLCLGMVLIAVNVGFSAELGAFVMGSIIAETTVAEKVEHTLKSVKDLFAAVFFVSVGMMIDYQEMMVYAWPIFIVTMLTLFGKLFSSALGALLSGQPLKQSIQVGMSMAQIGEFAFIVATLGLSLGVISDFLFPVAVGVSAITTFTTPYLIKLSEPFYNWLVKVVPPKYIKKINQYSSNTQNIQAESTWKTILKLYARILLINGIIILAIYLMFSNFIIPAINENLDSNDIKNIIGNALPVLFILPFLWALMVKRPGTVAYKELWTKTKYNRGPLLIIEITRIALGIVILGFFLDRFASTTISFFITIPVAIVFMFMFSKRLNKFYDRLEKRFITNLNDRSTNSEDAALTRLTGNTEVISNLAAWDVHIVEHQVKPLAEYVGKPLVELQWREQFGINIGYIKRGAKLIHTPDRNEVLMPYDKVGIIGTDEQFQTFRPVFDSEESVPEENADHIKLGKILINHHSVKKGLTIRESGIRDKTDGLVIAIRRGNERILNPESSEILQLDDIVWVVGNRKKIEKLNVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R1</accession>
    <name>C6X4R1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782545.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00948"/>
    <dbReference type="EnsemblBacteria" id="ACU07399">
        <property type="protein sequence ID" value="ACU07399"/>
        <property type="gene ID" value="FIC_00948"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00948"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_10"/>
    <dbReference type="OMA" id="FHIDAEI"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="307" mass="35035" checksum="917BC045BE88F38F" modified="2009-09-22" version="1">MFLELKNLTVGFKTPLINDVSTALRLGEICLLIGNNGVGKTTLIKTLLNQNPALQGEVLLETKNVRTLSNKEIAEHVAVVFSKSQIPANYTLTDLISLGKYIHYPYYFELSETDKKHVSQIIKDLDLEQFEHYPLTKLSDGNLQKAFIGRALAQNSPFIILDEPTTHLDEKNKIIILKLLRNLAKKHHKLILFSSHDWRLAKEFADKIWLINDGKLEDGITEEILLKHDDLLNPQLFNFSEGFVAPRIIAPTLEKEMLYSFLQKNCEKDISMLTFVFSESFWEVKSADSHYKFSSVGEMTELLANPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S8</accession>
    <name>C6X4S8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00965"/>
    <dbReference type="EnsemblBacteria" id="ACU07416">
        <property type="protein sequence ID" value="ACU07416"/>
        <property type="gene ID" value="FIC_00965"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00965"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_10"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="279"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="402" mass="42335" checksum="43527A94379A480F" modified="2009-09-22" version="1">MPYQKTVKYIMQEVFIVSAVRTPIGSFLGSLAGVPATKLGSAAIKGALEKINLDPNQVQEVYMGNVLQAGEGQAPARQAALGAGLSNTTPATTVNKVCASGMKAVMMASQAIKCGDQDVVVAGGMENMSLVPHYFNARSSTKLGEVKMQDGMILDGLTDVYGKVHMGVCAEKCAAENGFSREDQDNFAVESYKRSAKAWADGKFKDEVVAVEIPQRKGDPVIFAEDEEYKSVNFDRISTLPTVFQKENGTVTAANASTINDGASALILMSKDKMEELGLKPLAKIVSYADAAHEPEWFTTAPSKALPIALKKAGLEVSDIDYFEFNEAFSVVGLANNKILGLDASKVNVNGGAVSLGHPLGSSGSRIIVTLINILKQNNGKYGAAAICNGGGGASAIVIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S9</accession>
    <name>C6X4S9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782563.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00966"/>
    <dbReference type="EnsemblBacteria" id="ACU07417">
        <property type="protein sequence ID" value="ACU07417"/>
        <property type="gene ID" value="FIC_00966"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00966"/>
    <dbReference type="eggNOG" id="COG2270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_3_0_10"/>
    <dbReference type="OMA" id="WAFYDWA"/>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="498" mass="56662" checksum="D17567FE5A5261FF" modified="2009-09-22" version="1">MPENARPQTPDIKNNPKIMKAWAYYDWANSVYSLVITSTIFPIYYSILTTASEKSEYVKETGQWIKVPVRHMITVFGKDYQPDAIYGYSLTISFLIVVLLSPILSSLADTIGNKKSFLQFFCYLGATSCMGLAMFTGMQNVFLGLLFSITASVGFWGSLVFYNSFLPDIATRDKQDALSAKGYVYGYMGSVVLVVICLVLIQVFAKNPEEAKLYTRISFLLTGAWWFGFSQYTFKHLPQFGNVNNQLPKDLVLLNYKNIFKRHEEQGGFWEVLKDNISFYRDVVKESFNELFKVGKTLFADRNLKFFLSSFFFYSVGMQTIFLMATLFGKSEINLAQDRLILTLLLIQIEAIIGALIFSRLSRVIGNKNVISIAIILWIVACLSAYYLNKENPNVEYQFYGIAAIIGLVMGGLQAMSRSTYSKLLPENSMDNTTFFSFYDVLEKLAIILGTFIFATMIEQYHNMRYAALSMTVFFAAGLVLIRFLRVTVFNDKAQVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T2</accession>
    <name>C6X4T2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00969"/>
    <dbReference type="EnsemblBacteria" id="ACU07420">
        <property type="protein sequence ID" value="ACU07420"/>
        <property type="gene ID" value="FIC_00969"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00969"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_10"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="371" mass="42127" checksum="C1A5C40C7D0D4339" modified="2009-09-22" version="1">MSRDRNSNDKPKKQRISKISNSGSSRPAASRARAPKKEKPEDQKPAKEAKAREPRLLSQSEAKSYEKTFDRPVSRKPAGKRTGKSFDKSAKFVKGDGSARPTKLFKNYERPQDDGEKTRSYVQKRRLEKLSKEVPKETIRLNKYIANSGICSRREADELITQGLVQVNGAVVTEMGYQVQKTDKVIFDGQGITPEKPVYVLLNKPKGYISTTKDEKARKTVMDLVANASPYRVFPVGRLDRSTTGVILLTNDGHMTKKLTHPSFNMKKIYHVTLDRKLDRADLNAIAEGVRLEEGVAEVDSISYIEGKPKNEVGIEIHIGWNRVVRRIFQRLGYEVEALDRVMFAGLTKKNIKRGHWRILTELEVNNLKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T6</accession>
    <name>C6X4T6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monomeric-type IDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00973"/>
    <dbReference type="EnsemblBacteria" id="ACU07424">
        <property type="protein sequence ID" value="ACU07424"/>
        <property type="gene ID" value="FIC_00973"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00973"/>
    <dbReference type="eggNOG" id="COG2838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025308_1_0_10"/>
    <dbReference type="OMA" id="FRMCQTK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009407">
        <property type="entry name" value="IDH_monmr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="607"/>
            <end position="608"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="623"/>
            <end position="625"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="763" mass="83739" checksum="42F399C6ED4F5987" modified="2009-09-22" version="1">MAPVFRTPIKILKFVFFKIKKISLMSDKSKIIYTWTDEAPMLATHSFLPIVEAFAKTADIEFSPKDISLSGRILANFPEFLSEDQKVEDALAELGKLATTPEANIIKLPNISASAPQLDAAIAELQKHGYAVPNYPGEPKNAEEESIKAKYAKVLGSAVNPVLREGNSDRRAPKAVKNYAKANPHRMGSWSADSKTKVAYMTAGDFYGTEKSVTVETEGKFKIEFYGNDGSVKELKGLSPLKAGEIIDSSVMSLAALKLFVADAIAEAKAANVLLSGHLKATMMKISDPIIFGAMVEVYFKDVFTKYADLFDELDINPNNGLQDLFDKISGNSQEAQIQADIENILANGPVVAMVNSDKGITNFHVPSDIIVDASMAALIRGGGKMWNKEGKEEDTIAMIPDRNYAGFYQAAIDDMKKNGALDPRTMGSVPNVGLMAQKAEEYGSHDKTFQVSADGKVKVSDADGNILMEQEVQKGDIFRMCQTKDAPIQDWVKLAVNRARLSSTPAIFWLDDKRAHDREMIKKVEKYLKDHNTDGLDIQILNIEDAMTLTLERIRKGLDTISVSGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHIEQFIEEGYLRWDSLGEFMALQASLEHLAQTQNNTKAQILADALDVANEKFLAEDKSPARKLGSIDNRGSHFYLAMYWAEALANQTADFAIANKFKPVAQAMQENEAKINEELLGSQGKPQDLGGYYQVNKAKTDAAMRPSETLNQIIDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W1</accession>
    <name>C6X4W1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782595.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00998"/>
    <dbReference type="EnsemblBacteria" id="ACU07449">
        <property type="protein sequence ID" value="ACU07449"/>
        <property type="gene ID" value="FIC_00998"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00998"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011828_0_0_10"/>
    <dbReference type="OMA" id="NAYYHLA"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
        <property type="entry name" value="TPR_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="TPR_21" evidence="3">
        <location>
            <begin position="58"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="987" mass="112568" checksum="05CA4B3082E73925" modified="2009-09-22" version="1">MNSQKIFAAAAIFYFGISEAQQSQFFSDRENYRFSLAENLYQNKIYNASQFEYARQYFYNASLNNSQKEAAQFFDNVIGVILRKNHAEQGLEAFIKEYPNSAYFAQANLPLADYYLAQKDFDKALETLNNVNQYQLSREENTQYIMKLGYAKFMTGDSKGAMEALEEAYQNAEASDQTDIAYMLGHLYYADGQNDKAFSFFDQIKENGKYAPLVRPYYVQMYFNEQDYDKAISEGNSLLSENISADYKAEVHKIIGESYFMKGDYASAYPHLKNYLESKQNPSESDLYEMGFVAAQLKKYDEAVSYYNQLINSDSATSQNAYYQLGNAYLEVGKKQEALSAFRSAYQMNYDPKVQQLAHVQYAKLSYDIGNPFESAPTVIQGYINKYPRSSEVAEMKSLLVKSYLYSGDYQGTLSAIDKMPDSTPELNKIDQEVSFLLGTEEFNKGNFDAAEKYFLRSLEFNINKEFNTRATYWLAQTYYQKGNYPSAIVRYERILNENFAEKQQLTYDLGYAYFKSKKFAQAQKYFSEYLKNPKTEFKNDAELRLADTYYADNQLNEAIAIYDKTENADDYTLFQKAMALGFKGDTEAKISSLKSLLSKYKSSEYADDALYEIGTAYAANEDFTNANDYFSQVIKSSSDQDLVANAQIYRAQNYIDLNQNEKALTEFRALANQYKNTSYAAKVVQAARPAFMKTNDIAGYQSFAQSAGVKLDASELDEINLSSARNYYASKDYKNAIPLYEKYLTQNPTGDGLFQAQYELGESYYQSKNAAKSLLVLQEVAGVQNDYQQDAQTRIAQIYLEQNNTNEAKKYLEPLANSANVNVKNFANLELMKIYADEKNFAQAEKFADLVLSNSKNSPSITEQAKVIKARSLMNKGRDTEAKTAYAALEKSANTEVAAESLYAKAFYQNKGKAFKSSNETVFKLANNYASEEYWGAKALLLMARNYIGLKDNYQASYTVDQIIANYQDFTEIVAEAKEVKKMIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y1</accession>
    <name>C6X4Y1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07469">
        <property type="protein sequence ID" value="ACU07469"/>
        <property type="gene ID" value="FIC_01019"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01019"/>
    <dbReference type="HOGENOM" id="CLU_3310138_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="39" mass="4105" checksum="20E267CF56CF9E6D" modified="2009-09-22" version="1">MATVPEVLEGLEGLDATSPKSPRTITRCLRLSKAGDYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z5</accession>
    <name>C6X4Z5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07483">
        <property type="protein sequence ID" value="ACU07483"/>
        <property type="gene ID" value="FIC_01033"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01033"/>
    <dbReference type="eggNOG" id="ENOG5030BB4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130378_1_0_10"/>
    <dbReference type="OMA" id="CIRSFIR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="175" mass="20743" checksum="4C0F9705E438476F" modified="2009-09-22" version="1">MMIKKKIDFEARFWASYTGTCPLQVFDELFKSDPLSDTKDRLYELMHFAMKPEVFLQNDPSLVFHFYTSLKSFLRAAYVFSLKAKNWKLNEPPHYVSHVMQGSLYDDEYNVPFFAFERAFENYSLQQFEDFLTEVTYFALAPYSDHPKGNIISPFLHLQKMLDAARLIKERKTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X505</accession>
    <name>C6X505_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">L-lysine 6-transaminase</fullName>
            <ecNumber evidence="2">2.6.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Lysine 6-aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21200"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="EC" id="2.6.1.36"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.36" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805778.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01043"/>
    <dbReference type="EnsemblBacteria" id="ACU07493">
        <property type="protein sequence ID" value="ACU07493"/>
        <property type="gene ID" value="FIC_01043"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01043"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_10"/>
    <dbReference type="OMA" id="DPPDMVT"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045484">
        <property type="term" value="F:L-lysine 6-transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017657">
        <property type="entry name" value="L-lysine_6-transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03251">
        <property type="entry name" value="LAT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="443" mass="50202" checksum="2A380C9C57CB4AF4" modified="2009-09-22" version="1">MNDTVATPQTTNKVKQTLAKHMLADGFDFVMDIEKSHGSWIHDRNTGKDLLDMFSMFGSAAIGYNHPYLLERSAWLGKMAINKPTLADVYSQEFADFMDVFSRVAIPKEFQYAFFIEGGALAVENAMKACFDWKTKKNFEKGIDLEAGICIHFKQAFHGRSGYTLSLTNTSDPRKHQYFPKFDWPRITNPHLNFPLTEESLEETIQNEQRALLHIQEAILSNPDRVACVIIEPIQAEGGDNHFRDEFFTDLRNLCDDNEVLLIFDEVQTGIGITGKMWAFEHFTARPDIIAFGKKTQVCGVLANKEKFNEIPKNVFRESSRINSTFGGNFIDMLRFQLTLEVIENENLVENARIVGDYLLEGLEKLAAEFPDKISAARGRGLMCAIDLPTGAQRDELRGLLYDDGLIILACGDRSIRFRPHLNVTKEEIQIALDKISANIDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X518</accession>
    <name>C6X518_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805791.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01056"/>
    <dbReference type="EnsemblBacteria" id="ACU07506">
        <property type="protein sequence ID" value="ACU07506"/>
        <property type="gene ID" value="FIC_01056"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01056"/>
    <dbReference type="HOGENOM" id="CLU_2649165_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="76" mass="8063" checksum="CF9C6316A0F7A33B" modified="2009-09-22" version="1">MENSEIKTPRGMSVVIPGKTTTINHNLGTTDVIIALYNVATGNELNSGITVLDENSVMITTASGTPDQIRVVIMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X548</accession>
    <name>C6X548_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805821.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01086"/>
    <dbReference type="EnsemblBacteria" id="ACU07536">
        <property type="protein sequence ID" value="ACU07536"/>
        <property type="gene ID" value="FIC_01086"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01086"/>
    <dbReference type="eggNOG" id="ENOG5031DBH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574593_0_0_10"/>
    <dbReference type="OMA" id="IFVSDCI"/>
    <dbReference type="OrthoDB" id="778432at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="475" mass="53013" checksum="C4B9C1A66A9B95AF" modified="2009-09-22" version="1">MKNKTYALALFALTFIIVIYFSFSSCGGSNLIAKAGSDGVITCEEYTEIKLSILPKSRELAVLFESPGKIDDEKLKDFIINHVNIRSGSLKFNDCKEEITEVGLYLENSLSMIGYISNASDFQKNTLDLYSSLGHKNKASTYLVNRNLEPKGNIPTSGLADIISSQSKFVSAGSNISDLNKVLENVLANTKANNISIITSDFIYSLEGQNLVVVGGVTKDLFLKNSKRIKDLSVLLIQMDSQFNGLYYDMNNKPVQLSKVRRPYYYMVVGSSDMVEKFSNIIKVNKLNGFLNSYYLTSKKQEPFQKILVGTESIGRMKVDTNNPNKIELSKPVNNQVQFSIAVDLSKYPDQSKLLDAANYKISQGYKIEKIEKINPDNNPTKVNVNDWVTLKSATATHYIVVKNVGFPLKNDLILSLENNQPGWIKASSTDNDTNITQNLDKTFGLLHLVNGISDAFEQINDGDNSFFTLKYKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D6</accession>
    <name>C6X5D6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl oligopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805909.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01174"/>
    <dbReference type="ESTHER" id="flab3-c6x5d6">
        <property type="family name" value="Prolyl_oligopeptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.075"/>
    <dbReference type="EnsemblBacteria" id="ACU07624">
        <property type="protein sequence ID" value="ACU07624"/>
        <property type="gene ID" value="FIC_01174"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01174"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_2_10"/>
    <dbReference type="OMA" id="YKHWDEW"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972333" evidence="3">
        <location>
            <begin position="19"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="457"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="664" mass="75058" checksum="F3EE69DD1A5419C4" modified="2009-09-22" version="1">MKLKHTIIALAAPFLMNAQNVMTPETLWTLNKIGVTAVSPDQSSLIYSIGKTDLKTEKNNKKNYFLNIGNAESTSLDLGKKALIQWDKNGIYASEGETIFVSKDMGKTWTEFYKVGDADNIVISPDSKKIAFSKQVLVEKVLGKDKYADVPKSTAHIYTDLNHRHWDYFNEGKYNHVFVVNVSESVENANDLLEGKPWDSPQRPFGGAEDFVWSPDSSQLLYVTKPLSGDEYAQSTNTDIFAYDLASGATQNLTQSNKGYDVGPKFSPDGKSLLWMSMARDGYEADKNDVKIMDWNSRKVTNLTQNWDESVAGDVFWAQDSKTIYFSTPFRGTRQLFSLNPRNARIQQITKGDFDVTEIHAQTKNTLLVGRTDMNHNTDLFSVDVKNGVMKQVTEVNKDNYAKISPSKTELKMVKTTDGKEMGVWFIYPPNFDPSKKYPTLLYCQGGPQSALTQTFSTRWNFALMAANGYVIVAPNRRGMPGWGTEWNEQISGDWGGQVMQDYLAATDYAKTLPFVDNERIGAVGASYGGYSVFMLAGIHDNRFKTFIAHDGLFDMKSWYGTTEELFFANWDLGRPTDLPLPKAYSDFNPSNFVSKWNKPIMIIQGGLDFRVGYEQGQQAFQAAKLHGLKSKFVYFPNENHWVLNPHNALVWQREFFGWLKETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E6</accession>
    <name>C6X5E6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805919.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01184"/>
    <dbReference type="EnsemblBacteria" id="ACU07634">
        <property type="protein sequence ID" value="ACU07634"/>
        <property type="gene ID" value="FIC_01184"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01184"/>
    <dbReference type="eggNOG" id="ENOG5032TG5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093479_0_0_10"/>
    <dbReference type="OMA" id="EEHGRNE"/>
    <dbReference type="OrthoDB" id="1587286at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="200" mass="22797" checksum="71E226723BC1233F" modified="2009-09-22" version="1">MNQKIPPQKKGATTDVSSEIELATEALAAEHFKTVKKRFFAMNSWELYAGTEKAEFSLRDQDGNILLENPNKGDYFCIRTPGLHNKTGDGYDWVQIEHLEEETGDHDECVYIRVRPCDNPTKPDENIAHFFDPEATSNFLIKRKGNRIIAEVHGRNETPNTQDLNLLEKVRNEIVALGGMLIASEFQWKALTDALVKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I1</accession>
    <name>C6X5I1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01221"/>
    <dbReference type="EnsemblBacteria" id="ACU07669">
        <property type="protein sequence ID" value="ACU07669"/>
        <property type="gene ID" value="FIC_01221"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01221"/>
    <dbReference type="eggNOG" id="ENOG5033BTC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159717_0_0_10"/>
    <dbReference type="OMA" id="ENCLTIA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023162">
        <property type="entry name" value="Apc36109-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="27719" checksum="F41B8E0E39958345" modified="2009-09-22" version="1">MTTEQYDIKTNINIGQEIFENIPNDIRPGWAGLVLSRFDHYIKNIPTSISELYQIIDDKDRWKEAHEQFTKIRVFGLENKNYKPENYLRLAELVAKVTYNASGEPAPFDSDSGHYIASLALKATEYFDDNRLEEEVKSTILLFNRNKKFKDNLTAAKDFLLYKKIDDILWFDWDPIGINDIAPRDEYQGYVPEIFGLVKAKADRQEIANRLHKLEMENMGMSGTIENCLTIADKILKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M0</accession>
    <name>C6X5M0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01260"/>
    <dbReference type="EnsemblBacteria" id="ACU07708">
        <property type="protein sequence ID" value="ACU07708"/>
        <property type="gene ID" value="FIC_01260"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01260"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2990090_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="57" mass="6667" checksum="1F4B7EE173F89501" modified="2009-09-22" version="1">MVKKTNKRLLYVRYLRASGKDKDGSIAPKILFSLEECMEYIQGDEAIEVTPNFIRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P3</accession>
    <name>C6X5P3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806016.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01283"/>
    <dbReference type="EnsemblBacteria" id="ACU07731">
        <property type="protein sequence ID" value="ACU07731"/>
        <property type="gene ID" value="FIC_01283"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01283"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105320_4_2_10"/>
    <dbReference type="OMA" id="HKTEEVI"/>
    <dbReference type="OrthoDB" id="1944628at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="127" mass="13720" checksum="602BA17709F6CABB" modified="2009-09-22" version="1">MSKNRNNSAGVLAGLLAGAAAGVVLGMLYAPEEGSETRRKVKEKANELKDVAVDQYGRVSEKAKEQFQDVSGKVRDQYGNISTTVKETADKVVSSVKEGYDKYKDQAIATTTEVVKDVETELDGMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R4</accession>
    <name>C6X5R4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor, plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01304"/>
    <dbReference type="EnsemblBacteria" id="ACU07752">
        <property type="protein sequence ID" value="ACU07752"/>
        <property type="gene ID" value="FIC_01304"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01304"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353690_0_0_10"/>
    <dbReference type="OMA" id="QPPFYRE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973625" evidence="1">
        <location>
            <begin position="18"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="809" mass="92492" checksum="F190EC95C767A3F0" modified="2009-09-22" version="1">MKKIFILLAFVPALALAQINLKVLDENGAPVPEASVSYNNQTFSTDENGSVKIPVGDSEQILSVQKENFRGFSKNIRTTPKVQNINVLFVNSNRETQIEEVVFQKKGKPKVTDLTSVEITAKEAQQVASLSGGVEGLLKTLPSVNSNTELSSQYMVRGGNYDENLIYINDIEIYRPFLIRNSLQEGMSIINPDMVQAINFSAGGFEAKYGDKMSSALNIYYRQPTKFELSGEASLIGARLSTGFASKDKKLSALFSGRYRNTNLVLNTLNEDTDFNPQYMDFQAYLHYKLNPKWDFSFIGYFSKNDYEMIPKVKEVDFGSLQTPLRLSVFYNGQEDDSYKNMMGTASVSFKPNSKWSFTLDNFAYQNREREYYSIASAYLLQTFDPITGEPITSYDVGGQIDHARNDLLVKTYGTQLKTRFSPDVNTDFEVGLKFEKENLKDFTNEWQLVDSLGYSTPRDYTDPGTLDPSDLRLRFHIAGANHIQPTRLSAYAQYSKKLYWGTNRIFLNAGVRASHWDFNDETIISPRAQFAIKPDWDMDMLFNISGGIYYQAPFYKEIKDLDGNFNPDIKSQRSIQVILSHDYEFRMVDRPFKLTTEAYYKKMDHLIPYYLDNVRIRYSGQNNAEGYAYGVDTRLFGEFVPGIDSWISASYARVFENIEGRGDIPRPTDPRFRFSMFYQDYMPKFPSMRVNLTLTYANGLPSGTPVSLDENGKPDYSAPYQYQRTLPAYKRVDIGLSKVFIDQKDNRVNSGFWSNFNELTLGVQIFNAFNIQNTVANQWVNDVSSGYNYPVPVRLTGRFFNVKLEFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R7</accession>
    <name>C6X5R7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806040.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01307"/>
    <dbReference type="EnsemblBacteria" id="ACU07755">
        <property type="protein sequence ID" value="ACU07755"/>
        <property type="gene ID" value="FIC_01307"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01307"/>
    <dbReference type="eggNOG" id="COG5375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098275_2_1_10"/>
    <dbReference type="OMA" id="YWAFEKG"/>
    <dbReference type="OrthoDB" id="1736673at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972350" evidence="6">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="196" mass="22312" checksum="EA82E7429FB6B8AB" modified="2009-09-22" version="1">MNRFRKIFYSNIAGLLGCAIFFALTSCEEDLTQVNKNTNTNFPSQIINKANIVQRDSGMIKLRATAPLIEKYEYIDSPYIVAKKGINILFYDKKKPNVPGKIVAKYAKFNEKKRFYEAKGNVRITTNENQMFAMQSVFWDQGKRLIYTSDTVYVTDKDGSTLVGANGMKAKDDFSEYTFFNNSGNISAQKIPEKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U1</accession>
    <name>C6X5U1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806064.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01331"/>
    <dbReference type="EnsemblBacteria" id="ACU07779">
        <property type="protein sequence ID" value="ACU07779"/>
        <property type="gene ID" value="FIC_01331"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01331"/>
    <dbReference type="eggNOG" id="ENOG503406K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489770_0_0_10"/>
    <dbReference type="OMA" id="YRIINAY"/>
    <dbReference type="OrthoDB" id="214541at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="634" mass="70687" checksum="293BB02D1E67F8E4" modified="2009-09-22" version="1">MNNKNLLIAGFVFAGSVMHAQQGMNILEKDYEISRKAKKGYLGGVEARDNGSFDMIYFLPSSKKMVKIETYTFDKEANLTDTKKDEWELERARKRYKGLTYKGDLLINNAISVSSNLMGKLVYKNRKVTAKYNWLAGGYVRKVKMLDKQKLANENGDEYLFGGAYEVERDSAILVMGYPYSREKADFSKLDLLKVSNDGSIKKMQTITTGNQLRPVFSKPLLDDDSQNIDNDDLPRDWVLIMAPAKGSGGSPNEMTYFRISPEGVLKENIKFTTPTAGYRIINAYDKNGSVMLYGLGIKKDGKTAEELLGMSVSPSSMDAEEVEQTKSGTSATEKVLGKLGGIGGFVSAGKKAVNMVSGKEEMMPSQDDLDNAMDEKKYTDFIVCKISGGRAVFANATPIDELNGKAVAGPDMKKALTFDGKKFKTSNFQILKDGSMVLSFQDFKKNSGGVGGNKMLNTLAGIRTSSSGPKYERIYQGLYMLHFTPEGQLKKNYTVLLDQKNKKGFFNNSPMTADNFPATSYVIESKDGQSINWVIEMVKAIDKDTDFSSFMNFNGSTTNTTTTSYSPFYSIEYGKLNLAEGSSTAFRTLGDLEKKKYYLYDKYNRIQMGDYTYFFSETPNGERMLISRMDVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X1</accession>
    <name>C6X5X1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta</fullName>
            <ecNumber evidence="2">2.5.1.54</ecNumber>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="2"/>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806094.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01361"/>
    <dbReference type="EnsemblBacteria" id="ACU07809">
        <property type="protein sequence ID" value="ACU07809"/>
        <property type="gene ID" value="FIC_01361"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01361"/>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_1_1_10"/>
    <dbReference type="OMA" id="YRNIPEW"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="265"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="355" mass="39780" checksum="A912245C5C7C67D1" modified="2009-09-22" version="1">MDLKSIKNTWIENLPKPLVIAGPCSAESETQMMETARRIKETNAEIPVFRAGIWKPRTKPNGFEGVGTIGLGWLKKVKEEYGFKTATEVANAHHVAAALEADVDVLWIGARSTVNPFTVQEIAEALNGTDKPVFVKNPVNPDLALWIGALERLLGQNVTNLGVIHRGFSTYRKTKYRNTPNWQIALDFKHQFPNIPMLVDPSHICGNRTGLAGITQEALNVGYEGMIIETHCTPDEAWSDASQQITPEVLAELIANLQIRNSDISAFDDEMGRHRTLISDLDLQLIELLSHRMKISEQIGTLKKDNNIAIFQPDRWKVITEYASQKADETGMSQEFIEKLFKAIHEESIEVQNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y1</accession>
    <name>C6X5Y1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C14, caspase catalytic subunit p20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806104.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01371"/>
    <dbReference type="EnsemblBacteria" id="ACU07819">
        <property type="protein sequence ID" value="ACU07819"/>
        <property type="gene ID" value="FIC_01371"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01371"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955629_0_0_10"/>
    <dbReference type="OMA" id="CCHADGI"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="291" mass="32260" checksum="D28826254F011197" modified="2009-09-22" version="1">MEHFFALIIGVGGDLPATATDATAICSLLCDAGRGGYLNENVEFLINENATKLNILAAFDRIIAKTQPLEKATVVVYYSGHGLQIPDDNNPNQFGYYLKTSGADKARKEETMLNGSIFSEKINLLKADKILVLLDCCHADGIKNKQISAFEEMRVEETPSNRVLLEKLSGGEGRVFISACDDDEESVILPGSVNSLFTEVCLEVFNGKLSPSDEFVSVVDLIYFVVKEVPKRVLPFRHTQRPIITEVKNLSPDYFVCRNGNFIPANKDLEDFTIDNTSERLGFISSYDNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X619</accession>
    <name>C6X619_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806142.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01409"/>
    <dbReference type="EnsemblBacteria" id="ACU07857">
        <property type="protein sequence ID" value="ACU07857"/>
        <property type="gene ID" value="FIC_01409"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01409"/>
    <dbReference type="eggNOG" id="ENOG5032T97">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1822586_0_0_10"/>
    <dbReference type="OMA" id="TKRYGWG"/>
    <dbReference type="OrthoDB" id="1750102at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046155">
        <property type="entry name" value="DUF6157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19654">
        <property type="entry name" value="DUF6157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="137" mass="15683" checksum="0969EDC729999634" modified="2009-09-22" version="1">MKTHTTNYKNTFIEVAEDSPVLQSEIPPLKRNRTLANIQYEMIAANPYKYSSDDVMFECFAIKNDISEVERSEARKEFFSKGQACFRSSALGKRYGFGIHHDAEGKVALYPVESTEYERFANDESVAHVKAMRTKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X643</accession>
    <name>C6X643_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806166.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01433"/>
    <dbReference type="EnsemblBacteria" id="ACU07881">
        <property type="protein sequence ID" value="ACU07881"/>
        <property type="gene ID" value="FIC_01433"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01433"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_10"/>
    <dbReference type="OMA" id="SWNNNHY"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="417" mass="46204" checksum="1B9A81EA7FC4D034" modified="2009-09-22" version="1">MKVSKLATNLIGSEIINIGNQVNDLKSQGAEIANLTIGDLDSDIYPIPASLKEEIQKAYQNNLTNYPPANGLLSLRKAVATDLDKRWDLHYSPEEILVAGGSRPLIYATFKTIVDEGDKVVYPIPSWNNNHYSYLSHAQKTEVETSQANNFLPIAAELKPHLEGAVLLALCSPLNPTGTMFTKEQLTEICQLVLEENAKRTDGEKPLYLMYDQIYAMLTFDQQHFNPVSLFPEMKKYTIFIDGTSKCFAATGIRVGWSFGPQEVMDKMKSLLGHIGAWAPKPEQQAVSVFLNDAANVDGFVSDFKGKIEESLKVLHSGIQEMKNSGFRVDSITPMGALYLTIEIDYLGKIKPDGTPIKDSSELVFYLIEEAGVALVPFSAFGNSRNMPWFRASVGGLSTEEIRNMVPRLEKALTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X653</accession>
    <name>C6X653_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806176.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01443"/>
    <dbReference type="EnsemblBacteria" id="ACU07891">
        <property type="protein sequence ID" value="ACU07891"/>
        <property type="gene ID" value="FIC_01443"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01443"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_4_10"/>
    <dbReference type="OMA" id="PHWVWVL"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="469" mass="51806" checksum="FB6D2081A7498935" modified="2009-09-22" version="1">MQKKLKLWDGIMLVMGSMIGSGIFIVSSDMMRNLGSGYWLIAVWVITGVMTIAAAISYGELSSMFPKAGGQYTYITEIFGKMTGFLYGWGLFAVIQTGTIAAVAMAFGKFTAYLVPALNDSQPLFQSGTFKITWVQILAIVVILLLTFINTKGVKNGKLLQTVFTTSKIIALLGIIFFGFLFVKDSQWAENMSFGWNSFQDFGKEIGNDLFPTGWQGISGATLLGGIAAAMVGSVFSSVAWENVTFVSGEMENPKKNIVKSMVLGTSAVMVLYLLVNFVYLNALDRDAIAFADKNRPAVAASEVIFGNLGTVIMAVLVMVSTFGCINGLVLAGARVFQTMAKDGLFFKSAIHNNKHSVPERSLWMQGIWASVLALSGQYGDLLDMISFVIVLFYMITVLGVIYLRIKKPELERPYKTWLYPVTPILYLLIGTAFCVLLIWFKPQYTWPGFILILLGLPVYWFINRRKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X662</accession>
    <name>C6X662_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Di-/tripeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806185.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01452"/>
    <dbReference type="EnsemblBacteria" id="ACU07900">
        <property type="protein sequence ID" value="ACU07900"/>
        <property type="gene ID" value="FIC_01452"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01452"/>
    <dbReference type="eggNOG" id="COG3104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_0_2_10"/>
    <dbReference type="OMA" id="QMMGVWF"/>
    <dbReference type="OrthoDB" id="470322at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="12"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="501" mass="55416" checksum="3BC936236718A6BE" modified="2009-09-22" version="1">MATAVQTGHPRGLYLLFMTEMWERFSYYGMRAIFVLYMTRILLMDDAEASQIYGSYTGLVYLTPLLGGYLSDRFLGNRRSIEIGGILMALGQFIMFFSASTTGASAITLMWIGLTMLIIGNGFFKPNISTMVGQLYPQGDRRVDSAFTIFYMGINLGAFFAPLICGTLAEKVDFKWGFLAAGIGMVIGLVTFVIQKNKLLIDADNKPVGMPTNKFGIAQFGMVAGAIALIFFFMNFKTMFQSDLDIIGYLIYGAMVAMPLLVLTDKSLTKQERDRIMVIFILAFFVIFFWGAFEQAGASLTIFADRQTDRMLFGWEMPASYFQSVNPLAIILLAPLFSSMWLRLGNRGKEPSSPKKMAIGLALVSLGYVVIAFAVYGLGMMDKVSMFWLIALYVIHTMGELCLSPIGLSMVSKLSPLRFSSLLMGTWFLANAAANKFAGTLSALIPGSGEGGQGAKTTYFLGFEITNLFDFFLVFIVMCGAAALILWIMSRWLEKKMHGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X696</accession>
    <name>C6X696_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07934">
        <property type="protein sequence ID" value="ACU07934"/>
        <property type="gene ID" value="FIC_01487"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01487"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_41_3_10"/>
    <dbReference type="OMA" id="RYSTWKG"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="20879" checksum="49E289DC8035EFA0" modified="2009-09-22" version="1">MPFQSGLATCTNNAHLYKNAIFAALKYLKMLKIRKANPSDTPVIFDLIKKLAVYEKLANDVVTSVEELEDNIFNKNFAKVLMAEDDGKPAGFALYFYNFSTFVGKPGIYLEDLFVEPEYRGKGYGKSLLVELAKIAKEENCGRFEWSVLDWNTPALEFYKSFGAKPMEDWSVFRLDEKGIAALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A6</accession>
    <name>C6X6A6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anthranilate synthase, aminase component</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806229.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01497"/>
    <dbReference type="EnsemblBacteria" id="ACU07944">
        <property type="protein sequence ID" value="ACU07944"/>
        <property type="gene ID" value="FIC_01497"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01497"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_4_10"/>
    <dbReference type="OMA" id="HGRMDTS"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="3">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="207"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="473" mass="53849" checksum="F7785E11E6999896" modified="2009-09-22" version="1">MKFNKVIKLKTTVKSTLSDLFTPIGIYLRLRDQFRDTILLESAGNQNTDNNFSFIAVNAVAGIEIRNYTEAQIKFPLESAESINIENEKLTDLLQDFSKVFECEVPPMTIGKVAQGFFGYTSYDAVPFFEHIKFKELSPENNIPLMRYRLYQYVIAINHHNDEMFLIENKIEGLKSEMSVIENLIQQKNAPVFPFAKIGEEESNLTDEEYRNSVETAKKHCFRGDVFQLVLSRRFHQKFRGDEFNVYRALRNINPSPYLFFFDYGDYKLMGSSPESQLIIKNNQAVIHPIAGTFKRTGNIEEDLKAAEELKKDAKENAEHTMLVDLARNDLSILGKNTQVSKLKEIQFFSHVIHMVSEVTADLDKNQNPYEMIATTFPQGTLSGAPKYRAMQLIDGYEKTSRSFYGGSIGFVGFDGSCNQAIMIRTFLSRNNTLFYQAGAGIVARSIAENELQEVNNKLGALKKAIVKAEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B3</accession>
    <name>C6X6B3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806236.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01504"/>
    <dbReference type="EnsemblBacteria" id="ACU07951">
        <property type="protein sequence ID" value="ACU07951"/>
        <property type="gene ID" value="FIC_01504"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01504"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105055_0_0_10"/>
    <dbReference type="OMA" id="NAHEKQT"/>
    <dbReference type="OrthoDB" id="1425794at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13463">
        <property type="entry name" value="HTH_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="59"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="25242" checksum="48917E6B43083485" modified="2009-09-22" version="1">MELNLVIEILKELDDMQQKHPNMQMTLEDFRVHLNQKSYEKETPRNLTDKYDLDVFDLENEIAKQVIMLGRYSKQLIKKSLEKHPDLVNEDFTYLFRMMDYDSLTKMQLIEKNAHEKQTGIEIIKRLVKNGLLKESRDEKDRRSTRIAVTAKGKKVFKESMQDITIVSKIMCGQLTTKEKENLLSSLKKLNIFHDTIYNNYRNEGIDVIERLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D3</accession>
    <name>C6X6D3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806256.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01524"/>
    <dbReference type="EnsemblBacteria" id="ACU07971">
        <property type="protein sequence ID" value="ACU07971"/>
        <property type="gene ID" value="FIC_01524"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01524"/>
    <dbReference type="eggNOG" id="COG5368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023287_0_1_10"/>
    <dbReference type="OMA" id="WEMNLPI"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016883">
        <property type="entry name" value="UCP028431"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028431">
        <property type="entry name" value="UCP028431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoamylase-like" evidence="1">
        <location>
            <begin position="221"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="463" mass="51387" checksum="21477DF1796422EB" modified="2009-09-22" version="1">MKILRSLSFSIATAILFSYGSCSNEREPVVTDPPVDPPKTTVYTDPQIIEMVQKDALKYFWDFAETNSKLARERYHTDNPGLDANVVSTGGSGFGLMSILVGIKNGSVPRAEAVARLTTALNFLQNADRFHGAWPHWINGSTGKIIPFSTLDDGGDLVETAFLVQGLICVREYFKTSTEATETALSQKADALWKGVEWNWFTQGENVLYWHWSPNYNFQMNHRLQGYDETLIAYVLAAASPNYSITKDVYTQGWARNGAIKNVGSQYGIPLIVNHNGANGTVGPMFFSHYSFIGLDPRGLSDEFVNYGAATANHAKIMHQYSVANPKGWSGYSVKNWGLTASYSRNGDGTTGYAAHQPNNDLGVISPTAAISSLPYTPTESMNYLRFLYNENYSKYVGAAGPYDAYSVHYNWVTPRYLAIDQGPMAPMIENNKTQFLWNLFMNAPDVKQGLIKLGFHSSQYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F1</accession>
    <name>C6X6F1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name evidence="2" type="ordered locus">FIC_01542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806274.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01542"/>
    <dbReference type="EnsemblBacteria" id="ACU07989">
        <property type="protein sequence ID" value="ACU07989"/>
        <property type="gene ID" value="FIC_01542"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01542"/>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100552_2_0_10"/>
    <dbReference type="OMA" id="NEPYHHQ"/>
    <dbReference type="OrthoDB" id="1783583at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="124"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="157" mass="18219" checksum="90D8295A423661B3" modified="2009-09-22" version="1">MRINLVCIGKTDDKEISNLVKYYQNRLPKHWNFEITEIADVKNAKNLTPELLKKEEAKLFLAQTENSDFVVLLDENGTQFSSRGFATKIEGWMNSSVKKVSFFIGGAYGFSEEIYSRANTKMSLSKMTFTHQMIRLFFVEQLYRADQILQGKPYHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H6</accession>
    <name>C6X6H6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01567"/>
    <dbReference type="EnsemblBacteria" id="ACU08014">
        <property type="protein sequence ID" value="ACU08014"/>
        <property type="gene ID" value="FIC_01567"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01567"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066413_3_0_10"/>
    <dbReference type="OMA" id="HGNPWQF"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="302" mass="34014" checksum="0A2FD8586C2A953A" modified="2009-09-22" version="1">MFFYRKRKPGFKQRFGILNYICGMVGESHKKHFIFNWTGAFALIGGMIGGTMLVSVFNTLSIFIFHKNFQYEDYYLLIANAAGFLGAILAFDYLVARPQTGRKLNFSLSRSNLGTYLLVFPMMFGMMLIAEFITGNIPITGPFFGRYFDFFSKLMEQMTKDKATLIVLAVVMAPLFEEIVFRGIIQKGLINKGMSPVKAILLSSLVFGVVHGNPWQFVGAVLLGCVLGLVYYKTKSLLLPILLHAFNNLCSALLIFYSNTESFADAFKISDWMLLIAGLLLFAGFGYLFIKKYRVLSADPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE7</accession>
    <name>C6WZE7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Muramoyltetrapeptide carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.17.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.13" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781629.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00004"/>
    <dbReference type="EnsemblBacteria" id="ACU06482">
        <property type="protein sequence ID" value="ACU06482"/>
        <property type="gene ID" value="FIC_00004"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00004"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_3_1_10"/>
    <dbReference type="OMA" id="MLTQWRL"/>
    <dbReference type="OrthoDB" id="952832at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106415">
        <property type="term" value="F:muramoyltetrapeptide carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="177"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="309" mass="34408" checksum="8C31A641114B6CEC" modified="2009-09-22" version="1">MRTTVFPASLKNGDKIAVISPAGSVNEIQLEKGLELIKSKGYEAVLGPNLYTEFSRGYSYAGTETERISDMNWALNDSEIATVWTSRGGYGCQHLLPHIKLDGFRKNPKWYIGYSDNTAVQSYLLKKGYASLHAQTVKTSGFGVSDESYALTFDILEGKLPSYAIPNNRFNRCGSVTGQLVGGNLALIYALLATPYSFDFKDRILFIEDIGEKFYALDRMLMSLELAGVFKKIKGLIVGGMTLMEDENDNKDYEKNFDDFAYSIISERISGYDFPVLFGFPNGHIFENWPLIIGADVKVEVGDSSKITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF7</accession>
    <name>C6WZF7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="13" type="ordered locus">FIC_00014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781639.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00014"/>
    <dbReference type="EnsemblBacteria" id="ACU06492">
        <property type="protein sequence ID" value="ACU06492"/>
        <property type="gene ID" value="FIC_00014"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00014"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_10"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="151"/>
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        <ligand>
            <name>substrate</name>
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            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU06492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="342" mass="39007" checksum="576FEAFC81F16D4B" modified="2009-09-22" version="1">MIKNDLYLKALRGETVERPPVWMMRQAGRFLPEFRALRDQYDFFTRCQTPELAAEITMMPIRRYPLDAAILFSDILVVPQAMGINFEMKENLGPWLETPIRTLAQVQEVEVPNVNDTLGYVFDAIELTLHKLDNNIPLIGFAGSPWTILCYCVEGKGSKTFDVAKKFCFENPEAAHLLLQKITDTTIAYLKRKVEKGVSAVQVFDSWGGMLSPYDYQEFSWPYINQIVEALSELTHVVVFGKGCWFALEEMTLSKSSALGVDWTIRPEIARKLVGENMTLQGNFDPSRLYSSPETITRMVHEMINRFGKDKYIVNLGHGILPNIPLENAEAFIRAVVDWKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK5</accession>
    <name>C6WZK5_FLAB3</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
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        <property type="nucleotide sequence ID" value="NC_013062.1"/>
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        <property type="gene ID" value="FIC_00064"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502Z8FC">
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    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF5687"/>
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    <dbReference type="Pfam" id="PF18940">
        <property type="entry name" value="DUF5687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
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            <end position="81"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACU06540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="490" mass="55455" checksum="764755FBD3E66E23" modified="2009-09-22" version="1">MYGKLLQLEFKNFVRNPQFGANLALKILMGFAYAAMSATFFFMAVALYFVFGGKLKVDPLTLFARYFLYYAAFDMVVRYFLQQMPTQNIKPFLTQNITKKKLVNYTVLKIIFNFFNWGYLLFLLPFCALLIFHGDYSFMRVLMFLVGIMAVFYFINFLNILLNKKNSVLYGVAIVMLALAGCEYFGYIQLSEYSEIMFRTFYDLPGAFLIPLVLAGALGYLAHRNIHSTFYLDKGLELEQSVGKTENIEFLNRFGPLGTFLNNDIRLLKRSKAAKSALAAGVMFLLYGLLYFTGDAYQTVYMQVFVGIFVTGGFLLMFGQRVPAWDSSYYPLMMTQKVPYKDYLKAKWYLVVLATAVSMVLAIGYALISWEFYLTIFAAGLYNLGVNSYLTLLAGAFNKQAIDLNAAAKSFGGGKNSFNMKTVLMMIPQILVPMAVFSGVNYFAGIELAVASLGILGLLGFLLREKIFSQIVKTYNTEKYSTIEAFKKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL6</accession>
    <name>C6WZL6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4126 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ACU06551">
        <property type="protein sequence ID" value="ACU06551"/>
        <property type="gene ID" value="FIC_00075"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00075"/>
    <dbReference type="eggNOG" id="ENOG5031U0Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086377_1_1_10"/>
    <dbReference type="OMA" id="YYIPWVD"/>
    <dbReference type="OrthoDB" id="1828070at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="214" mass="22205" checksum="3006F3165962D51A" modified="2009-09-22" version="1">MLADLPFLPHIISAFIGIGLAAATGFRIFMPMFAVSLASYLGWIPVNESFAWLTGLPTLIATGIAMVAEVLAYYIPFVDHLLDTMSVPLATIAGSVMFASQFTDLGTFPQWALALIAGGGTAAAISSGFAGTRAASTATTGGLGNSVVATSETAGAGIMSFLALAAPVIAFVLAVGMVITVFIFGRKLWRKFKNGSGKQPKTIHVDAVETKNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT6</accession>
    <name>C6WZT6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome c oxidase subunit CcoN</fullName>
            <ecNumber evidence="16">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">FIC_00146</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="10">Binds 1 copper ion per subunit, denoted as copper B.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="10">Binds 2 heme groups per subunit, denoted as high- and low-spin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="16"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00146"/>
    <dbReference type="EnsemblBacteria" id="ACU06621">
        <property type="protein sequence ID" value="ACU06621"/>
        <property type="gene ID" value="FIC_00146"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00146"/>
    <dbReference type="eggNOG" id="COG2993">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017702_0_0_10"/>
    <dbReference type="OMA" id="WGWQLII"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045278">
        <property type="term" value="C:plasma membrane respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004677">
        <property type="entry name" value="Cyt_c_oxidase_cbb3_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003468">
        <property type="entry name" value="Cyt_c_oxidase_monohaem-su/FixO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF29">
        <property type="entry name" value="PTHR10422:SF29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02433">
        <property type="entry name" value="FixO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00780">
        <property type="entry name" value="ccoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00781">
        <property type="entry name" value="ccoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="14">
        <location>
            <begin position="20"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="15">
        <location>
            <begin position="564"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604677-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU06621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="763" mass="86214" checksum="6F17DB8CAEC5D1D6" modified="2009-09-22" version="1">MNNKMETQKFSYDNNIVRAFLYATVVFGLVGFLLGLIAALMLFYPELPEFFFGTDDATIVSLQSGNLQGLINSQGAFGFGRIRMLHTSAVIFAFVCNGFFAGAYYSLQRLLKTRMYSDTLSWIHFWGWQLMIVSVVITFLMGINTSKEYAEHEWPIDILITVIWVIFGINMFGTIIKRRVRHLYVAIWFYIGTWVAIAMLHIFNNLEVPLSFVGWKSYSAYAGVKDALVQWWYGHNAVAFVLTTPILGLMYYFLPKAANRPVFSYKLSIIHFWSLIFVYIWAGPHHLQYTAVPGWAQALATGFSIMLIAPSWGGMLNGLLTLRGAWDKVRENPVLKFFVVAITCYGMATFEGPLLATKTLNKIGHYTDWVIGHVHIGALGWNGFMTFGMIYYLLPIMWRTKLWSVKLANWHFWLGTLGIVFYAVPLYVAGFTQGLMWKQFNPDGTLVYKNFLDTVTAIIPYYQMRFVGGLLYISGAILMAVNVVATVRQGSFQKEVPAEAPALGNVGKKRKEGEGYHLWLERTPLIMGILSFVAVAIGGLVEIVPTLAIKDNVPTISAVKPYSPLELEGRDLYIREGCNACHSQMIRPFRDEVVRFNGKNGQYSKAGEFVYDRPFLWGSKRTGPDLHRQGGKNPSSWHYKHMLNPRVTSAGSIMPRYPWLISNDLDRSKMVAKVELMKNAFDVPYTKAQIDSADQWADNQAALIVSQIYSEAADVKKAYADKKAAEGENFTPLEKKEIVALIAYLQRLGTDIKTTEIKTASTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV2</accession>
    <name>C6WZV2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aconitate hydratase A</fullName>
            <ecNumber evidence="4">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">FIC_00162</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00162"/>
    <dbReference type="EnsemblBacteria" id="ACU06637">
        <property type="protein sequence ID" value="ACU06637"/>
        <property type="gene ID" value="FIC_00162"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00162"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_10"/>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase" evidence="14">
        <location>
            <begin position="44"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="15">
        <location>
            <begin position="569"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU06637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="768" mass="83168" checksum="B116DD023AC3F64F" modified="2009-09-22" version="1">MVFLNLNTSNMIFDFDMIQAVYARYPERIAKARETVGKPLTLSEKILYTHLWAGNATEAHERGNSYVDFAPDRVAMQDATAQMALLQFMQAGKPQVAVPSTAHADHLIQARVGAEADLQEGINKNSEVFNFLSSVCDKYGIGFWKPGAGIIHQVVLENYAFPGGMMIGTDSHTVNAGGLGMVAIGVGGADAVDVMAGMAWELKMPKLIGVKLTGRLNGWTSAKDIILKVAGILTVKGGTGCIIEYFGDGAESLSATGKGTICNMGAEVGATTSTFGYDDSMRRYLAATGRQAVVDEADKIAEHLTGDAEVYANPELYFDQVIEINLDELAPHLNGPFTPDLATPVSEFRAKAEANGWPLDVEWALIGSCTNSSYEDLSRAASIVEDAVAKGVKPKAILGINPGSEQVKFTAERDGFLDSFRKFESARIFTNACGPCIGQWDREGADKGEKNSIIHSFNRNFAKRADGNPNTHAFVASPEMVAAIAISGRLDFNPITDTLLNQNGEQIRLNEPNGFELPAKGFAVDDNGYQAPSADGTQVRVDVSPTSDRLQLLEPFEPWNGKNITGAKLLIKAFGKCTTDHISMAGPWLKYRGHLDNISNNMLIGAINAYNMETNKVKNGLSGDYDEVPNVARAYKAAGIPTIVVGDHNYGEGSSREHAAMEPRHLGVRAVLVKSFARIHETNLKKQGMLGLTFANADDYDKIFEDDTINFLDLEQFAPGRPLQLEFLHADGTKDVIVANHTYNAQQVGWFRAGSALNLIAEEAKRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZX9</accession>
    <name>C6WZX9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781811.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00189"/>
    <dbReference type="EnsemblBacteria" id="ACU06664">
        <property type="protein sequence ID" value="ACU06664"/>
        <property type="gene ID" value="FIC_00189"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00189"/>
    <dbReference type="eggNOG" id="ENOG502ZASS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_735193_0_0_10"/>
    <dbReference type="OMA" id="ARFNIYF"/>
    <dbReference type="OrthoDB" id="1124100at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="376" mass="43733" checksum="A271B5DA62E0D54C" modified="2009-09-22" version="1">MPILHPVFVTIFLFLAFASYTEIFRLEKKQRVFVWVAAILIIIAVGLRLEVGADYPVYRMLFSGFAIYTTYGDVLDKALFRPNTEEIEWIFVLINKLVFDFGLPFYIVTLIMAVIAVTLKFTTIYQNVAFPSLAILFYFMPIMFFEDSGQMRQGLGIAVCVASFKFIKERNLPMFLLCMYIALGFHKTSIVFLPAYWLVKIPMNSKRIFWVLIIALICSPLEIYRLGGDFFSTLVPPDVSGAYTGYMDDKYYGTQVETGLNDVVKFLFIVILIRWDRKGCEEVLWYEYMRNLAVFGLALFYFFRSNEIFAVRLPGAYMFFLTMFCLTNLVYAVQGRARQFLYFGFMAYFIAMFFYFGSGNGHRGGFTSDRYKNVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X003</accession>
    <name>C6X003_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00214"/>
    <dbReference type="EnsemblBacteria" id="ACU06688">
        <property type="protein sequence ID" value="ACU06688"/>
        <property type="gene ID" value="FIC_00214"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00214"/>
    <dbReference type="HOGENOM" id="CLU_3251860_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="42" mass="4864" checksum="B70976495CF44B84" modified="2009-09-22" version="1">MAGRYWAVNSAQTKNSKKVAARPEKYFIIKNMVTNKNTIFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X018</accession>
    <name>C6X018_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00229"/>
    <dbReference type="EnsemblBacteria" id="ACU06703">
        <property type="protein sequence ID" value="ACU06703"/>
        <property type="gene ID" value="FIC_00229"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00229"/>
    <dbReference type="eggNOG" id="ENOG50330PH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060694_0_0_10"/>
    <dbReference type="OrthoDB" id="1412301at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="262" mass="30025" checksum="89B63AC2975289A1" modified="2009-09-22" version="1">MNCIYCKEDISDRANFCPKCKKQIKCLKCYEIMEADSDICIICGEDKKVESSNGNTIKFRETKKTRTFEANFSNEVGQGIGEAFGLLLANKKSAGMQTKNFLKTAVNNLEYNEEGASEAIDTEYAEVPITPSKDRVFEIFNDNGGKITLLETRLKAGSKRDYSIRLAIIYLHYELVKGNAKISREKLNFIIKDASLYDGNFRRWLTNTNLIGVHEDEIELKAPGREKAKEYIDEIFNETLDDKWKLGSTPRRRKKKEEIKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X028</accession>
    <name>C6X028_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recA</name>
        <name evidence="11" type="ordered locus">FIC_00240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781860.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00240"/>
    <dbReference type="EnsemblBacteria" id="ACU06713">
        <property type="protein sequence ID" value="ACU06713"/>
        <property type="gene ID" value="FIC_00240"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00240"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_1_2_10"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="202"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU06713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="333" mass="35777" checksum="812CAD509974CDD5" modified="2009-09-22" version="1">MSSNDDKKKALALVLDKLDKTYGKGTVMTLGDASVDDSIEVIPSGSLGLDLALGVGGYPRGRVIEIYGPESSGKTTLTLHAIAEAQKAGGIAAFIDAEHAFDRHYASKLGINLDDLIISQPDNGEQALEIADNLIRSGAIDIVVIDSVAALTPKAEIEGEMGDSKMGLHARLMSQALRKLTGTISKTKCTVIFINQLREKIGVMFGNPETTTGGNALKFYASVRIDIRKASAPIKTGDEAVGSRVKVKIVKNKVAPPFKMAEFDIMYGEGVSKVGEILDMAVETGVVKKSGSWFSYEETKLGQGRDAVRDMLKDNPELSEELEAKIKEFIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X030</accession>
    <name>C6X030_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00242"/>
    <dbReference type="EnsemblBacteria" id="ACU06715">
        <property type="protein sequence ID" value="ACU06715"/>
        <property type="gene ID" value="FIC_00242"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00242"/>
    <dbReference type="eggNOG" id="COG1899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057081_0_0_10"/>
    <dbReference type="OMA" id="FWSYFCQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="403" mass="45900" checksum="89B6840FC7D6B54F" modified="2009-09-22" version="1">MAACIADTVRRKILIIIAQRVSNMTRVVWVAHSFCDCTISGHTAFGNHSDEFEYRLFKHFIHRLKLRFYKFLSLLKAKNMNKPITEFIEKYYLHFNSAALVDASKGYVAHLKDGGKMMITLAGAMSTAEIGKILAEMIRQDKVDIISCTGANLEEDLMNLVAHSHYERVPHYRDLTAQDEWALLERGLNRVTDTCIPEEEAFRRLQKHIVEIWKDAEAKGERYFPHEYMYKMLLSGVLEQYYEIPKENSWMLAAAEKNLPIVVPGWEDSTMGNIFSSYCIKGELKASTMKSGIEYMMYLADWYPKNSGGKGVGFFQVGGGIAGDFPICVVPMLYQDMEMTDIPFWSYFCQISDSTTSYGSYSGAVPNEKITWGKLDITTPKFIVESDATICAPLMFSYILENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X057</accession>
    <name>C6X057_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ordered locus">FIC_00274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781889.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00274"/>
    <dbReference type="EnsemblBacteria" id="ACU06742">
        <property type="protein sequence ID" value="ACU06742"/>
        <property type="gene ID" value="FIC_00274"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00274"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_6_0_10"/>
    <dbReference type="OMA" id="LAIWGVD"/>
    <dbReference type="OrthoDB" id="1974284at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="67" mass="7516" checksum="C08B8D209002EA5A" modified="2009-09-22" version="1">MSLVDFIKGSYIEFKDKVEWPKWPDLQSSTIVVTIATVILALFVFGVDSLFSKAIANMISLFIGIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X060</accession>
    <name>C6X060_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplA</name>
        <name evidence="10" type="ordered locus">FIC_00277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781892.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00277"/>
    <dbReference type="EnsemblBacteria" id="ACU06745">
        <property type="protein sequence ID" value="ACU06745"/>
        <property type="gene ID" value="FIC_00277"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00277"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_10"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="230" mass="24607" checksum="74DC5F37C7CD108E" modified="2009-09-22" version="1">MAKLTKKQKEAVSKIEKNKIYNLEEASALVKEVNFAKFDASVDIAVRLGVDPRKANQMVRGVVSLPHGTGKDIKVLALVTPEKEAEATAAGADYVGLDEYLQKIKEGWTDVDVIVTMPAVMGKLGPLGRILGPRGLMPNPKSGTVTMDIGKAVAEVKAGKIDFKVDKYGIIHAGIGKVSFDAAKIKENAQELVQTLIKLKPTASKGVYVKSIYLSSTMSPGIAIDTKSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D0</accession>
    <name>C6X0D0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781962.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00348"/>
    <dbReference type="EnsemblBacteria" id="ACU06815">
        <property type="protein sequence ID" value="ACU06815"/>
        <property type="gene ID" value="FIC_00348"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00348"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_3_3_10"/>
    <dbReference type="OMA" id="CMAQIGL"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="148" mass="16419" checksum="263FDD2037479DA4" modified="2009-09-22" version="1">MSITANILQQLPFSEPYLFVDELHYVNDEGASGSYTFRRDLPFYQGHFKDAPVTPGAILIEVMAQIGGSSLGIYLSSQENGGQNPPQLCLASSYEASFFLPVYPGERVTVVSEKVYFRFNKLKFKVQMVNSSGSIICRGVFTGMLKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M5</accession>
    <name>C6X0M5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782058.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00449"/>
    <dbReference type="EnsemblBacteria" id="ACU06911">
        <property type="protein sequence ID" value="ACU06911"/>
        <property type="gene ID" value="FIC_00449"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00449"/>
    <dbReference type="eggNOG" id="COG3508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053101_0_0_10"/>
    <dbReference type="OMA" id="PYNHSNI"/>
    <dbReference type="OrthoDB" id="193687at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="395" mass="45958" checksum="A1ADA5EC549300D1" modified="2009-09-22" version="1">MRYHHSGKIPQKRHTVFKSDEGKFYYEQLFGTEGFHGISSLLYHIHRPTQIKSISEPKDVTPKIAVEKNVTPRMFKGMNVAAEDDFLDSRKILMLNNDLKMGLAKPRRSTEYFYKNAECDEMLFVHEGSGILKTFVGNLEFSVGDYLIIPRGTIYQLEVFTENNVFLIVESHSPIYTPKRYRNEFGQLLEHSPFNERDIITPTFVAPKDEKGDFLIKVKKENQIWDFIYATHPFDVVGWDGYFYPFKFNIKNFEPITGRVHLPPPIHQTFEAHNFVVCSFVARMYDYHPLAIPAPYNHSNIDSDEVLFYTEGDFMSRNHIDLMDFTLHPGGIVHGPHPGAMERSIGKKFTEEFAVMVDPFRPLKLTEEALKVEDPTYKTSWIETDENHLEDRSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N5</accession>
    <name>C6X0N5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PpiC-type peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782068.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00459"/>
    <dbReference type="EnsemblBacteria" id="ACU06921">
        <property type="protein sequence ID" value="ACU06921"/>
        <property type="gene ID" value="FIC_00459"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00459"/>
    <dbReference type="eggNOG" id="ENOG502ZA3N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448158_0_0_10"/>
    <dbReference type="OrthoDB" id="255573at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973548" evidence="1">
        <location>
            <begin position="20"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="609" mass="69624" checksum="93E8359345676239" modified="2009-09-22" version="1">MKKLFVLTVLLSLSITLQAQYFIIGKDSISLADFKREYQYGLQNNGITKTLQSTEDFILLQQFAAEKKADTAAAFREKMMVREGELREQFFYPKHIIDPLLEAYMKDNLTEKEVQIFLVPKTEGDANNYKQIYADVVAGKLKMEDALTKYTKNSPNPVHIKPGSADNALYDALKVLPNNTFTNLMDLPGYIAFAKVLNSRPSLGYMIFGTISYPKDENSEATKTKIYTDLKAGKTFQQVAKLYGANDHEKDNGGVVMGSPTLPAEVYAAFKGQKSGYYTPEPILFGDKYFVFNIYNVEPYALNDKNRDFFLKDMNASLYGEKLQDKMIAFLKSDPSYKEFPEFQQMKKSYQTLATAKDNTPLYAYKNRKVTVGDIKTLIGDKKSDAEKLTPALWAEALGSVNSGHLLSYYSEDFAQQKDIKKELTEFRKGLFSDYVFSKYINEEITKHPEWLTDYYNKNKSKYMWGNRADGRVAIIADDNLTKEIVKDIKNPKNWEALTAKYYGKLNDKKQIIVHFEKGEMSEDADVFTKYKVPFKTGVHQTKMEQRTLVIAIEKILPPMQMTQEEAAELLKDAVTEEKLREIIAQQKAKTQITVQPAFSADLDKNFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0U5</accession>
    <name>C6X0U5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01612"/>
    <dbReference type="EnsemblBacteria" id="ACU08058">
        <property type="protein sequence ID" value="ACU08058"/>
        <property type="gene ID" value="FIC_01612"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01612"/>
    <dbReference type="eggNOG" id="ENOG502ZEQ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198056_0_0_10"/>
    <dbReference type="OMA" id="IDEAIFW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="257" mass="29783" checksum="81628BE383C50AA2" modified="2009-09-22" version="1">MVKFAQMQLLNLVKKYVIDSQVYVSLMGTALAVFFMLEQNVLRWPTVLLIFITYFSGYLYTKYQRHRFFPKILIFNVICGIISMVLIFHNHNEIRLLKWLVIVTLGLLYNSFFLENFIRKIPLLKVFYVGFTWALVNSWLILPEFNPGIFIITLLFITALVLPFDIRDMRSDDIVTFPRLIGVVKTKLVAYALTVASALTAFVSLETEFAAAFLMTAFVSCVLIYFSDNKRPDAYFSFGVETMSSLPFLIIVLLKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0V5</accession>
    <name>C6X0V5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01623"/>
    <dbReference type="EnsemblBacteria" id="ACU08068">
        <property type="protein sequence ID" value="ACU08068"/>
        <property type="gene ID" value="FIC_01623"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01623"/>
    <dbReference type="HOGENOM" id="CLU_3061772_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="53" mass="5832" checksum="51C42053513EF6D7" modified="2009-09-22" version="1">MENSNRNKPGKFMIAAIALLILVIISYLVVIQLFPNFFMTLPSGAAQPVDARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0W9</accession>
    <name>C6X0W9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitellogenin II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806367.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01637"/>
    <dbReference type="EnsemblBacteria" id="ACU08082">
        <property type="protein sequence ID" value="ACU08082"/>
        <property type="gene ID" value="FIC_01637"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01637"/>
    <dbReference type="eggNOG" id="COG5164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808625_0_0_10"/>
    <dbReference type="OMA" id="WNNGFGW"/>
    <dbReference type="OrthoDB" id="1851257at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972194" evidence="2">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="311" mass="34759" checksum="41D3A415AC3FFD96" modified="2009-09-22" version="1">MEKITYKNILLAIKSKVVLAVAGGLVLASCTTQMGGYTETDGVYYDPSRDTLPEGSMTRNTNQVGDYYDYQANDDANVYLNVDNRNERWREAQSSDWGSYQGTDTYYSDNWGYPYSYYGGFGFGMSFGWGSPWGYGGYYNPWGFGYNPWYSYYSPYYGYYNHYFGYNPYYGYGYGAPYYGIGNGYNSYNGGFVNKRSGRTGSITNSFRNSNGTLRNSSSSDSGFRNNGTNTYQNNNNGFRQQNSNQPRLRNSQPTSPRQSMPRQTAPTYSEPRYRGNSNDGGGFRSGSSSGGFNSGSSSSGSTRSSGGFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y1</accession>
    <name>C6X0Y1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806379.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01650"/>
    <dbReference type="EnsemblBacteria" id="ACU08094">
        <property type="protein sequence ID" value="ACU08094"/>
        <property type="gene ID" value="FIC_01650"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01650"/>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019348_2_0_10"/>
    <dbReference type="OMA" id="RNQVIYD"/>
    <dbReference type="OrthoDB" id="1114630at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972196" evidence="1">
        <location>
            <begin position="19"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="360" mass="40685" checksum="126AE5C57582E7FA" modified="2009-09-22" version="1">MKNSISLFLAVFMLNLFSAQIPTGYYSQANGLTGYTLKTKLKEIVTNGHQDNGYNGLWNAYKVGDLDKFYENDNTILDIYSEKPLSADAYNYTPGANQCGNYNAEAVCYNREHLFPQGFFDEAFPMKNDYLHIMPTDGYVNGKRNNFPFGTVGAASWTSTNGSKLGTSNFPGYGGTVFEPINEFKGDIARSLLYFITRYEDKLQEFDYDDANNPQDGSKNRGFDQWYINLLLQWHQNDPVSPKEIARNNYAYTYQKNRNPFIDHPEYVTLIWTSTLATESADLTENVLRISNNPVRNGELTVNGKNITTIASAQIISAAGQVVQTLKEPFKNSNKIILNNKTKGIYFLKTEGQSVKFIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X127</accession>
    <name>C6X127_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01697"/>
    <dbReference type="EnsemblBacteria" id="ACU08140">
        <property type="protein sequence ID" value="ACU08140"/>
        <property type="gene ID" value="FIC_01697"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01697"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_2_1_10"/>
    <dbReference type="OMA" id="VKWDERF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="141" mass="15843" checksum="568317A8B419627E" modified="2009-09-22" version="1">MRTMAQILAVDYGKARCGIAATDDFQIIASGLDTVETKNIFTFLAGYFAANNVELVVVGLPTDLKGNLSSIETDIAKFLEKFKTQFPTVKTERFDERFTSKMASFYISQSGKNKKKREEKGLIDKVSATLILQNFLEQKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X134</accession>
    <name>C6X134_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806432.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01704"/>
    <dbReference type="EnsemblBacteria" id="ACU08147">
        <property type="protein sequence ID" value="ACU08147"/>
        <property type="gene ID" value="FIC_01704"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01704"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045463_0_0_10"/>
    <dbReference type="OMA" id="QHFLVGS"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="323" mass="34853" checksum="8B9838C6661C0B82" modified="2009-09-22" version="1">MKKLAICILFVGCAAVLPDEPTARIEFNAPEAYPEGIAYDSISNVYYVSSARFGSVGKVTPQGAYTSLISDPGFKSSYGLKIHPDGKRVFACISDANYSKFTSPDTRKKMARLIGIDMATGKVTDDINLAGLIPGEHFANDLIFDNQQNAYVTDSFANVIYKVTPAGKASVFADSPLFKTKGIGLNGIVYHPSGYLLTVSSGTGAIYKVDIANPKNVTKLATEQFFINGDGLLLTANDKLIVVQNGGSDKIYELTSNDNWASAKLTASTLVADRFTYPATATKAQDKVWIMNAKFSELTDSTSVPSKKFAIQHARLMPLPRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X160</accession>
    <name>C6X160_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806458.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08173">
        <property type="protein sequence ID" value="ACU08173"/>
        <property type="gene ID" value="FIC_01730"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01730"/>
    <dbReference type="eggNOG" id="COG3809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147819_0_1_10"/>
    <dbReference type="OMA" id="KSIWHEL"/>
    <dbReference type="OrthoDB" id="1847417at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="91" mass="10749" checksum="1D04FF423FFFF1B7" modified="2009-09-22" version="1">MKCPNCNVSLVMTDRSGIEIDYCPDCRGVWLDRGELDKIIERATPENPAAPQQQFQQQQHQQSYSDRRDYSRNDDYRYKKKKGLLGELFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X170</accession>
    <name>C6X170_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Mannonate dehydratase</fullName>
            <ecNumber evidence="5 6">4.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-mannonate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxuA</name>
        <name evidence="7" type="ordered locus">FIC_01740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="5 6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806468.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01740"/>
    <dbReference type="EnsemblBacteria" id="ACU08183">
        <property type="protein sequence ID" value="ACU08183"/>
        <property type="gene ID" value="FIC_01740"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01740"/>
    <dbReference type="eggNOG" id="COG1312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058621_2_0_10"/>
    <dbReference type="OMA" id="AIVKAYH"/>
    <dbReference type="OrthoDB" id="907794at2"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00106">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00695">
        <property type="entry name" value="uxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="390" mass="44334" checksum="6B1CCF8F4513027B" modified="2009-09-22" version="1">MEKTWRWFGKNDKIKLDMLRQIGVEGIVSALHDIPNGEIWPLDAIEDYKNHIASYGLRWSVVESLPVSESIKYGGEDRDQLIGNYIKSLENLGKAGVKTVCYNFMPVLDWARTDLYYQWEDGSSSLYFDKAKFAYFEIHILKREGAEKDYAEEILAKVEELKNTLTETDNNELIDAIIVKTQGFVNGNIKEGDLNPVEKFKNLLSLYRGIDKNQLRENMKYFLENIMPVCEQYDIQMCVHPDDPPFALLGLPRIVTCEEDIDWFLNAVDNPHNGLTFCTGSLSAGLHNDVPALAKKYASRTKFVHLRSTNVFGNGDFIEADHLSGRGKIVEVVRVFEKENPSLPMRVDHGRLLTDDIDKGYNPGYSFLGRMLALGQIDGVMAAVKSEFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X193</accession>
    <name>C6X193_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M4, thermolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01763"/>
    <dbReference type="EnsemblBacteria" id="ACU08206">
        <property type="protein sequence ID" value="ACU08206"/>
        <property type="gene ID" value="FIC_01763"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01763"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511835_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011628">
        <property type="entry name" value="Cleaved_adhesin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07675">
        <property type="entry name" value="Cleaved_Adhesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972203" evidence="1">
        <location>
            <begin position="19"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="195"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="288"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="635" mass="66819" checksum="9AAE0BAB3DCA5F5C" modified="2009-09-22" version="1">MKKILLSCFLALGMSATAQTYFSDNFNDEDVSNWTRIDQDGDGKNWADIFVVPDAAGNPSTPVSLISRSWQVTPLTPDNWIVSPAIDLSTAAGKDVMLNWKVLAAAAAWDNENYSVYVATASDIASLTASPVKFSETYDDPADAGTQYSRTLDLTSFAGQTVYVAFRHHGVTDMDFISIDDVVVKSPDTVAPNCPTLTLPANAATGVSIAPTLTWTAPSTGASADSYDVYFGTTANPTALLRNVTTTSTAVTGLAASTTYYWRVVAKNAIGSATGCTEFSFTTKAAAPPGCATLVAPLNAAVNVAYPTRLTWTAPTTGGAPTGYDIFLGSSPTTLANLGSTAALSVNITGLLKDTTYYWSVVPKNADGSATNCAVYSFTTVNDYCGPLTYGTVEATTYVNLTHNTANTSPVTAAPAHEYFLSKTFKAEKGANTTITLNANTGGDFRHFFAVFIDWNQDGDFNDANEKYFTTSTSFLSILNSTGITTNNHVTGTIAVPADAPLGVTRMRIKSAFYGATGPAAGTTLTNFADACVTTGSSYGQVEDYNLEVVSAGTLAASDVTKSAVSVYPNPFSDVLNISDVKGVKSVSITDVAGRQVKSMKASAQLNVSDLKTGLYIVTLHMEDGTVKSVKAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D7</accession>
    <name>C6X1D7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806535.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01807"/>
    <dbReference type="EnsemblBacteria" id="ACU08250">
        <property type="protein sequence ID" value="ACU08250"/>
        <property type="gene ID" value="FIC_01807"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01807"/>
    <dbReference type="eggNOG" id="ENOG5032UBY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137390_1_0_10"/>
    <dbReference type="OMA" id="KWNRAAI"/>
    <dbReference type="OrthoDB" id="2016615at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021866">
        <property type="entry name" value="SpoIIAA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038396">
        <property type="entry name" value="SpoIIAA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11964">
        <property type="entry name" value="SpoIIAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="13973" checksum="7E04302456B9F5C6" modified="2009-09-22" version="1">MITLIPDVPENVAAFRASGEITKEDFEKLVMPHVAAKVNTFKELNYLLLLDTDLDKFTAGAWMQDAFLGLQNLTKWNRAAIVTDKNAVKKFTDAFSVVMPGEFRGFGKEDLASAIYWCAHGKTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E2</accession>
    <name>C6X1E2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08255">
        <property type="protein sequence ID" value="ACU08255"/>
        <property type="gene ID" value="FIC_01812"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01812"/>
    <dbReference type="HOGENOM" id="CLU_3356320_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="36" mass="4044" checksum="84688FAD8F541212" modified="2009-09-22" version="1">MTFGGIGSAEKFAVGCSLKKMYFAWLKPPYESKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F9</accession>
    <name>C6X1F9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="2">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">asnS</name>
        <name evidence="4" type="ordered locus">FIC_01829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01829"/>
    <dbReference type="EnsemblBacteria" id="ACU08272">
        <property type="protein sequence ID" value="ACU08272"/>
        <property type="gene ID" value="FIC_01829"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01829"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_10"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="3">
        <location>
            <begin position="152"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="498" mass="57210" checksum="BF5056F8A94637CD" modified="2009-09-22" version="1">MSGRNHRVSTIKKLMPAMRTTINELLSDYKKLLHHDITVQGWVRAFRSNRFIALNDGSTINNLQIVVDFEKFDEDTLKNISTAASLKIVGEVVESQGAGQSIEIIARKIIILGDNFTEERDKTILQPKKHSLEILREQAHLRFRTNLFGSVFRVRSAVSFAIHQFFNKNQFFYMNTPIITGADAEGAGEMFSVTNFDINDLPKDENGEIDYSQDFFGKKTNLTVSGQLNVETAMMGLGRVYTFGPTFRAENSNTTRHLAEFWMVEPEVAFNNLEDNIDLAEDFLKYVIGYVLENCKDDLEFLDKRFAEEQKQKPEKDRASEGLIEKLQNVIQKRFKRVSYTEAIDILKNSKENKKGKFQFPIEEWGADLQSEHERFLVEKHFESPVVLFDYPKEIKAFYMKLNEDGKTVAAMDVLFPGIGEIIGGSQREDKFDVLTEKMKAMNVDEHELWWYLDTRKFGSVPHAGFGLGLERLVLFVTGMTNIRDVIPFPRTPNNAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G2</accession>
    <name>C6X1G2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806560.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01832"/>
    <dbReference type="EnsemblBacteria" id="ACU08275">
        <property type="protein sequence ID" value="ACU08275"/>
        <property type="gene ID" value="FIC_01832"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01832"/>
    <dbReference type="eggNOG" id="COG0833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_4_10"/>
    <dbReference type="OMA" id="SINSWIA"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="459" mass="50582" checksum="FE4C5C5A96CD0921" modified="2009-09-22" version="1">MDKNPQLEAKYGLFTAISMVIGQVIGSGIFFKVDDVLVATQGNILAGLLGFIIVGVSVVFGAISMANYAEVLPKDGGVLNYVNFRFGETASYFVGWMYMVLFYPLLTAVLFTVSGIYIAHLCAEFMAFEPTPLHFMLIGSVNLLIFFAFNIFRPKSSGIFQQLTMVLKVLPLIFIASLGILSLVKGDVEEANTFAYAAKNVSDNQTFLLLIAASFVPISFAFDGWYIATQISGEIKNSRKNLPKALIIGTVAVTVIYVSYYMGIVFRISGDQIIRLKDTYITEFSRKIAADSGALIMQLFIIISVLGAANGLLLATIRVPFQFSNLPKSKKVLNLDVINQKTRMPVNSALLGLALIAIYLLIYYETNSNAFFVSRIFDLSAIPIVFIYLVNGALFIGLFRLFRKNVFTGNKILKIVMTVIAIFGIVVVLLGTFSSPNGLTYLWISVAFLLMGFLMKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H8</accession>
    <name>C6X1H8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806576.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01848"/>
    <dbReference type="EnsemblBacteria" id="ACU08291">
        <property type="protein sequence ID" value="ACU08291"/>
        <property type="gene ID" value="FIC_01848"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01848"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_10"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="29442" checksum="2E204A8B0C9A61C0" modified="2009-09-22" version="1">MKDSQHSHKPESGQAEPNKKDDFIFGLRPVIEAIEAGKTIDKIFMQNALQGDIYYELKTLLSKHNIRPNYVPIEKLNRFTRKNHQGVVAFISDVPFESIQDVLPQLFEEGKTPFLLILDRLTDVRNFGAICRTAECVGVHAIILPEKGAAPINSDAIKTSAGAIYNLRICKEKNLAHAVDFLQQSGLQVFSASEKAQKLIYDVDFTQPCAIVMGNEETGISKEVLHHSDEKIKLPIEGKTQSLNVSVACGAILYEAVRQKLSTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J6</accession>
    <name>C6X1J6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806594.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01866"/>
    <dbReference type="EnsemblBacteria" id="ACU08309">
        <property type="protein sequence ID" value="ACU08309"/>
        <property type="gene ID" value="FIC_01866"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01866"/>
    <dbReference type="eggNOG" id="ENOG5033BNR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1552571_0_0_10"/>
    <dbReference type="OrthoDB" id="2084609at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973341" evidence="2">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="204" mass="22171" checksum="8EFE9D999C22FBBB" modified="2009-09-22" version="1">MIYKLLLSTFSILTLATCQNQTMTEKNLTTSADTENTTHATPTPPKTAEPEMSVGLPPDSAAVELSKQEQANAAKNTAGVIYLKEGENKFLKEYEMNVTFKKMTEDSRCPEGVNCVWEGVAVAEVELMGLATRPVTVRLSTMNDAKKGHTKTQDFNGHSVSLVEVTPNTTSSKGFKSIAGNYRIGIKITKGMSGNTSDQRTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K0</accession>
    <name>C6X1K0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01870"/>
    <dbReference type="CAZy" id="PL10">
        <property type="family name" value="Polysaccharide Lyase Family 10"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08313">
        <property type="protein sequence ID" value="ACU08313"/>
        <property type="gene ID" value="FIC_01870"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01870"/>
    <dbReference type="eggNOG" id="COG4677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392248_0_0_10"/>
    <dbReference type="OMA" id="AYFENCE"/>
    <dbReference type="OrthoDB" id="1095798at2"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012669">
        <property type="entry name" value="Pectate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09492">
        <property type="entry name" value="Pec_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02474">
        <property type="entry name" value="pec_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125656" description="Pectinesterase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase" evidence="4">
        <location>
            <begin position="364"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="657" mass="75169" checksum="1D18569B41EBF066" modified="2009-09-22" version="1">MQMKNCFLLFIVLFFSLQNLAAQTPEKDWSKIAFTKDENLLKSADAERIAENILLYQKSNGGWGKNVAVQKQLSADEKKKIEAAKGDLKVTTIDNKATVQELTFLANVYRFHKKDEYRDAFLRGLGFLLEAQYENGGWPQFYPVQNNYSSHITFNDDAIARVLIFFKRIIDEGPAFPVEIPAQTLAEINTSFQKGIDIILKTQYRQNGKLTVWGAQHDEYNLLPTKARAYELPSLTAKESATLVLLLMSLEKPSKDVISSVEKAVKWFEQNQLKGYKEIEISGDKKLIADAAAPPMWGRFYDLENNQIFVSGRDGEKKKSYDEIEAERRNGYAWYTYEPAKVLKKYEAWKKKHVKIIPDKAQYTVSKDGSADFESIQDAVDQLKSFPDQRITLFIKNGKYEEKVKIHQWNTNIKIIGEDREKTIITFNDSFADIDKGRNSTFYTPTLSIEANDIILENLTVKNTARETGQAVALSITSDRVAVFNCKLRGNQDTLYVGNEGKIYIKDSYIEGTTDYIFGGATAYFENCELHSKKDSYITAPSTPEGSEFGFVFNKCRLTAAENVTKVYLGRPWRTYAKAVFLNTNLSSAIAPEGWHNWNNSSAEKHVLFAEFQNFGEGFRPDFRVKWSNQLSKRQAKKYTKQNVLKTDINTNWYENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L9</accession>
    <name>C6X1L9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pectin degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806617.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01889"/>
    <dbReference type="EnsemblBacteria" id="ACU08332">
        <property type="protein sequence ID" value="ACU08332"/>
        <property type="gene ID" value="FIC_01889"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01889"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134269_1_1_10"/>
    <dbReference type="OMA" id="THSHPNE"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025499">
        <property type="entry name" value="KdgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029883">
        <property type="entry name" value="KdgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="108" mass="12030" checksum="B08E6551DECB2D1B" modified="2009-09-22" version="1">MFFKTAENAWEKVGDGIERQIVGHDDTLMIVVVRFKKGSVGALHQHFHSQATYIAEGKFEVTVENETVILGKGDSFFITTNKIHGVVCLEDGVLIDSFSPAREDFLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M8</accession>
    <name>C6X1M8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaminyl-tRNA synthetase</fullName>
            <ecNumber evidence="5">6.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01899"/>
    <dbReference type="EnsemblBacteria" id="ACU08341">
        <property type="protein sequence ID" value="ACU08341"/>
        <property type="gene ID" value="FIC_01899"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01899"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_10"/>
    <dbReference type="OMA" id="INNFCAQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="3">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="4">
        <location>
            <begin position="280"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="496" mass="58127" checksum="D4FAE632D96330B9" modified="2009-09-22" version="1">MNLRFDDTNPEKEEQEFVDSIKADIDWLGFKYDKELYASDYFGQLYQWAVEMISEGKAYVDEQSSEEITAQRKNPFEDGIDSPFRNRPVSESLELFEKMKNGEFEEGSMSLRAKIDMKSPNMNMRDPVMYRILKRPHHRTGEQWKIYPMYDWAHGESDYIEQISHSLCSLEFENHRPLYDWYLDQVYDENLVRNKQREFARMNVSYMITSKRKLQRLVAEKAVTGWDDPRMPTISGMRRLGYTPTAIKNFIERVGVAKRENLIDIQLLEFFVREDLNKTATRVMAVVDPVKLIITNYPEDAEEFLETENNPEDENAGTREVPFSRELYIEREDFKEEGNKKFFRLKLGGEVRLKSAYIIKAERVDKDENGEITTIYATYDEKSKSGSGTEETVRKVKGTLHWVSAKHALPIEVRIYDRLFTTPQPDAEKETDFMEFINPESLKTVEGFAEPSLASAKLGLNYQFQRIGYFTKDRDSTPETLVFNRTVTLKDGYKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T8</accession>
    <name>C6X1T8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806686.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01959"/>
    <dbReference type="EnsemblBacteria" id="ACU08401">
        <property type="protein sequence ID" value="ACU08401"/>
        <property type="gene ID" value="FIC_01959"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01959"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556378_0_0_10"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="490" mass="56035" checksum="01514A079B0A18C0" modified="2009-09-22" version="1">MKYLYFILSICWILSCSDRELSPTESNPKVEVNQPPSPVKFTIDSISHNGAHLSWEAASDPESDELSYSIELDGKLVLERAKDRTYKFQNLDELTTYSGKIIVTDAHKNTTSTSFSFQTKKFYLTFVKNYLFPGATLTSGAPYNILKLSDGNYLVGGYVSAGTYFYIVFLMKTDYYGNIIWKKNYDIAGESSPFTFIMKEIQGEIILAASYTVAKLNLDGIQKWEKRITTYDNGYGDSTINSFATDADHNIYIVGTLADTTDESAEMGMITKLTPDGQLIWEKKYTSYITETGNKTMYLRFMDIDIKGDQIYILGDIDVSGMDTNSNMVKQVFYFLKTDTDGRSLSEKAYNHHNNLSHKILRRKNGNYLLSSQQSIVEIDQSGNEVWAKTYYAVTQMYSMFYSFKETASGDLVFVGKEDKLGVYFRTDNRGNMLYKKYYNSLPNYAAGIDVVLEDDQSYRIAFAFGRYYSFNLWYDEIMLVKTDTEGNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X249</accession>
    <name>C6X249_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ordered locus">FIC_02075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806796.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02075"/>
    <dbReference type="EnsemblBacteria" id="ACU08512">
        <property type="protein sequence ID" value="ACU08512"/>
        <property type="gene ID" value="FIC_02075"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02075"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_10"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="142"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="245" mass="28433" checksum="9C79E268133D329B" modified="2009-09-22" version="1">MRYFIEFSYHGKNYFGYQIQPREITIQQELEKALSTLLRAEIKTTGAGRTDTGVHAKKMYAHFDTEIAVEDNLPYRLNSFLPQDIAVSRIFKVKDDLHARFDATFRTYEYYISLAKNPFSQDFSWQIRNRTLEIGKMNEACRILFEYEDFTSFSKLHTDNKTNNCKIYKAFWEQNGNELKFTVSADRFLRNMVRAIVGTMVEIGNGKIQPMDLRKIIEAKDRSFAGTSAPAQGLFLVDVGYDFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X255</accession>
    <name>C6X255_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">FIC_02081</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806802.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02081"/>
    <dbReference type="PeroxiBase" id="7262">
        <property type="entry name" value="FbKat01"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08518">
        <property type="protein sequence ID" value="ACU08518"/>
        <property type="gene ID" value="FIC_02081"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02081"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_10"/>
    <dbReference type="OMA" id="VMWQMSD"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="16">
        <location>
            <begin position="33"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU08518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="711" mass="80450" checksum="C96E813B0D472804" modified="2009-09-22" version="1">MKVNEQEPFANGANPKIEQLGKYKNSDHGEFMTTDHGVKINDDQNSLLGGERGPSLLEDFIFREKMTHFDHERIPERIVHARGSGAHGYFQLYKPMGKYTKAKFLNDTTIKTPVFVRFSTVQGSRGSTDLPRDIRGFATKFYTQEGNYDLVGNNTPVFFIQDAMKFPDLVHALKPEPDNEIPQAASAHDTFWDFISLMPEAMHNIMWLMSDRAIPRTYRAMEGFGIHTFRFINEEGQSHFVKFHWKPLQGVLGLAWDEAQRLSGKDNDFHRRDLWDAIENGMYPEWELGVQIVPQEDEHKFPFDLLDATKMIPEEMVPVEIIGKMTLNKNPDNFFAETEQIAFHPGHIVPGIDFTNDPLLQGRLFSYTDTQLSRLGGPNFHEIPINRSIPDVTNNQRDGLHRMQIPKGKVSYHPNSMAQGCPFQAMMKEGGFTSFEERIDSRKIRNRSRSFFDHFSQPTLFYNSLTDHEKRHVQNAFSFELGKVKLVPIRQRMVNMLLEVDKELANKVGDHLGLVPERLPQPITDSIPADGKLEDYHSFKAELPISEAPSVSMATKLPQNIKARRIAILTADGVSDEAFTKVKKVLCEMDALVQIIAPRHGFVTTASGDQYPVDDSLLTTASVIFDAVYIPGGDSVKTLMEHAGAIHFVAEAYKHCKPFGADGNGVDLLQKAIPKLTLPADGIVTEGDLDLFTASIILHRFWDREMNPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X265</accession>
    <name>C6X265_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonine dehydrogenase-related Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806812.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02091"/>
    <dbReference type="EnsemblBacteria" id="ACU08528">
        <property type="protein sequence ID" value="ACU08528"/>
        <property type="gene ID" value="FIC_02091"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02091"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_10"/>
    <dbReference type="OMA" id="ETWYAMS"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="383" mass="41148" checksum="797237DB75E40C1D" modified="2009-09-22" version="1">MLAMNFRGPFRVRADRNMPEPQIEHPQDAIVRVLRSCICGSDLHLYHGLVPDTRVGTTFGHEFIGEVVEIGSSVEKLKVGDKVMVPFNIACGKCAFCKQELYGNCHESNPMATAVGGIFGYSHTAGGFQGGQAEYARVPYADVGPTVIPDWMDNDDAVLLTDVVPTGYQAAEMAGIQEGDTVVVFGAGPIGIMAAKSAWLFGAGRVIVIDHLEYRLDFVAKYAQCEAYNFRSIGDPVVFIKTQTDSLGADVCIDAVGCEAKGDLMNTLLGTKLLMQGGSTTALHWAINGVKKGGIVSIVGVYGPIDALVPIGNVVNKGITIRANQAAVKRNLPKLIEHVKNGVLDPKQIITHRVPLEEVADAYHIFSQKLDNCIKTVLIPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X289</accession>
    <name>C6X289_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02115"/>
    <dbReference type="EnsemblBacteria" id="ACU08552">
        <property type="protein sequence ID" value="ACU08552"/>
        <property type="gene ID" value="FIC_02115"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02115"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_4_3_10"/>
    <dbReference type="OMA" id="MESDHIL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="207" mass="24206" checksum="AF3DCD039B3FC346" modified="2009-09-22" version="1">MVNLKESKPMFVRETLLENGIPVLHLNKKDTLFREDQKAVNLFYLMEGEIKIYNTDSEGKEFLINKVNEHQFLGEPPFLLGEKYPANAEIASETAEIFSFSEELFKQYMVNHPEMLFEFTKEIAKKAYEKTLRLKSIVHQCPHERITNFLKIHKKNLGIDDGQKAIINVTRKEMANSTGLAIETVIRTVKKMEREDKLKLINHKIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X296</accession>
    <name>C6X296_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.51" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02122"/>
    <dbReference type="EnsemblBacteria" id="ACU08559">
        <property type="protein sequence ID" value="ACU08559"/>
        <property type="gene ID" value="FIC_02122"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02122"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_6_2_10"/>
    <dbReference type="OMA" id="RHAPLWP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="76"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="241" mass="27788" checksum="CF8F75835B956647" modified="2009-09-22" version="1">MKKILNYMWRGWMVLLGALLTMTLGIPVLLLSIRKEHYKYAYKFIRIWCFGMFYGMGFRYELKSLTDKKIDKNRQYVFISNHSSLMDVMLPCILMPDHPLCYVGKKELVKIPIFGTIYKRICVMVDRSSAKSRADVYRRCAERMEEGQSIVLFPEGGVPDDTSVVLDKFKDGAFIVASKHQSPLIVFTFVGLKKMFPFDHSKGHPGKVRIYLNDIIEPHASAEVMKDEAHAQIKKVLLNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C6</accession>
    <name>C6X2C6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806873.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02153"/>
    <dbReference type="EnsemblBacteria" id="ACU08589">
        <property type="protein sequence ID" value="ACU08589"/>
        <property type="gene ID" value="FIC_02153"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02153"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_0_10"/>
    <dbReference type="OMA" id="IKSPIIG"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="84"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="162" mass="17570" checksum="3740D24D2FB051BA" modified="2009-09-22" version="1">MDIKDIQNLIKFVSRAEVSEVKYKTKDFEITIKTPLGGNEVTYMQQPGVYHSAPQHAPGSAPSVPASQNAPAAAAEPAAEDSNFITIKSPMIGTFYRKPSPDKDVFVNVGDEVSAGKVVCVIEAMKLFNQIESEISGKIVKILVDDATPVEYDQPLFLVDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D9</accession>
    <name>C6X2D9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Thrombospondin type 3 repeat:OmpA/MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_02166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806886.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02166"/>
    <dbReference type="EnsemblBacteria" id="ACU08602">
        <property type="protein sequence ID" value="ACU08602"/>
        <property type="gene ID" value="FIC_02166"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02166"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043946_0_0_10"/>
    <dbReference type="OMA" id="RYMFNEK"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973496" evidence="11">
        <location>
            <begin position="21"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="12">
        <location>
            <begin position="359"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="477" mass="52048" checksum="6C9C7855A85DD71A" modified="2009-09-22" version="1">MKLTLASLALAIALPASMFAQDSIAVSTDGYPNTYSSGSANVAPFTQDSKRFNDWAISVGAGVPMLYGADLSSINNGNGKNLFGYSAYLSVDKAITHAFGLKLQYDRGETRQGWFNTKTDDASGTGYQDVGARTQYDAVSVLGDLNFSNLLRRVDNKSPYRWALHGYAGIGSIGYRAYVEDAAGQRLVTEVKPSLDKWSLFGQAGAGLKYKVNRRIDLEGRLMYVVTTDDSFDGGAGQYNAREEQVSDNFMNATLGLSLKLGKHESHLMWHDPLQEIYYKLDVLADKNQDVEVCKKGDADNDGVCDDWDRQLDTPAGARVDGAGVALDTDLDGVIDLYDKCVTVPGPVENNGCPTGTTVTDNTRTLEGIEFDFDSDRILPSNTPILNNAVNYINTSNGNYSVIGGTDASGSEAYNQGLSERRANTVKNYLIQNGVESAKLQSVGRGEKELKYPECNPTSKCPEWKNRANRRVYFEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F3</accession>
    <name>C6X2F3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806900.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02180"/>
    <dbReference type="EnsemblBacteria" id="ACU08616">
        <property type="protein sequence ID" value="ACU08616"/>
        <property type="gene ID" value="FIC_02180"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02180"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_0_1_10"/>
    <dbReference type="OMA" id="VETQYQR"/>
    <dbReference type="OrthoDB" id="1573349at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="22704" checksum="7F66E2CD3DA30770" modified="2009-09-22" version="1">MKNRGCMSAGTIGIALLVIAAILFFWGKNGYNTFTTKEQNVNTKWSNVETVYQKRANLIPNLERTVKSYSQFEQETLTNVVEARSKATSINVDPTNMTEADIAKFQAAQGELTGALSRLMAVVESYPNLKADQQYLNFQREYTAIENSIRSETVYFNEAAQDYNTSIKTFPNNILANFTNFKEKPYFKAAVGAENAPEVFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N5</accession>
    <name>C6X2N5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative arginine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806982.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02265"/>
    <dbReference type="EnsemblBacteria" id="ACU08698">
        <property type="protein sequence ID" value="ACU08698"/>
        <property type="gene ID" value="FIC_02265"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02265"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027243_2_0_10"/>
    <dbReference type="OMA" id="YCYCTKS"/>
    <dbReference type="OrthoDB" id="164471at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002985">
        <property type="entry name" value="Arg_decrbxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43295">
        <property type="entry name" value="PTHR43295"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="2">
        <location>
            <begin position="74"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="1">
        <location>
            <begin position="313"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="463" mass="54052" checksum="F479128B6AA96C1E" modified="2009-09-22" version="1">MKIKYSELIDQTLYFPTEEFNVSENTLLFHDIPLMDVVEQFGTPLKFNYLPKISMNIQRAKAWFKEAIEKNDYKKGYRYCYCTKSSQFAFVLEEALKNDISIETSSAYDMDIVKALYDKGKYDKDVEVICNGFKTDDYLAKISDLINSGFQNIVPVLDNYRELDKLTESIDTTFNIGIRIASEEEPKFEFYTSRLGIGYKDIIPYYSQKIAEHPNARLKMLHFFINTGIKDTAYYWNELYKCLRVYARLKKIAPEVDSLNIGGGFPIKTSLNFDYDYQYMVNEIVSQIKKFCEEEGVEEPNIYTEFGSFTVGESGGNLYKIISQKRQNDREKWNMIDSSFMTTLPDTWAISRHFIMLPLNRWDDTYERVFLGGLTCDSDDYYNSEQHTNAIYLPVFSDTKPLYIGFFHTGAYQETIGGYGGVHHCLMPQPKHILINKDEEGNFTYEVFREEQRPEDVLKLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S7</accession>
    <name>C6X2S7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="8">PCK</shortName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="4 8">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckA</name>
        <name evidence="9" type="ordered locus">FIC_02307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807024.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02307"/>
    <dbReference type="EnsemblBacteria" id="ACU08740">
        <property type="protein sequence ID" value="ACU08740"/>
        <property type="gene ID" value="FIC_02307"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02307"/>
    <dbReference type="eggNOG" id="COG1866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_10"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="146648at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="243"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="443"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="534" mass="59169" checksum="2FF4C52AC6C2790C" modified="2009-09-22" version="1">MKNIKIIQQLHDLGISGYEEVIYNPSYEKLFQAEISKDNKGYEQGIVTESGAVAVKTGIFTGRSPKDRFIVKDDVTRDTIFWDGKVNLPTTAETFASCKELVLKQLSTSKKLYVVDAFCGTNPDTRLKVRFIMEVAWQAHFVTNMFIRPSNFELETFGDPDFIVMNGSKTTNPNWKEQGLNSENFVMFNLTEKIQIIGGTWYGGEMKKGMFAMMNYFLPLKGMASMHCSANVGKDGDVALFFGLSGTGKTTLSADPKRYLIGDDEHGWDDNGVFNFEGGCYAKVIDLTEEKEPDIYKAIRRDSLLENVVVNDAGEADYTDNSITENTRVSYPIYHISKIVLPSKAGHAKKIVYLSADAFGVLPPVSVLNEDQAQYHFLCGYTSKLAGTERGITAPEPSFSPAFGEAFLTLHPTMYSKTLIGKMKEHGAKAYLVNTGWNGTGQRISLKDTRAIIDAIIDGSIDTAEKSTIPIMNLEIPTALPNVSAGILDPRDTYASASEWEEKAKDLAARYIKNFEQYCNNDAARKLVAAGPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U2</accession>
    <name>C6X2U2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_02322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807039.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02322"/>
    <dbReference type="EnsemblBacteria" id="ACU08755">
        <property type="protein sequence ID" value="ACU08755"/>
        <property type="gene ID" value="FIC_02322"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02322"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_10"/>
    <dbReference type="OMA" id="CECLNLP"/>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="315"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="436" mass="48261" checksum="36A0F56AD02899A6" modified="2009-09-22" version="1">MNITIVGTGYVGLVTGTTLAELGNTVFCVDIDEEKVAAMKQGRVPIYEPGLEEMFLRNIQAQRLFFTTSLEEALEKSEVIYLALPTPPGEDGSADLSYVLSVAHKIGDLLTDYKVIVNKSTVPVGTADIVREAISAKTDVEFDVVSNPEFLREGFAVEDSMNPARVIVGSESERAKEIMSKIYQPFTNTGVPIIFMDERSSELTKYAANSFLAVKITFMNEIANYCEKVGADVDKVRLGMGSDDRIGHRFLFPGIGYGGSCFPKDVKALIKSGKQENFDFQLLEATENVNQAQKVILVSEIEKYFGGNLQGKKIAVWGLAFKANTDDIREASALDNIRLLRAKGAEISAYDSIAEENVRRILGNDITYANDMYSALQDADCLLIATEWSEFKNPNFELMAAKMKNKAIFDGRNMFALEQVENSGFYYKSIGRKTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V7</accession>
    <name>C6X2V7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02337"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08770">
        <property type="protein sequence ID" value="ACU08770"/>
        <property type="gene ID" value="FIC_02337"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02337"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_10"/>
    <dbReference type="OMA" id="INMNIGG"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="232"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="419" mass="48360" checksum="94D0F04969E3C207" modified="2009-09-22" version="1">MKSLLQNSENGSTISKYNTENWAPMSTEKIKLLFRHRSMEMGGVEKVLLSLLNNLDHNKFEMTVLLSLDQGELRDDFPAHVRKVVLAKGKESFDKNKLVNKAQLVARRLKLEFLRKFPQLIDRHYLKEYFDIEIAMTYNDFELVLNSSNKKSKKIGWFHSEIDHPKLHVVVPRILAQFPRFDHMVYCSEKIRDLMHHVYPDIAYPAESVIINAIPIEEIKEKAGETISDLPKSPVFTSVGRLHSRKGHHMLMDVHAELLNDGYEHSVVVIGDGEELPNLLAQQKKLKVEKTFLILGNKMNPYPYIKNADFFIMPSESEAWPLVIAEALILQKPIIATEVGDVGLMIANKKTGYLINYKKEEMYAAMKEFLTNPVLLEDINYELKNIENQFDNKKIFSDVEEIILDLAHDHKKMEDSINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W9</accession>
    <name>C6X2W9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02349"/>
    <dbReference type="EnsemblBacteria" id="ACU08782">
        <property type="protein sequence ID" value="ACU08782"/>
        <property type="gene ID" value="FIC_02349"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02349"/>
    <dbReference type="eggNOG" id="ENOG5033XMY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2395386_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="93" mass="10116" checksum="3C4E8C86BBAC249F" modified="2009-09-22" version="1">MEGRIISTSVDYRKFRLKIVSSNAVMAQTALQSGGEFKLSGPISDDSFAVTATEKIKSFNADKPGLTISADAMQINVPKGITYVKFNEIVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X309</accession>
    <name>C6X309_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methylase, SpoU family</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02389"/>
    <dbReference type="EnsemblBacteria" id="ACU08822">
        <property type="protein sequence ID" value="ACU08822"/>
        <property type="gene ID" value="FIC_02389"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02389"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_4_3_10"/>
    <dbReference type="OMA" id="PQFGTKH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="197" mass="22075" checksum="C0ED741937BB2108" modified="2009-09-22" version="1">MRLIRRQAFILVNFAKNTKMSSTKKLKLEELGRIDVETFKQTQKTGLTVVLDNVRSMHNVGAIFRTADAFLIEKVVLCGITPQPPHREIHKAALGATESVEWIYVDTVSAALETLKKENYTVIGIEQTSNSQKIGDYHISKDQKYAVVLGNEVDGLSEDALALYDAFLEIPQLGTKHSLNVSVCGGIVMWEFFKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X323</accession>
    <name>C6X323_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug resistance protein, AcrA/AcrE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807120.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02403"/>
    <dbReference type="EnsemblBacteria" id="ACU08836">
        <property type="protein sequence ID" value="ACU08836"/>
        <property type="gene ID" value="FIC_02403"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02403"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_10"/>
    <dbReference type="OMA" id="ARINLNW"/>
    <dbReference type="OrthoDB" id="1579676at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="55"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="409" mass="43655" checksum="6053AAF19120D6DF" modified="2009-09-22" version="1">MKNSLIILSLSLLGVLSCSKKEEAKQEGPKEVPVIQVQVRNVTGYKSFPASIQGRTNNDVRAKIQGYITQVLVDEGQYVTKGQPLFRLETNMLNQSAGAARAGVGAARSGVSAAKANVSAAQAEVNASQVEVNKLIPLVQKNIISNVQLETAKANLARAQAQLAQARAAEQQASAGVSQASATYQGVQANIDYSVIRAPISGVIGRLPLKVGSLVGPQDPTPLTTVSDTSAVFAYFSMNEREYFDFLENSYGATVPEKLKNLPMVELILANGSTYSEKGKIEAATGQIDTQTGTIQFRVSFTNAAKLLTNGNSGTIRVPKLYDQALVVPESSTFEQQGLVYVYRVEKDTAKNILIGVTDRVNNMVVVKDGIKKGDPIVAQGVGTLKPGTAVKPKPVDFDEIVNAIKPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X352</accession>
    <name>C6X352_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ordered locus">FIC_02432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807149.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02432"/>
    <dbReference type="EnsemblBacteria" id="ACU08865">
        <property type="protein sequence ID" value="ACU08865"/>
        <property type="gene ID" value="FIC_02432"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02432"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_2_2_10"/>
    <dbReference type="OMA" id="VVHVFQK"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="13986" checksum="AE5EB2B2D5E4C48D" modified="2009-09-22" version="1">MNRIIDKQQLTDKIVEAIQDTKGEDIMIFDLSKIENSVAQTFIICTGNSNTQVSAISGNVEKKVRNDLQDRPWHVEGTENSLWVLLDYVSVVVHIFQRETREYYDIEELWGDALITKIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X375</accession>
    <name>C6X375_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02455"/>
    <dbReference type="EnsemblBacteria" id="ACU08888">
        <property type="protein sequence ID" value="ACU08888"/>
        <property type="gene ID" value="FIC_02455"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02455"/>
    <dbReference type="eggNOG" id="ENOG50333UQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180673_0_0_10"/>
    <dbReference type="OMA" id="IMIKEKI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="100" mass="11984" checksum="5C1FC0AF51B7C8AD" modified="2009-09-22" version="1">MHFGTVVIRIFTVKLSIMIKEKIRKEVTLDKQIVEKLKIQAMEDGRNLKNYLEKILTDKATEEFEITEGYIKMMDELMDKRAKGELNFTPWEEVKKKYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D5</accession>
    <name>C6X3D5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807232.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02518"/>
    <dbReference type="EnsemblBacteria" id="ACU08948">
        <property type="protein sequence ID" value="ACU08948"/>
        <property type="gene ID" value="FIC_02518"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02518"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602369_0_0_10"/>
    <dbReference type="OMA" id="IWFTTSA"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970612" evidence="1">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="386"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="454" mass="47880" checksum="E324B8ECC7C4202B" modified="2009-09-22" version="1">MKKLLLTGFALVSMASQAQSWVPQATNFPLNSGVDEIDIVDANVVWTFAYGPTATSYPKIVGRTINGGATWTATTLTNIGNNALISDLTAVDANTAWVLTAGTGQAGANPNRIWKTTNGGTSWTQQAVAYNTPSFANQIHFWNANEGWTAGDPLPDGFFEMYKTTNGGTTWTLVPGRPASEGDYSYVGLKEVVGDIIWIGTDTGRILKSLDRGNTWMAGYSPVLDFGGATQAGSSGSFAFQDADNGLLIAVDGAALPSTTTASLYKSTDGGMTWGDPISPTGPWYFGDITYVPGTVSTYVSTGANPGTLAEPRPQWMGSSYSTDGGLTWIEIDSGEQRGKVAFLNPTTGWAGQFSDGPTATEGIMKFVGNLALGTSDNAVKSSLKVYPNPAVDVVTVSSNKKIENITVIDMSGKKVQSFKAGNQINVSSLAKGTYMLQVYYGGGAVENTKLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D7</accession>
    <name>C6X3D7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807234.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02520"/>
    <dbReference type="EnsemblBacteria" id="ACU08950">
        <property type="protein sequence ID" value="ACU08950"/>
        <property type="gene ID" value="FIC_02520"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02520"/>
    <dbReference type="eggNOG" id="COG3091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275789_0_0_10"/>
    <dbReference type="OMA" id="KYRFLIT"/>
    <dbReference type="OrthoDB" id="1294292at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="196" mass="23250" checksum="63EF8EF02CBBFE1B" modified="2009-09-22" version="1">MSISNLEKYLPENTLPYLKKWFGSHSIHIRITRGRNSKLGDYRRMPDQSHKITINSTLQPQLFFFVLTHELAHLIAFADFGHRISAHGQEWKQTFREMLLESLPVYEDDLKPVILNYAKSPKANFMSSPELVKYFHIENYEDESSYIEDLEPGALFVYRKERYRLEEKRKKNYLCTNLGSAKKYVFRPLARVEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D9</accession>
    <name>C6X3D9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02522"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08952">
        <property type="protein sequence ID" value="ACU08952"/>
        <property type="gene ID" value="FIC_02522"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02522"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_3_0_10"/>
    <dbReference type="OMA" id="THPYAGF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="323" mass="36571" checksum="605CE8F984591E0D" modified="2009-09-22" version="1">MKTILAYRFSAFGDVAMTVPVFTEFIQQNPDVHIVFLSRENFRDLFEGIPNFTFKGINIDEYKGFFGMRKLAKELKSEFKPDCIADLHDVIRTKILSRAFRRKGHAVHVIDKGKDDKEQLTNIWNIEKQPLKHNTERYADVFREMGFSVELSHRFRTVSGVKSGIGIAPFAQHAGKMLPLDKSFELAKILSAKTKIYFFGGGAAEVEKLNEWTAQIPNSENLAGKLSLKQELHKIASLEAMISMDSANMHLASLVGTRCVSVWGSTHPFAGFLGYGQIEEDTVQIKDLTCRPCSVFGDRPCYRGDWACLHEIDIQQIISKIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E3</accession>
    <name>C6X3E3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent Clp protease, ATP-binding subunit ClpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_02526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807240.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02526"/>
    <dbReference type="EnsemblBacteria" id="ACU08956">
        <property type="protein sequence ID" value="ACU08956"/>
        <property type="gene ID" value="FIC_02526"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02526"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_10"/>
    <dbReference type="OMA" id="GPEHILM"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="839" mass="94518" checksum="1962F0CF4C066AAE" modified="2009-09-22" version="1">MDHKFSNGLDQVFQQSKSEAKRLQSEFLNTEHFLLGMIKTENSAKEILQSLGADLTQIRRKIENMSAAGLNPFAADSGKISFTKMADQAVKRSELECRQYQGSEINTVHLLLGMLYKSDDPTTSILSSYDIDYERVTSEYRSMLKNSGQGPKMSAYDDDEEREEFGQMRKPTGNIGAGKSKTPTLDNFGRDLTTLAKDGKLDPVIGREKEIERVSQILSRRKKNNPLLIGEPGVGKSAIAEGLALRIQQKKVSRVLYGKRVITLDLAGLVAGTKYRGQFEERMKAIMTELEKNRDVILFIDELHTIVGAGSSTGSLDASNMFKPALARGEIQCIGATTLDEYRQYIEKDGALERRFQKVMVEPTSVEETVQILNQIKDKYEDHHNVVYSDEAIQACVNLTARYITDRFLPDKAIDAMDEAGSRVYIKNMKVPTEIIEHEKQIEDIKEQKQKAVKRQDYLEARKLKDEEERLQIELNLAQETWDKNVKEKKEEVTEESVAEVVSMMSGIPVTKVGKNELDKLSHMDEMMNGKVIGQEDAVRKVVKAIQRNRAGLKDPNRPIGTFIFLGTTGVGKTELAKVMARELFDSDEALIRIDMSEYMEKFAVSRLVGAPPGYVGYEEGGQLTEAIRRKPYAVVLLDEIEKAHPDVFNILLQILDEGFVTDSLGRKIDFRNTIIILTSNIGTRDLKDFGDGVGFGTTAKKSNSDARARSTIENALKKAFAPEFLNRIDDIVIFNNLEKDHISKIIDLELEKLYKRLEKLNYKVDLTQEAKDFIAEKGWDKDFGARPLKRAIQKYIEDLLAEMLVNKQLAEGGTLLLNVNEAKDGLVGEPVKKKQSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H2</accession>
    <name>C6X3H2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02555"/>
    <dbReference type="EnsemblBacteria" id="ACU08985">
        <property type="protein sequence ID" value="ACU08985"/>
        <property type="gene ID" value="FIC_02555"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02555"/>
    <dbReference type="eggNOG" id="ENOG502Z8AQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053286_0_0_10"/>
    <dbReference type="OMA" id="WAFIIPI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045726">
        <property type="entry name" value="DUF6080"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19558">
        <property type="entry name" value="DUF6080"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="438" mass="51434" checksum="3132D45D5326D60B" modified="2009-09-22" version="1">MQFVIFITFAEISTLVIKKKLAGFVQTVFPATRAELLLFAIFLSVYGTFGTYIALNYRIIFDDRIPWDAYFSFDNRAIVLTGGGYERHPLANYFFGWLREFAYLFSDGKKNDVFRLVLAWCSNITISLSLIQVYKYLKNIIGLPNKISVLLLFFFACFSTNILLSFTPETYTYTLFFLILFNYYAALKLKKDQKIFAVPLTLAAISVGGLTITNIVKVYIPLLFEKDILWNWRKIGNTMLRILASAAVFLLLFLYRVDFKFLSFLNKSGEQFEKFSKPKVIPVWDMVSSWFLGGNILLAGFEIRDYHNRKGFEYKALFMEVYNSWVPYLFVLAVVLLIFWSYVKNFKRRFVQILMLSFLVDIAIHVIFRFGLHTSYIYGGHFVFVFPLMLGWLFYAYRNAAKTLSVLYYSVLVLFFYLLLNNIFRISEFFTFLEAYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J4</accession>
    <name>C6X3J4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807291.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02577"/>
    <dbReference type="EnsemblBacteria" id="ACU09007">
        <property type="protein sequence ID" value="ACU09007"/>
        <property type="gene ID" value="FIC_02577"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02577"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372082_0_0_10"/>
    <dbReference type="OMA" id="MVKAFAY"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="687"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="757"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU09007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="813" mass="91946" checksum="0457F2D8C932DFF5" modified="2009-09-22" version="1">MNYTTLQLSEITGSELIGDGKLCVTGMAYDSRNIFSPLNTAFLAINTAKNSGEKYITSAIEKGISVVISQHRIESETDVTWIIVEDSLKFIQKLAKYHFAQFTLKTTIGITGSNGKTIVKEWLYQSLFDEFITVKSPKSFNSQLGLPLSLLKVSARDEIGIFEVGISKPSEMERLADIFKPQIGVLTHIGPAHESNFENQKQLIEEKIKLFSDSDVILFNGDNLLVHSLITERYSSKKLISYGFETHNDIFIKSSPKEGDLSIVYFGEEFNLPAQRRDEATLNNALCVIAVLKVLGFSTDIIREKINMLKPVEMRLESVKGLRNNLIINDYYNLDLDSLKIAFQFINEYNKPAKTLVLTDFVEGKETTLLYQTVSNLTNQQKFQHVFLIGDEITKYSELFEGDVAVFNNTTQLIESHYLDSVENELILLKGARKFEIEKVKDHLELQKHDTVLEVNLNAVLHNINVHKSLLKPKTKMMAMVKAYSYGLGGYEIAEFLQHHHIDYLGVAYADEGADLRKNGISVPIMVMNPEQHSYDSIIEHHLEPEIYSFRVLDLFNQQLIRKGADKDYPIHIKLETGMNRLGFREDEIDELAARLAKMDVKVASVFSHLSTADSEEEHNYTMHQIEKFQSISTRLAEKLKYEPIRHILNSSGIANYADYQFEMVRIGIGMVGITSNEQIKNQLRNVVSFKSVISQISEINAGDSVGYDRKYKATKRTRIATIPVGYADGVPRMIGNGIGHVSISGNLYPIVGNICMDMMMVEVGDSSAKEGDEVIIFNSKPSLAEFSDYCKTIPYEVLTSISRRVKRVYIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J8</accession>
    <name>C6X3J8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02581"/>
    <dbReference type="EnsemblBacteria" id="ACU09011">
        <property type="protein sequence ID" value="ACU09011"/>
        <property type="gene ID" value="FIC_02581"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02581"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068669_1_0_10"/>
    <dbReference type="OMA" id="DYISHTD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU09011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="273" mass="31540" checksum="C36F326DC6DFB845" modified="2009-09-22" version="1">MMKITDHFLSKETFELVETEVPGVLKTSPIPSDLGRYYESKDYISHHQDSGSLKEKIYKKLQKVNLNFKRNILAKELPKDANVLDYGCGAGEFLKYIETDFTTFGYEPSATARQLSIQKFTKTKVINDLSVIADQSLDAITLWHVLEHIDNQDDILNLFHNKLKPNGLLIIAVPNHTSYDAKRYKEFWAAYDVPRHIYHFSKNGMGILMNNEKWNLKYTRPLLLDSFYISMLSEKYKKSPIFWLKGFIFGAISNFKAVKTGEFSSLIYVIGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L4</accession>
    <name>C6X3L4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782149.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00544"/>
    <dbReference type="EnsemblBacteria" id="ACU07002">
        <property type="protein sequence ID" value="ACU07002"/>
        <property type="gene ID" value="FIC_00544"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00544"/>
    <dbReference type="eggNOG" id="ENOG502Z9ND">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045371_0_0_10"/>
    <dbReference type="OMA" id="TPGGWDK"/>
    <dbReference type="OrthoDB" id="1184718at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025970">
        <property type="entry name" value="SusE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14292">
        <property type="entry name" value="SusE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970621" evidence="1">
        <location>
            <begin position="26"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="SusE" evidence="2">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="SusE" evidence="2">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="476" mass="50970" checksum="95C675E7000A05DF" modified="2009-09-22" version="1">MKNIFKVLMVFLLPLLLVTSCRTDADRDWTSPEGSFTLHDTALGATVLYPSMESNPYILTWDAPAGATSYSVVVSSTEDFAAKAVVGTSDKTTLRTTIGELNMAMLQAGINPYSPQTVYLRVESGSAVSNTISFTVTPYPVAVPVITKPTAGQTIVLDAANPLATAATVTWTDYTYGVNVSYNVEIAKKGSTDFVSTGTVTDAKELVWTNFALNNAVLSAGLPVGVSSEVDVRVTASTTSVGGVITKTSDIVTFKVTPFQPAFVDFYLVGGGTAVGWNGTGAQKLYRTEEISEIYTYLESNGEFRFLGQQDWSPINYSLNADGINDSYKYFNTWSANLEPAGSENMKFTGNSGLYKITIDQNSRSITVTPSSVPTLPAQVYLVGSIQGWDAGNAIAMTQTGDGVFEHIIAIPDGSEFKFLGQQDWSGVEWGNIHTGGNSGYLGPNGDNNNIQFSGGNNMYKVTVNVKLGTYTLTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L6</accession>
    <name>C6X3L6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase (Neopullulanase) SusA</fullName>
            <ecNumber evidence="3">3.2.1.135</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.135" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00546"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07004">
        <property type="protein sequence ID" value="ACU07004"/>
        <property type="gene ID" value="FIC_00546"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00546"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_3_10"/>
    <dbReference type="OMA" id="IVGEEWS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031216">
        <property type="term" value="F:neopullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015171">
        <property type="entry name" value="Cyc-maltodext_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019492">
        <property type="entry name" value="Cyclo-malto-dextrinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10438">
        <property type="entry name" value="Cyc-maltodext_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09087">
        <property type="entry name" value="Cyc-maltodext_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="151"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="646" mass="74819" checksum="984728446373F44D" modified="2009-09-22" version="1">MALASLAPPKLTLSRFKTLTRFFLKIIIMKRLSLFFLFISVFGFAQIQKVEPAFWWKGMKNPELQILVYGKNISKYSVELSDNIQVKDLTKTENPNYVFITVNTDEISTSAFKINFKEKNRTRYSYTYELRNRKPGSAERNSFTSKDVMYLIMPDRFANGDPSNDSQPDLTDKLNRNAPNGRHGGDLRGIINNLDYLQNLGVTALWLTPANEDNEKQTSYHGYAQTDLYKIDGRYGTNEEYLELSRELQKRGMMLIQDYVTNHWGISHWLIQDLPTQDWIHQFPDGDGKYGFKRSNYRITSQFDKNAAKTDKDEALNGWFDTTMPDLNQQNPLVLKYLTQNAIWWIEYAELGGLRVDTYPYNDKEGMAKWAKAITNEYPKFNIVGEAWMSSPAQVSYWQKDSKIAEIDHYNSNLPSVMDFPLYTDLPSAFKEEESWDKGMIKLYNSFGNDFLYPDIDNILVFFENHDTERLNEMFNADPRYYKMAMTLISTVRGIPQIYYGSEIGMRGEKSKGDADIRRDFPGGWKGDAQNAFNPQTQTAEQKEFFDFTQKLLNWRKGKTVIHTGKTTHYMPKDGVYVYFRHNDNEKVMVVINKNEKDQSFDLKRFAQSLNGVTAGTDIISGKQFQVSTENKLTVSAKSSLILELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P0</accession>
    <name>C6X3P0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ordered locus">FIC_00570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00570"/>
    <dbReference type="EnsemblBacteria" id="ACU07028">
        <property type="protein sequence ID" value="ACU07028"/>
        <property type="gene ID" value="FIC_00570"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00570"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_4_0_10"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="100"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="301"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="101"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="427" mass="47035" checksum="FA13DEFFA7ABBF28" modified="2009-09-22" version="1">MTNMNAATFYPLFLQSANATIDSRTLKKDDIFFAFSGDSFNAATLAEDAADKGALAVIVEQKAYENPARDIFYVPSTLNFLQELATHHRDQLDIPVIALTGSNGKTTTKEIIHAVLAQKYNVQYTSGNLNNHIGVPLTLLSVRSHHNMAVIEMGANHQKEIEMLCEIAKPTYGYITNFGKAHLEGFGGFEGVIKGKSEMYSYLRANSQTILVNENDAIQVENTAGYSPVITFGKPDSDYLFEEVSNQNFVGLRFGDQTAHSQLTGSYNFTNLCAAASLGLHFGISFREIKTAIENYVPTNMRSQILEKNGKTLVLDTYNANPSSMEESLKNFNRFEGSKTIIIGDMLELGNESEAEHRRILDLAGSLAFDAVVTVGENFRRINPGSQSYKSAQELADALKLNPINSQNILLKGSRGIALEKILDFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P1</accession>
    <name>C6X3P1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782176.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07029">
        <property type="protein sequence ID" value="ACU07029"/>
        <property type="gene ID" value="FIC_00571"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00571"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104636_0_0_10"/>
    <dbReference type="OMA" id="MYKVFVN"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="201" mass="23572" checksum="4DFB22F541A59A7F" modified="2009-09-22" version="1">MYKVFVNEKKLTLSKYPEDIEKKLRFEGFATLEIAVDLLQNTSCPEINVYGENIEEMWEDFTHMFKVIEAAGGVVTNQKDEILFIRRLGKWDLPKGKIEKGESLEQAALREIEEETGLKELILEEFLNNTFHLYTERNGDKILKTTYWFRAKYVGSETPVPQQEEGISEVSWKNEEAITNEVLPETFKNIKLILNEYWTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y6</accession>
    <name>C6X3Y6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate lyase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Isocitrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Isocitratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782270.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00669"/>
    <dbReference type="EnsemblBacteria" id="ACU07124">
        <property type="protein sequence ID" value="ACU07124"/>
        <property type="gene ID" value="FIC_00669"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00669"/>
    <dbReference type="eggNOG" id="COG2224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_0_10"/>
    <dbReference type="OMA" id="LEKDWAE"/>
    <dbReference type="OrthoDB" id="152545at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="312"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="428" mass="47196" checksum="2167A8912F08FAB0" modified="2009-09-22" version="1">MKNQEQIRQIEKDWLENPRWTGVQRPYSAEEVLKLRGSYQLDYTIAKLMSEKLWEKLNSQDFVAGLGALTGNQAVQEVDAGLEAIYLSGWQVAADANLSGEMYPDQSLYPANSVPSVVKRINNALLRADQIQSVNGIDDSDRKEYLVPIVADAEAGFGGNLNAYELMKQMIEAGAAGVHFEDQLSSAKKCGHLGGKVLVPTQEAINKLIAARLAADVCGVPTLVVARTDADAADLLTSDIDTRDHKFVTGKRTTEGFFEVKNGVEQGIDRGLAYAPYADLIWMETSNPDLDYARKFAEGIHAKFPGKMLAYNCSPSFNWAAKLSVEEMATFREDLAAMGYKFQFITLAGFHALNTSMFELALAYKKRGMAGYSELQEREFALQKEGFRAVKHQNFVGTSYFDALQTVITSGDSSVVAMKDSTEAAQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X472</accession>
    <name>C6X472_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00755"/>
    <dbReference type="EnsemblBacteria" id="ACU07210">
        <property type="protein sequence ID" value="ACU07210"/>
        <property type="gene ID" value="FIC_00755"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00755"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079350_1_0_10"/>
    <dbReference type="OMA" id="QKQTYRN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014985">
        <property type="entry name" value="WbqC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08889">
        <property type="entry name" value="WbqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="233" mass="27196" checksum="6E156B02142629AA" modified="2009-09-22" version="1">MLRCASQKDAATIGARGNRCKLKHFIIQKRKMKVLLPVFYLPPISWFAVFLLADDVVLEQSENFPKQTYRNRATIYGANGRLSLIVPIHHNGKRRMSEIEVSKREKWQKLHWKSIKTAYQSSPYFEFYENKLAEIFTFETDSLLEFSLNAVAILQKILKTDIDYSLTNEYESTPTEEDFRGRFSAKQQAEFEMPEYYQTFSDKFGFEADLSVIDLICNKGPESLTYLNNIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X486</accession>
    <name>C6X486_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">fn3_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00771"/>
    <dbReference type="EnsemblBacteria" id="ACU07224">
        <property type="protein sequence ID" value="ACU07224"/>
        <property type="gene ID" value="FIC_00771"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00771"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087886_0_0_10"/>
    <dbReference type="OMA" id="NSMLFFT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="Fn3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="fn3_5" evidence="1">
        <location>
            <begin position="49"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="276" mass="30205" checksum="1AD2DF3F6FA2AEEB" modified="2009-09-22" version="1">MAIIYFNKIIMRKFIHLFTFFLILTGTSSLLAQSISMSPTRLFFTGNPGEKVTQTVTLQNSSDKDYVFNLNYKDWVREEDGNKVYLDAGSSKISNAAWVSTLENSVTVPAGAKKEITVTMQIPANAPKSVTNSMLFFTQLPQQADQARVQNGIGIITLFEVGLHIFYTPPGNSVKSLDITNIAEVSTDNSAGRKVAVSIQNDGNTINDATVEFELTDTDTGKEIKLPAISISMLPNTNQVVKFSLPENISGNFLGVAIIKMAGSNDLRVGEKNFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A7</accession>
    <name>C6X4A7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782391.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00792"/>
    <dbReference type="EnsemblBacteria" id="ACU07245">
        <property type="protein sequence ID" value="ACU07245"/>
        <property type="gene ID" value="FIC_00792"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00792"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085936_1_0_10"/>
    <dbReference type="OMA" id="WEIYRGD"/>
    <dbReference type="OrthoDB" id="1866464at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032580">
        <property type="entry name" value="SatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16264">
        <property type="entry name" value="SatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="201" mass="22891" checksum="FDBAF545908D9360" modified="2009-09-22" version="1">MIAIITGDIINSQDTDSEVWLPKLRDLLGSWSASPENWDVYRGDEFQVKCSVDQVFQKSLMIKSLIKKTENLDVRLAIGIGNEVFLSEKITESNGSAYVNSGRLLNDIKTDGRTLAIRTENENVNRDLNILFRWASIDFDSWTVATAEIIHRLLTNAELTQDQLAKDLNISQSSVSQRLKRANYDLIHDTNLFFRKKIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C6</accession>
    <name>C6X4C6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gliding motility protein GldG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782410.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00811"/>
    <dbReference type="EnsemblBacteria" id="ACU07264">
        <property type="protein sequence ID" value="ACU07264"/>
        <property type="gene ID" value="FIC_00811"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00811"/>
    <dbReference type="eggNOG" id="COG3225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018716_1_0_10"/>
    <dbReference type="OMA" id="DQYIMNG"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019863">
        <property type="entry name" value="Motility-assoc_ABC-rel_GldG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03521">
        <property type="entry name" value="GldG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="26"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="551" mass="62734" checksum="F91913760E2D7892" modified="2009-09-22" version="1">MKRKNIIYLIAGLLLLLGVFGVFSHRFDFTQEKRYTLSESTVKILESVDQPLSVDVYLEGDFPASFRQLQNETRFILQEFRKINPKIDFKFIDPIKTKMSKDTLAAMGMQPSILPDMKDGRISEIVMFPFATLTYNTYGTAVPLIINQSGIDASEQLARSIENLEYNFASNIKAITEDQKKNVGILINQDELGPEQFQGFMDMALESYNAGPVIPENQVELSLADVPKLKQMDALVIAKPRKAFTENEKVILDQYIMNGGKTLWMIDAVNAEMDTLFRSKQIMAYPMETNLTDFFFNYGLRINPGLVKDMKKSALIRIVSGEVAGNPQFSSFLWPYFPLGIAETTNPITKNINPVKFEFPTSIDTLGRKNIRTKVLFESSDRTNVKQVPNYVALNEIVLSDSLSEFDRPTSPKIFAVSLQGKFTSAYTTRSERNAFPNFKQSSGENKMIVIADGDVGRNQVYKGNPLPLGEDLLTKQLYGNEQFLRNALDFLLDDSNLMELRNRNIEARLLDRQRIDAERTSWQWINLLLPLAIIGSLGALFFWLRKRKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C9</accession>
    <name>C6X4C9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00814"/>
    <dbReference type="EnsemblBacteria" id="ACU07267">
        <property type="protein sequence ID" value="ACU07267"/>
        <property type="gene ID" value="FIC_00814"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00814"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376811_0_0_10"/>
    <dbReference type="OMA" id="HTHACAW"/>
    <dbReference type="OrthoDB" id="314753at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="SSF49854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="1">
        <location>
            <begin position="232"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="739" mass="79347" checksum="290A79BDF11CF7DD" modified="2009-09-22" version="1">MKKIYFFCISIIYIVSIMKRIFQLCFTLAFFSLGFSQELRPIAEKVKQSQSANKTFVKYSLFTVDKSAQTQAKYQAAAEGITVMQLSKTEIQRISAERPEALEMSFPFEGKDITVQLVKNNFLTHDFKVSTDKGAVNYAPGAYYHGIVKGDNESLVAISFFKDDVMGVTSIKNVGNIIIGKAKNSDDFVSYNDVKLKGDNPFTCAADELIENQKMAAPSYDPQTMTAKKTDNCVRIYYEAGFGPYSLNGSSVPNTTNWVTGMHNNVSTLYANDGITVALSEIMVWTTTDPYSGTPSAILNQFRNTRTTFNGDIAQLLRNPATTSIAWVNALCTTYKYSYSGVTLSYQQVPTYSWNIEAMTHEIGHNLGSPHTHACAWNGNDTAIDGCGPASGNAEGCDAPLPTNGGTIMSYCHLVPSVGINFALGFGPQPGALIRNTVNSKGCLGTDCVTSCALTISGMNITNVTGTSATATIVDATGTSWKYRLSKMDGTVVTSGVTTNKVLNFSGLEEGTYYTIAVGTECSGPQAYAYEQLLLTDADWCAGVPFTDPGGANSNYGNVQIITKTFYPTASCGGTDPKLKLVFTEFSTEQGFDFMNVYNGPSTGSPRFAGGTQISGSTIPGPFTSTHATGAITVRFISDAGETASGWLAHFEQAVLGTSDTALNSAVNVAQTATKGIFAIMSKDKVLSYSVFDASGKLIIKSGKLNSGDQQVNLSAQPRGTYVVSVTTDKETITKKVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4G1</accession>
    <name>C6X4G1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="11" type="ordered locus">FIC_00846</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8 10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782445.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00846"/>
    <dbReference type="EnsemblBacteria" id="ACU07299">
        <property type="protein sequence ID" value="ACU07299"/>
        <property type="gene ID" value="FIC_00846"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00846"/>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_2_10"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="OrthoDB" id="794219at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="235" mass="25436" checksum="35903D518C78FFDA" modified="2009-09-22" version="1">MKIIPAIDIIDGKCVRLSEGDYGTQKIYGDPLEMARAFEESGIQYLHLVDLDGAKAGKVINLKTIAAVCQTGLIVDFGGGLKSRYDLELVLNAGVSKITLGSIAVENPALCREWISEFGAEKFILGADCLNRKIKTSGWLQDSDLYVIELIRSFEDTGIREVICTDISKDGMLAGPSVELYADILENTQIGLIASGGISSVEDLLNLKEIGCSGAIIGKAIYENRISLNDLKEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I0</accession>
    <name>C6X4I0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-independent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782464.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00865"/>
    <dbReference type="EnsemblBacteria" id="ACU07318">
        <property type="protein sequence ID" value="ACU07318"/>
        <property type="gene ID" value="FIC_00865"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00865"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_10"/>
    <dbReference type="OMA" id="FTHRNGR"/>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="216"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="435" mass="49326" checksum="F7049FC1732231F3" modified="2009-09-22" version="1">MELDSLYARLQIQDMNQMQKSTYAAAENGKDIILLSPTGSGKTLAFLFPVLRNLKRNVTGIQAMILVPARELALQIEQVFKSMGTDFKVSVCYGGHDKKIEINNLTQAPALIIGTPGRIAYHLQHNNFDPSSITTLVLDEFDKSLEFGFQEDMDFIIGSMEQLSQRILTSATAMQEIPKFTGLKDYKEINFLKVHESKPDVQLRKVISTSEEKLDTLFRLICKIGNKRTLIFCNHRDAVDRISELLREKGIDRETFHGGMEQDERERALLKFRNDSARILITTDLASRGLDIPEVESIVHYQLPPKEDAFIHRNGRTARMNAKGYSYLIMTEDENFPFIKNNTPEENVSENNRIPGKTPFQTVYISAGKKDKVNKVDIVGYLIKKGEISKEDIGLIEVKDTTSYVAVDRKKVVGLLKKLATEKLKGKKVKMEVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M4</accession>
    <name>C6X4M4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00910"/>
    <dbReference type="EnsemblBacteria" id="ACU07362">
        <property type="protein sequence ID" value="ACU07362"/>
        <property type="gene ID" value="FIC_00910"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00910"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896433_0_0_10"/>
    <dbReference type="OMA" id="ANGEYRM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GEVED" evidence="2">
        <location>
            <begin position="147"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="310" mass="33468" checksum="DEE33F7CABFE70AE" modified="2009-09-22" version="1">MIKVSAGVTYEFSADAIEGLPAFITISSADAATVLAAGTATVTWTADADRNVRFYTHRGANCSSNDFEFTARRVKCTQLVRDSYCEPTLDCTDGAVINRVKFAGMENISTCSNNGFADYSSKVATVQRGGTYDLEVEIGYGWFEQSVSVWIDYNKNFLFDANEFIFVGSTPQGILNKNITIPGTVANGEYRMRVRLATVGASGATAGKACDISDSYGETEDYTLKVDGTMSVGNTAAQELNIYPNPAHDFVNISGSAGIQQVLITDLSGKQVSSFAGKDKIDVSRLKAGVYMLTIRLQDGNNITRKLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N5</accession>
    <name>C6X4N5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">META domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07373">
        <property type="protein sequence ID" value="ACU07373"/>
        <property type="gene ID" value="FIC_00922"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00922"/>
    <dbReference type="eggNOG" id="COG3187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075808_7_0_10"/>
    <dbReference type="OMA" id="KGGCNRY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973585" description="META domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="138" mass="14708" checksum="CC34F2F36D9ADEB0" modified="2009-09-22" version="1">MSKEKTMKNIFIAAFAAAAMFSCSSLSTSRVGSSQASIANTKWTLADDVSGKKPTLNIESGRITGNGGCNSYFGELTVDPTAGNFSAKNVGSTKMACDNMSVESNFFSMLNEATKYVVSGNTLELYKGNLLLLKFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N8</accession>
    <name>C6X4N8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.157</ecNumber>
            <ecNumber evidence="6">1.1.1.35</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.157" evidence="6"/>
    <dbReference type="EC" id="1.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782522.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00925"/>
    <dbReference type="EnsemblBacteria" id="ACU07376">
        <property type="protein sequence ID" value="ACU07376"/>
        <property type="gene ID" value="FIC_00925"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00925"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_10"/>
    <dbReference type="OMA" id="FYDYSES"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="185"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="32128" checksum="2F3438B98E585EC2" modified="2009-09-22" version="1">MKNIVVIGAGTMGNGIAHTFAQTGLSVSLVDVSDEALAKGLKTISTNLDRIVAKGNLTEEQKNATLSNISTFTKLEDAARNADLIVEAATENIDLKLKIFRQMDELAPENCILATNTSSISITKIASVTNRPEQVIGMHFMNPVPVMKLVEIIKGYSTSKETFDSIFEMSKTLGKTPVEVYDYPGFVANRILMPMINEAIETLYNGVAGVEEIDTVMKLGMAHPMGPLELADFIGLDVCLAILNVMHDGFKNPKYAPTPLLVNMVTAGKLGVKSGEGFYDYAESRKAEKVARMFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P5</accession>
    <name>C6X4P5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782529.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00932"/>
    <dbReference type="EnsemblBacteria" id="ACU07383">
        <property type="protein sequence ID" value="ACU07383"/>
        <property type="gene ID" value="FIC_00932"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00932"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064298_0_0_10"/>
    <dbReference type="OMA" id="RINMFLR"/>
    <dbReference type="OrthoDB" id="1238363at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014127">
        <property type="entry name" value="CHP02757"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09674">
        <property type="entry name" value="DUF2400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02757">
        <property type="entry name" value="TIGR02757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="29954" checksum="03CF9743E3EA0EB6" modified="2009-09-22" version="1">MTFNELKDFLDEKADFYNAPAFIDSDPIQIPHRFSLKQDIEIAGFLTATISWGNRKSILKSAEKMLDFMEHTPYDFVLNVSEKELRNLENTSIHRTFNGEDFAEFLRNLKRIYQQTETLENLFVLKDNETNFFHALYRFREEFIGGSSHRSHKHVSSTYKNSSAKRLMMFLRWMVRQDNTGVDFGLWKNIEQKYLSVPLDVHTGNISRRLELIKRKQNDWKTVEEMDSALRKLNPEDPAKYDFALFGLGVSKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q1</accession>
    <name>C6X4Q1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truB</name>
        <name evidence="7" type="ordered locus">FIC_00938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782535.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00938"/>
    <dbReference type="EnsemblBacteria" id="ACU07389">
        <property type="protein sequence ID" value="ACU07389"/>
        <property type="gene ID" value="FIC_00938"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00938"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_2_0_10"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="42"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="233" mass="26187" checksum="A505C9516180C6F7" modified="2009-09-22" version="1">MTDQDFLEGQIILLDKPLDWTSFQAVNKLKYKLKREFNLPKKFKIGHAGTLDPRATGLLIVCTGKFTKIIPGIQDAPKEYQTEIKIGVQTESYDTEKPEILPQDFSHITSAQINEVLESFVGEIDQTPPVFSAIKIDGSRAYDLARKGKDVEMKSRKTTVHYISEVEVELPIIRFTVGCSKGTYIRSLAHDIGQDLGVGAYLTNLRRTKIGEYSIDSASGDYLNDDFRFSAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S6</accession>
    <name>C6X4S6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00963"/>
    <dbReference type="EnsemblBacteria" id="ACU07414">
        <property type="protein sequence ID" value="ACU07414"/>
        <property type="gene ID" value="FIC_00963"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00963"/>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_1_0_10"/>
    <dbReference type="OMA" id="LFKNFAD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="24615" checksum="118ACC3AD4C8DDEA" modified="2009-09-22" version="1">MAMIFIQICGKPNPKSKKSFIFVAMDYQRLTIRGISYSQTQSGAYALLLEHEETNVKLPVVIGNFEAQAISLGLEKDIHPPRPLTHDLFSKFVHSANYTLASVIIYQIVDGVFFSNLNFRNNLGGEELILDARTSDAVAMAVRFDAPIYTTPQVLSEAGILLELDEPGAADEDLDAAREGDLASLPLEDLQKLLDEAVKDEDFDAAMELQKEIKRRNKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X2</accession>
    <name>C6X4X2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782606.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01010"/>
    <dbReference type="EnsemblBacteria" id="ACU07460">
        <property type="protein sequence ID" value="ACU07460"/>
        <property type="gene ID" value="FIC_01010"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01010"/>
    <dbReference type="eggNOG" id="ENOG50331ZJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191399_0_0_10"/>
    <dbReference type="OMA" id="VWMISIV"/>
    <dbReference type="OrthoDB" id="1980697at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="64" mass="7544" checksum="D74F5883D7A14C41" modified="2009-09-22" version="1">MKKRHKQKLVILSIILFVMFNAPVLLLFNNVQPVAGLPLIYFYIFIIWLASSVVSFLIFRKFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y5</accession>
    <name>C6X4Y5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07473">
        <property type="protein sequence ID" value="ACU07473"/>
        <property type="gene ID" value="FIC_01023"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01023"/>
    <dbReference type="HOGENOM" id="CLU_3381969_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="33" mass="3845" checksum="A9F761641FE51AFC" modified="2009-09-22" version="1">MVTSFNPLNFLMKIKNAVKRVIIIINNNIKMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X500</accession>
    <name>C6X500_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805773.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01038"/>
    <dbReference type="EnsemblBacteria" id="ACU07488">
        <property type="protein sequence ID" value="ACU07488"/>
        <property type="gene ID" value="FIC_01038"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01038"/>
    <dbReference type="eggNOG" id="ENOG5031AWU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150563_0_0_10"/>
    <dbReference type="OMA" id="WWIENGR"/>
    <dbReference type="OrthoDB" id="1791575at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13648">
        <property type="entry name" value="Lipocalin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973471" description="Lipocalin-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin-like" evidence="2">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="143" mass="16331" checksum="E98C6718BD8A5188" modified="2009-09-22" version="1">MSKILKANLFVLLVSLVFSSCSTNLLSVANGKKIDNRLVGVWSGSEKDQQLEGVEKSWDMTRNADGTFVLDFIFTQDGRSQETQETGNWWVQGNKFYEYHEESGKTDVYTYTVLNENQIKFKSESISVGMNNDGYEFIDSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>C6X501</accession>
    <name>C6X501_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_01039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805774.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01039"/>
    <dbReference type="EnsemblBacteria" id="ACU07489">
        <property type="protein sequence ID" value="ACU07489"/>
        <property type="gene ID" value="FIC_01039"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01039"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_0_10"/>
    <dbReference type="OMA" id="ALTGYHW"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016221">
        <property type="entry name" value="Bifunct_regulatory_prot_Ada"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000409">
        <property type="entry name" value="Ada"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="10">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from methylphosphotriester" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine" evidence="7">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="347" mass="39789" checksum="643FB8499D580C17" modified="2009-09-22" version="1">MELSTEIMYQASLDKNPDFEGVFWMGVKTTGIFCRPICRARKPKPENVEFFSSTKAAILKGYRPCKVCKPLENPDETPDYIQQILEELRENPAQKFKDYDLVKRGIEPSTMRRWFQKNHGMTFQAFQRMFRLNTAFKKLQQGENIIETAYDSGFESLSGFSESFKNIFGVSPKNSKTQQIIDLKRIETPVGTMYAAAVDEGICMLEFTDRKMLETEFKDLAKSLNATIVLGENRHFMVLEQELKLYFEGELTQFTVPLSPVGTQFQKSVWKILQQIPYGETWNYRRQAEVLGDVKKVRAVANANGMNKISIIIPCHRVIGTNGTLTGYGGGIWRKQKLLELEKAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X506</accession>
    <name>C6X506_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01044"/>
    <dbReference type="EnsemblBacteria" id="ACU07494">
        <property type="protein sequence ID" value="ACU07494"/>
        <property type="gene ID" value="FIC_01044"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01044"/>
    <dbReference type="eggNOG" id="ENOG503364Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199583_0_0_10"/>
    <dbReference type="OMA" id="FINDKYM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="83" mass="9761" checksum="B52F75CF7A4770AF" modified="2009-09-22" version="1">MKMERETRVSVFESENPSEVQLLKSRLESQNIQNFINDKYMSFTTTPTANTIRLMVNLQDEQKAFEIIDEYIQNSDLDLKTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X540</accession>
    <name>C6X540_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07528">
        <property type="protein sequence ID" value="ACU07528"/>
        <property type="gene ID" value="FIC_01078"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01078"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_10"/>
    <dbReference type="OMA" id="ATTHEEC"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="114" mass="13457" checksum="C9756683ACA1C025" modified="2009-09-22" version="1">MTKKATTHEECKTHMRAVHDALYVLNGKWKIPIVTTLFFHDKRRFSDILNDVEGISNKMLSKELKELEINKFLKRTVLDTQPVTVEYELTEYGRKLEPVIINLSEFGIEHRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X549</accession>
    <name>C6X549_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805822.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01087"/>
    <dbReference type="EnsemblBacteria" id="ACU07537">
        <property type="protein sequence ID" value="ACU07537"/>
        <property type="gene ID" value="FIC_01087"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01087"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043032_0_0_10"/>
    <dbReference type="OMA" id="MAKLFVF"/>
    <dbReference type="OrthoDB" id="365080at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="508" mass="56183" checksum="7261C717C4D3FC78" modified="2009-09-22" version="1">MAKLFVFGIGGTGARVIKSLAMLMAAGVDTGYDIVPIILDPDAANSDVNRTKAILDDYVKIRNKGNDNGEASFFKNKINPLGDVVKNDDKGTIGSNFVVNIDGLDNGEKFKSFIDHQSLDADNKKMIDLLFSEDNLELPLDVGFKGNPNIGSVVLNSFVNSSTFHAFANIFDKDDRIFIISSIFGGTGSAGFPLLLKNIREGNIGGNNFAYLKDAIVGAISVQPYFKIEKSEGAEIDSHTFISKTKSALYYYDHFISKSDSLNATYYIGDDSTGVYEHNVGGTVQKNNAHFVELASALAIVDFAKDQSLQSANGKALNPVYREFGVKAHEGFLNFSTVSDLTSNMIKKPLAQYFYFDLFINKMLTETMSDPYSQTKRGAHFDKSFTSTQYFNTLKSFNRAFRVWLGEMKENTVSFAPFSINVEQDSKGNINDFSYSASSEIYTYIDGSVPSKDGFLGLGKKNFELYRHTLSTVSEKEVKIFVGAEDRFLKVFSLATQELLKEKNLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B5</accession>
    <name>C6X5B5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07603">
        <property type="protein sequence ID" value="ACU07603"/>
        <property type="gene ID" value="FIC_01153"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01153"/>
    <dbReference type="HOGENOM" id="CLU_3270398_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="41" mass="4744" checksum="67BE83A33C72C532" modified="2009-09-22" version="1">MIMYGVRINFFAKNVRAYPNAAVKKTFTAQKSRKIISRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D5</accession>
    <name>C6X5D5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805908.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01173"/>
    <dbReference type="EnsemblBacteria" id="ACU07623">
        <property type="protein sequence ID" value="ACU07623"/>
        <property type="gene ID" value="FIC_01173"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01173"/>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120441_2_0_10"/>
    <dbReference type="OMA" id="NALMFWA"/>
    <dbReference type="OrthoDB" id="1925503at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="115" mass="12558" checksum="0D3B6B29E9EB6AA7" modified="2009-09-22" version="1">MNMIIRMLITAAVAFFLTKILSGVHFDNFATAIIFAIVLAVLNLIVKPILHILGLPLTIITLGLFAFVINALVILIADYFIDGMMVDGFWWALIFSIALSLITSLVSGIFNSADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E0</accession>
    <name>C6X5E0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queA</name>
        <name evidence="6" type="ordered locus">FIC_01178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805913.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01178"/>
    <dbReference type="EnsemblBacteria" id="ACU07628">
        <property type="protein sequence ID" value="ACU07628"/>
        <property type="gene ID" value="FIC_01178"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01178"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_0_10"/>
    <dbReference type="OMA" id="LSKHKMD"/>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="349" mass="40109" checksum="273EC4BB5B92A039" modified="2009-09-22" version="1">MKTSDFNFHLPEELLAEHPSEHRDDAKLMVLDRKTQTIEHKTFKDVVDYFDEKDLFIFNNTKVFPARLYGNKEKTGAKIEVFLLRELDKETRVWDVLVDPARKIRIGNKLFFTEDESLVAEVIDNTTSRGRTLRFLYDGSYEEFRTKLKELGETPLPKYIKRDVEPEDAERYQTIYAKHEGAVAAPTAGLHFSRHLMKKLEIKGIDFAEVTLHVGLGTFNPIEVEDLSKHKMESEEAIIDQLNADIINKAVAEQRRVCAVGTTTMRALETSVSSNKKIGPYHGWTNKFIFPPHDFGVANAMITNFHTPKSTLLMMIAAFAGKDFLMHAYEEAIKNEYKFYSYGDAMLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5E4</accession>
    <name>C6X5E4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Octaprenyl-diphosphate synthase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805917.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01182"/>
    <dbReference type="EnsemblBacteria" id="ACU07632">
        <property type="protein sequence ID" value="ACU07632"/>
        <property type="gene ID" value="FIC_01182"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01182"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_10"/>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="325" mass="37339" checksum="088FA906638B305D" modified="2009-09-22" version="1">MANTVDEIKVPINDEMKLFEQKFYESMQSNVPLLDKVTRFIVTTKGKQMRPMFVFLCAKLVGSVTDKTFRGASMIELIHTATLVHDDVVDESFKRRNFFSINALWKNKIAVLVGDYLLSKAVLLSTDHKDYDLLAVISRTIREMAEGELLQLEKARKLDITEEVYYEIIRQKTATLIAACCEIGVRSNSDDEVLAAKMMEFGTLTGMAFQIKDDLFDYLTSNFIGKPVGIDIKEQKMTLPLIYTLKNAAEKDRKYFLNIIRRHNTDTKRVKELIAFVKSSGGLDYAIGVMKDYQHRAKLILDEFPDSEAKRSLHLMLDYVIERKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I8</accession>
    <name>C6X5I8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01228"/>
    <dbReference type="EnsemblBacteria" id="ACU07676">
        <property type="protein sequence ID" value="ACU07676"/>
        <property type="gene ID" value="FIC_01228"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01228"/>
    <dbReference type="eggNOG" id="ENOG5030UQX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056950_0_0_10"/>
    <dbReference type="OMA" id="HFSHEKF"/>
    <dbReference type="OrthoDB" id="763366at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017601">
        <property type="entry name" value="DGQHR-contain_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017642">
        <property type="entry name" value="DNA_S_mod_DndB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14072">
        <property type="entry name" value="DndB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03187">
        <property type="entry name" value="DGQHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="410" mass="47082" checksum="516656E8E5A5BC13" modified="2009-09-22" version="1">MRHLACIRGVIGYWSYYSTVMKIRDIVENNTIITVPESEELFAHTINEILQREVNPTRTKQISHYISNNSERFFSNLIVAFHKGEPKWTEVEISNNFEVDNSLIDQDSISFLSNKFGVLTLTGDEEMFALDGQHRLLGLRAAFEEDPAIGNLEVGITFVIHKSEAIDKTRRLFTVLNKYAEKPKGAELIILDEDDAAAINSRKLVTNHPILSLPNALSNSKSGGIANNDFESFTTLVTLHKINKILYSGLPINYNIRPSDEALDELYNLSDNFWNLIFETYPELIQYINGEDNVIINDNEINRNSETGGSLLLRPVGQELLALAYTKFNTDEREILINKFRLIDFDLSSENWKYIYWNEKMLGKETKLKNDLILFLLGKNLNEANIHANMNRVYQSYGQEYNNHIYPVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I9</accession>
    <name>C6X5I9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01229"/>
    <dbReference type="EnsemblBacteria" id="ACU07677">
        <property type="protein sequence ID" value="ACU07677"/>
        <property type="gene ID" value="FIC_01229"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01229"/>
    <dbReference type="eggNOG" id="COG2958">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074541_1_0_10"/>
    <dbReference type="OMA" id="DDEQSEC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="325" mass="38079" checksum="8F31DD00D3AD38CE" modified="2009-09-22" version="1">MFLIKINYHIMTIKESILKSLEDINSLANAAEVYNHIVTKGYYQFGAKNPSALVSAMLGEFIKNGDSRIKRSKTSGQTYKYYLTKLEKTVLIDQLDIVVDKIKPKKNEYQERDLHKLLSSFLKNTDTYSKTIFHEQSLNSKDNHQKWIHPDVVGIQFLNLHSKINQTFLKAINKLDIFKISSYEIKREINSDYELKKTFFQAVSNSSWANYGYLVAFEISDSLNEEMERLNQSFGIGIIELKANPYESKILFPAKYKDLDFKTIDKLCKINKDFEKFIEQIEKLMTASDKYYKSTEKELDEFCDSYFLNDTEIDEYCKEKFIPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J0</accession>
    <name>C6X5J0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805963.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01230"/>
    <dbReference type="EnsemblBacteria" id="ACU07678">
        <property type="protein sequence ID" value="ACU07678"/>
        <property type="gene ID" value="FIC_01230"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01230"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002964_1_0_10"/>
    <dbReference type="OrthoDB" id="1128at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017646">
        <property type="entry name" value="Dnd_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03237">
        <property type="entry name" value="dnd_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1736" mass="200112" checksum="D7B389A245A07883" modified="2009-09-22" version="1">MRKKVIAEMHNTSSQLYSYVSNLIVEYFSLQQILYGDRFNLYLEDNENIEMLYEALKTIPETSANSFSYTHPEGGEVYNTFYLIIGTTKLIIASSTLASEDYLTMLRNKIADQDDIFYGTAILILFSGKLDSLLGGSGSLIKEGMPLHYTRFKDKIEQDIDRSTSLKSYEKNILKKVLERKTKSVVEDNNSIFDYEQVINSLQKGSIEQIDYRNLGLFPHQELSTKTGDLTADLTGNFNLYDRFENIFTNGNPATDLEQELPSSALAKITKEDWHDIDYAQLVKWMDKEKEKAPPVFQSIEGDNLLQTLWYKTDGDSVSKKRNVNLIVFNPSLELPFKINVRYDQFIRKEGINIKQGSDKIKAIASGYNIIIEFNEFDSDKLFSLIEYRDSETEKRYLIKILHLPFDSHVLSQFEGNFHFNVQNSKSYLQIKESEKLIFNPNAETIVEEILAIDSHFKLVEEQQLSVNYDYSLAQEDLIHFKIELFDVLVPIAIKTDFEMPKPITGLDVWKEKRIQGLNFKYLKEGSIIKLLFKNNEKTVSGEFRNNLIQEEQIINSEGHSWFLGNDNAIYNRELNLNTDIKKAFDNLRNHYKNKKTQPSLVFLDTQLKELSLAYVTCFIDQLEKFEENKPLTYEQKNLLWLGVVKEQNGEEKIKFSPLHPLNVAYQLELDNHLKEEELYNAVLKRLSPYNLIPYLEGKQNEIYIPIESSHSPEWLYYTVYLNSKQAVPKSFVSNLITDKIKDFTTNFESLFHQSKKAPIKINVINLGDCKEVVEGIFEFYRKFLNTNLNKRMTDLLPIEVNIYGSEKLVNKFEELTFYEKVDDVERYLELDLKTKNFEREDLLNAFLERVKFYTKKHPEKTERYEYAHITFYQFDVTQTEISYDDMSLVKTGLSFNGLMADVTSTPRVQNYRTGFGTKDLPEQRNDLTTLSCLYNSFVRVANNGDPYESNKAICTTINYDIKEQLVKLYSDSQWVTYIDPKVDLDFFKENKDLVIIHYSDQYNNSNGYDAITVSRKTSQYEFVVKEFLEKHSVKFDPSTDTINIINFFNAINGEWLLKLIRQHSQFPREKLSLLSGIKTSLTFLYHPDIIWIPISLEEILRVSGNAGLNMGDGLFSTKNLGAIGSFSDDLLFIGLENLDGALLMHLYPVELKIGGPGIVKKGIDQGKRTAELLKEHLHKPGFLSDFYKNFFAKIALTNAEKMKLFHVWDTQNWNVITEDYRKDLLNNNFTISNRLNKSLGNFGLIYFGSDVYKRELHIKEGFMRVNLQETDGYNFLVKSVDDLIHLFLKTETTIEKSKLLINTYSTATTDFLISGHSAFDEAQLKEEETDIAELTNTEQDTATTVDDITTVQNTSEGIEIEFGTDLNNFKTIFWEPNNTNKVMHTNTGIIGTMGTGKTQFTKSLITQLNVHANKNIGDEKLGILVFDYKGDYIKEDFVNKTNAKVLHPYHLPYNPLALDATQNSKPMLPLHTANDLKETIANAFNLGNVQKQRLRDVIIEAYEDKGIIKSDKNSWTRTPPTLGDVCDIYLSSEKNSQDSLYAAISNLSEFEIFEPDAAKAQSLYSLIEGVVVINLSGYDESIQNLIVAITLDAFYSQMQRHGHSKIDGSKREIKKMILVDEADNFLSKNFHSIRKILKEGREFGVGTILSTQFLNHFATGENEYSNYILTWVIHRVNEIKMKEVESLFSLDNKLQKENLIKTIKGLEKHQSIVNLAGSEPILIKDKAFWELLNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J9</accession>
    <name>C6X5J9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix-domain containing protein, AraC type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805972.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01239"/>
    <dbReference type="EnsemblBacteria" id="ACU07687">
        <property type="protein sequence ID" value="ACU07687"/>
        <property type="gene ID" value="FIC_01239"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01239"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030864_0_0_10"/>
    <dbReference type="OMA" id="DNDARAY"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="439"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="555" mass="63519" checksum="E3E4CFB9A1619A62" modified="2009-09-22" version="1">MLRFSILIWPLLLFAEPYLAQRKENAAYQQIRNQYAQMQPGDPAAFPYINLVLSLAKKEKNYAELAAGYRDALNFHNSVYDQLLYADSAIAAAHRSCDNGVIANAYMGRGIVHYSGLKDYQRALEDYLMAVDYVRSDEDPYLQYKLLYHFGVVKSYTGLHQDAAVNLEACAAFFRKELQKEQPPNLLHNLRKGYYNSLHQLVTCYQQTGRDDKAARMIALAEKEIPDGPAFSVVRSCFLKSRGISEYRKGNRKASIHALNLALPELIRTDDFASVSVIYYYQGKNALALKRKEEAVSLFKKVDSVFQRHHFIFPELQHAYHYLIRDADKRRDSREVSYYYEALRAAETVNHEDRHYLFARMRDAQHTDEKRSAENRFAVTLIALITVSVGAAAFTLEKLGKKNEPSLSYASAGDGPGTAKYEELQTSEPKWKLAADTREKIRRNLQKFEEDKSFLEPKVNLRKVARRVGTNANYLSTYLNTEKGVRFHRYLSERRISYIAAQLAGDPAMLEKGTQELAVSCGIMSSSNFLHLFSEIHGTSLSEYREQCRKKFAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K3</accession>
    <name>C6X5K3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01243"/>
    <dbReference type="EnsemblBacteria" id="ACU07691">
        <property type="protein sequence ID" value="ACU07691"/>
        <property type="gene ID" value="FIC_01243"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01243"/>
    <dbReference type="HOGENOM" id="CLU_3200105_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="45" mass="5029" checksum="3F35BC9A35B81651" modified="2009-09-22" version="1">MLTDYNQAGNSKHFRPQVLHASALAGRLLRRITAAAFNLINLHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L0</accession>
    <name>C6X5L0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01250"/>
    <dbReference type="EnsemblBacteria" id="ACU07698">
        <property type="protein sequence ID" value="ACU07698"/>
        <property type="gene ID" value="FIC_01250"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01250"/>
    <dbReference type="eggNOG" id="ENOG5033QBK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569555_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970704" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="411"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="479" mass="52430" checksum="1FF0193B875BCBFE" modified="2009-09-22" version="1">MMLRGNYNSILALLNTLLFMKNKLLMMLLAAGSLMAAQTNDCSFGVASENTGNGGNISTGGNYEYSSATDFDVDFGTIFTAKQVKFHAIKGAADVQYVKINFLKEVEGMPGASIKSFSQIVPTSQQFLSALDIEGMDQYLITVDLPTEVDLPKGKYFLEIQAAPGDEYMVAWEIAGEDTKKLGRFDMGKFGDEPWSGGFSYYDQVFQISGSCAPTGQEPPAYGQPASQGNPSNGYETAFSLGGFNMADDFIVPENTTFYLNAFKMSSMQLGNMINATVKIRKENNGAPGDVVYTAEKKGPKTENFYGYHPLDGYPLEVVAVDLDFEFDEAIELQAGKYFLEIQANPVPYTDLLTWEATTAPGIGGSLFWSTDDGETWTPQEGYNFVFDVYGFSKSTLGTADDSQQDEVVSYPNPARDQLYIDSKTPVKNLSVYNAAGQLITKLKALNGKTDVSTLQPGVYFIKAELQNGTEKSFKIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P8</accession>
    <name>C6X5P8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase families S8 and S53 domain protein</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806021.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01288"/>
    <dbReference type="EnsemblBacteria" id="ACU07736">
        <property type="protein sequence ID" value="ACU07736"/>
        <property type="gene ID" value="FIC_01288"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01288"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709294_0_0_10"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973490" evidence="1">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="322"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="389" mass="41050" checksum="4E34FB7D0E227CDB" modified="2009-09-22" version="1">MKKLYLLAATAIVGFTLAQNRPSDAQMAPIFAKMNAVSNPAAPEPHGFFTEEEGNLIRAYYAHDAGTPSVSTAALANNDAHVLDARNVSRPYGHFPYLGPYTLTVTGTIPSTRAVYSDDYDQNGTLYALDNTSRALLIVNPADASVTQVATITGIPAAETLGGLAFNYVNNQFYVLGSTTLSTQLYSLNPTTAVATPIGSIPGILGIWLVIDNDGNAYTADLTLDNLLQINLTTGTAAVVGPLGININFAQDADVNTADNTIYMAAYIGAGVGGIYSVSKTTGTATLIGSTTANNAEYTMFSIENPSPLAVDDSSVKNALQIYPNPVKDVLNIATKAKIENAEILNLEGKLVMKTKASQAIDVSSLRPGVYILKAAVDGRIQTVKFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S0</accession>
    <name>C6X5S0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin, type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806043.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01310"/>
    <dbReference type="EnsemblBacteria" id="ACU07758">
        <property type="protein sequence ID" value="ACU07758"/>
        <property type="gene ID" value="FIC_01310"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01310"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042641_0_0_10"/>
    <dbReference type="OMA" id="ISECDWS"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973491" evidence="1">
        <location>
            <begin position="22"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="497" mass="55039" checksum="ABCE6B730B32A8B6" modified="2009-09-22" version="1">MKNILNIFTISLLMLLLNSCSEDLVSKVQTGTLKGTVIKKGTNQPLKNVKIYTAPSTETVFTKEDGSFQIENIPLGDYSVRAELSGYLTNLQGISLQNSAQTVSVVFEMSDDESLNSPPSASVLLSPVDNAVDQPLSVDLSWLSTDADSLDVLTYKLVVKNDFDQNVLEIKDLTEKHYFLENLKFGVTYYWQVTVDDGVNPAVNSPVFRFKTSAIPNNRFHYVKKMDGNYYIVSSNEANTNFQFTPISANSWRPRLSQNAGLIAFLRTVGGSAQIFTAKPDGSQPFQVTTIPVSGFNNAETDFSWSTNGKEFLYPSFSKLYKINKDGSGLELIYTTTDGSFISECDWSYDGSKIAIKTNDPNGYNAKILVIDMQGNTVKTVLENVAGAVGGLNFSVDGNLLLYTYDISGHQDNSYRQLNTHIFIYNLTNDVRTNISLASEKPDGSNDLDPRFSPNNAEIIFTNTSNDGISVKNILKITLQDNERTALFSDAEMPDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y5</accession>
    <name>C6X5Y5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01375"/>
    <dbReference type="EnsemblBacteria" id="ACU07823">
        <property type="protein sequence ID" value="ACU07823"/>
        <property type="gene ID" value="FIC_01375"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01375"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281618_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="215" mass="24994" checksum="E1D17539E6AA6582" modified="2009-09-22" version="1">MANLYWTNTELSQISPAKFVRASMSVPFFFEPMVTKINNSKDSIIHAWKFWLNTEPANVCDEGVFIDGGSISNFPIDIFHESDIFYPRVPVFGVRLMDQAEMGEARGFGSRVILKSPLSFFGNIFDTLKGFNDKTFLTKYTFYSSHSIQFVDCSPSNWLNFFMEDREKTELFNKGFRAGLDFLEKFDWQKYKYERMLVAMKEKNILKQEAHPNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X686</accession>
    <name>C6X686_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage shock protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806209.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01476"/>
    <dbReference type="EnsemblBacteria" id="ACU07924">
        <property type="protein sequence ID" value="ACU07924"/>
        <property type="gene ID" value="FIC_01476"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01476"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_15_4_10"/>
    <dbReference type="OMA" id="EMDGNIE"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="95" mass="10698" checksum="CB41DAF840F2B1C6" modified="2009-09-22" version="1">MSLVEVLQAGDYHLIDVRESMELEMDGHIEEAQNIPLGELEERKQEVVNLSGTKIFFCRSGNRSGKAVEYFKQQGMTDVYNGGGYQELKAVLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D8</accession>
    <name>C6X6D8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806261.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01529"/>
    <dbReference type="EnsemblBacteria" id="ACU07976">
        <property type="protein sequence ID" value="ACU07976"/>
        <property type="gene ID" value="FIC_01529"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01529"/>
    <dbReference type="eggNOG" id="COG2921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175559_0_0_10"/>
    <dbReference type="OMA" id="YKFIVPS"/>
    <dbReference type="OrthoDB" id="2028648at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007454">
        <property type="entry name" value="UPF0250"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027471">
        <property type="entry name" value="YbeD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04359">
        <property type="entry name" value="DUF493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117991">
        <property type="entry name" value="SSF117991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="102" mass="11978" checksum="02A9F97A67BA65B9" modified="2009-09-22" version="1">MTNLENQKENVNPDDFYASLKEKLEATHDFPEDYLFKFIITNEESKHTEIYRVFDDIKFTLNTRESKNGKYTSISMNAFVMDADQVIRIYRAVGQIQGVIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G1</accession>
    <name>C6X6G1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system sensor histidine kinase</fullName>
            <ecNumber evidence="5">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01552"/>
    <dbReference type="EnsemblBacteria" id="ACU07999">
        <property type="protein sequence ID" value="ACU07999"/>
        <property type="gene ID" value="FIC_01552"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01552"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012730_0_0_10"/>
    <dbReference type="OMA" id="NDIINHI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="291"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="420"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="639" mass="72319" checksum="8308DDE2BC54245D" modified="2009-09-22" version="1">MRFLFHKKRNCRNIQIYTKFVLMKNFLQDHLSFDSLVTLFSQAPVALAMLMGDEQVVQVANRQILDLWGKDAGVIGLPIIEAIPEIRNQDFPILLKKVYETGIPFSGDGVPATLIKEGVPTLCYFDFVYSPIYEAGKISGISVVATEVTDKVLSEKKLLESELRFKELLLVSDYSTAIYRGRDLIIEFANDQMIRSWGKNSSVIGKKLEDAIPELAGQPFVQILKDIFETGKPYIAKEDEVHLDVDGKLQTFYFNFSYKPLRDASGGIYAIMNVAVDVTELVNAREKARANENEYRTLAEAMPQMVWTAVPSGKIDYCNRNMCEMLDCTAEELAINDFTDIIHPSDLRLMKALWKEATEQKESFEHEYRMRDHRTGQYSWFLGTATPVMDNDEIVKWIGSCTNINEFKNLVTQKDTFLGIASHELKTPLTSLKLYAQVLERMLAKSGDQKHADLAKKMDLQVVKLTSLIADLLDVTKINAGKIHLNEAHFDFKSLVEETVEEQQMSTLHTIEVEELAGGMVFADKERISQVMTNLISNAIKYSPQASKIIVKTKKVDGDLVFSVTDFGIGLPRDTMHRVFEQYYRVSAEDQNTFPGLGLGLYIAGQIVERSNGKIWVESEIDRGSTFYFSLPLVQSSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC7</accession>
    <name>C6WZC7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitric oxide-dependent regulator DnrN or NorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782108.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00503"/>
    <dbReference type="EnsemblBacteria" id="ACU06961">
        <property type="protein sequence ID" value="ACU06961"/>
        <property type="gene ID" value="FIC_00503"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00503"/>
    <dbReference type="eggNOG" id="COG2846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076075_0_1_10"/>
    <dbReference type="OMA" id="ACTTWRV"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019903">
        <property type="entry name" value="RIC_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36438">
        <property type="entry name" value="PTHR36438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04405">
        <property type="entry name" value="ScdA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03652">
        <property type="entry name" value="FeS_repair_RIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="80"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="237" mass="27628" checksum="430007C7D88037CF" modified="2009-09-22" version="1">MLTQEKTIGDFVAENFRTAEVFKKYHIDFCCKGGRTVEEACDKKNVNAEDIYRELEEITKEKSSDIDFNSWPLDLLADYVEKTHHRYVEEKTAMLIPYLSKLCKVHGDRHPELFEINELFLGSAQDLAAHMKKEELILFPFIKKMVAAKRSGEKIEKPHFGTVENPVAMMKDEHEAEGDRFVKISELTNGYQFPEDACGTYQVTFKMLEDFENDLHKHIHLENNILFPKAIELEKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD1</accession>
    <name>C6WZD1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782121.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00516"/>
    <dbReference type="EnsemblBacteria" id="ACU06974">
        <property type="protein sequence ID" value="ACU06974"/>
        <property type="gene ID" value="FIC_00516"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00516"/>
    <dbReference type="eggNOG" id="ENOG5032WHU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146561_1_0_10"/>
    <dbReference type="OMA" id="RLMKNHI"/>
    <dbReference type="OrthoDB" id="1850613at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="100" mass="11731" checksum="51978D16DA2DF16F" modified="2009-09-22" version="1">MLKDLENNFSVLEKKILSVSKNYQSLTEKYSILFEEHEALKTKYDEERKKNQVLAEEQKNIKLYSAISGNPDHNRLMKNHINRLIKEVDHCIAELQNSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK9</accession>
    <name>C6WZK9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit omega</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781691.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00068"/>
    <dbReference type="EnsemblBacteria" id="ACU06544">
        <property type="protein sequence ID" value="ACU06544"/>
        <property type="gene ID" value="FIC_00068"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00068"/>
    <dbReference type="eggNOG" id="ENOG5032SSJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140821_0_0_10"/>
    <dbReference type="OMA" id="FYERMPK"/>
    <dbReference type="OrthoDB" id="2012249at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="107" mass="12462" checksum="24291CF26CA59B5E" modified="2009-09-22" version="1">MSAKDSKAELSTITYDKDKIEENVGSIYEAIVIMGKRAEQINAEIRSELHNKLDEFAVHNSTLEEVFENREQIEISKHYEKLPKPTSIAIKEWLDGEIYYRNTDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM6</accession>
    <name>C6WZM6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ordered locus">FIC_00085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00085"/>
    <dbReference type="EnsemblBacteria" id="ACU06561">
        <property type="protein sequence ID" value="ACU06561"/>
        <property type="gene ID" value="FIC_00085"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00085"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_2_10"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="18"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="399" mass="45120" checksum="0EED35A2A07A9B85" modified="2009-09-22" version="1">MTDKDLLKIAEQYGTPTYVYDAESIKEQYEKLTSSFHKSTRFFYACKALSNINILKYVKNLGGSLDCVSINEVKLGLKAGFEAKKILFTPNCVDLAEIEEAMALNVHINIDNISILEQFGNKYGGSYPIFVRINPHIFAGGNYKISTGHIDSKFGISIHQLRHIERVMKTTNLNVEGLHMHTGSEIKDPDVFLQGLDIMFELAEHFPNLKYLDMGSGFKVPYQEGDIETDVKTLGKKVEKALSEFSKSSGKKFELWFEPGKYLVSKSGNLLVKTNVIKQTTATVFAGINSGFNHLIRPMFYDSYHKIDNLSNPKGAQRIYTVVGNICETDTFAWDRKLNETREGDVLVFRNAGAYGFEMSSNFNSRLKPAEVLFLDGAAHLIRRRDEFEDLLKNQIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN2</accession>
    <name>C6WZN2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00091"/>
    <dbReference type="EnsemblBacteria" id="ACU06567">
        <property type="protein sequence ID" value="ACU06567"/>
        <property type="gene ID" value="FIC_00091"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00091"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2206159_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="107" mass="12200" checksum="809BB3C34A806697" modified="2009-09-22" version="1">MCVLTKLCEMNILDHISFSPDKPNVHYITKNERIRCFAVALGNGAVLKKHSTPVPATLIVLKGEINFAFSDREYVLRAYDTFEIPVDEIHEVFGITDQNLFLVTQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP6</accession>
    <name>C6WZP6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00106"/>
    <dbReference type="EnsemblBacteria" id="ACU06581">
        <property type="protein sequence ID" value="ACU06581"/>
        <property type="gene ID" value="FIC_00106"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00106"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467515_0_0_10"/>
    <dbReference type="OMA" id="KVRYAYY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="572" mass="65060" checksum="01BC1C72C1C9AFE0" modified="2009-09-22" version="1">MICIIFAKRYTMVNSRARETTEAIERLYVSMRHLFYRGFFKPSGISGESLRSLLMIINPEIYGTMGVPNKIELNGLLYVLDRLPEGIEECSFIHLTSDEGFEKGSFEVIVPKKRRRNCYRIDEHQMNIEVLLGRSEIYDILTHLTFLYIEADKIRSLAFISDENDKPTRAWKIIEEVAKGEKKYSRKEKEVALIHLSSLLGRTFDETLNAYNSFGDDANPDRLFKIIYHLGNESFNDDKKIREREVHFSAILRERVGHHFFGEKWANKVKTVLAENNLQMRPLHIISANMHSVKNMLYGNDALGKKATKSVDFKLYEDISNKKSLQEKVLTHSQNAGLIYIDDQSGSNIDVQIIDLAKTDLTNTPFADLNFEADDVVMVFDYAFGEQAYEVMDELLRPYEFNEEVYTMKVKSISIMGKAGILMGGKGDIMIPTSHVFEGTADNYPFENALSLADFEDDELQAFEGGMVTVLGTSLQNKDILRYFMDTSWKAIGLEMEGAHYQKAIQVASKIRHHISEDLFVMYAYYASDNPLETGSTLSSGGLGLTGVKPTYLITLKILEKILASGKTPMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP8</accession>
    <name>C6WZP8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ordered locus">FIC_00108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781730.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00108"/>
    <dbReference type="EnsemblBacteria" id="ACU06583">
        <property type="protein sequence ID" value="ACU06583"/>
        <property type="gene ID" value="FIC_00108"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00108"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_1_1_10"/>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="253" mass="28028" checksum="167AA48C99FD3F0E" modified="2009-09-22" version="1">MTTIVINIGNTNIRFGVFVNETCDSSWIINTKPYRTSDELQMQFMMMYQTHHIEAAKIDRIIIGSVVPQLTYDVTRALKKMHGLNPIVVSRETPSGVQPKSKQMGTDIYANLVAAHHLYPKGKKIIFDFGTALTASCIDEKGETLGVIIAPGIITSLNSLIHDTAQLPEIELIKPKKVLGLDTVSCMQSGMVYGYLGMVEGFIDRINAEVNEDCFVIATGGVSHVYKPLTDKIHVGDRLHTLKGLFYLGKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ4</accession>
    <name>C6WZQ4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CsaA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781736.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00114"/>
    <dbReference type="EnsemblBacteria" id="ACU06589">
        <property type="protein sequence ID" value="ACU06589"/>
        <property type="gene ID" value="FIC_00114"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00114"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065946_2_1_10"/>
    <dbReference type="OMA" id="FPEARNP"/>
    <dbReference type="OrthoDB" id="2038415at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008231">
        <property type="entry name" value="CsaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="PTHR11586:SF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02222">
        <property type="entry name" value="chap_CsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="114" mass="12712" checksum="0DE5BA9B2DC1449C" modified="2009-09-22" version="1">METKPLISWQDFEKIDIRSGTILSVQEFPRAKNPSYQLEIDFGPLGIRKSSAQITAQYSKGNLVGQQILAVVNFPKKQIANFFSDCLVLGIYNENEEVTLISPQLPVNNGLQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT8</accession>
    <name>C6WZT8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type cbb3 cytochrome oxidase biogenesis protein CcoI Copper-translocating P-type ATPase</fullName>
            <ecNumber evidence="6">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.4" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781770.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00148"/>
    <dbReference type="EnsemblBacteria" id="ACU06623">
        <property type="protein sequence ID" value="ACU06623"/>
        <property type="gene ID" value="FIC_00148"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00148"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_10"/>
    <dbReference type="OMA" id="CKTVYEI"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021993">
        <property type="entry name" value="ATPase-cat-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12156">
        <property type="entry name" value="ATPase-cat_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="5">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="797" mass="89518" checksum="CB926EDC83C9A425" modified="2009-09-22" version="1">MSENCFHCGQNIIKERIPFDDKVFCCAGCKSVFEILNANDLGTFYELNKRSGIRPDGAQNSQFDYLDTPEIFDKVTDFSEGTTTLVNFKIPVIHCSSCIWLLESLHTLNSNIHYSQVNFTRKTVQISFNSEELKLSELAKFLTNLGYKPVITLESAERKEETYDRSLLLKLAVAGFAFGNGMFFSYPEYAEQLMGTTDFWMEKYKHLFRFITFTLATPVVFYSASGYFQSAWYGLKNKVVNIDVPIVLGIIMLYGRSIYEILTDYGPGYFDTLCGLLFFMLLGKLFQKRTYSALSYDRDYKSFYPIAVTKIDFNGKRENILLSDLEVGHRIMVRNQEIIPVDAILISGEGNIDNSFITGESASVPKKPGDRIFAGGKQVGSALELEVIKTVNQSYLTQLWNKEAFKKHETGLDTLTNTISKYFTFIILGITLIAGIYWSTIDFEKMFQVVAAILIIACPCALALSAPFTFGHVMRILGRNKFYVKDTLTIEKLAKINTLVFDKTGTITHSSEANITFEGEEIGEQDLKNIKTLLKNSNHPLSKSLYDFISVDDEYFPVTNFVEVAGKGYEAEVRGNVYKIGSAKLVGAESKNLETAVFISKNGELLGKFIFKNEYRKNLAGLFRHLKQYAVHILSGDNSSEQQQLKDIIPDSRGMAFNQNPEDKLNYILTLQQNGEKVAMIGDGLNDAGALKQSDIGIAVADDTHAFTPSSDVIMAGEKLPLLNDYLLYAKDAMTIVKMTFAISFFYNIIGLSFAVTGNMSPLFAAIIMPLSSISVVIFTSVATWWRSTKYFKLITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV0</accession>
    <name>C6WZV0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781782.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00160"/>
    <dbReference type="EnsemblBacteria" id="ACU06635">
        <property type="protein sequence ID" value="ACU06635"/>
        <property type="gene ID" value="FIC_00160"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00160"/>
    <dbReference type="eggNOG" id="ENOG5032QVS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105856_0_0_10"/>
    <dbReference type="OMA" id="HAYIMND"/>
    <dbReference type="OrthoDB" id="1951208at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="251" mass="28762" checksum="8684913EAC05DEB8" modified="2009-09-22" version="1">MKFALKLVLICYPFLFSAQKNGSASKVPVKTTIQKTVDAAVKADSDKINEEIPALIPQKAGGKYGYINQLGKVVIPHEYSNVGFFAEDCNLLSSPNAKAKKFGTAKYASVRLNGKDFRINQAGKRVYLFKDSDLGKCPREFKSQLFHAYIMNDRYGIIEDARFEHPGDYRQFTIYPQYDYLHIMEGEDLHNPMIVASKNNRFGVIDINNNIIIPFEYSDIKRNYSWILARLFEVTKDGINYYYVDRQNAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY9</accession>
    <name>C6WZY9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781821.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00199"/>
    <dbReference type="EnsemblBacteria" id="ACU06674">
        <property type="protein sequence ID" value="ACU06674"/>
        <property type="gene ID" value="FIC_00199"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00199"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_4_2_10"/>
    <dbReference type="OMA" id="IRFQDCD"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="164" mass="19166" checksum="B04FACD472BDCB5E" modified="2009-09-22" version="1">MQKELSSVAKIRFSDCDPIGHLNNVKYLEYMLNAREDHVEHGYGFTYEEYTRRTGCTWITIQNEIAYLKEVRYNAKVIITSKTIEISDRISKVEILMMSEDGKTVHSILWLTVIYFDMKTRQSAVHPPETKELFTRFLMDLEEKDFQSRVGTFRRANKVAAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ0</accession>
    <name>C6WZZ0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781822.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00200"/>
    <dbReference type="EnsemblBacteria" id="ACU06675">
        <property type="protein sequence ID" value="ACU06675"/>
        <property type="gene ID" value="FIC_00200"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00200"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_2_10"/>
    <dbReference type="OMA" id="AGETTWH"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="3"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="286" mass="32366" checksum="48905380E675B030" modified="2009-09-22" version="1">MKKILVVGGNGQLGNCFRKIEPDFENQFEFNFTDSETLDITDSSAVEEYFAEHRPHFCINAAAYTAVDQAENEPEKVFAVNAEAVGNLAEACAEYKTVLIHISTDYVFSGDTQISYSEDGFTDPQGVYGASKLKGEELALENNPKTIVIRTSWLYSEFNKNFVKTMLNLFAQKDELGIVNDQFGQPTNANDLADAVMRIILTEAKTFGIFHFSNYPETTWFSFTQKIAELSNSNIKLNPITTDQFPTPAKRPKRSTMSLDKIESTYRIELQHWENSLEKCIEILQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X031</accession>
    <name>C6X031_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GreA/GreB family elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781863.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00243"/>
    <dbReference type="EnsemblBacteria" id="ACU06716">
        <property type="protein sequence ID" value="ACU06716"/>
        <property type="gene ID" value="FIC_00243"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00243"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120358_1_2_10"/>
    <dbReference type="OMA" id="MIKDHIR"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GreA_GreB" evidence="1">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="127" mass="14682" checksum="0FCEA6F93A4EF3A6" modified="2009-09-22" version="1">MSEQIILTTGIYDAIKDHVRRKKVTAEEESRILAELRGAKQVRRKELPEDVVTVDRKVRIKDHTQNKEQEYIFVGIAEAKPKRNKHSILSEMALATVGYKVGDVIEWPFEGGERKIEILKVEPWSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X070</accession>
    <name>C6X070_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00288"/>
    <dbReference type="EnsemblBacteria" id="ACU06755">
        <property type="protein sequence ID" value="ACU06755"/>
        <property type="gene ID" value="FIC_00288"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00288"/>
    <dbReference type="eggNOG" id="ENOG5032SWY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499553_0_0_10"/>
    <dbReference type="OMA" id="QTSGWHI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="551" mass="63199" checksum="3EB97D5B50B4C8A7" modified="2009-09-22" version="1">MLIFKQSFFMLYLLFSLIMLLAVFAGFGGAAQKFSGKSVHGLSGTLLAGIFSVSIICTLSAFIFPLNIYFETTLLIVGLAAFFYFKIYEDFRRFFKGLPYLFYVLVFVVLFFGSGFPFILDHFGYYVPTIRWISEIGLVQGISNLDLLLGQMSVWHILQAAFSQFTDPFLRLNSLALIIYLIYIFEKKSWIHLVFVPVLFLFVQSPSPDLPAIALSLIILNELLRGHRSYGWLFALSAFVFALKPTLVWLPLFTFIYIVWIAKKNVKVLTPGIAVVLIFVFKNIWTFGFPVFPVAVLDLGLPWKPNMQLLLNSSAVAIERTFDMQFSANEIHNFSLTEYVYNWFFLPGIKGKINLLFIFSLLIFLVFSIKKNSKTIWLLFGAVLVKSVLVLMFSAQYRFFLDVFFVIFFIVGYEVFTKKLSLAIFAVMSVVVGTFISYPEFIRTVFPSFRLGSVVMGFRSAQLIEPAHYKLEKFKTYQVGNLKFNVVDGYPYSFDTPLPAILPAFIQEDLDAGIFPQLKGTTLKEGFVWRRITEQEKIQLQHIIDEFNSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C3</accession>
    <name>C6X0C3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781955.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00341"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06808">
        <property type="protein sequence ID" value="ACU06808"/>
        <property type="gene ID" value="FIC_00341"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00341"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_33_1_10"/>
    <dbReference type="OMA" id="VRICHSH"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="384" mass="42696" checksum="D038784BD0CAA632" modified="2009-09-22" version="1">MIKVLHVTGVMNRGGAEVMLMDLYRNIPSDVHFDFLVNYRKKGGLPKGDFDDEIKKRGGDISFIPSQWDLGPLGYIREFRRIIQENKIPDIVHIHMNSKSGVIAWAAKKAGVKRVIVHSHANLKFRGSLPSRVFAHTEFFFQKILIRKFGDYYWGCSAEANRSLFANITLSPDNSAIINNAVDLASFSEVSIEAVTESRNSYGNTGSLIIGNVGRIVRHKNVLFIIELLNELQKQGGNFVFVFAGRADQQSYLDEIFAKTAEYGLKDRVKYLGLCEDVPHLMKTFDVFVGPALKEGFGMVAVEAQAAGIPTILYTGFPKSVDMQLGLATFIDSFNINEWVEALTAALKNKTPTAATVNTKIKSLGFDSAVNADRIAMMYKKIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D1</accession>
    <name>C6X0D1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781963.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00349"/>
    <dbReference type="EnsemblBacteria" id="ACU06816">
        <property type="protein sequence ID" value="ACU06816"/>
        <property type="gene ID" value="FIC_00349"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00349"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_1_10"/>
    <dbReference type="OMA" id="GPYIWGG"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="431" mass="45455" checksum="76268B5A074A6812" modified="2009-09-22" version="1">MKKRVVITGLGVVSPNGIGKSDFNKAIKEGRSGIRHLKELEELKFESQIGGLPPVTEAHIAKYFTELELRKFNSDAILYGVIAGMQAWADAGLDLNAGSEPDWDSGAIMGIGSMAANKMREGTMAVDGLKVKKLGSNFVIQTMPSGVSAYLAGKLGLGNQVTTNSSACATGTESILMAYERIANGKALRMIAGGTNEGGQYAWAGFEAMRVATYKHNHEPERGSRPMSADASGLVMGAGAGALLLESLDSAMARGAYIYGELLGGQMNTGGQRGDGSMTLPNSVGVQRCIKEALANAGVEGHEVDAINGHLTSTGKCSLEIQNWSDALNRSGRDFPYVTALKSMIGHTLGAAGGIESVAAVMQLDEGFLVPNLNCEILDPAIAKIVHEDSIPRAFLKKDLNIIAKSSFGFGDVNAVIIFKKYGDPCSEMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D5</accession>
    <name>C6X0D5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781967.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00353"/>
    <dbReference type="EnsemblBacteria" id="ACU06820">
        <property type="protein sequence ID" value="ACU06820"/>
        <property type="gene ID" value="FIC_00353"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00353"/>
    <dbReference type="eggNOG" id="ENOG5033QG5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1292803_0_0_10"/>
    <dbReference type="OrthoDB" id="1390231at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24937" checksum="115760A650411182" modified="2009-09-22" version="1">MKKYLTLLTIFVLITASSQNFKYGLTGNFHRGSVAGVHDYSIGKYGGGLGLFAQWSLVENDVFDSAWLYITPQIEYNMQGEHAEADRDLFGLQKYHYDYIAMQVYLKWFFHQGNMKRDVFLFAGPRVEYMVRQDTEVDPAYNEAYYQYNLDDEVEKFGYGVSMGIGLKVSQHLEGFLRFDRGFSKVYTNNVNNNTYNRMIAVGLNYYFDENWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D7</accession>
    <name>C6X0D7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tyrosine-protein kinase wzc</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00355"/>
    <dbReference type="EnsemblBacteria" id="ACU06822">
        <property type="protein sequence ID" value="ACU06822"/>
        <property type="gene ID" value="FIC_00355"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00355"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_6_0_10"/>
    <dbReference type="OMA" id="ETSARLM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="8">
        <location>
            <begin position="604"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="797" mass="87716" checksum="4A14C3FD05A34840" modified="2009-09-22" version="1">MDPLRRGSAGPCNTHHHANPIIAHMELLENAAPVQRAKPLNIKKEIAKYLRKWPWFLLSIAIFYTAAKIYLRYAEPLYYSKTSLKLQESKGKSTALSDLKNLGMGVSGDNELQGETTVIVSKPILAAVTKNLNLAVSFYSIGKIKEVELYRDSPVTGKIISLNEPDSFGALEKTMTPVGQNSYKLSGISSVFRFGTPAKLSFGTVQIDAKPGATLSAPLKVVFRNPTHVAGALEGRINVSLPENKGLLMELALVGPVPKKSEDILNEVSRQYIIDGINDKNEEAQNSQDFINERLEIITEDLSGIEGQKESFKRSNQIVDLESQASMALSKADENTKQVVTNSMQLDLVNSVLSAAGTGDQLLPSGLGLNSTAETTISEYNSLILTRNRVLKQATPENPTVIEINKQLAALKNLIRKNLTETRETLQLQIGQANAELNVAKGNISKYPTQEKMFRSIDRQQTLKEQLYLYLLQKREENAITLAVTAPKAKIVNPAFTTGIVEPKYTQILYGSVAVGFLLPLLLFVGLNVLDTKVHTKEHILAHAPDAAVIAEIPLNPAENAMVHPNDFSVFAESFRILGSNLKFLLRAGETTGGGVVLVTSSIKGEGKTTVSVNTALTLAGKKRVILVGADIRNPQLHRFVDGKNVGLTDYLVSEETSATSYIRSSGLSPNLDVLFSGQIAPNPNDLLDMQKFNDLITTLKAQYDYVVLDSAPVMLVSDTLHLVENADVVLYIVKSGFTEKDMVNFATGFRQENQIKNMAFVLNSVKPENTRYGDKYGYGYYSYTTDEKPKWWKRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F6</accession>
    <name>C6X0F6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781989.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00375"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06842">
        <property type="protein sequence ID" value="ACU06842"/>
        <property type="gene ID" value="FIC_00375"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00375"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_1_10"/>
    <dbReference type="OMA" id="FARQKDH"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="362" mass="41132" checksum="BC2DCC770F520902" modified="2009-09-22" version="1">MKILHIINSLATGGAEKLIVETLPLYHQKGIKADVLLLNGTEYPLYKELAQQNSCRIYSLGKTSVYNPLLIFKIFPFLKSYKIIHVHLFPAQYFAIAAKWLSFSRIPFIFTEHSTFNRRFINNKYKFADQIIYNNYRRIVCITNNVKDAVIKHTSITENKTAVIENGVNLEKITRAQPHPRASLNPQLSDQDFILLQVSSFQHPKDQPTVIRALQYLPDYVKFVLVGDGILRKDCELLVEHVKLQNRVFFLGVRNDVPSLLKNADVIVLSSKYEGLSLSSIEGMASGKPFVASDVPGLAEIVGGAGILFPQGDDAVLAQEILKLMNDRNHYNTVAERCMVRASQYDIHKMVERHIELYRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J2</accession>
    <name>C6X0J2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00411"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06878">
        <property type="protein sequence ID" value="ACU06878"/>
        <property type="gene ID" value="FIC_00411"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00411"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_3_10"/>
    <dbReference type="OMA" id="CLTVMID"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="234" mass="27286" checksum="6EAAFCF28B64002B" modified="2009-09-22" version="1">MPQTIESVLNQSFTDFEWLISDDRSTDHSIEIIKSYADPRIILTVAEKNGGAGYARNLSLAKASGRYITFLDADDWWEPNFLEEMLTFMKSENTELVYSGYARCDGNLHPRIQDFKADKEVNFENLLKTCRLSLLSSIYDSQRVGIEFFPVGSKREDHVMWLNLLKKIRSGKPLPRTLAKYRMHSAGISRRKTNIIKDQYLVYKDYMKFSTLKSLYYTTIWAMNGFMKYSKVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P3</accession>
    <name>C6X0P3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782076.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00467"/>
    <dbReference type="EnsemblBacteria" id="ACU06929">
        <property type="protein sequence ID" value="ACU06929"/>
        <property type="gene ID" value="FIC_00467"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00467"/>
    <dbReference type="eggNOG" id="ENOG50342B1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1783442_0_0_10"/>
    <dbReference type="OMA" id="FRRIQED"/>
    <dbReference type="OrthoDB" id="1494615at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="146" mass="16727" checksum="37EAFF4A3C1E9552" modified="2009-09-22" version="1">MKRLIALCVFLALAACNSQEKYSDFDYSYSRSGGYAPIYENLWIKGDSAHYSLEGEGKKVKKDFKLTAQELKQIDDALARNNFRMIQEDYKKVYDRVSTAIYVKKGPESGRKSDASFIMEADKARWDDVVRVFENIIETKVPTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Q4</accession>
    <name>C6X0Q4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782087.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06940">
        <property type="protein sequence ID" value="ACU06940"/>
        <property type="gene ID" value="FIC_00478"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00478"/>
    <dbReference type="eggNOG" id="ENOG502ZURD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119487_0_0_10"/>
    <dbReference type="OMA" id="YYEIEGF"/>
    <dbReference type="OrthoDB" id="2036055at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="242" mass="26812" checksum="C8200731D8D982EA" modified="2009-09-22" version="1">MKKIFLYIALVSLSVVSCRDDENPNMVEEVSIGTQNSYDDEAAAKYLDTHYLDAKGNIKEFVATDTVNVKLSDLNPVTLPSGVIYVVRPGAQPNPATPIGGTDVISLMGNITTYVASNTDNKVGYYSPFGFKNTIAGAGVPDLDPAYYYVKTSVLTKATAAVAKERSYYEIEGFREALQKFGAYDLPDFENYNLQGVIIVPSRAAFARDPHFNYVGISLRNRSFIFNFQVYKSRARNMQTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S3</accession>
    <name>C6X0S3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CvfB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01590"/>
    <dbReference type="EnsemblBacteria" id="ACU08036">
        <property type="protein sequence ID" value="ACU08036"/>
        <property type="gene ID" value="FIC_01590"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01590"/>
    <dbReference type="eggNOG" id="COG2996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064885_1_0_10"/>
    <dbReference type="OMA" id="GAFMDWG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014464">
        <property type="entry name" value="CvfB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039566">
        <property type="entry name" value="CvfB_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040764">
        <property type="entry name" value="CvfB_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37296">
        <property type="entry name" value="PTHR37296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17783">
        <property type="entry name" value="CvfB_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13509">
        <property type="entry name" value="S1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012524">
        <property type="entry name" value="YitL_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CvfB_WH" evidence="3">
        <location>
            <begin position="220"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="32607" checksum="14AA1746B11F11CB" modified="2009-09-22" version="1">MTLFMNIGHTQLLKIAEKNYSGLFLEDENGERAFLPKIFASEDAQIGEEMEVFVYQDDDKLKATTEKPNAEVGEFAVMACVQSLPSGAFMDWGIIKDLFVPYKQQKQKIIEGRRYLVHVYIDEILGLITGTTTFKRNPQYDDLPLRKGDRVNLIMMGESELGWNVVINKKYIGLIYTSDVYKKLFPLSEEIGYIKSVREDGKIDVSLQPEGYENNDEFQQIILQKLKENYGLLYLSDKSEPEEIKNELQMSKKNFKKAIGGLYRDKKIEILEDKIRLIEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y4</accession>
    <name>C6X0Y4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806382.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01653"/>
    <dbReference type="EnsemblBacteria" id="ACU08097">
        <property type="protein sequence ID" value="ACU08097"/>
        <property type="gene ID" value="FIC_01653"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01653"/>
    <dbReference type="eggNOG" id="COG1256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019817_0_0_10"/>
    <dbReference type="OMA" id="WKEDIGP"/>
    <dbReference type="OrthoDB" id="1230240at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="616"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="687" mass="79739" checksum="00AAAEB616AEB606" modified="2009-09-22" version="1">MITEDSISDQPEKKPVSDVSQENNSGNTSNVEETAPEEITAAEEAEAPTEVLSEEAESENAVEPADSAEQNAAATDTVENEPSETQTLEAHENADLQNIVDSQPEENLVSDVSSESGSGEIQNEEPAEHESVEHLSLNETLNEMQELISKEDAGANFRKFNQLKERANHLIHEQTDAQKTEFTEAGNAAEDFSFHHPEQHRLSALINQFREKNDEYSKKQEANHSKNLEERQNIIERLKTLYTNTEAGTNLFKAIREVKEAWKNAGQVAKSEFKILNNNYFHHLNQFYQMLDMNKEYMEQEYAHNLERRLHIIERAKQLQAEPAVQKALNELQYLHKLWKEEAEPVAEEFREKTWEIFKDISNKIHDRKSELSSQIEGEQVENLEKKNKIIEEIKKLAAPEKEPNHSYWQNSIKKIEDLRSEFLKIGSVPRKVSNQNWNEFKLHLKNFNTAKNEFYKGLKNSQQTNLEKKLQLIQTAKDNSLSEDWETTVPLFKKLQEEWKTIGHVPRSMTNKVWDDFREASNTFFNNFREKNNAVNDNWKENYKQKKQLLEELKEVTDQDGSVEKIENIKTSWNNIGKVPREKLSINTEFNKTLREKMKLNKIHDYNLKEEGLSENQLTDKARKIKNQIADLEAEIVKMETNLGFFSKPTRDNPLLKETFDKIDDKKAQLESMKQSLHSILAGENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y5</accession>
    <name>C6X0Y5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01654"/>
    <dbReference type="EnsemblBacteria" id="ACU08098">
        <property type="protein sequence ID" value="ACU08098"/>
        <property type="gene ID" value="FIC_01654"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01654"/>
    <dbReference type="eggNOG" id="ENOG5032TCF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376370_0_0_10"/>
    <dbReference type="OMA" id="DIVEWNA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="198" mass="22993" checksum="C070F19CE8DB94D6" modified="2009-09-22" version="1">MFRNLLFALLFCTLTGVKAQDGVRDLLSVPGPIEFNGTDFLLAWSKESSKTLMRQQYMPRDERIEDFNQILDFSFFTKEIDMELAVRQKVESIQKREEKDRFAKVNVTESPDGKEFVVDYFISENPNGGDAFVEYNIYRFKPYENTTGKNFLILAYTTRMYGDTKSAAKALAKQRDALMLAMIEYKIPEIKVNRDITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X146</accession>
    <name>C6X146_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806444.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01716"/>
    <dbReference type="EnsemblBacteria" id="ACU08159">
        <property type="protein sequence ID" value="ACU08159"/>
        <property type="gene ID" value="FIC_01716"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01716"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_10"/>
    <dbReference type="OMA" id="DIMMPML"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="123" mass="13789" checksum="71986C8308E4B4E7" modified="2009-09-22" version="1">MIKENKKVFIFDDNVEILELCTEILNDIGCEVKTSPTTTDVEEQVAEFMPDLILMDNWLPDISGVEATKLIKANDDLKHIPVIYFSANSNIGELASLAGAESYLAKPFDIDQFEQMILKYADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X195</accession>
    <name>C6X195_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806493.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01765"/>
    <dbReference type="EnsemblBacteria" id="ACU08208">
        <property type="protein sequence ID" value="ACU08208"/>
        <property type="gene ID" value="FIC_01765"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01765"/>
    <dbReference type="eggNOG" id="ENOG502ZBUC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087837_0_0_10"/>
    <dbReference type="OMA" id="FVEFHFT"/>
    <dbReference type="OrthoDB" id="1710497at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="214" mass="24788" checksum="E56496328AAECA5B" modified="2009-09-22" version="1">MMKIISAVLLLTVASCSNEKSSVGPTAADSVRPEENQNEKAIPKPAKLTKQDSLRNISKDVLNTLKLKDYQRFATFIHPQKGVRFSMYGFVRTETDKHFSRAEFLNYINTPTRFTWGEKDGSGDQYVISLKDYFENWVFKRDYTQSDIYLNEFKGTGNSLNNLQQIYPNADFTENYIAGSEKYAFMDWNALRLVFEKFEGKYFLIAVVNDQWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A9</accession>
    <name>C6X1A9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PAS/PAC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806507.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01779"/>
    <dbReference type="EnsemblBacteria" id="ACU08222">
        <property type="protein sequence ID" value="ACU08222"/>
        <property type="gene ID" value="FIC_01779"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01779"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002188_1_0_10"/>
    <dbReference type="OMA" id="AMNGDIN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="284"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="677"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="916"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="1205"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="966"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="1110"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="4">
        <location>
            <position position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1298" mass="146452" checksum="EB7A55A9101F0B34" modified="2009-09-22" version="1">MNKFPVPENEEARLQKLAYYDLINLARDSDLDLFSEAACLISGCPASLIAMMERDTQTIQSCIGLELDFVDRRDTVCQYTVQSGQVVIINDTLEDERSSANPLIIAGGIRFYAGFPLLDAEGFVLGTLCVIDYKPRTLSDEQIAALSKLAEAVSRQLMAKRKAAHAEYYEQLFTVTNNLICVLDNNFNVKTVNTAFENTYGTSSEALGKNFREILSRGGNPVSLSEDHLMDAGEYFFTSRLNSGSGETMVIEWLIKRNHNRTEIFCFGRNVTRLIAEKQKLERSERRFRSFFENAIGLMSMHDMEGNILAVNEKGRETLKYSAEETQKLNLRDLVPKDNWQLLQGYLERIAEYKEDSGYMMLCAKDGEQLVWMYHNLVEIDENGRPYVVSTALNVTEKMSLEKDLIYTKKILEQTSAAARVGGWEVNLQNGKTFWSQTTKEIHKVADDFEPELASALDFYTEESRERVSALFDRAVKTGERYDDEFELSQPDGSRIWVRAIGIPEFEHGVCKKVFGIIQNIDIAKRTYLELEKKEAMLQSFVKDVPVAVAMFDHNLNYLSVSKWWTDEFSMDVNAMKGRNIFEVSPNVPEERVKMYMGALQGKSYKSENLVLPVPGKTQVQHYNMEVSPWFLANKVIGGVIVSVQNITERVRTTVELKNAQQLAVRASKAKSEFLANMSHEIRTPLNGVIGFSDLLLKTPLNEMQTQYLNYINESGESLLTIINDILDFSKIESGKMELMIDRTPVYDMVGQVINVILFQSQKKDLELLLNIEPGLPEILFLDESRVKQILINLLGNAVKFTLRGEIELKVQKLRMDAERIALRFAVRDTGIGIPKDKQKRIFDAFTQEDSSVSKKYGGTGLGLTISNNILKYMGTSLSLKSTPGEGSEFYFDIEVPYEEVIAGEEEDIADLGIKSVLIVDDNENNRIILQHMLAYKNIDSRLAANGMEALQILMAGERFDIILMDYHMPVISGLETVTKIRELYTEHDEVSPLVVLHTSSEEHEVINSFRQSENSYCLLKPIKSRDLYATLKQAVRQTEKKPTDVTTQEKEAALSGLKVLLVDDNPVNMVLNNRMMQSLVQDAVFAEVTDGKQALDLCRNQVFDLILMDVQMPVMDGIEATKQIRELPHAKPVIIGVTAGNVVGEKEKCLDAGMDDFLTKPLRQAELLIALQNNIYGKNDDRGSNGDAELYLDMNHLEQQVGDDEEFRNMFLNLVVQETEASGLALKEACRQDDRGEIKKILHKLKGTAGTAGLFSLAETAAKWENRIDRSPDLTSLEKEIAAGIATGLELIKKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D8</accession>
    <name>C6X1D8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806536.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01808"/>
    <dbReference type="EnsemblBacteria" id="ACU08251">
        <property type="protein sequence ID" value="ACU08251"/>
        <property type="gene ID" value="FIC_01808"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01808"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091428_1_0_10"/>
    <dbReference type="OMA" id="AKAWWDS"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrid_ox_like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="18844" checksum="777A5B248AB08B0F" modified="2009-09-22" version="1">MSTENLNNTEALKKLKELSESARICMFCTDLTSLPITVRPMSLQETDTEGNLWFISSDASNKNFQIAEDNRVQLLFMNNSNSEYLSVFGNAYIYKDKATIEDKWSNLASAWFEDGKDDPNVSIIRVAPEDTYYWDTKAGKLVSLISFAAAAISGTKTDNSDGVEGKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H9</accession>
    <name>C6X1H9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806577.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01849"/>
    <dbReference type="EnsemblBacteria" id="ACU08292">
        <property type="protein sequence ID" value="ACU08292"/>
        <property type="gene ID" value="FIC_01849"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01849"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125425_0_0_10"/>
    <dbReference type="OMA" id="WNIAHTV"/>
    <dbReference type="OrthoDB" id="1717097at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="156" mass="18233" checksum="3E952AACB2FA54A4" modified="2009-09-22" version="1">MNYHFQAHRQVRKNLLDILQNTSPKDLMLIPDGFNNNIYWNIAHTVATQQLLCYYLSGNPFRIDKYWIETYKKGTLPNLNVEQSEVDDLAFLLTETSKILMKDYDADFFADYTPYTTSFGLDLKNIQDAIIFNNMHESLHFGYAMAQKRALIGETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1N3</accession>
    <name>C6X1N3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bleomycin resistance protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806631.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01904"/>
    <dbReference type="EnsemblBacteria" id="ACU08346">
        <property type="protein sequence ID" value="ACU08346"/>
        <property type="gene ID" value="FIC_01904"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01904"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_15_4_10"/>
    <dbReference type="OMA" id="KPWGQKE"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08349">
        <property type="entry name" value="BLMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000335">
        <property type="entry name" value="Bleomycin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="118" mass="13680" checksum="EAF515AC9900D9E8" modified="2009-09-22" version="1">MLTNIHPKLPMRSKEATTKYYVGLLGFKETDNQDFDGYLMLKKDGIEIHFFQFKELVPSENYGQVYIRTDDIESLYQTFLDRGVSIHPNGPLQIKPWGQKEFSLLDPDNNLLTFGQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P2</accession>
    <name>C6X1P2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
                <ecNumber evidence="16">4.2.1.59</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="16">Beta-hydroxyacyl-ACP dehydratase</fullName>
                <shortName evidence="16">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
                <shortName evidence="15">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
                <ecNumber evidence="15">3.5.1.108</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">lpxC</name>
        <name evidence="16" type="synonym">fabZ</name>
        <name evidence="17" type="ordered locus">FIC_01913</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="14 16">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the LpxC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="16"/>
    <dbReference type="EC" id="3.5.1.108" evidence="15"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01913"/>
    <dbReference type="EnsemblBacteria" id="ACU08355">
        <property type="protein sequence ID" value="ACU08355"/>
        <property type="gene ID" value="FIC_01913"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01913"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046528_2_0_10"/>
    <dbReference type="OMA" id="RRGICHM"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU08355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="474" mass="52618" checksum="396FBEA55EC6F683" modified="2009-09-22" version="1">MRTLQKIIAVSDKQKTLKEEISLCGIGLHTGRQVTLTIKPAKENTGFVFVRTDLEGQPHVEADVNYVTTTERGTTLEKLGVRIHTCEHLLAALVGCDIDNAFLEMDSAEPPILDGSSKFFVEAIEKAGIEEQNLYREYLVVKEVLSYTDPTTGSDITIIPSETYEVTTMVDFGTKVLGTQNATLKDISEFKDEISSARTFSFLHELEMLLDAGLIKGGDISNAIVYVDKELTPETSDKLKKAFGKDNVSIRPNGILDNLTLNYPNEAARHKLLDVIGDLALVGVKIKGKVIANKPGHFVNTQFAKKLNRQWKLQKKKNVPDIDITKEPVFDINGIMRLMPHRPPFLLIDKILELSDSHVVGLKNVTMNEPYFVGHFPKEPVMPGVLQVEALAQTGGILVLASVPDPENYSTYFIKIDKVKFKKKVVPGDTMVFKIELISPIRRGIVHMQGYGYVGDSIVVEAELMAQVAKNKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W1</accession>
    <name>C6X1W1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNase-like nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806709.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01982"/>
    <dbReference type="EnsemblBacteria" id="ACU08424">
        <property type="protein sequence ID" value="ACU08424"/>
        <property type="gene ID" value="FIC_01982"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01982"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_7_0_10"/>
    <dbReference type="OMA" id="SACSREK"/>
    <dbReference type="OrthoDB" id="1719840at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01123">
        <property type="entry name" value="TNASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970550" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="161" mass="18632" checksum="FFB42EE122A99A5A" modified="2009-09-22" version="1">MKKFLILWCVVLFSGVMLSQTITAKVVGVKDGDTMVMLFEDRQFVVRLAHVDTPEKKQPFGNNAKQFASDFCFGKNVKVVSVGKRDRNGRWIAEIFYKNQNLGKELVRNGLAWHYKAYSKSENYAQLEKRARMSRKGLWQDPKPVAPWNFRKSRKKAAKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y0</accession>
    <name>C6X1Y0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ordered locus">FIC_02001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806727.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02001"/>
    <dbReference type="EnsemblBacteria" id="ACU08443">
        <property type="protein sequence ID" value="ACU08443"/>
        <property type="gene ID" value="FIC_02001"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02001"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_0_10"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="461" mass="50594" checksum="05D9969E3CB0C5DA" modified="2009-09-22" version="1">MKEFIQTLKNIWSLKELREKILFTLGLVLVYRFASYISLPAINMAEVGNLLDHYQNQGGNKQGAGLLGLLSSFTGGAFSRASIMALGIMPYISASIIVQLMGMAIPYLQKLQKDGESGRNTLNQITRWLTIAVCLVQAPSYLTSITQMFLPHAQFASAYYVHPESVMFWLPSIVILVAGSVFAMWLGEKITDKGIGNGISILIMVGILADLPGAFIQEVATQTGKGGLGTIMILIEVLFWMLVVLLAIVLSVAVRKIPIQYVSRAQARGGANRNLMQGARQWIPLKVNASGVMPIIFAQALMFVPGLLTKVDESNTFLAGFKDVFSWQYNVLFAVLIIIFSFFYTAITIPVNQMADDLKRNGGLIPKVRPGKETADYLDDILSKITLPGSIFLAIFAVLPAIVHGAFVQTDRFALFFGGTSLLIMVGVILDTVQQINTYLLNHHYDGLMQSKLSRTTNPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z3</accession>
    <name>C6X1Z3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="9" type="ordered locus">FIC_02014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806740.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02014"/>
    <dbReference type="EnsemblBacteria" id="ACU08456">
        <property type="protein sequence ID" value="ACU08456"/>
        <property type="gene ID" value="FIC_02014"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02014"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_10"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="141" mass="15887" checksum="6E33BBD85F57FC47" modified="2009-09-22" version="1">MLQPRRTKFRKVHKMKMKGVAQRGNQLAYGTFGIKATEGAWITARQIEAARIAATRYMKREGQLWIKIFPDKPITKKPAEVRMGKGKGAVEYWVSVVKPGKIMFEVGGVPYEVAKEALRLAAQKLPVVTKFVVANDFVQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z8</accession>
    <name>C6X1Z8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplW</name>
        <name evidence="6" type="ordered locus">FIC_02019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806745.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02019"/>
    <dbReference type="EnsemblBacteria" id="ACU08461">
        <property type="protein sequence ID" value="ACU08461"/>
        <property type="gene ID" value="FIC_02019"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02019"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_0_10"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="10600" checksum="4A086ABD76CBEF8E" modified="2009-09-22" version="1">MSIIIKPIISEKANYLTDLRGAYSFFVNTKANKIQIRKAVEEAYGVKVADVRTMIYAPKVSSKHTKKGLQVGKTNKLKKAVVSLAEGEVIDIFATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X241</accession>
    <name>C6X241_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806788.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02062"/>
    <dbReference type="EnsemblBacteria" id="ACU08504">
        <property type="protein sequence ID" value="ACU08504"/>
        <property type="gene ID" value="FIC_02062"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02062"/>
    <dbReference type="HOGENOM" id="CLU_1616566_0_0_10"/>
    <dbReference type="OrthoDB" id="1892729at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="164" mass="17561" checksum="21C1D194DC91EAA3" modified="2009-09-22" version="1">MKNTIIGFLSVVVFTVISCKKDHETVKSDVSAAHGGSSALSDSTNIDTVAPSDAAVFKINAQDISSQKGRTVFTQNGSTLFYFDIDANKGVVRIDGVEYELNRADFNENNYSLSGDGVTIHATNGDFGEMVNDCVAGTFPEVKISHDGKTLKLAQVAVQDCPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X247</accession>
    <name>C6X247_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase (NAD)</fullName>
            <ecNumber evidence="4">1.2.1.16</ecNumber>
            <ecNumber evidence="4">1.2.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.16" evidence="4"/>
    <dbReference type="EC" id="1.2.1.24" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806794.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02073"/>
    <dbReference type="EnsemblBacteria" id="ACU08510">
        <property type="protein sequence ID" value="ACU08510"/>
        <property type="gene ID" value="FIC_02073"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02073"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_10"/>
    <dbReference type="OMA" id="KAMRWYA"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="7"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="428" mass="47056" checksum="B353BA6347709999" modified="2009-09-22" version="1">MATQNKLEIADSAFKKWKSVNFKTKQTLLKKLADLLDKNAEKYGQNITKEMNKPISQSIAEIEKCALMTRYYAEAENVLQPEKISTEFRISEVHYVPMGVILGVMPWNFPFWQVLRFAVPAVLAGNTVVLKHASICFGSGKLMEKLFLDAGFPKGIFQNLEIGHAEVKSVLENPVIKGVSLTGSEKAGAEVASIAGKNIKKSLLELGGSDAFIVLDDSNLKKAAKSGAKARLANCGQACNAGKRFIIQKNVEKEFLPLFISEYQKYVPGDPMDKSTKLTGMARPDLADELEKQYKKAQKHGAKIILPLKRVSDYEFEPGLIKVKKGNPILQEELFGPLGIVMSAKDDSEALELANDIPFGLGNSVWTKNRKRQKFFSENLESGTVSINKETSSDPRLPFGGAKSSGYGTELSLIALKEFVTAKTIVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X261</accession>
    <name>C6X261_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806808.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02087"/>
    <dbReference type="EnsemblBacteria" id="ACU08524">
        <property type="protein sequence ID" value="ACU08524"/>
        <property type="gene ID" value="FIC_02087"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02087"/>
    <dbReference type="eggNOG" id="ENOG503304V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203068_0_0_10"/>
    <dbReference type="OMA" id="RHCPYGY"/>
    <dbReference type="OrthoDB" id="1980284at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040807">
        <property type="entry name" value="DUF5522"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17653">
        <property type="entry name" value="DUF5522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="59" mass="7067" checksum="4F0EA54C99DBA41C" modified="2009-09-22" version="1">MSANGIKENEDFYYNEQGYKVFTEKYHLKRGYCCKSGCKHCPYGYDKKTDRFIKPIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X264</accession>
    <name>C6X264_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806811.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02090"/>
    <dbReference type="EnsemblBacteria" id="ACU08527">
        <property type="protein sequence ID" value="ACU08527"/>
        <property type="gene ID" value="FIC_02090"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02090"/>
    <dbReference type="eggNOG" id="ENOG502ZTWR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124910_0_0_10"/>
    <dbReference type="OMA" id="WGIDADP"/>
    <dbReference type="OrthoDB" id="1441272at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="19865" checksum="0F1ED8479539A73E" modified="2009-09-22" version="1">MLTDQTKPSDFKKSERADYSHIKGWGIDADPQNDPSYPMKKRTNEEHEGYAWDRPEQQSDDVEILKSVERPNLTSVFGSASPPEGLNGHLRRLAFKYSESSYGRWLPLVLADRVGEVEGIIDDLKKGHVPNFFAEHGWGAEWKYNKKGFLLKIAAVAAVSAVAITLLSSKKDSDNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C3</accession>
    <name>C6X2C3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806870.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02150"/>
    <dbReference type="EnsemblBacteria" id="ACU08586">
        <property type="protein sequence ID" value="ACU08586"/>
        <property type="gene ID" value="FIC_02150"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02150"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_10"/>
    <dbReference type="OMA" id="RHIIARR"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="414" mass="45174" checksum="492ECCFFB7A02774" modified="2009-09-22" version="1">MQTINRTSQSYIELEEKHGAHNYHPLPVVLERGEGVFVWDVEGKKYYDFLSAYSAVNQGHSHPKIVDAMINQAQKLALTSRAFHSSNLGEYEKKITLLFGFDKVLPMNSGAEAVETAVKLARKWSYEVKGIAENSAKIIVCENNFHGRTTTIVSFSNDPDANRNYGPFTPGFVKIPYNDLSALEEALENDAENIAGFLVEPIQGEAGVYVPDEGYLKSALKLCQKYNVLFIADEVQTGIARTGKLIACHHEGVQPDILILGKALSGGMYPVSAVLANDSIMNVIQPGQHGSTFGGNPLACAVATAALDVVADENLSEKAEKMGQLFRSEIEKIIASTDLVNGVRGKGLLNAILINDTPESKTAWNLCLALKENGLLAKPTHGNIIRLAPPLVITEEQIHDCVAIIEKTVLEFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D5</accession>
    <name>C6X2D5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tsf</name>
        <name evidence="9" type="ordered locus">FIC_02162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806882.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02162"/>
    <dbReference type="EnsemblBacteria" id="ACU08598">
        <property type="protein sequence ID" value="ACU08598"/>
        <property type="gene ID" value="FIC_02162"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02162"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_0_0_10"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="8">
        <location>
            <begin position="73"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="273" mass="29331" checksum="C10BDA45DB8F7C13" modified="2009-09-22" version="1">MYTPVAADVAKLRNITGAGMMDCKKALVEAEGDFDKAIENLRKKGQKVAANRADRESTEGAVIAKVSADKTKGTIIALNCETDFVAKNEDFVKLAHELAELAVGKTKEEFLAAEYSGTTVAEKLIDQTGIIGEKIEIGSFETIEGPYLGAYIHAGNKIAAITSLSADVAGGDEVAKSVSMQVAAMNPIALDETKVSQETIDRELDIEREILTKEGKPANIIDNILKGKMQKFYKDNTLVHQSFIKDSGLSVAEYVKSVNADLTVVGFVRVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H0</accession>
    <name>C6X2H0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02198"/>
    <dbReference type="EnsemblBacteria" id="ACU08633">
        <property type="protein sequence ID" value="ACU08633"/>
        <property type="gene ID" value="FIC_02198"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02198"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087886_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972244" evidence="1">
        <location>
            <begin position="28"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="270" mass="29674" checksum="0C4D1ADF58900C2C" modified="2009-09-22" version="1">MSFCNSMNKFFRYLPVFLLFPFGTALAQTGLSVSPPRTYVTSAAWQSSINKILVTNTSKDVSLNLTVSLSDWQYDEQGNNVVADAGTLVNSATPWITIKPQSYFTLAPGETHELEVTVVAPAQKDSVDVHTSLLFITQTNPVDSFEQGALVKVSLRSGVKIYHRYNSSANASIEFNNYLLDKKSGSLQLALENTGNIWTDGTVITELVNVNDGTKYELEDQIIYTLPGDKRNVSVPLPADLKPGKYTASSTLSYGDDDTIKMAELAFVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H1</accession>
    <name>C6X2H1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806918.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02199"/>
    <dbReference type="EnsemblBacteria" id="ACU08634">
        <property type="protein sequence ID" value="ACU08634"/>
        <property type="gene ID" value="FIC_02199"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02199"/>
    <dbReference type="eggNOG" id="ENOG502ZMB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129762_0_0_10"/>
    <dbReference type="OMA" id="NLHVVIN"/>
    <dbReference type="OrthoDB" id="1517289at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970560" evidence="1">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="19418" checksum="DD6195E0E305F6AD" modified="2009-09-22" version="1">MKKGILFIGLLGGLFAANAQTASTYTNAGPATGNVTLNVNLYPLQSITVNPSSSVVNLDYKTSADYLGGVNKTEANHLTVFSTGAFDVKVKSNAASLTGPTGTTAIPLKDIQILATQGSTNPLTGFTPLTAVTLTQNDQIIGGSDTFGSGNINVNYKAAGNNEYLSRVVKGTTPTTYTASLTYSIIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H3</accession>
    <name>C6X2H3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YCE I like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02201"/>
    <dbReference type="EnsemblBacteria" id="ACU08636">
        <property type="protein sequence ID" value="ACU08636"/>
        <property type="gene ID" value="FIC_02201"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02201"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_2_0_10"/>
    <dbReference type="OMA" id="EGSPENW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="83"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="266" mass="28584" checksum="06F31053CA9A277E" modified="2009-09-22" version="1">MHLIIIFKLKSTHLLRFLILCQFGLRSGTRTFASHLNKQLSKMKNLSIFALSVFMLAASCKESKTDSATVSTEQAVAETAGETFSVNSDSSTVNWTAYHKGGLNPRFGTTKASGTFSVENGNIVSGSLVSDINSLTTDPKAVDPSINDGKTSADLDGHLKSADFFDVAKYPSVKFDITKVEDLAAGTASKVEGANKTVSGNLTIKDKTVNVSFPAKVEVTEGKVNVTSKFTINRQDWGLAYGTEGDPKDWMISQDVDLDLNIVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H5</accession>
    <name>C6X2H5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806922.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02203"/>
    <dbReference type="EnsemblBacteria" id="ACU08638">
        <property type="protein sequence ID" value="ACU08638"/>
        <property type="gene ID" value="FIC_02203"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02203"/>
    <dbReference type="eggNOG" id="COG4277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033784_0_0_10"/>
    <dbReference type="OMA" id="GYIHLKA"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF9">
        <property type="entry name" value="PTHR21180:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01102">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03916">
        <property type="entry name" value="rSAM_link_UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="50"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="418" mass="48031" checksum="90D926FA1A6DB83F" modified="2009-09-22" version="1">MNFERIQEKLEILADAAKYDVSCSSSGGTRKNKGGLGNSHASGICHTYTEDGRCVSLLKILLTNHCIYDCAYCVSRKTNDVKRAAFTVEEVVELSINFYRRNYIEGLFLSSGIFKDSDTTMERLVRVAKKLRLEHNFNGYIHLKSIPGASDELMKEAGLYADRLSINIEIPTEKGLKLLAPDKSHSEMIKPMTLVKNELILYKEEKKIFRKVPKFSPAGQSTQMIVGATNETDLKIIKVADHFYQNFNLKRVYYSGYVPVLEDSRLPSIHSQVPIQRENRLYQADWLMRFYGFEANEILDPTNPFLDLEIDPKLAWALRNREQFPVNINTATKEMILRVPGIGTKSTDKILMARRFQKLNLENLKKMGVAINRAKYFVEFESTNVFNRLIDEQNFRKIILSGMKSKYQNPFSEQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K4</accession>
    <name>C6X2K4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B12 binding domain / kinase domain / Methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="2">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02232"/>
    <dbReference type="EnsemblBacteria" id="ACU08667">
        <property type="protein sequence ID" value="ACU08667"/>
        <property type="gene ID" value="FIC_02232"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02232"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105857_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="251" mass="27664" checksum="911C1F82DA883519" modified="2009-09-22" version="1">METQKYSPKNKIRIVTAAALFDGHDAAINIMRRVIQATGVEVIHLGHDKSAEEVVNCAVQEDANAIALTSYQGGHNEYFKYIYDLLKEKNASHIKIFGGGGGVILPEEIKDLMDYGITRIYSPDDGRELGLQGMIDDLVQKSDFATGEHVQVADLDNIKFEESKSLAEVISAVENFSDEKPELVKEIEERAKDSTIPIIGITGTGGAGKSSLTDELVRRFLRSNPEKKIAIISIDPSKKKPEVRFWATESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K7</accession>
    <name>C6X2K7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LptD_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02237"/>
    <dbReference type="EnsemblBacteria" id="ACU08670">
        <property type="protein sequence ID" value="ACU08670"/>
        <property type="gene ID" value="FIC_02237"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02237"/>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007637_0_0_10"/>
    <dbReference type="OMA" id="GRYTTCD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045659">
        <property type="entry name" value="LptD_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19838">
        <property type="entry name" value="LptD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LptD_2" evidence="1">
        <location>
            <begin position="209"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="863" mass="98218" checksum="2DAD64097F8B974A" modified="2009-09-22" version="1">MVKTGSKNILLILIILIFNNFLALAHAQNLSENKAVNDTIIRTDTLTGANEQLEAVVETRADNIRNDVPKKMTYLNKKAQVKYQDMEIDADYISIDWNKSLIFARGELDSLGRIKTPAVANQGGKKYEYDEFTYNIKTRQAIAFNARTEESEGVIIAERTKKYNDSVFFMRRGKYTTDEYFIQKKDTIADYYLLAPNIKLIKGKDKSQVITGPIQLYIEQVPTPLIMPFAILPFSDKRSAGILIPSFGEREDVGFFLNSIGYYQPIGDHFDLKILADLYTKGSWNLRPEVNYKKNYRYTGNFSADIGTTVRGIKGLSDYSKTGTYRIAWRHQQDTKANPFLTFSASVDVVSNRFYNNTVNNNYAFNQNNLNAQQNSSISVVKRFLTLPVTITGTSSYSQNFSTGLADIKLPVLNVAINQFYLFNPKSGIRQGLLENITVNTGLNFNNYVQTNEDELFTGAMWDKMQTGLKNNITLGTNTTIAKYFTFSINANIDNALTTKILTRTYNPITNKVDDVLNKKIAGYSSFSTGASLQTVLYGMLNFKRSSAVQAIRHMMTPQIGFSYSPDFSAPGFGYYKNYANDRGEMTPYSIFDRGIVGSPNASLVQALSLSVNNNLEMKVRSKKDSTGVKKIKIFESLNFNTNYNFAAPKYKWSIFSLNGQTTLFEKLNLNTGLNLEPYRITFEPGENVGIRTEDFGHFSVQGFNAQLSYPLSSEIFKKKDEEDISKKYNKKGEIRNENYYFDEDNYSQFTQPWTLNINAQYSYTRSLTRFGNKMASIGLDGSIKLTPYWNITGNLYYDVISKEIANTQLGFSRDQRSFTINFNWIPYGQYKVYDFFIGIKANILRDALKYKDRSFTQPNAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N1</accession>
    <name>C6X2N1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amino acid ester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806978.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02261"/>
    <dbReference type="EnsemblBacteria" id="ACU08694">
        <property type="protein sequence ID" value="ACU08694"/>
        <property type="gene ID" value="FIC_02261"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02261"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_5_0_10"/>
    <dbReference type="OMA" id="FFFDDFH"/>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668859" evidence="1">
        <location>
            <begin position="19"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="358"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="618" mass="70863" checksum="F3DDAE5619F5095F" modified="2009-09-22" version="1">MKKLLQFALLFCFLSVAAQTRPDNTFVKEKFTKQEVYIPMRDGVKLFTAIYIPKDISKAQKYPFIMQRTCYSIAPYGENEYRASLGPNKFLMNDKYIFVYQDVRGRYMSEGTFTNMTPQVERKTKKDVDESTDTYDTIEWLLKNIKNNNGKVGQYGTSYPGFYTAAGILADHPALVASSPQAPISDFWNDDFLHNGKFMLGYFRTFPVFGVQKTKAENKAWYSDSMIKSTSEDGLKFYREMGTLKDGYDKYYKDNFFMTEIMNHPNYDELWQKRSLLPHLKNVKHAVMTVGGWYDAEDLSGPLNIYKTIEKTSPKAKNTIVMGPFSHGAWGRETGKHFHNEIYFGDSIATYYQKNLETKFFSHYLKGNTKADAGLPEAAMYDTGKKEWKEFDLYPPKNTAKINFYLADGTLKQAAGNTASEYFSDPNNPVLSSDNLKDFNGFTPRNYMSEDQRFAVGRPDVITFTTNVLTEDLTFAGEILAKLNISSTSTDADFAVKLIDVYPEDFKPTEKKEGVVYGNYHQMVRSEIMPARFRNSREKPEALVPNQKTAVNFRLQDVVHTFKKGHKIQIQISSTWFPLFSVNPQKFMANPNLATKEDYTKAFIKVFGDSSIEVDVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W2</accession>
    <name>C6X2W2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02342"/>
    <dbReference type="EnsemblBacteria" id="ACU08775">
        <property type="protein sequence ID" value="ACU08775"/>
        <property type="gene ID" value="FIC_02342"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02342"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_11_1_10"/>
    <dbReference type="OMA" id="TGPMSVT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="36"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="555" mass="59418" checksum="8051D23B928449CD" modified="2009-09-22" version="1">MIKIIFQHCNLLLRSILRYTTFSKMKKAKSIYGGIKENFPSGLVVFLVALPLCLGIALASGAPPLSGIIAGIIGGLVVGYLSNSNISVSGPAAGLTAIVLTAITDLGAFELFLCAGLIAGLLQLILGFVRAGSISNYFPTNVIEGMLAGIGIIIILTQIPNAFGFTNGFETKETLFENGFNPAYFGQLASGVHMGAVIVTLVSVSILLAWDKFPVLKKIKMIPGALVAVAAGILLNYIFVVSGSSLAIGPEHLVSLPVPQTAADFTNMLVFPDLNGFLNPKVWIVGATIAIVASIETLLCIEASDRLDTHRRITDTNLELRAQGIGNLLSAAIGGLPMTSVVVRSSANASAGATSKTSTMIHGVLLLVCVLTIPFILNLIPLATLAAVLILVGYKLAKPATIMHFWHKGKYQFIPFIATVIAVVSLDLLKGVGIGLLISVFYILQGNMKRAYYLSREDLDDADDINIKLAEEVSFLNKAAIKKTLKNVRPNSKVCIDARSTSYIATDILDMIQEFANIRAKEEDIEVTLLGFKTSYREYAEDEDSHVIIAHRRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W3</accession>
    <name>C6X2W3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807060.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02343"/>
    <dbReference type="EnsemblBacteria" id="ACU08776">
        <property type="protein sequence ID" value="ACU08776"/>
        <property type="gene ID" value="FIC_02343"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02343"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_4_1_10"/>
    <dbReference type="OMA" id="LPAHIQY"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="211" mass="23192" checksum="4435072673A28AAC" modified="2009-09-22" version="1">MKAHTLETQTTTTPDKALKFLQEGNQRFVQNLKMNRNLLEQVNDTRAGQWPFAVVLSCIDSRTSAELIFDQGLGDIFSIRIAGNFVNKDILGSMEFGCNVAGSKLVVVLGHSKCGALKGGLDARSIEPAGMENLNHLISNFEGCINEILREGEERSSSNSDLLERLNVCNIKRTISDIRSQSSTLRKLEEEGSIKIVGANYCVESGVVSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X365</accession>
    <name>C6X365_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="7" type="ordered locus">FIC_02445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807162.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02445"/>
    <dbReference type="EnsemblBacteria" id="ACU08878">
        <property type="protein sequence ID" value="ACU08878"/>
        <property type="gene ID" value="FIC_02445"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02445"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_1_2_10"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="140" mass="15149" checksum="81B9E6FB84819318" modified="2009-09-22" version="1">MFAIVEIAGLQYKVEQDQKLFVNRLKGDIGAKVSFDKILLTVNGATTIGAPAVSGIVVDAEILDHVKADKVIIFKKKRRKGYEKKNGHRQSLTQIVITGITGFDNNKKEKKAAPKAKKAAPATEEAPAANETTTNSETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X397</accession>
    <name>C6X397_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engB</name>
        <name evidence="10" type="ordered locus">FIC_02477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807194.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02477"/>
    <dbReference type="EnsemblBacteria" id="ACU08910">
        <property type="protein sequence ID" value="ACU08910"/>
        <property type="gene ID" value="FIC_02477"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02477"/>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_1_10"/>
    <dbReference type="OMA" id="LMMDIRH"/>
    <dbReference type="OrthoDB" id="1746051at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="206" mass="23684" checksum="4FA26F0AD4EB035D" modified="2009-09-22" version="1">MVIKTAEFVTSSARWQDCPEPTMPEYAFIGRSNVGKSSLINAMLNFKDLAKTSQTPGKTQLINHFVINEQWFLTDLPGYGYARVSKTKRKEFEKLITNYILNRKNLVNLFVLVDARHTPQKIDIEFIEWCGENSVPFSIVFTKADKLKPNTVISNVEHYKTELLKTWEDLPEIFVTSAEKRDGTDEVLKLISKTNTFLIENKINFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I6</accession>
    <name>C6X3I6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP reductase</fullName>
            <ecNumber evidence="4">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="4">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">guaC</name>
        <name evidence="9" type="ordered locus">FIC_02569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4 7">
            <text>IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807283.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02569"/>
    <dbReference type="EnsemblBacteria" id="ACU08999">
        <property type="protein sequence ID" value="ACU08999"/>
        <property type="gene ID" value="FIC_02569"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02569"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_5_3_10"/>
    <dbReference type="OMA" id="AYKEYFG"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="8">
        <location>
            <begin position="9"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="4 5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="346" mass="37568" checksum="20066FAE4186C283" modified="2009-09-22" version="1">MRIEYEIKLGFKDVMIRPKRSTLKSRSQVSLDRTFTFRNSQKKWTGVPIIAANMDTVGTFEMAEALAKEKVVTAIHKHYTAEDWAHFLSTQPDSIYDYIALSTGTGSEDEAKIKQIVDQHPKIEFLCIDVANGYSEHFVEFVKKIRASFPTKTIIAGNVVTGEMVEELILAGADIIKVGIGPGSVCTTRIKTGVGYPQLSAIIDCADAAHGLGGHIISDGGCKIPGDVAKAFGGGADFVMLGGMFAGHDESGGDIVEENGKKYRLFYGMSSQTAMDKHAGGVAEYRASEGKTVKVQYKGAVAETLKDILGGLRSTCTYVGASELRELSKRTTFIRVLEQENQVFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I7</accession>
    <name>C6X3I7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807284.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02570"/>
    <dbReference type="EnsemblBacteria" id="ACU09000">
        <property type="protein sequence ID" value="ACU09000"/>
        <property type="gene ID" value="FIC_02570"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02570"/>
    <dbReference type="HOGENOM" id="CLU_2600900_0_0_10"/>
    <dbReference type="OrthoDB" id="1581071at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU09000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="79" mass="9450" checksum="456DC3169AEC7940" modified="2009-09-22" version="1">MKKFLILLLVVFFGLFHAQKKLPSERLLDEIQQMRQNENNLKIVWWIPADYWELAIKENGQATPEEIAYLKSILEKYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J5</accession>
    <name>C6X3J5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807292.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02578"/>
    <dbReference type="EnsemblBacteria" id="ACU09008">
        <property type="protein sequence ID" value="ACU09008"/>
        <property type="gene ID" value="FIC_02578"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02578"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014750_2_0_10"/>
    <dbReference type="OMA" id="YMFQYND"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043864">
        <property type="entry name" value="Omp85-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19143">
        <property type="entry name" value="Omp85_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973422" evidence="3">
        <location>
            <begin position="20"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="35"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU09008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="721" mass="80286" checksum="470249C43D6EE795" modified="2009-09-22" version="1">MKKLHAFFLVLLLNFTLHAQVKQGLVIPKNPKVGLSLSGGGAKGFAHIGVLKVLDSLGIKVDYISGTSMGAIVGGLYASGYTGKEIEKIVLNTDFYNIIANEKTREESTFFNKSVDKYILTIPVKDGKVNVLPKAISTGQKNIYLLKELFKNVSTITDFSKLPIPFMCVATNLESGKTEVFEKGDLVSAIMASSAFPSLMDPVKINDSLYIDGAMTINYPSKPLKDKGIHIVIGVDLSQGLANRDNLGSAIAILNQVIDFGIQKETVNQYQYTDINIRPDLTGMTSTSYGSTKSILDSGYAEATKYVEPLSLLPKRKQELLRAPMNSLYSNVYKIDSLILENNHIFSENYVSGKMHLRLPALLTYGGVNKMVDRLYSTNNYSLINYDIIQQNEKSYLKLTVTEDDTRFFLRFGLHYDEVFKTGLLLNATAKRLLVRNSTVSLDVVVGDKARFYLNYFIDNGYIPGFGLYASGMSLDLNDSDGNISSQWNWFRNEAFIQSVWRDKYAIGGGISHDYFEAKPAGEAGFSQSGNFINPYAFIKSDTQDDKNFPSKGLLLSAEGKFMDVLNDAQDGQTFQTKITTQINFPITSWFTYRLGLFGGFTIGESIPDYYLYRIGGIFEQNLGNFVKFAGYEFGQLSARNILTANNTLQFNVYNNYYVDAHVNIANLFDNIQVDDIVHISESAAGVSAGLKSTFGQIKFNYSRSINRKNNAFSVILGHWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T2</accession>
    <name>C6X3T2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical cytosolic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782217.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07070">
        <property type="protein sequence ID" value="ACU07070"/>
        <property type="gene ID" value="FIC_00615"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00615"/>
    <dbReference type="eggNOG" id="ENOG5032SP8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099857_1_0_10"/>
    <dbReference type="OMA" id="CPDSVDQ"/>
    <dbReference type="OrthoDB" id="1887623at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="1">
        <location>
            <begin position="114"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="217" mass="25066" checksum="DFF6E86EC000E3AC" modified="2009-09-22" version="1">MTKKLTILIMGLFSLFGCGQKNSLTNTEKELLNKLTFNTELLTELKSLTKTELIQLPAIDQETGDVLNDKFFNGIFTETTEEKAIEYVKKLKTKFREKGYLIFVFEGEDDKKNIAVIKGTDDLDILRYRRTDGINHDLENEDIVKKISEWKSKYGLIVIGCSRDWLQVEFDKLPNDIDAFANEVYEFCPDSVDQGVGSIDKLKEAIKEMNGIWLWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W3</accession>
    <name>C6X3W3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ordered locus">FIC_00646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782247.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00646"/>
    <dbReference type="EnsemblBacteria" id="ACU07101">
        <property type="protein sequence ID" value="ACU07101"/>
        <property type="gene ID" value="FIC_00646"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00646"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_1_4_10"/>
    <dbReference type="OMA" id="GMRQLKD"/>
    <dbReference type="OrthoDB" id="1907955at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="107" mass="11931" checksum="592F44FB23F0A2F2" modified="2009-09-22" version="1">MELSIGEMLLIGVAIVVLFGPDKLPQIARDLGQGMRKMRGAMEDVKTEILKETDNPISEIKKEIDRVKQAAKDYNPVADLDKEAYAKRDEPKVNVADNDLHEGPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W6</accession>
    <name>C6X3W6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00649"/>
    <dbReference type="EnsemblBacteria" id="ACU07104">
        <property type="protein sequence ID" value="ACU07104"/>
        <property type="gene ID" value="FIC_00649"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00649"/>
    <dbReference type="eggNOG" id="ENOG502Z85F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066824_2_0_10"/>
    <dbReference type="OMA" id="NFTNGFR"/>
    <dbReference type="OrthoDB" id="959247at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032315">
        <property type="entry name" value="DUF4846"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16138">
        <property type="entry name" value="DUF4846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="289" mass="33210" checksum="CD850737A5A2B82A" modified="2009-09-22" version="1">MDKHPLLIKLRHIVLLSLLTIQGLHSQVVETTEPLVIDPGKSKINTRFSPPKGYVWVKQAKGSFSEYLVNFPLHPPGFPIRDYRAVPVENQENHLAILKIDVGDKDLQQCADAWMRLYAEYLWSQKRFDEIGFEFTSKQFFSWNDYRRGIRTREVKKRVTFYETGIADESYLAFRQYLNVIFRYAGTISLDRESVAVRSNSDIKPGDLIIKPGSPGHSVIIVGVARNSLGKRLYLLAESFMPAQDVHLLKNLGNPEISPWYELDVDAPKTVTAKYTFKPTLIKRFHAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X5</accession>
    <name>C6X3X5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782259.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00658"/>
    <dbReference type="EnsemblBacteria" id="ACU07113">
        <property type="protein sequence ID" value="ACU07113"/>
        <property type="gene ID" value="FIC_00658"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00658"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_4_10"/>
    <dbReference type="OMA" id="ASWCGNC"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="102" mass="11631" checksum="50A30FF4945F0E03" modified="2009-09-22" version="1">MYTELADDTLQQLVADNEKVVVQYGATWCGNCRIMKPKFKKLASENDDIPFLYVDAEKFPESRKLAKVDNLPTFAIFKNGELVNQVQSNQAESLINLFNELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X9</accession>
    <name>C6X3X9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782263.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00662"/>
    <dbReference type="EnsemblBacteria" id="ACU07117">
        <property type="protein sequence ID" value="ACU07117"/>
        <property type="gene ID" value="FIC_00662"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00662"/>
    <dbReference type="eggNOG" id="ENOG502Z7I5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085065_1_0_10"/>
    <dbReference type="OMA" id="IPEYGRH"/>
    <dbReference type="OrthoDB" id="1452595at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025632">
        <property type="entry name" value="DUF4290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14123">
        <property type="entry name" value="DUF4290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="217" mass="25763" checksum="D0D8B0B302505E6B" modified="2009-09-22" version="1">MEYNTSRPQLHMPEYGRIIQQLVERCKELETKEERNEMAVAIVDFMGQRNPQLRDEDNYKHKLWDHLFILSNYDLDVDPPYPFPTEEELQVKPKRMEYPKLQGDFKFYGKSILQLIDKAIELEAGDEKDALIAVIANNMKKSYNVYNKEHVQDEVIFRHLKDLSQNRLDLTGLDSLDRSKIYYATNRNNKTNGRNGQNPSQNSQNKKRNFHQNKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y5</accession>
    <name>C6X3Y5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Malate synthase</fullName>
            <ecNumber evidence="2 7">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782269.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00668"/>
    <dbReference type="EnsemblBacteria" id="ACU07123">
        <property type="protein sequence ID" value="ACU07123"/>
        <property type="gene ID" value="FIC_00668"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00668"/>
    <dbReference type="eggNOG" id="COG2225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_10"/>
    <dbReference type="OMA" id="CHKRGAP"/>
    <dbReference type="OrthoDB" id="322024at2"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="525" mass="60275" checksum="9C1966CDC42D8FB5" modified="2009-09-22" version="1">METSTTFRITAANRYEDIFSPELVEFLSALHTKFNSGRKRLLISRAMRQADFDQHRLPSFMSETEKIRKGEWICAPLPKDLQDRRVEITGPVERKMIINALNSGASTFMADFEDSNSPTWKNCIEGQKNLSDAVSRTLDFENEAGKRYKLNPVTAVLLVRPRGLHLEEKNIIIDGETASASLVDFGIYFFLNAKKLLENGSGPYFYLPKLEHYLEARWWNEVFMFSQDYLGIPQASIKATVLVETITASFQLDEILYELKEHSAGLNCGRWDYIFSYIKKFRNLPEFIVPDRDQVTMRSPFMSAYSKRVIQVCHKRNVHAMGGMAAQIPVKNNEEANEAAYSKVRADKEREVKNGHDGTWVAHPGLVPVAREIFDKLMPEKNQIHKKFEEYQISEADLLEIPKGTVTETGVRKNINVGILYIESWLMGVGAAALYNLMEDAATAEISRTQVWQWLNNEARLDDGRTLLPGMVLKWQEEELEKIREYVGAERFENGKFKLAAEIFDELVLNENFAEFLTLKAYNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z1</accession>
    <name>C6X3Z1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782275.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00674"/>
    <dbReference type="EnsemblBacteria" id="ACU07129">
        <property type="protein sequence ID" value="ACU07129"/>
        <property type="gene ID" value="FIC_00674"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00674"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043257_0_0_10"/>
    <dbReference type="OMA" id="METGGMK"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047474">
        <property type="term" value="F:long-chain fatty acid luciferin component ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007534">
        <property type="entry name" value="LuxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04443">
        <property type="entry name" value="LuxE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LuxE" evidence="1">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="LuxE" evidence="1">
        <location>
            <begin position="164"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="348" mass="40096" checksum="BE73C2CF811ED5F3" modified="2009-09-22" version="1">MVNNIFNIKTESEFRQACLETFRYQYQNIEIYRKFVGYLNIDPQTVDAVEKIPFLPIEMFKNHVVTDRNLPAEKYFQSSGTTQLNRSKHYIADFNLYEESIYRSFSTFIGAPEDYVFLGLLPNYSENPHSSLIYMVDFLMKKSGKPQNGYFLYNHAELFDLLSQLSLQNKKVILFGVSFALLDYLDFCKTLSQNHSNTQILNNSNTLTVIETGGMKGRKEEMTKDELLKILQKGFSTDKIYSEYSMTELLSQAYSMGENIYETPSWMRILVRNTEDPFSYVEAGRTGALNIIDLANRHSCSFIATQDLGKILTDSEKASSTSFLRNNRFQVLGRIDHSDIRGCSLLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X401</accession>
    <name>C6X401_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Outer membrane hemin receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782285.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00684"/>
    <dbReference type="EnsemblBacteria" id="ACU07139">
        <property type="protein sequence ID" value="ACU07139"/>
        <property type="gene ID" value="FIC_00684"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00684"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_10_0_10"/>
    <dbReference type="OMA" id="GVEHAPN"/>
    <dbReference type="OrthoDB" id="439303at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973435" evidence="5">
        <location>
            <begin position="20"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="120"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="329"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="793" mass="89301" checksum="9677D1EBC7657414" modified="2009-09-22" version="1">MKQLIKLVFFLFGITLVSAQQTFSVSGTVLDFHDKSALSNARIRLQNYNVVSDINGRFVVNKVSAGTYLLEVTHPDCETFSKQIKVESDIELTINLEHHSGDIEAVTIHGNHPIAGSVMIRTLSQEDISRNSTDNLGNLLKNISGLTALKTGNNISKPVIHGLYGTRISVINNGVKMAEQEWGVEHAPNVDVNQFEHIDVVKGASALKYGNESVGGVVVLEPAVVPKKDTLIGSVRLSGISNGKGAEVSAEALKSWENQWFVKSGGSYKKLGDQYVPHHTLQNTGAEVNSFNFSFGKHSFLHGFDVSYSGIQQEFGIFKGAHLGGPEDFYNAINFGQPYFLDDFSYDIANPRQSVRHHIAKIAAYKRFSGLGRLSFQYSFQQNSRKEYDIRKGDLNEIPSMDLTLTTHKAELFHLLERGNWSLESGISGSAQINFPDPATEARRLIPDYYRYDAGIFSVFKYSFTDKLNAEVGARYDFSRYDAYKYYDKSAWLNYAEEFPEFVVQESGSRILARPILDNHSTSANLGFNYIPTRHWNLKLNFSRTERAPNAAELFADGLHHSAAIMEEGDLRIKKEAIYSVNFSATAQAKWLRGFTLEVNPYFMYSDSFINQIPTGVKSTNRGVFVVWSYRQIEARMMGVDVDAQLQITDNLKWFSSFSALKGGDLSGNEPLILMMPANLRNALEWKSGKKSNFYIRVENENSFKQKRFPIRNQTVDFIENGVLVTREIDYSSTPASFSVFNASVGADVFKNVNLNFKVNNLLNTDYKEYLNRLRYFMSDPGRNFVATVQFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X404</accession>
    <name>C6X404_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782288.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00687"/>
    <dbReference type="EnsemblBacteria" id="ACU07142">
        <property type="protein sequence ID" value="ACU07142"/>
        <property type="gene ID" value="FIC_00687"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00687"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_0_10"/>
    <dbReference type="OMA" id="FEREMKD"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="214" mass="23363" checksum="C1CFDC62DA4984FB" modified="2009-09-22" version="1">MSDHFELLDIYKAVISMVAGLILGFEREMKDKSAGLKTITIICLGSTLFSIISYKLAGVGDPTRIASYVVSGIGFLGAGVIFKEGFTVYGLTTAGVIWIAAAIGVSIGFGEVYMAFTFLTAAIIVVNSATYITKHFMPQSFNKIVKIQMLEANFPQKPAILKEIKSIATNLSEIAIEKKDGHILITLDLQIGPKQIEKLEEYLTTNPSLDYFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X410</accession>
    <name>C6X410_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA Pol III Epsilon Chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782294.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00693"/>
    <dbReference type="EnsemblBacteria" id="ACU07148">
        <property type="protein sequence ID" value="ACU07148"/>
        <property type="gene ID" value="FIC_00693"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00693"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061549_0_0_10"/>
    <dbReference type="OMA" id="QTIFHKM"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="29028" checksum="B7A002E6CB468801" modified="2009-09-22" version="1">MNLKLYKPLCIFDLETTGVNVAKDRIVEISILKVNPDGSRESKTWLVNPEMYIPKESTEIHGISDDDVKNSPKFKEIAPKVMEMITGTDLGGFNSNRFDVPLLAEELLRAGIDFDLTKFKLVDVQTIYHKMEPRNLSAAYNFYCKKELVNAHSAEADVLATFEVLDAQVAHYNELPNDIAGLSEFSHHHKFADLAGMIRFDDDEQEVFSFGKYKGQRVKDVFQKDLGYYGWIQNADFPLYTKKVLTSIQLRSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X421</accession>
    <name>C6X421_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00704"/>
    <dbReference type="EnsemblBacteria" id="ACU07159">
        <property type="protein sequence ID" value="ACU07159"/>
        <property type="gene ID" value="FIC_00704"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00704"/>
    <dbReference type="eggNOG" id="COG1678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057596_2_1_10"/>
    <dbReference type="OMA" id="IYWGGDF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="183" mass="20667" checksum="90EA7C6DF91C1AC7" modified="2009-09-22" version="1">MMNYSYKGKIIISTPDISGDIFSRSVVLVIDHNAEGAFGLILNKKNQNMSARLLNIFGFRVDVYEGGPVENDKIFFINKGEKVTESFSEINDGFYLTEDIENVVAAIIEGRLSAEDIKVFSGYSGWAPGQLENEIRRKLWTVVDVYNLDYTLPTDHSLWKNIMQNLGGEFLLWANAPEDLSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X425</accession>
    <name>C6X425_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782309.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00708"/>
    <dbReference type="EnsemblBacteria" id="ACU07163">
        <property type="protein sequence ID" value="ACU07163"/>
        <property type="gene ID" value="FIC_00708"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00708"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_0_0_10"/>
    <dbReference type="OMA" id="AGPWHFA"/>
    <dbReference type="OrthoDB" id="1819626at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="344" mass="38443" checksum="2C5BA3C133928AFF" modified="2009-09-22" version="1">MTDNKKSSSLKNLLTIGVSLAVAVLFMWYALKGMEFDRIAGYFAKANYFWVFVASVFGILAYWFRAVRWNLLLEPLGHSISNSNAFWTISFGYLMNLTIPRSGELARSTALFGVEKVPVNKSFGTIILERVVDLVCMGLFLALTLLFKYDAILAFYRYVTEQKANADEQPNNYLYYFIGAALLISVLFFLLRQKLQQMALYQKAANFGKGIFHGLMSIFKLKQKGRFILLSLAIWVCYYLAAYLVCFALPETSNFTFADGFFIIVVGTLGMMIPASGGIGAFHLALKFGIMALFLSTGKDPEAGGEVGLSYAFISHTMQLVIMIVMGIISIPVLARARNRSIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X435</accession>
    <name>C6X435_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782319.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00718"/>
    <dbReference type="EnsemblBacteria" id="ACU07173">
        <property type="protein sequence ID" value="ACU07173"/>
        <property type="gene ID" value="FIC_00718"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00718"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_2_10"/>
    <dbReference type="OMA" id="ERTQMIG"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="31"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="304"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="409" mass="45148" checksum="9D7E0663AF70DA80" modified="2009-09-22" version="1">MKFPLYFSKKIAFSKDNKNNLSRVIVFIGRLSVALGVIVSLLTVSTGVGSKRAIKERMADFSGHISIKSKQSNSSYNSSVLTTEGLQLDKIKALPDVATTQNFVAVSGILRNEHNFAGIIFKGVGKDFDAERFKKFLISGTTPAISEDGFNSGIAISQKIAQDLHLNVKDSIVAVFSKESRSPLYRKFEVVGIYKTDIKMIDDLFIIGDINHARRIQGMKEKQTGGIDVFLKNINNIDDDAPVIDKLAGYKNYTVKATEEYPQIMDFIAIFDTNIALIIGIMLVVVIINIVMVLLILIIERTNSIGLLKTLGATNGQIRTIFINYTLMIMIPGLVLGNIIGLGFLLIQKYFGIITLNPENYYISVVPVDLNFVHILAISLGILLVSAFALILPSYLISKISPVRSIKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X450</accession>
    <name>C6X450_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cold-shock DEAD-box protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782334.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00733"/>
    <dbReference type="EnsemblBacteria" id="ACU07188">
        <property type="protein sequence ID" value="ACU07188"/>
        <property type="gene ID" value="FIC_00733"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00733"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_10"/>
    <dbReference type="OMA" id="LPQGMPK"/>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="232"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="571" mass="65453" checksum="C7A3DE2DDD4D4E7C" modified="2009-09-22" version="1">MNLFTETNLSPEILKAIGELGFESPTEIQKQTIPFISTDIRDLIALAQTGTGKTAAFSLPILDMIDDGSRKIQFLVLCPTRELCLQITKDIKNYSKYMNNIKTTAVYGGSSITDQIRSLRDKPQIIVGTPGRVIDLINRKALDFSEIQWLVLDEADEMLSMGFKDDLETILRETPETKHTYLFSATMNKEVERISKSYLTAPHRISVGSINEVKKNIKHEFYVVGYRHKKEALKRLIDANPNQYSILFCRTRMETQEVADFLMQNGYAADALHGDLSQAQRDTVMKKFRLKNIDILVATDVAARGLDVDSLTHVIHYSLPDDPEVFVHRSGRTGRAGKDGISMSLIKPEESRKLKQIKMSTKIDIVEKKVPTGDAIIKAQVGGVFEKLFTEHLEFFNFDDALIPDLSEFTKEELVHKMLQLQLRELAMFYKDKNDLADQKFNADDRGGDSRRDRDRDRGRDRERGGDRGERREFSRDGGRESRDRKPRRNNTDMVRFFFNLGKKDQLKKMDMLEIINKSTAKSKKRPDIGDIEILEKFSFFEVEKSFKDEVMKGMQSQKFKGKEMRAEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X459</accession>
    <name>C6X459_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00742"/>
    <dbReference type="EnsemblBacteria" id="ACU07197">
        <property type="protein sequence ID" value="ACU07197"/>
        <property type="gene ID" value="FIC_00742"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00742"/>
    <dbReference type="eggNOG" id="ENOG503319I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2734103_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="71" mass="8159" checksum="BB81DA53DB6B9D9E" modified="2009-09-22" version="1">MLDSLNPKALNNYYGNKNVTDLPTSNLRITFADGTQKNIEDYGKRGTQKLDELYDFIEGLRKTQTWTKVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X498</accession>
    <name>C6X498_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00783"/>
    <dbReference type="EnsemblBacteria" id="ACU07236">
        <property type="protein sequence ID" value="ACU07236"/>
        <property type="gene ID" value="FIC_00783"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00783"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_14_1_10"/>
    <dbReference type="OMA" id="HHNAAED"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="21223" checksum="C8D77C5AC178AEE4" modified="2009-09-22" version="1">MIDFCAIDFETATHERNSACEMGICVVEDGQIVKTQTWLIKPPNYPYFHPRNIDVHGITPRDVQDSPTFDEIWHEAENLMYGNLMVAHNAGFDAGVLRSCLDYYGFYKPKLNYLCSISIAKKSWKNLPKYGLKSLAEQHQISFKHHRAGDDAEVCAKISLLAFEKLMITRTDEVHDVMKKNLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A3</accession>
    <name>C6X4A3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00788"/>
    <dbReference type="EnsemblBacteria" id="ACU07241">
        <property type="protein sequence ID" value="ACU07241"/>
        <property type="gene ID" value="FIC_00788"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00788"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_10"/>
    <dbReference type="OMA" id="RHGKRWM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="4"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="457" mass="51583" checksum="74969CC19FAB36B6" modified="2009-09-22" version="1">MKTEMNFEDILAAQRTFFETQKTKSVKYRKIYLEKLRDVIQSNEALLYDAIYKDFGKSKFDTFTTEISFVLNDIDYYLKNLTALAKPKRVKTNLANQLGTSRIYSEPLGCTLVIGAWNYPYQLSLSPMISALAAGNTCILKPSEVAENTMRLMAEIINANFPKEYLFVAEGGVEETTEILKLRFDKIFFTGSTKVGQIVYEAAAKNLTPIILELGGKSPVIVTSSADFEVASRRIIWGKFLNAGQTCVAPDYILVDEKVKDSFLDALKSQIVKFKYTPEAEHYTRIINDRNFSRLASLLDSSTIYFGGNHNADTRYIEPTILHPVNWEDVVMQEEIFGPILPVLTFKNFNEALHKISEKAKPLAAYLFTQNDGEKAQFLSRISFGGGCINDVMMHLSNENLPFGGVGHSGMGNYHGKFGFEAFSHQKSVLDRATWGEPELKYPPYTAKKLSWIKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A6</accession>
    <name>C6X4A6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase, synthetase subunit</fullName>
            <ecNumber evidence="6">6.3.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00791"/>
    <dbReference type="EnsemblBacteria" id="ACU07244">
        <property type="protein sequence ID" value="ACU07244"/>
        <property type="gene ID" value="FIC_00791"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00791"/>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003100_2_0_10"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010141">
        <property type="entry name" value="FGAM_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01857">
        <property type="entry name" value="FGAM-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="5">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="394"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1194" mass="131386" checksum="70717DDCB9D49ABE" modified="2009-09-22" version="1">MYNIYDVFGLDSEELDQVIGNTFVDPVTDVLHNENPATNLFFATEFLPGQYDQRADSAQQCIALLTGIESSTVRSGKLIDISGVSEADLRKIKNHLINKVESQEKDLSVLEIPKEEAPDSVIVHEGFISFSKDELQDFYHDHGFALGLDDLEFIQNYFKSERRNPTETELKVLDTYWSDHCRHTTFETELTDIQFNGEFKSTLEHIFDDYLEKRKFLGREAKPISLMDLATVCARYFHKTGNLENLVVSDEINACTVEIEAEYDGKKEPWYLLFKNETHNHPTEIEPFGGASTCLGGAIRDPLSGRAFVYQAMRLSGAGNVLEPVSETLPGKLPQRTISKQAANGYSSYGNQIGLATTLVNEIYHEGYKAKRMEVGFVVGAVKKDWVRREKPLAGDLVILLGGATGRDGVGGASGSSKVQDETSIHTLSTEVQKGNAVEERKIQRLFRNPDVTRLIKKSNDFGAGGVSVAIGEIADSLEINLDILPLKYGGLNGTELAISESQERMAVVIEAQDKDRFIKYCENENIKAVEVARVTDSRRMQMFWQGSMIVDISRDFLDTNGCTKSQNAVISHLNKIEKQTISFNEQNFLKALADKNSASQKGLAEMFDASVGGTTVAMPFGGRYQLTEMEGSVQTLPILNADNVETVSFASWGFDAAVSSQNSMIGAANAVVESVAKIVAMGGDYTKIRLSFQEYFEKLGNNPVKWGKPLASLLGAYDAQMNFGLAAIGGKDSMSGSFQDIDVPPTLISFACADGKKANVISPEFKETGNKLYLYNHIPKENGLPEYKNLTDIFSFIFENIKSGNIVSVKTVKAGGVAVALAKMSFGNLLGANVEVSESLLLSENVGSFIIECKNEMKVSSLQLIGEVKNSEILKINGLDFNIKNLLEANTLTFENLFPTVEGKKSVLEIDAKYNGTKAEQIKIVSHKLAKPRVFAPIFPGTNCEYETQNAFRKEGAEVIGLPLINLNHQLLNESLDAWIAEIEQSQILVFSGGFSAGDEPDGSAKFIVNVLKNARMKDAVHRFLERDGMILGICNGFQALVKSGLLPFGEIRDLDENSPTLAHNSIGRHISQMADVRVISDHSPWLKGMKDEVYTIPLSHGEGRFVAPAGVIQELYQNGQIATQYVGVDGNIAHGMPFNPNGSLFGIEGITSKCGKIYGRMGHPERYADGLLKNIPTAAYHNIFKNGVEYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B7</accession>
    <name>C6X4B7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782401.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00802"/>
    <dbReference type="EnsemblBacteria" id="ACU07255">
        <property type="protein sequence ID" value="ACU07255"/>
        <property type="gene ID" value="FIC_00802"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00802"/>
    <dbReference type="eggNOG" id="COG4994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007428_0_0_10"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973684" evidence="1">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="164"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="276" mass="30692" checksum="64E034F5ED5C9ECB" modified="2009-09-22" version="1">METLNRLMMLALVLFNALLVAQNSDEEKVLQINSAYDKATLSGDVSYFERVLAPNFVGYHPDGSVGTRAEVLEKLKNEKAKPTYRLLSMTSDDVKVKVSGDLAYVTGKWKASTSGIDSNPIPHEDTGYYGSVFEKQNGNWLLVADHSSEKAHTAEELEPSLKTASEKYDEAIRTKNVNLLDQLLSAEFISINEEGKMNNKSEEMAQLGTSDLVISSLTTSDKKFKIHRSTALETGIFEVKGLFKKQAFAEKGRYSSVWFYSGGKWLLVSDHSSIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C1</accession>
    <name>C6X4C1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00806"/>
    <dbReference type="EnsemblBacteria" id="ACU07259">
        <property type="protein sequence ID" value="ACU07259"/>
        <property type="gene ID" value="FIC_00806"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00806"/>
    <dbReference type="eggNOG" id="ENOG5031J2R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144168_0_0_10"/>
    <dbReference type="OMA" id="KSFPRKW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025364">
        <property type="entry name" value="DUF4268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14088">
        <property type="entry name" value="DUF4268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4268" evidence="1">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="154" mass="18833" checksum="A0D16CA39EB73839" modified="2009-09-22" version="1">MIAFPFSNNVVNMFTKQEAQQLRTEFWIAFGKSFPRKWLLYDTKIKDFSFKFYADNKKAEVSLDIEMKDELFRNAYYEKIWSLENMLEEEVGAFHKDEFYTLENGKVIARIWVTKENVSILNKNTWQEIFEFFVEKMDGFERFYYEYEDFIKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K5</accession>
    <name>C6X4K5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III delta subunit</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782489.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00890"/>
    <dbReference type="EnsemblBacteria" id="ACU07343">
        <property type="protein sequence ID" value="ACU07343"/>
        <property type="gene ID" value="FIC_00890"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00890"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044694_3_0_10"/>
    <dbReference type="OMA" id="EEPYYID"/>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="345" mass="39949" checksum="9CCAEAF44BC6BF58" modified="2009-09-22" version="1">MKELDSILKNIKNKELLPIYFFHGEEPYYIDAAVKSFENDVLDEDEKAFNQTVVYGKDTTFSDVLSLARQFPMMGDRQVIILKEAQEIKIVEKELEALKVYVQNPVPSTLLVIAYKYKKIDARKAFAKTLSKNKMLFLSEKMYDNEVPRWIDQQIRNLGLRTKPNIPALLSEYLGTDLSRISNELRKLKMILNDTDILDEKIIETHIGISKDFNIFELTKALSNRDEAKAMRVAHFLGKSPKQNPFEMMMGSLYSFFSNLIIYHTMAGQNPKAIQDEMRLNYYQAQDMAAASKHYSLKHATRIISILREFDLKRKGLGAVNMNESELMTEMTYKILNVAKFKVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L7</accession>
    <name>C6X4L7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782501.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00903"/>
    <dbReference type="EnsemblBacteria" id="ACU07355">
        <property type="protein sequence ID" value="ACU07355"/>
        <property type="gene ID" value="FIC_00903"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00903"/>
    <dbReference type="HOGENOM" id="CLU_1101595_0_0_10"/>
    <dbReference type="OMA" id="RNCTATI"/>
    <dbReference type="OrthoDB" id="2103505at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="252" mass="29682" checksum="CF6C69A5C3ADA36F" modified="2009-09-22" version="1">MNYYILSKEVEPKIVGVKDGGGQLGVDSRLDTIYNDWYNNIFFKLPREDKHNAWKLKLKHETYALKPLEGLVFKKGAKKTDYVGEGLLGLYVNEKLKTILESSHLPNHRFIKTPFIEEKTGKIIDEYWRFVHDLETGEDTIDFEKSEFNFKYHKRNFGEDFYREVNSYEDYMNVFYETGTAPSVSKLVLNENFDKELDFFKFQFLSSNMYVSERLLNKMQEAGITGYSVMTLEKDKMRSEVLGDVHTELIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N4</accession>
    <name>C6X4N4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ordered locus">FIC_00921</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782518.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00921"/>
    <dbReference type="EnsemblBacteria" id="ACU07372">
        <property type="protein sequence ID" value="ACU07372"/>
        <property type="gene ID" value="FIC_00921"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00921"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_10"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="415"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="706"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ACU07372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="800" mass="89171" checksum="C46ECADBF4C3B743" modified="2009-09-22" version="1">MKISNNWLQDFIKTDLKADKTAEYLTDIGLEVEGIDKYESVKGSLEGIVVGKVLTCSQHPNADKLKKTTVDVGGGKILNIVCGAPNVEAGQTVPVAVVGTQLFMKDGSPLVIKEAKIRGEVSQGMICAEDELGLSDDHGGIMVLDENKFEVGKNFADYFELTSDEVFEIGLTPNRTDAMSHYGVARDLNAVLTSNQIKSTFEKLESKTLNITGTADFQLEVEDDALCPRYIGAVIENVKVADSPDWLKDRLKAIGLSPINNIVDITNYILHGFGQPLHAFDADKIEGKKVIVGVNAEGTKFTTLDNIERTLNGSEIMIKDGAGKPMCIGGVLGGQTSGVSTETQTVFLESAYFNPVAVRKAAKHHGLNTDASFRFERGVDPNSTRTAITHAIAMIEEVAGGKLAGALLEHYPEKIENNYVILRFSKVEQILGTKIHREKIKEILKLLDIQVLNEIQNGLEISVPAYRADVTREIDVIEEILRIYGYNKIDSPQKISFTPARLNPEDQDALENAWARTLQSNGFNEVMNNSLTSVKDETHAVKLLNPLSSDLQFMRKSLLEGLLENADYNIKRKTADIKFFEFGKVYHKTDKYVERKQLAMLVSGRNNAENWLLAKCATDFWYLKSYVKTLLDKLNLNIEEKSLEDARFSDALELAADGKTIARLGKVSTELLKGADLDQDCFYAEIELETCQQLRSTGTFKFNDIPKFNKIRRDLALLVDKNVTYAELYQQARKNPSKYLKNINLFDVYEGKNLPEGKKSYAMSFELLNEDKTLEEKDISEVMNSLINGFKKEFAAELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U3</accession>
    <name>C6X4U3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00980"/>
    <dbReference type="EnsemblBacteria" id="ACU07431">
        <property type="protein sequence ID" value="ACU07431"/>
        <property type="gene ID" value="FIC_00980"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00980"/>
    <dbReference type="eggNOG" id="COG3865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054535_0_0_10"/>
    <dbReference type="OMA" id="GWVQDKY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="125"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="289" mass="32892" checksum="D25C6C73BCAB3E2E" modified="2009-09-22" version="1">MNSMKNNIFPCLWFNLTGNEAAKFYIEVFGGKITVDTPSVTNFELFGQCFMILDAGPQFKKNASVSFMVMCDTEEEVEKYWKLLSENGTVLMELGDYPWSKKYGWVQDRYGVSWQIYLGGHAGAQKIVPTLMFIHQNNGKAMNAVEYYTQIFPDSSILEVSRYGEDGSDARENAGNVQHAHFKIDGYSLFCMDNSFDHQFDFNEAVSMVVMTDSQEETDHLWNSLTSDGGRASRCGWLKDKFGFSWQIVPKKLIELMNDPDPFKGRKVVEAMMAMEKIVISDLEAAYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V0</accession>
    <name>C6X4V0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07438">
        <property type="protein sequence ID" value="ACU07438"/>
        <property type="gene ID" value="FIC_00987"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00987"/>
    <dbReference type="HOGENOM" id="CLU_3373896_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="34" mass="4004" checksum="809882B0DD9B0620" modified="2009-09-22" version="1">MLHIIVFAIIYKTLLLSLLKNKENVRMEGLIYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V5</accession>
    <name>C6X4V5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine protease</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782589.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00992"/>
    <dbReference type="EnsemblBacteria" id="ACU07443">
        <property type="protein sequence ID" value="ACU07443"/>
        <property type="gene ID" value="FIC_00992"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00992"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310316_0_0_10"/>
    <dbReference type="OMA" id="SYATPHV"/>
    <dbReference type="OrthoDB" id="214691at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="9">
        <location>
            <begin position="576"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="948" mass="105828" checksum="45993369B66634BD" modified="2009-09-22" version="1">MATQTIINDLAYERFQQATAQIQTIKKGIHDTRMGEATLTDIQTDSEKLSKRIARENMPISAALERINGVPNFQDIQILYKILKIAESVGRITIKTRYGNSGYGTGFLLAPGILITNNHVFPDADTAKNSIVQFYYELDEHNEAKKVQTFGFLPEKLFLTSSFKVDSNIPDSGLDFTIVAVSERSKEGKNITEIPHTMMDEHYGKIIEGENCVIIQHPKGDYKKTVMKDIRMLTLKDDFLIYESDTLPGSSGAAVIGLGTGEVVALHHSSIPNKNPQGQWLRKDGGVYKDGDADETIDWLGNEGVRVSSFIRAIRSAVLPGEMNDLKNSIFGKESHGESHNKPVSNRTETPITEMKNSPESVLNQAVNKLQTSTQSPDSPLQYFELELSNIQTMQADWKESYKKLVPEIISSEPLFPMSTIPSQKAIHYVTLRSGQNPWEVAAKLEALPRIKTATPDLEVETDLQMKSESYKQFTESDMLESMKTSNAVGRQDDFKTKWSASSYFNLDDADTLKQRLWNRTAVGLSDETAAESNIVELLKKISGQKAEEENNPEEQHADSVEKILQNLRNILLVQLDTGYTDHAKVKGRFNLNCDEDFIDGSDARDDMRKGLLRHPGHGTRTASIITGGDMQSVYKNDGNYGILCDGNKDSLVSIIPYRISESVVLINRGKNVVDAVNQAINTNTDVMFMCMGSYPRPMLAEAAKAAYDNGVIWVCASGNEVEMVVSPALYPGTIAVSATNPNQKPWRGSSYGFEVDISAPGEDIYVPSMDEKYKEIMVYGSGTSYATPHVAAAAALWKAKNRDELLKKYKFPWQTVEAFRICLKESSTKPADWDTENYGAGILNIYKLLLSELPEIEPNKYAYANDTRQEWDLGVREGIHFLWKTLLKKTISTHESAHEMILTERSRIALSAMTGNTASSIFESDSITAVTDSEKILKMYFDSYKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X4</accession>
    <name>C6X4X4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01012"/>
    <dbReference type="EnsemblBacteria" id="ACU07462">
        <property type="protein sequence ID" value="ACU07462"/>
        <property type="gene ID" value="FIC_01012"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01012"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_39_2_10"/>
    <dbReference type="OMA" id="FLVEMFP"/>
    <dbReference type="OrthoDB" id="446363at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="41"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="546" mass="60853" checksum="95E2AA51B0548A5A" modified="2009-09-22" version="1">MVYQNITLTKNNNSMSKKFKTQQEHDDYVAEKKKNKTIWGVIMASSLGTLIEWYDFYIFGSLAVVLATKFFPADNPTAAFLSTLATFAAGFVVRPFGALFFGRLGDIIGRKYTFLVTLLIMGFSTFLIGCVPSFETIGYVAPVLVLILRLLQGLALGGEYGGAATYVAEYSQPHRRGYWTSWIQTTATSGLFISLIVILVTKTSLTPEEFDSWGWRIPFWISILMVGVSYVIRRNMKESPLFAQAKKEGKTSTNPLKESFGNKFNFKFVLLALFGAVMGQGVIWYTGQFYAMSFMQKVMNIESAQVDSMMALALFLGTPLFILFGWLSDKVGRKPIMMIGMLLAIIAYRPIYKAMFNSVKIENKVLAQNGLEEKRTAKPHAKLATDSVITYHTEKTFTDGTLLKRDSIVHWAAAGPAMVKGKAEAPLVKESIIVNPDTRWLLVLLVFIQVVFVTMVYGPIAAFLVEMFPIRIRYTSMSLPYHIGNGIFGGLLPAVATYLVTSGKDAGHAEWYLQGLWYPIIVAGVCLVIGTLYLKTKNKSLAEDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X504</accession>
    <name>C6X504_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805777.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01042"/>
    <dbReference type="EnsemblBacteria" id="ACU07492">
        <property type="protein sequence ID" value="ACU07492"/>
        <property type="gene ID" value="FIC_01042"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01042"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_2_10"/>
    <dbReference type="OMA" id="DAWKVYM"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="PTHR43521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="39"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="527" mass="57454" checksum="4E3B32E464499F2B" modified="2009-09-22" version="1">MTEQTTDYGIPQMLKNLGISQENKGVSSGGSFFATGDLLESYSPTDGKLISKVKTANADDYNTVIEKAKAAYKEFRMIPAPKRGELVRQFGLKLREYKDDLGKLVSYEMGKSLQEGLGEVQEMIDICDFAVGLSRQLHGYTMHSERPGHRMYEQYHPLGVVGIISAFNFPVAVWSWNTALSWICGNVTIWKPSEKTPLCAIACQNIINEVLKENNMSEGISTMIVGDHKIGEMLVNDKNIALVSFTGSTKVGRTVGKNVAERFGKSILELGGNNAIIITENADLDMSIIGAVFGAVGTAGQRCTSTRRLIIHESVYNEVKNRLVKAYGQLKIGNPLDENNHVGPLIDKDAVKQYLDSIEKCKKEGGKFAVEGGVLEGAGYESGCYVKPCIAEVENSFEIVQHETFAPILYLIKYKTLEEAIALQNDVPQGLSSAIMTQNLREAELFLSQAGSDCGIANVNIGTSGAEIGGAFGGEKETGGGRESGSDVWKYYMRRQTNTINYTASLPLAQGIKFDLDGDTKNEIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X536</accession>
    <name>C6X536_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805809.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01074"/>
    <dbReference type="EnsemblBacteria" id="ACU07524">
        <property type="protein sequence ID" value="ACU07524"/>
        <property type="gene ID" value="FIC_01074"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01074"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_10"/>
    <dbReference type="OMA" id="GIGLEYC"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="245" mass="26204" checksum="F45A942C973E0566" modified="2009-09-22" version="1">MKSVLITGANKGIGFETARQLLQKGFYVYLGSRDVENGIKAVQKLKAENLAHVEVIQMDVTDPASVNSARLEIGKKTSCLDVLINNAGINGGAPYTALEASKEQFMAAFNTNVFGVASVTQSFMGLLRKSPAPRIVNVSTSVGSLTLQSDPTWMGYDFAKYAVYGSSKAALNMLTVHLAYELRDTPFKVNAVCPGYTKTDFTGGNGGEVEEAAKRIVKYAMLNPDGVTGAFISEETNPATGSIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X538</accession>
    <name>C6X538_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PepSY-associated TM helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01076"/>
    <dbReference type="EnsemblBacteria" id="ACU07526">
        <property type="protein sequence ID" value="ACU07526"/>
        <property type="gene ID" value="FIC_01076"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01076"/>
    <dbReference type="eggNOG" id="COG3182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031962_2_0_10"/>
    <dbReference type="OMA" id="HRGRFFG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="407" mass="47454" checksum="19C844F1687516F6" modified="2009-09-22" version="1">MFSMRKKHPHSRPAKKSFLRTIAGKLHLWFGLSIGLIVFIVSITGALYVFKDEVQNCLRKDYLYHAEPGIESKKILPLSVLEQKVNQQTGEKYPLHWVDIPLDKSKTYKFYYYENDPEAWNYFDEFVIYKTAYVNPFTGKVLSVQDEKNGFFNIVKFIHWSFLLKSEWGKYVVGTPVFIFLLMVITGIILWWPKNRKARKQRLWFQWKNIKSWRRRNYDLHSIVGFYASFLAVVAAVTGLFYSFFFMQAIMYVVFSGGNTEYPDYSHITTTAPKEMRNAGTLDKMAAKVEELYPTASAYSLDFGHPHIDDHEHPNYEVFVKQLDYSYHINHQIIFDENSGEMLQNRPHKTKDFGQKYVAANYDIHVGAIWGIWGKILAFIVSLACASLPVTGFLVWYGRKVKGRAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B8</accession>
    <name>C6X5B8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805891.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01156"/>
    <dbReference type="EnsemblBacteria" id="ACU07606">
        <property type="protein sequence ID" value="ACU07606"/>
        <property type="gene ID" value="FIC_01156"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01156"/>
    <dbReference type="HOGENOM" id="CLU_1592099_0_0_10"/>
    <dbReference type="OrthoDB" id="1980644at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="18550" checksum="FDD023E9F7892F08" modified="2009-09-22" version="1">MFSTKLYTSGSSTATAIIALVFVLFTGSQKEPAPMKKALASETVVRKEINPASGQVLLAGITQQRKVAKPLKKSSKVRTSQPARIYKPGNSTGRRPSVSTVRSHEFIVTKYDRTALRIKPLMGSEVVANLKQGSKLIVLEREVSWYKVKVHLTGKVGYIHRYMVNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C8</accession>
    <name>C6X5C8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01166"/>
    <dbReference type="EnsemblBacteria" id="ACU07616">
        <property type="protein sequence ID" value="ACU07616"/>
        <property type="gene ID" value="FIC_01166"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01166"/>
    <dbReference type="eggNOG" id="ENOG5032T87">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149246_0_0_10"/>
    <dbReference type="OMA" id="KNQDRII"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045385">
        <property type="entry name" value="DUF6526"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20136">
        <property type="entry name" value="DUF6526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="132" mass="15550" checksum="5C448CF96534985F" modified="2009-09-22" version="1">MPHHFILLPALLVLLIFGITKIFNDEANKLIWILFSVVIFLIMYVAVMLRQHYALGNQNRIIRLEFKQRYFELFNKNSDQVISKLNFGQVAALRFAYDDEFRVLLGRALNEQLSGDEIKKAITKWRADHNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L4</accession>
    <name>C6X5L4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805987.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01254"/>
    <dbReference type="EnsemblBacteria" id="ACU07702">
        <property type="protein sequence ID" value="ACU07702"/>
        <property type="gene ID" value="FIC_01254"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01254"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142799_0_0_10"/>
    <dbReference type="OMA" id="NPAKKLY"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="156" mass="17172" checksum="BA5CCA5DE4AF10CA" modified="2009-09-22" version="1">MIVIKVYGDHHKADTTEIDTFTDFLFTNLEQFGDPKNDIRNAILYAMGEGQKPGGLVLTAADAETGEIYGAVVINKTGMSGYIPENILVYIATDKNSRGKGIGKSLMLEAIKLAQGDIALHCEPDNPAKHLYEKLGFTSKYLEMRLNNTKNVLYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M9</accession>
    <name>C6X5M9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="7" type="ordered locus">FIC_01269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806002.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01269"/>
    <dbReference type="EnsemblBacteria" id="ACU07717">
        <property type="protein sequence ID" value="ACU07717"/>
        <property type="gene ID" value="FIC_01269"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01269"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_10"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="278"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="363" mass="40676" checksum="C295C0E3EE5FB103" modified="2009-09-22" version="1">MKCGIVGLPNVGKSTLFNCLSNAKAQSANYPFCTIEPNLGTVSVPDQRLFELEKLVNPERVLPAVVEIVDIAGLVKGASKGEGLGNQFLANIRECEAIIHVLRCFENGNIIHVEGTVDPMRDKEIIDIELQLKDMEALGKAVDKAKKFIKSGKKEDVLTYETLLKLQKFVEDGKNAREFPADDFMKPIIEDIQLLTNKPVLYVCNVDENSIKNGNEWIAKIEEMAKKENAEVVVLAAQIEADINELESFEERQMFLEELGLEEPGVNRLIRKAYDLLKLQTYFTAGVKEVRAWTIGQGWTAPQAAGVIHTDFEKGFIRAEVIGYEDFKNYGSEAKVKEAGKMKVEGKEYIVKDGDVMHFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5N1</accession>
    <name>C6X5N1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl carrier protein phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01271"/>
    <dbReference type="EnsemblBacteria" id="ACU07719">
        <property type="protein sequence ID" value="ACU07719"/>
        <property type="gene ID" value="FIC_01271"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01271"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_4_2_10"/>
    <dbReference type="OMA" id="YGGVWAQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="20784" checksum="C32F3BA73848AB78" modified="2009-09-22" version="1">MNQLDIIMKKIAVLVGSLRKESFNRKIANEMIRLAEGKLELEIVEIGNLQLYSEDLDQNPTQEWTAFRQKIKSADGILVVSPEYNRTIPGALKNAIDVGSRPYGSSVWPGKPGAVVTSSVSSLGGLAANHHIRQAFVFVDVPLMQQPEAYIGNSSKIFGEDGKTVVPDTEKFLQTFVDTFQKWVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X2</accession>
    <name>C6X5X2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01362"/>
    <dbReference type="EnsemblBacteria" id="ACU07810">
        <property type="protein sequence ID" value="ACU07810"/>
        <property type="gene ID" value="FIC_01362"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01362"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114043_0_0_10"/>
    <dbReference type="OMA" id="VVANEHK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="24157" checksum="B87D685493BE9FFF" modified="2009-09-22" version="1">MLRLKKKYLILAPLLNTLSEILDIPKPEPKTETKTAAELPKEAAPTIIKTTEPVARKKIPSKYSISAVLEKTEVKDEVVANEHKEVLPSSHFTDTDLQNEWQKFLKDLQKEDVIVYNAISSFKLQKKDEDVVEITYPSESAKSEFEKVRAGFFNHFMHKVNHFNIIVEFKSDVSLKREIVTKRMIFDKFAAINPVLKELDDLFKFDFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X9</accession>
    <name>C6X5X9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ordered locus">FIC_01369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806102.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01369"/>
    <dbReference type="EnsemblBacteria" id="ACU07817">
        <property type="protein sequence ID" value="ACU07817"/>
        <property type="gene ID" value="FIC_01369"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01369"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_4_1_10"/>
    <dbReference type="OMA" id="QFVFKNA"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="111"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="251"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="340" mass="37343" checksum="1E9D2BDA5B2CC046" modified="2009-09-22" version="1">MIKSTIKGIGHYVPENVVTNDDLSKLMNTNDEWITERTGIKERHHRQNRNDAEETTAFLGFKASEKALEMAGLTAKDIDYIVFATLSPDYYFPGCGVLLQEMLGCDTIGALDVRNQCSGFVYAMSVANAFIKSKMYKNVLVVGAEIHSFGLDFSDEGRGVSVIFGDGAGAVILSAAEDESAGDILSVNMHSEGKYADQLCTKFPGSKYGWSDRMRLEPESVTNAEIYPVMNGNFVFKHAVTRFPETMMEALSSAGKTVEDLDMFIPHQANLRIAQFVQQKMGLPEEKVFNNIQKYGNTTAASIPIALSEAIAEAKIKRGDLVLLSAFGSGFTWGSVLFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z7</accession>
    <name>C6X5Z7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806120.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01387"/>
    <dbReference type="ESTHER" id="flab3-c6x5z7">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07835">
        <property type="protein sequence ID" value="ACU07835"/>
        <property type="gene ID" value="FIC_01387"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01387"/>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090325_0_0_10"/>
    <dbReference type="OMA" id="NREYHRW"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="240" mass="28445" checksum="37C2243A01AD3F95" modified="2009-09-22" version="1">MPRIEHTDFYSHILGIKLNVEVTGHYGYPIIMFPTSQGQYRQNHDFKLNDSISSLVEEGKVKLYNLETIDVYSFYDKKIHPSERIRNYEKYMQFLAQEFVPYLQKMHSEHRVAVAGASFGGYHAANFAFRFPDLVSHLFCLSGAFSIRNFMDGYDHELVYFNCPREFVLNDEAWKYRHMHIVLSTSDEDICLDQTKEMSGILHSKGIDHWYDEQKWISHDWPLWRMVFPKFVGRFFAKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X638</accession>
    <name>C6X638_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806161.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01428"/>
    <dbReference type="EnsemblBacteria" id="ACU07876">
        <property type="protein sequence ID" value="ACU07876"/>
        <property type="gene ID" value="FIC_01428"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01428"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_1_1_10"/>
    <dbReference type="OMA" id="FPMMSKI"/>
    <dbReference type="OrthoDB" id="1635499at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="189" mass="20894" checksum="5A4B4A10DF0B5DF6" modified="2009-09-22" version="1">MKKIFILMLGVAAFVQSCTQQKKEISQDKNTVMNSIYDFKVESLDGGEIDFADFKGKKILIVNTASECGFTAQYADLEEISKTYAGKVVVVGFPANNFGGQEPGTNEEIGAFCEKNFGVTFPLAAKVSVKGDDTAPIFKYLTDKDLNGVKNTSILWNFTKFLVDENGKLIDSFISTTKPTDEKITKYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X645</accession>
    <name>C6X645_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2807 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806168.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01435"/>
    <dbReference type="EnsemblBacteria" id="ACU07883">
        <property type="protein sequence ID" value="ACU07883"/>
        <property type="gene ID" value="FIC_01435"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01435"/>
    <dbReference type="eggNOG" id="ENOG502ZCAF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234245_0_0_10"/>
    <dbReference type="OMA" id="LEANCNC"/>
    <dbReference type="OrthoDB" id="1420923at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2807" evidence="1">
        <location>
            <begin position="34"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="233" mass="26356" checksum="0861627B44946D21" modified="2009-09-22" version="1">MKNLFLLYAVLTLISCGEISPKGNIESKDIPVEDFVNLDIKGKFRLFYIKSDSSFVNVESYPNILDNLKIKVKDKTLTIAEKRTTKAVDFYNITVYSKYNVEKIAVADSVEINLSSEIKTDNFRLSLKNNAKFIGSVNTRRAQLYMTEKSRANFLGKTNDAMIKISDSASLIAPYWAIVNLDIMSKNGNYAEVNVKDSLKGNIGNTAEFVYYNDPIRAFKIDKTANVQNRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X655</accession>
    <name>C6X655_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, family M14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806178.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01445"/>
    <dbReference type="EnsemblBacteria" id="ACU07893">
        <property type="protein sequence ID" value="ACU07893"/>
        <property type="gene ID" value="FIC_01445"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01445"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042010_0_0_10"/>
    <dbReference type="OMA" id="KILMWSQ"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="368" mass="42536" checksum="105FB2423287F9CD" modified="2009-09-22" version="1">MQTKITYRQNPDFPNRYISPEKLFLYLQANYSDCITEIGKSVLGRPIYKMSLAHGKIKVLAWSQMHGNESTGTHAMLDLLEIFKHQPELQHNLFTEISFDFIFMLNPDGSQKWTRRNALEIDLNRDFLKMSSKEFPILRNIVESGGYDYGLNLHDQRTIFSTNGTDPATLAFLAPSENYDRDITGTRKKSMAVIAKIFENLRNELPCGIARYSDEFYPASAGDNFTKMGLPTILFEGGHFPDDYKRTATRRFYTLALYHALNAIVDLRGTTHDWQLYQDIPVNKETHYDIIYRNVKLNLDYECVLDIAVQFREEFADGSDEISFVPIVMEVGDVGMKKGWKEIDCTGKTFVSQRKFPKLDEVVDFRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X689</accession>
    <name>C6X689_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01479"/>
    <dbReference type="EnsemblBacteria" id="ACU07927">
        <property type="protein sequence ID" value="ACU07927"/>
        <property type="gene ID" value="FIC_01479"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01479"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108463_1_0_10"/>
    <dbReference type="OMA" id="KANRFTA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="182" mass="21015" checksum="36A43415025990DA" modified="2009-09-22" version="1">MEGVCENPFFYLCVMKNYQIFLLLFFLPMLAFGQKNGVVINGWTNIGTFKCVNANFQNSRSIYSFSGSQLPNIPLQVVDFDCKNKIMTADFRKTLHSEKYPALTIKFINFTKLKANRFTALVEVKMMNVTKSYNIEFSEYHDSLVGNKRLKFSDFNIVPPKKMGGMVYVKDEIDLFFSLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E1</accession>
    <name>C6X6E1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyadenosine kinase</fullName>
            <ecNumber evidence="5">2.7.1.113</ecNumber>
            <ecNumber evidence="5">2.7.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.113" evidence="5"/>
    <dbReference type="EC" id="2.7.1.76" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806264.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01532"/>
    <dbReference type="EnsemblBacteria" id="ACU07979">
        <property type="protein sequence ID" value="ACU07979"/>
        <property type="gene ID" value="FIC_01532"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01532"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_1_10"/>
    <dbReference type="OMA" id="EAMVMTP"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004136">
        <property type="term" value="F:deoxyadenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004138">
        <property type="term" value="F:deoxyguanosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="4">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="204" mass="23652" checksum="C0A2868AFEC2D63F" modified="2009-09-22" version="1">MHIAVTGNIGAGKTTLTTMLAKHYGWDAQFEDVDHNPYLGDFYADMSKWSFALQIYFLGSRFRQVKEIRDSGKNIVQDRTIYEDAHIFAENLNDMSLMTDRDFNNYSAVFGLMKSFVSAPDLLIYLKSDVPNLVKKIYKRGREYEATISIEYLSKLNQKYEKWISGYQEGKLLIIEVDDLDFVEKPEDFGLILEKIETELHGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G3</accession>
    <name>C6X6G3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806286.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01554"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08001">
        <property type="protein sequence ID" value="ACU08001"/>
        <property type="gene ID" value="FIC_01554"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01554"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_0_5_10"/>
    <dbReference type="OMA" id="DACAPFL"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="32416" checksum="4F08FABEE9633132" modified="2009-09-22" version="1">MKLSIIIVHYNVAKLLRNCLISIQKYTQDIELEVIVIDNLSPDPAWLDLKGEFPSVKFIASTQNGGFAVANNRGVELAQGEYILLLNPDTEFEGFYLKEILDFAGQQNSFGCLGVRMHDLSGQFLPESKRSVPDMVNSFEKLFTGFRKNNAKSYYRNDIGEFEVAEVEVLTGAFLLMNRNVYLEVGGLDEKYFMYGEDIDLCYTVLNKGYTNWYYGKASILHHKGESTVKNDVYLQRFYGAMQIFLDKYYGKQKPLQYAVLSAGLHVRHLIEKYRQKKKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-07-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B3GGB1</accession>
    <name>B3GGB1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ice-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00493</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5 7">3519-10</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2009-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Christner B.C."/>
                <person name="Raymond J.A."/>
                <person name="Schuster S.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">3519-10</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2017" name="PLoS ONE" volume="12" first="e0187169" last="e0187169">
            <title>Structural basis of antifreeze activity of a bacterial multi-domain antifreeze protein.</title>
            <authorList>
                <person name="Wang C."/>
                <person name="Pakhomova S."/>
                <person name="Newcomer M.E."/>
                <person name="Christner B.C."/>
                <person name="Luo B.H."/>
            </authorList>
            <dbReference type="PubMed" id="29108002"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0187169"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 23-533</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ice-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="EU694412">
        <property type="protein sequence ID" value="ACD76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782099.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="PDB" id="5UYT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.75 A"/>
        <property type="chains" value="A/B=23-533"/>
    </dbReference>
    <dbReference type="PDBsum" id="5UYT"/>
    <dbReference type="SMR" id="B3GGB1"/>
    <dbReference type="STRING" id="531844.FIC_00493"/>
    <dbReference type="EnsemblBacteria" id="ACU06952">
        <property type="protein sequence ID" value="ACU06952"/>
        <property type="gene ID" value="FIC_00493"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00493"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510696_0_0_10"/>
    <dbReference type="OrthoDB" id="523713at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021884">
        <property type="entry name" value="Ice-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11999">
        <property type="entry name" value="Ice_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011935044" evidence="3">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="4">
        <location>
            <begin position="461"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="244"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACD76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="5UYT"/>
        </source>
    </evidence>
    <sequence length="533" mass="54125" checksum="8A96FDD008B72775" modified="2008-07-22" version="1">MNKFLLLAASVAFMSFSGKAHAQAPTLGAAANFALFTTAGAVTNTGLSHITGDVGTNNAASTNFGNVDGVMQDSNGATSAAAADLLIAYNLLNAAIPTATLAPLLGNGTTLTAGNYFIGQGASLSGTLTLDGGGNSNSVFIFKIQGALSSAANTQVLLTNGALACNVFWKVEGLVDLATNTVMKGNVVANNAAIVLQSGVSLEGRALSTTGAITVTGVTVRKPILCGSAVLTGPVAPNLGTVVCYTIFSGNGALTNAGITYVTGDVGTNVGLTTGFQADNVNGTIHSNPDTSTAQAALDLNNAYTYLNTLPTDIELLYPAAFGQNLVLTPHTYLLNAATVLNGKVTLDAQGNENAVFVIKINGALSTTVNASVELINGAIAKNVFWKVDGAVDLNDYTKFKGSVIGNNGAVIINTGVEIEGRVLSTSGGISTFGINAQMTPGCELLGTGSNTVAIQAAKFYPNPFSSVLNVTMEDLNGGSTLTIYNAAGSQVFSKVLSTKTTSLSMKLPAGVYFYQMIGKNGAKQAGKLIAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD3</accession>
    <name>C6WZD3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rny</name>
        <name evidence="8" type="ordered locus">FIC_00518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782123.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00518"/>
    <dbReference type="EnsemblBacteria" id="ACU06976">
        <property type="protein sequence ID" value="ACU06976"/>
        <property type="gene ID" value="FIC_00518"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00518"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_10"/>
    <dbReference type="OMA" id="PHAILGM"/>
    <dbReference type="OrthoDB" id="1012190at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="340"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="524" mass="58516" checksum="4D7E836A63828986" modified="2009-09-22" version="1">MTTTVAIIIGIVCLIAGAAIGMLFSKSSLNTKAKFILDDARKNAENLLDKANVQAESIRKEKQLQAKEKFLELKSQHDADIQSREKKMQETEKRIKDKESKLNDELSKAGKLEKELERKIGDYNKKHEIIEKKQQELEVATAQKVEMLEKIANYSAEDARNELVEAMKSEAKTRAQAHVQSIMEEASLNAKQEAKKIVIQTIQRIGTEQAIENSVSVFNIESDEVKGRIIGREGRNIRALEAATGVEIIVDDTPEAILLSCFDPVRREIARLSLHRLVTDGRIHPARIEEVVEKTKKQIEEEIIEVGKRTVIDLGVHGLHPELVKIVGRMKFRSSYGQNLLQHSREVANIAATMAAELGLNVKLAKRAGLLHDIGKVPEQESELPHALLGMQWAERYGENPEVINAIGAHHDEVEMTSLLSPIIQVADAISGARPGARRQVLESYIQRLKDLEAAALSFDGVSSAYAIQAGRELRVMVESSRVNDDQSSQLSYDISEKIQNELTYPGQVRVTVIRETRSVNIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI6</accession>
    <name>C6WZI6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrD</name>
        <name evidence="13" type="ordered locus">FIC_00045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781668.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00045"/>
    <dbReference type="EnsemblBacteria" id="ACU06521">
        <property type="protein sequence ID" value="ACU06521"/>
        <property type="gene ID" value="FIC_00045"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00045"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_2_0_10"/>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="46"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="112"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU06521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="335" mass="37550" checksum="E9BB00E9EA3677FE" modified="2009-09-22" version="1">MYKSIIRPVLFKFDPEKVHYFTFSILKRFPFLKNIIAPKPLHDKRLEREVFGLKFKNPVGLAAGFDKDAKMFTELSDLGFGFVEIGTVTPKPQDGNPKKRLFRLKEDSAIINRMGFNNGGVDAAVERLKKNKHVLIGGNIGKNKLTPNEDAVNDYVMCFEKLFPFVDYFVVNVSSPNTPNLRELQEKEPLTKLLGTLQQLNSQKEKPRPILLKIAPDLSDDQLLDIIDIVKETHIAGVIATNTTLSRENLVSEDRNETGGLSGKPLTERSTEVIRFLSEKSGKAFPIIGVGGIHSADDALEKLDAGASLLQLYTGFIYEGPQLIREINERLLARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK6</accession>
    <name>C6WZK6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781688.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00065"/>
    <dbReference type="EnsemblBacteria" id="ACU06541">
        <property type="protein sequence ID" value="ACU06541"/>
        <property type="gene ID" value="FIC_00065"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00065"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_10"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="320"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="549" mass="61824" checksum="B17267F0E18CD00A" modified="2009-09-22" version="1">MLSRIFIQNFALIDSLEITLNKGLQVITGETGAGKSIILGALRLILGERADTKTLQNTETKSVVEAEFAVSDQFRNFFEENDLDFDTQTIIRREVLPNGKSRAFINDVPVTLETLRGLSSKLIDIHSQFESSNLFSDEYQFKIVDGLSKNKALIINYQKEFSEYKKLLRDLETAKKQLAENNKESDYKTFLLDELLEANLDQVDLDELQNQVKKQENAESITENLAQIFAKLDAEEIGVLDSMNEVKTKLAKVADLSHEFSLLNQRFQENFLEFKDIVFELHDEAEAMETNPEILFELNRTLNSVNSLMLKHSVNSVDGLKEIRDQIESEQHSFTQLETTITDLERKIGTAHNRLEKMAAELSSNRKKSVPVFVKKVEALLKQLGLEKAKIEVELNDTAEFNIFGREQIQLLFQANSGFALKPIQSAISGGERSRVMLSIKKLMAENAELPTLILDEIDTGVSGRVAEEMGNVMKEMSGDMQLIVITHLAQVAAKGNNNYKVIKEEVSGKTQSNIIPLSQEEKLQEIAQLLSGSRITDAAVSQAKELMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL7</accession>
    <name>C6WZL7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00076"/>
    <dbReference type="EnsemblBacteria" id="ACU06552">
        <property type="protein sequence ID" value="ACU06552"/>
        <property type="gene ID" value="FIC_00076"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00076"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_13_2_10"/>
    <dbReference type="OMA" id="VALRLWF"/>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="124" mass="13195" checksum="C3DC6833C0BBC473" modified="2009-09-22" version="1">MKMDATVIIGLMILGLFAGYLSGMVGIGGGIVMVPVLVLLFGFTQHRAQGTTLALLIFPVGILGVMNYYKTGNVDLKTTLLLCVGFVLGSYLGSKTAIAVSQETLRKVFAFLLVAVAAKMFFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM8</accession>
    <name>C6WZM8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF853 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781710.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00087"/>
    <dbReference type="EnsemblBacteria" id="ACU06563">
        <property type="protein sequence ID" value="ACU06563"/>
        <property type="gene ID" value="FIC_00087"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00087"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028164_2_0_10"/>
    <dbReference type="OMA" id="TTEYGNI"/>
    <dbReference type="OrthoDB" id="600220at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="1">
        <location>
            <begin position="36"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="508" mass="55972" checksum="06C3A7BAEC59E411" modified="2009-09-22" version="1">MPDKARFIDELSARYKAKGEYITLGKAMLDGEVVTEIDVTIPLKTINRHGLIAGATGTGKTKTLQVFAEQLSHLGIPSLVLDIKGDFSGIAEPGEQNPMIAERYAKTQLPYEPQAFPVELMTISGEKGVKLRATVTEFGPLLLSKILDLNDTQQSIISIIFKYCDDKGLPLSDLEDLKKVLKYVTDNPQGKADLINNYGSIAPASLGAILRSIVALEQQGAAGFFGEPSFDVEDLLAQRDGKGVVNILRVQNLQSRPQLFSTFMLSLFAEIYMTFPEEGDSGKPKLVLFIDEAHLIFKEASKTLLNQIETMVKLIRSKGVGIYFITQVPGDVPENVLSQLGLKIQHALRGFTAKDRKEISQAVDNYPVTEYYKADELIQNLGIGEAFITALDEKGIPTPLVHTFLISPESRMDVLNDSEVEELTRRSGLVAKYEQALNKDSAYEMLTSRMEQAVQNAAPTQKARPVKEEPGMFESVMKSRAGRTFTTTLAREGAKFVLGMFGLGGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ0</accession>
    <name>C6WZQ0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781732.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00110"/>
    <dbReference type="EnsemblBacteria" id="ACU06585">
        <property type="protein sequence ID" value="ACU06585"/>
        <property type="gene ID" value="FIC_00110"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00110"/>
    <dbReference type="eggNOG" id="ENOG5030WFP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119542_0_0_10"/>
    <dbReference type="OMA" id="NADKTDH"/>
    <dbReference type="OrthoDB" id="1573288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973273" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="20799" checksum="291753DC544E6212" modified="2009-09-22" version="1">MKKLLLLAAVISGTMSYQAQETAPENVRQNDVMISPIELIAIPLLNVSYERLINENSGVGINGMFYFGDDNADNFDEDDSSMTQISPYYRMYFGRKYASGFFVEGFVPITMTTDYYYYFNSPDPSQVIDKRTTIGIGVGFGGKWVARKNIIFEASMGIARRFGEAKYYDSSNITGKGMLGIGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU3</accession>
    <name>C6WZU3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Big_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781775.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00153"/>
    <dbReference type="EnsemblBacteria" id="ACU06628">
        <property type="protein sequence ID" value="ACU06628"/>
        <property type="gene ID" value="FIC_00153"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00153"/>
    <dbReference type="eggNOG" id="COG4704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014237_1_0_10"/>
    <dbReference type="OMA" id="YTHFLPD"/>
    <dbReference type="OrthoDB" id="1565065at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973279" description="Big_5 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="558" mass="63531" checksum="7D2FCB5125837F7C" modified="2009-09-22" version="1">MKKIIFLFLLNFVLFSCARVGSPVGGDRDTIPPNVIGTNIDTSRVNVPRDIRELRIDFDEYITLKEINKQLIISPPLAKMTKIIPSGMANKYLLIKWDDTLQANTTYNFNFGNAIQDNNEGNALQYFNFAFSTGEKIDDLYISGEVKSVIADENAKEDANLVVGLYRHKDSMDYRQKPYYITKADPDGYFELNYLSPGNYRILAFEDSNSNSVYDPGNERVGFLKDSLVLDKSISGLNINLYPSRKAVKYTEMKETPGGILMTFEGNPQTVKVLSLNEKIQDYKITHRPKSDSVHIWFDALKLNVGTTASENLRFSYDDGIKQDTVSLFYRHNAKNEMTVSNAKGNLLAPNDDFIITSNYFIDRIQPEKWSLVSDSVSQEFTAKISDANPFQIQIQSAFKEGKKYSLTVPKETVSSYYEAIIKSYRFDFESDKTENFGSLAVTLENAPTQNFWFQLLSENGKILYSRFGKSEIITFNSLKPAKYRLRILVDNNENGIWDSADLASEEFAEDVFVLDKTIEVRPLWEIRETWNLNTTTPETPGTSQPEDQTPAELTEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV6</accession>
    <name>C6WZV6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxycytidylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00166"/>
    <dbReference type="EnsemblBacteria" id="ACU06641">
        <property type="protein sequence ID" value="ACU06641"/>
        <property type="gene ID" value="FIC_00166"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00166"/>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_2_2_10"/>
    <dbReference type="OMA" id="TKWYVLH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="141" mass="15742" checksum="A47E161620DCB839" modified="2009-09-22" version="1">MEPTKFDFAYLKMAMEWAKLSHCERRKVGALIVKDRMIISDGYNGTPSGFENCCEDSEGKTHWYVLHAEANAILKLAGSTQSAKDATLYLTLSPCRDCSKLAVQAGIKKVVYMDDYSDNAGITFLQDHGIEILKISKEQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY0</accession>
    <name>C6WZY0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase</fullName>
            <ecNumber evidence="7">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00190"/>
    <dbReference type="EnsemblBacteria" id="ACU06665">
        <property type="protein sequence ID" value="ACU06665"/>
        <property type="gene ID" value="FIC_00190"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00190"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_1_1_10"/>
    <dbReference type="OMA" id="WRLLGHF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="376" mass="42198" checksum="464A560C7941B161" modified="2009-09-22" version="1">MVNTMDEIKNILNDAGIPQFYLKLGFGMLFSFLLTFFSVPTIVKISRRKNLMDEPGVRSSHLRKIPNLGGIAMFYSIAVCASVFAFELFDIYKFLFASLVILLYIGVMDDIVIMRAYKKLLAQIIVTALMVIGSDVRLRSFFGLFGVYELNYFFSCAISIFTFIVLINAFNLIDGIDGLAGGYSILCSAMFGISYFRLGEYNYPLVVLSGVIIASVAGFLYYNLTGFRNMKIFMGDTGSMILGFLLAFTAICFIDIFIDKELAGVPRYYLQSAPAVAMAILILPIVDTLNVFIIRIYEGRSPFIADRNHIHHALLNLGLSHRKSTFYILMYYLGVVAVAYYFRHININILLAVIIALGFVGAYLPKAILLIRKQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X005</accession>
    <name>C6X005_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="2">2.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781837.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00216"/>
    <dbReference type="EnsemblBacteria" id="ACU06690">
        <property type="protein sequence ID" value="ACU06690"/>
        <property type="gene ID" value="FIC_00216"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00216"/>
    <dbReference type="eggNOG" id="COG0813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_2_0_10"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="235" mass="25979" checksum="E205135396E9C93A" modified="2009-09-22" version="1">MSVHIAAKKGEIAKTVLQPGDPLRAKYIAENFLENIRLVSQTRNIFYYTGLYKGKEISVGASGMGVPSIGIYSYELYTEYDVETIIRIGTCGAYTPELKIFDVLNVENAASESTYAKFAWEIEEEILSSQGNTFAVINDTARNLSRELKTTNIHTSDIFYRKNPGTPLIAEKYNCTAVEMEAFALFANAQYLGKNAATLLTVSDIIPTGEFISADQRETALTPMIELALETAINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X038</accession>
    <name>C6X038_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yidC</name>
        <name evidence="16" type="ordered locus">FIC_00250</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781870.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00250"/>
    <dbReference type="EnsemblBacteria" id="ACU06723">
        <property type="protein sequence ID" value="ACU06723"/>
        <property type="gene ID" value="FIC_00250"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00250"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016535_2_0_10"/>
    <dbReference type="OMA" id="WGIFGWI"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="15">
        <location>
            <begin position="77"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU06723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="604" mass="69290" checksum="D9B40807847C12C5" modified="2009-09-22" version="1">MQQNNGLDKNQLISFALFSLILIGAMFYFQNKQATEQQLINAQNPAQTASAATAPATKPAVITNLNDSLKTTSIQQVQLKNKELTLSVSSLGGQISTVQLNEYKAYNRKTDANDKELLLFDKNNSTYGFQFKDKTGKTFNTKDLVFTPTQNGNTVTMQANVNGAVIQFIYTLLDKYTVDFNVKTQGLSQLVSDQKATFVWDFNAREMEKGRSQEQTHTEFNYSFDNYSSFDYDGRTSMEEPDETLNWLAIKQQFFSAVIEPQTGFKNSVGSQEMIDEGEFLKTFNFNGQVDLAGNELNQNFKWYFMPLDLPLLKSYDKNFDELLPLGWSFIGTMNRWFFIPMYNLISSWGIAAGWVIFLMTIIVKIILSPVMFKQHKLSAMMRVIRPEIDEVNAKYKDADPMKKQQETMAVYRKAGVNQMAGCLPALLQIPIFYALFRFFPNMIDLRGKSFWFAKDLTAYDDVIKLPFNIPFLGEHLSIFAIACTVVILIYTVMTSGNIQQPQQEGMPNMKVLMYIFPITFLFFLNTGASGLSWYYFVSNAINILIILVIKYWILDEKKIHATIQANKQKEPKKEGKFQKRMREMMEKAQEQQKAQQHQAGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X043</accession>
    <name>C6X043_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.14" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781875.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00255"/>
    <dbReference type="EnsemblBacteria" id="ACU06728">
        <property type="protein sequence ID" value="ACU06728"/>
        <property type="gene ID" value="FIC_00255"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00255"/>
    <dbReference type="eggNOG" id="COG3124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099370_1_1_10"/>
    <dbReference type="OMA" id="MNFLAHI"/>
    <dbReference type="OrthoDB" id="1398998at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008770">
        <property type="term" value="F:[acyl-carrier-protein] phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007431">
        <property type="entry name" value="ACP_PD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38764">
        <property type="entry name" value="PTHR38764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04336">
        <property type="entry name" value="ACP_PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="192" mass="22612" checksum="4BBA03E96F468E0F" modified="2009-09-22" version="1">MNFLAHSFLTFTDEQIVGQFLEDFIRNKDRFSYPAKIGEGITLHREIDTFTDAHPEIREAKKIFSPLVRLYSGAFVDVSFDYFLARSIGYKELFAHSQRVYRVLRKHQDIFPPNFLRMLDGMEKDNWLYHYKDESGIGFSFRNVLHKAKYLDKNLAVFEVFLSNKTALEQHYNNFFPDLLSHAKTVNAGFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X061</accession>
    <name>C6X061_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="7" type="ordered locus">FIC_00278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781893.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00278"/>
    <dbReference type="EnsemblBacteria" id="ACU06746">
        <property type="protein sequence ID" value="ACU06746"/>
        <property type="gene ID" value="FIC_00278"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00278"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_3_0_10"/>
    <dbReference type="OMA" id="CFKAGIK"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="194" mass="21076" checksum="176DC3C0599F8835" modified="2009-09-22" version="1">MTKEDKVLVIQELKDLLQDAKVVYVANLEGMNAAATSDFRRQAFKQNISLKVVKNTLLQKAMEQIEGVDYSEMFESFKGNSALMISETANAPAKLIQNFRKKAEIPALKSAYLQETVYVGDENLGTLANIKSREEMIGEIIGLLQSPIQRVVSALQNKEEATGKAEEAAPAEETPAAEAAPEASAEATEAPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X067</accession>
    <name>C6X067_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="7">DHBP synthase</shortName>
            <ecNumber evidence="7">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribB</name>
        <name evidence="9" type="ordered locus">FIC_00284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00284"/>
    <dbReference type="EnsemblBacteria" id="ACU06752">
        <property type="protein sequence ID" value="ACU06752"/>
        <property type="gene ID" value="FIC_00284"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00284"/>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_1_2_10"/>
    <dbReference type="OMA" id="ECRGLIC"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="8">
        <location>
            <begin position="255"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="7">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="7">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="416" mass="46355" checksum="8E969F1843B620E5" modified="2009-09-22" version="1">MSGALFVTRSGAKKRERKTDEDAQIKVGEYLNLSIFAPFKKSNMSDIQLNTIPEAIQDLKDGKIIIVVDDENRENEGDFLSAAELTTPEIINFMTLYGRGLICTPLPEKRCDELGLDIMVTRSSDPKETAFTVSVDLLGEGVSTGISASDRSKTILALMDENTKPADFMRPGHIFPLRAKKGGVLKRAGHTEAAIDLTKLAGLKEGGVICEIMNEDGSMSRLPELVELAKKHDLKIISIEDLIHYQLKKGDLIERIEERKVKTHYGDFDFFAFKETSTDQIHFALTKGTWVVDEPVLVRVQASNAYFDVLSRLTAGEKPLLEKVTNMINEEGKGALIFINNVSTAENTLRKLQQFIDFQDGQEKRPTLASNFHDYGIGTQILKNLGITKFRVITQNVNQKPLVGGYDVEVTEMVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E0</accession>
    <name>C6X0E0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781972.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00358"/>
    <dbReference type="EnsemblBacteria" id="ACU06825">
        <property type="protein sequence ID" value="ACU06825"/>
        <property type="gene ID" value="FIC_00358"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00358"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147365_1_0_10"/>
    <dbReference type="OMA" id="NTFHEGA"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="136" mass="15991" checksum="A655C9EB9B1BBECF" modified="2009-09-22" version="1">MEQKIHQGRNVKRFREMLGIKQEALAFDLGEDWNQKKISLLEQKEVVEDPLLRKIADVLKIPVEAFQNFDEEQAVNIIANTFHEGAIANNSGYIHCTFNPLDKLVQLHEEKIILYERMLKEKDEMMTRLEKVIQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K7</accession>
    <name>C6X0K7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00431"/>
    <dbReference type="EnsemblBacteria" id="ACU06893">
        <property type="protein sequence ID" value="ACU06893"/>
        <property type="gene ID" value="FIC_00431"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00431"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063038_0_0_10"/>
    <dbReference type="OMA" id="NSGYWNP"/>
    <dbReference type="OrthoDB" id="620166at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="361" mass="39575" checksum="9DCD24404FD69473" modified="2009-09-22" version="1">MMKNIFLALLIFSGIFSEAQIVRKYSNEFLNIGAGARGLAMGGAVLSSQNDVYSPMWNPAGLIGVDRDWQGAAMHAEYFESIAKYDYLAFAKPLDNNGGVFAISLVRLGVDNILNTTQLIDSEGNIDYDKITSFSQSDYAALISYAFRPGGNHRLAVGVNAKLVYRNVGKFASGYGFGFDLGALYNSDSGWNYGAMLRDATTTVNFWTINQDELSTVVNGEEFNPAPADKLEITMPKLNLGVSRNFEINRDLELTPEAGLNIDFAKTAALISTDFASITPYAGAELRFQDMIFVRVGVNRFQTITDIEDLKRNVSFQPSAGIGIKYQGLTLDYAITNSGVGGSNFFSNFFSLKLDMGDFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L2</accession>
    <name>C6X0L2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LigB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782045.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00436"/>
    <dbReference type="EnsemblBacteria" id="ACU06898">
        <property type="protein sequence ID" value="ACU06898"/>
        <property type="gene ID" value="FIC_00436"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00436"/>
    <dbReference type="eggNOG" id="COG3384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_2_0_10"/>
    <dbReference type="OMA" id="RTEHFAP"/>
    <dbReference type="OrthoDB" id="1728007at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="275" mass="31193" checksum="0A6B04500E0AEFA9" modified="2009-09-22" version="1">MNLNDLENITHQFKNTQKMPVLFLGHGSPMNAIEENQFVQGFRDVSKEIPKPTAILCVSAHWFTKGTFVTAMEMPRTIHDFYGFPEELFAVDYPAPGNPDLAELTAELLAPSPVEENHNWGLDHGAWSVIKHLYPNADIPVIQLSIDYTKPPQYHFDLAKRLQKLREKGVLIIGSGNIIHNLRMVDFRNINTVGYGYDWAHEAREKSNNWLLDGDFKQLIDYEKQGIFMHAAVPTPDHYLPLIYSLGLKEKSEELSLFNDELIGGSLSMTSVKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M2</accession>
    <name>C6X0M2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-binding proteins-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782055.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00446"/>
    <dbReference type="EnsemblBacteria" id="ACU06908">
        <property type="protein sequence ID" value="ACU06908"/>
        <property type="gene ID" value="FIC_00446"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00446"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_2_10"/>
    <dbReference type="OMA" id="NSELLYI"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="23595" checksum="2CCBA112CE747F5C" modified="2009-09-22" version="1">MINTFQALIDFAKLKFSFTPEDEKLIAQYFEQQLFGKNEIILNAGDVCNKIYFIKKGSVRTFHVNKNGSEFTRLIATENEFCTILISFLEKIASPASIQAMEKTEVLVIDRNAFRDFIEVSPNAEKMYTKILEDFQNFQIKMLEFLTSFSPQEKVDLFLKENPDLEARLTDKVIASYLQITPETFSRCKNKRLQEYLLKIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0T6</accession>
    <name>C6X0T6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ordered locus">FIC_01603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01603"/>
    <dbReference type="EnsemblBacteria" id="ACU08049">
        <property type="protein sequence ID" value="ACU08049"/>
        <property type="gene ID" value="FIC_01603"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01603"/>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_3_2_10"/>
    <dbReference type="OMA" id="EMSFLDH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="273" mass="31359" checksum="3DE73EB9BC0B3855" modified="2009-09-22" version="1">MVEKKEMSFWGHIGELRGHLIRSLIAIVLGAVVVGLNVNWIMDHVFFGPTKNDFFTFRVVNHYSRELLGYDSIILPDHFAVQQKKLFQQFNVMMSVSIFGGMVVAFPYIVWELWRFISPALHPSERKNSVFLINFVWILFLVGILVGYFLILPFAINFGLLFTISDSITQLFDLSDYTTLFMQVVLGMGIIFLFPVIVYFLTSIGILTPTFMRTYRRHAIVLIMVVAAIITPADVLSMLMAAFPLLLLYEFSIMMCAYTFKKVQLRDQLPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0V0</accession>
    <name>C6X0V0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806348.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01617"/>
    <dbReference type="EnsemblBacteria" id="ACU08063">
        <property type="protein sequence ID" value="ACU08063"/>
        <property type="gene ID" value="FIC_01617"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01617"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025776_1_0_10"/>
    <dbReference type="OMA" id="ANYYYAN"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="64"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="348" mass="39708" checksum="7265D142F46196E0" modified="2009-09-22" version="1">MKWQFLLVFTVFSLICCKKEQQVNPAKWEKISHHVQIQPYPDGFKLRSGKFTYNISASTLPYKKVILLNASLVGYFTELGLENKIIGISSPEYIYSQKVKDLISSGVIQNIGNEQKYDVEKIIALKPDVIFTNYVASFDNTYDLVRKNGVEIIFLDEYLEQNPLEKSKYLLVFGKLLGNYEGAASRFNEIRASYDFLKNLSKKEATKPVVLANEMYGNQWFLPGGQSNLATFIADANAQYINAENPDSKAVPVSFEEVFAKAESAEFWVNVGNHRSKKELLQINPNYAKMNVYNNGKLFTVSGRERGKSNDYFESGVVRADLVLTDYIRIFHPDLLPNYQLTYLKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X117</accession>
    <name>C6X117_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806415.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01687"/>
    <dbReference type="EnsemblBacteria" id="ACU08130">
        <property type="protein sequence ID" value="ACU08130"/>
        <property type="gene ID" value="FIC_01687"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01687"/>
    <dbReference type="eggNOG" id="COG2388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132888_2_1_10"/>
    <dbReference type="OMA" id="KHEFDTT"/>
    <dbReference type="OrthoDB" id="1872172at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="94" mass="10343" checksum="4F0449872E94E082" modified="2009-09-22" version="1">MAEIKHVESSTKGSFDIYFEGEKAGSLTYTWAGEDKFIIDHTEVDPKFSGKGLAKDLVVAAVSYAREKGKKVIPLCTYANATIRKNTELQDVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X140</accession>
    <name>C6X140_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hyaluronan synthase</fullName>
            <ecNumber evidence="3">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.212" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806438.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01710"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08153">
        <property type="protein sequence ID" value="ACU08153"/>
        <property type="gene ID" value="FIC_01710"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01710"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029695_4_2_10"/>
    <dbReference type="OMA" id="YKMFIRW"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="111"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="461" mass="52961" checksum="B8C5754BCFC69C5F" modified="2009-09-22" version="1">MKNSILQHKLPFPTRRIGFIARLKSLNKKEYGVLIGAQILMFSAIYAVNNFHPYFEELHFQRMETLPGRILVYFLLTALVFQVSFLLYIAFLFVRYRPVEGVADSELPTCTVIVPAFNEGSLVYDTLKSIAASGFPAHKMQIIAIDDGSTDDTWHWIVKANKDLNNSITIWQQPENKGKRHALYHGFTTGSGEVFITIDSDSVVKPDTIRNLVSPFVVNENCGAVAGNVKVLNRNQGMIPRMLNVSFVFSFEFMRAAESSLGFVLCTPGALSAYRRDSVLNCLDEWINQKFMGKFATIGEDRAMTNLILEQGRDVQFQRNATVLTNTPVGYKTLHKMFTRWGRSNVRETLMMNRFMFKRFRENNRGGARFIYLHQWMKLVMAYPLMLLMFWFLFTHPLLYVSSALTGTFVFSSIQMLFFSRKYPVGEALWAYPYSVLYLFGLFWIFPFAIATVKNGGWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X141</accession>
    <name>C6X141_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component hybrid sensor and regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806439.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01711"/>
    <dbReference type="EnsemblBacteria" id="ACU08154">
        <property type="protein sequence ID" value="ACU08154"/>
        <property type="gene ID" value="FIC_01711"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01711"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_10"/>
    <dbReference type="OMA" id="QMANSCD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="371" mass="42058" checksum="732C86F41C964C33" modified="2009-09-22" version="1">MILIVDDSPQNIISLKKVLEKNDFEVDTASSGEEALKKILKKSYVLIILDVQMPGMDGFEVAEAISGYSRAKETAIIFLSAASANVSLITKGYSSGGLDYISKPVDMNILLLKVKTFYRIYEQSRALNEMQNALREEIEFRKEAERKKDEFISIASHELKTPMTSIKGYIQLLERSIEKNDIETTKIRLGKVQNQIEKLNLLVADLLDISKIESGKLKFNKKHFCYDEVLSHILEVMQQSNPHITIMKIGQVEDSVYADEMRIEQVIINFITNAIKYSPGSEEIHVLTEIQDGHIYCAVRDFGIGMSPEHQNKIFDKFYRIEETSERFQGLGIGLYICQEIIGRHEGTIGVKSTPGQGSEFYFTLPLTPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X162</accession>
    <name>C6X162_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xylosidase/arabinosidase</fullName>
            <ecNumber evidence="4">3.2.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01732"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08175">
        <property type="protein sequence ID" value="ACU08175"/>
        <property type="gene ID" value="FIC_01732"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01732"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_4_1_10"/>
    <dbReference type="OMA" id="YLFFPAR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="367" mass="42392" checksum="C85CE40FCEB31F8F" modified="2009-09-22" version="1">MISRLLAVQITRYCSTEIIRQNRSLKNLLNSTKRNKQNNSKNIKIMKKAKYLFPGDYMADPSVHVFEGKIYIYPSHDWESGVEENDNGDHFNMKDYHVFSMDDVETGEVTDNGVVLSVEDVPWAGRQLWDCDVAFKNGKYYMYFPMKDKNDIFRIGVAVSDRPYGPFVPEKHPMMGSYSIDPCVFEDEGKHYMYFGGIWGGQLQRYRNNKALECAILPEENEAAICPKIAVLQDDMLEFGEEPRDVKIVDQDGNELLHSNPHRFFEASWMHKHNGKYYFSYSTGDTHFLCYAIGDNPYGPFTYQGVILTPVVGWTTHHSIVEYKGKTWLFYHDAVPSGGKTWLRSMKVTELEYNEDGTFKTIEGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X174</accession>
    <name>C6X174_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylulose kinase</fullName>
            <ecNumber evidence="3">2.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806472.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01744"/>
    <dbReference type="EnsemblBacteria" id="ACU08187">
        <property type="protein sequence ID" value="ACU08187"/>
        <property type="gene ID" value="FIC_01744"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01744"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_10"/>
    <dbReference type="OMA" id="WHVMGVT"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="259"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="491" mass="53966" checksum="60FFAFBF2EB4FAA8" modified="2009-09-22" version="1">MYLLGYDIGSSSVKVSLIEASSGKIMATDFSPKKEMKIIATKPGWAEQNPADWWTNLKLAHESVMHHSSIDAEDVKAIGITWQMHGLILVDKDQNVLRPSIIWCDSRAVSYGEKAFETIGQEKCLSHLLNSPGNFTASKLAWVKENEPELFSKIDKIMLPGDYIAMKLSGEIGMTVEGLSEGIFWDFKNNCISKDVLDHYGIPESFFPEIIPTFGIQARVSREAAAELGLKEGTPISYRAGDQPNNALSLNVFNPGEIASTAGTSGVVYGVLDQLDYDQFSRVNTFAHVNHTAELTRLGVLLCINGTGSLNSWLKHNFATSLSTYGDMNELASLSPVGSKGLSIIPFGNGAERVLENSEVNCSIHGINFNIHSKGDILRAAQEGIVYSYEYGMDIMRNMKMKIEVIRAGNANMFLSSIFRQSLATVSNVVIELYDTDGSVGAARAAGMGIGFYADSGEAFASLEKIAVIEPEMEKREQYLESYHRWKSHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X189</accession>
    <name>C6X189_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806487.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01759"/>
    <dbReference type="EnsemblBacteria" id="ACU08202">
        <property type="protein sequence ID" value="ACU08202"/>
        <property type="gene ID" value="FIC_01759"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01759"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_13_1_10"/>
    <dbReference type="OMA" id="TTQVWQI"/>
    <dbReference type="OrthoDB" id="2060970at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="140" mass="15262" checksum="F5E361D1CFB35C0E" modified="2009-09-22" version="1">MDDTQQAEILHKLNNWGGENLGKTLGIIFTEVSAETLTATMPVTPKVHQPYGILHGGASCVLAETLGSCLSVIHVDTEKFAPVGTNINSNHLRSKRDGVVTGTARFIRKGKTMHVSEIEIRDENGELINHTTMTNNIISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P0</accession>
    <name>C6X1P0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ordered locus">FIC_01911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806638.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01911"/>
    <dbReference type="EnsemblBacteria" id="ACU08353">
        <property type="protein sequence ID" value="ACU08353"/>
        <property type="gene ID" value="FIC_01911"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01911"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_10"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="20878" checksum="07C5F91278AD85DD" modified="2009-09-22" version="1">MATSNDIKKGMCIEFSNDIFKIIEFMHVKPGKGPAFVRTKMKSVTNGKVLDNTFSAGHKIDEVKVITRKFQYLYEDDNGFHFMNNDDFSQIYLNKTMIENAQFMKAGEEVTIILKDADESPLSAEIPPTVYLDVIEADPGVKGNTATNALKNAIVETGARVMVPLFIEAGDKIKVNTEDGSYLERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q3</accession>
    <name>C6X1Q3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806651.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01924"/>
    <dbReference type="EnsemblBacteria" id="ACU08366">
        <property type="protein sequence ID" value="ACU08366"/>
        <property type="gene ID" value="FIC_01924"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01924"/>
    <dbReference type="eggNOG" id="ENOG502ZVT4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108410_0_0_10"/>
    <dbReference type="OMA" id="IYLRQRG"/>
    <dbReference type="OrthoDB" id="1532985at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="219" mass="25468" checksum="388772184DE22CB4" modified="2009-09-22" version="1">MKKFFYHNGLSIVFLSLFFVTFGGQIYFGIQEHNKDLAEWGGHQVNLWSYLKSGHFFEATFENWESEFLQMALFVWFTIFLRQKGSSESKKCDGETNEVDREPSPGREDAPWPVKKGGLWLQLYKNSLTYVLFLLFVLSFVLHIYGSFKDENTENLLQGKAPEKLEDYLLGSRLWFESFQNWQSEFLSIFAIIILSIFLRQKGSSQSKPVDAPHAETGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q5</accession>
    <name>C6X1Q5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="6" type="ordered locus">FIC_01926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806653.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01926"/>
    <dbReference type="EnsemblBacteria" id="ACU08368">
        <property type="protein sequence ID" value="ACU08368"/>
        <property type="gene ID" value="FIC_01926"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01926"/>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042923_7_2_10"/>
    <dbReference type="OMA" id="YNPNAMT"/>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPBB_1" evidence="5">
        <location>
            <begin position="33"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="123" mass="13727" checksum="9A52300B19352529" modified="2009-09-22" version="1">MMQRATLLIIMMISTLGIYSFNKYNASDSRTSMASYYHDKFNGRKTASGEIFHNTKLTAANRTLPFGTKLKVTNLRTGKSVIVKVNDRGPFHSSRALDLSKAAFDEIGNVARGTMPVEYEIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R2</accession>
    <name>C6X1R2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806660.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01933"/>
    <dbReference type="EnsemblBacteria" id="ACU08375">
        <property type="protein sequence ID" value="ACU08375"/>
        <property type="gene ID" value="FIC_01933"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01933"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_7_10"/>
    <dbReference type="OMA" id="KNSYIGT"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="33352" checksum="127027C38E7E2231" modified="2009-09-22" version="1">MNIIITGSTGFVGTNLSQYFEDNHYKVHRLSLRGDWSSLPDAHGLIHLAGRAHDTGSTCEAEEYYRINTHLTVRLFDDFLSSDIRDFFYFSSVKAAADSVEGELDEEYTPNPKTPYGQSKLMAEEYILSKPLPDNKRVYIIRPCMIHGPGNQGNLNLLYKVVEKGIPWPLAAFENKRSFLSIDNLNFLIDRMIHTDIPSGIYNFADDGYLSTNDLVQTIGKTIGKKALLLKIPTSMVSFAATIGDKLGLPLTTERLKKLTENYIVSNRKIKETLAVSDLPYSIEESLEKTIKSFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U1</accession>
    <name>C6X1U1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="8" type="ordered locus">FIC_01962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806689.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01962"/>
    <dbReference type="EnsemblBacteria" id="ACU08404">
        <property type="protein sequence ID" value="ACU08404"/>
        <property type="gene ID" value="FIC_01962"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01962"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_0_2_10"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="258" mass="28669" checksum="7CB4B3ABA74DCBB5" modified="2009-09-22" version="1">MAKANVKDLLEAGVHFGHMTRKWNPNMAPYIFMEKNGIHIVDLHKTAVKLDEACTALEKITSAGKKVLFVATKKQAKEVVAKYAADLNMPYITERWPGGMLTNFVTIRKAVKKMNQIDKMKKDGTFETLSKKERLQVDRQRANLEKNLGSISDMVRLPSAIFVVDIMKEHIAITEAKKLGIPIFAIVDTNSDPRKVDYVIPGNDDASKSIDMLLSIVSASIKDGLSQRKADKEKSKEEGEKVSADADTDFDTEATAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X221</accession>
    <name>C6X221_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine(34) hydroxylase</fullName>
            <ecNumber evidence="1">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA hydroxylation protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trhO</name>
        <name evidence="3" type="ordered locus">FIC_02042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:64224"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrhO family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806768.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02042"/>
    <dbReference type="EnsemblBacteria" id="ACU08484">
        <property type="protein sequence ID" value="ACU08484"/>
        <property type="gene ID" value="FIC_02042"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02042"/>
    <dbReference type="eggNOG" id="COG1054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038878_1_1_10"/>
    <dbReference type="OMA" id="VDFRNHY"/>
    <dbReference type="OrthoDB" id="684577at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="144"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="453" mass="51534" checksum="FD12B31BC854B6F4" modified="2009-09-22" version="1">MQLYNTLSAEERARLIDEAGKQRLTLSFYAYAKISDPKKFRDELFIAWNALDALGRIYVAHEGINAQMSIPADHFEAFRETLEVYDFMKGIRLNVAREHDDHSFLKLTIKVRNKIVADGLNDETFDVTNKGIHLKAKEFNTLLDDPDTIVVDFRNHYESEVGHFKGAITPDVETFRESLPIINEQLQDFKEDKNLLMYCTGGIRCEKASAYFKHQGFKNVFQLEGGIIEYARQIKEENIESKFIGKNFVFDHRLGERITDDVVSQCHQCGKPCDNHTNCFNDACHLLFIQCDDCKTAMENCCSVECLETIHLPLEEQAKLRKGLQVGNKIFKKGKSDALKFKNSGNLRDQPLAKANTKNIRQKIAVKKVLVGKAEHYYTKSKISQFLINSNGLSAGDKVLISGPTTGEQEFTIKEMFANGGPCETANKGDQITFETPFRIRLSDKIYKIVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X227</accession>
    <name>C6X227_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806774.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02048"/>
    <dbReference type="EnsemblBacteria" id="ACU08490">
        <property type="protein sequence ID" value="ACU08490"/>
        <property type="gene ID" value="FIC_02048"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02048"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_10"/>
    <dbReference type="OMA" id="MSEKVWF"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="262" mass="28948" checksum="0D02474BB6E92580" modified="2009-09-22" version="1">MTIIITGSSTGIGYTLAEHFGRLGHKVFGLSRKDAQSAYFTTIPTDITDNAQIQLAVAQVLDSTGQIDVLINNAGMGMVGAVEDSSQEEILKLFNLNLVGSVQMMSAVLPAMRSQRSGKIINISSIGSEMGLPFRGFYSASKSALDKVTEAIRYEVSQWNINVCSLHLGDIKTKIAENRIKTNVSAPYKNTFNKVHSLMNAHVDQGTESAEVAEYIGKLLARKSWKAHYYFGKFGQKIGVPLKWFLPQNVYENLMRKYNNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X280</accession>
    <name>C6X280_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806827.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02106"/>
    <dbReference type="EnsemblBacteria" id="ACU08543">
        <property type="protein sequence ID" value="ACU08543"/>
        <property type="gene ID" value="FIC_02106"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02106"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131484_0_0_10"/>
    <dbReference type="OMA" id="RTPEWVM"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="72"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="165" mass="17738" checksum="1DBF0320C29AB108" modified="2009-09-22" version="1">MKSLKAIALATLTFALFSCGDDKKTDSIPTASTTDAAATEAPAAGAADAAAYDPKRGLGPHENIDVSKFDPAMAASGKKIADVKCTSCHKTTEEKLVGPGWKGVTQRQTPEWIMNFISNPDPMIDVDPELQKQLELCLVRMPNQGLADNEAREVLEYMREIDGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C5</accession>
    <name>C6X2C5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806872.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02152"/>
    <dbReference type="EnsemblBacteria" id="ACU08588">
        <property type="protein sequence ID" value="ACU08588"/>
        <property type="gene ID" value="FIC_02152"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02152"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_10"/>
    <dbReference type="OMA" id="FVEICSH"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="450" mass="50157" checksum="150ACFF90683B4DB" modified="2009-09-22" version="1">MFKKILIANRGEIAMRILRTCKEMGIKTVAVYSTADKDSLHVRFADEAVCIGPPMSKDSYLKISNIIAAAEITNADAIHPGYGFLSENSNFSRICQENGIKFIGATPDQIDRMGDKANAKATMKEAGVPCVPGSEGLIDSYETAAKLAAEMGYPVMIKATAGGGGKGMRAVWKAEDLHEHWDSAVQEATAAFGNGGMYMEKLIVEPRHIEIQVAGDQYGKACHLSERDCSVQRRNQKLTEETPSPFMTDELREKMGAAAVKAAEYIKYEGVGTIEFLVDKDRNFYFMEMNTRIQVEHPITEQVVDYDLIREQILLASGSPISGKNYYPKLHSIECRINAEDPYNDFRPSPGKITGLNIPGGHGIRVDTHVYAGYSIPSNYDSMIAKLITTAQTRDEAIAKMRRALEEFYVEGVKTTIPFHRQLMEDENYLAGNYTTKFMEDFVMDRSYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F0</accession>
    <name>C6X2F0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2807 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02177"/>
    <dbReference type="EnsemblBacteria" id="ACU08613">
        <property type="protein sequence ID" value="ACU08613"/>
        <property type="gene ID" value="FIC_02177"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02177"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044832_0_0_10"/>
    <dbReference type="OMA" id="DKFTQDK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2807" evidence="2">
        <location>
            <begin position="108"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="324" mass="34278" checksum="5958E96DD3FF3032" modified="2009-09-22" version="1">MEDKLASGAGISVVEVSVFFIVVQAVFITNEEINKAEVIFFIFELLVKVKVLNLAKIKPTMKTLILSSAAAALLLSCNLKSENVFPSSLVAKEGKGTIKTKQFVMNIDEIKVAQSIRAEIVKSDIEKVVITAPEDIIDDILVDNDRGEVYIHFKPNFNISARNVAAKIFVKDFSKLEATSSAKIVVKDKFTQDKTDVEVSSSASISGNLETNDLSIDVSSSGDFSGEIWAVNLESQVSSSGDITISGKAKNAELHASSSGTLNAKNLVADDAVIKASSSGSVSAGVKNQLNASASSSGDISVAKKGNLNIVSQQQNSGGSISIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F5</accession>
    <name>C6X2F5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806902.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02182"/>
    <dbReference type="EnsemblBacteria" id="ACU08618">
        <property type="protein sequence ID" value="ACU08618"/>
        <property type="gene ID" value="FIC_02182"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02182"/>
    <dbReference type="eggNOG" id="ENOG502Z93E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121366_0_0_10"/>
    <dbReference type="OMA" id="KQQGYYN"/>
    <dbReference type="OrthoDB" id="1819955at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="21697" checksum="21BBE951234E8E66" modified="2009-09-22" version="1">MNKYIKFVIAALMIAGGIYLMMNRNIGWGVVVVILSALPILLFFKNEYILLAFWFLRKQNMAKAAKWLSKITNYPTQLHRSQFGYFHYLQGLTLAQESPQKMEPLMKKALEYGLNMKHDRAMATLNVAAGALQKGKRQEAVKLLEEAKRLDTAGMMTEQIKMMKDQLKMPSMQKHLHNPNMRNRGKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2I1</accession>
    <name>C6X2I1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806928.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02209"/>
    <dbReference type="EnsemblBacteria" id="ACU08644">
        <property type="protein sequence ID" value="ACU08644"/>
        <property type="gene ID" value="FIC_02209"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02209"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134960_1_0_10"/>
    <dbReference type="OMA" id="ISTHICS"/>
    <dbReference type="OrthoDB" id="1879806at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="14442" checksum="4547EDCB816A1945" modified="2009-09-22" version="1">MTENQISKVIFESGLKIHRKLGIGLYEAVYEECLVFELRNKGLKVEVQKDISIEYEGLRIPKAFRLDLLIEGKVIVEIKAVPEINSYHTFQLLNYLRITGCKLGMILNFHSLLFKNGVKRIANYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P7</accession>
    <name>C6X2P7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08710">
        <property type="protein sequence ID" value="ACU08710"/>
        <property type="gene ID" value="FIC_02277"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02277"/>
    <dbReference type="HOGENOM" id="CLU_1967289_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="127" mass="15099" checksum="DC4C5E6EDB23DD71" modified="2009-09-22" version="1">MLAPFPAFTTRFPHVRNSIRGVMLYENTKHFVELISAADIPADFEIFFRHFIESRLLIIFVGMRDINAVLFSKRYNRNKKYRDVASEDFHFRIHLKTVFIDFHGFLPDHFSGITCNEKHRYTLSLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U4</accession>
    <name>C6X2U4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807041.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02324"/>
    <dbReference type="EnsemblBacteria" id="ACU08757">
        <property type="protein sequence ID" value="ACU08757"/>
        <property type="gene ID" value="FIC_02324"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02324"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_3_0_10"/>
    <dbReference type="OMA" id="ELNPLYH"/>
    <dbReference type="OrthoDB" id="1543624at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="33"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="31727" checksum="758F5101253866A4" modified="2009-09-22" version="1">MTEPQQKWTETIESRHSLFDLKLGEVWRYKDLVYMFVKRDFISGFKQTVLGPVWFFINPIFTTIVYLVVFGNIANLSTDGAPKILFYLAGVTLWNYFSACLTGTSNVFVSNAGIFGKVYFPRLVMPLTIVISNLMRFGVQMALFIAAFLYYYFNGDVTPNLWILATPFLIILMAAFALGTGMIFSALTTKYRDIQMLLGFGISLFMYVTPVIYPLSALPPKLKTIASYNPLSGIFECFKYGWLGVGDFSAPLLLISSLIIFVLLAVGTVVFNKVEKGFMDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W1</accession>
    <name>C6X2W1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807058.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02341"/>
    <dbReference type="EnsemblBacteria" id="ACU08774">
        <property type="protein sequence ID" value="ACU08774"/>
        <property type="gene ID" value="FIC_02341"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02341"/>
    <dbReference type="eggNOG" id="ENOG503328R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182297_0_0_10"/>
    <dbReference type="OMA" id="CADDSVH"/>
    <dbReference type="OrthoDB" id="1887849at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="97" mass="10820" checksum="359CAD8F5B344D40" modified="2009-09-22" version="1">MKIWSIITLTVFLNFMALPSIAVAFGWDLPATNVVISEEESQHSPLIINEKTVPDTLNVHDFIKFFQADLNSQSFLCADDSVHLSPFLTIFSPPPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z2</accession>
    <name>C6X2Z2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein (Contains P-loop)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807089.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02372"/>
    <dbReference type="EnsemblBacteria" id="ACU08805">
        <property type="protein sequence ID" value="ACU08805"/>
        <property type="gene ID" value="FIC_02372"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02372"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059558_3_0_10"/>
    <dbReference type="OMA" id="ARANHRD"/>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="138" mass="15422" checksum="12BDC401B677D8F2" modified="2009-09-22" version="1">MSLTIEIHSFSYKKGGIPADPSGNGGGFTFDCRGILNPGRIEEYKAQTGCDLPVKEFLESQTDMPKFLELVKQIVSINIENYLGRNFENLQISFGCTGGQHRSVYCAEKIAAYIRETYPQATVLLQHDEQPQLNRAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z6</accession>
    <name>C6X2Z6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807093.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02376"/>
    <dbReference type="EnsemblBacteria" id="ACU08809">
        <property type="protein sequence ID" value="ACU08809"/>
        <property type="gene ID" value="FIC_02376"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02376"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401570_0_0_10"/>
    <dbReference type="OMA" id="ENPTQGF"/>
    <dbReference type="OrthoDB" id="1188070at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043744">
        <property type="entry name" value="DUF5689"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18942">
        <property type="entry name" value="DUF5689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5689" evidence="1">
        <location>
            <begin position="44"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5689" evidence="1">
        <location>
            <begin position="300"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="685" mass="74677" checksum="0F4239CE1B961482" modified="2009-09-22" version="1">MKNYLSFFKISFVMFASLVLTGCVHDDKYNDPDLTNYGCVELVKTKTLQEVKALYTGTTYVFPENTTDVIEGYVSSSDETGNIYKTIYIQDARENPTQGFVISVDAVSTYARFPQGSKIFIKLNGLAIGTYGGLVQLGVKDPAAGAATNGVARIPEKMIPTNIFKSCEAAAPIVPKVMTLADMNASNDKYLGCLIQIPNAEFDVKALCSVFAPAGTSVDRQLNDPTTSATTRVVRNSGFASFANQMLPAGRGTFIGIFSKFNASYQMYINKLADLADMRNFPRKDGITSDPCVLNESALTVKTVAEVKQLYTGALGQINGDYLLKAKVTANDETGNLFKYIYVEDATGAIRININKNDLFQDERFKVGKELYIKLKGLYTGANAGEIQLGVPFNGNIGQVLEVDVYKHFFDSKKPATAVVPTERTITQLTTADVGRWVKIKNVQFADADLGKPYASGSPTNRNIEDCQGNKIILRTSHFATFAGAEIDGGKGDLYAIVSIFNGVYQLWIPFQYNADFDDPRCDGTVPATFTSIFTDGFDTLANWTAVNVAGTQVWATTTFGNPRPSAIMDGNRVVNEDWLVSKKITITGFTDAYVSFETDGRFTGNPLELYVTENYTGTVGTTSWTKLNAALDTDLNGFSGFVGSGRVSLKSYLNKEVVFAFKYTSVAGSSTTWEVDNFAVKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z8</accession>
    <name>C6X2Z8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02378"/>
    <dbReference type="EnsemblBacteria" id="ACU08811">
        <property type="protein sequence ID" value="ACU08811"/>
        <property type="gene ID" value="FIC_02378"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02378"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058239_1_0_10"/>
    <dbReference type="OMA" id="KGYPFRS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19580">
        <property type="entry name" value="Exo_endo_phos_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="426" mass="48395" checksum="BD052B6A02FE1A8C" modified="2009-09-22" version="1">MFWFNYIRAPSKLLVILQPIKIYSNFQMKKHLILIAIFSFAFVFAQQRQVQRATVAFLNVENLWDTIPSADYIDGTKDIHNPAFHRSVPLDSLKFLETTEEYRGEWNDENVIGKKVIRHQILADDFTVNSSKNWNTDKYTQKLTNIARVISELGRQYTNDNPAIVGLLEVENRQVVEDIIKQPVLAKSNYGIVHYNSYDARGIDIALLYQKSRLKVTETYDKEVKIFNAEGKRSYTRGVLVVKGFLDGEPVGIFLNHWPSRSGGEAATVARRAAAATVLKQEMDKARAENPDVKLFAMGDFNDDPVSSSLRKHLGAVGEPSQLSEKAPYYNLMTKLYKAGVASLAYRDAPNLFDQIIVSKNLYSPEKLTKTYSVYKVEIYAPSYLVNTAGQWKGYPLRSWDGDRFTGGFSDHFPAVSVVQREFSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X319</accession>
    <name>C6X319_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02399"/>
    <dbReference type="EnsemblBacteria" id="ACU08832">
        <property type="protein sequence ID" value="ACU08832"/>
        <property type="gene ID" value="FIC_02399"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02399"/>
    <dbReference type="HOGENOM" id="CLU_1238687_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="223" mass="26055" checksum="CFFCC41305A53C5B" modified="2009-09-22" version="1">MPKISFGIFMMKFNIIKRNKNIFGLITNAQYIALLLFCLMFGSLQFAAGNLVEIVLLLFCVSLFALIIYSMFDYEKLNAKRSGVFSLEKDYVQVGLVKILYPEIQSMMIETNFFKGQSRYPGVNSFWGPWNYIGKNNFVRIKCIDNRTFDFEFQLLSEIDLKQLNEQFAALLLDGKINFYSHSLHKVPSSIKQTPSFFLYVIKLVDEKIIGKEYSERILRDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X330</accession>
    <name>C6X330_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807127.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02410"/>
    <dbReference type="EnsemblBacteria" id="ACU08843">
        <property type="protein sequence ID" value="ACU08843"/>
        <property type="gene ID" value="FIC_02410"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02410"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096069_0_0_10"/>
    <dbReference type="OMA" id="AGMAYLN"/>
    <dbReference type="OrthoDB" id="1636416at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="236" mass="26429" checksum="BAFDF74A55D1740C" modified="2009-09-22" version="1">MAKITTRPDKHELEGKETVEVFKDLDRGALDTERFIEKHAKTLITVFVALVVAVLGYFAYEQFYVGPRNEEATLSYLAAQKNLADGKEELALGGKTAANPGYLGTYNEFSDTKVGKLSAYNAGLLKFKEGKYQEAFDLLDKFSSKNDILMALKYGAMADAQLNLNKNEDALSLLDKAMSSSDDPYTSYYFTRKAGLVALALKKKADAKKYFSAIDEKYQDYDNGMSDAYIEMVKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X367</accession>
    <name>C6X367_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807164.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02447"/>
    <dbReference type="EnsemblBacteria" id="ACU08880">
        <property type="protein sequence ID" value="ACU08880"/>
        <property type="gene ID" value="FIC_02447"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02447"/>
    <dbReference type="HOGENOM" id="CLU_2584592_0_0_10"/>
    <dbReference type="OrthoDB" id="2090158at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="84" mass="9370" checksum="5F463C7BD2E56807" modified="2009-09-22" version="1">MKTQLLTNKLEKFGIFILTFFFSVITLAQTGTTNPDLDVDVTTTETSTTTEEWFSNPVYWVIGALLLIVLIAVVARGNSNKRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X370</accession>
    <name>C6X370_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tryptophanase</fullName>
            <ecNumber evidence="6">4.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-eliminating lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.1" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02450"/>
    <dbReference type="EnsemblBacteria" id="ACU08883">
        <property type="protein sequence ID" value="ACU08883"/>
        <property type="gene ID" value="FIC_02450"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02450"/>
    <dbReference type="eggNOG" id="COG3033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047223_0_0_10"/>
    <dbReference type="OMA" id="EMYQYGD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009034">
        <property type="term" value="F:tryptophanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011166">
        <property type="entry name" value="Beta-eliminating_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001386">
        <property type="entry name" value="Trpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="69"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611166-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="480" mass="54362" checksum="DC4EE0E1D505529E" modified="2009-09-22" version="1">MSNHAIHFRKHYSLPITNYLSFMKLPYAEPYRIKMVEEIHQSTAEEREQWLKDANYNLFNLKSSQVYIDLLTDSGTGAMSDQQWGALMTGDESYAGSRSFDQLHDSVQNITGYPYLLPTHQGRAAENVLFSVLVKEGDVVPGNSHFDTTKGHIEIRKAHAIDCTIDEAFDIENLHPFKGNIDLEKLEAVYKNHPKEQIPFCLITITCNSSGGQPVSLENVKAVKELSDRYGIPIYFDSARFAENAYFIKKREAGQENRTIKEIAKELFSYGVGMTMSSKKDGLVNIGGFIALSDEKIFNAASNFTIIFEGFITYGGMAGRDMAALAVGLNEATEFDYLESRISQVEYLGNKLIDFGIPIQKPIGGHAVFVDSLKFLPNIPREEYPAQTLANEIYKEAGIRTVEIGTLLADRDPGTRENRYPKLELVRLAIPRRTYTNNHMDYIAVAIKNVYDRREEIEKGYNITWESDILRHFTVKLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X382</accession>
    <name>C6X382_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsA</name>
        <name evidence="8" type="ordered locus">FIC_02462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807179.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02462"/>
    <dbReference type="EnsemblBacteria" id="ACU08895">
        <property type="protein sequence ID" value="ACU08895"/>
        <property type="gene ID" value="FIC_02462"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02462"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_3_2_10"/>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="455" mass="49564" checksum="2F52A2D6CB8195EE" modified="2009-09-22" version="1">MENHEYSVGLDIGTTKIVAIVGRRNTHGKIEILGVGTAKSLGVHKGIVNNISQTIQSIKAAVTQAQASSGVEIHKVTVGIAGKHIRSLQHSDYIMRDNPDQYITENDIEKLKDQVKKLVMLPGEEIIHVLPQEYKIDSEGEIQEPIGMHGKRLEANFHVVVGQMGSIRNIARCVREAGLDMEALTLEPLASSESVLTKEEKEAGVAIVDIGGGTTDIAIFKDNIIRHTCVIPYGGGIITDDIKEGCSIIEKHAEQLKVKFGSAVPELEKDSTFVTIPGLHGRPDKEISLKTLAQVVSARVEEILEMVNTELKAYGAFEQKKKLIAGIVLTGGGSNLKNLRQLANYTTGFDSRIGFSNEYVANDKNQFLKGPEYATSIGLLMESLKIRDKKPTSPAAAKAVENAQPEIQAAAKVAEEAAPRTEDELIAEAAEKRRGKLTIGQKIMESVKKFFEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X396</accession>
    <name>C6X396_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-D-galactosidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02476"/>
    <dbReference type="EnsemblBacteria" id="ACU08909">
        <property type="protein sequence ID" value="ACU08909"/>
        <property type="gene ID" value="FIC_02476"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02476"/>
    <dbReference type="eggNOG" id="COG1647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_10"/>
    <dbReference type="OMA" id="VYILENC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="263" mass="29738" checksum="1433A2E59BFE0FFA" modified="2009-09-22" version="1">MQRLGSNFMRFITKKEKKFSFIEAGEGHPLILLHGLMGGLSNFDKTVKFFSEKGYKVFVPVLPVYDLPVLHTNLTTIAKYVAKFIAEKCTEPVTVVGNSMGGHIGLILTLARPELVKNLVLTGSSGLYERTFGDSFPRKSDKDYIRKKTEEVFYDPIVATDELVDEVFSVVNDRMKGIKTVMLARSAIKHNMLNDLPKIATPVCLIWGRQDNVTPPEVAEDMNKSLPNSSLYWIEECGHAAMMEKPDEFNNILYSWLQKVQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E6</accession>
    <name>C6X3E6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02529"/>
    <dbReference type="EnsemblBacteria" id="ACU08959">
        <property type="protein sequence ID" value="ACU08959"/>
        <property type="gene ID" value="FIC_02529"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02529"/>
    <dbReference type="HOGENOM" id="CLU_3043630_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="54" mass="6203" checksum="7D78D7E53E4009F0" modified="2009-09-22" version="1">MYEKPFPRGNSRTVNRAAIQIAGVDEAIDDKRVLMLESCFAKRNTQIHFPKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N2</accession>
    <name>C6X3N2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00562"/>
    <dbReference type="EnsemblBacteria" id="ACU07020">
        <property type="protein sequence ID" value="ACU07020"/>
        <property type="gene ID" value="FIC_00562"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00562"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914479_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="304" mass="33420" checksum="4583A68B7A2C4CF9" modified="2009-09-22" version="1">MQQPESADGQVYYEYSDFRTTLKHIQMKNKYLLLLLFSCAGISAQVGINTRSPHPSAALDIRANNKGVSFPQVSLAGKMDVSTVSNPKESLIVYNTNTALTGSEGYYYWNGTRWDYFFSDLNQSNLLNQVKYYSATSTTGYDFTSSSPNQFLGYSAHSLGETLNTTQWTVITGITKSIYVDRANSQTLMSINGMYQANNSSASSDGITSTIGFFIDDKLIDVKPMFLEFASPCAYRQFMIYGIASNLPTGTHTVKFAIRNIEAPNTAGLTVSYGKANPSATCNTVSAFEAAISSTIFINQPYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q1</accession>
    <name>C6X3Q1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782186.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00584"/>
    <dbReference type="EnsemblBacteria" id="ACU07039">
        <property type="protein sequence ID" value="ACU07039"/>
        <property type="gene ID" value="FIC_00584"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00584"/>
    <dbReference type="eggNOG" id="ENOG5032CJG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1842161_0_0_10"/>
    <dbReference type="OMA" id="TCEYCFS"/>
    <dbReference type="OrthoDB" id="1776681at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="137" mass="16504" checksum="8E81B3B2C60FF1E1" modified="2009-09-22" version="1">MPLSEQLFSLLVLAIPIACVAWTVTHEEIFREPREYCVKKSQESEKLYQRKFFYLFTCEYCFSHYVTAIFLIITNYQLLFDDWRGYLISFFALVFVANVYMSLFAFLRQSLKVEKIEAKLKDNEWHEVKEEIEVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q8</accession>
    <name>C6X3Q8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00591"/>
    <dbReference type="EnsemblBacteria" id="ACU07046">
        <property type="protein sequence ID" value="ACU07046"/>
        <property type="gene ID" value="FIC_00591"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00591"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039603_0_0_10"/>
    <dbReference type="OMA" id="FEHDMSG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="390"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="490" mass="56344" checksum="B863E46DDDD9510C" modified="2009-09-22" version="1">MFSTICLNFSVFSWFCITQNYVFKSSGRPILLKKNKPDCKKLYLQIMKFMITICLLFSALCFSQQGFKISGKSKTVIPFRLINNLIFIPLNINGVNLTFLLDSGVNETILFSLDNKEVNFNDIEKVKFAGLGESKNIEGLRSDNNRVAVGEDFVDSAHTVFIILDESINFSAHVGIPVNGIIGYQFFKNYPVKIDYISKKITVLSDPNGFIRQRKRFTELPITIEANKPYLIAGVEQKDKKTDSKMLLDLGNSDPVWLFPKLIKDFVYNRPNIYDYLGQGFNGDIFGKRSRIHRLYIGDFVFEKPLTAMPDEYSIQNLKLVPERKGSVGSEILRRFTVIFDYPNNRIFLRKNRHYKDLFLINKSGLDIQHDGMTWENDIVKVETRKTSPNSEGINVYDVSEGFRYNFVLKPKYSVAGCRKDSPCDLAGIQKNDRLIRINRKKVGDLTLQRINEMMKAEDGTRVNLEIERNGALKNIEIILMDPIPYQDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R9</accession>
    <name>C6X3R9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782204.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00602"/>
    <dbReference type="EnsemblBacteria" id="ACU07057">
        <property type="protein sequence ID" value="ACU07057"/>
        <property type="gene ID" value="FIC_00602"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00602"/>
    <dbReference type="eggNOG" id="ENOG50339GS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1364524_0_0_10"/>
    <dbReference type="OrthoDB" id="2221725at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970632" evidence="2">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="200" mass="21674" checksum="141DE8B79DEFEC0E" modified="2009-09-22" version="1">MKNIIKNIAALLAVGSLSSCIAYQDGQAANSGYYDPYYNSGVYYAPSSYYGGGGYYGNDGYYYRNDMNYYYDNGIPYYVGRNNTRIYIVKQSNAANGGNSNTARFRNNGSAVNSSANSSVRTQNSSVRGFRTPAANTPARQQNQSLRNTNTNRTPAAAAPRTSNERSFRNTTPQAAPSAPAPGGLRAEPQTNRDGTRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W7</accession>
    <name>C6X3W7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07105">
        <property type="protein sequence ID" value="ACU07105"/>
        <property type="gene ID" value="FIC_00650"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00650"/>
    <dbReference type="HOGENOM" id="CLU_3381967_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="33" mass="4182" checksum="918829CCAD729D3B" modified="2009-09-22" version="1">MISNLLLSKKDHLFLKYQWEFRKLDFLFFYLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X4</accession>
    <name>C6X3X4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782258.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00657"/>
    <dbReference type="EnsemblBacteria" id="ACU07112">
        <property type="protein sequence ID" value="ACU07112"/>
        <property type="gene ID" value="FIC_00657"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00657"/>
    <dbReference type="eggNOG" id="ENOG5032S8D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192047_0_0_10"/>
    <dbReference type="OMA" id="MYGALEV"/>
    <dbReference type="OrthoDB" id="1948228at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="82" mass="9206" checksum="9C62FB7C1B294EB8" modified="2009-09-22" version="1">MKLPIIRQFYQTQTAENLEKTLEVLEAFSEFRGTTEEDLNVAGELITNICGALEVHQNVKNGQPERDALNAFAQKVLGSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z3</accession>
    <name>C6X3Z3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782277.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00676"/>
    <dbReference type="EnsemblBacteria" id="ACU07131">
        <property type="protein sequence ID" value="ACU07131"/>
        <property type="gene ID" value="FIC_00676"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00676"/>
    <dbReference type="eggNOG" id="ENOG502Z9DG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100162_0_0_10"/>
    <dbReference type="OMA" id="VCKFITV"/>
    <dbReference type="OrthoDB" id="1193095at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="242" mass="27520" checksum="F8CC25B48EFE2FD4" modified="2009-09-22" version="1">MNANKLKIILWSVGILLMLFLAFFLYQMTQSESVNSMMTLLMLLLGLILGGVIAFLASKKLKSEAPVITESSHTIAESMRKVFKVVSAEGHFNEIYNYEETTKLFNFIPSKKKALVIVQAKVLVGYDFEKFQWEVDEQNRKVKLLNFPPPEILSTETDYKYYNIEEQFFNLFSKDDLAKVQQNGKRQVIEAAKKSHLPGVAAEQMRTLLTELLAGKNFILENPAKISESKNTIDYKAMNSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z7</accession>
    <name>C6X3Z7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00680"/>
    <dbReference type="EnsemblBacteria" id="ACU07135">
        <property type="protein sequence ID" value="ACU07135"/>
        <property type="gene ID" value="FIC_00680"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00680"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091665_0_0_10"/>
    <dbReference type="OMA" id="ISHHHEN"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="213"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="280" mass="32507" checksum="8C9D62FF5E9FF34D" modified="2009-09-22" version="1">MWYIRITFIILVQINYRMKKIIANPPNQHILTEVWQNDPEIFNFDIKPVAPPALEKIFADFFSVGKYYYYVLSIAESTISHHHENILEMHGLKEYPQTLAEIINLIHPDDIPFVIEAEKMSYEKVKSIGRQHFPQLKTSYCFRMKTATGSYELFHHQALHTLQSESGQILQAVNIHTNIHHLTQKNPYTVLVSGLEPRRDFHQMHYNKSPNVIGGDFVKLTQRETEILSLIARGYSGSEIAKNICVSEHTVKSHRRNIIAKMRVRNTKELISKAIEMAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X451</accession>
    <name>C6X451_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782335.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00734"/>
    <dbReference type="EnsemblBacteria" id="ACU07189">
        <property type="protein sequence ID" value="ACU07189"/>
        <property type="gene ID" value="FIC_00734"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00734"/>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086031_0_1_10"/>
    <dbReference type="OMA" id="LFNGKYD"/>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="212" mass="24183" checksum="B8878D5BC6DE83E3" modified="2009-09-22" version="1">MGIGNIFKAFQPKDKVFFVLFEKVAETLTEMSKEFHEGLLDFDINDDTMLTNMSDYEHKLDDLTHEIFVQLGENFITPFDREDISHLASALDDIADFMYASAKYIYLYKTPLDPAYSEFSLLIYKSCLEIQSAMGNLKEFKNAKAVKESCIKINSFENIADDVLSQATVKLFETNDAINIIKIKSVLEYLETVTDKAEDVANIMDSIVIKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X482</accession>
    <name>C6X482_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00767"/>
    <dbReference type="EnsemblBacteria" id="ACU07220">
        <property type="protein sequence ID" value="ACU07220"/>
        <property type="gene ID" value="FIC_00767"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00767"/>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_6_0_10"/>
    <dbReference type="OMA" id="WELIYVE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="86" mass="10302" checksum="901BA76B52B051CB" modified="2009-09-22" version="1">MLGDFFVMYYVYILYSARLDVYYKGFSADVEKRLEYHLHGKHKFTSTARNWKIVYTAAFEGKREAVKEEKRLKRLNRQSLQKLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B5</accession>
    <name>C6X4B5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782399.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00800"/>
    <dbReference type="MEROPS" id="S13.002"/>
    <dbReference type="EnsemblBacteria" id="ACU07253">
        <property type="protein sequence ID" value="ACU07253"/>
        <property type="gene ID" value="FIC_00800"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00800"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017692_1_2_10"/>
    <dbReference type="OMA" id="DGTMRKR"/>
    <dbReference type="OrthoDB" id="720131at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970652" evidence="2">
        <location>
            <begin position="22"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="486" mass="52988" checksum="86677E701D25E5E1" modified="2009-09-22" version="1">MIRLKNIFLAQALAFSAITFGQGTYASSNYPQSFENRPSSVVKEVSAPEKLMTAKELLDININAMAGDPVLRNANWGFVVFDPKTKKIVSSYNENTPLIAASTTKLLTTDTAMSLLGSNFRWHTQLEHSGTVDADGVLQGNLYIVGSGDPSLGTNKAGASSYSAVVSDFLYALSEKGIKKVNGDIIIQTGIFKANKMQRLPENIVWLENGSYYLPAGSTFQISPQNEKLIAKSSNPFNENKNFYYISPYIKQMVYADKFEGAGLTTKVADPPAYLANTMRASMIKKGVHVSGKVITKITDVDPEIRTKVAVYASPTLGEIVHYINQRSDNALAEATLRTVGFQKEGDQTLESGRRVVTDHLKSINFDTSGLNYMDGSGLSRGNVVTPISQAKFLTGLMDEKYFKTYFESLPVAGQSGTLKNTFTGEGNGQIFAKTGTLNKVKTLAGYLKTNTGKTLVFSLLINNYGGSVDQVKVRMEQILKPALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D1</accession>
    <name>C6X4D1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate starvation-inducible protein PhoH, predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782415.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00816"/>
    <dbReference type="EnsemblBacteria" id="ACU07269">
        <property type="protein sequence ID" value="ACU07269"/>
        <property type="gene ID" value="FIC_00816"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00816"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_10"/>
    <dbReference type="OMA" id="PAQMKMV"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="107"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="319" mass="36252" checksum="8B5671DD4CA461AE" modified="2009-09-22" version="1">MFELNYEITGIDAKTFYGVNNQYFNVLKSTFPTLKITGRDHFVFAQGNNETLDVLKLKLDDIVSFISKYNSITLKDVENILNIKDETEKQLVFDQDIIVKGVNGKIIKAKTTNLKILVKECEKKDMVFAIGPAGTGKTYTSVALAVRALRDKEVKRIILTRPAVEAGESLGFLPGDLKEKLDPYLQPLYDALRDMIPHEKLEGFIEKKVIEVAPLAFMRGRTLDEAFVILDEAQNTTHSQMKMFLTRMGMNAKFIITGDPSQVDLPLRQKSGLKEGMRILKDVKEIGFVHLTEEDVVRHPVVRKIINAYGKEEQRQRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E1</accession>
    <name>C6X4E1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ordered locus">FIC_00826</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782425.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00826"/>
    <dbReference type="EnsemblBacteria" id="ACU07279">
        <property type="protein sequence ID" value="ACU07279"/>
        <property type="gene ID" value="FIC_00826"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00826"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_5_0_10"/>
    <dbReference type="OMA" id="QTAMIII"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU07279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="64" mass="6274" checksum="1F8E528D252163B4" modified="2009-09-22" version="1">MEIPKLVGAGLVVIGAGLGIGKIGAAALEGMARQPEQAGKLQTAMLIAAALVEGLAFAALFAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H3</accession>
    <name>C6X4H3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00858"/>
    <dbReference type="EnsemblBacteria" id="ACU07311">
        <property type="protein sequence ID" value="ACU07311"/>
        <property type="gene ID" value="FIC_00858"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00858"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121365_0_1_10"/>
    <dbReference type="OMA" id="TWCGDSK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668776" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="21251" checksum="1719E7DC37C5D965" modified="2009-09-22" version="1">MNMKKLTQIILLAASLSITMQSCQAQKVVVNREVETESDGKMLLGTQTKSQLSMAPYSDWYNSEHKEYTVDQTAVAELKKEKLSSYNIVLVLGTWCEDSHRQVPRLMKILEAVDHPESKLTIIGVNRKKEAPGGEEGTYNIQNVPTIIVQKYGKELGRIVENPSTGYIERDLLEILKKDNSNIKELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L2</accession>
    <name>C6X4L2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA binding protein with S1 RNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782496.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00898"/>
    <dbReference type="EnsemblBacteria" id="ACU07350">
        <property type="protein sequence ID" value="ACU07350"/>
        <property type="gene ID" value="FIC_00898"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00898"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_10"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="637"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="707" mass="78886" checksum="1625741AB024C9D1" modified="2009-09-22" version="1">MTATGFIQQSLQISDKSIHATLKLLGEDCTIPFISRYRKDATGNLDEVQIEQIAKLNTQFEELSKRKESILKSITEQDALTPELKQRIDSSFDLQELEDLYLPFKKRRKTKADTAKEKGLEPLAKIIMSQKANDLESLAAKYLNDDVAAEEEALQGARDIMAEWINENGYVRKNLRRLFQRKAMISSKVVKAKKEDEAAQKYSQYFEWEESLNRIPSHRLLAMLRAETEGFVKTKIEIDKDEAIDLIEQAVIKSRNECAEQISLAIKDSYKRLLEPAISNETLQEAKEKADAKAITIFSDNLRQLLLAPPLGEKRILAIDPGYRSGCKIVCLDEKGDLLHNETLYPHAPQNETGMAMKKIRSMVNAYNIQAISIGNGTASRETEFFIKKIAFDKPPQVFVVSEAGASVYSASKIARDEFPSFDVTVRGAISIGRRLSDPLAELVKIDAKSIGVGQYQHDVDQTQLKNELDSTVMSCVNSVGINLNTASKSLLSYVSGIGEKMAENIVNFRTENGAFEDRKQLKKVPRLGEKAFQQAAAFVRIANGKNPLDNSAVHPEAYPTVEKMAKDLGLKTVDLIANKEKIAAINAEKYVTETIGILGIKDILKELEKPGLDPRKAAKVFEFDPGVKSIKDLKTGMILPGIVNNITAFGCFVDLGIKESGLVHISQLKEGFVSDVNEVVKLHQHVQVRVTEVDEARKRVQLSMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P0</accession>
    <name>C6X4P0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00927"/>
    <dbReference type="EnsemblBacteria" id="ACU07378">
        <property type="protein sequence ID" value="ACU07378"/>
        <property type="gene ID" value="FIC_00927"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00927"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031960_0_1_10"/>
    <dbReference type="OMA" id="EWMKGNA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="295" mass="32921" checksum="72E3BDD66B891064" modified="2009-09-22" version="1">MDMKKITLFFLFISALNFSQNSVLKKQIQQIIKDKNATVAVSVHDFENNKTIHINGNKKLPMLSVFKFHIALAVLNEVDEGKLSLDQNIFIKKSDLAENTWSPIRDRFPDGNIEIPLSLLLKYTVAESDNNGCDIVLRLIGGTGTVQKFIDSKDVKDFTIKADEAQMHRGDEFLYWNVTSTNSANKLLKDFFDKKTVSKPSTDFLMNTMLETTTGQNKLVAQLPRGLPVAHKTGSSGKNSEDLTIAENDIGIVTLPNGKHYAISVFVSDSMESEATNTKMIADISKIVFDYFSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S2</accession>
    <name>C6X4S2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782556.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00959"/>
    <dbReference type="EnsemblBacteria" id="ACU07410">
        <property type="protein sequence ID" value="ACU07410"/>
        <property type="gene ID" value="FIC_00959"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00959"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_10"/>
    <dbReference type="OMA" id="ITGGRNW"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="234" mass="25285" checksum="113BB5EC6B15468A" modified="2009-09-22" version="1">MDGKVAYITGGTKGIGFGIAEVLLKNSIKVAVSGRKQEDAEEAAKILSSDASQVLGIASDVKNAADEERAVAEIIKKFGRLDYVIANAGLGVFKPVDQLSLDEWNGMIETNLTGIFHTLKATVDELKKNEGYYITISSLAGTNFFENASGYNASKFGAVGFTQAAMLDLRKYNIKVSTIMPGSVSSNFNGNEPSEKDAWKIQPEDVGELILNIFKMNPRTLPSKIEIRPSKPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S5</accession>
    <name>C6X4S5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensory box histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782559.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00962"/>
    <dbReference type="EnsemblBacteria" id="ACU07413">
        <property type="protein sequence ID" value="ACU07413"/>
        <property type="gene ID" value="FIC_00962"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00962"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599565_0_0_10"/>
    <dbReference type="OMA" id="NINQRME"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="361"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="456" mass="51731" checksum="79DA7ECA887C7C76" modified="2009-09-22" version="1">MELFVWNMAISYQLLFVILSGTVFYYLREPCFKHYALYNFFLAVYVITRNDAYYALLESSAARFLGAGNAHIFIYIVFFYVQILFYTFYSHFALYFLDLDAHVKKYFNRVILALKILGVSMIATGIISYITKDIGLPMTVFTYVYLPSLLIIFLATLLYAVRFSGQHRKFFLIGICCFVTLGLVAFIGSRVDALDVENPINFFYIGIILETLFFNLALAHKLKLLNDEKNRVRREMTRSKHRLQLSKLHGLLEGEERERKRLAEELHDGIAGDLAAIKFNLHALKTNHRSSGDEELIGELTQIIDRSCVQIREISHNLSPSTVTNFGLMTALENFCLQNQTIHGISIGVNFSGEPATLSKSVETHLYRIIQELITNTVKHAGAKHAAIHIWHHAPYFTVTVTDDGKGFSQNGNTPGIGLSNINSRIRFLNAGIKKETTAIGSKFVIEIDLRKLPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V1</accession>
    <name>C6X4V1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782585.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00988"/>
    <dbReference type="EnsemblBacteria" id="ACU07439">
        <property type="protein sequence ID" value="ACU07439"/>
        <property type="gene ID" value="FIC_00988"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00988"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072818_0_0_10"/>
    <dbReference type="OMA" id="SWGKHFL"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="10">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="245" mass="28361" checksum="81F4B7D81C08216E" modified="2009-09-22" version="1">MPEGPSILILKEATQKFIGEKVISATGNAKIAMEKLPDLTFEEYRIFGKQSYLVFGEAVIRVHLLLFGSYSVDEQIKPDRQLRLQLKFPNGDLYFNSCSVKLLERSVLREIDWHADVLSDDWKPLKARKKLKLQPERMACDVLLDQNIFSGVGNIIKNEVLFRIGVHPESLVGNLPPKKLSALIFEARNYSFDFLRWKKEYVLKKNWLVHTKKTCPKCGELLTKRHTGLSNRRSFFCEKDQKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V3</accession>
    <name>C6X4V3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyguanosinetriphosphate triphosphohydrolase</fullName>
            <ecNumber evidence="2">3.1.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.5.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782587.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00990"/>
    <dbReference type="EnsemblBacteria" id="ACU07441">
        <property type="protein sequence ID" value="ACU07441"/>
        <property type="gene ID" value="FIC_00990"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00990"/>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028163_2_0_10"/>
    <dbReference type="OMA" id="ICYTIID"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023293">
        <property type="entry name" value="dGTP_triP_hydro_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027432">
        <property type="entry name" value="dGTP_triphosphohydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="55"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="451" mass="51482" checksum="8B80E3287B84BA95" modified="2009-09-22" version="1">MDLNRIFTNQRTGQNVATSASRTDYQRDFDRIIFSAAFRRLQNKTQVFPLPGSVFVHNRLTHSLEVSSVGRSLGSAAGDFIFENYRNDLDENAQNFYQHNLHNVIAAACLCHDVGNPAFGHSGEDAIASYFEKNEADLKPKFNEKEWADLMNFEGNANAIRVLTHQQNGKDEGGTQLTFSTLGSIAKYPCEAVAKNRAVIHQKKFGFFQNEKDTFLQIANSVGMMQESDEPTAFKRHPFVWLVEAADDICYNIIDMEDAHRLGIVSTADCENLFFELIKSENQNTKRVEDKLAMLTNANERISYLRAKVINALINKSMQIYRENFDLILNGNLDKALLDIYKTDNRSLQEIESFSIEKIYNHKAVIEIENAGYNVMYELLDHFIPPILKSKEDRKSYDKMALKLLPKQFLYEEGTDYQKVLGVIDFVSGMTDNFATDLYRKIKGIEIGMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X5</accession>
    <name>C6X4X5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782609.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01013"/>
    <dbReference type="EnsemblBacteria" id="ACU07463">
        <property type="protein sequence ID" value="ACU07463"/>
        <property type="gene ID" value="FIC_01013"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01013"/>
    <dbReference type="eggNOG" id="ENOG502ZQC9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050831_0_0_10"/>
    <dbReference type="OMA" id="LVGQTWH"/>
    <dbReference type="OrthoDB" id="837523at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973468" evidence="1">
        <location>
            <begin position="23"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="439" mass="48230" checksum="89F85FFA59AF4119" modified="2009-09-22" version="1">MKKLTVLLGILPVLFFSAQVNAQDTISNTDLLKRIEALEAEKTKPKEWDASLYGWVRTDYSFDSRQSGYSREYNLNLYPLDEKLDANGKDINNTGASNFLAITSRIGIRFRGPDVWGAKATGNIEGDFFGNTELNKTSAGTGSAGLFRLRHATATLTWPKTALTFGQTWYPAFIPDVFPGVANFNTAILFNPFGWAGQVKLTQKITPELSFTVVAYKDREFQTANATGASANSATFNSSVPTFHGQLLYRGKNMVAGAGAEYQSLKPVIESAGLASDETVNSEMFFGYFKYANEKIIAKLYGIAGGNLHHLVMIGGFAGYENPDGIESYKPTKTSAFWVDLASAHPKIAPGVFFGYTKNSGVDAGFKNLYVRGLSGTRILNNVWRASARVDFKQNKFNISPELEYTAAQWGDLNAEAIAQNNLKDVGNLRALIRVMYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z6</accession>
    <name>C6X4Z6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01034"/>
    <dbReference type="EnsemblBacteria" id="ACU07484">
        <property type="protein sequence ID" value="ACU07484"/>
        <property type="gene ID" value="FIC_01034"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01034"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534892_0_0_10"/>
    <dbReference type="OMA" id="ISHIMIT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970679" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="415"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="482" mass="50727" checksum="47B956839CC247DE" modified="2009-09-22" version="1">MMMTKISFIIVFLLFLFSGNTQAQTDGNPDTSFVVGTGFNNAVMSTAVQPDGKILAAGWFTSYQGTVQNRIIRLNTDGSPDPSFNTGTGFSGTGDVYVNTLALQPDGKILAGGTFTAYNGITQNRITRLNADGSLDTTFNTGTGFNTPAGGFIFINTIAVQSDGKILAGGRFSAYNGTAQSHIARLNPDGSQDSFSPGSRFSSDINTIAIQPDGNILVGGSFTYSGNTITQKNLVRLDTAGNHDPSFDIETGFAVGAGAVRIDAIALQPDGKILVGGYFNTYKGVSQNHLTRLNTTGNRDTSFATGTGFNFPVNTIAMQADGKILLGGGFSTYNGSTANRMARLKTDGGLDAAFNTGAGFSGTLGNVESISIQSDGKYLTGGYFTTYQGLPRNRIARLNGTTLAVGDSGKNEMVLYPNPVGGTLYFSEEISHIMITDLSGKAVNQMSVNRTSADVSELPKGIYFVTLTTISGDAITRKIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X542</accession>
    <name>C6X542_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01080"/>
    <dbReference type="EnsemblBacteria" id="ACU07530">
        <property type="protein sequence ID" value="ACU07530"/>
        <property type="gene ID" value="FIC_01080"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01080"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_10"/>
    <dbReference type="OMA" id="RSHVICP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="286" mass="31741" checksum="6252C7697311621F" modified="2009-09-22" version="1">MYPNKKYKMMNNQKVWLITGASKGLGLALTKLALSQGQKVVATSRNIEDLKTSVPENPELFLPLKVDITSDKEVKNAIEQCIEKFGRIDVVVNNAGYSLVGSMEEMTDEEFRKTVGVNLFGTVNIIRNAMPYLRQQQSGHIINIASNAGYVGFANATSYNAAKFAVIGLSEGLAAEVSPFGIKVTVVAPGQFRTSFMDKGSMTFAENKIEVYGLAKAEKMWTDFSGQQTGDPEKLVKILTEIVELETPPLRLLLGPDTFELVKQQREQEMLEFEAWKHLTLSTNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X575</accession>
    <name>C6X575_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01113"/>
    <dbReference type="EnsemblBacteria" id="ACU07563">
        <property type="protein sequence ID" value="ACU07563"/>
        <property type="gene ID" value="FIC_01113"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01113"/>
    <dbReference type="HOGENOM" id="CLU_3356317_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="36" mass="4117" checksum="CB7C183486B54168" modified="2009-09-22" version="1">MIKITFKNETSPFFFTFIFSISYPGFRIQPGKPGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X579</accession>
    <name>C6X579_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible 2-component sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01117"/>
    <dbReference type="EnsemblBacteria" id="ACU07567">
        <property type="protein sequence ID" value="ACU07567"/>
        <property type="gene ID" value="FIC_01117"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01117"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_1_3_10"/>
    <dbReference type="OMA" id="SIQSHAY"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="286" mass="32823" checksum="13B98217E0D90E4F" modified="2009-09-22" version="1">MRCGRHMLRGINNGQPAITAPHFAGKSFIFAAETATSMEFFHVPILICFLLLAALAAVIWELVKSRRQRSALTKEVCTLKKKLGAVKLDYIETKLNPHLFKNILNSVQSHAYQTYTALDKLSGVLDYVLYESSERFVTPQQEFEFTKNLIDINRIKVNPLFDFRVKFHIDENDAVFHEKVLAPMVTADFIENAFKHTDFLADDSFILVRLSLEKGVLELKVQNKVSAKAPMEKDHSGFGTASLEQRLKIVYRKNFAVRKDEQGGIFTAHLKIDLNERYNQVHYTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X580</accession>
    <name>C6X580_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805853.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01118"/>
    <dbReference type="EnsemblBacteria" id="ACU07568">
        <property type="protein sequence ID" value="ACU07568"/>
        <property type="gene ID" value="FIC_01118"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01118"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_10"/>
    <dbReference type="OMA" id="CRINKKE"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="237" mass="26596" checksum="3BD4838713BCD74B" modified="2009-09-22" version="1">MNGTIRCIILDDELLAVSYLQLLCQEIGGVEVVKAYNNPEAFLRDIRPDSCDVCIMDIEMPGMNGLEIAAKIPYMQIIFTTAYKEYAAEAYDLNVADYVRKPLQKERLRQALAKIKPAAGPEGKTAFEWNTGLGKTRIFTGSLLYFRTSAIDARDKTAFLEDQSVLTLKNINFRDLLGMLPESEFVQINKKEVIALKTVQAFTDTEIITARRGPDALPVKFQLTKAFRAGFIEKIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X583</accession>
    <name>C6X583_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Osmosensitive K+ channel histidine kinase kdpD</fullName>
            <ecNumber evidence="4">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01121"/>
    <dbReference type="EnsemblBacteria" id="ACU07571">
        <property type="protein sequence ID" value="ACU07571"/>
        <property type="gene ID" value="FIC_01121"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01121"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_113_4_10"/>
    <dbReference type="OMA" id="LNVEREN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KdpD" evidence="3">
        <location>
            <begin position="61"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="416" mass="47134" checksum="25B7A8109CB78467" modified="2009-09-22" version="1">MFTMTEVSALAAYLPQPLWPSVFRITGKTRLLLHKKPTSPKKMDEERKTAEHFLQLIKKSRRGKFKLYIGMSAGVGKTFRMLQEAHTLLRSGIDVKIGYIETHRREETAALLEGLPLIPRRTLFYKGKELEEFDVQAVINLRPEVVIIDELAHTNIEGSKNQKRWQDVFEILDAGINVISAVNIQHIESLNDEIRNITGISVQERIPDSVVAQADEVVNIDLTADELIARLKEGKIYNAEKIEAALTNFFQSDHILQLRELALKEVATQVNRKVETEVLKPNTLKHERFLACISSNEKSAKTIIKKTARLANYYHSKWFVLYVQTPAENADKIALSKQRHLINNYKLATELGAEIISISHSSIPKAIISQVEEKKITTVCIGKPRLTLWNLIMATGTFPLLLKKLAAEKVDTVILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5A3</accession>
    <name>C6X5A3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rifampin ADP-ribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805876.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01141"/>
    <dbReference type="EnsemblBacteria" id="ACU07591">
        <property type="protein sequence ID" value="ACU07591"/>
        <property type="gene ID" value="FIC_01141"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01141"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090934_0_0_10"/>
    <dbReference type="OMA" id="RVYIIEP"/>
    <dbReference type="OrthoDB" id="936538at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038611">
        <property type="entry name" value="Arr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021975">
        <property type="entry name" value="Rifampin_Arr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12120">
        <property type="entry name" value="Arr-ms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Arr-ms" evidence="1">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="247" mass="27342" checksum="9D73B98B4F65886D" modified="2009-09-22" version="1">MEFSPFNPIVKLCLQGMEMEENGKPEEARRLFTQSWDEATNDFEKFLAAHYVARHQHNVADRLKWLETGLHFALKVNSPAADSALPSLYLTISRCYEELGDAEKAKSYSGLANLSANNLTDNGPFYHGTKADLQTGDVLTAGGGSNYKAELKMNHIYFTALVDGAALAAALAKGDGNERVYIVEPTGNFENDPNLTDRKFPGNPSRSYRSEAPLKIVGEVKGWAAQTPQAIQKFREKLENNRGEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D1</accession>
    <name>C6X5D1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA ligase</fullName>
            <ecNumber evidence="3">6.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805904.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01169"/>
    <dbReference type="EnsemblBacteria" id="ACU07619">
        <property type="protein sequence ID" value="ACU07619"/>
        <property type="gene ID" value="FIC_01169"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01169"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_5_0_10"/>
    <dbReference type="OMA" id="FVVQIHD"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigD_N" evidence="2">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="204" mass="23227" checksum="F91C8411EE63F55D" modified="2009-09-22" version="1">MKNLEEYNKKRDFEQTAEPEGKIKSSKGKLKFVVQRHAASRLHYDFRLEMDGVLKSWAVPKGPSLNPADKRLGMMVEDHPFDYRTFEGSIPEGNYGAGEVEIWDEGTYEPLNKVSGRTDDQTMQQELKSGSVKIIMHGKKLKGEFALVKIKNAEDGNPWLLIKHKDEFAADHYDAEENTDPDSKVSEYLRAKKKVVAAAGKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D9</accession>
    <name>C6X5D9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805912.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01177"/>
    <dbReference type="EnsemblBacteria" id="ACU07627">
        <property type="protein sequence ID" value="ACU07627"/>
        <property type="gene ID" value="FIC_01177"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01177"/>
    <dbReference type="HOGENOM" id="CLU_1292804_0_0_10"/>
    <dbReference type="OrthoDB" id="1958734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973718" evidence="1">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24675" checksum="AC6A0CBED7EECA17" modified="2009-09-22" version="1">MKKTILIACLLCTVYAAAQTYAFDFVTKYALNAKDDKRQESVVYFNSDDFSYNLRLQKFPDRFRAILIDEDEKTAHRFDVAESRIKGEIVFSFTYTDSFKLNGTIKTYSRNEVSEIPGNPKQVLMKVYHSKRAKKPSHEHLLTLQPANKNLFAMYSISRSHAPFSLMNKSVDYPGNYIVVRDEITEGKVKCELVLEEHRNVELVLNLPKKLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G2</accession>
    <name>C6X5G2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805935.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01202"/>
    <dbReference type="EnsemblBacteria" id="ACU07650">
        <property type="protein sequence ID" value="ACU07650"/>
        <property type="gene ID" value="FIC_01202"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01202"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017617_1_0_10"/>
    <dbReference type="OMA" id="PWESHSI"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970700" evidence="1">
        <location>
            <begin position="19"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_3" evidence="2">
        <location>
            <begin position="365"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="772" mass="87669" checksum="F5583C4639490DBA" modified="2009-09-22" version="1">MSKLIKLLTLFLSLAIFAQQESFKIKGNISDSKQKQLSSAAIYLFTGNNELVKTTIAQDGHFEFSQLKPAPYHLQIVTNEITQNEPLFQLTSDITLHIKLNEKVSDIEEVQILRSSNPFKVQNGNIDIDVANSSLSKVATSTDLLAKLPFIYVDANGEALSMVGKGIPLLYIDNQKVDFKVLSAVSVDEIKSVEIIRNPSAKYEADGKAVIKVVLKSSKKEGYRMTLNETAVFNKRFSNNFSAHFQQKKNKTEWKINAAYNQIQHWESNGFDYSVPGRNIKSDYIITSTTTRPQVILGASLYRELKDGDHLTFTVNGNLRPDKGDNITVTNYAVNGLKSRILTLNHQDRERATVNSVFNYNKQLKSINATIFTGFQYTRESNNVDLDFYNNIDNSGYNFSQFRKQKYAVNAYAGRIDIEKKIKEDYQLGIGGSFTKADATTNNLTDYRNLNPSEYFKYFFDEENWASYAEFSGEREKLSFKGGIRVETASANGYSQILDETNINRHDVDWFPSAELSFRQNEHYVYTVNFRRSISRPGYSNVASGGLYSSPYVEYQGNPDLLPSYTNEISASVNLKQWTINASVYQIKNPTGFGLFYDETKNISQFTTENFDRESGASLGLDVPFQYKIVTSQNSLSFNYSKTEDSLAVVNPSTPYLYLYTNNTVKIGKGFNFLVDGTWITKRTQGIYEYNEMVLINLGLTKSVSNFDFTLRYNDIFNQNTYVQKLSYDKIITKGSFYGNTPVVSVGLKYNFGKVSNSEYKEKQINETVDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I2</accession>
    <name>C6X5I2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805955.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07670">
        <property type="protein sequence ID" value="ACU07670"/>
        <property type="gene ID" value="FIC_01222"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01222"/>
    <dbReference type="HOGENOM" id="CLU_1213348_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="193" mass="22590" checksum="2063694009B5ED95" modified="2009-09-22" version="1">MKRIYLIFLLIIAQTVFSQKDNRIENIGEATSQLLIKGDDIDNFKYAIKIQSLYPNEDFSKFKDSPAEVILNMLHGAELELPKAWNEVVKESGEYKIDKTSKYVFTYSHKMGVDNYIATSVIESQSKYYAFSYNLLQWGEDIYISRFYKKVMEFETVEQIDSNPFVIIHDEMQKELNEIDENHSEEILIGPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J7</accession>
    <name>C6X5J7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805970.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01237"/>
    <dbReference type="EnsemblBacteria" id="ACU07685">
        <property type="protein sequence ID" value="ACU07685"/>
        <property type="gene ID" value="FIC_01237"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01237"/>
    <dbReference type="eggNOG" id="ENOG502Z9VN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042391_0_0_10"/>
    <dbReference type="OMA" id="MHRNNAF"/>
    <dbReference type="OrthoDB" id="1334916at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="525" mass="59355" checksum="618C98DF45971A02" modified="2009-09-22" version="1">MKTLTKALPLAVSFFFILLFIYASASKILDFENFQMQLAQSPLLSAYAGFVSYAVIIFELLIAVLLCFKRSRLPGLYASSALMAAFTVYIFLILNYSDFVPCSCGGILEKMGWTEHLIFNCACVVMADLAIAAGYPLAPLLSNAVHSEEERNQNYRQRRAGVRALALSVAAALAVPAGLMTALFFSSEHVMTKENNFTRRFPHHPILEQQSYDLKVNSYYFAGHHDGTVYLGNLSSPFRLFTIDRHHKKMDTLNLIPATNHRFRNLRYVLQEKILYAYDGTVPVIYASSIDSLKNPLFEMSVNDVYFDQMVPLSPSEYVMRVKDKATQRAALASLSLFADPKVRIINSVLTRKADGGFDADGRLLYDAASDHIYYLFYYRNQILQFDKHLKVTARMKTIDTISTSQIQTTVLKDGSKKMSAPPVMVNKEMTAYKGLIFNRSNLTGKHEPKEMWKRNAVVDIYTTAPAGYWGSMYVQNRGKNAMSQMLVTDSYFYILSGNEIVRYRFAQTLTENFIKGGSRKPVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P4</accession>
    <name>C6X5P4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ordered locus">FIC_01284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806017.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01284"/>
    <dbReference type="EnsemblBacteria" id="ACU07732">
        <property type="protein sequence ID" value="ACU07732"/>
        <property type="gene ID" value="FIC_01284"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01284"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_10"/>
    <dbReference type="OMA" id="RAITWWM"/>
    <dbReference type="OrthoDB" id="776861at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="224" mass="25098" checksum="8FC42587AFC76FD0" modified="2009-09-22" version="1">MRKPVIAIDGYSSTGKSSISKIIAKNLGLVHMDTGALYRGVTYYAINHCLDSAGNIDLPQLLSKLNSITLEFRNVDGELEPFLDGQNISQQIRGKDISAHVSFIACQREIRDFLMGTQRSIAAEGGVILDGRDIGTVVLPNADYKFFLTASVEERTKRRFLELQKMGIEITEEEVKTNLVTRDRIDSERDIAPLKKADDAILIDNSNLTKRETIDLMLTYIKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q9</accession>
    <name>C6X5Q9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <ecNumber evidence="4">2.3.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806032.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01299"/>
    <dbReference type="EnsemblBacteria" id="ACU07747">
        <property type="protein sequence ID" value="ACU07747"/>
        <property type="gene ID" value="FIC_01299"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01299"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_3_10"/>
    <dbReference type="OMA" id="RSQMFAK"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="45"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="424" mass="47195" checksum="37104A896689F190" modified="2009-09-22" version="1">MTDIFERLRQNPGPLGQFADYAEGYFVFPKLEGPIGPRMRFQGREVVFWSANDYLGLCNHPEVLEADAKAAAEFGMFYPMGARAMSGETDQHQQLERELAEFVRKESAYLLNFGYQGMVSTIDALVSRHDVIVYDADSHACIVDGVRLHMGKSFTYKHNDIASLEKNLARATKVAEENGGGILVVTEGVFGMRGMQGKIKEICDLKSKFDFRLLVDDAHGFGTLGTTGAGAGEEQGCQDQIDIYFSTFAKSMAGFGAFIAGDKEIIRILKYNLRSQVFAKSLTMPMVIGGLKRLDLLRSRPEIKAKLWENVNKLQDGLSKRGFNIGGTNTCVTPVMMQGSTVEATMLVKDLRENYGIFTSVVIYPVIPKGMILLRLIPTASHTDAEINETLDAFDAIHDKLTSGFYKEQEQKLLEEKNLNFKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T4</accession>
    <name>C6X5T4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806057.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01324"/>
    <dbReference type="EnsemblBacteria" id="ACU07772">
        <property type="protein sequence ID" value="ACU07772"/>
        <property type="gene ID" value="FIC_01324"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01324"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_10"/>
    <dbReference type="OMA" id="SYKARIM"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="214" mass="24427" checksum="E5AA0F17F970C51F" modified="2009-09-22" version="1">METIKIAIVDDHKLVSKAIENMISYNPNFDVIMNSANGQDFLDQLRTAQDFPDVVLMDINMPIKNGIETTAELTKEFPQLKVIALTMEDHEGTIIKMLKAGAKGYLLKDMSPDILFDAIDIVHKKGIFYTDLVTQSLLKIKTEEKFMETLSDTLKDRELEFIRLACSELTYREIADQMFVSPRTIDGYRDSVFVKLNVKSRVGIVLFAIKHNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T5</accession>
    <name>C6X5T5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="5" type="ordered locus">FIC_01325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">2 residues (Tyr-56 and Arg-59) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806058.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01325"/>
    <dbReference type="EnsemblBacteria" id="ACU07773">
        <property type="protein sequence ID" value="ACU07773"/>
        <property type="gene ID" value="FIC_01325"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01325"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_10"/>
    <dbReference type="OMA" id="SMQVYPA"/>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="230" mass="25857" checksum="B88D2A969BDDDCBD" modified="2009-09-22" version="1">MKYRKKLVVLSGAGSSAESGVQTFRDSDGLWENHRIEDVASPEGFARNPQFVLDFYNARRRQLDLVQPNDAHRILAKLQDVLEVVIITQNVDDLHEKAGSQNVIHLHGELRKARPVDSLTDIRIWNKDLNIGDLAEDGTQLRPHIVWFGEMVPEMERAVETAQTADYFLIVGTSMQVYPAAGLVSYVPESCEIFGIDPNPDSQFSAGATFFNTTATEGMRLFKEKLLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V0</accession>
    <name>C6X5V0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806073.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01340"/>
    <dbReference type="EnsemblBacteria" id="ACU07788">
        <property type="protein sequence ID" value="ACU07788"/>
        <property type="gene ID" value="FIC_01340"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01340"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_3_1_10"/>
    <dbReference type="OMA" id="DAADECT"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="247" mass="28689" checksum="3C0BE61D1BE80DF7" modified="2009-09-22" version="1">MKADDSKNKQSLEDLLNTREFVEHISVDCAIFGLDDGVMKVLLLKYHEVDMWSLPGGFVFTDEDLDEAAARVLFERTTLSNVFLEQFHTFGGKNRTDNNTHQTLLKTKNIEVPRDHWIFQRFITVGYCSLIDFSLADVFPDTVNETCAWFDVTKLPAMAFDHDRIIEKGLAHIRKNIDTQIVASKLLPEKFTMKQLQTVYETVLGEKFRRNNFQRKILGFNSLERLEKFFDGSANKAPYLYRFVDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V1</accession>
    <name>C6X5V1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806074.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01341"/>
    <dbReference type="EnsemblBacteria" id="ACU07789">
        <property type="protein sequence ID" value="ACU07789"/>
        <property type="gene ID" value="FIC_01341"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01341"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_10"/>
    <dbReference type="OMA" id="AAMDCYD"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="136"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="240"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="393" mass="43358" checksum="4890FD091C775930" modified="2009-09-22" version="1">MSYYPLTSIPDYFLMDGLLSEEHKLIRQSVRDWVESFVMPKIDGAAQDHTDIPGLMQELGKIGALGPYISEEYGGAGLDQISYGIIMQELERGDSAVRSAASVQSSLVMFPINEFGSEEQKRKYLPKLATGEMIGAFGLTEPNHGSDPGAMETHFEDKGDHYLLNGAKMWITNAPLCDIAVVWAKNEQGKVQGMIVERGFEGFTTPETHNKWSLRASKTGELVFNDVKIPKENILPNVIGLKGPLSCLNSARYGISWGVIGAAIDCYCTALQYSKERKQFGKPIASFQLQQKKLAEFLTEITKSQLLCLQLGNLKNDHKASPAQISMAKRNNVKMAIEIARESRQMLGGMGIMGEFPMMRHAANLESVITYEGTHDIHLLITGMDVTGINAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V4</accession>
    <name>C6X5V4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ordered locus">FIC_01344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806077.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01344"/>
    <dbReference type="EnsemblBacteria" id="ACU07792">
        <property type="protein sequence ID" value="ACU07792"/>
        <property type="gene ID" value="FIC_01344"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01344"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_2_2_10"/>
    <dbReference type="OMA" id="AKINVIS"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="211" mass="23890" checksum="ED1DD26DAF819241" modified="2009-09-22" version="1">MNAELIDKYFPELSAEQKNQFEKLDGLYREWNEKINVISRKDMDSLYEKHILHSLGIAKVMQFAPGTQVLDIGTGGGFPGIPLAILFPQVQFTLIDSIGKKITVVKEVSEGVGLKNITAVHGRAEDLKGKFHFIVSRAVTQMPVFLRWLKGKFEKEQINQKHNGVLYLKGGDLSEELSGLNTEIFELKNYFEGEFFDTKKVVYLSKGNFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V6</accession>
    <name>C6X5V6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-ribbon protein, possibly nucleic acid-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806079.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01346"/>
    <dbReference type="EnsemblBacteria" id="ACU07794">
        <property type="protein sequence ID" value="ACU07794"/>
        <property type="gene ID" value="FIC_01346"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01346"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073076_2_0_10"/>
    <dbReference type="OMA" id="EHCGRIL"/>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="259" mass="30229" checksum="9CA9DE855F053AC3" modified="2009-09-22" version="1">MAKKTVEISVEDKLRALYDLQIIDSRLDEIRNTRGELPIEVEDLEIEIEGLEKRAEKFQAEIKEQNDEINNKNEVISHSKTLIDKYKAQQDNVRNNKEFEALDKEIEFQELEIQLADKRIKEFSAKIAHKNETFEELNNKISELKSHLKFKKEELENLVSETQKEEDFLIEKSSEFAKNIDERLLASYQRIRTNSPTGLAVVGLERGAPKGSFFTLPPQKQMEIAQRKKIIIDEHSGKILVDDDLVNEENEKMKEIIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X666</accession>
    <name>C6X666_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01456"/>
    <dbReference type="EnsemblBacteria" id="ACU07904">
        <property type="protein sequence ID" value="ACU07904"/>
        <property type="gene ID" value="FIC_01456"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01456"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345387_0_0_10"/>
    <dbReference type="OMA" id="RNSFETM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043741">
        <property type="entry name" value="DUF5686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18939">
        <property type="entry name" value="DUF5686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="831" mass="95396" checksum="B5688354EAEDAF74" modified="2009-09-22" version="1">MLMQLILQTNSSLDLSIFANMKKNFLLFIFSFLFLTLSAQSKITVLSAGDGAPLGNATVTCDAKILGRTNAQGVLNFRTKCKKVDVKAPGYYEDEAVVDRVMEISLSKTDPKTQSIEAVAINDKSDPLALAILQKVNDNYKNNSPQSLDSYSFKSYEKISLDIDEDSIKHYSNYLGKRLDSLKSLPPQEISDSKKKDSVESVNVNKLMAQSKMFLWERASEYLYSARYGEKINILDNRVAGLKEPIYEMMTLRSNRSRVPREIREENRTLYRFFLTDSIEIDGRKNYVIRFRQVDNKQPVNRRKYNGYLYVDAQTYGLKKIESNSAKKSEGTITSIWKPIENKWFLSKENLKIKMGSTAFNKGETPDKGDKKAQQKYGNYVFMVADYFDFKTPIEENKKDFSGYTMSVQNADGKTLDVFRTDSLSAREKLTYEKIDSVGKKYKLDQKINGFTGLIKGKLRVGQVDFDASQIIKYNLYEGIRLGVAAKLNERFNPYISPDAYIAYGFKDHNWKYGVGLDVKTTLNKNSFFRAEYYNDVVAAGRFNETLWNFKMKIMNSGIDMKNDRFYRYDGFKIAFEHDVNNALTFNISGKKDNEESTFDYSFMDLGQKFENVAAKLTLKYAPRSKNIMTPSGKFTYEQSFPEFYVNFEQGLQTLGGDLNYSRFDALAQHNFKTKAGVTGIRVYGGLITGEAPIWHHFAMNGLGNRSGESFNYNLTSFLGFATMESGKYYNDKFVGYYFTHRIPYYFRTFGKNVSSFDVVYRGITGDMKNPEHHAFAFEKLDHLYQEIGLESNNFLGTPFNLGFFYRVGYYSTPTFKENFGVQLKLNFLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C3</accession>
    <name>C6X6C3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806246.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01514"/>
    <dbReference type="EnsemblBacteria" id="ACU07961">
        <property type="protein sequence ID" value="ACU07961"/>
        <property type="gene ID" value="FIC_01514"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01514"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093157_0_0_10"/>
    <dbReference type="OMA" id="FNIINIE"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="29019" checksum="552D2680C20AB893" modified="2009-09-22" version="1">MILLTFNILNNAGDFKKNHFLDDAEILNITVDHTSAILSILENHDIKATFFVAVQLVDKTLTLIKKIVGKGHEISLYNDGSTLPQIQNAKRTVEDLIGKTVRGIRQKEIRVPIEKLKELGFSYISNIERSSMFFPLKRLKTNTEISLEQGLHVIPEGISPYTQIPYNEFVFQLLPLKIYEQMISETLENNDFVIIYLHTSQFTDPDKFGFDIPLHRRYNSGKKMDDKLSEFLRWVNKKEFSCTRIKDYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E9</accession>
    <name>C6X6E9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nhaA</name>
        <name evidence="8" type="ordered locus">FIC_01540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cell inner membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806272.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01540"/>
    <dbReference type="EnsemblBacteria" id="ACU07987">
        <property type="protein sequence ID" value="ACU07987"/>
        <property type="gene ID" value="FIC_01540"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01540"/>
    <dbReference type="eggNOG" id="COG3004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015803_1_0_10"/>
    <dbReference type="OMA" id="MGLMLRC"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="394" mass="42967" checksum="DE5661E9F63B8992" modified="2009-09-22" version="1">MLITDYFKKFLHSSQSSGILLICCVAVSLLIANSALAEGFQNILNKEIGTDVFGLNYPVSIWINDGLMVVFFLLVGLEIKREIVEGELSSFKSASLPIVAALGGMIVPALIYIFFNQDSEYAKGWAIPMATDIAFSLAILSMLGKGVPLSLKIFLAALAIVDDLGAIVVIAMFYTDQIHWNYLALSGAMVAFLVVLNFLKFKKHIFYIIPGLFLWYFMHHSGIHATIAGVLMAFTIPTNISTTEISPLEKMEQKLHLPVNFLVMPLFALANTNITFKEGMVEGLFSSLGYGIVLGLVIGKLVGINLFSWIFIKLKISSLPDQSTWPQMLGTGLLAGIGFTMSIFIALLSFKGHAEIQDEAKFAVLIASVFSGVTGFLILKYLGKKESKPAAANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H7</accession>
    <name>C6X6H7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 3</fullName>
            <shortName evidence="5">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfC</name>
        <name evidence="7" type="ordered locus">FIC_01568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806300.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01568"/>
    <dbReference type="EnsemblBacteria" id="ACU08015">
        <property type="protein sequence ID" value="ACU08015"/>
        <property type="gene ID" value="FIC_01568"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01568"/>
    <dbReference type="eggNOG" id="COG4108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_2_1_10"/>
    <dbReference type="OMA" id="GFVFKIH"/>
    <dbReference type="OrthoDB" id="164090at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="533" mass="60738" checksum="83805A429588BBB6" modified="2009-09-22" version="1">MSALLKEIERRKTFGIISHPDAGKTTLTEKLLLFGGAIQEAGAVKSNKIKKGATSDFMEIERQRGISVATSVLAFEYRDHKINILDTPGHKDFAEDTYRTLTAVDSVIVVIDVAKGVEEQTEKLVKVCRMRNIPMLVFINKLDREGKDAFDLLDEVEQKLGLTVCPLSLPIGMGADFQGIYNIWEKNIQLFLEEKKQRVGEAIRFDDINDTKIDEVIGEKAAATLREELELVESVYPEFNREDYLNGDLQPVFFGSALNNFGVRELLDAFIDIAPKPQPKESETRIVKPEEKDFTGFVFKIHANMDPKHRDRLAFVKIVSGTFKRNENYLLVRENKKMKFSSPNAFFADKKEVVDESFPGDIVGLHDTGNFRIGDTLTGGEKISFKGIPSFSPEHFRYINNDDPLKAKQLAKGIDQLMDEGVAQLFTMDMNNRKIIGTVGALQYEVIQYRLEHEYGAKCTYEPLSIHKACWIEADEKSEEFKEFARLKQRFMAKDKYGQPVFLADSSFTIHMTQEKFPNVKLHFISEFRTQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I6</accession>
    <name>C6X6I6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TPR_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01577"/>
    <dbReference type="EnsemblBacteria" id="ACU08024">
        <property type="protein sequence ID" value="ACU08024"/>
        <property type="gene ID" value="FIC_01577"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01577"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3135931_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041656">
        <property type="entry name" value="TPR_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12688">
        <property type="entry name" value="TPR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPR_5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="49" mass="5494" checksum="89AE85867EE46440" modified="2009-09-22" version="1">MDDAVNAFLALSLSSNNEDKKALSLALESLSKHLPRYNKSLLNYSRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I9</accession>
    <name>C6X6I9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulf_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806312.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01580"/>
    <dbReference type="EnsemblBacteria" id="ACU08027">
        <property type="protein sequence ID" value="ACU08027"/>
        <property type="gene ID" value="FIC_01580"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01580"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037802_3_0_10"/>
    <dbReference type="OMA" id="VISWFRI"/>
    <dbReference type="OrthoDB" id="1518604at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="58"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="166" mass="18903" checksum="854F2A7A3EE9E042" modified="2009-09-22" version="1">MSQNITPQEDLELRSLDTMCVNESRLQHQWYHNLKYLVMGILFGILFIKAEVISWFRIQEMFRLHSFHMFGIIGSAILVAMISIFLIKKFKIKTVYGEEIIFHKKEFNKGQIYGGLIFGFGWAITGACPGPLFAQIGTGATVIVVTLLSAIAGTWVYGKFRDKLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG3</accession>
    <name>C6WZG3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/calcium exchanger membrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00020"/>
    <dbReference type="EnsemblBacteria" id="ACU06498">
        <property type="protein sequence ID" value="ACU06498"/>
        <property type="gene ID" value="FIC_00020"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00020"/>
    <dbReference type="eggNOG" id="COG0387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050648_0_0_10"/>
    <dbReference type="OMA" id="AAVMITC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="40"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="223"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="367" mass="39371" checksum="6CEE40D869C63058" modified="2009-09-22" version="1">MYNCGNPLFMKFKKALQWHVIFPIIAAVFYLGGFLTDTVVANILGGILLFATVLAAVHHAEVVAHKVGEPYGTIILAICITILEVGLIISFMLSGGEGALTYARDTVFAAVMLILNGILGVCIWVGSRKYKEQFFMRSSATTYLVSLVAILVLTLVLPNYTSSMVGPYYSTSQLIFVSLSCLVIYAAFLMFQTVRHRNYFIVTEADQTTHEADPPTVTKTLLSLLLLVICLAVVIFMAKGLSPVIEDFVENAGAPRALVGVIIATVVLLPEGFAAVRAAAKNQIQTSINLGLGSALASVGLTIPAVSVVCVTMDIPFVLGIDTKSVILLALSVFTVMLSLSRGKTNHLYGTVLLVNLAAYIFTVIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH3</accession>
    <name>C6WZH3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781655.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00030"/>
    <dbReference type="EnsemblBacteria" id="ACU06508">
        <property type="protein sequence ID" value="ACU06508"/>
        <property type="gene ID" value="FIC_00030"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00030"/>
    <dbReference type="eggNOG" id="ENOG5032WM2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1623915_0_0_10"/>
    <dbReference type="OMA" id="NMNIGTN"/>
    <dbReference type="OrthoDB" id="2003768at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="159" mass="17258" checksum="E4F2B34EC5CC3940" modified="2009-09-22" version="1">MNKFLLFFAFFIAQNVFSQVTISGNRLIKDGQEYKFSKYRDVFTNSEAEVAFSKARTNSTVGQIFAYAGGFGIGFGLIPALQGNKTETRNGMVYKRDASSAWTVVGIGAGLVAIGIPFAIASNKNADKALKLENGEVTAFQPYFKLETAGNGMAVSYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM1</accession>
    <name>C6WZM1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ordered locus">FIC_00080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00080"/>
    <dbReference type="EnsemblBacteria" id="ACU06556">
        <property type="protein sequence ID" value="ACU06556"/>
        <property type="gene ID" value="FIC_00080"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00080"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_1_10"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="48"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="188"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="437"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU06556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="508" mass="57854" checksum="17CAEB3D9B829E95" modified="2009-09-22" version="1">MKYKIGLLHFQLILNFKPPKIYKVQEKYIDENKQGEAFAIAEKPQNSKKLFLESYGCQMNFSDSEIVASILSKQGYNTTLNHEEADLILLNTCSIREKAEQTVRMRLSQFKNLKKERPNLTVGVLGCMAERLKTKFLEEEQLVDLVVGPDAYRDLPNLLKETDSGRDAINVILSKDETYADINPVRLGGNGVTAFVTITRGCDNMCTFCVVPFTRGRERSRDPHSIVEECKTLWENGYKEITLLGQNVDSYLWYGGGAKKDFKNASEMQQLTAIRFAQLLEMVAVAVPEMRIRFSTSNPHDMTVDVFEVMAKHDNICKYVHLPVQSGSDRILEKMNRQHTRAEYLNLINRAKEIVPEISFSQDMIIGFCGETEEDHQLTLSLMREVEYDYGYMFAYSERPGTPAHRKMEDDVPADVKQRRLAEVIALQGELSRKRMQGYAGRMHEVLIEGTSKKNQNQWKGRNSQNAVCVFDKLEDQKLGDIVTVFVHGNTQGTLLGTTVNEVSVEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ5</accession>
    <name>C6WZQ5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00115"/>
    <dbReference type="EnsemblBacteria" id="ACU06590">
        <property type="protein sequence ID" value="ACU06590"/>
        <property type="gene ID" value="FIC_00115"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00115"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181423_0_0_10"/>
    <dbReference type="OMA" id="AKCHKLF"/>
    <dbReference type="OrthoDB" id="1797002at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="109" mass="11967" checksum="04A1FE294CB303DC" modified="2009-09-22" version="1">MTPSAHFHTTKKNRSLKNLIITAIAGLSFLASCTTKPAVVEGSETDHVETLAAGKTIYENSCARCHELPNPTAHSAQDWVGIMNWMAPKAKLNDEQHALVYDYIVSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT3</accession>
    <name>C6WZT3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type cbb3 cytochrome oxidase biogenesis protein CcoG, involved in Cu oxidation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781765.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00143"/>
    <dbReference type="EnsemblBacteria" id="ACU06618">
        <property type="protein sequence ID" value="ACU06618"/>
        <property type="gene ID" value="FIC_00143"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00143"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032118_2_0_10"/>
    <dbReference type="OMA" id="EMVFRRI"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014116">
        <property type="entry name" value="Cyt_c_oxidase_cbb3_FixG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032879">
        <property type="entry name" value="FixG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13746">
        <property type="entry name" value="Fer4_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11614">
        <property type="entry name" value="FixG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02745">
        <property type="entry name" value="ccoG_rdxA_fixG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="482" mass="55591" checksum="8C3F79ADB08F50C8" modified="2009-09-22" version="1">MIEDQNFRGGQGQVVDAETFRDSVGTMDQSGKRKWVYPRKPKGRYTNYRTVVAWILLAIFFALPFIRINGNPFLLLNFVDRQFFIGGQSFYLQDFFILALGAITSIVFIILFTVVFGRIFCGWICPQTIFLEMIFRKIDYMIEGDRNKQMKLDRQEWNAEKIWKRSLKWFIFIIISLIITHWMFMYIVGYEGVFDMVKEGPLTNFTSFLVMILFTAAFYFTFAWFREQVCTLVCPYGRLQGVLIDKQTINVYYDFKRGENRSKWRKGEDRRAEGKGDCIDCNQCVVVCPTGIDIRDGQQLECVNCTACIDACDEVMAKVGLPLGLIRYATEDEIEKETSFKFTGKMKAYSVVLLLMVAFLGFLLTNRGSMEAKFIKPAGSSFFVRDGKINNTYNYTFLNKSSKDQLVTIKIIEPAHGQITLSSNNKILLKKDAMTKGTVNISFPENEIKLSKQNVTIGVYDQSGELLDSFETYFEGPFKLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT9</accession>
    <name>C6WZT9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781771.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00149"/>
    <dbReference type="EnsemblBacteria" id="ACU06624">
        <property type="protein sequence ID" value="ACU06624"/>
        <property type="gene ID" value="FIC_00149"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00149"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_0_3_10"/>
    <dbReference type="OMA" id="VLCRDFG"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="237" mass="26708" checksum="70BF1C6042C245EE" modified="2009-09-22" version="1">MSLEKQKLIEENLKKVFNDESFKEMLSEEDFAHYISVKQQLKFRKGETIFEDGGTPNGVYFLNKGTAKLSKQGVYGKEHILRFIAEGDLIGYRSLLCGEQFQARAEAMTDVEAIFLPSDVFLHLLEVGPRLSFVMLQKIAFELGESSNTVTVLAQKTVRERLAEILLLLEQKLGTDPEGFIKITLTREEIANLVGTATESAIRLISEFKQDGLIEADGRSLKILNREKLIKLGHVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV5</accession>
    <name>C6WZV5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">xerC</name>
        <name evidence="14" type="ordered locus">FIC_00165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00165"/>
    <dbReference type="EnsemblBacteria" id="ACU06640">
        <property type="protein sequence ID" value="ACU06640"/>
        <property type="gene ID" value="FIC_00165"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00165"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_10"/>
    <dbReference type="OMA" id="QAFWYLI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="110"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU06640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="302" mass="35295" checksum="78DF99F2FAAD6215" modified="2009-09-22" version="1">MMTWTEKIKDFESFLKYERNFSDNTLDAYLRDIRKLSDYAEFHLDGTGPLEISYENIQEYLFQLSKQKFSERSQARWISSIKAFFKYLAEDEAREDNPTTLLESPKLGLYLPDTLSFEDVERIIKAINISTDLGRRNQCMIEVLYGCGLRVSELIDLKISNINFKELYLKVDGKGDKSRFVPLATYTAKLIKEYIQEIRSKYKINKKCEDVLFLNSRGSAMSRVIVFIIIKELTEKAGINKKISPHTFRHSFATHLLQNGADLRYIQEMLGHSSITTTEIYTHLKNEELRDVILNFHPRNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY3</accession>
    <name>C6WZY3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00193"/>
    <dbReference type="EnsemblBacteria" id="ACU06668">
        <property type="protein sequence ID" value="ACU06668"/>
        <property type="gene ID" value="FIC_00193"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00193"/>
    <dbReference type="HOGENOM" id="CLU_3381966_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="33" mass="4046" checksum="CABC53A728F602D4" modified="2009-09-22" version="1">MPLPPVEYRHHYDSKKGKNKFLPPERLKINFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X007</accession>
    <name>C6X007_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781839.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00218"/>
    <dbReference type="EnsemblBacteria" id="ACU06692">
        <property type="protein sequence ID" value="ACU06692"/>
        <property type="gene ID" value="FIC_00218"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00218"/>
    <dbReference type="eggNOG" id="ENOG5032Z11">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142255_0_0_10"/>
    <dbReference type="OMA" id="REHNENR"/>
    <dbReference type="OrthoDB" id="2001049at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973527" evidence="1">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="155" mass="17990" checksum="C61AD747ED0BA22E" modified="2009-09-22" version="1">MARLKCYYILLLFVFSCSAEKINLSPLGENSLGGSFDKAYTPLSDRKNLIVYSSEITNLIASFPKFRNDAVNTEVKLIKSHLRDYVDALKSYNVIETEKSYARFERSYKKLQKLRKYLNADEDEVLNRYLVRLKINMNHLQSNLPQDSLSSSFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X051</accession>
    <name>C6X051_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional deaminase-reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781883.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00263"/>
    <dbReference type="EnsemblBacteria" id="ACU06736">
        <property type="protein sequence ID" value="ACU06736"/>
        <property type="gene ID" value="FIC_00263"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00263"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_3_10"/>
    <dbReference type="OMA" id="YGRITYQ"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="20875" checksum="386CE04677B70549" modified="2009-09-22" version="1">MRKITAAINMTLDGYCDHTAISPGAEIHQHYTELLRNADTILYGRITYQLMEFWKTLAEKPSGVQSMDDFAEVMSSITKIVFSHTLKNVDWDSAQHATQSLESEVRKLTQQPGKDILVGSRSLIMQLIQLNLLDELQLMVHPVIAGSGLPLFEQISKSTNLELADTKRLGDAVILYYTFPLRHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X080</accession>
    <name>C6X080_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781912.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00298"/>
    <dbReference type="EnsemblBacteria" id="ACU06765">
        <property type="protein sequence ID" value="ACU06765"/>
        <property type="gene ID" value="FIC_00298"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00298"/>
    <dbReference type="HOGENOM" id="CLU_2665706_0_0_10"/>
    <dbReference type="OrthoDB" id="2091568at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013406">
        <property type="entry name" value="CHP02574_addiction_mod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09720">
        <property type="entry name" value="Unstab_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="75" mass="8628" checksum="00ED58E92537BF92" modified="2009-09-22" version="1">MNITIEQITDKLKALPEHALERVWGYVEALSENASGKDIPGWQQTIVAERLENYEQNPDSAVEIDEVLRELEKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D8</accession>
    <name>C6X0D8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781970.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00356"/>
    <dbReference type="EnsemblBacteria" id="ACU06823">
        <property type="protein sequence ID" value="ACU06823"/>
        <property type="gene ID" value="FIC_00356"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00356"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_3_0_10"/>
    <dbReference type="OMA" id="FVMRTWM"/>
    <dbReference type="OrthoDB" id="1543624at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="32"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="32411" checksum="AEB8647A6830C7EF" modified="2009-09-22" version="1">MNKESHPTYYIHSKQSVFSLNLKEVWDYRDLLLMLVKRDFITFYKQTILGPLWFIVQPLLTTAIYVVLFGNIAKLSTDGMPQILFYLSGITVWNYFSESLTKTSTVFTANAGMFGKVYFPRLIMPLSIVASSLMKFAVQFAIFIVFLLYYVIFTDAVQPNAWMLLTPVLILLMAMFALGMGMIFSSLTTKYKDLSFLLSFGIQLFMYITPVVYPVSALPEKYRFLLYFNPLSPIFECFRYAFLGSGSFDLFNLLWSALFIVIILVAGTVIFNKVEKSFMDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I5</accession>
    <name>C6X0I5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tilS</name>
        <name evidence="9" type="ordered locus">FIC_00404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782018.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00404"/>
    <dbReference type="EnsemblBacteria" id="ACU06871">
        <property type="protein sequence ID" value="ACU06871"/>
        <property type="gene ID" value="FIC_00404"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00404"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_1_10"/>
    <dbReference type="OMA" id="QQYGMNA"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="359"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="434" mass="49586" checksum="ADCA46576F0A82E6" modified="2009-09-22" version="1">MLTQATFDAQLLNLKPDPESARYLLAVSGGVDSMVLLYLFSHSNLEFEVAHVNYRLRGVDSDADQRIVEEFCAKHHLTLHVYEVGDHDGKPANSVQLWARELRYGFFRKIQIQSDLQYIVTAHHLNDQLETFIINLSRASGLNGLSGIPSNENGILRPLLNFTKNDIYDFAAQRSIQFGEDVSNSKNDYLRNFIRNEIAHRLLETNTGFLPNFSRTIHYLDQAKDFIHEQISAVEDEIISHSDDSILIDREKFGQQSDFVKFEILRKLGFDSATEVQKIVAAEKGKCFKSADYILTVDRNHLILNAIDSQEFEPKKIIITSDALKNPASISLRTFLPAEILPQPDFSWEFDADQLQFPLKLRHRLAGDVFFPVGMAGSKKVAKFFKDEKIPIFAQRKMWLMCDGDDNILGVIPIRQDRRFAADHNAKNIISVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I7</accession>
    <name>C6X0I7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782020.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00406"/>
    <dbReference type="EnsemblBacteria" id="ACU06873">
        <property type="protein sequence ID" value="ACU06873"/>
        <property type="gene ID" value="FIC_00406"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00406"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_4_0_10"/>
    <dbReference type="OMA" id="RGMRPDG"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="215" mass="25117" checksum="2A438128D6148D22" modified="2009-09-22" version="1">MSFFEENCQEMDRYLENHASAEPDILKRLRRETYQKTTQPHMISGYQQGRLLTIISKMLQPRNILEIGTFTGYATLCLAEGLATDGKITTLDINEELAYLPRKYFAESEFSQQIYFKLEDAKQYLVKTDEIFDLVFIDADKENYVEYFKLIEPKLKSGSVVMFDNVLWYGKVLEDSPKQKSTQKIKELNDLVAAHYDFENLILPLRDGVNLIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I8</accession>
    <name>C6X0I8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NLP/P60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782021.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00407"/>
    <dbReference type="MEROPS" id="C40.009"/>
    <dbReference type="EnsemblBacteria" id="ACU06874">
        <property type="protein sequence ID" value="ACU06874"/>
        <property type="gene ID" value="FIC_00407"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00407"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_13_2_10"/>
    <dbReference type="OMA" id="NAPYLWG"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041382">
        <property type="entry name" value="SH3_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18348">
        <property type="entry name" value="SH3_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="105"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="235" mass="26686" checksum="EA49465CAE257EED" modified="2009-09-22" version="1">MEKAVCSVSVAPLRAENSHRSEMVSQLLYGETVEILETAANFTKIRMDYDQYEGWVDSKQIKSVDATHRKTTVLKRPFDTASFPEGNILLSIGSEYEVSDLIESSTPCEKLIDTALLFLNVPYLWSGRSFFGIDCSGFVQLVYKVHGFKLPRDAYQQAEHGTVLDFIEESEPGDLAFFDDSEGKIVHVGIMLADQQIIHAYGKVRIDTLDSLGLFNKDLNRHTHKLRFVKRMQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P7</accession>
    <name>C6X0P7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00471"/>
    <dbReference type="EnsemblBacteria" id="ACU06933">
        <property type="protein sequence ID" value="ACU06933"/>
        <property type="gene ID" value="FIC_00471"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00471"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_10"/>
    <dbReference type="OMA" id="TMTVAVR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="188"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="449" mass="50835" checksum="1B48E711A8BC1E26" modified="2009-09-22" version="1">MAIFAAQKTPLETQELIFNPADIAETLSELPVKERVLAFLKVPKQYKAEVFSHLEPDFQEETIRSIGSEDVSEILNAMTPDDRTALFEDFPDELIKYSINHLNPQERRIALKLLGYDSDSIARLMTPYYIQIRKEWTVKRCLQQIKKVGKKMETMNHLYVVDERNQLIDDIAIGSLLLAEEDTLISDITDNHFVAITTTTSKEDAVQYFEKYDRTALPIVTEAGVLVGIVTIDDILDQIEQQNTEDIQKFGGMEALDDPYRQTHWFEMIKKRGFWLILLFFFQLLTASAMGYFEDEIQKAVVLTLFVPLIISSGGNTGSQAATLIIRAMALQEITVKDWWIVIKKEVITGLFLGGILGILGFVRIWVWQVLGWFDYGEYWAFIGLSVGLSLTMIVMWGTLSGSMVPFVLKRFNLDPATSSAPFVATLVDVTGLLIYFSLAGLLLTGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Q2</accession>
    <name>C6X0Q2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Immunoreactive 84 kDa antigen PG93</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782085.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00476"/>
    <dbReference type="EnsemblBacteria" id="ACU06938">
        <property type="protein sequence ID" value="ACU06938"/>
        <property type="gene ID" value="FIC_00476"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00476"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018865_0_0_10"/>
    <dbReference type="OMA" id="WDTTAFG"/>
    <dbReference type="OrthoDB" id="244703at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970517" evidence="1">
        <location>
            <begin position="19"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="754" mass="81593" checksum="C71AB458DEF717FE" modified="2009-09-22" version="1">MKKTVLFILFLFSLQLSAQVISSTRWTDLFSYNNVIAVREDDGKLIAATENGIFYYTPASGEVTKLSKANGLHEVKISAFDYNPETKIGLVGYLNGSMDVITPEGITYVVDIPIATGYNGNKKINHISITGDLAVVSVGYGVSIFRLDKKEFADSSFFVTGGGVYEACREAVIKDNVVYAATSTGLKSHEINTTFTIYSTWTPLAAGNMTQVAGGSVVAFSDAATVRFGSGATFAALPQGFSAIQDVVVTPENIIVTESSAVSVFGISGNFIRSYNAGEALNTGTYSNSVIYAGTKTSGIKNETGNLLKPDGPYNNTSYKISLLNDNIWISTGNRTNRLNDAAPHPMNLGFYYFTGTEWIYPSFFKTSGFGFNVLDAVANPSDITEVFFTNFIPQASQGVYKMKFNSASKDYEFVKVYKTGLDVYHGRPVGLAFDDKNNLFGTVAFLDTENPDGNAGLMAYDRGSDSFKYKSLKITAATQKPVIADGFIWTPLPRLNALAAVDYKNTLSFADDEISIVARQNGLPSNSEGTLGIAIDKTGDAWIGTDNGLRVLSSASSNVKNNPTVEPIIIEENGIGEELFRDSSILQIEVDSGNQKWVSVNGGGVFYLSSTGEQTIRHFTKENSPLPSNSVTDIKVDNKSGKVYFATLDGVMVYQGDVLDVTENFGDVLVYPNPVVYSRYKGNVRIRGLAEKTNIRITDAAGNLVHQAVSRGGYYEWNLNNQRGVRVASGIYFVLMTNADGTDTATAKIGVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0W1</accession>
    <name>C6X0W1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="7" type="ordered locus">FIC_01629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806359.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01629"/>
    <dbReference type="EnsemblBacteria" id="ACU08074">
        <property type="protein sequence ID" value="ACU08074"/>
        <property type="gene ID" value="FIC_01629"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01629"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_6_0_10"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="370" mass="42509" checksum="205490A4E5A2EF2A" modified="2009-09-22" version="1">MINSDLIKDTNSRIADLYKYLQIEKKKIEISNDEEKTLSPEFWDKPKDAEIFMKQLRSKKKWVTDYEEIFSRLEDIQVLMEFAKEDPDSEKELDEAFPVLLEKIEDLEFKNMLSNEGDELSAVLQITAGAGGTESCDWASMLMRMYTMWAEKQGYKLRELNYQEGDVAGIKTVTLEIDGEFAFGYLRGENGVHRLVRISPFDSNAKRHTSFVSVYVYPLVDDTIEININPADISFETMRSSGAGGQNVNKVETAVRLRHAPTGIIIENSESRSQLQNKEKAMQLLRSRLYEMELEERMKARNEIEAGKMKIEWGSQIRNYVMHPYKLVKDVRSGHETSDVDAVMNGELTPFLKAFLMSDGTSVVEDDFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X0</accession>
    <name>C6X0X0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hemin receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01638"/>
    <dbReference type="EnsemblBacteria" id="ACU08083">
        <property type="protein sequence ID" value="ACU08083"/>
        <property type="gene ID" value="FIC_01638"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01638"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034649_0_0_10"/>
    <dbReference type="OMA" id="YQSPTWY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970526" evidence="1">
        <location>
            <begin position="20"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="466" mass="50424" checksum="8F49CA83D852C7FE" modified="2009-09-22" version="1">MIKKSLTVLSISAAYLLNAQDISTLRNTAEVYSNSSLNGSAKYNAMAGSMGALGADYSVLNSNPAGIGVSIANEFSLTLGIESQQSASTLAGPTTNYKINNTDIGSAGGVVVFPLSPSSAWKFVNVGVSYSNQSLEDYIETPGNSNVSFEFRDENDVLLEDLALAGHAYNRYGNLSKTSIGVGGNYDNRIYVGAGLNFHNSVLDQYDSAAFSNSANVTTVFDKQYTPYSEAATGFSASVGVIGKINPNFRVGAALETPTWWNMERIYNEYENPVDGTYSEERRLSSPMKATLSAAYVANKNFALNVDYSLGLTKPKYKVYGDAETELNNFFDANSAALSEVKVGAEYRVQAFRLRAGYGFASSPYDSVSLNAFNETGNAGNRSFDNFIVGKRNTVGAGIGYDFRSFFIDAAYQHVNSEYTNPFLQGSEVDNTGYFSNAYIVNSGASAVSDVERKRDNFFITLGWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Z0</accession>
    <name>C6X0Z0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806388.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01659"/>
    <dbReference type="EnsemblBacteria" id="ACU08103">
        <property type="protein sequence ID" value="ACU08103"/>
        <property type="gene ID" value="FIC_01659"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01659"/>
    <dbReference type="eggNOG" id="ENOG5033BMY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2934082_0_0_10"/>
    <dbReference type="OMA" id="YIAYIAW"/>
    <dbReference type="OrthoDB" id="2055817at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="62" mass="7618" checksum="06C8D44552710FE0" modified="2009-09-22" version="1">MKKQLYIYMFLVVVFIAYNQFFEVQDERMHNLINILFASFLFLYIGYLAYLVLQRLKKGDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X105</accession>
    <name>C6X105_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806403.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01674"/>
    <dbReference type="EnsemblBacteria" id="ACU08118">
        <property type="protein sequence ID" value="ACU08118"/>
        <property type="gene ID" value="FIC_01674"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01674"/>
    <dbReference type="eggNOG" id="ENOG5032TV2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135453_0_0_10"/>
    <dbReference type="OMA" id="LWMRRRW"/>
    <dbReference type="OrthoDB" id="2016971at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="123" mass="13752" checksum="C9D183CD26CC0331" modified="2009-09-22" version="1">MQKIILLVFLVLFGSITLFMSSSVLFDWFGIRAKEGDFVPAVVWANWLCAILYLATAAAILKNRTWAKLPLIIALIILLAAYAYLFVHIRNGGLFETKTVDAMAFRIGFTILLLLATIKISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X118</accession>
    <name>C6X118_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">FIC_01688</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806416.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01688"/>
    <dbReference type="EnsemblBacteria" id="ACU08131">
        <property type="protein sequence ID" value="ACU08131"/>
        <property type="gene ID" value="FIC_01688"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01688"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_10"/>
    <dbReference type="OMA" id="WTCYVQV"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU08131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="502" mass="58077" checksum="AB4A0368660AA8B5" modified="2009-09-22" version="1">MSDNKLTRQTGAPVPDNQNVQTAGPRGPMLMQDFWFLEKMANFDREVIPERRMHAKGSGAFGTFTVTHDISQYTKANIFNTIGKKTDMFARFSTVAGERGAADAERDIRGFALKFYTDEGIWDLVGNNTPVFFFRDPMKFPDLNHAVKRDPKTNLRSANNNWDFWTLLPESLHQVTIVMSDRGIPKGYRHMHGFGSHTYSFINKDNVRHWVKFHFRTQQGIENLTEEEAIRVIGSDRESSQRDLFDNIEQGNFPKWKMFIQIMTEEQAKTYRFHPFDLTKVWSKKDFPLIEVGEFELNRNPENYFQDVEQAAFNPTNIVPGIGFSPDKMLQGRLFSYGDAQRYRLGVNHFQIPVNKPTCPYHAFHRDGAMRVDGNYGGTKHYEPNSYGEWQEQPEHKEPPLELSGDAFAHNFRDDDEDYFTQPGDLFRIIKADGKAEELFKNTAVNIGGAEKFIQIRHIRNCYKADPDYGKGVAYTLGLDMDEVMNFDMTPYDRYAPKRTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X177</accession>
    <name>C6X177_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone with DnaK heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01747"/>
    <dbReference type="EnsemblBacteria" id="ACU08190">
        <property type="protein sequence ID" value="ACU08190"/>
        <property type="gene ID" value="FIC_01747"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01747"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1774657_0_0_10"/>
    <dbReference type="OMA" id="YHFLVSI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025309">
        <property type="entry name" value="KTSC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13619">
        <property type="entry name" value="KTSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="166" mass="19482" checksum="5527D01C43DBD404" modified="2009-09-22" version="1">MLQIYTEGIIPNQIKIIAMKRIGEHRKLLGVDKSATLKDLKTIYRNTMKEAHPDKFVNDEEAKLEAEERSKSVIEAYHFLVSINPETQEKYKEEYTETTSKSNIQDFEFEKQILKIQHLNGKMFEYIGVPRNTYIKMVNADSPSRFARRHIYGNFIYRKSGEAMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A5</accession>
    <name>C6X1A5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerol transferase</fullName>
            <ecNumber evidence="3">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.6.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01775"/>
    <dbReference type="EnsemblBacteria" id="ACU08218">
        <property type="protein sequence ID" value="ACU08218"/>
        <property type="gene ID" value="FIC_01775"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01775"/>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828332_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="335" mass="38645" checksum="E5F00A3DE4662FD3" modified="2009-09-22" version="1">MDKTPAHFNLYNVLKKNGFSTGFFYGGDAKFDKMDRFLTYSGVDRIVDQGSFGALYRKLPAINGDSWGYDDQSVFAKMLEVQKPDQKPYFNMLFTLSTHSPFLINRKDYYENLFKKTMSSGRLSKEQKEWSAKHKKQLTAVLNADDALRGFFTRYKQRPDFANTIFIITGDHSMPEILLQSKADRFHVPLLIYSPLLKESRRFSTTVSHFDVAPTLLAYYRNNYGLHTPKTVAWTTDGLKGAGDKLERGIPIMKSKDQLHNFIFGNYHLEENQLFQLKNLEEDPINDEEERSRVKAHFSNFKAMNAHFSSVKKLLPDSVTINFFKSAKKPAPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D6</accession>
    <name>C6X1D6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">mRNA 3'-end processing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01806"/>
    <dbReference type="EnsemblBacteria" id="ACU08249">
        <property type="protein sequence ID" value="ACU08249"/>
        <property type="gene ID" value="FIC_01806"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01806"/>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050517_1_0_10"/>
    <dbReference type="OMA" id="FYIDPWR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026360">
        <property type="entry name" value="Xnuc_lig_assoc"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04122">
        <property type="entry name" value="Xnuc_lig_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="353" mass="39703" checksum="E7F8453D43CD23F0" modified="2009-09-22" version="1">MLNPSKLFRILKLIQFTNKGIYCIPGKFYIDPWRPVDLAVISHGHGDHAKCGMKKYLCQDFTKPILRHRIGPDIEVQSLPYGEEIVINGVKVSFHPAGHIVGSAQVKMEYKGYVTVFSGDYKVQDDGLSTPFELVRCNEFITESTFGLPIYNWLQPEQYSEQMQTWHNSNREIGKTSVFIGYSLGKAQRIMKALEGCGKIFVHSSVARINEAIEASGIKLPEYECVNFQEDLKKTNNEIVIVPPALLDSNVIRKIPNRATGLCSGWMQVRGSRRWRSADAGFAISDHADWGGLLATVKATGAEKVHVTHGQTAVFSKYLNEIGIEAYEVKTNYGDEEEEEKVLLQETTEPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G8</accession>
    <name>C6X1G8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC/Lrp family transcriptional regulator protei n</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01838"/>
    <dbReference type="EnsemblBacteria" id="ACU08281">
        <property type="protein sequence ID" value="ACU08281"/>
        <property type="gene ID" value="FIC_01838"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01838"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_10"/>
    <dbReference type="OMA" id="GPSKLHM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="19144" checksum="7532800B9EE86751" modified="2009-09-22" version="1">MKNDKNIEQLYMKSAMNSSYHLDSVDKEIIYMLMDNAKTSLAHISKNVGISTTAVHQRIKKLEQAGVIENSISFLNPRKIGYKVVSYIGVFLEQPSHYHDAVKALKEVNEVVEAHYTTGNYTIFLKVLCRDNDHLMEILNKLQKLKGVTRTETFISLEQSINRQLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L0</accession>
    <name>C6X1L0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor, plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806608.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01880"/>
    <dbReference type="EnsemblBacteria" id="ACU08323">
        <property type="protein sequence ID" value="ACU08323"/>
        <property type="gene ID" value="FIC_01880"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01880"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OMA" id="FSDWAVE"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973480" evidence="5">
        <location>
            <begin position="32"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="57"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="328"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110690" checksum="6FDF6549D00D67F5" modified="2009-09-22" version="1">MLRTKNNYMKRNTITVTCIAAVFFLGISAHAQSVQDTVLKENKIEEVVMIGYGSVRKSDLTGSVATVSGDALKQIPVSNVAEALTGKVAGVQIISTEGAPDAEISLRVRGGGSITQDSSPLIIVDGFPVGSMSEVTPSDIETITVLKDASSTAIYGSRGAYGVVLITTKGAKSGKVTGAFNSFTGYKWLAKKINVLTPYDYAKWQFENALLLNDVPSYNNYFLPFNQIDQYRSYEALDWQDRIYGNTGVVHSNDFGVRGGNEKTSFNINLANFKDDGIMLGSGYNRDNITVNLKNKPKDNVDLSVTFRYSNTDIKGGGANEQREFSNTDARLRHSVGYSPIDIPALTTDDTDEAEAGYLVNPYVAVRDNDRRQNRKNYTVQGGLGWTIIKNLKFQSNVGMEFSRLQDYRYYGRSTYYAKNNAPSTLQGLPAMAFTNTEREGFRIANTLNYDFKSILSDNHSLRLMVGQEYNNLKSNVLSTLNFGFPRLFSFDDTVNLTSEAQDFSISNEYAPDDRLLSFFGRLNYDFLNKYLLTATLRADGSSKFAANNKWAYFPSVAVGWKVNEENFLNDVSWIRLLKLRASYGEAGNNGIPTGVSVQTFQSTQTTWINDVSSYWAAAKILANPDLQWETTVSQNAGLDYELFNGRISGTVEVYKNITKDLLIPFPTPGTGYDGQWRNMGETQNKGVETSLNIEAIKKEDYSLSLGFNVSFNKNNINELGSGMEELLQSSNFASAVGVDYLVRVGLPLGVMYGYQNDGRYEVADFDYTTGSPVLRTGIANASAIVGAVKPGSMKLRDINGDGIVNADDRTIIGNATPKHTGGFTLNATAKNFDFSAGFNWSVGNDVYNANKIEFSTTTISSPDGQFRNLSTEMADGIRWTNMDSAGNLVTDPDQLAALNAGTTMWSPYMPRYVFSDWAVEDGSFLRLNTLTLGYSLPDSFVRSIKLTKFRLYASAYNVFVITNYSGMDPEVSTRRQTPMTPGVDYSGFPRSRQVVFGANLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L2</accession>
    <name>C6X1L2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806610.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01882"/>
    <dbReference type="EnsemblBacteria" id="ACU08325">
        <property type="protein sequence ID" value="ACU08325"/>
        <property type="gene ID" value="FIC_01882"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01882"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_10"/>
    <dbReference type="OMA" id="SHCVWSD"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="340" mass="37986" checksum="48E0601931EEF99E" modified="2009-09-22" version="1">MNNKVTIYDIAKELNITAATVSRALNGNPNISEKTRDKVISMASSMNYKQNKLALALKSGKSNYIGVIVPRINTNFFGSVIRGLEEELNAKGYNIIICQSHNDEEQESKNIETLIDSHVDAIFISSSSKNTTSLEKILKGNIPLIFFDRKKIMDNVSSVTIDDFAGGYMATKHLIDTGCRRIAHIASGPLEIEIFRERHRGYQQALADHNIDYRKEYCLQTNSSIEDGKKAVEILFSLDEKPDAIFSASDFVALGAIQELQARNIKVPDDVSVIGFANEPFTDFLELSISTVDQFPIEMGRSAAKVYLSQETENKEEGKVQKKVVLEPKLILRKSTRSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1X5</accession>
    <name>C6X1X5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ordered locus">FIC_01996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806723.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01996"/>
    <dbReference type="EnsemblBacteria" id="ACU08438">
        <property type="protein sequence ID" value="ACU08438"/>
        <property type="gene ID" value="FIC_01996"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01996"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_10"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="22918" checksum="22B0DEB5B60D872A" modified="2009-09-22" version="1">MARYIGPKTKIARKFGAAIYGDDKNFEKRKNQPPGQHGVNKRRGSKKSEYAVQLMEKQKAKYTYGILERQFANLYEKAQRAKGVTGEVLLQLCESRLDNVVYRLGFGKTRAGARQLVSHRHVTVNGELVNIPSYLLKAGDVIAIREKSKSLEVIADSLAGKANYEWLQFNDEKKEGTFVSAPERIQIPEDIKEQLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z0</accession>
    <name>C6X1Z0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ordered locus">FIC_02011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806737.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02011"/>
    <dbReference type="EnsemblBacteria" id="ACU08453">
        <property type="protein sequence ID" value="ACU08453"/>
        <property type="gene ID" value="FIC_02011"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02011"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_10"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="122" mass="13378" checksum="5B14706DD5B1DF48" modified="2009-09-22" version="1">MLQTESRLKVADNTGAKEVLVIRVLGGTRRRYASVGDKIVVTIKDSTPQGSAKKGTVTKAVVVRTKKAVRRKDGSYIKFDDNACVLLNATGEMRGTRVFGPVARELRDKEFMKVISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z4</accession>
    <name>C6X1Z4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="13" type="ordered locus">FIC_02015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806741.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02015"/>
    <dbReference type="EnsemblBacteria" id="ACU08457">
        <property type="protein sequence ID" value="ACU08457"/>
        <property type="gene ID" value="FIC_02015"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02015"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_10"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="251" mass="28274" checksum="DAD2A6127BAAD207" modified="2009-09-22" version="1">MGQKTNPIGNRLGIIRGWDSNWFGGKNYGDRIAEDYKIRRYLEARLSKGGISRIYIERTLKLVTVTITTARPGLIIGKGGQEVDKLKEELKKITDKDIQINIFEIKRPELDAVLVADSIAKQIENRISYRRAVKMSIQSTMRMGAEGIKVQISGRLNGAEMARSESFKDGRIPLSTFRADIDYHIGEALTQYGKLGVKVWIMKGEVYGKRDLSPLVGQQKKGAPAGRGDRNDRNDRGDRGGDRRPRRNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X201</accession>
    <name>C6X201_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02022"/>
    <dbReference type="EnsemblBacteria" id="ACU08464">
        <property type="protein sequence ID" value="ACU08464"/>
        <property type="gene ID" value="FIC_02022"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02022"/>
    <dbReference type="eggNOG" id="ENOG502ZXDD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066214_0_1_10"/>
    <dbReference type="OMA" id="QTHRFIY"/>
    <dbReference type="OrthoDB" id="1509557at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005901">
        <property type="entry name" value="GLPGLI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09697">
        <property type="entry name" value="Porph_ging"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01200">
        <property type="entry name" value="GLPGLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="285" mass="33181" checksum="AC53D4CFBDA05658" modified="2009-09-22" version="1">MDKLIAMKNLLLLILLLSSLCTAQTHRFIYGFQFKSDSLAKEFRTENMVLDVNPDNVKFYPYMYAENDSLNKVRDFKNIIWDDSVPALSRKRDSNENVSFLLTSDFFSIKTVDPISWKLTEETKKSADYTLQKATTQFGGRNWTAWFSKEVPISEGPYKFRGLPGLIFELYDDKDNFKFALIKSQQFKDTYDTSLFLESFAGKKPIAITEKVWLAKQLENYNDPLREMKQAYKNNTDPSARFMYAGKQVTGLDQFKPLTEDAQARIRRENNPIEISKAIRFPQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X252</accession>
    <name>C6X252_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806799.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02078"/>
    <dbReference type="EnsemblBacteria" id="ACU08515">
        <property type="protein sequence ID" value="ACU08515"/>
        <property type="gene ID" value="FIC_02078"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02078"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_1_3_10"/>
    <dbReference type="OMA" id="YVPKIGL"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="36"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="295" mass="33137" checksum="7EA8F56C7344C6C0" modified="2009-09-22" version="1">MIIAAIDIGSNAARLLINEVKEPKKGKPEFTKLNFLRIPLRLGIDVFAHGEIGPEREQMVIDCMRVFSGLMKVYKVEHYRACATSAMRDARNGAAIISQVKAESGIDIEIISGDQEAALVFENHIAEGLDKDFAYLYIDVGGGSTELTFYENGAMQHEHSFNIGTIRLLNNLVTDNHWKEMKEEIRKNINSKKPVVAIGSGGNINKIFSMSKTKEGKSMSIVLLRKYYKELNSLTLAERMTKFGLREDRADVLVPALEIFNKVMTWSEIEKIFVPKISVADGLIHNIYEGLRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X275</accession>
    <name>C6X275_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806822.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08538">
        <property type="protein sequence ID" value="ACU08538"/>
        <property type="gene ID" value="FIC_02101"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02101"/>
    <dbReference type="eggNOG" id="ENOG5032XAP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081809_0_0_10"/>
    <dbReference type="OrthoDB" id="1038985at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="34382" checksum="7BDB706EE1A8626B" modified="2009-09-22" version="1">MNTKETKINYFSLIKRLYKSSKQEENEEMYFQEVFENLRKIKSLSKFNRTYDLKGNKFCLLDNLTLNDKTCYGYFKSARNEFRPKLIDRKTLVERNNPKFKSEGDIEKTHFLIKQDSTGEVILFLEHNHFGITINNFINYVQTFSKSLDAKNNVPTRYKIVFAIIAKHNFLTELEHMQRAKLAEVYIDKQLLGNDALNFSEKIVQIKQDVKLTVKADLKSDLTKFGVDIFNKFNGKTDVGINRIRIYGVDENGNSSFVDTSFMGKVDFVNANLNEDTGETISGDFLNDLVNISENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X282</accession>
    <name>C6X282_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806829.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02108"/>
    <dbReference type="EnsemblBacteria" id="ACU08545">
        <property type="protein sequence ID" value="ACU08545"/>
        <property type="gene ID" value="FIC_02108"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02108"/>
    <dbReference type="eggNOG" id="COG4314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080177_0_0_10"/>
    <dbReference type="OMA" id="QFTTHSY"/>
    <dbReference type="OrthoDB" id="939371at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="197" mass="22359" checksum="9C319825072A20BD" modified="2009-09-22" version="1">MKNNSLHKITRILLAVCGVALVVSIFVPMWSIYLTAPQYPEGLSMFLWSNKITGEYEIINGLNHYIGMKTIHAEDFWEFKVLPYALAFFALLCLATAFLNKKMWLYVTAVLFMMFGVAFMVDFWLWEYDYGHNLDPNAAIVVPGMSYQPPLIGFKQLLNFGAYSYPNIGGGIMFGVALILAILAFIEYRKPVSTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2I3</accession>
    <name>C6X2I3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806930.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02211"/>
    <dbReference type="EnsemblBacteria" id="ACU08646">
        <property type="protein sequence ID" value="ACU08646"/>
        <property type="gene ID" value="FIC_02211"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02211"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_10_1_10"/>
    <dbReference type="OMA" id="PQYGEAY"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973375" evidence="2">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="203" mass="23117" checksum="522550AD81CAC2F5" modified="2009-09-22" version="1">MKQILSLIIVLLFYVSSPSQARAKYLELGKTEMANQNFDEAIKLFSKSIKKNQKKSESYFARGLCYNLLQDYDKSISDFTEAEKLGNRDAKLYTLRAFAYSVNEKNDLALQDLDKAIAIDPEAYIGNYYNRAMLQLSFNKYDLALQDLNDYLARAEDPNGYHERGKTLMSKGDLKAACEDFRKSAALGNKDEKLLKAIEAICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K0</accession>
    <name>C6X2K0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806947.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02228"/>
    <dbReference type="EnsemblBacteria" id="ACU08663">
        <property type="protein sequence ID" value="ACU08663"/>
        <property type="gene ID" value="FIC_02228"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02228"/>
    <dbReference type="eggNOG" id="ENOG5032VD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1560543_0_0_10"/>
    <dbReference type="OMA" id="YEDWATI"/>
    <dbReference type="OrthoDB" id="1497096at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025348">
        <property type="entry name" value="DUF4252"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14060">
        <property type="entry name" value="DUF4252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970565" evidence="1">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="174" mass="19939" checksum="277723A1874AFBC7" modified="2009-09-22" version="1">MKKFSSIIIPVLILMSMQSCMVSHKPKMGFFDKAQYDYKDAKFTSINVPMFLAKPLVKNALKEDGESEELINLIRKISDIKVMTIENGNKTMLAHYAKYLTQNNFEEWMSVKKESETVKFQAKQNGDVIRKLLITVHSGNELVFVDVSGKFTADDISRIINYSEKNDVKKMVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L1</accession>
    <name>C6X2L1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NG,NG-dimethylarginine dimethylaminohydrolase 1</fullName>
            <ecNumber evidence="1">3.5.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806958.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02241"/>
    <dbReference type="EnsemblBacteria" id="ACU08674">
        <property type="protein sequence ID" value="ACU08674"/>
        <property type="gene ID" value="FIC_02241"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02241"/>
    <dbReference type="eggNOG" id="COG1834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057463_2_0_10"/>
    <dbReference type="OMA" id="HLDCCFQ"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016403">
        <property type="term" value="F:dimethylargininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="304" mass="35324" checksum="AE19EECD8CB45862" modified="2009-09-22" version="1">MKLNIKNETSRLKSVVLGLPVSMGPPHALEHSYDAKSYHSIQNGIYPGEECIIQEMTAFEKVLLKHDVEVFRPTLIENYNQVFARDVAFVIDDKMIISNIIQDRYDEQDAYRKIFARVGWKKIINLPDTAHIEGGDVIVWNDFLFIGTCFSEDYRSYKTARTNEYAIEILKEYFPKKRIIDLELRKNDFDAFAGILHLDCSFNPVGTDKCIIYKDGFVDESDYRLLLDIFGEENCFHVTKQEMFEMNPNIFSISPEIVVSDKSFTRMNNHLRNEWGMTVEEIPYREISKMGGLLRCSTLPLARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L9</accession>
    <name>C6X2L9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02249"/>
    <dbReference type="EnsemblBacteria" id="ACU08682">
        <property type="protein sequence ID" value="ACU08682"/>
        <property type="gene ID" value="FIC_02249"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02249"/>
    <dbReference type="HOGENOM" id="CLU_3365108_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="4134" checksum="8ACEB5C167A2D75C" modified="2009-09-22" version="1">MQHSTWLKKPTLHSSPEKTKNRKNAKKCLISQKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N2</accession>
    <name>C6X2N2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806979.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02262"/>
    <dbReference type="EnsemblBacteria" id="ACU08695">
        <property type="protein sequence ID" value="ACU08695"/>
        <property type="gene ID" value="FIC_02262"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02262"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_10"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="284" mass="31525" checksum="991EF04BB14C9A60" modified="2009-09-22" version="1">MKTYAGIPEENATLENSKVMLVTVPYDGTSTWGKGADKGPELFLDASENMELFDIETRTEPYLEGVYLAGEISENSTPEAMTEAVYQKTKELLNHDGKLFTLFGGEHSVSIGSIRAVGEKYENLTVLQLDAHTDLRPDFHGSTSNHACAVYEASKKHNLVQVGIRSMDAEEMEHVNQEQCFWAHGIATNPNWIDDVLAKVSGNVYITIDLDAFDPSIAPSTGTPEPGGLQWYPTLELLKKVFEKCNVVAFDIVELMDSPMPKPSAFLAAKLYYKMLAYYHLTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N4</accession>
    <name>C6X2N4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806981.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02264"/>
    <dbReference type="EnsemblBacteria" id="ACU08697">
        <property type="protein sequence ID" value="ACU08697"/>
        <property type="gene ID" value="FIC_02264"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02264"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_2_10"/>
    <dbReference type="OMA" id="YHGRRPM"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="25031" checksum="8054FEF22694DFCA" modified="2009-09-22" version="1">MPLKAILFDMDGVIVDTEPLHRKGYFQMFENLNISVSEELYTSFTGSSTQKVCTTLVEKFNLNSTHEELASIKRRYFKHYFDHDVDFDLLPGVKNLIENYYNNGLKLILASSAHMNTINWVFEKFGLEKYFSAKISGASLKESKPHPEIFQLAAKMAGEPKENCLVIEDSTNGILAAHAAGIFCVAYKSEHSLDQDYSKANLVISDFSEIEMGKIEKFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N6</accession>
    <name>C6X2N6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806983.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02266"/>
    <dbReference type="EnsemblBacteria" id="ACU08699">
        <property type="protein sequence ID" value="ACU08699"/>
        <property type="gene ID" value="FIC_02266"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02266"/>
    <dbReference type="eggNOG" id="COG1564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_1_1_10"/>
    <dbReference type="OMA" id="TGKREDH"/>
    <dbReference type="OrthoDB" id="1628990at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="6">
        <location>
            <begin position="129"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="23449" checksum="42D25370D7680219" modified="2009-09-22" version="1">MDKTLLFINGLPPEQLPDTDAYSLIACSDGAFHYLKDKNFATEKLDFIAGDFDSHSGADDGIYQEKFIYTPDQEKTDFHKCLEIIEQRGFKEVDVYGGSGGEMDHFLGNLHTSFLFKDSIKITFFDEFSKYFLAPKKLVLERVEGLLVSLIPFPLASDVVTKGLNWELSGEKLAITSRIGSRNFAAADTVEISFGEGDLVVFIGRETYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N8</accession>
    <name>C6X2N8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02268"/>
    <dbReference type="EnsemblBacteria" id="ACU08701">
        <property type="protein sequence ID" value="ACU08701"/>
        <property type="gene ID" value="FIC_02268"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02268"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_3_10"/>
    <dbReference type="OMA" id="RIASNNC"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="106"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="19596" checksum="53B27E320D3836C1" modified="2009-09-22" version="1">MQAMPETTHNFDQLYKEFSPRIYKLCLSYSGDRLFADDLHQETWIAVWNSLPKFRGESKIGTWIYRIAINTCLVGVKKHKNKADNSEAILSGLIHEETLDNSKEINRLYESISKLKENERIIITLVLEEKPYEEIAEITGITENNLRVKIHRIKKELHEIYLNHGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P8</accession>
    <name>C6X2P8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein of hypothetical function DUF423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0382 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806995.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02278"/>
    <dbReference type="EnsemblBacteria" id="ACU08711">
        <property type="protein sequence ID" value="ACU08711"/>
        <property type="gene ID" value="FIC_02278"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02278"/>
    <dbReference type="eggNOG" id="COG2363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096548_3_1_10"/>
    <dbReference type="OMA" id="QMYHAIV"/>
    <dbReference type="OrthoDB" id="1985942at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="PTHR43461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="128" mass="14358" checksum="F1DE5D44C3A27C3F" modified="2009-09-22" version="1">MKTFTLVVGAVYGLLSVILGAFGAHAFRKILSPEKLESFETGVRYQMYAAFFLLIVGYILKFETTSEKWISILMIAGTFIFSVSIYLLAFNGISGMNFKFLGPITPIGGLLMIISWLMLIFYFVKDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R0</accession>
    <name>C6X2R0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acpP</name>
        <name evidence="11" type="ordered locus">FIC_02290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807007.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02290"/>
    <dbReference type="EnsemblBacteria" id="ACU08723">
        <property type="protein sequence ID" value="ACU08723"/>
        <property type="gene ID" value="FIC_02290"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02290"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_10"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="79" mass="8786" checksum="3476B189FE0A974C" modified="2009-09-22" version="1">MSDIASRVKAIIADKLDVEETEVTPEASFTNDLGADSLDTVELIMEFEKEFNIQIPDDQAEKITTVGHAITYIEEVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W7</accession>
    <name>C6X2W7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02347"/>
    <dbReference type="EnsemblBacteria" id="ACU08780">
        <property type="protein sequence ID" value="ACU08780"/>
        <property type="gene ID" value="FIC_02347"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02347"/>
    <dbReference type="eggNOG" id="ENOG5031MUN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131427_0_0_10"/>
    <dbReference type="OMA" id="KTWTANA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="174" mass="19289" checksum="5AB962506D210665" modified="2009-09-22" version="1">MLIQSHQRLKIKTRSFSGTRFGKSSALTVKYIIMKSIALNSKASILRKTAKFAGLLMLIFSVFALSSCSRDDDPSDNDFFAGTYRGTLTYNDGTTNITKENGSVFVTKIGSATKYNFRFSDGIPDINGIEFQKEGDNTMVMVGSTATSYIRIDNKDLKILYSNNGKTWTANANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W8</accession>
    <name>C6X2W8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02348"/>
    <dbReference type="EnsemblBacteria" id="ACU08781">
        <property type="protein sequence ID" value="ACU08781"/>
        <property type="gene ID" value="FIC_02348"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02348"/>
    <dbReference type="HOGENOM" id="CLU_3061773_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="53" mass="6239" checksum="A2E0F47E110948F5" modified="2009-09-22" version="1">MEIILPSTYALEFSVESLRQPLIIKTKIRNSRLVLRRNFIGEFGLKIQKNCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y6</accession>
    <name>C6X2Y6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ordered locus">FIC_02366</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807083.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02366"/>
    <dbReference type="EnsemblBacteria" id="ACU08799">
        <property type="protein sequence ID" value="ACU08799"/>
        <property type="gene ID" value="FIC_02366"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02366"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_10"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU08799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="330" mass="36132" checksum="6124D9E06A5453A2" modified="2009-09-22" version="1">MKIAVVGATGMVGQVMLKVLEERNFPVTELIPVASEKSVGKKISFKGQEYDIVSMQTAIEMKPEIALFSAGGTTSLEFAPQFAAAGTTVIDNSSAFRMKPENKLVVPEINADQLTAADKIIANPNCSTIQLVMVLHPLNLKYNLKRVVVSTYQSVTGTGKNAVDQLNAEIAGNSGAEKVYPYEIFKNALPQCDVFAEDDYTKEEIKLMTEPKKILGDDTFNLTATAVRVPVQGGHSESVNIEFENEFDLDELRKLLSETPGVTVMDDVANSIYPMPLYSEGKDEVLVGRIRKDLSQPNTLNMWIVADNLRKGAATNAVQIAEYLVEHKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y7</accession>
    <name>C6X2Y7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807084.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02367"/>
    <dbReference type="EnsemblBacteria" id="ACU08800">
        <property type="protein sequence ID" value="ACU08800"/>
        <property type="gene ID" value="FIC_02367"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02367"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_0_10"/>
    <dbReference type="OMA" id="YGHQRIE"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="229"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="333" mass="37722" checksum="37F3D5BE0A2F72D7" modified="2009-09-22" version="1">MSETATSTRTNFAFQRRVAIVGIVLFVAKLIAWHLTDSDAVFSDAMESIVNIVAGFLGLYSLYVASKPKDTDHPYGHGKAEFVTSGVEGALIIFAGVIIIVQAADSLLHGNVPKQLDWGMLIVAVTAGINYLMGYISYQKGIQENSLVLQSSGKHLQSDTFTTVGVVVSMILVYFTDLYWIDALVAMLFGGYIMFVGYKIIRKSLSGIMDEADPRMLVKLSKFLNEKRQREWVDIHNVRIQQHGSVLHIDAHLTLPWYFELRTAHAEMEEVYKLIGDNTDREVEFNFHLDDCKPFSCEICELWECKVRQNAFKKRIEWNEKTISQVQKHDVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X300</accession>
    <name>C6X300_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02380"/>
    <dbReference type="EnsemblBacteria" id="ACU08813">
        <property type="protein sequence ID" value="ACU08813"/>
        <property type="gene ID" value="FIC_02380"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02380"/>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_10"/>
    <dbReference type="OMA" id="KWGSFDK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="105"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="208" mass="23415" checksum="5B5A9CEDD587C002" modified="2009-09-22" version="1">MGINRLNNKIMAFELPKLGYAYDALEPIIDAKTMEIHHTKHHQAYIDNLNKAIEGTELEGKSIEEICKTGVDKAAVRNNGGGHFNHSLFWDILTPGGSKEPVGNVKAALETYGGFDKFKTDFAEAAKTRFGSGWAWLCKTQDGSVAVCSTANQDNPLMPIVDVQETPILGLDVWEHAYYLNYQNRRPDYVSAFFEVINWDKVEERFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X362</accession>
    <name>C6X362_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807159.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02442"/>
    <dbReference type="EnsemblBacteria" id="ACU08875">
        <property type="protein sequence ID" value="ACU08875"/>
        <property type="gene ID" value="FIC_02442"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02442"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_4_0_10"/>
    <dbReference type="OMA" id="FMSHTRM"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="176" mass="20472" checksum="46B40E0DBA560A09" modified="2009-09-22" version="1">MSVYHYKFDVRWSDIDANKHLANSSYVAYCAQTRMAFMNTHHMGLKELSRWGIGPVILHERFSFFKEIYADQTVYVTAEVSGMSEDASIYQFVHKFYLPEGTHCATAEATGVWIDMMLRKSTTPPDDIVEVLNEFKSENTKVLTREDLRDLPFKPENVEAFHKQGTFAWRKNSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X374</accession>
    <name>C6X374_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807171.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02454"/>
    <dbReference type="EnsemblBacteria" id="ACU08887">
        <property type="protein sequence ID" value="ACU08887"/>
        <property type="gene ID" value="FIC_02454"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02454"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147162_7_1_10"/>
    <dbReference type="OMA" id="YTIHYIV"/>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="91" mass="11018" checksum="697F796B9137D19C" modified="2009-09-22" version="1">MKYFVTLSDLAEIDLEETNSYYSRIIDEVLQRFWSDLNQTMEKLAANPLLFQKRYQNTRIVFLENFPFVVHFIIVGEELEVLRILHTKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X388</accession>
    <name>C6X388_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">murD</name>
        <name evidence="17" type="ordered locus">FIC_02468</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02468"/>
    <dbReference type="EnsemblBacteria" id="ACU08901">
        <property type="protein sequence ID" value="ACU08901"/>
        <property type="gene ID" value="FIC_02468"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02468"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_10"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="116"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="314"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="118"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU08901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="457" mass="51142" checksum="7A54CDF74FD45EBD" modified="2009-09-22" version="1">MFLNLKSKKDMKIVVLGGGESGFGAAYLAKKKGLDVFLSDKGLIREDYKKLLTAAEIDFEEGKHDEERILAADWIIKSPGIPKKADIIFKINQKDIRLSSEIEFASEFTNAKIIAITGSNGKTTTTSLIYHILKNDGLKVGLGGNIGKSFAKQVADESFDYYVLEVSSFQLDDIQNFRPHISLLLNLSQDHLDQYNYNYEEYALAKFRIAENQENDNFFIYNKDDEMSQNLLEKLEVKAKMIPFSLKEKLKEGGFFTGDKMVVKLQDEFSMDIAELALVGNHNVANSLAASIAGKILKISNESIRNSLMTFQAVQHRLEQVAETGGVRFINDSKATNVNATYYALESMKQPTVWIVGGIDKGNDYTEIEDLVKRKVKAIVCLGLDNQKIVDFFKSKKDLIYSTSSMAEAVNISKSLAAKGDAVLLSPCCASFDLFENYEDRGNQFKKEVFKTETVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A3</accession>
    <name>C6X3A3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807200.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02483"/>
    <dbReference type="EnsemblBacteria" id="ACU08916">
        <property type="protein sequence ID" value="ACU08916"/>
        <property type="gene ID" value="FIC_02483"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02483"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_4_1_10"/>
    <dbReference type="OMA" id="MWYWKKN"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="47"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="243" mass="27362" checksum="2ACE3AF69E3C9A53" modified="2009-09-22" version="1">MFNNIPPLTRNLIIINVIVFILVWLMQNDQITMYLAAFYPFSPFFHSWQIITHMFMHGSFMHILFNMMTLYSFGPVLEQVLGEKKYLLLYFVSGLGAFFLFNLWNFVEIEQIKASLQSFGFDLDGYLRGARVMFSGNSAQIAEQQGLVAAMQDIITIPMVGASGAIFGVIAAFATLYPDAKIMLMFIPVPVKVKYLMPVVIIVSIYLGVSGNVGGIAHLAHVGGALVGFILARIWRKHLYRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A8</accession>
    <name>C6X3A8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02488"/>
    <dbReference type="EnsemblBacteria" id="ACU08921">
        <property type="protein sequence ID" value="ACU08921"/>
        <property type="gene ID" value="FIC_02488"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02488"/>
    <dbReference type="eggNOG" id="ENOG5032X1Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128373_0_0_10"/>
    <dbReference type="OMA" id="FIHAMIY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="257" mass="30142" checksum="2A8FB46DBC4DD39D" modified="2009-09-22" version="1">MRELITHALSLKAYFCAMQNSLQPQTGIAPVMKKAFFYWNKTLLYQLVFSILYFSLFFIGYFYLLQYFGLWDEFMKHKDLVSTDLPAFNQKMEEIARLPQARNFGLAFFFLTALINPLNVGLYTIYRKIDLNEPVVLNDLFAGYQGATFFRFVGFYLFWMIIFTYTNALFLLGIVWFLVTLFCVPLMYFMDVQIFQGIALTFKVLRRNFGVVCITVIGALLFAFSGFLLCGIGILFTFPFIHAMIYTLYQQFYTEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B3</accession>
    <name>C6X3B3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PQQ-dependent oxidoreductase, gdhB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807210.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08926">
        <property type="protein sequence ID" value="ACU08926"/>
        <property type="gene ID" value="FIC_02493"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02493"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_1_1_10"/>
    <dbReference type="OMA" id="IWSKGHR"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="79"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="409" mass="44549" checksum="C15EA32FA792EB21" modified="2009-09-22" version="1">MKVFLAKILPVCAAVVLTACSGTPKNNAQAQVLKNGTLANPETASKNSPEYQPAFEGQTRVNGLQTSTAYQVDVINSGLNKPWGITDLPDGRLLISSKSGYLNIVSADGKNTVKVEGLPKVDDKGQGGLLDIALDPDFNTNRMIFWTYSEPVAGGNHTAVAKGKLSADDKKIENPTVIFRATPTYDGDKHFGSRLVFDKDGHLFVSTGERSDMEMRPYAQRQDAYLGKVLKITKDGKPAPGNPTISGWKPEIYATGIRNPQGLALDEKGQLWDGEMGPKGGDEVNLIQPGKNYGWGDVSYGTEYSGKKINNGATQKAGTEQPVYYWDPSISMSGMDFYKGNIAEWKNNLMLGCLSGQKIIRLVIENNKVVGEEWLLTAQNDRIRDVLSARDGNLYAISDSGKLHRISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E1</accession>
    <name>C6X3E1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807238.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02524"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08954">
        <property type="protein sequence ID" value="ACU08954"/>
        <property type="gene ID" value="FIC_02524"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02524"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_36_3_10"/>
    <dbReference type="OMA" id="SHEVQTD"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="181"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="365" mass="41517" checksum="8E492071F2A517B9" modified="2009-09-22" version="1">MKIVVSAFSNLYTDQRIEKVCDTLVRGGYDITLIGNDYGGTGVLARPYPVKIIKQRSKSLKSAYPEFNWKLFFELRKTADKNTILLANDLDALLPNVAISKLLNIPLVFDSHEIFTEMPAIQGRFTQKIWRLLEKQLVPGIKYMMTESLSYANWFNEKYGVKPVVVRNIPKKITDLPMIPDNNPKIMLYQGAINQSRGIPQAILATKYLDDIIFKIAGDGPKLNEYKALVQKEKLGGKVEFLGKLIPEELRKVTRTADVAVSLEENGGVSYLYSLPNKVADCIQARVPLVMINFPEMMRVYSEFKIGEIVENHDPQNIAQKIKSVLNNGRAYYQDELERAAAELCWENEEENILTLFEKVVAENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F4</accession>
    <name>C6X3F4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gll2474 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807251.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02537"/>
    <dbReference type="EnsemblBacteria" id="ACU08967">
        <property type="protein sequence ID" value="ACU08967"/>
        <property type="gene ID" value="FIC_02537"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02537"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032905_0_0_10"/>
    <dbReference type="OMA" id="SNGADYQ"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973420" evidence="1">
        <location>
            <begin position="23"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="41"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="565" mass="65412" checksum="62A3D12CF128028C" modified="2009-09-22" version="1">MKFKLLLILFSSHLIFAQQKHATPYETGNGNQTVTYEEMVKYYDDLDRNFESVTVQNFGKDDNGEPIKVVVFNASKNRKNPVLLINNGIHPGEPDGIDATMTLMRDLATGKIKAKNLTVAAVQSYNISGMLRRGKYSRANQNGPEEYGFRGNARNYDLNRDFIKNDSENAKAFQQIFHHFKPIYFIDNHVSNGADYQYLFTYISTNKERLGKTLGTYFNEKMQPEILQTIEKQGILNTPYVNIHGDSPDEGFPAFMDSPRYATGYTTLFNTLGTVAETHMLKPYSERVRATYEYMLSSINYVAKNASEIQKKMSESLAGYQPGKKYPIQWKSDKNKFKLIDFKGYEAGKKTSVVSGKPRLFYDRTRPFTRKVKFFNEYIATKEIRIPNFYVIPKSENKVIEYLKRNHIEMKEIGQDSTVSVELYRIADYKTVKNPYEGHYLHYDTKIKSEIKNKTFRKGDFLVSTKQSGVKYLLETLEPEATDSFFNWNFFDAILGQKEYFSDYVFEDTAAELLKNDQVLRTAFEFEKISNADFAKDGAAQLEWIYKHSDYYEGSVGLYPIYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H1</accession>
    <name>C6X3H1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein adenylyltransferase SelO</fullName>
            <ecNumber evidence="9">2.7.7.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">selO</name>
        <name evidence="10" type="ordered locus">FIC_02554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:58120"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15073"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:142516"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.n1" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807268.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02554"/>
    <dbReference type="EnsemblBacteria" id="ACU08984">
        <property type="protein sequence ID" value="ACU08984"/>
        <property type="gene ID" value="FIC_02554"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02554"/>
    <dbReference type="eggNOG" id="COG0397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_4_0_10"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="OrthoDB" id="130048at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="514" mass="58318" checksum="A45DAF4552979B09" modified="2009-09-22" version="1">MNLDKITSPYLYIFPGDTSGNTRQRQTPKVLFASTKIVGFANAELIHFNQKLSDEIGLGPIETNADRDFLNATALPENIKTYATAYAGHQFGNWAGQLGDGRAIFAGEITNAAGKKTELQWKGAGATPYSRHADGRAVLRSSVREYLMSEAMFHLGVPTTRALSLSLTGEQVERDMLYNGNPQDEKGAVVVRTAESFLRFGHFQLMAAQDEIETLRQLADFTVSNYYPTIDPNDPQKYAELFRQIASRTADMIVEWYRVGFVHGVMNTDNMSALGLTIDYGPFSFLDEYSLNFTPNTTDLPGRRYAFGNQAKIAQWNLWQLASALFPLVNDVEILQNILNGFSDDFWKKHDKMMASKFGFDQLIEGDDSFFTAWQKLMEDLKIDYTLFFSRLEMTAGSDDLKTTFGDVFYSPVSDDSFKLFENFIETYRTRLTKNTITPEDSLQLMRKTNPRFVLRNYILFERIAELEQGKRDLFNKILTALESPYEELFPEFSKKRPAIYDDQSGSSTLSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H8</accession>
    <name>C6X3H8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein containing DUF336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807275.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02561"/>
    <dbReference type="EnsemblBacteria" id="ACU08991">
        <property type="protein sequence ID" value="ACU08991"/>
        <property type="gene ID" value="FIC_02561"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02561"/>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103773_2_1_10"/>
    <dbReference type="OMA" id="NNWAVTI"/>
    <dbReference type="OrthoDB" id="1551899at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="133" mass="13632" checksum="608FF7FA5C90771C" modified="2009-09-22" version="1">MNITLENAEKAVAAAKAKATEMGVLMNIAIVDSGANLIAFAHMDGAWLGSIDIAQKKARTARYFNMDSGEIGKLSQPGGSLYQIEHSNGGLITFPGGVCIKDADGEIIGAIGVSGDSVDNDHKVAKAGADALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J6</accession>
    <name>C6X3J6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ordered locus">FIC_02579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02579"/>
    <dbReference type="EnsemblBacteria" id="ACU09009">
        <property type="protein sequence ID" value="ACU09009"/>
        <property type="gene ID" value="FIC_02579"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02579"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_3_10"/>
    <dbReference type="OMA" id="INYIFCD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU09009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="142" mass="16587" checksum="0D30DC5C331C4372" modified="2009-09-22" version="1">MAIGFKIMIHFFFEDIDEIAISPEIKPWLENLLISEGKKPGVLNYVFCSDEYLLKINREYLDHDYLTDIITFDYVKGKTVSGDIFVSLHRISENALLHDNSFDTELLRVTAHGLLHLCGYKDKTEVEISEMRSKEDFYINQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L2</accession>
    <name>C6X3L2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusD, outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782147.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00542"/>
    <dbReference type="EnsemblBacteria" id="ACU07000">
        <property type="protein sequence ID" value="ACU07000"/>
        <property type="gene ID" value="FIC_00542"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00542"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_2_10"/>
    <dbReference type="OMA" id="WPWKGGT"/>
    <dbReference type="OrthoDB" id="159721at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972273" evidence="5">
        <location>
            <begin position="25"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="102"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="374"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="520" mass="57650" checksum="B47E2CEE460E7AA8" modified="2009-09-22" version="1">MKNFRITRNTIAAALLGLTLTVSSCVDDLRQEPVTEITAASLYKDFGNYKNLLAKLYGGLAVGGQSGGDGNGDIAGIDGGFSIYTRLLYTMQVVTTDEAVIGWNDGSLHEFHKMIWTPANEFSNAMYYRLYTEIAYCNEFIKNTTDEKLGENGITGENLNEAKAMRAEAKFLRAQAYYHLLDLYGNVPFVDETTFGTVPKQIKRAELFTYVEDQLKESEAELKAPKANEYGRLDKAAAWSLMARLYLNAKVYNGTERYADVIANCEKVIGAGYTINPSYANLFLADNHVNNPENIFSVVYDGQRTQTNGGTTFLVHAAIGGTMNAADFGVNGGWGGLRTTKAFVNKFEASDKRGRFHTDGQTLEINDLGNFNDGYAFIKYKNLKSNGTPGIHDNWVETDLPLYRLADIYLMYAEATLRGGGGNTATAIGYVNALRTRANASTISTINLDFILDERARELSWELTRRTDLIRFGKFTSSAYLWPWKGNAKDGIAVAEYRNLFPIPTNDLVVNPNLVQNPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M9</accession>
    <name>C6X3M9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782164.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00559"/>
    <dbReference type="EnsemblBacteria" id="ACU07017">
        <property type="protein sequence ID" value="ACU07017"/>
        <property type="gene ID" value="FIC_00559"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00559"/>
    <dbReference type="eggNOG" id="ENOG5032XW7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129685_2_0_10"/>
    <dbReference type="OMA" id="LLCWKIR"/>
    <dbReference type="OrthoDB" id="1669657at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="148" mass="17491" checksum="CFAE01C18E35E8FA" modified="2009-09-22" version="1">MKRHEALVQLSRDHHFGLLLCWKLKEGIKKNIAVERMAAYIKLFFQHNLDPHFTEEEETVFLVLGNDHPFIADALTEHGILRGMAGQEFKTPQDVQAFRDLLEIHIRKEERQIFPEIERQATPKQLAELLALPHQELKEPIFEDEFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P2</accession>
    <name>C6X3P2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00572"/>
    <dbReference type="EnsemblBacteria" id="ACU07030">
        <property type="protein sequence ID" value="ACU07030"/>
        <property type="gene ID" value="FIC_00572"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00572"/>
    <dbReference type="eggNOG" id="COG3427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158631_0_0_10"/>
    <dbReference type="OMA" id="FNAMMAM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="134" mass="15294" checksum="ABA079F57B4BE7A0" modified="2009-09-22" version="1">MYKNIKMKLEGRKIVVNKSADQLVEMLKNPEDYKALMPDSLQNFEARDNGFKFSLKGMPEIALKIENVTNSEVVLKSASSSLDFELKGTMNPVSENQTEVQLLFEGKFNPFIKMMVEKPLQNFINSLSDNLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q7</accession>
    <name>C6X3Q7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782192.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00590"/>
    <dbReference type="EnsemblBacteria" id="ACU07045">
        <property type="protein sequence ID" value="ACU07045"/>
        <property type="gene ID" value="FIC_00590"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00590"/>
    <dbReference type="eggNOG" id="ENOG502ZWR1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130847_0_0_10"/>
    <dbReference type="OMA" id="FWSPQLH"/>
    <dbReference type="OrthoDB" id="1992899at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="175" mass="20259" checksum="62FDC1A00622BEC7" modified="2009-09-22" version="1">MKIEQTVLDSIRSRPRFKIFTKVSGEQYAAHLKKFLEENSDAFSGNINAETATIKVKTSEDNYWKPNLALRTETDPERNQTVIRGIFGPSSAVWTFFMFLYFILGILWMVFITIWFVEKQINSNDFPWALSASLITVFLLVLTYAASLFGQQKAKKEMQKLREFAEESIAKLEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T8</accession>
    <name>C6X3T8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00621"/>
    <dbReference type="EnsemblBacteria" id="ACU07076">
        <property type="protein sequence ID" value="ACU07076"/>
        <property type="gene ID" value="FIC_00621"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00621"/>
    <dbReference type="HOGENOM" id="CLU_857255_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970633" evidence="1">
        <location>
            <begin position="22"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="324" mass="38684" checksum="B4E208D887B50E41" modified="2009-09-22" version="1">MKRHRYILTLILVLTFGTVFAHQDFWMTKDFGNVKVRIKTGFEYEEINKVFIIGKLAEQFSKQLKYTDKIFLDFNHHYTGNCEPDYFISYDKGKIQNSWNGAQKEIDFLKEKSIVVRQVSRRFDAETTLKLLEYSIQNVEQIKSLQKEIDYNKNYCQWIINSIDTTQINTILLEPVSNQIKIALKSKIEKPEKEFKYGLSYFFKDNKNSIFSREYNKDDKTLLTLDNIYDIKKIGSSSMIIFDTDSSFYYVNQYQNVVSKRHHISNSYDYYRPYKVENIDGDKISINFSYYSKEEGRQLKSRTLLYLIEKDELIQDLDKLIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y8</accession>
    <name>C6X3Y8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782272.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00671"/>
    <dbReference type="EnsemblBacteria" id="ACU07126">
        <property type="protein sequence ID" value="ACU07126"/>
        <property type="gene ID" value="FIC_00671"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00671"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_1_3_10"/>
    <dbReference type="OMA" id="HATVFNK"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="148" mass="16908" checksum="8703286F2C7E6ED7" modified="2009-09-22" version="1">MIRITKIFTFETAHVLYNYDGKCKNMHGHSYKLFVTVKGNPINDLDHPKNGMVVDFGDIKKIVKAEIIDVWDHAVLVNGASPQRDLGEDLEHKGHKVIFCNYQPTCENMLYEIAAKVKGRLPEGVSLAYLKLHETENSYGEWFAEDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X471</accession>
    <name>C6X471_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase I</fullName>
            <ecNumber evidence="3">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782355.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00754"/>
    <dbReference type="EnsemblBacteria" id="ACU07209">
        <property type="protein sequence ID" value="ACU07209"/>
        <property type="gene ID" value="FIC_00754"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00754"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_1_0_10"/>
    <dbReference type="OMA" id="KFHYGAR"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043739">
        <property type="entry name" value="DUF5684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18936">
        <property type="entry name" value="DUF5684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="132"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="400"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="550" mass="63747" checksum="2460DFB7B5831B59" modified="2009-09-22" version="1">MNYFIVYTLYVVVLSVLMGLSTWKLFKKMRYNPIFAFVPFYNYYLIQKATNHPKWWVAMAYLPIVGPIMMTVFHLFLMRHFGKTSFSQKLLTVILPFIYMAFVNYSKDADVETHDELYMTEEEKNAKKKESFVGSITFAVVFATIVHVFVTQPFGIPTGSMERTLLVGDFLFVNKWTYGFRMPMRPVAIPFLQGTIMDTGEKGNPKDDPKSYLEAVKLPYERILQFKKPQKNDIVVFNYPRDSVHTAIDRMDPYVKRCVAVAGDVIEMRGGRLFVNGKPETILGDQQMQHKFIAVTGSQLDIPALYKQYGFMPVQEMQTESGFVYDFQGLTDKTAKEIKELPQIIELKEHVWTKDSGAVSYKINAARDAFTKNIDTTQSIFPINKKWNQDWYGPLKIPKKGDVVTLNQETLPEYQWIISQYEHNTLENKNGKIFVNGRETTQYTIQQDYYMMIGDNRDASLDARFFGFVPEENIVGSPMFTWMSVEGLFADKGSSYQPDGKTIRWDRMFKATNTGEAHKTSYWWVAVLILVLFFGWDYIAGIFKKKPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X494</accession>
    <name>C6X494_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00779"/>
    <dbReference type="EnsemblBacteria" id="ACU07232">
        <property type="protein sequence ID" value="ACU07232"/>
        <property type="gene ID" value="FIC_00779"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00779"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4978">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806276_0_0_10"/>
    <dbReference type="OMA" id="PYEGQGS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="326" mass="37889" checksum="9E3456083C46A043" modified="2009-09-22" version="1">MSAAFVDGGKSFTVKKKISYPVDQVYPQFSNLQNFIYWNSFFSENKNLSYRFFSPYEGQGSSMRYHDRKNSDVYGDMFVRFANRNSTLRYQLYEGDSPKPYLIDLKFKPLNSATEVIWSIKTPEQPWWKPSNRLSDEDEVLENIDRSMNRLFAILGNKVQKDRQLQNIKFDSLMIEEAEGQLLLGVNVSAKNGKDALFRNIVLNHNKTLNFIKIDLAKKEDEYGEPVLITDADNYKDKEISYYYGIPVSSRVGISDNNFTFRTVNASRNYVVYYRGSYAGRIKAIQQILQQAKRDTLRTGDLQQTFLDEPSQENNTMIKLSVPVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B3</accession>
    <name>C6X4B3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbapenem antibiotics biosynthesis protein carD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782397.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00798"/>
    <dbReference type="EnsemblBacteria" id="ACU07251">
        <property type="protein sequence ID" value="ACU07251"/>
        <property type="gene ID" value="FIC_00798"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00798"/>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_3_0_10"/>
    <dbReference type="OMA" id="WMQDAAD"/>
    <dbReference type="OrthoDB" id="1746057at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="2">
        <location>
            <begin position="75"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="389" mass="45048" checksum="1E60B2C9B24AA4AF" modified="2009-09-22" version="1">MSIFNNTQIAFADKTDNQLRKGYWMFKLIEQPALTKIGTRILNFMVHNDVPFAGNLVKATLFEQFCGGETREESIKAVEQMYRRGVGSIFDYSIEGKEEESTFDAVYNEIKDIVKFSVGNPALPFIVFKPTAFGRIGIYEKVGKKEPLSDAENAEWARVVNRFDEVCKLCFENDKKVMVDAEESWMQDATDWLVEDMMEKYNTEKPIVWNTIQMYRTGRLEYMKQNLQRAQEKGYFIGYKIVRGAYMEKERERAVEMNYPDPIQPNKEASDKNYNDAIDFVMANVSRVSGFFGTHNEISSELVIEKMKANGLQNDDPRIYYGQLYGMSDNITYMLAEKKYNVAKYLPYGPVKDVVPYLTRRAEENTSVAGQTGRELSLISRELQRRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E5</accession>
    <name>C6X4E5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ordered locus">FIC_00830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782429.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00830"/>
    <dbReference type="EnsemblBacteria" id="ACU07283">
        <property type="protein sequence ID" value="ACU07283"/>
        <property type="gene ID" value="FIC_00830"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00830"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_10"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="285" mass="31665" checksum="D335FACBE557F4FE" modified="2009-09-22" version="1">MANLKEIRGRITSISSTMQITSAMKMVSAAKLKKATDAIVMLRPYSEKLQEIIENVSSTTDLEGISTFTEEREVKKVLYIVVTSNKGLAGAFNSSVIKELNNTISNTGYEVEILAVGKKVFDAVRRNRNVYDNQSAIFDGMNFQVVSNFMEHVMRDYSEGKFDKVFVIYNKFLNAATQQVQTEQVLPIAMAPKEGTANTDYLFEPNAAEILNVLIPKSIKTQVYKAILDSIASEHGARMTAMHKATDNAEALRNDLKIFYNKARQAAITNEILEIVSGAEALKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F6</accession>
    <name>C6X4F6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ordered locus">FIC_00841</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782440.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00841"/>
    <dbReference type="EnsemblBacteria" id="ACU07294">
        <property type="protein sequence ID" value="ACU07294"/>
        <property type="gene ID" value="FIC_00841"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00841"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_0_10"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="OrthoDB" id="1419568at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="51"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="211"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU07294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="285" mass="31559" checksum="24EBC17713AD846F" modified="2009-09-22" version="1">MNTLKIAIQKSGRLSEKSLELLRDCGIKFPDFKSKLKNTADNFPLEILFLRDDDIPKYVENGIVDIGIIGENEVKEQLRNVALVRRLGFAKCRLSLAIPREQIYNGNGFFNAKKIATSYPNIVRSYFEDRDVKPEIVEISGSVEIAPSIGLADAVADLVSSGSTLMHNGLTEVEEILRSEAVIIGNQALTEQTSSILDSFLFRIQAVMNSRENKYILLNAPDVAIPSITKLLPGMKSPTILPLAEAGWSSIHSVVKESAFWEIINELKKLGAEGILVIPIEKMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F7</accession>
    <name>C6X4F7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisD</name>
        <name evidence="11" type="ordered locus">FIC_00842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782441.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00842"/>
    <dbReference type="EnsemblBacteria" id="ACU07295">
        <property type="protein sequence ID" value="ACU07295"/>
        <property type="gene ID" value="FIC_00842"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00842"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_0_10"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="431" mass="46504" checksum="F59A391169905FEB" modified="2009-09-22" version="1">MNTIYKYPPREIWKNLISRNVLKQENLKAAVQEIFDQVAENGDCALKQLTLKYDRAELETFLVSESEINAAEALVSEKLKAAIATAKANIYTFHAAQKEDFGKIETMPGVSCWRVSRAIAKVGLYIPGGSAPLFSTVLMLAVPAQIAGCREVILCTPPRADGSIDPAVLFTAKLCGISKIYKVGGAQAIAAMNFGTESIPKVDKIFGPGNQYVTQAKMLATDYNIAVDLPAGPSEVLVIADRTAVPAFCAADLLAQAEHGTDSQVIFIAVDEEIFTQTLNEVSLQLEMLPRRDIAAEALENSRFILLDSVESALEFSNLYAPEHLILSVERAEDYLNDVASAGSVFLGNYTPESVGDYASGTNHTLPTNGFASSYSGVSLDSFVKKITVQQITVDGLQNIGQTVEIMAEAEGLSAHKNAVSIRLKMIKDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H9</accession>
    <name>C6X4H9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782463.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00864"/>
    <dbReference type="EnsemblBacteria" id="ACU07317">
        <property type="protein sequence ID" value="ACU07317"/>
        <property type="gene ID" value="FIC_00864"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00864"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045945_5_0_10"/>
    <dbReference type="OMA" id="AKGNRMF"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="112" mass="13001" checksum="5AC19FA3231A47E6" modified="2009-09-22" version="1">MKLNLPDKLYYSIGEVAKAFNVNASLIRYWEQEFPIIKPKKNKKGNRYFTPQDLKNLQIIYHLVKEKGYTLDGARIALTTNSKISETVSIINRLEFVKAELEKLKDSLVEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I6</accession>
    <name>C6X4I6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplS</name>
        <name evidence="5" type="ordered locus">FIC_00871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782470.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00871"/>
    <dbReference type="EnsemblBacteria" id="ACU07324">
        <property type="protein sequence ID" value="ACU07324"/>
        <property type="gene ID" value="FIC_00871"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00871"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_2_10"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="13758" checksum="4D33922EFEC260DD" modified="2009-09-22" version="1">MDLVKYVQDKYITKKEFPEFKAGDTITVYYEIKEGAKTRTQFFKGTVIQLRGTGLTKTFTIRKMSGDVGVERVFPINLPALQKIEVDRRGRVRRARIYYFRNLRGKRARIKDAAYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4J1</accession>
    <name>C6X4J1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782475.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00876"/>
    <dbReference type="EnsemblBacteria" id="ACU07329">
        <property type="protein sequence ID" value="ACU07329"/>
        <property type="gene ID" value="FIC_00876"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00876"/>
    <dbReference type="eggNOG" id="COG2057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_4_1_10"/>
    <dbReference type="OMA" id="VAMMHTN"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:3-oxoacid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="217" mass="23369" checksum="2132FD757F36BB94" modified="2009-09-22" version="1">MLTKEQIAQRISKEVKDRYYVNLGIGIPTLVANYVPQDIAVEFQSENGVLGMGPFPFEGEEDPDLINAGKQTITTLAGASFFDSAFSFGMIRSKKVDLTILGAMEVSENGDIANWKIPGKMVKGMGGAMDLVASAENIIVAMMHVNKAGESKILKKCTLPLTGVGCVKKVVTELAVMDVTPNGFKLLERAPGVSVEDIIKATEADLIIEGEIPEMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N2</accession>
    <name>C6X4N2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782516.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00919"/>
    <dbReference type="EnsemblBacteria" id="ACU07370">
        <property type="protein sequence ID" value="ACU07370"/>
        <property type="gene ID" value="FIC_00919"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00919"/>
    <dbReference type="eggNOG" id="ENOG5032WAT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089264_0_1_10"/>
    <dbReference type="OMA" id="WTAYTEL"/>
    <dbReference type="OrthoDB" id="1776310at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019619">
        <property type="entry name" value="DUF2490"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10677">
        <property type="entry name" value="DUF2490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973461" evidence="1">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="238" mass="27588" checksum="058F406B2EAF064F" modified="2009-09-22" version="1">MKKSYFTLFLFFIWAGFSAQSEHISSFNTVSVTYKFHPKFFALAEGQLRGIEDFAYPDYYEIKGGIGYNLTKNHKPFIGIGRFVTYADKVLDKEEFRVWLQDVIDLKAGKFKLENRFRAEKSWFYEPQTAENSDRIRLRYRLNISVPLNAESVKPGTLFANAYDEVFLVTTEKPLLARNRVFGGFGYQIDENFGIASGYLWQREFALSGNRNLHFLYLALNVTIDGSDEKNYEFPGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P3</accession>
    <name>C6X4P3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome C-type biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00930"/>
    <dbReference type="EnsemblBacteria" id="ACU07381">
        <property type="protein sequence ID" value="ACU07381"/>
        <property type="gene ID" value="FIC_00930"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00930"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008710_0_0_10"/>
    <dbReference type="OMA" id="SMLYIAW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="916"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="967"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1006"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="9">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="9">
        <location>
            <begin position="352"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="8">
        <location>
            <begin position="852"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123381" checksum="4BD23EB072019F7D" modified="2009-09-22" version="1">MQLFEFYYNFHMKKLQSILISTRTMAVLLLVYAVAMAYATFLENDYGTPTAKALIYEAKWFEAVMVLLILNFIGNISRYRLWKREKWPVLVFHLSFVLIFIGGAITRYISYEGIMHIREGETSNQVITDKNFFKIQIEEKGDILNYEDVPYLMSPLHKNFSASYDYHGKQVKVKAVDFIQRKKDSLVADNSGTEYLHVVSTGQSGRENIYIKSGESKSVNGMLVAFNRAIEGAVEFTNSGGQLLIKTPVEAEYMTMATQATGTTKKDEYQPLVLRSLYTVNDLKLVVPDGLKKGKLIAYEGDRQKDKEVSDQLTVELQGPKTKLLVDLPVEKGNPNAFKQVSLDGMNIIVGFGPKVYTTPFSLKLDDFVMETYPGSSSPSAYESHVQVIDNGKQTPYKIYMNNVLNHGGYRFFQASFDPDRQGTVLSVNHDFWGTLITYIGYFFLFGGMFVIFFWKGTHFWKLNKMLKDVNKKRTATVLLLLLSLTFNAQKIETHGTNDGSGKEMHSADDGHGHGAADLLTEEPAPKKTQNSLALKTPKSISPDVIISRNTINAEHAEKFGYLLVQNTEGRIVPINTQALDVLRKLYKSDKFKGTEGKFLTANQWFLSINTDTASWTMVPMIKIGSGGEALKKKARANAEGYTSLMNLFPADAQGNLHYVLEEDFQAAFAKKPADQSKYDLAVIDLNDRVQAFNEFFSGQFMRIVPVQNDPNNTWHSWLDQSFEPDMEAQKVMGPYFSEVLAAQKSGNWSKADAELAKLSEYQQTWGKNVVPSKSKVDLEVLMNKVNINFQLLIFYTLIGGLLLVLGFIELFKPNKILNKIVKGLILVGLIGYIFQFLGLVARWYISGHAPWSNGYEAIIFISWVGITAGLLLYRNSNALIPAAGFMVAVIMMGFAHGGSALDPQITPLVPVLKSYWLIIHVAIIVSSYGFFGLSMVIAIIVLMFYILSNKQAYKIHNDTTVKELTIVSEMSLTIGLYALVVGTFLGGIWANESWGRYWSWDPKETWAFISVMVYAFVLHMRLVPGLRGRWPYHVATLFAICTIVMTYFGVNYYLSGLHSYAAGDPVPVPAWVYIGLAFMFILSTLSYFRLKSLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q6</accession>
    <name>C6X4Q6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782540.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00943"/>
    <dbReference type="EnsemblBacteria" id="ACU07394">
        <property type="protein sequence ID" value="ACU07394"/>
        <property type="gene ID" value="FIC_00943"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00943"/>
    <dbReference type="eggNOG" id="ENOG5032RWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_2_0_10"/>
    <dbReference type="OMA" id="KMSIAYK"/>
    <dbReference type="OrthoDB" id="1986697at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035652">
        <property type="entry name" value="CHP02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="122" mass="13850" checksum="6BA93A840F423539" modified="2009-09-22" version="1">MGKDNLILDKSFSFALVVIDLYVKCRKQQEFVLSKQFLRSGTSIGSNVEESVAASSKKDFINKLRIANKEARETRYWFRLLNQSGLVDVNFDAALIEIESIINILTKIIKTSENNDDDSVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R4</accession>
    <name>C6X4R4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenylacetate-CoA oxygenase/reductase, PaaK subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782548.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00951"/>
    <dbReference type="EnsemblBacteria" id="ACU07402">
        <property type="protein sequence ID" value="ACU07402"/>
        <property type="gene ID" value="FIC_00951"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00951"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_14_1_10"/>
    <dbReference type="OMA" id="YVRIGVD"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="283"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="374" mass="43003" checksum="8971C93EA63C16E4" modified="2009-09-22" version="1">MEKQVPKARQAAFHPLKVAKKQQLTKSTFTLEFDIPETLKPNFRFDAGQYVTVRYKSRGKEVQNDYSMTSAPHEERLALGIKMGSAESSAGDLFNTINEGDILEVSEPQGRFTIVSKPHEFRTIVGFAGGIGITPLLSHFKNILHREPRTRLFLFYGNKRSEEIAFKKELDALTEQYRDRLQVWYFFSRENTPDHLFQGRLDEKKLHLIINQILHLDDTDEESTIWDAVDEVLICGKGDMIKSLANACYNNGIPKKNIHFELFEEYNEDIYPVEKEFPLVENIEVDFKLFNRSYSTVVPNNKIKLLQQLLIQNFPVPYSCKSGICGSCECVLEEGDVELLENEYLTEKEEKAGRILACMSVPLSKKIKINFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U4</accession>
    <name>C6X4U4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782578.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00981"/>
    <dbReference type="EnsemblBacteria" id="ACU07432">
        <property type="protein sequence ID" value="ACU07432"/>
        <property type="gene ID" value="FIC_00981"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00981"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146109_0_0_10"/>
    <dbReference type="OMA" id="HATHHTL"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="141" mass="16189" checksum="FA14CE7F7B2363EA" modified="2009-09-22" version="1">MQKLEFSVDINATADKVWQILFEKDNNGVWLAALDEGTTFEGTWAEGSIMKFLDAKNNGMYNLVETNVLHSELKMKHLGWIVDGQLNPMNWENSYVRYLLVTNEDGTLLKGEINSLDEFVSFFESKYPKNFLNIKELAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W8</accession>
    <name>C6X4W8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="8">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782602.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01006"/>
    <dbReference type="EnsemblBacteria" id="ACU07456">
        <property type="protein sequence ID" value="ACU07456"/>
        <property type="gene ID" value="FIC_01006"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01006"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_10"/>
    <dbReference type="OMA" id="DHWWHDL"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="5">
        <location>
            <begin position="71"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="519"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="635" mass="72104" checksum="D98C36886450CB42" modified="2009-09-22" version="1">MKNYFIDDLPDYFKQYKKSIKNPKKFWDKVADENFVWYQRWSKVVEYDMQEAKIKWFKNAKLNITKNCIDRHLNTRGDKTAIIWEPNDPKEEAQHISYSELRDRVCKMANVLRDMGIEKGDRVCIYLPMIPELAVTMLACARLGAVHSVIFAGFSASAVTSRVNDCEAKLIICSDGSYRGHKAIDLKGIIDEAVESCPTVEKVLVVKRTGGDVKMKDGRDFWLEPLYEKAASDFISVIMDAEDPLFILYTSGSTGKPKGMLHTTAGYMVYTAYTFKNVFNYQENDIYWCTADIGWITGHSYILYGPLANGATTVIFEGVPTYPEPDRFWEVIEKHKVTQFYTAPTAIRSLAKESYEWVEKHDLSSLRVIGSVGEPINDEAWHWYNDHVGKKKCPIVDTWWQTETGGIMISPIPFVTPTKPTYATLPLPGIQPVLMDDKRNEITGNQVDGNLCIRFPWPGIARTIWGDHQRYKETYFTAFPGKYFTGDGALRDEVGYYRITGRVDDVIIVSGHNLGTAPIEDSINQHPAVAESAIVGYPHDIKGSALYGYVILKDVGESRDRENLRKEINQVISDTVGPIAKLDKIQFVSALPKTRSGKIMRRILRKIAEGDFANFGDISTLLNPEIVEEIKEERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z3</accession>
    <name>C6X4Z3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01031"/>
    <dbReference type="EnsemblBacteria" id="ACU07481">
        <property type="protein sequence ID" value="ACU07481"/>
        <property type="gene ID" value="FIC_01031"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01031"/>
    <dbReference type="eggNOG" id="ENOG5032I2A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_542633_0_0_10"/>
    <dbReference type="OMA" id="AWYASFS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="502" mass="59619" checksum="13D18CF5B73657DB" modified="2009-09-22" version="1">MQVNLDTNLEKLFCLWYLYSLILHILHLSIRKMLRIYCDKNIYSLIKVNKKNYNHELKELMDELKDILIFTYSQAHHQDLSKSDSSFWEEDLLLLEDYVKDHYFNYDAIKKKTNCLLAKPTESFYDTDFSIAKNFLNPDNNLMDSLFATKEREEDDEFSKIAKNLFQNLLNIPIPNLHQTELTGKEKELSEKYLPNSENLTIGSVMEHFLKFGNKLLTDRQEVIGLKKMMEEYVNSDKYSFEKWKDQFDEKFKENFGGQSFTDLMKQTFEAVKDYNGYDKFVLFFNSLELHNVTKDKPLRKSQALESIHTDANHAWYASFSDVLVTDDKGLATKAYITYKFFEIQTKIFTTEEFLNNRTIFLQQEENDIKSFFKTLEFEIKNSLVLRNNINSFIENALILKNHHKFFNYFNRISHSKDSLKLYCQRHSNANFNMFREAKLLTDKLVTLFGIDVENKGYYNSEKDDPKDHMIRKWRFENIEVIFGIAFNNGGNCYCLDIEIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X517</accession>
    <name>C6X517_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805790.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01055"/>
    <dbReference type="EnsemblBacteria" id="ACU07505">
        <property type="protein sequence ID" value="ACU07505"/>
        <property type="gene ID" value="FIC_01055"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01055"/>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_11_0_10"/>
    <dbReference type="OMA" id="DCCVPDD"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="116" mass="12612" checksum="733E4F7C58697260" modified="2009-09-22" version="1">MAIRITDECINCGACEPECPNNAIYEGAVDWKASEGTALKGRVVMKSGLTVDADAPQEPVSDDIYFIVTDKCTECIGFHEEPQCAAVCPVDCCIPDEDHVESEESLLMKKAFLHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F9</accession>
    <name>C6X5F9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07647">
        <property type="protein sequence ID" value="ACU07647"/>
        <property type="gene ID" value="FIC_01199"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01199"/>
    <dbReference type="eggNOG" id="ENOG5032Z3K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118866_0_0_10"/>
    <dbReference type="OMA" id="MEMAYRI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032578">
        <property type="entry name" value="DUF4919"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16266">
        <property type="entry name" value="DUF4919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="248" mass="28599" checksum="0FB5B321BF85D614" modified="2009-09-22" version="1">MNSGYLQIIHLIIFTPPRHINIQILIELKSKTTMMTKLKLTAILLLFSFSAWGQIINFDSIKVNVQDENSAMYYEKLIYKFKFDPTLLSGEEVNHLYYGKKFSKYTTGLFDKDFGECSDNISSGNMKKAIIHGEKYLEKDPTNTEMLAYMEMAYRILENESKDHVLYIMKTKTLVDCILRSGDGKTKETAYIVNSIGEEYFIANVLGKNIGTYKRRSELQKDGAIDGFSKGKDSIFFKVYRTMEDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G1</accession>
    <name>C6X5G1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805934.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07649">
        <property type="protein sequence ID" value="ACU07649"/>
        <property type="gene ID" value="FIC_01201"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01201"/>
    <dbReference type="HOGENOM" id="CLU_2522656_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972339" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="85" mass="9061" checksum="EE2AF6420D17ED7D" modified="2009-09-22" version="1">MKKLITIIGVLAFTGIAQAQSESWFYNSEAEYKANVEAQSPGDGGLGGDDPLPAPIDDYIPLLLIAGLGMAVWYARQTQTETNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G9</accession>
    <name>C6X5G9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805942.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01209"/>
    <dbReference type="EnsemblBacteria" id="ACU07657">
        <property type="protein sequence ID" value="ACU07657"/>
        <property type="gene ID" value="FIC_01209"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01209"/>
    <dbReference type="eggNOG" id="ENOG50344BW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164503_0_0_10"/>
    <dbReference type="OrthoDB" id="1957263at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="238" mass="27468" checksum="A39834BD1357AE1A" modified="2009-09-22" version="1">MKVNFDITDNHALSIAGRHIDLHNNFDFVGFDYKVADREIKLHWKKSSGDWVDKNEFSSLVLTHSAVTFLKVIDQDEKSTYNDDSCLGEITFFPSTEREINDSIVPQSKPNDGDDILYFFENGQRIRIHCEKIELSVKLPIDTSDNNFTHSNLTEEEAFWVMRYFLDGHYELAGGEFDLTDILSATQPFEFDENGHFDGEVKGKRRIAPADSGMVWHWNEAVKKFREQGRPKPTPLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H6</accession>
    <name>C6X5H6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07664">
        <property type="protein sequence ID" value="ACU07664"/>
        <property type="gene ID" value="FIC_01216"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01216"/>
    <dbReference type="HOGENOM" id="CLU_1101596_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="252" mass="29259" checksum="2E9C6FFBE48F6079" modified="2009-09-22" version="1">MRKTIYILTLVILSSCNLYDRKEDVLMTDQDYVENYREFSPDSSMLLINYSLDLGAFGYGQSGTAILKLSDTTKNLRDFSLPNTLTRLKWLDNQTISAQFDILPSLRTGEKVALTDKEINGVKIKVSALDYINKDDHLEIEHRELSPNGQFELVAYRYLKDRSNLNFIHISVIPAGGQIPKYGNYLIADMQSDYVLNGTWTKKNELKFYSNSQYSDLIQYYLVNDREKIKYEIVTDDKEYGSKYRWTKKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K9</accession>
    <name>C6X5K9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-aspartate dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadX</name>
        <name evidence="9" type="ordered locus">FIC_01249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11788"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11784"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the L-aspartate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.21" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01249"/>
    <dbReference type="EnsemblBacteria" id="ACU07697">
        <property type="protein sequence ID" value="ACU07697"/>
        <property type="gene ID" value="FIC_01249"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01249"/>
    <dbReference type="eggNOG" id="COG1712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089550_1_0_10"/>
    <dbReference type="OMA" id="ECAGHSA"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033735">
        <property type="term" value="F:aspartate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01265">
        <property type="entry name" value="NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002811">
        <property type="entry name" value="Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020626">
        <property type="entry name" value="Asp_DH_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01958">
        <property type="entry name" value="DUF108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="8">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF108" evidence="7">
        <location>
            <begin position="188"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="279" mass="30335" checksum="206F8B60819F01BB" modified="2009-09-22" version="1">MRSRRFKFQYVRSMKTKTLAIVGCGKLAIIVSEALLKGLLPDFQLIATYSRTFEKAQRVADSVNRSDQGYRCTPCDSLEEIFALKPNYIVETASPASLKELAIPALKNGCSIVTLSIGAFANSAFYETVKQTALENGTRVHLASGAIGGFDVLRTVSLMEKSKVTFSTRKGPNSLKNTEVYDDSLQTQTREVFSGNAAAAIGLFPTRVNVAVAAALASNGPENVEVSIQSVPEFVGDEHRIEIESEQIRAVVEVYSKTAQIAGWSVVNTLRNITSPIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L1</accession>
    <name>C6X5L1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805984.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01251"/>
    <dbReference type="EnsemblBacteria" id="ACU07699">
        <property type="protein sequence ID" value="ACU07699"/>
        <property type="gene ID" value="FIC_01251"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01251"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030864_1_0_10"/>
    <dbReference type="OMA" id="WDEASEH"/>
    <dbReference type="OrthoDB" id="1536685at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="368"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="484" mass="55770" checksum="8DB858C022DC006D" modified="2009-09-22" version="1">MRYIYLVILLSGTLQAQLSSKETMGSAEKKSIELATQAIELFKKNDLKKSTELLFEAKEIAETTRNYELTAKIYGSIAHQYIQLKLNDKAKEYLQKAITEVNKLPENDTKITLKGLSYLDLGNIFFDEKKYEAANSNYKRSLKQFQLLSRPEPSVYHYRRSLYNIGRSFSFMKKNDSAEFYLNKALAVKDLKNRELKLYIYNALAQVYSDRGFTQRAVDSLKVALLDPQLQDAELKTEIYNNLAKNYRLQGNYKEYFAYNEKYINATESVKEKELSAINTAINAEQKDFRSVISRADQNYRRILSISAVLAIIFIGAIIYLILKRKREIKAFELMTSKLTALPSETTEKKIPSQPKDKTDYIPSPVETEILSRLEKFEASDKYINPKLNIANLAVQLATNTSYLSDVINKYKGKNFNTYINGLRIRYICDKIYNNPDYQKYKISYLAEECGFTSHSAFTTVFKNTTGISPSIFLREAAKKRTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5N5</accession>
    <name>C6X5N5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806008.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01275"/>
    <dbReference type="EnsemblBacteria" id="ACU07723">
        <property type="protein sequence ID" value="ACU07723"/>
        <property type="gene ID" value="FIC_01275"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01275"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_0_2_10"/>
    <dbReference type="OMA" id="ICQKDAF"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="260" mass="28273" checksum="6F9C970B322FE9FD" modified="2009-09-22" version="1">MNNHEIDYRIHGEEMQCVEIELDPNESVISEPGSFMMMTDGIQMQTMFGDGNEKGFMGKLLSAGKRVLTGENLFMTAFTNISNQKRQVSFAAPYSGKIIPLDLSELDGKVICQKDSFLCAAKGVAVDVEFQRKLGTGLFGGEGFIMQKLEGDGMTFVHSGGHVIEKQLQPGEILKIDTGCIVAFTKDVDYDIQFVGGIKNTIFGGEGLFFAQLRGPGKVWIQTLPIARLAARILQFGTTKKGEEGSLLGGLGRIIDGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T6</accession>
    <name>C6X5T6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806059.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01326"/>
    <dbReference type="EnsemblBacteria" id="ACU07774">
        <property type="protein sequence ID" value="ACU07774"/>
        <property type="gene ID" value="FIC_01326"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01326"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_13_0_10"/>
    <dbReference type="OMA" id="QWNEHYP"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="19254" checksum="EF504F0F7ED2B1DE" modified="2009-09-22" version="1">MSDKDYNFRRANSTDEPQILTILQQAIERRRLDGSQQWQDGYPNPETVTSDIAKGWGYVIEIENSVAAYVSIIYEPEPAYEAIDGSWLSTGEYVVMHRVAVADEFTGRGLATEIFREAENIAKRSGVSSIKVDTNFDNVALLHILKKLGYKYCGEVYFRGSARKAFEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W4</accession>
    <name>C6X5W4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S1/P1 endonuclease family protein</fullName>
            <ecNumber evidence="7">3.1.30.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.30.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806087.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01354"/>
    <dbReference type="EnsemblBacteria" id="ACU07802">
        <property type="protein sequence ID" value="ACU07802"/>
        <property type="gene ID" value="FIC_01354"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01354"/>
    <dbReference type="eggNOG" id="ENOG502Z82C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044365_1_0_10"/>
    <dbReference type="OMA" id="GYRLANW"/>
    <dbReference type="OrthoDB" id="1079090at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="PTHR33146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973729" evidence="6">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="263" mass="29949" checksum="8625119FD7FEB95D" modified="2009-09-22" version="1">MTNFFKNLVLFAALVSFSNAYSYGVTGHRVVAEIAENHLSNKARKNLKKIIGNQKLAYWANWPDAIKSDTTGVWKQTDTWHYVNISPQADLKSFSDSLQAQTGPNLYTQIKTLSAQIKDKKTSAKDREIALRFLIHLVGDSSQPMHVGRAGDLGGNTIKLKFFGENTNLHSLWDSKLVDFQKYSYEEFAKVLDVKSKEEVRAIQSGTLEEWFYDSHLKANNIYANTVADKSYSYDYNYKYAPLLERQLLYGGLRLAKILNDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X8</accession>
    <name>C6X5X8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01368"/>
    <dbReference type="EnsemblBacteria" id="ACU07816">
        <property type="protein sequence ID" value="ACU07816"/>
        <property type="gene ID" value="FIC_01368"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01368"/>
    <dbReference type="HOGENOM" id="CLU_2824795_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="66" mass="7375" checksum="57B5F14C8FA010E1" modified="2009-09-22" version="1">MQRILSLKNSIMKLLFGLAILGAMFLTACVQKEEKRDEFKENHSVDEKRNAGVDSAALEPSQPVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z3</accession>
    <name>C6X5Z3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoisovalerate dehydrogenase, E1 component, alpha and beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806116.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01383"/>
    <dbReference type="EnsemblBacteria" id="ACU07831">
        <property type="protein sequence ID" value="ACU07831"/>
        <property type="gene ID" value="FIC_01383"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01383"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_2_1_10"/>
    <dbReference type="OMA" id="YRNPMVV"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="3">
        <location>
            <begin position="354"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="690" mass="76720" checksum="93D83355C0D7D380" modified="2009-09-22" version="1">MEIDTQHKVSQEILLKAFNHMMLAKAMADIYEENRSITTYVHSTSRGHEAIQLATAYQLTKEDWVSPYYRDDSLLLGIGFEPYRLMLQLLAKADDPFSGGRSYYSHPSSLEENLPKIIHQSSATGMQAIPTTGVAQGIKYIQEFNLKTYENNPIAICSMGDNSVTEGEVSEAFQFAALHQLPIIFLVQDNEWGISVTKEEARTSDAYEFVAGFTGLNRVRVDGTDFVASYEAMKKAVDFVREEGQPVVVCAKTVLIGHHTSGVRREFYRDEENLTTHRAKDPGVILRKRLIEDGVAENILNEIEKNARQQAEKDFKKAIAAEDPKPDTVKNHIFAPTPVTEETGTRVPENQEKIVMVDAAIHAIQEIMWKHPEALLYGQDVGERIGGVFRETVTLGKKFGKKRVFNTPIQEAYIIGSTVGMSAVGLKPIVEVQFADYIYPGINQLITEISKSNYLSNGKFPVSNIIRVPIGAYGGGGPYHSGSVESILANIKGIKIAYPSNAADFKGLLKAAYYDPNPVIMLEHKGLYWSKVPGTEDAKTIEPAEDYILPLGKGNVIVEADRSETDKGRSMLVVTYGMGVYWAKEAAKNFPGQVEIIDLRTLIPLDEDLVFKSVKKHGKCLVLTEEQLNNSFAEAFAHRISKNCFKYLDAPVEAMGAMDLPAVPINLILEKEMLPNASKVSDRIREMLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X612</accession>
    <name>C6X612_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="2 7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pdhA</name>
        <name evidence="9" type="ordered locus">FIC_01402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01402"/>
    <dbReference type="EnsemblBacteria" id="ACU07850">
        <property type="protein sequence ID" value="ACU07850"/>
        <property type="gene ID" value="FIC_01402"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01402"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_0_10"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="8">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="339" mass="38793" checksum="420AB57A36E914CA" modified="2009-09-22" version="1">MRLNMKEFSKEVYLKWYEEMTMWRRFEDKCRSLYLKQKIRGFLHLYNGQEAIPAGFTHAMDLTKDSMITAYRCHIHPMAMGVDPKRILAELCGKATGTSGGMGGSMHIFSKEKRFYGGHGIVGGQIPLGAGIAFADKYFETGGVNICFFGDGAARQGSLHETFNMAMNWKLPVVFVVENNQYAMGTSVKRTANHEDIYKLGLGYEMPCLPVDAMDPEKVAEAAFEAIERARRGDGPTFIEARTYRFRGHSMSDAEAYRSKDEVAEYKKDDPIEIVKHRILENSWATEDELTAIDEKSKEFVEECVEFMEQSPYPTAEKVYEYVYAQENYPFLDKYENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X633</accession>
    <name>C6X633_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01423"/>
    <dbReference type="EnsemblBacteria" id="ACU07871">
        <property type="protein sequence ID" value="ACU07871"/>
        <property type="gene ID" value="FIC_01423"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01423"/>
    <dbReference type="eggNOG" id="ENOG503306B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2341698_0_0_10"/>
    <dbReference type="OrthoDB" id="2080110at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="111" mass="12399" checksum="9A11E4F2159CA32E" modified="2009-09-22" version="1">MTKSPKYTIMSTDENEKEQERKLEEMDYNPSDDIFTKHNPVRLDGDGNPITAERGNDGMPYGLDVPGAADDDNYEQIIDQLPADDGSKTQSPSLTANDLEPDSEDVARYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X652</accession>
    <name>C6X652_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806175.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01442"/>
    <dbReference type="EnsemblBacteria" id="ACU07890">
        <property type="protein sequence ID" value="ACU07890"/>
        <property type="gene ID" value="FIC_01442"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01442"/>
    <dbReference type="eggNOG" id="ENOG5033MTV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200994_0_0_10"/>
    <dbReference type="OMA" id="YLYEIEL"/>
    <dbReference type="OrthoDB" id="1969631at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="75" mass="8576" checksum="2F7B32B6C96C0774" modified="2009-09-22" version="1">MSELVPIFQSSYLYEIELAKSKLASREIPSYIKNEYVNNIAVFPISQNYFLLVSERDFAAAEQILAESHESEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C4</accession>
    <name>C6X6C4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M4, thermolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806247.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01515"/>
    <dbReference type="EnsemblBacteria" id="ACU07962">
        <property type="protein sequence ID" value="ACU07962"/>
        <property type="gene ID" value="FIC_01515"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01515"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500341_0_0_10"/>
    <dbReference type="OMA" id="NGAWESS"/>
    <dbReference type="OrthoDB" id="835388at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011628">
        <property type="entry name" value="Cleaved_adhesin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07675">
        <property type="entry name" value="Cleaved_Adhesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973646" evidence="1">
        <location>
            <begin position="22"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="221"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="544" mass="57942" checksum="A0F91DF22392B5D2" modified="2009-09-22" version="1">MKKLLFSLCAAGALMASDVMKGQTVLFEDSFETYADFAIADVGAWTLIDVDQKTTYGFNGVTFPNTGVAKSFQVFNSTTTTPPLDPTTTSNWTARTGQKMMVSFAATSAPWNNDWMVSPQVQIGAGEGATLSFWAKSCDATYGLEKFTVYVSTTGTAVADFTAISPVTVTPSDATWYEYTYSLNAYSGQPVHIAIQTTSDDQFGFAVDDFRVVSNPLPAVAPECPTLNAPANAATNVSYTSVNLTWTANTQGGTADSYDVYLDTNANPTTLVGNTTSTSYTATNLTGSTTYYWRIVPKNIVGSAASCTVYSFTTAAPAYCTAGATSTSFEKISNVTFAGINNSSTATVGYEDFTAVSGAVTAGNTYPFSATFSGTSYSSDQVMVWIDFNNDKDFNDAGEQVLITPTKVSPWTGDIVIPADVAAGTVRMRVRLHDSSLGGNLTPCGTSTYGQVEDYTLNISTLGVNDTVKNAVKVYPNPVVDILNIDSPSKVKSIRVFDVTGRTVSTHVLNAEKSQVNLSGLASGVYMVSIQMENETRTVKVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F0</accession>
    <name>C6X6F0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01541"/>
    <dbReference type="EnsemblBacteria" id="ACU07988">
        <property type="protein sequence ID" value="ACU07988"/>
        <property type="gene ID" value="FIC_01541"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01541"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045539_4_2_10"/>
    <dbReference type="OMA" id="KQPKFRW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="338" mass="38626" checksum="277267F4C5C3D946" modified="2009-09-22" version="1">MTCKYRLMGIKTPKFLLKIHTYLDDLHIPFLGISLWKMFEIYGQGVFKMQIGRSAASISWSFFLSLFPFILFLLSLLPYLPHYDKLQFYIFEVLMLNVFPAHIQQEVSGYINSFIIPNMQNISTLTIVFAMVFAVNGTHSLINGFNLNTNLQRGAVKEYFVAFGITIAFIFLIIASLFGVYYSEVVLKLFTPEINISWLVRNMTKIIGFISFPVFYLILLALFYWVGCLKITSFKQALPGAVLTTLLFIVLTYFFAIYVRNFATYNVLYGSIGTIILVMIWVNLNIILILLGNELNIAIKKVRVEKMIADEINAGTLELNPEIISALEDTDESHTVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG4</accession>
    <name>C6WZG4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781646.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00021"/>
    <dbReference type="EnsemblBacteria" id="ACU06499">
        <property type="protein sequence ID" value="ACU06499"/>
        <property type="gene ID" value="FIC_00021"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00021"/>
    <dbReference type="eggNOG" id="COG2346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104957_3_1_10"/>
    <dbReference type="OMA" id="RIAWAMH"/>
    <dbReference type="OrthoDB" id="1697277at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="14722" checksum="EDDA5E0EDE6E1CB0" modified="2009-09-22" version="1">MKKLESREDIELLVNKFYEKVGQDETIGFFFNDVARVNWGHHLPKMYGFWETLLFGQISYKGNPMAVHFPINEKVAIEKHHFAHWLRLWTETVEENFTGEIADMAINKATNIANLMAHKMEIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI0</accession>
    <name>C6WZI0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein containing DUF885</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781662.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00037"/>
    <dbReference type="EnsemblBacteria" id="ACU06515">
        <property type="protein sequence ID" value="ACU06515"/>
        <property type="gene ID" value="FIC_00037"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00037"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018914_1_0_10"/>
    <dbReference type="OMA" id="GRMWWAV"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="596" mass="68282" checksum="DA750762A95E3BEC" modified="2009-09-22" version="1">MGKTVFHAFIITVFFSLFSCKKTDYPLTRETPVEIDSIAANYYEQYLKLYPLEATAQGDLRYNDQLPVNIDKDFISGEISFYNSVQAQLKKVDYEKLTDEKKTVYDVLDYTLKDKIERYAYHPEYIPFTQFGGLPLDFPLLGSGQGSQPFKTEKDYSDWLSRAEKFPLWMDTAMANFREGITQKYILPKTLVAKMIPQMKAEEITTTDFDRNIFYGPIKNFPKNFTAAQREKFTSQYKALITEKIIPTYLKMANFLEQEYLPKARNTHGINSLPNGGEIYSYYAKSWTTTSLTPQDINRTGLAEVARLRAEMEKVRKQVNYNGTLEEFIAHVKTDPKAFPYTSSKEVLDGFNGILKKITPKLKTMFSVAPKTAFEIRQTEKFREASASAEYMPGTPDGKRPGIFYIPIPDPTKFNVTSGMESLFLHEAIPGHHYQISLQQENTSLPKFMRFGWFGAYGEGWALYCESLGPEFGLYTDPYQKMGSLSDEMLRAVRLVVDTGLHSGTMTREEAITYFLSNISYDEAAATAEVERYMAMPGQALSYKIGSLKIRALRDQYQKELGNKFSLAKFHDEVLNQGGLPLDVLDRKMKLWAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM3</accession>
    <name>C6WZM3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781705.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00082"/>
    <dbReference type="EnsemblBacteria" id="ACU06558">
        <property type="protein sequence ID" value="ACU06558"/>
        <property type="gene ID" value="FIC_00082"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00082"/>
    <dbReference type="HOGENOM" id="CLU_1136729_0_0_10"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973512" evidence="1">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="244" mass="28158" checksum="8981D81258BE6375" modified="2009-09-22" version="1">MKKIFLLLLLSPLIVYGQAQVLDGYPDHQSPYVGGYSAYYKDFHDIIVEKKLQPCANPSEFYQFSVLINADASINFIKDQHADYLSANKCAADLAREVAKHMTKWNPATLNGVKQAAVARFNIFPAQLFEDEHSDYTPSVTGPVYNNAGDNHMEHFRKQLKANLNLKRFSWEDRFTVEAEFIITKEGKLEDIVLTKKTGLEEFDRMVFYAYRAMKKKWIPATVNGKPVDYRYKYQLTAITELEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN0</accession>
    <name>C6WZN0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781712.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00089"/>
    <dbReference type="EnsemblBacteria" id="ACU06565">
        <property type="protein sequence ID" value="ACU06565"/>
        <property type="gene ID" value="FIC_00089"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00089"/>
    <dbReference type="eggNOG" id="ENOG502ZGYE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2047942_0_0_10"/>
    <dbReference type="OMA" id="ITIVYFA"/>
    <dbReference type="OrthoDB" id="2006533at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970470" evidence="2">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="123" mass="13174" checksum="607A27E21D5EACE5" modified="2009-09-22" version="1">MKNIILGAFAFFVLAACTKSAEGNGAENKTIEAELVQKPVEFKNASGEAISVTYYSEGDVVAVKITPQGKAEQKLVAKTVNRNGNPVFTNDQYMWEITQDGQAGTLSDGAGNTTEYMKTESAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN5</accession>
    <name>C6WZN5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781717.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00094"/>
    <dbReference type="EnsemblBacteria" id="ACU06570">
        <property type="protein sequence ID" value="ACU06570"/>
        <property type="gene ID" value="FIC_00094"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00094"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123301_1_0_10"/>
    <dbReference type="OMA" id="LGARYFF"/>
    <dbReference type="OrthoDB" id="1650612at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973513" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="146" mass="16013" checksum="33084AEF6FBA6B7D" modified="2009-09-22" version="1">MKKLLLVCSMFFLGQTAFAQAWNGKGDQKLQVGFNGWGYGNGITATYDYGLGSIVSLGAGANFYFDGYKDNNEDNNVFLFGRLGFHLQEPLGLPEQWDIYPGVNLGILGKDFGFGAHLGVRYFFNENVGIYGEFGNNGSLGVSFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR1</accession>
    <name>C6WZR1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00121"/>
    <dbReference type="EnsemblBacteria" id="ACU06596">
        <property type="protein sequence ID" value="ACU06596"/>
        <property type="gene ID" value="FIC_00121"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00121"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082049_5_0_10"/>
    <dbReference type="OMA" id="GIDLRYE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044384">
        <property type="term" value="C:host outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000758">
        <property type="entry name" value="Enterovir_OMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00695">
        <property type="entry name" value="ENT_VIR_OMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973516" description="OMP_b-brl_2 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="66"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="24276" checksum="FB6E35055D53FF35" modified="2009-09-22" version="1">MITLLPILRKMNKIFSIALLGASFFASAQISLAGKANVLIPTSSATWQNFKDAAGTAVAEKGKNITGFNVGLSLKADLPMSLYLMPEIYYSTFKNEATVTDAMGNETIIEAKTNRIDVPVLLGYRLLGNTLSAFAGPVGTFNLNEGETFRSFVEQVETKNFTVGYQFGLQSELKNLIISAKYEGAFSKDQRKFVTTIADADQEIEYDNRPSLFMLGLGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR4</accession>
    <name>C6WZR4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781746.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00124"/>
    <dbReference type="EnsemblBacteria" id="ACU06599">
        <property type="protein sequence ID" value="ACU06599"/>
        <property type="gene ID" value="FIC_00124"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00124"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_0_1_10"/>
    <dbReference type="OMA" id="FKQKRNG"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="263"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="455" mass="53351" checksum="685E9BA354E6A919" modified="2009-09-22" version="1">MQKIRYSRYFKVIFIVLDVLVIAGVFLFYFLRNRTVEYAQDVWEQNFFSVIALVLFWILLSGRTRLYSVARNLTYTIYLERLVTHIFIFIFGVILLAKVSNNEFLKQDRFLIAITLFFLLFFVKSIVFFTLKYLRTLGINYRNIMFINDDPSSKILKNILTERKDYGFRIFEFPAEDHYNLQKLIEFWKINGIHTMYLSSNGFSKDEEEEIYRQAERHKVRVSLIPSIAKNNFFQYDLGYIEMQPVLVRSKFPLDFLTNIIIKRTFDIAFSLFMLIVIGTWLFPLIALLIKLDGKGPVFFKQKRYGFHDEVFSCLKFRTMHVNGDSANKTTTENDKRITKIGKFLRKTSLDEMPQFINVLKGEMSVVGPRPHMLLVDDFYKLKIGRYSVRSLVRPGVTGLAQVNGLRGDAGDMEIQMHKRILADAFYVKNWSFTLDLVIILKTAFLVIGGDKNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR7</accession>
    <name>C6WZR7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ordered locus">FIC_00127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781749.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00127"/>
    <dbReference type="EnsemblBacteria" id="ACU06602">
        <property type="protein sequence ID" value="ACU06602"/>
        <property type="gene ID" value="FIC_00127"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00127"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_10"/>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="546" mass="61364" checksum="F1E85304FFA9A2EF" modified="2009-09-22" version="1">MLPKINPEQTKAWQNLEDHFAHNDFELRTLFQYNTNRFNEFSVKREGYLFDFSKNLIDQRTLDLLLKLAEETKLKEAISAMFSGEKINETEGRAVLHTALRDFSGEPLLVDGEDIKPGIKKVLDQMKAFSDKVISGDHKGFSGKQITDVVNIGIGGSDLGPVMVCSALKHFKTRLNVHFVSNVDGNHIAETLKNLNPETTLFIIASKTFTTQETMTNAASGKEWFLKSGSEQDVAKHFVALSTNIKSVKEFGIAEENIFEFWDWVGGRYSLWSAIGLSIVLAVGYDNFEQLLKGAAESDNHFRTADFKENVPVLMALLGIWYRNFYSAGTYATLPYSQYLNRFPAYLQQGDMESNGKSVDRNGNYVEYETGPIIWGEPGTNGQHAFYQLIHQGTELIPADFLAYAKSCNEVSDHQDKLLANFFAQTEALAFGKTDEEVRAELETAGKSEEEIAKLLNFKVFTGDSPTNSFIFDELTPFSLGQLIALYEHKIFVQGAIWNIFSFDQFGVELGKVLAGKILAELENKEEVTTHDSSTNGLMNYYQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZS2</accession>
    <name>C6WZS2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane [4Fe-4S] cluster-binding oxidoredu ctase</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781754.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00132"/>
    <dbReference type="EnsemblBacteria" id="ACU06607">
        <property type="protein sequence ID" value="ACU06607"/>
        <property type="gene ID" value="FIC_00132"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00132"/>
    <dbReference type="eggNOG" id="COG1150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619292_0_0_10"/>
    <dbReference type="OMA" id="IMMDTRD"/>
    <dbReference type="OrthoDB" id="624150at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="442" mass="50185" checksum="282E07BE97137D20" modified="2009-09-22" version="1">MQYIDNIIFIIALIVGFRLFFKSLKEIYRNILLGRKIDRSDRPAERWATMGKVALGQSKMTKRPIAGILHIIVYVGFVIINLELLEIIIDGVFGTHRFLAGIFGNSFYNAFTATLEILALLVVLAVVVFFIRRNFYGVKRLTMKELFGWPKQDANWILIIEFALMAAFFTMNAADWSLQQKGAGEALGYYPVSSAVLGPLFGNFSEGALVILERGAWWFHFIGILFFMNYLYYSKHLHIIFAFPNTWFANLEKKGKFNNLASVTQEIKLMMDPNADPYAAAPEADPNAVPEKFGADDIFDLNQVQLLNAYSCTECGRCTAVCPANITGKKLSPRKIMMDTRDRLEEVGKNINKNGKFVDDGKKLIDDHIQREEIWACTTCNACVEACPVLIDPLSIIMEMRRFLVMEQSAAPQELNLMMTNVENNAAPWQYNQADRLKWASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU0</accession>
    <name>C6WZU0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="9" type="ordered locus">FIC_00150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781772.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00150"/>
    <dbReference type="EnsemblBacteria" id="ACU06625">
        <property type="protein sequence ID" value="ACU06625"/>
        <property type="gene ID" value="FIC_00150"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00150"/>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_10"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="916845at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="51"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="271" mass="29624" checksum="4A3ECA207F38CC6D" modified="2009-09-22" version="1">MSVHSEIKKITTETLRKMKFDKEKITMLTAYDFTTAKMVDAGGVDSILIGDSAANVMAGFETTLPITLDQMIYHTQCVVRGVERALVVADLPFGSYQSNSEKALESAVRMMKEGGAHAIKVEGGIEIEKSIKKIINAGIPVMGHLGLTPQSIYQFGTYKVRAKEDAEAEKLLKDAKLLEELGCFAVVLEKIPADLAKLVSESISIPTIGIGAGPDCDGQVLVYHDMVGMNKGFSPKFLRRYLDLYTEITGAVSQYVKDVKSADFPNQNESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X004</accession>
    <name>C6X004_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781836.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00215"/>
    <dbReference type="EnsemblBacteria" id="ACU06689">
        <property type="protein sequence ID" value="ACU06689"/>
        <property type="gene ID" value="FIC_00215"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00215"/>
    <dbReference type="eggNOG" id="ENOG5033A0F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123838_0_0_10"/>
    <dbReference type="OMA" id="VYILWDQ"/>
    <dbReference type="OrthoDB" id="2029554at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970490" evidence="1">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="18884" checksum="D92E5F2D95694F11" modified="2009-09-22" version="1">MKKYFSILLLAIFAFVAFSCDDRDDSVLVDDNDTYPVMADITGNFNAGNSYTINQGIDIASSDVVLVYRNINSGNSGTPAWQQIPKTEFLSNGRELDYNFLFDSQNVEIYTEANFDQATFTSAEATSYLNNQRFRIVLIPASQQKNANVNYSDYESVIKFYNIPDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X044</accession>
    <name>C6X044_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00256"/>
    <dbReference type="EnsemblBacteria" id="ACU06729">
        <property type="protein sequence ID" value="ACU06729"/>
        <property type="gene ID" value="FIC_00256"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00256"/>
    <dbReference type="eggNOG" id="ENOG502ZYG3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107087_0_0_10"/>
    <dbReference type="OMA" id="AHKFYVS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="208" mass="24505" checksum="A66F32F2EBB75D06" modified="2009-09-22" version="1">MKHDNTKYILTLLKLQLEELVVIAATETTKNFRIIKMNKFFTAFLLLFTVIAISAADFRESDIHPYHVGSVEMKYNSTSKTFEVSTRFFLDDLENALKDKYGKPVRFHDQKYKQEIDRLLLKYCEDYLKIKADGKFIKINYLGYEEDSEAVNIYLESEKISAPKKVEAAVSFLYNLFDDQMNIIHIIVGGKRESDRLTYPDRYLYRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X068</accession>
    <name>C6X068_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781900.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00285"/>
    <dbReference type="EnsemblBacteria" id="ACU06753">
        <property type="protein sequence ID" value="ACU06753"/>
        <property type="gene ID" value="FIC_00285"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00285"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_9_0_10"/>
    <dbReference type="OMA" id="APGSDQM"/>
    <dbReference type="OrthoDB" id="1003376at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="332" mass="37093" checksum="211AFB6CF62E63A4" modified="2009-09-22" version="1">MKNFELSVLDLAPVKQHKTINDTFNDSLDLARHVETLDYRRFWLAEHHNMASIASSATSVLIGFIANGTQKIRVGSGGVMLPNHSSLVIAEQFGTLESLFPNRIDLGVGRAPGTDGLTAKALGRNPMIINEQFPRQIRELQQYFSVENATSLVRAIPGEGCDIPIYVLGSSTDSAWLAAEYGLPYAFAGHFAPDMMGSAFEIYRENYKPSEEFPEPYIIACANGIAGETDDEAKKLSSTLYQMFINIIRNDRKPYSPPVEDMDALWNPMEKAHVTKMLRHSFIGSESSVAQQLKEFQDTFKVDEIMITSAIYDHEARLKSYGIIRKAADFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X073</accession>
    <name>C6X073_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol:disulfide interchange protein tlpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781905.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00291"/>
    <dbReference type="EnsemblBacteria" id="ACU06758">
        <property type="protein sequence ID" value="ACU06758"/>
        <property type="gene ID" value="FIC_00291"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00291"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_0_10"/>
    <dbReference type="OMA" id="NKYLICI"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="35"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="183" mass="21022" checksum="D4D65C090F2B7C03" modified="2009-09-22" version="1">MTFIKKNIFSIIAIAFVAVLYLFPSVKLKIKDLFFPVAAIENAVTLQDSDYDLQLKGINVASTNLKNLKGDKLVFLNFWGTWCPPCREEWPTIEKLYQARKDKIDFVLIAMQDEEEKVVKFMKENNYTAPVYIAQSPISKNILPKAFPTTFLLTKDGRILLKEDSSKDWNSKSVNDFIDNVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G2</accession>
    <name>C6X0G2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781995.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00381"/>
    <dbReference type="EnsemblBacteria" id="ACU06848">
        <property type="protein sequence ID" value="ACU06848"/>
        <property type="gene ID" value="FIC_00381"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00381"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056342_3_0_10"/>
    <dbReference type="OMA" id="HMGDLFF"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="58"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="306" mass="34097" checksum="8FBCB63F1A2C17E7" modified="2009-09-22" version="1">MIRKEFLATTFSAGLGLALMPTILSCTTQRMLFPPMIQPAGGDLKGVRGNVSRYTNKGGTIGVLETKDGFVIIDSQFADSVQPLLNVISAKGKPVLYLCNTHHHGDHTSGNVAFKDPNTKVVAHSRVPELQRLAAEKSNKVAEQRFPTLLFDDTYEINIGREKITAHHFGNGHTFGDAMYHFENDNVVHMGDLMFINMIPVYRTADGSDSRSWIKVLEKAQSTFDDDTVFIFGHANKPELTTGTKKDLKEMANFLEASNGFIRKAIREGKTTEQLLTENKFIPGFENRTTPDRFPGFLTELRKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I6</accession>
    <name>C6X0I6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flagellar motor protein MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00405"/>
    <dbReference type="EnsemblBacteria" id="ACU06872">
        <property type="protein sequence ID" value="ACU06872"/>
        <property type="gene ID" value="FIC_00405"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00405"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_14_0_10"/>
    <dbReference type="OMA" id="PKIDQFY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="2">
        <location>
            <begin position="163"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="300" mass="33136" checksum="6C20EDA52E4B1C8A" modified="2009-09-22" version="1">MAKIILPFRMNFLFLAELKEILMRTGKIFAIVVMALTMTSCVSRKQFDALNENYNQCITNIGERQREIQDLKSVNSGLTSENNLLKSQNDALKSSLDACLSNTGKGSANIDKLIGEINSSNKYIQQLISTNAKNDSLNLALSNKLKRSLDNIADDDVQVKVLKGVVMISLSDKMLYKTGDYNVMPAAQEVLGKVAQVINDYDTYSVLIEGNTDNVPLSSANLPKDNWDLSALRATSMAKILQTKFGVNPARITAGGRSEYNPKTTNASVSGRAENRRTEIIIMPKLDEFMKLMDIAPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J6</accession>
    <name>C6X0J6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782029.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00415"/>
    <dbReference type="EnsemblBacteria" id="ACU06882">
        <property type="protein sequence ID" value="ACU06882"/>
        <property type="gene ID" value="FIC_00415"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00415"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117507_0_0_10"/>
    <dbReference type="OMA" id="TAMCDVA"/>
    <dbReference type="OrthoDB" id="1537812at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="200" mass="22680" checksum="5962C8DE194C7B56" modified="2009-09-22" version="1">MARVKPKRHNIRVDMTAMTDVSFLLLTFFILTAQFAKPDVETITTPSSISEKLLPDASLMTVLTTTDGKFYFTPVENGSERMQLLDKMGEKYGMQFTDKEKVSFTKVQAIGVPMNQLKGFLNLSDEEQKAYKSPTGIPMDSTNKQVIDWVQQSLAVNPDYKMAIKGDVQTEYPKVKALFEGLRDIDFLKFWLITSQETAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M1</accession>
    <name>C6X0M1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00445"/>
    <dbReference type="EnsemblBacteria" id="ACU06907">
        <property type="protein sequence ID" value="ACU06907"/>
        <property type="gene ID" value="FIC_00445"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00445"/>
    <dbReference type="HOGENOM" id="CLU_3118081_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="50" mass="5593" checksum="EBAE53906CACDA5D" modified="2009-09-22" version="1">MMGKKFSALAIFSAKVSVDISVILDMPNYEKFGVFEILAFHPCFVARHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0T3</accession>
    <name>C6X0T3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01600"/>
    <dbReference type="EnsemblBacteria" id="ACU08046">
        <property type="protein sequence ID" value="ACU08046"/>
        <property type="gene ID" value="FIC_01600"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01600"/>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067293_1_0_10"/>
    <dbReference type="OMA" id="WASAMAL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="197" mass="21809" checksum="A5E64494AD9F0C1D" modified="2009-09-22" version="1">MLGFVIYTGRSIFTKDKTEADGFVEKIGWWFVISCVANCLWIVTWLYGYTGLSVVILAVLLVALLIILLTALQYKRNAAEKWLINIPFQIYSGWISVALIAAAASWLQKIGWDGWGLSEVTWTVIMISVAVLVHLYMTWIKNAPVFALVAVWALIAIAVCNQSENLTVYAVALGAAGVVLVSCVLHFIRRKAKLQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y9</accession>
    <name>C6X0Y9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806387.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01658"/>
    <dbReference type="EnsemblBacteria" id="ACU08102">
        <property type="protein sequence ID" value="ACU08102"/>
        <property type="gene ID" value="FIC_01658"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01658"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053649_0_0_10"/>
    <dbReference type="OMA" id="PMGFSDK"/>
    <dbReference type="OrthoDB" id="884913at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="389" mass="45436" checksum="D28301E8614315AD" modified="2009-09-22" version="1">MPKVSLIEVKTARDLDMFVRFPMELYKNNKNYVPPLINDEKSIWNPGENPALSYSEAKQLLAYKEGKLVGRIALIINRKEEKELGISKVRFGWLDFIDDFEVSEALIEAAKNFAKTHRINKIEGPMGFTNLDKSGMLTMGFDKLATMIGLYNFPYYPQHLEKLGLVKEKEWVEFEMNFPTVLPEKVDRFSSLIAEKFKLKVIDFKSKKEILPYIEPMFKLLDQTYNSLSTYTPITDEQITTYREKYFPFIDKNYVICVEDENHQLVSFAVTMPSYSKALQKSKGKLWPFGWWHFLQAGKKNDRANFYLIGIHPEYQRRGVTAIIFKEIFIRFNKMGIKFAETNPELEENKSVQLLWLDYNPVCHKRRRTYSLEIEASGDGMTNDPAVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X103</accession>
    <name>C6X103_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase chain M</fullName>
            <ecNumber evidence="8">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806401.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01672"/>
    <dbReference type="EnsemblBacteria" id="ACU08116">
        <property type="protein sequence ID" value="ACU08116"/>
        <property type="gene ID" value="FIC_01672"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01672"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_3_10"/>
    <dbReference type="OMA" id="ITRWGNQ"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000260">
        <property type="entry name" value="NADH4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01059">
        <property type="entry name" value="Oxidored_q5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q5_N" evidence="7">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="131"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="497" mass="55007" checksum="0E53995DF1335355" modified="2009-09-22" version="1">MSYLLLTFLLLPLVGSAVVFAWKNPASKFLALGFAFAQMFLTLYMLAGLDFKPTVDGVLQYEINYPWSQFIRSNLHFGIDGMSMLMLLLTNILTPLIILSSFNEKPGYRNTFYGLILLMQFGLIGIFTALDGLLFYIFWEVTLIPIWLIAGIWGQENKKIEFTTRFFVYTFVGSLFMLLGLIFVYTNSASFALTDLYNAQLNTTEQTVVFWFIFFAFAVKLPVFPFHSWQADTYTYSPTQGTMLLSGIMLKMAVYGLLRYLLPITPDPVLGISGQIVLVLAIVGIVHGALIAIAHNDTKRILAYSSLSHVGLMVAGIMASAIVTMKGSLSTQGGEGAMVQAFAHGINIVGLFYCADILYKRFKTRDIRQMGGLAKVAPKFAVLFMIILLGSIGLPLTNGFIGEFILIKSIFDYNKLAAVVAGLTMIFSAVYLFRMYGKAMFGEGDERVLSSAEDLSGIEFSVLATLAGFVILFGVFPQPLIDMVSSSLKFIYASMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X149</accession>
    <name>C6X149_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01719"/>
    <dbReference type="EnsemblBacteria" id="ACU08162">
        <property type="protein sequence ID" value="ACU08162"/>
        <property type="gene ID" value="FIC_01719"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01719"/>
    <dbReference type="HOGENOM" id="CLU_3396632_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="31" mass="3676" checksum="7B0AF179AA9F5580" modified="2009-09-22" version="1">MGMIVMLNLYTTQDKNPIYFGILFFNYAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X154</accession>
    <name>C6X154_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806452.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01724"/>
    <dbReference type="EnsemblBacteria" id="ACU08167">
        <property type="protein sequence ID" value="ACU08167"/>
        <property type="gene ID" value="FIC_01724"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01724"/>
    <dbReference type="HOGENOM" id="CLU_2301685_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="100" mass="12188" checksum="E5BCA8A54E436A4F" modified="2009-09-22" version="1">MIEQKLELFEFLDYITIKYKIVKKKFTSIDFDESALIKILMATYLDKFESKDALEFYDHPLSKREIDIVIENYDFTQINNEVLLEFQIPKQSRNWKQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X159</accession>
    <name>C6X159_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-likeFAD-dependent oxidoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806457.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01729"/>
    <dbReference type="EnsemblBacteria" id="ACU08172">
        <property type="protein sequence ID" value="ACU08172"/>
        <property type="gene ID" value="FIC_01729"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01729"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_17_0_10"/>
    <dbReference type="OMA" id="ERIYMMP"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="90"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="488" mass="53264" checksum="3CDDA2169738A965" modified="2009-09-22" version="1">MNETKNIKKQYSAWAVCPECQGLGKKKRRIRKSIRLHYLKELEAFEKTNPEGAPPVKPVAALYPCPDCNGSGVISAENFPTPDSEKYPHIAIIGGGIGGVALAVALKHRGIPFTLYERDQGFSERSQGYGLTLQQASKAIEGFGITSLDAGVVSTRHLVHTPDGKVVGEWGMRKWLENGTEKNPRRTNIHIARQSLRAALLGQLGGNEAVNWGHQLVGLTQSEDAGVELKFELNEKIIAAKADLVVGADGIRSVVRSLLINDEISPLRYLNCIVILGICPLNRLENTESDLLDSATVFQTANGHERIYVMPYDADSVMWQLSFPMSEDGAKELSAKGSSALKTEAIKRTQWHSPVPQILAATQEALVSGYPVYDRTLLGPEMLEKAGPVTLIGDAAHPMSPFKGQGANQALLDALHLAREIYSKCKTSGDWRATGTRANILETFETEMLARSASKVQDSAAAADFLHSETALYEGDEPRGRVLKRKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X176</accession>
    <name>C6X176_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01746"/>
    <dbReference type="EnsemblBacteria" id="ACU08189">
        <property type="protein sequence ID" value="ACU08189"/>
        <property type="gene ID" value="FIC_01746"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01746"/>
    <dbReference type="HOGENOM" id="CLU_3389558_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="32" mass="3709" checksum="5F1EAF1A3832FEDB" modified="2009-09-22" version="1">MRKKCAKFLELQAENDIKAHKTTLNHAKKITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X183</accession>
    <name>C6X183_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ordered locus">FIC_01753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806481.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01753"/>
    <dbReference type="EnsemblBacteria" id="ACU08196">
        <property type="protein sequence ID" value="ACU08196"/>
        <property type="gene ID" value="FIC_01753"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01753"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_0_10"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="OrthoDB" id="1701464at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="173" mass="18112" checksum="779ABD83B37FE326" modified="2009-09-22" version="1">MVGIIMGSQSDLKVMEQAADFLKTIGIAYELTVISAHRTPERMFGYAKSAKERGLKVIIAGAGGAAHLPGMVASCTTLPVIGVPILSSNSIDGWDSVLSILQMPSGIPVATVALNGAMNAGILAAKIIGSADENVAQKLQVFQDSLKEKVLGTVDEIRKSHPNAYDADLHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A1</accession>
    <name>C6X1A1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Thymidylate synthase</fullName>
            <shortName evidence="5">TS</shortName>
            <shortName evidence="5">TSase</shortName>
            <ecNumber evidence="1 5">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thyA</name>
        <name evidence="8" type="ordered locus">FIC_01771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01771"/>
    <dbReference type="EnsemblBacteria" id="ACU08214">
        <property type="protein sequence ID" value="ACU08214"/>
        <property type="gene ID" value="FIC_01771"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01771"/>
    <dbReference type="eggNOG" id="COG0207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_10"/>
    <dbReference type="OMA" id="KQYLDLC"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="7">
        <location>
            <begin position="40"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="302" mass="34477" checksum="CECF27A0F76B80B7" modified="2009-09-22" version="1">MVRCKRSKIFIRFVVLKISEKIFYPSNSKIKSKNSPVSMQNYLDLLQNIIDNGTNKTDRTGTGTRSIFGYQLRYDLSKGFPLVTTKKVHLKSIIYELLWFLKGDTNIKYLADNGVSIWNEWADENGDLGPVYGVQWRSWNGADGKVVDQISDVIDQIKKNPDSRRLIVSAWNVSEIPNMALAPCHALFQFYVADGKLSLQLYQRSADVFLGVPFNIASYALLLMMVAQVCELEVGDYVHTFGDVHIYNNHFEQVNKQLSRTPKPLPVMKLNPEIKDIFSFNFEDFTLENYDPYPGIKAPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C2</accession>
    <name>C6X1C2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01792"/>
    <dbReference type="EnsemblBacteria" id="ACU08235">
        <property type="protein sequence ID" value="ACU08235"/>
        <property type="gene ID" value="FIC_01792"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01792"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105789_2_0_10"/>
    <dbReference type="OMA" id="DKDTWLQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="180" mass="21039" checksum="370EB78A662F1CF3" modified="2009-09-22" version="1">MPVFFIILSMTEFQKYIQRYQDLVPSENWIEEMKISGERTSSLYKFLSEEQENFAYAAGKWTLKEVLQHLIDAEKIFAYRALRFAREDKTPLPGWDEEDYGKTYSLENRNIESLVEEFETIRKSSVIFFGNLDQIQLSHTGIANGNEISVEHLGKLTVGHNIHHLNVIDERYMTTITPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G0</accession>
    <name>C6X1G0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="4" type="ordered locus">FIC_01830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806558.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01830"/>
    <dbReference type="EnsemblBacteria" id="ACU08273">
        <property type="protein sequence ID" value="ACU08273"/>
        <property type="gene ID" value="FIC_01830"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01830"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_4_1_10"/>
    <dbReference type="OMA" id="KFYFHEV"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="180" mass="20712" checksum="A94DC2D0862AB482" modified="2009-09-22" version="1">MKKEDCYFLGKITRRHGLHGNVFLKLDTDQPEMYSKLDSIFVDINGMLVPFFVAKQSWSKGETLIISFKNSSEALVDQTLGKDVYLPLSTLPVLTGNKFYYHEVVGFEIREEDGKSCGIIESVNDQTGQHYFLLNLADKQVVIPIIREWILELNREEKYLKMSLPEGLMDVFLIPSKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H5</accession>
    <name>C6X1H5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TM2 domain containing protein+B7201</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806573.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01845"/>
    <dbReference type="EnsemblBacteria" id="ACU08288">
        <property type="protein sequence ID" value="ACU08288"/>
        <property type="gene ID" value="FIC_01845"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01845"/>
    <dbReference type="eggNOG" id="COG2314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081297_8_0_10"/>
    <dbReference type="OMA" id="EFYNTYQ"/>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="10767" checksum="B20A6F514C94E443" modified="2009-09-22" version="1">METYGYNNPGSQQNPQFNSYRSEKKLAAGLLGILLGAFGANKFFLGYINEGIIQIVLNIVTCGIATIIPLIEGIIYLTMSDEHFDRTYVQNKKAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I4</accession>
    <name>C6X1I4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BatB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806582.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01854"/>
    <dbReference type="EnsemblBacteria" id="ACU08297">
        <property type="protein sequence ID" value="ACU08297"/>
        <property type="gene ID" value="FIC_01854"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01854"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024570_1_0_10"/>
    <dbReference type="OMA" id="QFQWFLG"/>
    <dbReference type="OrthoDB" id="743737at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="91"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="335" mass="37247" checksum="0D4AB22E1C6B4D49" modified="2009-09-22" version="1">MNWYPGNNWYLLLLLLLPLLGYLMVNFARWKKKKKEIFADKRFRDELFDSRSRFSRFFPFLYLMASLFLIISIVDVLSGSEEVETKQKMNNVIFLLDVSNSMNAQDVEQNRLQQAKNLIINAMGKMTNDKVGIIVFAGEASSIMPLTTDFTAVETYVGGVETSIVKMQGTDFLKAMQTAADKFRNVAKGSRKVVLLSDGEDNEGNEKAAAKLANREGIRVISVGIGSEEGAPIPEYVFGQLMGYKTDLSGQTVISKRQTAALSNIADNTGGTYVDGNDLESATMQITDGLAATAGSSSTTIKSQNAVHYYQYFLAVAIFLFLIIFLFNPRKDFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I8</accession>
    <name>C6X1I8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806586.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01858"/>
    <dbReference type="EnsemblBacteria" id="ACU08301">
        <property type="protein sequence ID" value="ACU08301"/>
        <property type="gene ID" value="FIC_01858"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01858"/>
    <dbReference type="eggNOG" id="ENOG5033NZ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2828472_0_0_10"/>
    <dbReference type="OMA" id="WHEENSK"/>
    <dbReference type="OrthoDB" id="2039505at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="64" mass="7514" checksum="C3EE462974725480" modified="2009-09-22" version="1">MQLYYKIFLALFVIFIGFNLYSMEWQLGFWHEENSKFILSLSAAVIGIIVVFVLHMLSRLAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J7</accession>
    <name>C6X1J7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="12" type="ordered locus">FIC_01867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806595.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01867"/>
    <dbReference type="EnsemblBacteria" id="ACU08310">
        <property type="protein sequence ID" value="ACU08310"/>
        <property type="gene ID" value="FIC_01867"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01867"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_3_2_10"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="OrthoDB" id="1260295at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24095" checksum="6891A9A8DEEF0ABA" modified="2009-09-22" version="1">MSWTEILAPIKNTAYFEALWRKVKNEYASSECFPPQNQIFRALELTPFENVKVVILGQDPYHNDFQANGLCFSVSEKVAAPPSLKNIFTELKNDLGIDRTKKELDDWAEQGVLLLNATLTVKAHAPNSHKNLGWEQFTDFIIKEVSDRKENVVFVLWGAFAHKKAPLIDGAKHLVIKSVHPSPLSVYRGFYGSKPFSQINDYLAASGQEIISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U3</accession>
    <name>C6X1U3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08406">
        <property type="protein sequence ID" value="ACU08406"/>
        <property type="gene ID" value="FIC_01964"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01964"/>
    <dbReference type="HOGENOM" id="CLU_3396633_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="31" mass="3604" checksum="ACFF5BA345FAAF1E" modified="2009-09-22" version="1">MVKLCDLESEKKVMNSKVKNFIDEACWKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W3</accession>
    <name>C6X1W3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ordered locus">FIC_01984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806711.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01984"/>
    <dbReference type="EnsemblBacteria" id="ACU08426">
        <property type="protein sequence ID" value="ACU08426"/>
        <property type="gene ID" value="FIC_01984"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01984"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_10"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="144"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="531"/>
            <end position="534"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="584" mass="66919" checksum="F72E83916D3E40FA" modified="2009-09-22" version="1">MFRTHTNGELSLTNINENVTLSGWVQTIRDKGFMIWIDLRDRYGITQLVFDQDRSSVELLENAKKLGREFVIQVEGKVIERTSKNPKIPTGGIEILVEKLTVLNESQLPPFTIEDETDGGEELRMKYRYLDIRRNPVKDKLIFRHKMAQKVRNYLSDQNFIEVETPVLIKSTPEGARDFVVPSRMNPGQFYALPQSPQTFKQLLMIGGMDRYFQIVKCFRDEDLRADRQPEFTQIDCEMAFVEQEDVLEIFEGMTATLLKDITSKEFGKFPRMTFADAMQKYGNDKPDIRFGMEFVEVNELVQGKDFKIFDEAELVVGINVEGCADYTRKQIDELIDWVKRPQIGASGMIWVKYQNDGVVTSSVNKFYSEENLKKITEKFGAKEGDLILLMSGNENKVRTQLSALRMELGNRLGLRNSKEFAPLWVIDFPLLEWDEETGRYHAMHHPFTSPKPEDVHLLESDPGKARANAYDLVLNGNEIGGGSVRIFDKDLQSKMFDLLGFTKEDAEAQFGFLMNAFKYGAPPHAGLAFGFDRLVAILDGNEVIRDYIAFPKNNSGRDVMIDAPSYIANEQLDELYLKVETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y3</accession>
    <name>C6X1Y3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="11" type="ordered locus">FIC_02004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806730.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02004"/>
    <dbReference type="EnsemblBacteria" id="ACU08446">
        <property type="protein sequence ID" value="ACU08446"/>
        <property type="gene ID" value="FIC_02004"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02004"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_10"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="173" mass="18014" checksum="0511B27BAD58CE82" modified="2009-09-22" version="1">MLGLDNIEKVKPGGLELKDRLVSVNRVTKVTKGGRAFGFSAIVVVGDEAGTVGFGLGKSKEVASAIAKAVEDAKKNLVKVPVINHTIPHQSSARYGGADIFLRPASHGTGLIAGGAVRAVLESAGVHDILSKSKGSSNPHNVVKATFKALLDIRRPEDIAKLRGVSLSKVFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y7</accession>
    <name>C6X1Y7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="5" type="ordered locus">FIC_02008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806734.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02008"/>
    <dbReference type="EnsemblBacteria" id="ACU08450">
        <property type="protein sequence ID" value="ACU08450"/>
        <property type="gene ID" value="FIC_02008"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02008"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_0_0_10"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="89" mass="10152" checksum="8A01F719A211D0BC" modified="2009-09-22" version="1">MAKESMKARERKREATVAKYAEKRKALKEAGDYAALQLLPKDASPVRLHNRCKLTGRPRGYMRTFGLSRVMFREMANQGLIPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X229</accession>
    <name>C6X229_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_02050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806776.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02050"/>
    <dbReference type="EnsemblBacteria" id="ACU08492">
        <property type="protein sequence ID" value="ACU08492"/>
        <property type="gene ID" value="FIC_02050"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02050"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_0_2_10"/>
    <dbReference type="OMA" id="EMHPQAR"/>
    <dbReference type="OrthoDB" id="1425269at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="318" mass="35987" checksum="D33A116064EC17F8" modified="2009-09-22" version="1">MKITEHIKNANGKTLFSLEVVPPQKGSGIEDLYRNIDPLMEFKPPFIDVTTSREEYIYIDKGNGLMERKITRMRPGTLGICSAIQHKYDVDTVPHVLCGGFSQEETEYLLVDCMYLGIENVMALRGDAMKGQQYFEPTVGGHKNAMDLVRQMNDLGRGKYLHEDKTCDENNKFCIGVAGYPEKHIEAPSMNYDLKWLKQKVDAGADYVVTQMFFDNTKFIEFVKEARAIGINVPIIPGIKPVAAKSHLQMLPKVFKIDLPEALISEVEKAKDNAAVKQIGIEWTISQCRELLDFGVPVLHFYSMGKSDNIKQIARELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X260</accession>
    <name>C6X260_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806807.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02086"/>
    <dbReference type="EnsemblBacteria" id="ACU08523">
        <property type="protein sequence ID" value="ACU08523"/>
        <property type="gene ID" value="FIC_02086"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02086"/>
    <dbReference type="eggNOG" id="ENOG5032RMQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137778_1_0_10"/>
    <dbReference type="OMA" id="LPFYIWY"/>
    <dbReference type="OrthoDB" id="1866893at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="109" mass="13352" checksum="319388E8EA0D9CAA" modified="2009-09-22" version="1">MIIVLHALLKNTKISAITLFPLIILRTRALRSDSELITHEKIHLRQQLELLIVFFYIWYVVEYYYHFFRLKNPYKAYKAISFEREAYAMEHDPNYLATRKLWSFWNYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F4</accession>
    <name>C6X2F4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 4">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806901.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02181"/>
    <dbReference type="EnsemblBacteria" id="ACU08617">
        <property type="protein sequence ID" value="ACU08617"/>
        <property type="gene ID" value="FIC_02181"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02181"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_5_1_10"/>
    <dbReference type="OMA" id="RDNQLPW"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="18882" checksum="4526EC128DBED6B3" modified="2009-09-22" version="1">MITIVVAMGLKNEIGADNQLLWHLPQDLKHFKEITTGHPIIMGRKTYESIGRPLPNRTNIVVSRKKDWFAEGVLIVGSLKEALKFAKKIDENVFVIGGGNIYEQTIDLADKLEVTLVKAEINADIFFPKIDLKIWEKTSETCIDKDEKHAYDFCFQTFVKKVGSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J1</accession>
    <name>C6X2J1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02219"/>
    <dbReference type="EnsemblBacteria" id="ACU08654">
        <property type="protein sequence ID" value="ACU08654"/>
        <property type="gene ID" value="FIC_02219"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02219"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_10"/>
    <dbReference type="OMA" id="SCDMVVC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="266" mass="29426" checksum="3FF2A6D988CF55FB" modified="2009-09-22" version="1">MIYTQLEIDSHLDGKLQIAYLNQPDTFNSLNKGLLTELRTFVKECSKNSVVRCIAISGRGKAFCSGQNLKEALAMGDTKDERIIQRMVIDYYNPLVKEIATCRKPVVSMVNGPAVGAGAMLALICDITLATESSYFSQAFVNIGLIPDTGGTYWLPKIMSRQQANYLAFTGKKIPASEAKSMGFIADVFKDETFETECMEVLTMLSNLPTKAIGLTKKAFNESYSNTLKEQLDVESILQQEAAETSDFMEGVTAFLEKRKPSYQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J3</accession>
    <name>C6X2J3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02221"/>
    <dbReference type="EnsemblBacteria" id="ACU08656">
        <property type="protein sequence ID" value="ACU08656"/>
        <property type="gene ID" value="FIC_02221"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02221"/>
    <dbReference type="HOGENOM" id="CLU_3135934_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="49" mass="5617" checksum="6206EF4C29B3A9FF" modified="2009-09-22" version="1">MELIKNFVMKKLMSVIIMNEITMETSAGSIFGFIFSFLNYIFLSSGLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L7</accession>
    <name>C6X2L7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ordered locus">FIC_02247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806964.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02247"/>
    <dbReference type="EnsemblBacteria" id="ACU08680">
        <property type="protein sequence ID" value="ACU08680"/>
        <property type="gene ID" value="FIC_02247"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02247"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_3_3_10"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="194" mass="22529" checksum="F08B471028D662F8" modified="2009-09-22" version="1">MKKIGLFFGSFNPIHIGHLILANYILENSDMDELWFVVSPQNPFKDKKSLLNDHNRLDMVQLAITNYPKMRASNVEFSLPNPSYTIDTLVYLKEKYPDHSFSLIMGEDNLESLSKWKNSETLIKNHQIIVYPRTFSDEKPHHEYPVHSNIALINAPMIEISATEIRKMIKEGKNVRPMLPPEVFEYLDGSAFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M5</accession>
    <name>C6X2M5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen-fixing NifU, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806972.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02255"/>
    <dbReference type="EnsemblBacteria" id="ACU08688">
        <property type="protein sequence ID" value="ACU08688"/>
        <property type="gene ID" value="FIC_02255"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02255"/>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_4_3_10"/>
    <dbReference type="OMA" id="CSVNQMT"/>
    <dbReference type="OrthoDB" id="2010888at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="77" mass="8694" checksum="ADDBBB8FC5E65BC8" modified="2009-09-22" version="1">MHEQTVSKVMYALEKIRPFLNKDGGDIELVDVRESIVYVKLQGNCNGCPMSFSTMKLGVENTIKQHAPEIQEVINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N9</accession>
    <name>C6X2N9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806986.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02269"/>
    <dbReference type="EnsemblBacteria" id="ACU08702">
        <property type="protein sequence ID" value="ACU08702"/>
        <property type="gene ID" value="FIC_02269"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02269"/>
    <dbReference type="eggNOG" id="ENOG5032T6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376373_0_0_10"/>
    <dbReference type="OrthoDB" id="1724351at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="197" mass="23325" checksum="213F8C99C7845A7E" modified="2009-09-22" version="1">MEEFKELESLWKQSETKVPQHNTNISKIKNNRMKLKKIYTFGALLLILTGIFILTLMAFLDERLQTGLVMASMILISLVCFLQAGLMMFTARKITRIDESQTPALHLNQWLQFREFQKKQRHWNMPVYYVILSIAVGVYMYELLKATEVWKMALAFGITYLWMFFAYFYLGKKEVKKQDAKLEGIISELRDLEIQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q7</accession>
    <name>C6X2Q7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formimidoylglutamase</fullName>
            <ecNumber evidence="3">3.5.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formiminoglutamase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Formiminoglutamate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hutG</name>
        <name evidence="5" type="ordered locus">FIC_02287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:22492"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="EC" id="3.5.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.8" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807004.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02287"/>
    <dbReference type="EnsemblBacteria" id="ACU08720">
        <property type="protein sequence ID" value="ACU08720"/>
        <property type="gene ID" value="FIC_02287"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02287"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_2_0_10"/>
    <dbReference type="OMA" id="GTMFRQI"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050415">
        <property type="term" value="F:formimidoylglutamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00737">
        <property type="entry name" value="Formimidoylglutam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005923">
        <property type="entry name" value="HutG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01227">
        <property type="entry name" value="hutG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="306" mass="34018" checksum="DA5562CEC56E252E" modified="2009-09-22" version="1">MIWTGRFDGDDPLYHRIFQRVTQERNYDNISPNDFVLHGFAVDEGVKRNSGRVGAKDAPDVIRKSMANFPVINPEFTLKDFGNIFCDDGDLEASQNSLSEKVAQVLQKQGKSIVLGGGHEVMFAHYSGIRKAFPAQKIGIINIDAHFDNREVNSQTGPSSGTGFSQIAQQEELHSLHIGIQKNSNTLKLFDMAHQFGMKYILADELFFENLPALYQKTDDFIAEVDILYLTVCMDVFNASVAPGVSATSYNGIFADAAFMHLFRHLLQSQKLLAMDVAEVNPSLDQADITARLAASLINEWLTVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T0</accession>
    <name>C6X2T0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807027.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02310"/>
    <dbReference type="EnsemblBacteria" id="ACU08743">
        <property type="protein sequence ID" value="ACU08743"/>
        <property type="gene ID" value="FIC_02310"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02310"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028261_0_0_10"/>
    <dbReference type="OMA" id="YATRGFD"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="170"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="252"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="640" mass="70343" checksum="2999D09F916ECCB8" modified="2009-09-22" version="1">MIRNIFVISGLIAFSALNAQKIHTVVKGDNPYNISKKYGLSIDDLYRLNPKVQDGKIAIGEVLVVNKSTVSAQTSGPKTSASASKTQAEIGKIVLQPKQTVYGITKQYRISETDLRALNPNLDAHMKIGDEVWLPAESIAKYGAGQVNVAENNPASTSVVSAVEVNGTSDRYQIQEKDNYYKLTRKFNVTQKELFALNPGLEDKGLQPGETILIKGAANGTGGTKAGSKATQVVDTMPPNTYSTTSVSDDYVTYTVQSGDTVFGILNKFGITLDQLLTLNPNLSAGLKSGMVLKIKKLDEGYVKKSGDALNVVIMLPFGFDTNDSKFRTLSLDFLAGAKLAIERNVAKGQQLDVKIIDAGNEASFKNSLTQINAGNTDLIIGPFFKSSVLQVLDYVKSNKIPVVAPFANSDDLLKHENLILVETNKLVFADRIVKEVKDVYSDQKIYIVADEDRSNANYLKTNLEKAIKNATVVIVNSPADIKLDQNMMTGQSAPVIAILASENDSDGDAFANRMITLSKDVQNIKAFSMYYSPIFERKVDELSQANLVYLMDRKIDTDGNFEKEILAAYKAKYCKTPPKYSVIGFDIVNDMLSRENKKGEIFKQINKVQTQLATKFEFEKTKNGAYVNKGYRVVRLLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U0</accession>
    <name>C6X2U0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="9" type="ordered locus">FIC_02320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807037.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02320"/>
    <dbReference type="EnsemblBacteria" id="ACU08753">
        <property type="protein sequence ID" value="ACU08753"/>
        <property type="gene ID" value="FIC_02320"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02320"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_10"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NusA_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="KH_5" evidence="8">
        <location>
            <begin position="233"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="415" mass="47242" checksum="50B6070E67263680" modified="2009-09-22" version="1">MDGLALIEAFGDFKEEKSISKIDLMAIIEDSLKTLLRKRFDSDDHFDVIVNPDKGDFQIFLNKTIVEDDMSEDDDLEIEISEAKKIDPTFEVGEEFTIEIPIEGLGRRSILTLKQILATKLQEHNNAVLYEEFRDKIGEIVVGEVHHIRHKHVILLDDEDNEFILPKENQIPSDFFKKGENIRTIVESVDFKGSKPQIIVSRTAPKFLEKLLELEIPEIQDGTIILKKVVRIPGEKAKIAVDAYDDRIDPVGACVGVKGSRIHGVVRELKNENIDVIQWSKNPEIMVKRALGNVTVNKIEINEETKYAMVYTPVEEISRVIGKQGQNIRLASWLSGYEIDVHRESAEDDDVELKEFAGSDAGDIEQWIIDEFNKVGLTTAKSVLDKDTEALLKMVDLEEETIEEVKQILKEEFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U7</accession>
    <name>C6X2U7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807044.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02327"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08760">
        <property type="protein sequence ID" value="ACU08760"/>
        <property type="gene ID" value="FIC_02327"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02327"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_4_10"/>
    <dbReference type="OMA" id="GLAGNWN"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="292" mass="34276" checksum="A1DFB143A818730F" modified="2009-09-22" version="1">MLQKLKTMENTLVSICIPTYNGEKFIQEALDSVRNQTYKNIEVIISDDASKDSTMAICEQFKEKAPFPVHIYSHQPEGIGANWDHCIQRANGEFIKFLFQDDILEPNCVEEFVKLQHQTGENVFYCKRKLIDEDGADISETTYIADLQTPINLTFDDFYLFTKKDLKKLASKYSTALSHNFFGEPVACFASKKAYVSTGKHNSDLKQLVDFEYSLRLLEHYPVVITAQKLIRFRVHKQQTTYRNQLSDVKENDIINDYLIKKYFRYLDRRVIMRYYYNKYPLLSKLRGKIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W5</accession>
    <name>C6X2W5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807062.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02345"/>
    <dbReference type="EnsemblBacteria" id="ACU08778">
        <property type="protein sequence ID" value="ACU08778"/>
        <property type="gene ID" value="FIC_02345"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02345"/>
    <dbReference type="HOGENOM" id="CLU_945786_0_0_10"/>
    <dbReference type="OrthoDB" id="1590899at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972250" evidence="1">
        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="294" mass="31685" checksum="B8C17D1661D72091" modified="2009-09-22" version="1">MKKLLYIFPALIGLMLMVSCQPGRDESGDLLFGLDPNLPGSGGGSGGSGTTKYLHKLTFPDGMGGNYTVTYNYALGKLTNVRSSDNSVSYDLTYDNNNISKIKVVQDDGGTITTTNFDISYTNGKFTEAKGTGVEDSGNLFNNTITASYAAGKVSKIVSKMQGIDISDPTVTFDMFTMQNDITYSGNNISVWKSTMSMPPMPPITLPPIVITANFSDYDAYKNPFNTLPEVFNIVSSVFGTDTSAVTAFSANNYKKVSVEGQTVTYTYTYDADGYPTKAVASEDAGTLTFEYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X8</accession>
    <name>C6X2X8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="7" type="ordered locus">FIC_02358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807075.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02358"/>
    <dbReference type="EnsemblBacteria" id="ACU08791">
        <property type="protein sequence ID" value="ACU08791"/>
        <property type="gene ID" value="FIC_02358"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02358"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_6_2_10"/>
    <dbReference type="OMA" id="MQEIEIF"/>
    <dbReference type="OrthoDB" id="1953872at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="160" mass="18211" checksum="88CB13345A8AC7E1" modified="2009-09-22" version="1">MSLRIEIYTDGACSGNPGKGGYGIVMKVPEKNYEKHFSKGFRLTTNNRMELLAVIVALEKLKSPDNDIHIYTDSKYVSDAINKKWLLGWIKKGYKNVKNPDLWRRMVPLLATHKTTFHWIKGHAGHPENEICDQLAVKAAQSGKLETDQYFEDQKNGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y2</accession>
    <name>C6X2Y2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_02362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807079.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02362"/>
    <dbReference type="EnsemblBacteria" id="ACU08795">
        <property type="protein sequence ID" value="ACU08795"/>
        <property type="gene ID" value="FIC_02362"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02362"/>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_0_2_10"/>
    <dbReference type="OMA" id="DMIMLKD"/>
    <dbReference type="OrthoDB" id="1718114at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="115"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="286" mass="31648" checksum="B4F5E441777733DC" modified="2009-09-22" version="1">MKRPSYVTDKALKQFIKNALAEDIQEGDHSTLATIPKDLEQKAKLLVKEDCILAGAEMAEMIFNHFDKDLKMEVLIKDGQSAKVGDIAFYVTGSARSILSTERLVLNCMQRMSGIATLTHDWDSRLLGTKTKLLDTRKTTPNFRICEKWAVAIGGGTNHRFGLYDMMMLKDNHIDYNGSIANAVKMAKEYSKDNKKKLKIEVETRNLDEVEQALKAGVDRIMLDNMDVPTMQKAVELIGGRCESEASGGITRDMLKSIAQTGVDYISAGALTHSAANIDLSLKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y5</accession>
    <name>C6X2Y5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal protein L27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807082.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02365"/>
    <dbReference type="EnsemblBacteria" id="ACU08798">
        <property type="protein sequence ID" value="ACU08798"/>
        <property type="gene ID" value="FIC_02365"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02365"/>
    <dbReference type="eggNOG" id="ENOG5031XJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134903_0_0_10"/>
    <dbReference type="OMA" id="FTMIFFH"/>
    <dbReference type="OrthoDB" id="1927917at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="145" mass="16429" checksum="0F203A20DCB56EE1" modified="2009-09-22" version="1">MDYNIMLQAHRGFAYLILLAIAVFVVALVMTMFGYSGKITKLLRKSTLFTMIFFHTQALIGLIMLFFFSPGFKAATEAGILMKDSVARNTYVEHPFAMIVSAVLLTILNKKFKTNDKIQMSWVIMAVIALALMLWAFQWSRLFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X326</accession>
    <name>C6X326_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neutral zinc metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807123.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02406"/>
    <dbReference type="EnsemblBacteria" id="ACU08839">
        <property type="protein sequence ID" value="ACU08839"/>
        <property type="gene ID" value="FIC_02406"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02406"/>
    <dbReference type="eggNOG" id="COG2321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059329_0_0_10"/>
    <dbReference type="OMA" id="QKRSQGY"/>
    <dbReference type="OrthoDB" id="1175086at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="284" mass="31181" checksum="8FDBA5FA1E8BA783" modified="2009-09-22" version="1">MKWTNDRSGNVDDRRGSGGGGGMLVGGGLGSLIIAAIIFFLGGDPSAILSGSGATTQQTEQRDLTAEELQVREFVQMITVENEQSWDKIFQENGMQYQPAKVVMFEGVTQSGCGTAQAAMGPFYCPADQTVYMDMSFFAELQQRFGATVTEFSVAYVMAHEMGHHVQNLLGTLQKTEQLRASGRYSESDMNKVSVATELQADFYAGLWARYTDSREKFLEPGDLEAAISAAEAVGDDNIQKRSQGYVNQEAFTHGSSAQRKEWFMKGYNTGDIRQGDTFNTLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X364</accession>
    <name>C6X364_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="6" type="ordered locus">FIC_02444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807161.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02444"/>
    <dbReference type="EnsemblBacteria" id="ACU08877">
        <property type="protein sequence ID" value="ACU08877"/>
        <property type="gene ID" value="FIC_02444"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02444"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_10"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="85" mass="9179" checksum="33DF6668B3319F89" modified="2009-09-22" version="1">MAHKKGVGSSKNGRESHSKRLGVKIFGGQAAIAGNIIVRQRGTQHHPGENVGMGKDHTLHALVDGKVVFRKKQNDRSFVSIEPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X371</accession>
    <name>C6X371_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetracycline resistance protein TetQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807168.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02451"/>
    <dbReference type="EnsemblBacteria" id="ACU08884">
        <property type="protein sequence ID" value="ACU08884"/>
        <property type="gene ID" value="FIC_02451"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02451"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_10"/>
    <dbReference type="OMA" id="DRGHEDH"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="6"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="707" mass="78736" checksum="AFF50338D8AC3FD3" modified="2009-09-22" version="1">MSANTKDLRNVVLLGHSDSGKTTLIETMLYEGGAIKRRGSVEGQNTVSDHTDLEHEKGKTIFSHQMFVNWKNNKINIIDTPGFDDFVGEVVSSLKVADTAVIVLNAANGVEVGTELVWEYVEKYQTPAIFVINQMDHPKADFERTLEQAKERFGSKLVPLQYPYNSGSNFNAIIDALRMVMYEFPLNGGKPEKKPIPETEMVRANEMHNALVEIAAENEEGLMEKYFEEGNLSEDDLAKGITIALAKQQFFPVFVTSGLKDMGSGRLMGFIDDIAPSPAERPARKLENGDEISYDPNDKTTIFIYKTLSEPQVGMVSYFKVLSGKLKPGDELVNANNGETERISQLFVAEGKDRIPVDELVAGDLGVTVKLKFGHSNNTLNSKGLDRKVRPMEFPESRIRKAVSADSTAAMEKLVTALHKIEEEDPTLKVEQSAELKQTILHGQGQLHLDLVKQRLQKDFGVKMNFDNPKIPYRETITGNADADYRHKKQSGGSGQFGEIHMRVENYYDDMPEPTGVNIRQKDIEELPWGGKLAFYWCIVGGAIDNRYIGAIKKGIMQQMKEGPLTGSHCQNVRVTVYDGKMHSVDSNDISFQLAASGAFREGFQAAKPQLLEPVYSVEILCPDEDTGDVMGDLQTRRAMISGMDSEGHYQKILAEVPLAELHDYGSTLRSITGGRAKFTMKFSEYQLVPPNVQQELVKSHAHLQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A0</accession>
    <name>C6X3A0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807197.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02480"/>
    <dbReference type="EnsemblBacteria" id="ACU08913">
        <property type="protein sequence ID" value="ACU08913"/>
        <property type="gene ID" value="FIC_02480"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02480"/>
    <dbReference type="HOGENOM" id="CLU_2859588_0_0_10"/>
    <dbReference type="OMA" id="HTAYEEY"/>
    <dbReference type="OrthoDB" id="2099280at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="63" mass="7189" checksum="3E4E85A337CD2B1E" modified="2009-09-22" version="1">MKRDTGILLAGSLGVIVGLGLYGLKWFTSKKHTAYEEYYADHHRNYDNRYGDDHDGVEILAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A4</accession>
    <name>C6X3A4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AP endonuclease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807201.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02484"/>
    <dbReference type="EnsemblBacteria" id="ACU08917">
        <property type="protein sequence ID" value="ACU08917"/>
        <property type="gene ID" value="FIC_02484"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02484"/>
    <dbReference type="eggNOG" id="COG3021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060500_0_0_10"/>
    <dbReference type="OMA" id="CGDMNNS"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="224"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="325" mass="37105" checksum="6FE9599C20B2B68E" modified="2009-09-22" version="1">MKIIRFLLTAAHLVILALLLGTLLNSGIAPKTFPWINVLSLTFAPLMILNVCLIILWVIMWKKRALFFLAVSLLLINPTRRWLNFTGESNEKANLKIVTMNIKGGGYGREAIYEYLNTSGADVVLAQEHMGELSVPGYSHRTDTYELTALNSKTEILHQEKIKTSENGEAFFADIRINGKTIRFVNIYLNPFSFDKSKVKPSEDYDKNKRKLRYILSTLIPTFKAHQDEVSVIKKTIAESPYPVIVAGDFNAVPNSYEYYQLSENLKDVFVETGNGNSTSFHDYKIPIRIDYVFCSEEITPVRYTVDRRAKMSDHYPIIAEFKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M0</accession>
    <name>C6X3M0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782155.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00550"/>
    <dbReference type="EnsemblBacteria" id="ACU07008">
        <property type="protein sequence ID" value="ACU07008"/>
        <property type="gene ID" value="FIC_00550"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00550"/>
    <dbReference type="eggNOG" id="COG2354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059391_0_0_10"/>
    <dbReference type="OMA" id="LWAITKG"/>
    <dbReference type="OrthoDB" id="1419056at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008526">
        <property type="entry name" value="YedI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30503">
        <property type="entry name" value="PTHR30503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05661">
        <property type="entry name" value="DUF808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016660">
        <property type="entry name" value="YedI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="302" mass="32690" checksum="3952D2C4A9048345" modified="2009-09-22" version="1">MASGFFAILDDIAALMDDVAVTAKLATQKTAGILGDDLAVNAEKATGFLESREIPVLMKIMKGSFINKLIIVPVVFLLQWLYEPAITIILIFGGFYLAYEGIEKIIEFIFHRQKKGHEVIQEAEQTTTNGEELEKSKIKSAVTTDFILSLEIVIIALASAKAGYEALKSQFDPLLVEIVTVSIVAIIATVGVYGIVALIVRMDDAGYKIIKRSKTESGFLVSAGTFLVNALPWVIKGLGVVGTIALILVAGGIFVHNIEWIHHHFLPNANSLLRESLAGIIGGLIAIPVFKLGIKALSIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M1</accession>
    <name>C6X3M1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00551"/>
    <dbReference type="EnsemblBacteria" id="ACU07009">
        <property type="protein sequence ID" value="ACU07009"/>
        <property type="gene ID" value="FIC_00551"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00551"/>
    <dbReference type="HOGENOM" id="CLU_3135930_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="49" mass="6011" checksum="F09D5F6B3A96B648" modified="2009-09-22" version="1">MQHHCLKSLFCEIKIFKPNLKTVDPEFFYYLKTDLNVFEVKYLFLPLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q4</accession>
    <name>C6X3Q4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="13" type="ordered locus">FIC_00587</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00587"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07042">
        <property type="protein sequence ID" value="ACU07042"/>
        <property type="gene ID" value="FIC_00587"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00587"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_10"/>
    <dbReference type="OMA" id="FGMKWMM"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="156"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="634"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="671" mass="77674" checksum="8290175F071C8FAE" modified="2009-09-22" version="1">MENVISHSLFTDHDIYLFREGSHYKLYDKFGAHTIEVSGIAGVYFAVWAPNANEVSVIGTFNGWHSESHKLFPRWDGSGIWEGFIPDLKWGDLYKYAIRTNKDVLLEKGDPFALSWEQNVQAGSVISTTWFEWTDQNWMAERWKNNSFEAPISVYEMHLGSWMRGTDDPDKFFSYREIAARLVPYLKEMNFTHVEFMPVMEYPYDPSWGYQVTGFFAGTSRFGSPQDLMFLISELHQNGIGVILDWVPSHFPGDANGLHFFDGTFLYEHEDPRKGFHPDWKSYIFNYGRPEVKSFLISNAMFWLDRYHADGLRVDAVTSMLHLDYSRNEGEWEPNVEGGNVNLEAKKFLQDFNKAVYKEFPDIITIAEESSDFPMLTKPVHDGGIGFGMKWMMGWMHDTLKYFKTDPLGRKFEHNKLTFASMYMYNENYMMPLSHDEVVHGKASLIYKMPGDEWQKFANLRALYTYMYTHPGAKLLFMGCEFAQTREWNFTQSLDWHLLGYEVHKGMQSYVKDLNKIYSAEKSLHENQFKPEGFEWVEANDDNNSIYIYLRKGKTEDDVTMTVLNLTPRVFDYKIGINEGTRWDVILNSDERKYGGSGVDAEIVDEEDDEWMYRPNAVILRLPPLAGVVLRQQKSAEVEPLNKVSNKTSKKTAGNGKKAGAGKKTKTSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W0</accession>
    <name>C6X3W0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782244.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07098">
        <property type="protein sequence ID" value="ACU07098"/>
        <property type="gene ID" value="FIC_00643"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00643"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012344_3_1_10"/>
    <dbReference type="OMA" id="ANLGWSC"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973432" evidence="1">
        <location>
            <begin position="19"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="31"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="381"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="452" mass="48363" checksum="249CB28EBBF0A44E" modified="2009-09-22" version="1">MKNLLLSLALLGAGLFEAQNVSLAGFASGFTAPVEITNANDSRLFVVQQNGLIKIVQPDGSVNTANFLNISSKITFNGERGLLGLAFHPNYATNGYFYVFYNNTAGNITIARYTVGSTDPDVADIATEKILLNITKPFSNHNGGSIHFAPDGYLWISTGDGGSGGDPNNNGQNKNSLLGKMLRIDVNTTGTYTIPPGNPFIGVDGADEVWSYGMRNAWKFSFDTQAGNVMVADVGQGAIEEINRVPISTAGVNYGWRCYEGNSVYNSTGCAAASTMTFPVAVYNHSGGRCSITGGYVYRGNNYPAFEGKYIFADYCSTQIGIMDSANAITWSLPFNGKNFSTFGIDMNNELYVAAVNDGTLYKVITSSLATDDQASAKIQLYPNPASGTLYVKGLQSKNNSAEFINPEGRKVSEVAVNGDGSIDITRLNAGVYYVTIKSDGLKIYSQTVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X417</accession>
    <name>C6X417_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OstA-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782301.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00700"/>
    <dbReference type="EnsemblBacteria" id="ACU07155">
        <property type="protein sequence ID" value="ACU07155"/>
        <property type="gene ID" value="FIC_00700"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00700"/>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014976_0_0_10"/>
    <dbReference type="OMA" id="YCERGFY"/>
    <dbReference type="OrthoDB" id="1907171at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13100">
        <property type="entry name" value="OstA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973437" description="OstA-like_N domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="2">
        <location>
            <begin position="43"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="578" mass="65659" checksum="C85DB76CBADFF874" modified="2009-09-22" version="1">MKQLFVLFLLVCANVFGQINTRPNDPLVKDPFFNASQSAPPGQKVRLIHSDFFQKSLDRYNGNPFFSGNVQFEQQGSVLFADEVIFYEKENFVKAIGNVKLQNADGSVITAGEMEYDGNTQKGIAKKNVILTDPRQTIKTETLYYDRIANVAYFNTGGTISDATNVMYTRSATYDLTSRMIDFTGNVKINNPDYTVEGSNIKQNQNTNTADFFGPTTITNKQNPSNLIYTERGSYNMNSKEVYLKKNSRINYNGKILTGDDMYFNQITGFGTAKGNVTLRDPAENRYMKGGYGEIYEKKDSAMMTERPYAVKILEKDSMYFSAQRILAYQQTDAADPTKKKSFLRAFRKSRMYKSNIQVRADSLSFNETDGIMHLFGKPIAWSGEKQVTGDKIEAYFDTENEFIDSLKVVGNAFAISKADSLNLKDEFNQIKGKLMTVYYKDNKVNLAKVIGNAQAITYADDQNEKTKEVERIGVALSTCGTIEAEFEENKVQIISCNVGANTDVYPMSKISREKRFFPDFNWNTKDRLKRWEDIFLDSPGYEETQYESADTLYNQAQKAIDEAKAKEEAKKPKRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X431</accession>
    <name>C6X431_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782315.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00714"/>
    <dbReference type="EnsemblBacteria" id="ACU07169">
        <property type="protein sequence ID" value="ACU07169"/>
        <property type="gene ID" value="FIC_00714"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00714"/>
    <dbReference type="eggNOG" id="ENOG50334CE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2702460_0_0_10"/>
    <dbReference type="OMA" id="FATIFKF"/>
    <dbReference type="OrthoDB" id="2059221at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="75" mass="9080" checksum="334D148060039991" modified="2009-09-22" version="1">MKYILEIILTIIIVFFLWNILKRMFFATIFKFPKPNQPQGDVRQQKTRKNLDSKINWDAETVDYEEIKEADDKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X442</accession>
    <name>C6X442_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782326.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00725"/>
    <dbReference type="EnsemblBacteria" id="ACU07180">
        <property type="protein sequence ID" value="ACU07180"/>
        <property type="gene ID" value="FIC_00725"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00725"/>
    <dbReference type="eggNOG" id="COG2350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_5_2_10"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="88" mass="9771" checksum="FF435B18DB06CA26" modified="2009-09-22" version="1">MKAVVFYEHADAPMEKFMEVFPKHEIFEADFIKSGKVLGSGAFSNPGEGVMAIFVNKEAAEEFVKGDPFVLAGLVAKVTVREWDDELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X444</accession>
    <name>C6X444_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782328.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00727"/>
    <dbReference type="EnsemblBacteria" id="ACU07182">
        <property type="protein sequence ID" value="ACU07182"/>
        <property type="gene ID" value="FIC_00727"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00727"/>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_1_0_10"/>
    <dbReference type="OMA" id="VAWVGSE"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973440" description="Amidohydro_3 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro_3" evidence="2">
        <location>
            <begin position="70"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="540" mass="61191" checksum="BBF84817E63F9705" modified="2009-09-22" version="1">MKNIFRIFALLFSTVICAQKSADLIIHNAKIYTVNQKFTTAESMAISDGKIVAIGRSKDILKKYKSANIQNLDGKTVFPGFIDAHCHFTGYATDRWKCELWGTKSWEEIIQKMTVYAKTAPTEWLYGRSWDQNDWPVKEFPNKAKLDELFPDRPVYLKRVDGHAAIANQKALDIAGISLDTKVSGGTVEVQNGKLTGILIDNAMLLVEKHIPEISDEMAIQYFGELQKECFSYGLTSLHDCGISTHTFSLLEKAQDRELLKMKIFALLSDEPSTYNEWIKKGRFTNGNITFGGYKVYSDGALGSRGACLLHDYSDKKDWKGFLLSDQKYFENLAKKLKNSDLQMCTHAIGDSANRTILKIYGDVLGIKNERRWRIEHAQIVDKKDFEMFGKYSVIPSVQPTHATSDMYWAEERLGKERLQHSYAYQELLQQNGWLPLGTDFPVEEINPIKTFYAAVARKDAKDFPANGFQKENALTREQALRGMTIWAAKAAFQENEVGSLEAGKSADFVVLNQDLMEVAEDKILQTKVLETFSNGKKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X488</accession>
    <name>C6X488_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782372.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00773"/>
    <dbReference type="EnsemblBacteria" id="ACU07226">
        <property type="protein sequence ID" value="ACU07226"/>
        <property type="gene ID" value="FIC_00773"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00773"/>
    <dbReference type="eggNOG" id="ENOG502ZAAQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573359_0_0_10"/>
    <dbReference type="OMA" id="PQTEMIN"/>
    <dbReference type="OrthoDB" id="324379at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973681" evidence="1">
        <location>
            <begin position="24"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="476" mass="51958" checksum="98FFE617509FB26A" modified="2009-09-22" version="1">MKAIRGFIIVIFTICCGSTVTKAQDVYLSIPEDNIFNRSEFTSLPTTVMNTSRTNWDYAFFGLGPVSPTFTSTSGANFIQSSSSLTLPNTVLLWQLESMGGQMPSTGYLGYLPGFQSFSTGAVRWFEPPSSVLGGGFNRGNINFTFKIPAAQFAANAFQAGNYSMNITQNYDFTPRNFRTVLVIPASVRWLTASPTKYIEISSLNDYRITGTRVLGNLGNAEIGHTVDFNLWAKAAANNIQFVSSKGTQGTRNIATIKLGSNGSALTTKALSSTFQNFSASNFSVIPGNRNSFIPELYVSAEDLKTHFFEAGTYTFELNFSARSTDNSINSLQNTAVQLKVLPRSEITIPSSGQNVNFNFNTAAHYANGQSQTIQKQIKLSNNENFELYVKSDENYFKKGGVQTAINSNILQIGLEGSSANVPLSKIPQKILTNGTPVLDRELNVRYTIPPAGAQTLVGKESSTYSVNVYYSFTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X496</accession>
    <name>C6X496_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex</fullName>
            <ecNumber evidence="5 9">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_00781</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="9">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5 9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782380.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00781"/>
    <dbReference type="EnsemblBacteria" id="ACU07234">
        <property type="protein sequence ID" value="ACU07234"/>
        <property type="gene ID" value="FIC_00781"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00781"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_0_10"/>
    <dbReference type="OMA" id="MKVPSPG"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="418" mass="44939" checksum="9D620E7D3276806C" modified="2009-09-22" version="1">MSILEMKVPSPGESITEVEIASWLVKDGDFVEKDQPIAEVDSDKATLELPAEESGIITLKAEEGDVVQVGQVVCLIDRDGAKPEAAAPAEAPKTQNAEAPQAEQKVVEKPAIVQEKKEEKPATYAAGAPSPAARKILDEKGVDAAQVSGSGKDGRITKQDAETAGVPAMGSATGSGGSRAISTTKLSMLRRKLAVRLVSVKNETAMLTTFNEVDMSEIFRIRKQYKDEFSQKHGVGLGFMSFFTKAVTRALQMYPDVNASIDGDFKNNYEFCDISIAVSGPKGLMVPVLRNAENMSFRGVEANIKSLADKVREGNISIDEMTGGTFTITNGGVFGSMLSTPIINPPQSAILGMHNIIQRPVAVDGQVVIRPMMYVAMSYDHRVIDGRESVGFLVAVKEAIDNPKEFLMGGDERKALEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B0</accession>
    <name>C6X4B0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ordered locus">FIC_00795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782394.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00795"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="ACU07248">
        <property type="protein sequence ID" value="ACU07248"/>
        <property type="gene ID" value="FIC_00795"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00795"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_10"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="OrthoDB" id="267682at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="38"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="496" mass="55526" checksum="50F56628E359362A" modified="2009-09-22" version="1">MHDLQIQKDNYLNQFTERVYGRNLLKTDDVFDAPTEECGIFGIYSDVDLDTFSLSQFGLFALQHRGQEACGISVMKNGKIFNIKDEGLVLDVYKNIREPETFMGNSAIGHTRYTTAGDKKKYNFQPFFAKNEYDQIILSIAHNGNLTNAEELKRELEAEGVVFKATSDSEVILRLIQKNLDLGLRGAIKATMEKIEGAYSVVGMTRNKFFAFRDFHGIRPLVLGAIDEKTFVAASESVALDAVGAQYVRDILPGEIVYTSENETGLKSFLVRENCEKRICAFEYIYFARPDSILENINVYKIREKSGEKIWEQAPVEADVVIGVPDSGVPAAIGFSKASGIPFRPVLIKNRYIGRSFIVPTQDMRERIVNLKLNPIISEIRGKRVVIIDDSIVRGTTSKRLVKIMKDAGVKEIHFRSVSPPIIAPCYLGIDTPSKDDLISANMNANELRDYLGVDSLEFLSMDNLKVILGSSNHCFGCFTEQYPVPAGPSPDYTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4G4</accession>
    <name>C6X4G4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial leucyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782448.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00849"/>
    <dbReference type="EnsemblBacteria" id="ACU07302">
        <property type="protein sequence ID" value="ACU07302"/>
        <property type="gene ID" value="FIC_00849"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00849"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705464_0_0_10"/>
    <dbReference type="OMA" id="SDYMPFQ"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973572" evidence="1">
        <location>
            <begin position="19"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="92"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="384" mass="41801" checksum="F307500BE72F5517" modified="2009-09-22" version="1">MKKLLLLSSLTFSLFFTAQTFTQAYQNRVNQIAQTNINTYLTEFAAFGVKTTGSANNNNTFNWLKNKYLSFGYTADQLSENAFTYNGNTTKNLILTKTGTKYPDTFVIVCGHYDTIGGPGVNDNGSGTAILLEMARILKYVPTEYSVKFINFTGEEQGLLGSQKYVSSVVNSTSPKMKIKLVLNIDQVGGVAGEVNNTVTCEQDTNNSPATNNAASAAATQQLMACVGLYSPLQTNLSYAYGSDYMPFQSNGEVITGLYEYNESNTPHTSGDTYVNMDPVFVFNVAKGALGAVQHFAVADSVILSTSDSGISSYRVYPNPASDYLHIESNEDRFELSLADTSGKIVLRNKNVKKINVSHLPSGLYFASLNFDGQLATSKIIIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4G5</accession>
    <name>C6X4G5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ordered locus">FIC_00850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782449.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00850"/>
    <dbReference type="EnsemblBacteria" id="ACU07303">
        <property type="protein sequence ID" value="ACU07303"/>
        <property type="gene ID" value="FIC_00850"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00850"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_10"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="114" mass="13143" checksum="53A36A4735BD0951" modified="2009-09-22" version="1">MPRSVNAVASRARRKKVMKLAKGFFGRRKNVWTVAKNAVQKAMQYAYRGRKEKKRSFRSLWIMRINAGAREHGMTYSQFMGALKSNNIELNRKVLADLAMNHPEAFKAVVDQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4J2</accession>
    <name>C6X4J2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00877"/>
    <dbReference type="EnsemblBacteria" id="ACU07330">
        <property type="protein sequence ID" value="ACU07330"/>
        <property type="gene ID" value="FIC_00877"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00877"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091017_0_0_10"/>
    <dbReference type="OMA" id="AGFCYIE"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24293" checksum="BBDA07DC5F6D8B80" modified="2009-09-22" version="1">MEINDQFIVIVAGEEQLKFVPAVLKEIEESAKERGTGIAKRTASYLEEKINEGKAVMAFSQEGEWAGFCYIETWSNKTYVANSGLIVARKFRNAGLARKIKEVIFEYSRTKYPNAKLFGLTTGLAVMKINSNLGYKPVTYSELTQDDVFWSGCKSCVNYEILMSKERKNCLCTAMLYNPNEGTVPQNINKTESENNQKLFSKFKKIRTMLWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M7</accession>
    <name>C6X4M7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782511.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00913"/>
    <dbReference type="EnsemblBacteria" id="ACU07365">
        <property type="protein sequence ID" value="ACU07365"/>
        <property type="gene ID" value="FIC_00913"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00913"/>
    <dbReference type="eggNOG" id="ENOG502ZCG0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1515742_0_0_10"/>
    <dbReference type="OMA" id="ENYIEYN"/>
    <dbReference type="OrthoDB" id="1414346at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970667" evidence="1">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="19912" checksum="B7B0D89BF88849A6" modified="2009-09-22" version="1">MKKIIAIVCVSLVLQACIVSTAVGAVKGVSKLAYKTVKGTVKGISWTVSKAKGKIDKDRIDGKWKIVGIYKGSFADYEKEQNPETSFETICETGFEQIEFNSRRSKFKPVHCSTDKEEWTKYDLEFGKNPASGERENYIEYNSRNYISVIDVSNKNLTLEGNLTMSGSQVYLLEKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P4</accession>
    <name>C6X4P4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ordered locus">FIC_00931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782528.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00931"/>
    <dbReference type="EnsemblBacteria" id="ACU07382">
        <property type="protein sequence ID" value="ACU07382"/>
        <property type="gene ID" value="FIC_00931"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00931"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_10"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="305" mass="34945" checksum="350D8A141FDEC83B" modified="2009-09-22" version="1">MSTYLTILGFNSAIPTVNSAPTAQFLEMEERCFLIDCGEGTQVQLRKAKARFSKISHIFISHLHGDHCFGLPGLIASFRLLGRETPLHIYGPKGIKEMLETIFRITETHKGFELVYHELESKQSEKIFEDKRVEVFTIPLKHRVYCNGYLFREKPKERHLNMQEISKYPEIETCDYQNIKLGKDFVLNDGYTLKNATLTTDPSKSVSYAFCSDTRYIESIVPIIENVDVLYHESTFLHDLKEMADYTGHTTALEAARIARKANVGKLILGHFSNRYHDLTVFTDEAREVFPNSFLPKALEPVKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W4</accession>
    <name>C6X4W4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic hydroperoxide resistance transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01002"/>
    <dbReference type="EnsemblBacteria" id="ACU07452">
        <property type="protein sequence ID" value="ACU07452"/>
        <property type="gene ID" value="FIC_01002"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01002"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_3_2_10"/>
    <dbReference type="OMA" id="MMVLWER"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="153" mass="18026" checksum="547EB477A1833AF7" modified="2009-09-22" version="1">MQNILPLYSMEDPDTPKLDNQLCFPFYVIAKEITGMYRPFLEELDMTYSQYLVMMVLWEYERLTVNQIGEKLYLDSGTLTPLLKRLEAKNYIVRHRKKEDERVVEVFLTEEGNQLQKKACVIPGKMQQKLDLSEADLSTLKETLSRLLNKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X515</accession>
    <name>C6X515_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805788.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01053"/>
    <dbReference type="EnsemblBacteria" id="ACU07503">
        <property type="protein sequence ID" value="ACU07503"/>
        <property type="gene ID" value="FIC_01053"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01053"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_10"/>
    <dbReference type="OMA" id="KHGAWQQ"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="7"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="107"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="319" mass="34615" checksum="4ECA0B8FB43D19F6" modified="2009-09-22" version="1">MKVLANDGISQSGKNALAAADIELLDAKVSQENLASFINENLVDVLLVRSATQVRKELMDACPSLKIVGRGGIGMDNIDVEYAIEKGLYVINTPKASSRSVAEMVFAHFFSLARFLHESNRLMPLEGDTHFSAMKKSFSSAVELEGKVLGVIGFGGIGKEVVKIGISLGMKVKVLTRKPRTETISLDFFDGQTVNFEISSGNDWDIFLENTDFISINTPKASEYILDTPQFMKMKDGVFIVNTARGGVLNEVALLDFIDNGKVAGAALDVFENEPAPELPLLMNPNLSLSPHLGGNTIDAQEKIGAELATQIIEIKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>C6X530</accession>
    <name>C6X530_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ordered locus">FIC_01068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805803.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01068"/>
    <dbReference type="EnsemblBacteria" id="ACU07518">
        <property type="protein sequence ID" value="ACU07518"/>
        <property type="gene ID" value="FIC_01068"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01068"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_10"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="217"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="227"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="246"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="462" mass="50879" checksum="0D4DF8E012C5D27F" modified="2009-09-22" version="1">MNNDTICALATANGIGAIGIIRVSGSDSIRIVNLIFEGKDLEKANSHTVHYGFIKDGDETVDEVMVTVFMAPKTFTTEDSVEISFHGSPFIGKKILEVLIKNGARMARAGEFTMRAFMNGRIDLSQAESIADLIASENEASRKVALNQLKGGITNEISILRTDLLNFVSLIELELDFAEEDVEFADRDALVQLLRKIEEKLISLIDSFEYGNAIKNGVGVAIIGKPNAGKSTLLNALLKEERAIVSDIAGTTRDTIEEMLHIKGNAFRLIDTAGLRETSDEIEKIGVAKAREKVATAEILVYLIDSTETDISEDVELIRDLARYDLSLIVLLTKTDLPKSALQSEEIRNSLPVLDFKDFHLIPVSAKQNSNLDELKEAFTGYVDDLNSGENNVVITNQRHFEALQHSLQAVHAVHEAVSSRITTELLAYELRNALEYLGEISGEFTNDEVLGNIFSKFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X599</accession>
    <name>C6X599_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805872.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01137"/>
    <dbReference type="EnsemblBacteria" id="ACU07587">
        <property type="protein sequence ID" value="ACU07587"/>
        <property type="gene ID" value="FIC_01137"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01137"/>
    <dbReference type="HOGENOM" id="CLU_1313883_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="24128" checksum="5271028505A13B59" modified="2009-09-22" version="1">MKSTFTFLFIFAIIFAYSQKFQSATLELANGQQKTGLVNAKSLSAKQIKFKTDENAKEETIPNSSLKSIIFMSDHKSYQLDYLTFYTTAKRKQTESNWMLKLVSGYYNLYTVADYSFDKKGNLKLSTHYLVGSTLPEFYYFIKKHDQNTGDFFAVQSPSPTYFGLHKILQENVGRFMADDKNLLAKVESKKYSTKNIEQIVTDYNNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5A6</accession>
    <name>C6X5A6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805879.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01144"/>
    <dbReference type="EnsemblBacteria" id="ACU07594">
        <property type="protein sequence ID" value="ACU07594"/>
        <property type="gene ID" value="FIC_01144"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01144"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_0_1_10"/>
    <dbReference type="OMA" id="KQRFHLC"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1017" mass="116912" checksum="4BE796FA130EB9EC" modified="2009-09-22" version="1">MFINCHTYHSLRYGTLSVTELVKQASECGAEQLVLTDINTVTAVYEFKKECEKFNIKPIAGVEIRKGNELLYITIAQDADGLAEINRLLTRYNCDGAELPQTSPDFNKVTVIYPLENIPESLKENEFIGIKETQLNLLISPKWQRFLNRMVMLHPVTVSTKKEYNLHRVLRAISNNTLISKLTEDDCCAPNEVFKPVEELLESFKMYPQIIENTQRILDFCSFEFDFKKPKNRTFFTGNKASDAQLLRKLAYEGLKKRYPEESEAVLKRTEKELKVIDDLNFSGYFLITWDIIQYSKSRGFMHVGRGSGANSIVSYCLGITDICPIELDLYFERFLNMHRKSPPDFDIDWSWKERDEILNYIFGKYGKDHVAFCGTNVEFKYRSIFREVGKAFGLPKEELDALATKPMDTHDTNSVVKLVHKYGQLLEKFPNQRSMHSCGILISEEPITNYTALEMPPKGFAIVQFDMHVAEDIGFEKFDILSQRGLGTINDTVKLIQKNRGITVDIDDTHTFKNDQNCNAYLSIGKTIGCFYIESPAMRGLLRRLKCDNYKTLVAASSIIRPGVAQSGMMKEYIFRHNNPTQFEYFHDVFKEHLGETYGIMVYQEDVIKIALHFGGLSADDGDILRRAMSGKGRSLAALQKVKDHFFESCREKGHPEKLSQEVYRQIESFAGYSFCKAHSASYAVESYQSLYLKVYYPVEFMVSAINNGGGFYRTEVYVHECRMSGGVIHNPCVNKSGVETTVFGVDVYLGFMHIENLESGMACFIFDERIRNGAYTSLENFIKRVPVGIETLQTLIFVGGFRFTGKQKNELLIEARLLMISFKPQNRLPSFFETPVQEYELPNLKRNRFEDAFDEIEILGFAVSCSPFELLQTKYRGGVRAMDLIKFHKKQVKMLAYLISRKHVPTTKGTMFFGTWIDADGNYFDTAHFPDNLQKYPFQGGGCYLLLGLVEVDFHFPTITILKMAKMPFIPDPRYAEDQEKAFEVHKKINEDVSMTWRQPYPQEKEIGLPRYKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J4</accession>
    <name>C6X5J4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805967.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01234"/>
    <dbReference type="EnsemblBacteria" id="ACU07682">
        <property type="protein sequence ID" value="ACU07682"/>
        <property type="gene ID" value="FIC_01234"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01234"/>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_1_10"/>
    <dbReference type="OMA" id="NEMFAND"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="72"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="321"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="459" mass="51983" checksum="0848FC4A755D8A87" modified="2009-09-22" version="1">MKTNKWIITVTIGVGFLLAPSSCRNLVEPDSPSTQIDVSQVFETVSTADGALSNLYAELQYYSLLSGGSLGMGAMLGTYTDDLQCYIISSQNGAVDLYNNRQISSNTAVLSMWTNAYKEIYSANSIITGVENSTGISETDKKRLKGEALLIRSLIYFYLNQMFGDIPYTTTTDYTVNQSVGKVSRSELLIKIQNDLETAVALLEDPYRNAERIYPNRKVAELMLCKVLMQQKKWNEAEQRLKSIVQSPLYVWQPDLTKTFKKAGKHILWQLKPLKTNDATEEAINYNFTTAVPNTYALSSDLVSSFAAADLRRQHWIKEITINQNPYYRCDKYRNTTANTDEYSVIFRLEEVYLLLAEALANQNKVVDALPFVNAVRQKAGIPALTSSTREDLLNKITEENRKEFFAEHGNRFLTLKRNDRLGTLSTVKPNWQPFHEVWPIPQAEILLNPNLNPQNPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M4</accession>
    <name>C6X5M4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ordered locus">FIC_01264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01264"/>
    <dbReference type="EnsemblBacteria" id="ACU07712">
        <property type="protein sequence ID" value="ACU07712"/>
        <property type="gene ID" value="FIC_01264"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01264"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_10"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="618" mass="69421" checksum="5C4A70AD4DB24CB6" modified="2009-09-22" version="1">MQIIRQKSLLLHRQKTIMQNIRNIAIIAHVDHGKTTLVDKIIHATSVFRENQESGDLIMDNNDLERERGITILSKNISVTYKDTKINVIDTPGHADFGGEVERVLKMADGVLLLVDAFEGPMPQTRFVLQKALELGLRPVVVINKVDKPNCRPDEVHDKVFDLFFNLNATEEQLDFPTFYGSSKQGWFNTSLDQTENIFPLLDGILEHVPAPEAKEGPLRMQIVSLDFSSFLGRIAIGKINQGSVKESEWIGLAQEDGKIVKGKVKELYVFEGLGKKKVQEVKAGDICAIVGFDKFQIGDSFVDLENPDPLPRTAIDEPTLNMTFSINNSPFFGKDGKYVTSNHLKERLMKELEKNLALKVEPTEDANTFLVFGRGILHLSVLIETMRREGYEMTIGQPQVILREIDGVKCEPYESMVVDVPEEFSSRVIDLATQRKGDLHIMETKGEMQHMEFEIPSRGLIGLRSQMLTATAGEAIMAHRFTEYKPFKGSIPGRLVGVLVSKTQGPATEYSIAKLQDRGKFFVDPGEEIYEGMIIGEQNKPGDLVVNIVEAKQLNNMRASGKDKDGSIAPKILFSLEECMEYIQGDEAIEVTPNFIRMRKKILSENERKRIERGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P5</accession>
    <name>C6X5P5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low affinity penicillin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806018.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01285"/>
    <dbReference type="EnsemblBacteria" id="ACU07733">
        <property type="protein sequence ID" value="ACU07733"/>
        <property type="gene ID" value="FIC_01285"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01285"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069104_0_0_10"/>
    <dbReference type="OMA" id="LENLQQW"/>
    <dbReference type="OrthoDB" id="1397707at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970709" evidence="1">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="332" mass="37190" checksum="400525BAF9330A2E" modified="2009-09-22" version="1">MKKILAHSALLCSALFCAQEGTLVYPFLNIPVSARQAAMGGDAVSVRDYDVSFAGVNPALMNIEQDEMIAVNYSSYLADSKYGTISYVRDLQEAHLISFNARYMDYGRMPRTDESANIDGEFGAMDATVGLGYAYQFDEDWTIGGSANFVTSKIDTYTSMAVVGSAGITYHNRQSNETVALVFRNFGYQFKTYNGMRENVAFRVDLGYTKILDEFPLAFTITAHDLQKLNISQDYNNNGQPIRWQRKIADHFSLGAELFPQQAFNIRFGYNIKRGNELAVLDQRSFTGLTAGFGIKISSFRFDYAHVRYHNSSNVNMFGLTLDLIEVGGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S2</accession>
    <name>C6X5S2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Curli production assembly/transport component CsgF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the biogenesis of curli organelles.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806045.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01312"/>
    <dbReference type="EnsemblBacteria" id="ACU07760">
        <property type="protein sequence ID" value="ACU07760"/>
        <property type="gene ID" value="FIC_01312"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01312"/>
    <dbReference type="eggNOG" id="ENOG5032U3R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136740_0_0_10"/>
    <dbReference type="OMA" id="TFNYQWL"/>
    <dbReference type="OrthoDB" id="2085706at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018893">
        <property type="entry name" value="T8SS_CsgF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10614">
        <property type="entry name" value="CsgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="136" mass="14689" checksum="BBFCD456A2E19389" modified="2009-09-22" version="1">MKNLGIIVLLITPFYAASQQFVYKPINPAFGGDTFNYQWLLSSASAQNQFDNNLRGSLGSGGSSLDSFTDNLNRQILSELSRKLFGDQFGDGDLQPGTYVFGSIYLEILQTGQGLLISILNTDTGEQSEILIPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S6</accession>
    <name>C6X5S6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806049.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01316"/>
    <dbReference type="EnsemblBacteria" id="ACU07764">
        <property type="protein sequence ID" value="ACU07764"/>
        <property type="gene ID" value="FIC_01316"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01316"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_0_10"/>
    <dbReference type="OMA" id="RVANNYY"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="446" mass="49931" checksum="E06A157F70129739" modified="2009-09-22" version="1">MKKFAFSLLFIGGLIFGQEAKVLTLPEAISYALQNKADAEKARLDIRRGDAQIAEVKSSAYPNISFGSNTTFNPLLQESVLPGEIFGAPGQQVKVAFGQKYTSSNMLQLTQVLFNQQVFTGLKAAKTTREFYLINAELTEEQIIERVANAYFQVYQSEQMLANAENNLKITNETGKIIKGLFDAGLARKIDFDRTEVAKNNITSSKQQLENAVEISENALKFMIGMPMQQEIDLPTQTFDPTILPDSDPGSFDDRTELRLANKQIELLEWQKKASEAEYYPTVALSANYGFLGQGNKFPWWNGEKNGVFWSDVASIGLNINVPIFNGFATKSRIELNQIEIEKAQADFREAKLGLEMEHKNAVTLLENNMTTINMQLSNVKLAEEVLANTRSNYQYGLATLNEILDAERAVTDAKNNLTRAQLDYKLAEIDLLKSQGKLKTLKETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T1</accession>
    <name>C6X5T1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01321"/>
    <dbReference type="EnsemblBacteria" id="ACU07769">
        <property type="protein sequence ID" value="ACU07769"/>
        <property type="gene ID" value="FIC_01321"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01321"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_3_10"/>
    <dbReference type="OMA" id="IEWHMIG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="234" mass="26808" checksum="998AD27AD98997E5" modified="2009-09-22" version="1">MLYFRCEYKFNMNQELNIRKNYKEQSARIPDGVELVAVSKTHPAEVVQQVYDLGQRIFGENKVQELIAKYPQLPKDIKWHIIGHLQTNKVKYIAPFVDTVQSVDSEKILNEIDKQAAKCERKINVLLQVKIAEEDTKYGLDAEQARTLYQNYLDGKYAHVEITGLMGMATFTDDQEQIRAEFRKLKTLFDELSGARKLTTLSMGMSGDYELAIECGATSVRVGSAIFGHRQYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X632</accession>
    <name>C6X632_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ordered locus">FIC_01422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01422"/>
    <dbReference type="EnsemblBacteria" id="ACU07870">
        <property type="protein sequence ID" value="ACU07870"/>
        <property type="gene ID" value="FIC_01422"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01422"/>
    <dbReference type="eggNOG" id="COG2987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018868_3_0_10"/>
    <dbReference type="OMA" id="LVGDWAN"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="92"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="221"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="444"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="669" mass="75250" checksum="4D4084E491055319" modified="2009-09-22" version="1">MKNYLNRTMTFQEQIQQGIPSELPQPKPYGQNINHAPKRKEILTEEEKKLALKNALRYFEPKFHAELLPEFKDELEKYGRIYMYRFRPDYEMKARDIAEYPGKSEQAKAIMLMIQNNLDYAVAQHPHELITYGGNGAVFQNWAQYLLTMKYLSEMTDEQTLTMYSGHPMGLFPSHKDAPRVVVTNGMMIPNYSKPDDWEKFNALGVSQYGQMTAGSYMYIGPQGIVHGTTITVLNAFRKIKKSPIGGLFVTSGLGGMSGAQPKAGNIAGCITVCAEVNPKITKIRHEQKWIDEIYDQLDELVERVKVAKEKNETVSLAYLGNVVEVWEEFYEAQLTIDIGSDQTSLHNPWAGGYYPAGLTFEESNKMMAENPELFKEKVQESLRRHAAAINKHTEKGTYFFDYGNAFLLEASRAGADVLSENPTIGREFRYPSYVQDIMGPMCFDYGFGPFRWVCTSGKPEDLQKTDEIACQVLEEMIKNSPEEIQQQMKDNITWIKGAQENNLVVGSQARILYADAEGRMKIAEAFNKAIANGEIGAVVLGRDHHDVSGTDSPYRETSNIYDGSRFTADMAIQNVIGDSFRGATWVSIHNGGGVGWGEVINGGFGMLLDGSADADRRLKSMLFWDVNNGISRRSWARNEGAVFAIKRAMEAEPNLKVTLPNFVDEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X636</accession>
    <name>C6X636_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806159.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01426"/>
    <dbReference type="EnsemblBacteria" id="ACU07874">
        <property type="protein sequence ID" value="ACU07874"/>
        <property type="gene ID" value="FIC_01426"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01426"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105362_0_1_10"/>
    <dbReference type="OMA" id="HIYNLIE"/>
    <dbReference type="OrthoDB" id="1933827at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="215" mass="24178" checksum="6A51DFA25917E2AC" modified="2009-09-22" version="1">MKNLLKKITLAIFTVATTTTFSAQKIDAKAKNLLDAVAKTYKSKNNVYFKFVYGTGTGKKVTKTEPGIFYSAGDRYKLKIMGTEQIFDGNKIYNISAEDQEVTIAKPSGSEQMFSPLTYIEEYKKGYNVKYLGKITVNGVNADQIKLTPTKNNGIKEVNLFVNSAKNQLVKLEQFGKDNSVSVIAISNYKENQSLQNSMFSFDKNQYKNYIITEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X658</accession>
    <name>C6X658_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806181.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01448"/>
    <dbReference type="EnsemblBacteria" id="ACU07896">
        <property type="protein sequence ID" value="ACU07896"/>
        <property type="gene ID" value="FIC_01448"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01448"/>
    <dbReference type="eggNOG" id="COG1222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_612144_0_0_10"/>
    <dbReference type="OrthoDB" id="545199at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="166"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="449" mass="51839" checksum="9473054C664BB43B" modified="2009-09-22" version="1">MKLAELAKELNLSTDSFIRFIQDFDLELSECIATDFEVKEDFARFARENLTFLKNYQKDLLQNKSVEDIAGTISQPAEKVADVIRRQQPQIYDNGIFRSTVSSYGIDQKLGGNYQFVYDYFGKKTALSARDFIGYRDLFFHISQTLDPFLNQTPLTDWGIHKPAGIILYGPPGSGKIFWAHKIGQVIGYQFKEVKKYYLGTSFVDGSKTTFNDFLVETMKDDRTLLFMDDFDTTMSERSETKSVASCDEETKEVILHYISHFEDENLLMVGSANTLAGIEREILAPGRFDVVIPVFPPNAQERAEIILYYMTKNLSEDALLMKILIENHADHLPYWKDISQKMKAFSNTMIIDFTQSLKKRIRTHYLKNNSDKIDIGPFLKHALRDASVKLTDEYLNHVAQFISDVTLNNYDDFPQRIEALKLELEKYKIVEAPRKKIGFTHNEEETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X667</accession>
    <name>C6X667_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806190.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01457"/>
    <dbReference type="EnsemblBacteria" id="ACU07905">
        <property type="protein sequence ID" value="ACU07905"/>
        <property type="gene ID" value="FIC_01457"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01457"/>
    <dbReference type="eggNOG" id="ENOG50332NA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198164_0_0_10"/>
    <dbReference type="OMA" id="VHIKAND"/>
    <dbReference type="OrthoDB" id="1981557at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="78" mass="9321" checksum="DDA3DE83A5D0C3FE" modified="2009-09-22" version="1">MKTIEIRAVQFFELLKMRDASMWEIFAQMIDGEEKELIFIDDEKKVLFNYILPQNLEKLNEDRAKFSQEYSDKIAGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X668</accession>
    <name>C6X668_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01458"/>
    <dbReference type="EnsemblBacteria" id="ACU07906">
        <property type="protein sequence ID" value="ACU07906"/>
        <property type="gene ID" value="FIC_01458"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01458"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_0_2_10"/>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="70"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="327" mass="36472" checksum="48FC0EEC0866CE3D" modified="2009-09-22" version="1">MASSNCDDVFSIKFQNSSKIRILIVAEGVMKHQNPNALIKFALMNTSRKGSPDTTFSINCNGRVVDLSVPMVMGILNLTPDSFSDGGKYADLKSALIHTEKMLKDGASIIDIGAQSTRPNAQYLSADEEIKRLGKVISNIKTEFPEVLISLDTFHSEVVEFGFNEGLDIVNDISGGMFDAKMFETVAKTGLPYILMHINPTYEEMHEKSVTEDIILVLNKYFSEKILQLQRFGVKDIILDPGFGFGKRVEQQHIMIDDLKHVGFGRNPLLIGISRKSFIYRPLGKEPLDVNAETQKLHLKVLENGAKILRVHDVAEAKVTIDLFLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X683</accession>
    <name>C6X683_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806206.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01473"/>
    <dbReference type="EnsemblBacteria" id="ACU07921">
        <property type="protein sequence ID" value="ACU07921"/>
        <property type="gene ID" value="FIC_01473"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01473"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105002_0_0_10"/>
    <dbReference type="OMA" id="GTHIMII"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24913" checksum="964E2884D3054EB5" modified="2009-09-22" version="1">MKLYVISGLGADFKVLNKLKFPEKFEVVFIEWLIPERDETFADYVKRMAEKVDDTEPFCLLGYSFGGIMVQEIDKLKPAEKVVIMGSIKSDKEKSRFIKVGEITRIPKYLPENIFTEKSAVAYAFIRRFFDPKNPKLLEYFTVRDPYYLKWSIEKITSWKFDGNPKVIQILGDRDIVFPLKYSKPDYIIENGTHLFPATKPREVSELLEKIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X691</accession>
    <name>C6X691_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806214.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01481"/>
    <dbReference type="EnsemblBacteria" id="ACU07929">
        <property type="protein sequence ID" value="ACU07929"/>
        <property type="gene ID" value="FIC_01481"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01481"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108463_0_0_10"/>
    <dbReference type="OMA" id="STLHDWE"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973742" description="YceI domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="18639" checksum="5761DA0D069192AC" modified="2009-09-22" version="1">MKNVANFKILVLAFGLFSGLVAAQKITSKTVKTTVSGTSTMHDWTMTSNNGTFSANVSGNTLTDVTYTLGAKTLKSGKGPMDTNAYKAMKADKFPNITFTATSVNIGKGTITGKLKVTDVTKTVSFPVTVVKNGTAYTITGTEAIKLTDYGVTPPSFMMNTVKTGNDIKISVNVSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X694</accession>
    <name>C6X694_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamide mononucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01485"/>
    <dbReference type="EnsemblBacteria" id="ACU07932">
        <property type="protein sequence ID" value="ACU07932"/>
        <property type="gene ID" value="FIC_01485"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01485"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586308_0_0_10"/>
    <dbReference type="OMA" id="KVHPRMK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="478" mass="54966" checksum="9003ED783BC01EFD" modified="2009-09-22" version="1">MHVINQKLTPKQKALAINLDANIYGTFAEIGAGQETVRHFFRAGGASRTIAKAMSAYDKDFSDAIYGKEAKNRYVTQNRLRKMLRYEVSLIEERLTRDNNPGRKFFSYANTVTTINFNKTMKGHGWVGLRFQLDEKEDYNEIVLHVKFMENDATLQQETLGSLGVNLIYGAYNLSDNPRHLIESLYDDISTDNVEIDMIDFSGPAFAYVDNRLMSLQLVKNGMTDAVIFNPEGNNMLPADVLYKKNIFAVRGSFRPVTLVNIDMFERGLEMFTKDTCCSFEDTVVLFEITISNLRAAGDIDERDFLDRVDVLAKLGYTVIISNFSEYYRLIDYFANYTNGKIGVAMGVNNLLDVFDENYYKNLSGGILEAFGKFFRQDMTVYLYPYKDPETHDLLTSNNLKVGDNLKELYKYFKLNRRIVDIKDYNPNHSEIYSRDILHKIANHESGWQKQVPDGVAEMIIERGMFGYKEELKLKEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A2</accession>
    <name>C6X6A2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ordered locus">FIC_01493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806225.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01493"/>
    <dbReference type="EnsemblBacteria" id="ACU07940">
        <property type="protein sequence ID" value="ACU07940"/>
        <property type="gene ID" value="FIC_01493"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01493"/>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_1_2_10"/>
    <dbReference type="OMA" id="FYAKSPR"/>
    <dbReference type="OrthoDB" id="1854712at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="207" mass="23450" checksum="CF83AA6F48360D79" modified="2009-09-22" version="1">MKLKVCGLTQPNQVQELISLDVDFLGFIFYAKSPRYVLNHLNLKQISELDHSGKVGVFVNETAQNIAAIAEKATLNYIQLHGDEDENFIDELRDKLVDKEIKIIKVFRIGTDVEKLKFTTQNSLADFFLFDTDSASFGGTGKSFGWQLLNELEIQKPYLLSGGISPENFKDIHNIIQSPFALDINSKFETEPGVKDLQKIKQFYGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A5</accession>
    <name>C6X6A5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase, amidotransferase component</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806228.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01496"/>
    <dbReference type="MEROPS" id="C26.A25"/>
    <dbReference type="EnsemblBacteria" id="ACU07943">
        <property type="protein sequence ID" value="ACU07943"/>
        <property type="gene ID" value="FIC_01496"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01496"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_10"/>
    <dbReference type="OMA" id="HQVVIYR"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="21008" checksum="4AEEDD04EE09E493" modified="2009-09-22" version="1">MKILVFDNYDSFTYNLVQMIEQITGGKVDVFRNDGIPIENIEAYDKIILSPGPGIPEEAGILLDVIKKYAPTKSILGVCLGQQAIAEAFGGSLINLSEIFHGVATESKQIRPHRILNDLPETLEVGRYHSWAVNPTDFPEELEITSVDQSGMIMSLKHKTYNVHAVQYHPESILTPDGRKILENFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B1</accession>
    <name>C6X6B1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806234.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01502"/>
    <dbReference type="EnsemblBacteria" id="ACU07949">
        <property type="protein sequence ID" value="ACU07949"/>
        <property type="gene ID" value="FIC_01502"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01502"/>
    <dbReference type="eggNOG" id="ENOG5032S94">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010820_0_0_10"/>
    <dbReference type="OMA" id="INSTGFM"/>
    <dbReference type="OrthoDB" id="1624082at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PdaC" evidence="2">
        <location>
            <begin position="57"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="1">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="269" mass="30497" checksum="FF604084DFE2BC76" modified="2009-09-22" version="1">MKNLPAIFSVLLLVFSACSEKKALPENPQETKSVTPAKDIFANDSVGVDDSLKLGENVMAKFKIKSLVFANITDKTLLDSIYATQNIKADDYSKKGLLAALESQKTEFYEGTKESLKDWAPEFPQTWEQNSAMKLFSKSDDFLTVQYTSDGYTGGAHGYYNELYKVFDIKTNKTLQLADVIKDQDATIWGRVLMAHFLKNDLERNQAQMLLVKQIPLNTNFYFDAENLYFLYNQYEIAAYAAGPVLIQIPFTEIKPLLDSAFRQKLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D9</accession>
    <name>C6X6D9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806262.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01530"/>
    <dbReference type="EnsemblBacteria" id="ACU07977">
        <property type="protein sequence ID" value="ACU07977"/>
        <property type="gene ID" value="FIC_01530"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01530"/>
    <dbReference type="eggNOG" id="COG1090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047373_0_3_10"/>
    <dbReference type="OMA" id="YMPWIHI"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="298" mass="32643" checksum="FF277A0D1C1119B3" modified="2009-09-22" version="1">MNILITGGSGLVGQALVAQLTKSGHAVRILTRKNTANPAEFQWDLAKNYIDGKAFENLDAIIHLAGANISQRWSESYKKELFSSRVASAKLLKEYCVKHDVQLKAFISASGINYYGTFTSDRILPESSGIIQPGFLTRLCEEWEAAANSFSEISNRVVCLRTAMVLSEDGGAYPLLKKVADFNLSSAIGSGTQWMNWIHAEDLAAMYVFAIENNAVSGAYNAVADEIPTNQVFMKKLASVNGKIFLPVNIPTFVMKSVFGKMSSVILEGTRAGNEKIKSLGFDFKYAKIEDAFQALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E6</accession>
    <name>C6X6E6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01537"/>
    <dbReference type="EnsemblBacteria" id="ACU07984">
        <property type="protein sequence ID" value="ACU07984"/>
        <property type="gene ID" value="FIC_01537"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01537"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017692_1_2_10"/>
    <dbReference type="OMA" id="ADINPRH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973649" evidence="2">
        <location>
            <begin position="36"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="475" mass="52636" checksum="43EC5B874AA23200" modified="2009-09-22" version="1">MYVIRQCGISLYLKIKTHMNRLIVVALMASNVAFAQNVGQKLRTATQNLLASTPAYSANLSVYVADENGEFVYEYNGNQGLSTASTQKIFTAAAALETLGTNYQYTTTASYSGTISNGNLSENLYIQSNGDPTLGSWRYDGYKPENFRNKLIEALRQKGIRKVSGDLVIDDSYFNFQTVPGGWPWNDIGNYYGAGVWGVNWRENQFDLNMNGKEMKGQNVDLPNVAWVNDLKTGGSSDQSLIYTAPFSDVAYISGTLPAKNITVSGATPNPPLTLGMEIKTWFNEAGIEFNGKVTTASMQQINGEKIPVAPKSNIILEHKSPTLDKIVYWFMRKSVNFYGETLIKTLGKEKKNEGSFDAGIAYLKEFWKGKGISPAMINFADGSGLSPQNYVSARAEVQSLLWSRKQPWFNAFFEGFPTQTNSMKMKSGTMKDTKSFAGYHTSKDGKKYVFAIIINNYQGSNSSEALYKVLNVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK8</accession>
    <name>C6WZK8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ordered locus">FIC_00067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781690.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00067"/>
    <dbReference type="EnsemblBacteria" id="ACU06543">
        <property type="protein sequence ID" value="ACU06543"/>
        <property type="gene ID" value="FIC_00067"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00067"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_1_10"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="185"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="305"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="398" mass="43481" checksum="AC51A9CF1A04879B" modified="2009-09-22" version="1">MAIQGKKILICVSGGIAAYKINFLIRELIKKNCEVQVLMTPAAENFVSKLTLSTLSKNPVYSDFYSDNGTWNNHVEFGLWADLILVAPCTANTLAKMVHGLCDNLVLATYMSAKCPVMIAPAMDLDMYQHPSTRQNLELAEDFGHIIIPAETGELASGLVGQGRMAEPETIAEHIEHFFNQTKSLSGKTVLITAGPTYEPIDPVRFIGNHSSGKMGFAIAEEAASRGAKVILVSGPTALQPINANIAIHRVTTAREMFNETLKHFGAVDIAIASAAVADYAAKEIATEKIKKKDENLTIELIKNPDILRTVGERKTGQFLVGFALETQNEEENAMAKLEQKNLDMIVLNSLRDEGAGFQGDSNRIKILTKNSTEVFGLKPKKDVAKDILNLVEKLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM9</accession>
    <name>C6WZM9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781711.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00088"/>
    <dbReference type="EnsemblBacteria" id="ACU06564">
        <property type="protein sequence ID" value="ACU06564"/>
        <property type="gene ID" value="FIC_00088"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00088"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_0_10"/>
    <dbReference type="OMA" id="MYHHIIN"/>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="266" mass="29151" checksum="A71ADFA515856B5F" modified="2009-09-22" version="1">MEFLGYFSAIVIGLVMGLIGGGGSILSVPIFVYVFGFDAVTATALSLFVVGITSLVGSVGFIKQGQIDFRTALTFAIPSVLGVLFSRRLVLPHLPHYIINRWGITLTKDMFLLLLFAILMLIASIKMIRKNERPRLRKYDEVNYTILVSQGLLVGIVTGLIGAGGGFLIVPALVMLLGLNMKKAVATSLFIIAMNSLIGFLSTMKIVKHDWVFLLSFTSLSVIGIFIGLALSKRMDGRKLKPLFGWIVLAMGLFIIVKEVFLKQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZS7</accession>
    <name>C6WZS7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00137"/>
    <dbReference type="EnsemblBacteria" id="ACU06612">
        <property type="protein sequence ID" value="ACU06612"/>
        <property type="gene ID" value="FIC_00137"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00137"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050201_0_0_10"/>
    <dbReference type="OMA" id="ISESIWH"/>
    <dbReference type="OrthoDB" id="1388617at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="319"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="426" mass="48047" checksum="44D62312C51A1616" modified="2009-09-22" version="1">MPKMKPKSVLQSFLARFVILGLNFGLLIFTTNMWGTEGKGVIALVIADLAIVGFFSNIFTGSSVSYYSSKFQSEQVISRAYVWSVVSGILFPVALSLLHPIDYLYYLIVLSVAFSLLTTNINLFIGRQEIGKFNLYSVLQQAVHFASILALIYIFKMESVEVYFISLSACYVILFITSSYYLLKGFRIFNVSYSRNVFRNLFGYGWKSQLSAFLQFLNNRASFYFLEYFRGIASVGVFSVGVAFSEAIWTVSKSLSVILYSDLVSRDNQHDAIEKTKVSLRVSFLISLFFIAVILMIPGSWYAAVLGQDFVGIRKITLLLSPGILAIAVSNIVGHYFAGVNKLRILNIKSLVGLFFTIVASTVVIPRWGIYGACIITTVSYFLSSGLLFWRFYQITEFRFSDFLLTKVELKLLLNKMRALIIPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT1</accession>
    <name>C6WZT1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heavy-metal-associated domain (N-terminus) and membrane-bounded cytochrome biogenesis cycZ-like domain, possible membrane copper tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781763.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00141"/>
    <dbReference type="EnsemblBacteria" id="ACU06616">
        <property type="protein sequence ID" value="ACU06616"/>
        <property type="gene ID" value="FIC_00141"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00141"/>
    <dbReference type="eggNOG" id="COG2836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032635_1_0_10"/>
    <dbReference type="OMA" id="GRISTYM"/>
    <dbReference type="OrthoDB" id="1818448at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="247" mass="26902" checksum="FAD89C372FFD32ED" modified="2009-09-22" version="1">MEVTLIFAALALGFASGFHCIGMCGPIALSLGLTRKQATNYYLQNLTYQFGRIATYAFLGAVLGIVGQGFQMAGFQQYLTVTVGILLILMALFSFGGKDFASKIPFMSSFLFKVKKNLGKLLQKADYRSRFTTGILNGFLPCGMVYMALTASLAAGGVWQSAGFMALFGLGTLPFMFAIVLVGNLMTTAFRIKILKFVPVMMLILGGLFVVRGLEMGIPYLSPKKEALHVIHNNSEEHNHGNHETCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU2</accession>
    <name>C6WZU2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Haem_bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781774.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00152"/>
    <dbReference type="EnsemblBacteria" id="ACU06627">
        <property type="protein sequence ID" value="ACU06627"/>
        <property type="gene ID" value="FIC_00152"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00152"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120447_1_0_10"/>
    <dbReference type="OMA" id="KVQPVAW"/>
    <dbReference type="OrthoDB" id="1935300at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025992">
        <property type="entry name" value="Haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14376">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01235">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haem_bd" evidence="1">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="152" mass="17764" checksum="B793A09C2AE3ED40" modified="2009-09-22" version="1">MKIFKKISFWSLIVIAVMQFIPIDRVNKPVDAKVNFVNVFKTPPAVRNILIKACYDCHSNETVYPDYAYVAPVSWSIKNHISEGREHLNLSEWGNYNEYLKKSMLENTVRSVRQYEMPLPAYITKHPTANLTKEERELLANYFENILKSGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW8</accession>
    <name>C6WZW8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00178"/>
    <dbReference type="EnsemblBacteria" id="ACU06653">
        <property type="protein sequence ID" value="ACU06653"/>
        <property type="gene ID" value="FIC_00178"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00178"/>
    <dbReference type="eggNOG" id="ENOG5033EBG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2567651_0_0_10"/>
    <dbReference type="OMA" id="AFFNREW"/>
    <dbReference type="OrthoDB" id="2016077at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="79" mass="9235" checksum="B6E55385E3E877D2" modified="2009-09-22" version="1">MEAILIIAAAGVIIYYFRNSLRRKVFGGEQKYQSIDDRFNEDKRARELEIDRLLSKMGKNGLADLSEKDRKRLDELSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X045</accession>
    <name>C6X045_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781877.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00257"/>
    <dbReference type="EnsemblBacteria" id="ACU06730">
        <property type="protein sequence ID" value="ACU06730"/>
        <property type="gene ID" value="FIC_00257"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00257"/>
    <dbReference type="eggNOG" id="COG2370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109303_0_0_10"/>
    <dbReference type="OMA" id="GFQPNTK"/>
    <dbReference type="OrthoDB" id="760572at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032809">
        <property type="entry name" value="Put_HupE_UreJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13795">
        <property type="entry name" value="HupE_UreJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="192" mass="21950" checksum="240609A3A0AD1766" modified="2009-09-22" version="1">MQDFIFYLKLGWEHIISLDALDHQLFVLVLVAVFGLKDWKKILWLVTAFTIGHSITLAMSVLDFVRVPGKWVEFLIPLTIFITAVDNILMRNRQKSLMQMNYYLALFFGLIHGMGFANTARMMMAEEQHIFVPLLGFNIGLELGQIIVVGLILAVQYIIVNLFKANRKDWIMFVSAGVFALSLQMALERIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X055</accession>
    <name>C6X055_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome hibernation protein YhbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781887.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00267"/>
    <dbReference type="EnsemblBacteria" id="ACU06740">
        <property type="protein sequence ID" value="ACU06740"/>
        <property type="gene ID" value="FIC_00267"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00267"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_5_0_10"/>
    <dbReference type="OMA" id="QCKSFEE"/>
    <dbReference type="OrthoDB" id="2088581at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="10817" checksum="1303FD73DE3CA7FA" modified="2009-09-22" version="1">MKISVQSIGLTPHAPLEEHIEKKLSKLETYYDKIVECTVFLKVENKSDKENKTAEIILAVPGDDIVVKKTTSSFEESLDQCAEVAKRLLIKKKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X074</accession>
    <name>C6X074_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781906.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00292"/>
    <dbReference type="EnsemblBacteria" id="ACU06759">
        <property type="protein sequence ID" value="ACU06759"/>
        <property type="gene ID" value="FIC_00292"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00292"/>
    <dbReference type="eggNOG" id="COG3339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2092011_0_0_10"/>
    <dbReference type="OMA" id="YLAWEIL"/>
    <dbReference type="OrthoDB" id="2017850at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF1232" evidence="5">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="112" mass="12398" checksum="A293ADB302C86A26" modified="2009-09-22" version="1">MKLSKIALAREAFRHKGFIGKIPVITRMVKSVMSKNGYRPNYKNVVLPGLVLVYLISPIDILPDWIPLIGVLDDLALLAFAIPMLIKEAEKFVAWEATSKGDPHISDAEVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X075</accession>
    <name>C6X075_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ordered locus">FIC_00293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781907.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00293"/>
    <dbReference type="EnsemblBacteria" id="ACU06760">
        <property type="protein sequence ID" value="ACU06760"/>
        <property type="gene ID" value="FIC_00293"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00293"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_10"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="302" mass="34662" checksum="CFEAF55B05478BB5" modified="2009-09-22" version="1">MKNLISTVGTTGIGKTKLAIALAKHFGTEIVSCDSRQFFREMNIGTARPTDSELAEVPHHFIGNLSVEDYYSVGQFEKEALKKIDELFLQNKVAVMVGGSMMYEKAVIEGLNELPEADENNQKKLDDIIAAEGITALQKILLDLDPEYYGTVDQNNSRRLLRAIDIIWQTGKSYTENIASQVSDRDFNVIRIGIQAPRETVYERINQRVDRMIDEGLLEEVRGLIPYRNLVSLQTVGYSELFKYFDGDWTLDFAVEEIKKNSRRFAKRQLTWYRKETNIHWVRFENAVEESLSLLKNLNIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X088</accession>
    <name>C6X088_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ordered locus">FIC_00306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781920.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00306"/>
    <dbReference type="EnsemblBacteria" id="ACU06773">
        <property type="protein sequence ID" value="ACU06773"/>
        <property type="gene ID" value="FIC_00306"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00306"/>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047382_0_0_10"/>
    <dbReference type="OMA" id="CFCSTMN"/>
    <dbReference type="OrthoDB" id="613347at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="339" mass="37547" checksum="8F793AACE3907C0B" modified="2009-09-22" version="1">MSTETLDKAKSNLPVRGFLKIDDLFIPQGEELVQAILDLKKEKNAVILAHYYQPPAIQDIADFLGDSLQLARQAKDTDADMIAFCGVHFMAEAAKILNPTKKVVLPDTQAGCSLADGCSGEGLRAMRAKHPNALIATYINCNAETKAESDIIVTSSNAETIISSLPTDRPIIFAPDKNLGAYLAKKTGRDMILWDGTCIVHEAFSMERIAQQLAAVPGAKLIAHPESESAVLDLAHFVGSTSALLNYVEKDEAQIFIVATEEGILHEMRKRAPHKQLIPALVFDESCNCSECFYMKRNTMEKLYLCMKYELPEIIMDEELRLRALKPIEAMLEMSKMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X096</accession>
    <name>C6X096_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00314"/>
    <dbReference type="EnsemblBacteria" id="ACU06781">
        <property type="protein sequence ID" value="ACU06781"/>
        <property type="gene ID" value="FIC_00314"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00314"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_1_1_10"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="406" mass="46428" checksum="C5319D6BD0F51DBC" modified="2009-09-22" version="1">MPALNLPLSGLRTSRFLLLPFAFFLFPCVFPMIYLHIPFCKQKCSYCNFHFSTSLKHKDEMMAAMKKEIFLRKDELDSKILKSLYFGGGTPSILGADELKSVIDEVLKFFEFDSDIEITLEANPDDLDATFLKGISQTPINRLSIGTQSFFNDDLKMMNRAHNASEAEGSIKRAQDFGFENISIDLIYGSPTSDFEIWKQNLNMALALEVPHISAYALTVEPKTALNQWIQQNKIQAPKEAEQTEEFYYMSDFLKNHGFDHYEISNFGKPGFHSQHNSAYWKSHEYLGLGPSAHSYNGGNERSWNIANNQLYINSLNQNKLPKETEVLSESEQFNEMMMIGLRTLTGVDLADLNNRFGDDVRQHLEKETKQRIADGILTVENNHLRIPEKHWFLADGIASDVFMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B6</accession>
    <name>C6X0B6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, GT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00334"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06801">
        <property type="protein sequence ID" value="ACU06801"/>
        <property type="gene ID" value="FIC_00334"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00334"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_0_10"/>
    <dbReference type="OMA" id="HIRICAV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="341" mass="39403" checksum="990C4BCBA266BF2E" modified="2009-09-22" version="1">MKEMPPTPIIPLISVLIPTFNDDIFIANCLDCVISQTMADIEIICIDDGSTDSTPEILREYALKDDRIRYIIKPVNQGVSDARNDALRLANGKYFLYVDGDDLMDENLLKKAYLLAVSTDSDIVMWDYLTFNNYSEISEKKNKNSDLKPEDSNDKVALLQRPAFSWMKLVKTATARSLGISFPKGLIREDIPVHWHLLTSVDKIAIIPEKLSYYRQNPSSLTHKNDRTVLDIAAIMDIVKAYLISNNLYNIYKNEFLRQQINLLHGMYDNINEEFKADALILIKDRFSQEQLLFIKQNNVVRKQAKYFYLGLAANRFYKVIYWGWVALRGIYRNLTSYIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E7</accession>
    <name>C6X0E7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00366"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06833">
        <property type="protein sequence ID" value="ACU06833"/>
        <property type="gene ID" value="FIC_00366"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00366"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_0_10"/>
    <dbReference type="OMA" id="NEICDIN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="319" mass="37285" checksum="E92F92050B2E578A" modified="2009-09-22" version="1">MLKMNLTVIIPIYNAEKHLEKCINSVLNQACGDFELLLINDGSTDQSGKICERFAAKDQRIKIFRQRNSGVSAARNLGIENAAGKWITFIDADDYISANYFKVLESETDVDIILQGLTYVEDSNVIKHIAYQAEKLVLEEFMWKYTVYPYFSSSWSKFFKLEILKQQKISFNERLTFGEDTLFNLNYLRFCKLIMTSDFSGYCYRVLNSGLANSAYSYQHDLSLYRAFEDLRSKYRNRAFFEESIKIPLSRLSKAIYYDKTIQTAERRKILKEIVEAHYDIVLRIYTDPKVKVFFVTAYYTGFYLVLDFVLSNLARKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G8</accession>
    <name>C6X0G8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable signal peptide protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00387"/>
    <dbReference type="EnsemblBacteria" id="ACU06854">
        <property type="protein sequence ID" value="ACU06854"/>
        <property type="gene ID" value="FIC_00387"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00387"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074553_0_0_10"/>
    <dbReference type="OMA" id="GLVWEWT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972169" evidence="1">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="281" mass="31870" checksum="D0BEBEF9EDEE6CF3" modified="2009-09-22" version="1">MQVFLKTILFLGGFFLIFQSCGEAAEPISTVFASPEKEAKINPTVKMVVIKGGEYQPFYGEDSSLVEVKDFLLDERPVTNAEYLDFVKKNPQWKRSKAKAIFADETYLQNWQDDETLPKGADPDAAVTFVSWFAAKAYAESAGKRLPTIDEWEYVAMADEESANGRDKPEYSSKLINLYNEKDRQTRKTKLSEPNYWGVYNMFDLVWEWTDDFNSIMTTSDTRSGTFDDKGLFCAAAATTSTDALNYASYMRYAFRASLKANFTVANLGFRCARDLKTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J3</accession>
    <name>C6X0J3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00412"/>
    <dbReference type="EnsemblBacteria" id="ACU06879">
        <property type="protein sequence ID" value="ACU06879"/>
        <property type="gene ID" value="FIC_00412"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00412"/>
    <dbReference type="HOGENOM" id="CLU_1218309_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13648">
        <property type="entry name" value="Lipocalin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin-like" evidence="2">
        <location>
            <begin position="104"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="227" mass="25375" checksum="6253CF2B1F7061C2" modified="2009-09-22" version="1">MVWGKNSAELYTGVMIEIWGMHLCLYKDINMVHFISIYGIILENAINITITYISTMKTKINGLFNAKQLQVVLKLPFLLLLLAFTLVACRDNENEDRPESDLFGLWQPYKMTQTATLSTSPYSVSTEYSICEQKGRILFTDDGLGNAKTYSEANGPCILQDDSNFTYTYDALTNTLVITSANGTSQTGSIKELSESNLVYELVGSYDFQGEQNVTVTTTVTARKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N7</accession>
    <name>C6X0N7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GldD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00461"/>
    <dbReference type="EnsemblBacteria" id="ACU06923">
        <property type="protein sequence ID" value="ACU06923"/>
        <property type="gene ID" value="FIC_00461"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00461"/>
    <dbReference type="eggNOG" id="ENOG502ZRB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118000_0_0_10"/>
    <dbReference type="OMA" id="QFYVTDS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019850">
        <property type="entry name" value="Motility-assoc_lipoprot_GldD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03512">
        <property type="entry name" value="GldD_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="208" mass="24008" checksum="982ECB7021FA7F52" modified="2009-09-22" version="1">MPPAIYCGEVHLKNLISNLYFCAMLKKLVFTFLGLGLISCAEEAQPKPSGELRLEYPEAVYQKYTSPCGFSFEHSTLANIENAKNNCWYYISYPGMKAKVFITYFPVNNDFPLHVKESEKMVYEHTIKASAIDTKSFSYPERRIFGNFYELKGPTASNLQFFVTDSTRHYVTANLYFNTRPKPDSLAPAIDYIKKDLLHLIDTFEWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0W7</accession>
    <name>C6X0W7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA/MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806365.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01635"/>
    <dbReference type="EnsemblBacteria" id="ACU08080">
        <property type="protein sequence ID" value="ACU08080"/>
        <property type="gene ID" value="FIC_01635"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01635"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047813_0_0_10"/>
    <dbReference type="OMA" id="NIPEFGI"/>
    <dbReference type="OrthoDB" id="2018797at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009282">
        <property type="entry name" value="DUF937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06078">
        <property type="entry name" value="DUF937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="315"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="427" mass="44781" checksum="ACC2611E48E974E5" modified="2009-09-22" version="1">MALNVIDLIRGQLGPALVTQSATKLGESESGISKAISALLPAVVGALADNSDKPGVLESITGSASSGILGNLLDGAAGNSMVATVLQAIFGDKVPGLVNAVSGYAGVSNTSANSLLYTVTGATIGSVGKYAQDQNMDASGVAGLLNEQRGTVASLLPAGLSLASLGVGNLANGDEYPETAKITAETHDAPKVEVNRGGNTHVHVDNNDAHKDNGSVWKWLLPLLLLALAAWFLWKQCDRKTTENTVVTDSVVTDNDSAAIINDTASIGTTSMANRETTTVSLPAGQTLNAYRGGIEDQIVAFLNSEEYKNADETALKERWFNFDNLSFEFNSTKLTPESQTQLDNIKAILAAYPDAKIKIGAYSDKKGDDAANKTLSRQRADAVKSALASAQVISAEGYGEERATVAETASDEEREKDRITAIRFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y0</accession>
    <name>C6X0Y0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipoprotein releasing system transmembrane protein lolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806378.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01649"/>
    <dbReference type="EnsemblBacteria" id="ACU08093">
        <property type="protein sequence ID" value="ACU08093"/>
        <property type="gene ID" value="FIC_01649"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01649"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_10"/>
    <dbReference type="OMA" id="FIGARYT"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="402" mass="44708" checksum="EC85D2865781CFA3" modified="2009-09-22" version="1">MKNTPFYIARRYLLAKKGSTAVTFITWLAALAMTVATTAMFIIISVFSGLEDLNQDLIANLHADLTLKSKTGKTLPSIEKAEKILQAEPEIAHFSKVIEEKVYINFRENGDIANLRGVDSAYVLVNPIDKNIFYGSYPSFKYSNEVLLENKLDNRLSIPVGESSEVANLMMPKPGTGMISKEEDIFNKRDIFVSGVFPGNDQLDNTIISPIELSRELLDLPKESAYQIVIKLKNPYHTDAVKARLQNKLGAKYILTTKSEENAAFWKMINTEKLFIYLIFALVIFITTFNLAGAIIILQLDKKEQAKSLISLGLNLKSLRNIYFYTGVLIVGFGIVSGLLLGTVICYIQIETGIFKAGAGTDLAFPVRIRLLNYITVAGTAAVFGLAVSWFFSKINRSNITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X129</accession>
    <name>C6X129_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5606 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806427.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01699"/>
    <dbReference type="EnsemblBacteria" id="ACU08142">
        <property type="protein sequence ID" value="ACU08142"/>
        <property type="gene ID" value="FIC_01699"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01699"/>
    <dbReference type="eggNOG" id="ENOG502ZPSM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118060_0_0_10"/>
    <dbReference type="OMA" id="DEDRVYA"/>
    <dbReference type="OrthoDB" id="1695187at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041218">
        <property type="entry name" value="DUF5606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18347">
        <property type="entry name" value="DUF5606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5606" evidence="2">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="186" mass="20557" checksum="AC6BFF41F02A048C" modified="2009-09-22" version="1">MQLEKIISISGKPGLFKLISQLKSGFIIEDVLTKKKVSIGNTSQVSLLDNIAMFTFDKEVPLFEVFENLAKSSDYKETISHKSTDAELRELMQTALPDYDTERVYVSDMKKLAQWYNILHKAGYITPESFVKSEEATEESAGDAITTDKKEGKTAAPKTEKTSAPKVKASTSSAKGAPKSTHRKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C6</accession>
    <name>C6X1C6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806524.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01796"/>
    <dbReference type="EnsemblBacteria" id="ACU08239">
        <property type="protein sequence ID" value="ACU08239"/>
        <property type="gene ID" value="FIC_01796"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01796"/>
    <dbReference type="eggNOG" id="COG5646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119457_0_0_10"/>
    <dbReference type="OMA" id="YGMIGYV"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="151" mass="17424" checksum="E71F380BA598F22B" modified="2009-09-22" version="1">MQIAANTIAEYLSGVPEDRKEAFTKLYKTISENIPEGFQENISYGMIGWSVPLETYPAGYHCTPGAPLPFINLASQKNFIALYHMGIYAEPELLDWFVQEYPKHSARKLDMGKSCIRFKKPDEIPFELVAELVKRRSPQDWIALYEKLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D3</accession>
    <name>C6X1D3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806531.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01803"/>
    <dbReference type="EnsemblBacteria" id="ACU08246">
        <property type="protein sequence ID" value="ACU08246"/>
        <property type="gene ID" value="FIC_01803"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01803"/>
    <dbReference type="eggNOG" id="COG1407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075478_1_0_10"/>
    <dbReference type="OMA" id="WINGNHD"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026336">
        <property type="entry name" value="P_estr_lig_assc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04123">
        <property type="entry name" value="P_estr_lig_assc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="214" mass="24324" checksum="0838ED1BB0F8F78E" modified="2009-09-22" version="1">MIKTLEKTIRNEHLIFTNRKAMFWKRENALIISDLHVGKSAHFRKSGIAVPSQILVDDLEVLEKLIRHFSVKKLIIVGDLFHAGYNSDLEIFCTWREKFNQIEIILIKGNHDRVPKKFYEDNCISTIDAVLEIPPFTFIHEPEIKDGGFTVSGHIHPGVVLAGRGRQIIKLPCYAVSDSQIILPAFSKFTGLDTRTLNTGFQNIAFTEGTIFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F2</accession>
    <name>C6X1F2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806550.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01822"/>
    <dbReference type="EnsemblBacteria" id="ACU08265">
        <property type="protein sequence ID" value="ACU08265"/>
        <property type="gene ID" value="FIC_01822"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01822"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_2_2_10"/>
    <dbReference type="OMA" id="GHDWFHI"/>
    <dbReference type="OrthoDB" id="1798994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="218" mass="25049" checksum="D62EB7CA85B24882" modified="2009-09-22" version="1">MPTDLIENTVDFVKATLEGAEAGHDWFHTERVWKLARKLAQVEQCNLQIVELGALLHDIADPKFHNGHENLAIRISQEFLQSHGASPSVISEVLFIIRNISFKNRNEAPAELPIELKIIQDADRLDAIGAIGIARTFNFGGFKNNLMYHPDIQPKMNMSKEEYKKNDGTTINHFYEKLLLLKDLMHTESAKKIASERHDFMLKFLAEFKKEWNVDDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J0</accession>
    <name>C6X1J0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806588.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01860"/>
    <dbReference type="EnsemblBacteria" id="ACU08303">
        <property type="protein sequence ID" value="ACU08303"/>
        <property type="gene ID" value="FIC_01860"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01860"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_10"/>
    <dbReference type="OMA" id="IAKCPIV"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="587" mass="66504" checksum="26B64319765DAB70" modified="2009-09-22" version="1">MNFAAFLNTNSERFPTKPAIGFKKKEDWKEINWFDFRRMIFKTANALRDAGISGHDKVAIYADNSAEWIVFDLAIMSLGAVTVPIYSTNNGEQAEYIINDSEAKLILVGNQEQYDAAYEILEKNGSLQQIVAAKKAIWIKKDRSHYFQDFIKDGDETFEIVKRENDDLATIIYTSGTTGIPKGVMLTHGNFHQCITAHFDFFKFKNFENETSLAFLPLTHVFERSWTLLSLFGGAKVYFLENTKLIAHALTEVKPTMMCAVPRFYQKIYAGVQEMVENGSATKKKIFNWAVEVGTETGEHKRLDQQIPLVLKLKNNVADLLVFNKIKKKMGGRLWFMPCGGASVSPEVTRFFDALGVHMTVGYGLTETTATLTAFPFKHYEHGSAGIPLGDTQLKIGENDEILAKGSGIMNGYYNLPDETSAVFTDDGWFRTGDAGRFDINGNLFITDRIKDLMKTSNGKYVTPQPIENLLSNNTYIAQAMIVAEGKPFVTALIIPNFEALKEQLTRMNLPFTSWQELVNSDKIKEFYREKLEEVQKGLSGFEKVKKFVLMPSEFEINLGEITPTLKVKRNVVMQKYAQLIDKMYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K9</accession>
    <name>C6X1K9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806607.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01879"/>
    <dbReference type="EnsemblBacteria" id="ACU08322">
        <property type="protein sequence ID" value="ACU08322"/>
        <property type="gene ID" value="FIC_01879"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01879"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_1_10"/>
    <dbReference type="OMA" id="GETNSYR"/>
    <dbReference type="OrthoDB" id="233664at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973345" evidence="5">
        <location>
            <begin position="23"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="81"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="297"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="595" mass="66551" checksum="4CCC35F7E87B0DC7" modified="2009-09-22" version="1">MKISIKLSVLLMSLAVLSCKQLGDDLLTVDAPSSSSEAVIFSNPDLAKGAVDGIKVPMAETNSYRGRWIPFYGMNTDTEWLNSSESTSNDNADLVVYDPKPNNSQMNTANNVWAMMYSGIERANLCIRGLRTYGNPTPGSELGYLLGEALTLRAVYYSDLVKGWGDVPARFEPITTETVYMPKSSRDVIYKQLLADLAEAETLVPWPNGNAATASVERINKAFVKGLRARVAMAASGYSQYPDGIRRSNDPELSVATLYPLALQLCRDVINSGSAHLEPTFEGLWKKYNQEVLAAGNESLWEIPFSSGRGRVLFTFAVNHTNNNQYQQMGNNRGGQGGPLPNVFYDYDQTDQRRNVTCVPYKWGSAVAGKAKQEVGAFNRWYFGKYRFEWMNRLVTSTNDDGVNKIYMRYAEILLMAAEAANEIEGPAAAAPYLKQIRNRAFAPADRPVKVENYVNALTSKSAMFNAIVEEHKYEFTGEMERKLALIRWNLLGTRMADAKARLTELKNRTGRYEDVPSTLYYKYATDNETLIIYGLNRGEFTNPGTGWTAVDWTSLSDSKIASLYRNNPDTKQFWPIWQVFIDSSNGTLANDYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1N2</accession>
    <name>C6X1N2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_01903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806630.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01903"/>
    <dbReference type="EnsemblBacteria" id="ACU08345">
        <property type="protein sequence ID" value="ACU08345"/>
        <property type="gene ID" value="FIC_01903"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01903"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_10"/>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="332" mass="37957" checksum="F31E7FCC53B14FEE" modified="2009-09-22" version="1">MIKIGNIELPEFPLLLAPMEDVSDPPFRRLCKMHGADLMYSEFISSEGLIRDAMKSRKKLDIFDYERPVGIQIFGGDEEAMALSAKIVEAVEPDIVDINFGCPVKKVVCKGAGAGVLKDIDLMIRLTKAVVSSTHLPVTVKTRLGWDTEGINIMEVAERLQEVGVKALTIHARTRAQMYKGEADWNYIHAVKNNPNIEIPIFGNGDVDSPEKALEYKQKYDCDGIMIGRGAIGYPWIFNEVKHFFATGEKLPEPTISQRLEAVRQHAEWSMEWKGERLGLIEMRQHYSNYFRGIPHFKDFRRKFLEVFTLDEMDEVIAEADDFYKEFQFQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1N5</accession>
    <name>C6X1N5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806633.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01906"/>
    <dbReference type="EnsemblBacteria" id="ACU08348">
        <property type="protein sequence ID" value="ACU08348"/>
        <property type="gene ID" value="FIC_01906"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01906"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046841_0_0_10"/>
    <dbReference type="OMA" id="FGYLIMM"/>
    <dbReference type="OrthoDB" id="1155696at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="438" mass="49042" checksum="72A0C1082E52958F" modified="2009-09-22" version="1">MKNIFLITKREYLTQVKKKSFIVLTLLAPVLMIGFGVLIAFMFKANESSSTFNVIDKSGIFVGKLESDESVKYVFVPQENERALTSTLKDMSGIEGLLIIPELKNGNFAELEKNSKLLINKKIGFDTKQSVAEDLSKVIRQEKIKTLNISEDQIISLDKNFSLNTQNVVDDKQSDSDLDFGVKSGLSLVLMYAVFMFIIIYGVRVMRSVLEEKNNRVVEIIISSVKPFELMMGKILGVTLVALTQFSVWITMSVAGAIFLNTGFSAMQDQISGSGESAEMIQKFDLRNTASEISGILLDMNFALVIFVFIVFFLLGYIFYSSMYAAIGSAVDNETETQQFTLFAIIPLMIGMYGSFTIMNNPEGPLGFWLSMIPFTSPVAMIARIPFGVPAWQIALSMFLLLISTFLMIYIASKIYRVGILMYGNKASAKEIWKWMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q1</accession>
    <name>C6X1Q1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01922"/>
    <dbReference type="EnsemblBacteria" id="ACU08364">
        <property type="protein sequence ID" value="ACU08364"/>
        <property type="gene ID" value="FIC_01922"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01922"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046663_0_0_10"/>
    <dbReference type="OMA" id="NEISFWA"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="373" mass="43246" checksum="6C70F8C4499515C0" modified="2009-09-22" version="1">MQQEPLFKSYFMGGFECADHLNRHGERVNLLKETQHDQRAEEDFQLLADLDIYTVREGICWSEVEKRPFEYDFSEVLQRMRAAEKKGMQVIWDLIHFGYPDGLFPTHPQFAHRFVSLCRAFAEFYKQNSSEQLLVVPVNEISFLSWYSGENRGTVPYAIHNGWDIKYHLCKVAILGIEVLKEILPDCKIVMVEPLVKIHCNGDEPEHLIRKNEYQFEAMDIIGGRLCPELGGKDEYLEILGFNYYWNCQWKGEGESLCWPGPDRTPLHELLRSAYERYRKPVFLSETGHFGEGRGEWLNEIAAECLTAQEHGVDFHGICLYPVTDRPDWDNLALYHNSGLFDLDLSGNRIPDNGYIAALKNQQEQLASSFTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T0</accession>
    <name>C6X1T0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein containing immunoglobulin-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01951"/>
    <dbReference type="EnsemblBacteria" id="ACU08393">
        <property type="protein sequence ID" value="ACU08393"/>
        <property type="gene ID" value="FIC_01951"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01951"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232899_0_0_10"/>
    <dbReference type="OMA" id="IDYHYKN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044023">
        <property type="entry name" value="Ig_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045829">
        <property type="entry name" value="PKD_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19081">
        <property type="entry name" value="Ig_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19408">
        <property type="entry name" value="PKD_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973603" evidence="1">
        <location>
            <begin position="33"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_7" evidence="2">
        <location>
            <begin position="797"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="PKD_6" evidence="3">
        <location>
            <begin position="871"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="PKD_6" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="2065" mass="213849" checksum="B67E696D7CB57639" modified="2009-09-22" version="1">METQTHMIKKITFYRKSWILMLMFLSLTFADAATYYSRQSGNWNANTTWSTSSNGAALGVNVVLLATDSFVIEAGNVVTVTATTSCASVGFSGTNATLTVNSILTVNGALTVYSGSSNDSSALITGSGILNVTNIFIGTDVNLTATKTTILTSQINKINAGQNIEIYNNSNTSSLIRRFNNAKFELGNGIVDINGQIKTINEHGSNNSTFTLASGNQSGTLLLGNASPFAFSSTGENTLNLNGTTSTVNYDGADQNVYGSTYRNLITSGSGIKSLAGPITVNKDLYISNGTKLIDFEYQIVGNDAGGILTVEDNAMLVLGKGFDYPTPVPPLDLTHNSKVTYFPTLYKKANIKLNEGSIVQYIDWITTGPTQFISTEPDYYHLESQFPGKKTVQSGVLNINGNFSTGSHVDLSTYSPTVNLKGDFFPGATPATVSMTNTTFNIGGNFINDISSGGSLIPGTGTVVFNGAGAQSISGTGFVPTAFYKLNVNNTGGGVSLGIIGTNDDVTVTNTLTLTRGILTTSTTNLLNVTNTAVAAITGGSSASFINGPVKWTTAINAEYRFPVGKGSTHLPFALKTNSTSATPSQVEAFTGSTAGSPNFLIPTVPKTIGSISTTEYWSLSGGTYTASTISLSRPSAISPFDVIAGSGTVNGTYDGLGGTVGDTGITNSSVIGNYRFFTLARKNGIRIDNMSATSLCAGYPIEVPFKITHSYIEENVFKAQLSDASGSFATSTEIGQKKLTLTGVTDALSRSTITSVIPANTPAGSKYRIRVVSSVPAVMGEDNGVDLTVTSTPAPTGPPSQIFCSNQNPTVSNLSATGTVIKWYAAASGGSPLPTTTVLVNGTKYYASQTLNGCESVGRFEVTATVHSLPAVPGVITGSANQCAGNTGQVYSIAPVANATGYTWTVPTGWSITGGLNTTSITVTVGTNAGNISVNAVNSCGTGYASGEGSGYKYITVSPPTVAGTVTPANTVVCGTSNSTNLNLSGNVGAIVRWESSLDNFSGGTITAIANTGSPFTAQNVTVDKYYRAVIQSGGCTLLYSNSAKITHLDNVATPGAISGSDTQCAGSTQIFSVDPVANGTSYTWTVNTASGWSILSGQGTNSITVKIGTSSANVSVNATNSCSTGYGPYKWVTVTPNLPASVSISANSGTTICAGSQVTFTATPINGGTAPSFQWKVNGSNVGSNSATFTTTALASGDKVTAVLTSNAGPCATGSPATSNELVMSVNPRLTASVSIAASANNICAGSTVTFTATPTNGGTSPTYQWRKGGTNITGAINATYTTTSLANNDAITVVMTSNATSCLAGSPTISNAITMVVNPNLPASVRIGATATTICSGANVTFTVTPTNGGLAPSYQWKVNGNPVGANSATFASSTLVNGDEVTVTLTSNATPCLTGSPVTSNAITMVVNPANTVTLSSLPNTDNQQICAATAISPITYETTGANGIANNGVSTGVNGLPAGVTALWNNNKITISGTPTVTGTFNYSIPLSGGCGDKKATGVIKVGLTSVYSASGWSSEGIPQNNGLSVRFYSDYNTSAGSVYACDCTVSASKKLTIAPNTSLTVVNNFTNNGSVLVQSEGNLVQINNTPSPANSGNIISEREFKIGADRVQYNYLGTPVAFESGQSFKTVFPGTTNGTVLYHNQTTNTFSTSSGANVPGRGSAVKEPPVTTVLTDGKTTAQFKGTPQNGEITLAVANKNIDVTTFGYNLMGNPYASNIDLRKLYDINGGKTDGVQVESPNISPTFYFWDNNKNTIFQQQGSSYGGQSYAIFNVLTGPEGTGTAAGSLNNGTVVGAKRPTKIVKVGQGFMTRSLQTAYNFKFDNSIRTAEGSAVDFLGKTATSIPTDRYWLQMTAPSGITSTIAIVHYGGGNDAFGAEDSRTMGGSDALFSMVGTEKSAINGRTSFGDTDKIPLGSSHFVSGNYRIKIDTTEGIFANGQNIYLKDKQTGIVTNLSEGDYTFAANAGESTGRFEIIYKPEAVLATDSAVKEELQVYRDGTNFVVKAQRTNIDDVEVYDLSGRLLQKLKPKSTTAVIDSGLMVNGVYVLKINHNDKITVKKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W8</accession>
    <name>C6X1W8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phenylacetic acid degradation protein PaaN, ring-opening aldehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01989"/>
    <dbReference type="EnsemblBacteria" id="ACU08431">
        <property type="protein sequence ID" value="ACU08431"/>
        <property type="gene ID" value="FIC_01989"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01989"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025047_0_0_10"/>
    <dbReference type="OMA" id="DTFYAHM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011966">
        <property type="entry name" value="PaaN-DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02278">
        <property type="entry name" value="PaaN-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="11"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="4">
        <location>
            <begin position="537"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="829" mass="92131" checksum="B451F7320A1D6A67" modified="2009-09-22" version="1">MKLKNYIYGQWSEGSGEEIPLYNAVNGELVAISDTGGIDYQQALDYGRTVGYKNLSSMTFYDRGEMLKKVALYLLERKKKYYELSYKTGATHADSWVDIEGGFGTFFTYSGLAKRMLPNTPFWVDGDTQKISANGTFIGTHILTPSEGISVQINAYNFPVWGMMEKLSTSLLAGVPSIVKPATPGSYLTNAVFTDMIESGILPEGAIQLVCGEPGNMLDYVQDGDSVLFTGSARTGKKLKSLPSVSTNAVRFNMEADSLNCSILGLDAKPGTPEFDLFIKEVRNEITTKAGQKCTAIRRIMVPENLVDEVQNALGKALDQTKIGNPLNRETRMGSLVGKQQYEEVLKNVNLLKAETELIYDGQHELLDASYESGSFMSPKIFYNDKPFEKNISHDVEAFGPVSTLMPYRDAEEAAALAKRGKGSLVGSIVSNDEKFVAETSWKMASQHGRIFVLNRDSAKESTGHGSPLPTLMHGGPGRAGGGEEMGGLNGLHFFLQKTAIQGSPDMLSAITKVYQQGATQNFSDRHPFRKFFEKVEIGDSLETAGRTVTEADIVNFSNVSWDHFYAHTDSTSLNGTIFDKTVAHGYFILSAAAGLFVSGKKGPVIANYGLENASFFKPVYAGDTITVYLTAKEKINKGVKGRNIPSGVVKWLVEVVNQRDEIVCVATILTLVAKQSPFMELNAKEIQKRLNGLTDSTERKFGEMTPQMMVEHLEEVMRNGFSKLDPSDFPEIPAEKMDLLQDWIYTEQKIRPGAKYPMLAEGEMPTLRFKNLAQAKEKLMQTLKEYLIYYRENPDAEHFHPRFGTLNKEMMELFHRKHFTHHFEQFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1X2</accession>
    <name>C6X1X2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01993"/>
    <dbReference type="EnsemblBacteria" id="ACU08435">
        <property type="protein sequence ID" value="ACU08435"/>
        <property type="gene ID" value="FIC_01993"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01993"/>
    <dbReference type="HOGENOM" id="CLU_1989350_0_0_10"/>
    <dbReference type="OMA" id="IMTKNDS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="13741" checksum="F4B575155E959626" modified="2009-09-22" version="1">MIDSNIKIMKKVVLVASAILFSAVQSCDKKEGNKSVIAAENASDTNRDEKTERYVAEDGSSALVSFITKDNEKSISVRSNNKTITAPWKSEGVYSNYDFEIMTKNDSVTITQGNNVITLKKARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X205</accession>
    <name>C6X205_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02026"/>
    <dbReference type="EnsemblBacteria" id="ACU08468">
        <property type="protein sequence ID" value="ACU08468"/>
        <property type="gene ID" value="FIC_02026"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02026"/>
    <dbReference type="HOGENOM" id="CLU_3356321_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="36" mass="4120" checksum="EEB4E2C76612061C" modified="2009-09-22" version="1">MVAEPCEGTKKDCNGKRDPNFEEAVMLLLQKKIINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X223</accession>
    <name>C6X223_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmE2</name>
        <name evidence="5" type="ordered locus">FIC_02044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806770.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02044"/>
    <dbReference type="EnsemblBacteria" id="ACU08486">
        <property type="protein sequence ID" value="ACU08486"/>
        <property type="gene ID" value="FIC_02044"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02044"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_2_2_10"/>
    <dbReference type="OMA" id="FKDMSND"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="83" mass="9610" checksum="D7C27221775743E5" modified="2009-09-22" version="1">MKNGIHPENYRLVVFKDMSNDETFVCKSTADTKDTIEYEGETYPLVKMEISSTSHPFYTGKVKLVDTAGRVDKFMNKYKKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X246</accession>
    <name>C6X246_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">FIC_02072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806793.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02072"/>
    <dbReference type="EnsemblBacteria" id="ACU08509">
        <property type="protein sequence ID" value="ACU08509"/>
        <property type="gene ID" value="FIC_02072"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02072"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_10"/>
    <dbReference type="OMA" id="EHEWLSG"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="13568" checksum="E752363E4F3B02F3" modified="2009-09-22" version="1">MNTPSELKYTKDHEWVRIDGNVATIGITDFAQGELGDIVFVDVDTVDDELSAGDVFGSVEAVKTVSDLFLPVSGTVVELNSELESQPELLNSDPYGKGWIIKLEIGDDADTSELITAEQYQESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X283</accession>
    <name>C6X283_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806830.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02109"/>
    <dbReference type="EnsemblBacteria" id="ACU08546">
        <property type="protein sequence ID" value="ACU08546"/>
        <property type="gene ID" value="FIC_02109"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02109"/>
    <dbReference type="eggNOG" id="COG4314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108823_3_0_10"/>
    <dbReference type="OMA" id="YDSKDWV"/>
    <dbReference type="OrthoDB" id="1678497at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008719">
        <property type="entry name" value="N2O_reductase_NosL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05573">
        <property type="entry name" value="NosL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="136" mass="14420" checksum="ACB95540A0322C2B" modified="2009-09-22" version="1">MNILKNTFAVGSVIAMLSCQSSGPKDIALGKDQCDNCRMTISALGYAAELVTDKGRAYKFDDIMCMNMYEGSNPDQAKNAKLYVVDYPTGKFIEKSKATFIKGGSIKSPMGGNTQAYQNKAAAQKAAAALGAGLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A1</accession>
    <name>C6X2A1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02128"/>
    <dbReference type="EnsemblBacteria" id="ACU08564">
        <property type="protein sequence ID" value="ACU08564"/>
        <property type="gene ID" value="FIC_02128"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02128"/>
    <dbReference type="eggNOG" id="ENOG502ZB0E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027407_0_0_10"/>
    <dbReference type="OMA" id="WLYINEA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970556" evidence="1">
        <location>
            <begin position="20"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="666" mass="71479" checksum="9B930C5AB9ED3624" modified="2009-09-22" version="1">MKKNLLMLSVIAVSFSATAQVSFTVNPNAVFYVGENTLVYHGGGLQTKGNAVYDVRGNVMIEGNSTDVFRTLDAAGTTGKTDGGNFILRLNNPANHSAALNPSTYGQLYINGLTQGANVTAVVDKEYRTAKHGTYQQIALPFYNKLISSLSGSASAIGTLGKTFTNTRYSKNEVLTWNNATVVSQNLNVSSATPKSTTYYMLGSNGLDSGNPPASMPANAPALNGTVYTLKGIPFTNGVTEKLINAANGINFGPTGNATNAYNERYNSYLQDDWDYLVNPSNPWATPTFGRNMYQFGNPYLTNLDLGLIGIVETASPGDNNAISSIQGIRYDPGSVVSSTAGTYSVGAKFVNFTMTGSPGAPVPVGDVGLIIKPMQTFVIKLRNNNAELGTDRTLSFDRLRRFKNTPRADGTNYSVNAKGASATVKQLGILALNDAGKEISRTYYAVYPSAISGHTSQPTTQSVLGSANIIGTYEEDALNGGMDMSLSNSYWLYINEANETDFAGKAIPLALYSNDIKSLKFEIRENTELLPDGIHNLSTGTGFYFKAPNGALTEIVQNQVVPVAGDQYNLYFGKPEIVLGTDGGAKPSRTMVVYNRMADNYVVRFDSNWNKADVKVYDMSGKLVLAQKGVSTNEDFVLDLSKADAAYLVTAVSETGEKMSSKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A3</accession>
    <name>C6X2A3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806850.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02130"/>
    <dbReference type="EnsemblBacteria" id="ACU08566">
        <property type="protein sequence ID" value="ACU08566"/>
        <property type="gene ID" value="FIC_02130"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02130"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_1_10"/>
    <dbReference type="OMA" id="VGLEVPH"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="129" mass="14552" checksum="1B31FCD96E524FF6" modified="2009-09-22" version="1">MGSVFSKIIAGEIPSYKIAEDKAHLAFLDAMPLVKGHTLVIPKQETDLIFDLEAEDFKNLWAFAHEVAQKLKVAYPDKRIAVAVVGLEVPHAHIHLIPISKTEDMNFKNPRLQLTESEYFEIQDVIINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A8</accession>
    <name>C6X2A8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806855.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02135"/>
    <dbReference type="EnsemblBacteria" id="ACU08571">
        <property type="protein sequence ID" value="ACU08571"/>
        <property type="gene ID" value="FIC_02135"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02135"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_10"/>
    <dbReference type="OMA" id="GHMGMFE"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="260" mass="29108" checksum="2F62E2E5F841B197" modified="2009-09-22" version="1">MLNYEISGTGREPLVLLHGFMENLMIWNEMEEFLSTNFQLIKIDLPGHGLSKVYAETHTMELMANEVKKVTDKLKLKNFHLLGHSMGGYVALSFAEKFSADLKSITLFFSSFLEDDADKKEQRKKSLRIIKEAYPAYVNAGIPNLFNGNEKDILEGKIQLAKEIALSTKTDGVLAAVKGMIERTDKSTLLESFEGKVLVLAGKHDNAVKTENVLSKLPEKTNIKSYLLDCGHNGHWEKPAVCAAIINTELLHNLPKNLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C1</accession>
    <name>C6X2C1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806868.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02148"/>
    <dbReference type="EnsemblBacteria" id="ACU08584">
        <property type="protein sequence ID" value="ACU08584"/>
        <property type="gene ID" value="FIC_02148"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02148"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028014_5_0_10"/>
    <dbReference type="OMA" id="AICPMLS"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="385" mass="44563" checksum="20D71951753EECD3" modified="2009-09-22" version="1">MMPKILYFMPDNPLSGRAGNLVRAKVMLDFFEEHHADLQVDFFSVKDWADWTDHDVTHFETVYPHIKLLLKNRKIPSTNPLQRIFLYKIPNFFYKLFRGTSVDISGFRLKRSMKRLIKKEKYDIVVISYAVWGALIENLKHKPYLINDTHDFISAQSSKKTAIVGKLVQSEINILKKFDELWTYSVEEQYIFEQFTQRKVKLLPVSFPQHPLLPVQTKKFDLIFVGSQNPHNVMGIKWFIDKVFPLLPGLKVHIIGKVCENVQCDNPNVVTEGMVEDLSYHYNNARIAICPMLSGTGVKIKVLEALSYNLPVVTNRRGVDGLVNKSGSGCLVTNDPQKFAGYIRQLMTDDILYDKVRSEGRNYFTQNHLPQLEKAFMNTTFLHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D0</accession>
    <name>C6X2D0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase alpha chain</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806877.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02157"/>
    <dbReference type="EnsemblBacteria" id="ACU08593">
        <property type="protein sequence ID" value="ACU08593"/>
        <property type="gene ID" value="FIC_02157"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02157"/>
    <dbReference type="eggNOG" id="COG0307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_2_0_10"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="1276859at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="198" mass="21892" checksum="9B986D8E30E6751C" modified="2009-09-22" version="1">MFTGIIEATATVEKIETIGENINFTLSCPFTDELKIDQSLAHNGCCLTVVETSDKTYRVTAVAETLQKTNLGRWTAGTEVNLERCLKMDGRLDGHMVQGHVDQTATVERIEDRDGSFLVTIRHNETADFMTVPQGSITVNGISLTVAASNPGEFSVAIIPYTWEFTNMKKIKVGDLVNLEFDIIGKYVTKLMKKNAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F6</accession>
    <name>C6X2F6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YadS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806903.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02183"/>
    <dbReference type="EnsemblBacteria" id="ACU08619">
        <property type="protein sequence ID" value="ACU08619"/>
        <property type="gene ID" value="FIC_02183"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02183"/>
    <dbReference type="eggNOG" id="COG2860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064906_2_1_10"/>
    <dbReference type="OMA" id="RAPRAWN"/>
    <dbReference type="OrthoDB" id="1665397at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="211" mass="23526" checksum="E7A93D7ECFE704A4" modified="2009-09-22" version="1">MVHENLNLAIELLGTVAFAMSGSFAAMQKRLDPFGVLIIAFITSVGGGTVRDLLLDVPVFWMRDLVMCSVIFITCLLSMIFKSMENKFKVTLFIFDSFGLGLFTIVGIQKGLNADLHPLICLTLGTITGCFGGIIRDMLLTRIPLIFRKEIYATACIVGGTVFLLLIKYSSLSYAFIQIFTILLIVAIRTLAVKYHWQMPKFYGNEQNSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K6</accession>
    <name>C6X2K6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806953.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02236"/>
    <dbReference type="EnsemblBacteria" id="ACU08669">
        <property type="protein sequence ID" value="ACU08669"/>
        <property type="gene ID" value="FIC_02236"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02236"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_4_5_10"/>
    <dbReference type="OMA" id="IVLHQTY"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="95"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="428" mass="48431" checksum="A6E04F89033ED8FB" modified="2009-09-22" version="1">MISSSISVKKYFLFIGILLFSFSFAQKKFTIVLDAGHGGSDHGANRYYSELGTLREKDVTLSVVLKVGRMLEKNKDFKVIYTRKVDEFPSLSERTTLANRSKADLFISVHCNASTKTSPYGTETFVQGPDQNKTNLEVAKAENDVIFLDEKDREMFASYDPKSPESLIALKIQQSKYLESSLLFGSFVEDNFVKKDKRFSRGVKQQNLHVLRLNAMPSVLIETGFISNYEDAVYLESDKGQTEIAESIYNAVISYKKALERNTGTVAPREQPKPEEKPLKNDFRILLMSTPTKYNSSDPALKGLNYVLPIKENGMYKYYYGTTNMASIRDNNLKTAKDAGFKNATSISFVPNQKLGMGYYTLELAVSTQKLSSNSYMLSTLKDVTRVKENGKFYYTYGRFTTLEEAVKMQKTLEDKGIKNSVIQKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L0</accession>
    <name>C6X2L0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine protease, HtrA/DegQ/DegS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806957.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02240"/>
    <dbReference type="EnsemblBacteria" id="ACU08673">
        <property type="protein sequence ID" value="ACU08673"/>
        <property type="gene ID" value="FIC_02240"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02240"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_10"/>
    <dbReference type="OMA" id="IIGINRQ"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="302"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="504" mass="54152" checksum="E1AF0F584A202EC2" modified="2009-09-22" version="1">MKMDILKKLIPYAFVGVVSGATTFGAINYFNVHQTDSQFSYFEPKNSDAKYASFNTAGIGEDFVKASKSTVPAVVSIKNYADRTTRRSEQDMFDLFFGNPFGGQPKQQQQPPQNMPSGMGSGVIISPDGYIISNNHVIAGANKLEVVLSNKKSYVATLVGTDPTTDIALLKIEEKGLPYLNFANSDNVEVGQWVLAVGNPMGLNSTVTAGIISAKGRSIDLLSQQSRTPIESFIQTDAAINPGNSGGALVNTNGELIGINSAISSKTGYYEGYGFAVPSNLARKVVEDIKQFGLVQRGFLGVNTLDLSDTRQVGLYNQQNKTNIKAGDGVYLTAVVAKGGAEAAGLRTGDIITKVDNTTISSYYDLSFAVGSRRPGDKVAVTYLRNGKTNTVNVTLRDEKGGTSFRSKADLTVSEKIGSDFEPLSDRFKTDYGLNSGVIAKNVAPGSEMAKIGVVDNYIIVEINGKPVNSQKDVDKVLQGYNGNVQVKYVDEYGRITTRGFKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L2</accession>
    <name>C6X2L2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cutC</name>
        <name evidence="3" type="ordered locus">FIC_02242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08675">
        <property type="protein sequence ID" value="ACU08675"/>
        <property type="gene ID" value="FIC_02242"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02242"/>
    <dbReference type="eggNOG" id="COG3142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050555_3_2_10"/>
    <dbReference type="OMA" id="FHRAFDQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="220" mass="24288" checksum="29B0F73F5F76CA43" modified="2009-09-22" version="1">MLEIACFEITSAETALKSMADRIEFCAEFELGGTTPDFYEFMHLKRTYQKPVYVMIRPKGGAFYYSESEFIEMKNSIITFGEAGADGFVFGILSPNNEIDEAKNAELITLAGGIPCTFHRAFDHTADLENSVEILIKLGFKAVLTSGGKKSVMEGKEQLKNLVAGYSDRIDILIGGGVRSDNVAELKEFTGGKYFHSSAIPKYDTFGSEAEIKKIKKLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W6</accession>
    <name>C6X2W6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">FIC_02346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02346"/>
    <dbReference type="EnsemblBacteria" id="ACU08779">
        <property type="protein sequence ID" value="ACU08779"/>
        <property type="gene ID" value="FIC_02346"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02346"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_3_10"/>
    <dbReference type="OMA" id="NKKAFCY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="591"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="761"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1138" mass="129803" checksum="4F2F971C2DEC79B1" modified="2009-09-22" version="1">MMQLKTIKETFLPDMLQNEFGKEIFENIDQFRHLSVKGSAGSAPSIFAAELFVTRKKTVLFLIEDKEDALYATAEMEDLLGKENVLYFPATHLAPYQIEKTQNANLVLRTDVLNKLNASKKPKVIIAPFSSLSEKVLRKEDFKAISHRIKVGESLDFDFTGELLQQFNFQLTDFVSEPGEFSVRGGIVDVFSYSNEEPYRISFFGNEIESIKTFNIETQLTNGKVNEFQLVSNMNYAVSGSKVSLLGLLPNDSFVVSVNAILATRKISDFFTKADEYYEALNKDIKHQPPAELFVSEEEFLKDIAAFKHIDFTLDTLKTSQADTLLIQLNQTQQPGFHKNFELLLEDLVEKRNANFDIWISFSTEKQKERLEAIFKEISTPQEMISDSEDLPVFQQKAFFKSFKSELHEGFVDADHKISVYTDHQIFDRYQRFKAKNTFAKSEQLTLKDLMQMKVGDYITHIDHGIGKFMGLVKVNNNGKVQECFKLTYKNGDLLYVSIHSLHKISKYNGPDGREIVLSKLGSPAWKTLKQKTKAKVKQIAFDLIRLYAKRKTAKGFAFTPDSYLQNELEASFIYEDTPDQEKATLDVKTDMEKETVMDRLICGDVGFGKTEIAVRAAFKAATDGKQVAILVPTTILAFQHYRSFKERLKDFPVNISYMNRFRTAKQKSETLKGLAEGKIDIVIGTHQLVSSTVKFKDLGLLIIDEEHKFGVAVKDKLKTLKNNIDTLTLTATPIPRTLQFSLMAARDLSVIKTPPPNRQPVETSIVGFSEEIIRDAISYEIQRDGQVYFINNRIENLKDIAGLIQRLVPDAKVITGHGQMEGKQLERNVLDFMEGKYDVLVSTTIVESGVDVPNANTMFINDAQRFGMADLHQMRGRVGRSNRKAFCYLITPPFDMMTSDARKRLEAIEQFSDLGSGFQIAMKDLEIRGAGDLLGGEQSGFINEMGFDTYQKIMQEALEELQNDEEFGELFENEEDRKKLFKSTKEVNIDTDLELMLPDVYVQSIEERLSLYQKLAEIQNRGDLRKFENELNDRFGALPPEAKNLLKSVELKWIAAEIGFDKIVVKNGVFLGYFPPNPQDKFYQSEKFRNIIAYLHQNPSEATLKEKVNKEGNQLMMRKENVQNVDEVNRVLERIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X305</accession>
    <name>C6X305_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidase, M28 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807102.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02385"/>
    <dbReference type="EnsemblBacteria" id="ACU08818">
        <property type="protein sequence ID" value="ACU08818"/>
        <property type="gene ID" value="FIC_02385"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02385"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_0_0_10"/>
    <dbReference type="OMA" id="HYHKVGD"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="85"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="308" mass="34126" checksum="77319386AB0EE4C5" modified="2009-09-22" version="1">MNNYLKLFFLLCTSTVYSQEVSRQSVVNTLSVLASDQMKGREIGTPQNDSAAVFIAKRFEENNLDYCVGTSFLVPFEYKGKTAYNVCGIKKGKSDKSLAYSAHFDHIGSNGKGPDPIFNGADDNASGVSLMIGLSEYFKTSAPEFSMIFMAFNGEEKGMKGSKAIAEEVQLQKYFNNTQALFNFEMVATVSQFGANAMYMTGDTFSDLDELMNTAAADQFKIHPDPYTGQQLFYRSDNVVFAKKGIIAHSFSTVDMTTAKHYHQANDDLAVVNFDNLTLMINSLGKTISTLKPSDFSPKYNETVNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X349</accession>
    <name>C6X349_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ordered locus">FIC_02429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02429"/>
    <dbReference type="EnsemblBacteria" id="ACU08862">
        <property type="protein sequence ID" value="ACU08862"/>
        <property type="gene ID" value="FIC_02429"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02429"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_10"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="19"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="258"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="282"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="382" mass="43285" checksum="8D24D1C24ED69574" modified="2009-09-22" version="1">MKDNITTPFFEINKSSTGKARAGTVTTDHGTIQTPIFMPVGTVASVKTVHQRELKDDIKAQIILGNTYHLNLRPGMDVMEAAGGLHKFMNWDLPILTDSGGYQVFSLTKSRKLNEEGVKFKSHIDGSTHFISPEKSMEIQRQIGADIFMAFDECTPYPCEYNLAKTSMEMTHRWLRRCIEWTEANPEIYGHKQHLFPIVQGSTYSDLRKASAEFISEQNAVGNAIGGLSVGEPEDEMYRITDEVTDILPKDKPRYLMGVGTPWNILESIGLGIDMMDCVMPTRNARNGMLFTWNGVMNMKNEKWKADFSPLDEFGTSYVDSAYSKAYVRHLFVAKEYLSKQIASVHNLAFYLDLVRVARQHIVAGDFYDWKESVVPVLKQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X357</accession>
    <name>C6X357_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807154.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02437"/>
    <dbReference type="EnsemblBacteria" id="ACU08870">
        <property type="protein sequence ID" value="ACU08870"/>
        <property type="gene ID" value="FIC_02437"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02437"/>
    <dbReference type="eggNOG" id="ENOG5031KC7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1473112_0_0_10"/>
    <dbReference type="OMA" id="WEFVSDS"/>
    <dbReference type="OrthoDB" id="1965152at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="183" mass="20528" checksum="421A8E24995F7917" modified="2009-09-22" version="1">MRNLLRYSLLFGLLLGCTDDQKEQNLLQREQKLSEKETKFEAKEAEYKSLLALRDSLENSVPATPAVEELPAEILGKWSGKMICTESSCTDHVIGDQRTDVWEFFANGLKMTNKTGGERDFTANIVGDELKLVSEESSNITNRSEITLSLTDLQNGRMKGTRAFIGKNDCIAKFSVELEKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X381</accession>
    <name>C6X381_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="8" type="ordered locus">FIC_02461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807178.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02461"/>
    <dbReference type="EnsemblBacteria" id="ACU08894">
        <property type="protein sequence ID" value="ACU08894"/>
        <property type="gene ID" value="FIC_02461"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02461"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_5_1_10"/>
    <dbReference type="OMA" id="HMYERGI"/>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="214"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="28"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="606" mass="66579" checksum="9E14AAA7BD97F3D1" modified="2009-09-22" version="1">MENMNTPGFSFDLPKGNSSIIKVIGVGGGGNNALKHMYERGIHGVDFVICNTDAQTLDNNPVSNKVQLGVTITEGLGAGADPEVGEKAAIESIEEIKAAMGQNTKMVFITAGMGGGTGTGAAPVIAKVAKDMGILTVGIVTVPFSFEGKRRLEQADLGLDKLRNNVDSLIVINNDKLRQQYGNLGFKSGFSKADEVLTNAAKGMAEVITGYFDVNIDFRDAKSVLANSGTALMSNGIASGENKAEEAVKKALDSPLLNDNKITGARNVLLLIRSGSEEVTMDEIGVIMDHIQKEAGNTADIIFGVGTDEELGDAVSVLVIATGFAKDHHKHSGVSEKINFKLTDEMSAAAPQQSPFTHKSSREEIKRENFNRDGLFVLDDEEDCPVQEFPVRTSEPKASTKMSLTPNEFFSLTDTELPEQTFNINTPSREIDLFSFDDSNAQEPESQSFKFEVETPKETPNKTLFQADEPMEFSFFVNEPIEEPKAETPQPKVIINEKPVLKTETKVETAEKSETPKFEVEDDFTFVSKPTSNEKILERRNKLKEFNSRYQITETENEFETIPAYRRKNIAVEGTNASEHKINSYLAEDNGRMQVRENRFLNKDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6X385</accession>
    <name>C6X385_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="16" type="ordered locus">FIC_02465</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807182.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02465"/>
    <dbReference type="EnsemblBacteria" id="ACU08898">
        <property type="protein sequence ID" value="ACU08898"/>
        <property type="gene ID" value="FIC_02465"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02465"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_10"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="15">
        <location>
            <begin position="116"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="14">
        <location>
            <begin position="319"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="118"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU08898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="461" mass="51436" checksum="52A9C846583820E5" modified="2009-09-22" version="1">MKTLETYQNLFFVGVGGIGMSALARYFHASGKNVLGYDKSRTKLTSVLVSEGIDVVFEDVIDQKINGLTPENTLVIYTPAIKELGILKHFTDLGFRVLKRAQVLGMITHDTNSIAVAGTHGKTTTSSLVAHLCREAELPFSAFLGGIAENFKSNFLFNGDDISVVEADEYDRSFLQLSPDWAIITSIDADHLDIYGDTATIEKGFRDFAELVPEDTQLFVRKGIDIGRPARTYAANEKADFYSDNIRETGDKILFDFHDESGDIYLFEWEIPGIHNVENATAAIALLHTFGVSYKTLQRGISGFKGIKRRYTKHSFSTGKIYIDDYAHHPTELNAVIGSLKTFYPDKKLLVVFQPHLFSRTRDFADGFADSLEKADDLILLDIYPARELQKNYEGVTSQWLSEKIKTENKEVAALEDAFAKIKEKNFDILLTVGAGNIDILSDGIVEWLATESDEKQPSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X390</accession>
    <name>C6X390_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="12" type="ordered locus">FIC_02470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02470"/>
    <dbReference type="EnsemblBacteria" id="ACU08903">
        <property type="protein sequence ID" value="ACU08903"/>
        <property type="gene ID" value="FIC_02470"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02470"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_10"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="111"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="327"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="404"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="404"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="488" mass="54199" checksum="CFB2CA118CA8C2DE" modified="2009-09-22" version="1">MIMNLEDLIKKVQILDILGDRNRDISAIVSDSRKAVAGSLYVAVKGTVADGHSFIDAAVAQGAAAVVCNAFPENIDTDITYIKVEDSAKALGQLASGFFGNPSEKLNLIGITGTNGKTSVTTILYDLFKYLGFKSALISTVEYRIADKVLPSTHTTPDVITLNKILAEAVEAGCEYAFMEVSSHGIHQKRTERLHFKIAGFTNISHDHLDYHKTFSEYLKTKQSFFDGLNPDAVAITNLDDKNGKIMLQNTKATRKSYALKTMADYHGKTTETDFNGMLLNFDGKEFWTTLTGRFNVYNLLLAYAIALECGFHSDDVLKAISLLKRVKGRFETLKSDGGIFFVIDYAHTPDALDNILDSINEIRTKNERLITVFGCGGERDQTKRPEMGKISTRKSTLTIITSDNPRSENPGDIIKEIEAGVEPQYYSKYTSIPDRRDAIKMAIKFAEPKDIVLVAGKGHENYQEINGQKVHFDDKETIVELTRLMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A2</accession>
    <name>C6X3A2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutL</name>
        <name evidence="6" type="ordered locus">FIC_02482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02482"/>
    <dbReference type="EnsemblBacteria" id="ACU08915">
        <property type="protein sequence ID" value="ACU08915"/>
        <property type="gene ID" value="FIC_02482"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02482"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_0_10"/>
    <dbReference type="OMA" id="RLPNGYW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="5">
        <location>
            <begin position="215"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="592" mass="68098" checksum="125C9332681E48F7" modified="2009-09-22" version="1">MCLNKLMSDIIKLLPDHVANQIAAGEVVQRPASIVKELMENAIDAHATKVELIIRDAGKNLIQVVDNGSGMSDTDARLAFERHATSKINCTEDIFRISTKGFRGEALASIAAVAQVELRTKTKDAVTGTNIYIEGGGFQFQEPIQTAEGSNFLVKNLFYNVPARRKFLKNNNVEFRHIIDEFQRVALAHENVDFELFHNDDIIFRLRKSGLLQRIVEVFGRKLHPLLIPIKEDLGWVKLSGFVAKPEGAKKVRGEQFFFVNGRYFKSPYFNKAVQEAFEGLLLPGYIPTFFLFLELDPEKVDVNIHPQKTEVKFEDENLIFALVRSTIKKSLGIYNVAPSLDFEKDVTMDAFVHQKNGGNVYHAPDVTVDRDYNPFLEERASAGDHAAMTEIYQQSASAKPSKINLFEEEDFDEDLMRLPNGYWLFNRNGKTLMLDLGRMHRLIVSERNAKKKKNVEQHTLLFSLEYHMNETEKNKFRSIKKYLPSLGFEMVIANDNVLRIDAVPEGLKESQVMKFMEQLFDILEYRTEDEFLNFYNNQWVKIQSRSRFDFLYKTDAEHLIKDFTALGFPEYLPSGKRCFIELPLEDLKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B6</accession>
    <name>C6X3B6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="12">FBP aldolase</shortName>
            <ecNumber evidence="5 12">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FIC_02496</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 12"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807213.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02496"/>
    <dbReference type="EnsemblBacteria" id="ACU08929">
        <property type="protein sequence ID" value="ACU08929"/>
        <property type="gene ID" value="FIC_02496"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02496"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_0_0_10"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="10">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="10">
        <location>
            <begin position="283"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="355" mass="38864" checksum="B0E2EC333B62B050" modified="2009-09-22" version="1">MSRRFPAGVATGKLVTEIFDFAKENNFALPAVNVIGSSNVNAVLETAAKLNSPVIIQFSNGGAAYNAGKGLNNDGQKAAIAGAVAGAKHIHTLAEAYGATVILHTDHCAKKLLPWIDGLMDANEEFFAQTGKSLYSSHMLDLSEEPIEENMDISCKYFERMAKMGMTLEIELGVTGGEEDGVDNSGVDSSKLYTQPDEVAYAYERLNAISPNFTIAAAFGNVHGVYKPGNVKLTPKILDNSQKYVQEKFGTAEKPVNFVFHGGSGSTVEEIREAISYGAIKMNIDTDLQFAYAEGIRDYMTQNIEYLRSQIGNPDGEEKPNKKYYDPRVWVRKGEETFITRLVQAFEDLNNVNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D6</accession>
    <name>C6X3D6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807233.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02519"/>
    <dbReference type="EnsemblBacteria" id="ACU08949">
        <property type="protein sequence ID" value="ACU08949"/>
        <property type="gene ID" value="FIC_02519"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02519"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_11_2_10"/>
    <dbReference type="OMA" id="YNAKQQL"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973659" evidence="2">
        <location>
            <begin position="19"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="449" mass="49855" checksum="7724F2434D398797" modified="2009-09-22" version="1">MKRSAAVFLVLLSASTFAQKKWTLQECVNYALENNLTVVQNNLNTKIQEYSLQIAKNQFLPSVSGNISNNASFGQGRDVFGNTNRNDNFSNSASVGADILLFNYGRLEKNVRRTEFEVEASKYDVERIKNDISLQIAQQYLSVLLNREIAKISASALENADRLYRRAKITTEVGTTPQTILAEAEAALSREKQNVKTAEINTNRSLFALAMLLQLEDYKNFDVQNVPVNDVLDAPLFTAEDVIGKAYENQPQIRAAESRIKSAEAQTEVTETAFWPTVSATAGIGSSYFNSLVTNYAGVDINGNPINESGFFRQYKDNFGQQLGLSANIPVFNKGITKLQVEQSKINEDIAKIALQQQKQEVLQNVQQAQFDAESNYAAYLAATDAERSSRLALDFAEKSFEAGRSTIYDLNSARNNFANAQGSVAQAKYNYLFSMKLLNFYAGIPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I1</accession>
    <name>C6X3I1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807278.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02564"/>
    <dbReference type="EnsemblBacteria" id="ACU08994">
        <property type="protein sequence ID" value="ACU08994"/>
        <property type="gene ID" value="FIC_02564"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02564"/>
    <dbReference type="HOGENOM" id="CLU_173284_0_0_10"/>
    <dbReference type="OrthoDB" id="1942353at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025698">
        <property type="entry name" value="2TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13239">
        <property type="entry name" value="2TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="2TM" evidence="2">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="100" mass="11814" checksum="E0F4891042D816AF" modified="2009-09-22" version="1">METYNDENIKYLEARRRMKEIKGFYIHFFIYLLINLFTMMQFLMTAARGTDLKQGVNLYSGVLGGIVIIIHAVSIFLPGIKEWEWKKTRELMKTSNNGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J0</accession>
    <name>C6X3J0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ordered locus">FIC_02573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02573"/>
    <dbReference type="EnsemblBacteria" id="ACU09003">
        <property type="protein sequence ID" value="ACU09003"/>
        <property type="gene ID" value="FIC_02573"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02573"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_4_0_10"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU09003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="244" mass="27420" checksum="3BE0E4EDC5F9CC02" modified="2009-09-22" version="1">MPGILYFVPTPVGNLEDMTFRAVKVLKEVDYILCEDTRTSGFLLKHYEISKPLKSYHLHNEHQTTQKVIEDLKSGQNIAIITDAGTPGISDPGYLLARAGAEEDIEMVCLPGATAFVPALVVSGLPNNEFLFAGFLPQKKGRQTKLKQLAEEKRTIVLYESPHKINTTLEQIKEFFGEETKVSLSREISKKFEETKRGTINELIDFSKSKTLKGEIVLIINNADQDPVHDDDKPSKNKYKNINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L1</accession>
    <name>C6X3L1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusC, outer membrane protein involved in starch binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782146.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00541"/>
    <dbReference type="EnsemblBacteria" id="ACU06999">
        <property type="protein sequence ID" value="ACU06999"/>
        <property type="gene ID" value="FIC_00541"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00541"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OMA" id="ANIKWEQ"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973533" evidence="5">
        <location>
            <begin position="24"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="47"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="327"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="913" mass="100735" checksum="6705A15F9CB84537" modified="2009-09-22" version="1">MRNYTKVLKIAPAFLLAGSILQAQTTDTVRTAEIEQVVLIGYGTQKKEDLTGSISSLTAKDFNVGSTSADQLIQGKAAGVTITGNGGNPGAGSTIRIRGGASLTASNDPLIVIDGIPMDYSGISGAANALALINPNDIESFSILKDASSAAIYGNRASNGVILITTKKGSSGRLKVDFSTMASVSTRMGDQKVLGADAFREYVRANATQQKYIDMLGTANTNWQDKIYQDAWGTDNNVAISGGIKGLPYRLSLGYNEQNGLVKTNEFRRTSVGLNLTPKLFDRHLSINANLKGSMTENRFNAGIIGATQLMDPTKPVYDYSAQGSQVGNFYEWFLPNGELNVNATANPLASLEARRDVSTVLRGIASLQLDYKLHFLPDLHFNVNAGYDYQEGTGAVTEYSGYRSTFFNLGTRRDYKQEKTNQLLETFFNYVKTIEAVNTKVDLVAGYSYQKFNNQLPGAFTYNGDPSYDATEPSRDFEENLVLLSFYGRGIFTIADKYILNGSVRRDGSSRFYNGVDLTNNWGTFYAASGAWKIIDEDFLKDSTVFSDLKLRAGWGETGQQEVGGYYNSFASYNVSDATAQYGFGDQFYLMFRPTQYNDKLTWETTETINAGLDFGILNNRITGSVDWFKKYTSQLQARVSVPAGEFSNTNIKNIGQMETDGVEFQLNVNPVKTEDFNWDFSFNAAHYNPKITQLDDVADGYIIPTGGISGGIGNTVQAHMEHQTPYSFLVYQQVYDSAGKPMEGVYVDRNGDGAITESDKYLYKSTTPDATFGFSTRLNYKNWDFSTSLRAVLGNYVYNNFASQSNVQSIATNDYLQNISSVAASYGFKNVQYWSDIFVEDASFLRMDNLSLGYNFGDIFGTSSNLRVYGMAQNVFVITDYSGVDPEIFGNIDNGFYQRPKVYSLGLNFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N5</accession>
    <name>C6X3N5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siderophore (Surfactin) biosynthesis regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00565"/>
    <dbReference type="EnsemblBacteria" id="ACU07023">
        <property type="protein sequence ID" value="ACU07023"/>
        <property type="gene ID" value="FIC_00565"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00565"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104083_2_0_10"/>
    <dbReference type="OMA" id="HNISISH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="116"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="219" mass="26310" checksum="4ECDFBE7958326AE" modified="2009-09-22" version="1">MNNFLQIYELIPAPQNMPLYRDFSDDNATILMWKYDENEELDSEFLLEKENYDKIKDYHPTKLKELLLVRKILKSVLPEHKILYNGRMPYLEPRDYEISITHSFPYAALAISKHKVGIDIEPFNPKILKIQHKFLKDEEAGFIEENKETAYLTVIWSLKESLYKIHHSKYWSLKKHYEVKPFSLDFPFNIMCRVHDEKVSDLFKARVEFFENYCFTVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P5</accession>
    <name>C6X3P5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782180.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00575"/>
    <dbReference type="EnsemblBacteria" id="ACU07033">
        <property type="protein sequence ID" value="ACU07033"/>
        <property type="gene ID" value="FIC_00575"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00575"/>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_6_0_10"/>
    <dbReference type="OMA" id="CINMERR"/>
    <dbReference type="OrthoDB" id="2077602at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="83" mass="9896" checksum="EC83C16637852F76" modified="2009-09-22" version="1">MYFCYILYSKSLDRYYIGHTGENLDERLRKHLSHHHGFTSRAKDWIIVYSETFSDKSAAYKRELEVKSWKSSIKFKKLIDATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P7</accession>
    <name>C6X3P7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Aspartate ammonia-lyase</fullName>
            <shortName evidence="5">Aspartase</shortName>
            <ecNumber evidence="3 5">4.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-aspartate = fumarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16601"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="4.3.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782182.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00580"/>
    <dbReference type="EnsemblBacteria" id="ACU07035">
        <property type="protein sequence ID" value="ACU07035"/>
        <property type="gene ID" value="FIC_00580"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00580"/>
    <dbReference type="eggNOG" id="COG1027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_0_10"/>
    <dbReference type="OMA" id="RIATIWN"/>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006531">
        <property type="term" value="P:aspartate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004708">
        <property type="entry name" value="ApsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00839">
        <property type="entry name" value="aspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="12"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="7">
        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="466" mass="50772" checksum="C426A4FE402FEAB5" modified="2009-09-22" version="1">MENFRHESDLLGTLQVPANAYYGVQTQRAIDNFKISGQYLSSYPHFIAALGMVKKAAAKTNYELGLLQEEMYRNIAAACDELVAGELHDQFPIDMIQGGAGTSVNMNANEVIANRVLEKLGKEKGDYQFCSPNDQINLSQSTNDAYPTAIKLALLHMNADLVEKLRKIIAAFRAKGAEMNDVIKMGRTQLQDAVPMTLGQEFEAFAAILEEDISKLNTNANLFVEINMGATAIGTGINAPLGYAKLCAKNLAQISGYPVVSAPNLVEATSDTGSYVIYSSALKRLAVKLSKICNDLRLLSSGPRAGFFEINLPPMQPGSSIMPGKVNPVIPEVVNQVCYKVIGNDLTVTFAAEAGQLQLNVMEPVLSHSIMESINFLGNAMDTLREKCITGITANKEVCLYMVRHSIGIVTALNPYIGYKNSTEIAKEALETGKSVYNLVLEKGILSQEKLDEILNPANMLKPHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q2</accession>
    <name>C6X3Q2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782187.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00585"/>
    <dbReference type="EnsemblBacteria" id="ACU07040">
        <property type="protein sequence ID" value="ACU07040"/>
        <property type="gene ID" value="FIC_00585"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00585"/>
    <dbReference type="eggNOG" id="ENOG5033653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1701487_0_0_10"/>
    <dbReference type="OrthoDB" id="1702936at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="154" mass="17804" checksum="DFDE5BEFD75B0B71" modified="2009-09-22" version="1">MDKNERLQKYDYEEYTVVTNFETYDDVMAYAQEHNGEVTEVGFTDGSDNPMPNTDGNLMAEGRTFKVGLDKEYKVYYAQDAEFQTMAEDMLEKMKKKENDDSPEDWLADQNIAPGDRIIIVKDGEVNTVTTRERIKFLMRGSLYELAVKVPKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R4</accession>
    <name>C6X3R4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pigmentation and extracellular proteinase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782199.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00597"/>
    <dbReference type="EnsemblBacteria" id="ACU07052">
        <property type="protein sequence ID" value="ACU07052"/>
        <property type="gene ID" value="FIC_00597"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00597"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_6_0_10"/>
    <dbReference type="OMA" id="IVNHGMY"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="374" mass="42185" checksum="5E517634BE930F96" modified="2009-09-22" version="1">MKKIQMVDLQSQYYKIKADVDNAMLGVMNSAAFINGPEVKSFQSELEQYLDVKHVIPCANGTDALQIALMALGLEEGDEVITADFTFAATVEVIHLLKLKSVLVDVDYDTFTIDTDKLKAAITPKTKVIIPVHLFGQCANMEEILKIARQHNLHVIEDNAQAIGAEFTFEDGTTKKSGTMGTIGTTSFFPSKNLGCYGDGGAIFTNDDALAHKMTGIVNHGMYERYYHDEVGVNSRLDSLQATVLRKKLPLLDTYNDARRKAADYYDEVFAEHPNILTPSRAENSTHVFHQYTLRILNGKRNELQQFLTEKEIPAMIYYPVALRKQKAYFQDSDDKDFEKTDRLLNEVISLPMHTELDDEQLKYITDAVLEFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3U0</accession>
    <name>C6X3U0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imm-NTF2-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00623</name>
        <name evidence="3" type="ordered locus">FIC_00628</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">3519-10</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2009-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Christner B.C."/>
                <person name="Raymond J.A."/>
                <person name="Schuster S.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07078">
        <property type="protein sequence ID" value="ACU07078"/>
        <property type="gene ID" value="FIC_00623"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07083">
        <property type="protein sequence ID" value="ACU07083"/>
        <property type="gene ID" value="FIC_00628"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00623"/>
    <dbReference type="KEGG" id="fba:FIC_00628"/>
    <dbReference type="eggNOG" id="ENOG5033DD7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2000527_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028921">
        <property type="entry name" value="NTF2_fold_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15631">
        <property type="entry name" value="Imm-NTF2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Imm-NTF2-2" evidence="1">
        <location>
            <begin position="58"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="124" mass="14181" checksum="198FB76C6806AE09" modified="2009-09-22" version="1">MKKILLMLFVILQFSCNKVSHNKLGIDNAKKELESALKDTTKIAILDNNELLIKEENTAIKVAEPILFEIYGRSKIEGEKPYEAYLIKNYWVINGTVDRYSFGGAFSIIIDARNSKVINVIHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z2</accession>
    <name>C6X3Z2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00675"/>
    <dbReference type="EnsemblBacteria" id="ACU07130">
        <property type="protein sequence ID" value="ACU07130"/>
        <property type="gene ID" value="FIC_00675"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00675"/>
    <dbReference type="eggNOG" id="ENOG5033RPB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1486561_0_0_10"/>
    <dbReference type="OMA" id="SDFKNDF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="181" mass="21764" checksum="9F030D109A52AFCD" modified="2009-09-22" version="1">MSMLKIEELTYNFISQFYDFEKDLVLTNHFHSDWEADILVVNSEGFSHEFEIKYSKSDFKNDFKKNYQNAKTKEKFLKHDKISCGDYICNRFSFLLPMGLIDPKDIPEHCGIIEFDHNPDSWQTRFHEVRKPSQVHDQNFWNLVDKDLMLKMMARNYYFKKLEFKGKWDELILPPKFPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z5</accession>
    <name>C6X3Z5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782279.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00678"/>
    <dbReference type="EnsemblBacteria" id="ACU07133">
        <property type="protein sequence ID" value="ACU07133"/>
        <property type="gene ID" value="FIC_00678"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00678"/>
    <dbReference type="eggNOG" id="ENOG502Z7TF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049598_0_0_10"/>
    <dbReference type="OMA" id="EDMIGGQ"/>
    <dbReference type="OrthoDB" id="624204at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="PTHR37539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="132"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="401" mass="46445" checksum="D47ABEB6FC7E8954" modified="2009-09-22" version="1">MKAKPQFYDAEHFRNFWEKGNGKELLDWAGVSVDINKFDQFARLYHEVDILGDNAVTDTYLKLPYPEASALVHTCSTSDVSENDGAPDSLKKLFTQMQHVPEWFDKDLANVGARLCMRSGTNSLIILRDLSLMGGYDYAYLNKPLIFTGILKKGAVKRLKDTLEFWVGVTRENALEVNSEAYQLIVRTRLMHSYARLKIKKESPDWDYENLGEPINFWDMVATYTGFSLVLMMGLKKLGVQISEKEELGVFHLWKYIGYLLGIPVEYLPENKQQAVEQLYLWSSLQDKGDEDSVQLAQALLEENLENTIYKYPFQRKMLLKLHQSMNWFLLDEDINERLQIPKAGVAAAFPKFIITANKVAQRIFSLDDPEKYQKLVIRGHKDQVQVLEDYIKHTPKDFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X437</accession>
    <name>C6X437_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00720"/>
    <dbReference type="EnsemblBacteria" id="ACU07175">
        <property type="protein sequence ID" value="ACU07175"/>
        <property type="gene ID" value="FIC_00720"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00720"/>
    <dbReference type="eggNOG" id="COG5448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275678_0_0_10"/>
    <dbReference type="OMA" id="IEFNRDW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1012" mass="116538" checksum="32ECF1DD7293734F" modified="2009-09-22" version="1">MDEGVLVKSTRNPVLGDLNSKGSIIRGITFGNNQGQSVQSSMDLQISGKLSKDVSVLASISDHNLPIQADGYTQTLEEFDKIYMQLNIRDKSILKAGHLDLEDNSTYFGRYQRRSMGLQFQTEFGRENKTFVDVSAGVARSEFHRIRFQGVEGNQGPYRLTGKNGEQFITIISGSEQVYIDGILMKRGENQDYVINYNTGEVTFTSFRAILKQNFITISYNYTNRNYTRFLVTGNLRHERERLKTGLSWFMENDNKNAPLSLNLSEDDQQILADAGNNQNLMYAPSGTVSEYDVNKILYRIIESPSGNYYEFSADASQTLYTVAFTYFGQNLGDYQLKQTVNNGRVFEYVGQGLGDYRAVRKLPSPQKTQVFSANAEYLLREGKVGADVSLSNFDVNLFSSKDADENTGYAARVFGYKTITHKQWKGTPRFEYQRISSRFHILDRINNVEFSRDFNLAEEFNQRTQNRLIFSFLNQWENLSFINYRFNYLDEQNFYKGIKNDLDFGWIKGKLSTKGNLSYLDTKATFQGTKFARAGIISEVATAKGSWAIGGSMEHNVKKFNNTQQLDVTSFSWKEVFVQKKISDSTRTRLLARLYFRDNDSVSNNTLENMNHIVGLMAESQLIKTEKATLNALIHYRKFYYQNQDATASFNQDFVVGNLLYNQQLFRNGMRLQAFYELGNGQEAQREFQYIKVTDGQGTYKWTDYNGDGIQQLDEFEIAEYADLAQYIRIYTNTVNYLPSNKNKLQLALFVNPSVILNSQNQFLKRWNFNLSLNSQNSFFKREKVLVLNPFERNEDQILKNQNILASAQFNPTDKSGWNGNYRFITNQNLINANFSNEERNQDSHLLNVGYWFSKDFRLDWENALHHIENASELFSSRDYILNNIETKPKATYKFTDALQAELSSAFRQKKRQDGEEFLKTLDFTGSLQWERKKTSVRGNFSFINNDFNGNNFSIVGNQMLDGLKPGKNQVWSVFLQQAVNSFIQLNVNYEGRSSEERTIHIGSMQVKASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X491</accession>
    <name>C6X491_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782375.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00776"/>
    <dbReference type="EnsemblBacteria" id="ACU07229">
        <property type="protein sequence ID" value="ACU07229"/>
        <property type="gene ID" value="FIC_00776"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00776"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_10"/>
    <dbReference type="OMA" id="VLVFTTY"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="215" mass="24296" checksum="15AF382D70CF7ABF" modified="2009-09-22" version="1">MKELKENVRIIVADDHGIVRMGLLQTVKRLLPDAIITEVEDFKSLYKVISKEELDLAIMDVNMPNGTVQEAIDYIRNHQPKLKILIFSSQDEELYALRYLKMGAGGYLSKQSSSSVIETALTSMLTTGRYASEAVKEAMFFESVSGNTKTSPVEILSDRELQIANKLAEGLPLKEISNQLNLHSSTISTYKNRLFEKLKIKSIPELVEILRLYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X497</accession>
    <name>C6X497_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ApaG protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782381.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00782"/>
    <dbReference type="EnsemblBacteria" id="ACU07235">
        <property type="protein sequence ID" value="ACU07235"/>
        <property type="gene ID" value="FIC_00782"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00782"/>
    <dbReference type="eggNOG" id="COG2967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128074_0_0_10"/>
    <dbReference type="OMA" id="YVSGCNL"/>
    <dbReference type="OrthoDB" id="1835593at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="SSF110069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="128" mass="14573" checksum="D14AC885BB7E88FD" modified="2009-09-22" version="1">MFSITTFDIKVSVHPEYDSKNSFPSENRFVFRYHITIENLGDHPILLLKRKWLIYDVGFGFTEVEGDGVIGLTPEIAPGESFKYFSNVVLRSGVGNMSGTYFCTHQLTKDFLEIEIPKFNLVAEVLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B4</accession>
    <name>C6X4B4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="12" type="ordered locus">FIC_00799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00799"/>
    <dbReference type="EnsemblBacteria" id="ACU07252">
        <property type="protein sequence ID" value="ACU07252"/>
        <property type="gene ID" value="FIC_00799"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00799"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_3_1_10"/>
    <dbReference type="OMA" id="RCHYCGY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="311"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="834" mass="96973" checksum="324F79AAC1E7BCB5" modified="2009-09-22" version="1">MIILLKFAYAHKRFQLLSTLNFAQIILPLNLKGTFTYKVPDEIMPDIEVGMRVLVSFRGNKIYTGIVFEIHKDEPEGFVPKEIISILDDFPILPPEQIRFWNWISEYYLCNPGEIYRFAFPASLKLESETYLKLKPNVTVEFENLDVNEMYLIQALEVRQLINVTEIEAFIPKKEIVKTIKSLIDLQYIEIDEKIAEKYKAKEVAFLRIKDKESVNKRLAEVLLSLKRSPKQQELLLLILEKETEHPEVPIKKSVIFDEGNFAHTQLKTLIEKGLVEEYLLQKDRLATYEGQIEGLEELTESQQRAKTEIDDAFTNDKNVLLHGVTSSGKTHIYLDKIEETVLAGRNVLFLLPEISLTKQIVQRLERKYGRQLGFYHQKLTDFERVEVWRKVRNNEIKVLIGTRNSLFLPFQNLRLIVVDEEHDSAYKPREVSPFFNAKDAAQVLAKMYEGHLILGSATPSVESYYLAQKEKLQYVFLGERFGDVKLPEFELVNFKEEQDSKKIIGNFSVKLIDDIKSELERNKQTMILHNRRGYSNVVECESCGYVNYCANCDVVMTFHKYSNEMKCHYCGQKASKPKVCPKCHSENLNERGVGVEQIHEEVSRLFPDSEVDRMDVDSMRKKFAYEKLYEKIEESETDIVVGTQMISKGLDFDNIELVAIPKADSLLYVQDFRAEERAYQLITQVSGRAGRTSGEGKVIIQTYNPSHSVFQLIRDNDTASIYAHFLEERRKFLYPPFVKLIMIELKHRRDEKASRSAQFLGSVLRKYLPEECILGPEKSPIAKLNLMYQYQIMLKLPRGKRYLEFKALVLKSLEEMDEITAYQSVKKLIFVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D2</accession>
    <name>C6X4D2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00817"/>
    <dbReference type="EnsemblBacteria" id="ACU07270">
        <property type="protein sequence ID" value="ACU07270"/>
        <property type="gene ID" value="FIC_00817"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00817"/>
    <dbReference type="eggNOG" id="ENOG5032URC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116186_1_0_10"/>
    <dbReference type="OMA" id="TEFYLAY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="179" mass="19256" checksum="C0D92DDFEE96AD4B" modified="2009-09-22" version="1">MDYEKVFKFVLTNLKSITMKKLILASAFALLGITSLNAQSSGYPKLGFHLGLPVGDAGDWYSFNVGVDAAYLWTVAPNFDLGLATGYSHYLVKSDYDDVIDGAGLIPIAATAKYTVAPNFFLGADLGYGLFTNEGADGGFYFQPKIGYESGMTEFYLAYKSVSNNGSIGSINVGINFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E7</accession>
    <name>C6X4E7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ClpS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00832"/>
    <dbReference type="EnsemblBacteria" id="ACU07285">
        <property type="protein sequence ID" value="ACU07285"/>
        <property type="gene ID" value="FIC_00832"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00832"/>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134083_2_0_10"/>
    <dbReference type="OMA" id="IVLYNDD"/>
    <dbReference type="OrthoDB" id="1829294at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="103" mass="11932" checksum="FFECDBD3F63A9BB5" modified="2009-09-22" version="1">MLNSMIKNVRDYESPQREYDEEVALLEKEDEVYKLVLWNDDVNTFDFVIEALVEICGHTLEQAEQCTILVHYKGKCTVKTGSLEILKPMHEKLLARSLTSEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F0</accession>
    <name>C6X4F0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00835"/>
    <dbReference type="EnsemblBacteria" id="ACU07288">
        <property type="protein sequence ID" value="ACU07288"/>
        <property type="gene ID" value="FIC_00835"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00835"/>
    <dbReference type="HOGENOM" id="CLU_3365100_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="3773" checksum="9F7CACEA612EA6A4" modified="2009-09-22" version="1">MGTLLLTATGFEVPQETAKSNSNAAIKRFFICKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F1</accession>
    <name>C6X4F1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00836"/>
    <dbReference type="MEROPS" id="C40.004"/>
    <dbReference type="EnsemblBacteria" id="ACU07289">
        <property type="protein sequence ID" value="ACU07289"/>
        <property type="gene ID" value="FIC_00836"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00836"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_8_3_10"/>
    <dbReference type="OMA" id="WNQAYLF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="94" mass="10380" checksum="3E6E37212C493967" modified="2009-09-22" version="1">MAKVFDENDTKLPRRSEDQSNTGKQISIKETKPGDLVFFATAGGSRVSHVGIVHDIGQGGEVKFIHASTSKGVIISSLNEKYWNQAYLFARRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4J8</accession>
    <name>C6X4J8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782482.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00883"/>
    <dbReference type="EnsemblBacteria" id="ACU07336">
        <property type="protein sequence ID" value="ACU07336"/>
        <property type="gene ID" value="FIC_00883"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00883"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_0_10"/>
    <dbReference type="OMA" id="LNSHHDT"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="165"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="350" mass="39129" checksum="BC43AC8B73E1EE35" modified="2009-09-22" version="1">MEILKNDARNFLIELIETPSFSREEENTALIIEKYLNLKNIPFQRKGNNIWAKNLQFDENLPTVLLNTHHDTVKPNSAYTLDPFEAVQKEGKIFGLGSNDAGASLVSLWAVFTHFYAVKLKYNLIYATTAEEEISGENGVKSILEDLGKIDFAIVGEPTKMDLAIAEKGLVVLNCVAKGTASHAAHTNEDNSIYKAVRDIQKVQNFEFDKVSEVLGKVRATVTIINAGSQHNVVPDQCHFTIDVRTNEHYSNSEILEIFTNELESEIQPRSLALNSSKINLDHPFVFAAQKENCSLYGSPTVSDQALMPFDSVKIGPGDSTRSHTADEFIYQHELDEGIEKYIKILSHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K3</accession>
    <name>C6X4K3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine transporter MetT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782487.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00888"/>
    <dbReference type="EnsemblBacteria" id="ACU07341">
        <property type="protein sequence ID" value="ACU07341"/>
        <property type="gene ID" value="FIC_00888"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00888"/>
    <dbReference type="eggNOG" id="COG1757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043525_0_0_10"/>
    <dbReference type="OMA" id="AMCMIYL"/>
    <dbReference type="OrthoDB" id="580055at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="39"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="237"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="433" mass="46003" checksum="FB0A757C8B520FC9" modified="2009-09-22" version="1">MNRINPQLVAIFPLLIFVCVFLGFGIYYNDFYAMPSPIAAVIGITAAFVLLKGKINQKVDTFLKGCGDGKILTMCIIYLLAGAFATVTAATGSVDSIVNLGLNYISPAYFPVGVFVIASFLSFASGTSVGSIVTLGPIVIALAEKSDSPLGLIGACLLSGAMFGDNLSLISDTTIAATQSLGCQMKDKFRFNSKIALPAALVAIVLLVAIGFNQETSAAVHEFKEFNLVLVLPYVLVVALSLAGLNVFVVLFVGLVFAGLLGFGFGSFDFIGFAKKTYEGFTSMTEIFLLSLLTGGLAALVEKAGGISFLIKNISKVISSKKTALFGIAGLVSVTNLCVANNTISIIISGKVAKEINDKYGLRPQQSASVLDIFSCYIQGLIPYGAQILLLISLSSFKIQYTELIQYAFYLHILLIFTLASIFFGKQNLSVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X513</accession>
    <name>C6X513_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
            <ecNumber evidence="12">2.7.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_01051</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="12"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805786.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01051"/>
    <dbReference type="EnsemblBacteria" id="ACU07501">
        <property type="protein sequence ID" value="ACU07501"/>
        <property type="gene ID" value="FIC_01051"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01051"/>
    <dbReference type="eggNOG" id="COG0818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112343_2_2_10"/>
    <dbReference type="OMA" id="SFRYAAQ"/>
    <dbReference type="OrthoDB" id="2028997at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="13193" checksum="CF301F1A1BEA5E01" modified="2009-09-22" version="1">MRKPTFQKSVLNAVSGLFWMLKSERNFQLEILALLINIILIVFLELTSTDAALIYIVCFAVLSLEILNTAVEKICDVIKPEYDERIKIIKDISAGAVILMAFCSVTVGILVYSKYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X525</accession>
    <name>C6X525_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805798.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01063"/>
    <dbReference type="EnsemblBacteria" id="ACU07513">
        <property type="protein sequence ID" value="ACU07513"/>
        <property type="gene ID" value="FIC_01063"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01063"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_4_10"/>
    <dbReference type="OMA" id="YRPGKWG"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="308"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="4">
        <location>
            <begin position="531"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="590" mass="66593" checksum="DFE0260F2897F783" modified="2009-09-22" version="1">MTSSEKISALRQKMQQNNIDAFIVYSADPHMSEYLPEEWQERAWLSGFTGSAGFVVVTKDKAGLWTDGRYFVQAPKELQGSGIDLMKEGDEATPNYIDWIISEISQDGKVAVNALATSNTNWETLEQKLAVKNIEVVDMPLLKEVWLERTLDKKKNPVFVHPLERAGKSVSDKLGDIRSKMKELNASLHIISSLDDVAWTLNLRGSDVQSNPVFLGYIILTNEEAVLFVDQEKLDDDAKNQMQKSSVSVRDYEDFFAYLKNIKDQKILISANSNQSIIEALKENNTFIKAPVPGNLMKAVKNDTELEGFRTVMQRDGVAMVKFLYWLTHQAGKETMNEFSIGEKLRGFRAEGDNFVGESFGSIVGFKENGAIMHYSAPKEGSKEVTSEDTILVDSGGQYLEGTTDITRTFALGNASEEFKRNSTLALKGLIQLSMVKFPKGTRGVQLDAFARLALWKEGKDYNHGTGHGVGSFMNVHEGPQNIRKDMNPQELIPGMVLSNEPGFYLENHYGIRHENLIAVKEAEKTDFGTFYEFETLTICPFDRNVIEVDLLTQPEKEWLNSYHEWCREKLENSLEGEVKAWFLEQVQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X531</accession>
    <name>C6X531_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-binding proteins-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805804.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01069"/>
    <dbReference type="EnsemblBacteria" id="ACU07519">
        <property type="protein sequence ID" value="ACU07519"/>
        <property type="gene ID" value="FIC_01069"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01069"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_2_10"/>
    <dbReference type="OMA" id="WEINMFY"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="189" mass="21745" checksum="164F8464F146ADD9" modified="2009-09-22" version="1">MHETLKSFILARSSPDERALAQILSCFSSVKTKRNQILTGRDEVCRHYYFINSGSMRIFTTDKNGNERSRYFAFEGNFVTALPSFIDQLPADEYLQSIEPSELLCITRSDFYSLVENVPAFAKIYTEILELGFIAAQKRIYGFQSFNALEKVRWIIRHQPQVLLRLSNKMAATYLGISPSTLSRIKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X582</accession>
    <name>C6X582_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805855.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01120"/>
    <dbReference type="EnsemblBacteria" id="ACU07570">
        <property type="protein sequence ID" value="ACU07570"/>
        <property type="gene ID" value="FIC_01120"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01120"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_10"/>
    <dbReference type="OMA" id="LTFWAVN"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="227"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="359"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="576" mass="64354" checksum="2C64B94AF974B7D5" modified="2009-09-22" version="1">MKIKTKLISGVGLLFAFILLLAAMSIYYVNALKRDTNNILVANYNTLEYSRNMLLALEEIPKNKEAIGVFEKNLAQQKANVTESGEEERTSDLASHFSRLKLNPDDSVLASSIRNDIAELMRLNMDAIERKSSIAGATADRAVSWISAAGTLCFLIAFVLLVNLPGNIANPIKELTESIRQIANQNYKERVRFESNSEFGELARSFNTMAEKLEEYAESKLDKIIKGKKRIETLINNLHDPVIGIDENKKVLFANGEALKISGIKKEHFIGRQIQDVAVTNDLVRDLIKELIQPEVGKTKEPLKIFADGKESYFEKELIDIQVVPTGEKVSQLIGHVILLRNITPFKELDVAKTNFIGTVSHEFKTPISSMKMSIQLLENDHVGTLNTEQKELVENIKDDANRLLKITRELLNLTQVESGNIQLSQEPADPKELVRRAVEATKTPAEQKKMTVEATLPENVSQVLADEEKTVWILINLISNAIRYSYEGGTVKVKVSEEGDHVKFTVKDQGSGIPEQYLAKVFDRYFRVPGTQKEGTGLGLAISKEFIEAQGGTLRVESVWGSGSSFHFTLMRTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D2</accession>
    <name>C6X5D2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="4" type="ordered locus">FIC_01170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805905.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01170"/>
    <dbReference type="EnsemblBacteria" id="ACU07620">
        <property type="protein sequence ID" value="ACU07620"/>
        <property type="gene ID" value="FIC_01170"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01170"/>
    <dbReference type="eggNOG" id="COG1273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048975_0_1_10"/>
    <dbReference type="OMA" id="IRYRKVC"/>
    <dbReference type="OrthoDB" id="1724780at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="3">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="259" mass="29593" checksum="3C58791180AD55BD" modified="2009-09-22" version="1">MRAIWSGAIGFGLVNIPIKLYTATGESNLDLDMLDKDDHSNINFKRVNANTGKEVKYADIVKGYKLEDRYVVLTPEDFEQVNPEKTKLLNIKQFVDIHEIDSVYFESSYFLEPQKNGEEAYKLLLNALLKTQMAGIGTFILREKEILCLVRPYDDKILILNRMRYPEEIRSFEDLKLPSAKKPNNDELEMAESLIKQRATKFDPTKFKNTYNDDLMKIIEAKAKGKTKKIETKEEVLSKATDLMAQLKASLEAGKAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D4</accession>
    <name>C6X5D4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805907.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07622">
        <property type="protein sequence ID" value="ACU07622"/>
        <property type="gene ID" value="FIC_01172"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01172"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033697_1_1_10"/>
    <dbReference type="OMA" id="NWEEWAT"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="8">
        <location>
            <begin position="278"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="516" mass="57102" checksum="AAA022B00E80F68C" modified="2009-09-22" version="1">MKNYVKVMMFSTVFATGLNAQTTDQMVKSIMAETHENSQVEQLAYELLDGIGPRLVGSPKMQQAHDWAVARFKNWGIDARNEQWGEWKSWERGTSSIEMVYPYAKSIEGMQLAFSPATSAKGLTAEVIMLPEFKNAAEFQSFLTKVKGKLVMVSQYQASGRPEYNWKEFATPESFEKMKKESEEASEKWQNSIKATGETSRTLNAKLESAGAAGIISSNWSRGFGVNKIFSAGTKKIPVVDISLEDYGQLYRMTANNTTPKLKIVANSKDKGMAPTFNTVAEIKGTEKPDEYIILSAHLDSWDGGTGATDNGTGTITMMEVARILKKLYPNPKRTIVVGLWGSEEQGLNGSRAYVSAHKEQMPKIQALFNQDNGTGRIANISGQGFLNSYDYLGRWMNAVPKELTKDIKTTFPGFPGGGGSDHASFVAAGVPAFMLGSLNWSYGNYTWHTNRDTYDKIVFDDVKSNVAMIAILTYMASEDAEKTSSERIKLPTDPRSGEPMKWPEVKEPTRKGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F2</accession>
    <name>C6X5F2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805925.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01190"/>
    <dbReference type="EnsemblBacteria" id="ACU07640">
        <property type="protein sequence ID" value="ACU07640"/>
        <property type="gene ID" value="FIC_01190"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01190"/>
    <dbReference type="eggNOG" id="ENOG5031GER">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_5_10"/>
    <dbReference type="OMA" id="MAFKFEN"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="13338" checksum="DDB5A6C13C85E422" modified="2009-09-22" version="1">MSFKFENLRVWKIAMDVGEEIHTLSQSFPASEKFNLSSQICRAADSVALNISEGSIGQSNPEFKKFLGYSIRSIAEVVTCLYKAKNRKYINDEIFNNTYNTLFNLMNQLIALRNSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G6</accession>
    <name>C6X5G6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01206"/>
    <dbReference type="EnsemblBacteria" id="ACU07654">
        <property type="protein sequence ID" value="ACU07654"/>
        <property type="gene ID" value="FIC_01206"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01206"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_5_10"/>
    <dbReference type="OMA" id="HIFRHAY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="295" mass="33901" checksum="107B777D4AFAA4D7" modified="2009-09-22" version="1">MAALALHFKTLPTELDPEQVKDYLFELQQRSKTPSQTYFKHTVYGLRFLLKTEGLPYSFLHLPAIPQVKKLPVILSREEIWRMLQSAELLKHKLLIGLIYGCGLRCMEVRNIELQHLDFDRKMLHVVQGKGPKDRYVPLSEHLIRGLRTFINIENPNQYLFNGNQNRNIEEIDASTPLRTGASPFASKDFDSRYSQRGVQWVIKTISKKAGITKEVHTHTLRHSYATHLLEDGVSIIMVQKLLGHERIESTMEYLHSLSVHRRDLSALGSAAAQSFGYGIYFMQQECRPEVMAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5N0</accession>
    <name>C6X5N0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806003.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01270"/>
    <dbReference type="EnsemblBacteria" id="ACU07718">
        <property type="protein sequence ID" value="ACU07718"/>
        <property type="gene ID" value="FIC_01270"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01270"/>
    <dbReference type="eggNOG" id="ENOG5033RFD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766618_0_0_10"/>
    <dbReference type="OrthoDB" id="880351at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972345" evidence="1">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="365" mass="42976" checksum="B574830A014DE801" modified="2009-09-22" version="1">MKVNYPFLLLLLLGFSFSCNSKEDNCFTSSRENFIYIGKPEFTADQIRKEKPDYLQIYELKQFRSFKTDSIDVNSYDVRKEDEARRKHELYLKNYEIFNTLFYEQFQYYAKQKVGDAEYALGRNMLGYWLLKIRNNEPKAYFLGLSFSHYYFNQIQKQAIIRDGELRIEGSFVKIVKVPGLPGYDDYSAIEDGKLFRIKLADLEKDSDDDGYNDIFEDSFGLNPESADTDSDGTDDFNDLNPLYKSKKNKFTLLFEQLLGEYGSLERQDFTKLKYYFDVYETDCEHFQSVNPKLRTIFTSKSERKKSYYLQHTDVVQSGISKLKKDPINADKFYVEKWGSSFSNDLVVEFKNEKWIIKMIGGSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5N7</accession>
    <name>C6X5N7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01277"/>
    <dbReference type="EnsemblBacteria" id="ACU07725">
        <property type="protein sequence ID" value="ACU07725"/>
        <property type="gene ID" value="FIC_01277"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01277"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015760_0_0_10"/>
    <dbReference type="OMA" id="GHTMQYH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="5">
        <location>
            <begin position="14"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="868" mass="98798" checksum="24494CAACCA9CF4B" modified="2009-09-22" version="1">MMEEQENHHEESLKKVSGLYKDWFLDYASYVILDRAIPSIFDGFKPVQRRIMHSMRELEDGRYNKVANLVGNTMKYHPHGDASITDAMVQIGQKELLIDMQGNWGNIYTGDSAAAARYIEARLTPFALEVVFNPKTTHWVKSYDGRNNEPIDLPVKFPLLLASGVEGIGVGLSTKIMPHNFNELINASIAHLKNKSFELYPDFLTGGMLDVSNYNDGERGGRIRTRARIIQKEKNTLCITELPFGKNTGDLIDSIIKANEKGKIKIKKIEDNTSDKVEINIHLNSDVSPDKTIDALYAFTDCEIPISPNACVIVGNRPEFLTVSEILRRNTDHTVSLLKKELEIELHELQEKWHFASLEKIFIENEIYQEIKGKSSKEEVYTAVDKGLKPFTGNLLRAVTTDDIIKLTELPFMRISRYDQDKAIENLLALEAKIEQVKYHLDNLVAYAIDYFTGIQKKFGKGKERKTELRIFDTIDATKVAVANEKFYANFEEGFIGTSLKKDQYLFDCSDIDDIITFQKDGTMKVVKVEPKTFIGKNIEHVAVWKKNDKRTVYNMIYREGKEGPYYMKRFSVTGVTRNTDYKLASDSKGSEMLYFSANPNGEAELVTVLLKSNARIRKNKIEIDFSEIGIKGRDSKGNLVTKYPVKKVDLKEEGHSTLAPRKIWFDDTVRRLNADARGTLLGTFKGDDKILTVNAQGDAKLISFDLMNRFEDEYLVLEKWKPEQPITTIYYDGEKQMYFIKRFLLENTPNVQHFLPTEHPKSFIEQVIVANGSTAEIVFAKDKDKTKDPETINIDEFISVKGIKAIGNQLTRSKVKTINITVPEPEEINPGFDVVETTEGHISFIDEDVKDGDFPDEGTIGSLFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U7</accession>
    <name>C6X5U7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806070.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01337"/>
    <dbReference type="EnsemblBacteria" id="ACU07785">
        <property type="protein sequence ID" value="ACU07785"/>
        <property type="gene ID" value="FIC_01337"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01337"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_6_5_10"/>
    <dbReference type="OMA" id="GQFAWML"/>
    <dbReference type="OrthoDB" id="2025630at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="142" mass="16311" checksum="B26ED4B2D3D9C994" modified="2009-09-22" version="1">MNYFTSTRSNAAIIDIVVLVVRIFVGFAMLSHGFPKLQQLLSGEEIKFYEFLFFSAKTTLILTVFAEFVCSIFIILGLFTRFAVFFLIITMAVAGLLVHSADPFEKREMSLLYLSIYLMLFAFGPGRYSVDSMITRRRESQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z9</accession>
    <name>C6X5Z9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806122.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01389"/>
    <dbReference type="EnsemblBacteria" id="ACU07837">
        <property type="protein sequence ID" value="ACU07837"/>
        <property type="gene ID" value="FIC_01389"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01389"/>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044848_1_0_10"/>
    <dbReference type="OMA" id="LIFGLHV"/>
    <dbReference type="OrthoDB" id="991285at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="368" mass="42566" checksum="957001D7DFCB2C36" modified="2009-09-22" version="1">MHQFTIGVEEEYQIIDVESRDLVSHVSKIIEGGKATLHENLKHEMHESVIEMETGICQNIEGVKVELNDLRRRLIQVAHDNNLRVSGGGTHPFSRWQDNHITKDDRYDKIVNDLGDVARSNLIFGLHVHVGIPDREEGVRIQNAMRYFLPHVYALSTNSPFWMGRNTGFKSYRQEVFAKFPRTGIPSYFSSAAEFDAYINLMIKTGTIDNAKKIWWDLRVHPFYPTIEFRICDMPLRVEETVCLAAIMQCLVAKIYKLHQQNISFRSYRRLMITENKWRASKEGIHAHLIDFGKETSVPYCDLLKELLEFIDDVVDGLGCRNEVEYAYEIMKNGTGADRQLKVFEETGDFKKVVDYMISETEYGITCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X617</accession>
    <name>C6X617_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, aldo/keto reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806140.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01407"/>
    <dbReference type="EnsemblBacteria" id="ACU07855">
        <property type="protein sequence ID" value="ACU07855"/>
        <property type="gene ID" value="FIC_01407"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01407"/>
    <dbReference type="eggNOG" id="COG4989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_8_0_10"/>
    <dbReference type="OMA" id="VVYAWVM"/>
    <dbReference type="OrthoDB" id="1367386at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="5"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="287" mass="32642" checksum="82B889D481BF9700" modified="2009-09-22" version="1">MNFSPIIVGTMRWGIWGADHSEKEVQHLIETALSEGLTTFDHADIYGDYTTEKLFGDAFNQMKTNRESVQFITKCGIEMPCANNSFKLKSYNYSKDYILKSVENSLKNLKTDYIDVLLLHRPSPLMDPHEIADAFEVLKSEQKVKCFGVSNFSPAQFDLINNSFPLVTNQVEISVSQTRAFGDGTLDQMMLRSLRPMAWSVMGNYFSKVSEQNLRIKKVLAELCPKYEAAENQILLSFILRHPAKILSVIGTSKAETIRVLKRSLHINLEREDWFKLLEASTGEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X621</accession>
    <name>C6X621_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07859">
        <property type="protein sequence ID" value="ACU07859"/>
        <property type="gene ID" value="FIC_01411"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01411"/>
    <dbReference type="HOGENOM" id="CLU_3356319_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="36" mass="4113" checksum="96A5BBF0E1C5B2C8" modified="2009-09-22" version="1">MDGSVVSWHYARKSEQGQKGIGEEEFSAIMKKKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X629</accession>
    <name>C6X629_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-Ig-H3/fasciclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01419"/>
    <dbReference type="EnsemblBacteria" id="ACU07867">
        <property type="protein sequence ID" value="ACU07867"/>
        <property type="gene ID" value="FIC_01419"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01419"/>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031281_1_1_10"/>
    <dbReference type="OMA" id="VWVNEAK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="178"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="322" mass="33770" checksum="81C20A6BB6E307F3" modified="2009-09-22" version="1">MKNILIMKNLLKLFAVALMFGFVMISCEESRDEMPNSGSIYDLASRDADLSNLKAAIDKAGLSTTLSATGTFTVFAPSNAAFTQFLSENGFASLNDVPAAALKEILLNHVLSDKVMAANVTTGYVSTMAKSSASSTRNLSMYINTASRVKINGISTVTQTDIAASNGVIHKVDKVIGLPTVVTHAMANPNFSILVSALTRNDMPNFAGILSGSASSPFTVFAPTNAAFTSLLTELTLPNLAAVPTAVLENALKYHVVAGANVASNDIVNNMTVTTFQGGTFKITTNGGVKITDANTRVANVIATDVQCSNGIIHVLDKVILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X657</accession>
    <name>C6X657_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriophage CI repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01447"/>
    <dbReference type="EnsemblBacteria" id="ACU07895">
        <property type="protein sequence ID" value="ACU07895"/>
        <property type="gene ID" value="FIC_01447"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01447"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105312_0_0_10"/>
    <dbReference type="OMA" id="GYEWIME"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="174" mass="20044" checksum="F6FB506922025B50" modified="2009-09-22" version="1">MFYICDMSLNDRIAKIIAYSGLTPSEFADEIEVQRSNISHIASGRNKPSLDFLVKIKTRFPELQWDWLISGEGEMQKPQDEKIEKPKPTAVPDLFSIIADENFGITESEDKVSVETPRESKITAQQSIRENTDDSQRLENSEQTLHTKVADKQQDKIKRIVWFFESGKFESFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X679</accession>
    <name>C6X679_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806202.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01469"/>
    <dbReference type="EnsemblBacteria" id="ACU07917">
        <property type="protein sequence ID" value="ACU07917"/>
        <property type="gene ID" value="FIC_01469"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01469"/>
    <dbReference type="eggNOG" id="ENOG5032SSW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160616_0_0_10"/>
    <dbReference type="OMA" id="CEKEARF"/>
    <dbReference type="OrthoDB" id="1673648at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="123" mass="14008" checksum="215CDF160480BC88" modified="2009-09-22" version="1">MRKLKFFAIGFIPGLLLVFFILNKKGASCSGYLPNSRVIAESLSKEAIYSDAFSAEMKANNISEEFLKDSIMTTGNVDFDKSRAQQKPCPTYVLLYPKKNPRFEISFEKCTDKTTYQTLNKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X687</accession>
    <name>C6X687_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epoxyqueuosine reductase</fullName>
            <ecNumber evidence="7">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Queuosine biosynthesis protein QueG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">queG</name>
        <name evidence="9" type="ordered locus">FIC_01477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the QueG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806210.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01477"/>
    <dbReference type="EnsemblBacteria" id="ACU07925">
        <property type="protein sequence ID" value="ACU07925"/>
        <property type="gene ID" value="FIC_01477"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01477"/>
    <dbReference type="eggNOG" id="COG1600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030790_0_0_10"/>
    <dbReference type="OMA" id="ICDTDLS"/>
    <dbReference type="OrthoDB" id="1478472at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00916">
        <property type="entry name" value="QueG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cob(II)alamin binding" evidence="7">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="309" mass="35738" checksum="C9917058F5194E89" modified="2009-09-22" version="1">MNANAVKYAEIIKAKAQKFGFQSCGISKAEFLEEEAGRFENWLKNSHHGEMAYMENHFDKRLDPRKLVEGSKSVISLSYNYYPEENLSDFADLKISKYAYGQDYHEVIKEILREMVAELKNEIGDFDCRVFTDSAPILERSWARKSGIGWVGKNANLLTKQHGSFYFLAEIIADLELTEDYATTDHCGSCHRCIDACPTGAIIGDRIVDGSKCISYATIELKNEIPESFRNKMQDWMFGCDICQDVCPWNRFAKPHQQEKFHPNQILKTYQKQDWQELTQELFSEIFRKSPVKRAKFSGLKRNIDFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X693</accession>
    <name>C6X693_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolases of the beta-lactamase superfamily I PhnP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806216.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01484"/>
    <dbReference type="EnsemblBacteria" id="ACU07931">
        <property type="protein sequence ID" value="ACU07931"/>
        <property type="gene ID" value="FIC_01484"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01484"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_2_1_10"/>
    <dbReference type="OMA" id="CGPDFRQ"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="29097" checksum="19E1B7B1A61859C3" modified="2009-09-22" version="1">MKLKFLGSGTSQGIPVIGCHCEVCSSTDHRDRRMRSSALVSTNSNKKILIDCGPDFRFQMLDNQEDNIDAVMLTHEHNDHVIGLDDLRPLIFKNRHDMPLYCSARVGNEIKQRFSYAFADVKYPGAPSFQLHEINGSFTLFDVEITPVEVMHHLIPIYGFKVNKLAYITDASAISDAEKEKLRNLDYLILNCIRKEHPHPAHFILPQILELNKELQPKKMYLTHISHHLGRHAQTESELPENVHLAYDGLELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F7</accession>
    <name>C6X6F7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806280.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01548"/>
    <dbReference type="EnsemblBacteria" id="ACU07995">
        <property type="protein sequence ID" value="ACU07995"/>
        <property type="gene ID" value="FIC_01548"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01548"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_1_10"/>
    <dbReference type="OMA" id="FFEHLLF"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970742" evidence="1">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="191"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="437" mass="49674" checksum="2A0305FA48A3E244" modified="2009-09-22" version="1">MKKRLLSAGAAAFLGMLAHAQQIKFEEYDLPNGMHVVLHQDNSAPVVTTGVMYHVGAKDEAVGRTGMAHFFEHLLFEGTKNIKRGDWFKIVSSNGGTNNANTTNDRTYYYETFPSNNEQLGLWMESERLRSGTVNQTGVDTQREVVKEEKRLRMDNQPYGNLFTAVQNNLFTEHPYHWSTIGSMEDLNAATLSEFQDFYKKYYVPNNATLVVAGDINPEQTKKWINEYYADIPKGTVYPKNFAKDEPITKEKEVTVTDKNIQLPAYVFAYRTPSNKEKDAYILDMLSSYLSNGKSSVLYKKLVDQEKKALEVQAFNEGLEDAGIFAFFAIPMGATSKSTLQSDIDTEVRKLQTTLISEEDYKKLQNQYENQFVNANSSIQGIASSLATYHVLHGETNLINKELDIYRSVTRQDIMNAAKKYLNPNQRVVINYLPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H1</accession>
    <name>C6X6H1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="2">FNR</shortName>
            <shortName evidence="2">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806294.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01562"/>
    <dbReference type="EnsemblBacteria" id="ACU08009">
        <property type="protein sequence ID" value="ACU08009"/>
        <property type="gene ID" value="FIC_01562"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01562"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_5_10"/>
    <dbReference type="OMA" id="PEKVIYD"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="350" mass="38246" checksum="EB8C3E85CEB3527A" modified="2009-09-22" version="1">MITSDILIIGAGPTGLFAVFEAGLLKMKCHIIDALPQPGGQLTELYPKKPIFDIPGFPSINAGELVDNLMEQIKQFQPGFTLGETAQTLTKLEDGTFKVITNKGTVHHAKAVAIAGGLGTFEPRKPTIENIADYEEKGLEYFIKEPEHFRGKKVVIAGGGDSALDWSIFLSDIASEVTLIHRRNEFRGALDSVEKVQALKDQGKIRLITPAEVTGIKGEGKVSAITIEKEGETYDYETDYFIPLFGLTPKLGDLANWGLNIEKNAIVVNNALDYQTNIPGVYAIGDINTYSGKLKLILCGFHEATLMCQSVYNMLNPGKRYVLKYTTVSGVDGFDGSRKEAEKAVVKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6J0</accession>
    <name>C6X6J0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806313.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01581"/>
    <dbReference type="EnsemblBacteria" id="ACU08028">
        <property type="protein sequence ID" value="ACU08028"/>
        <property type="gene ID" value="FIC_01581"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01581"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452982_0_0_10"/>
    <dbReference type="OMA" id="FFKYDWK"/>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="20335" checksum="C73B15B3F1B32D8B" modified="2009-09-22" version="1">MLELLQQPLPWYVAGPLIGLTVPALLILGNKSFGISSSLRHICASCLPANIPFFKYDWKKEAWNLFFVFGIFLGGVITMLFFSNPNPVEVHPNLAKELAGYGITDFSNLVPTQLMNWESLFTVRGLIMMVGGGFMVGFGTRYAGGCTSGHSIMGIANLQLPSLIATICFMIGGFLMANVLLPIILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6J2</accession>
    <name>C6X6J2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01583"/>
    <dbReference type="EnsemblBacteria" id="ACU08030">
        <property type="protein sequence ID" value="ACU08030"/>
        <property type="gene ID" value="FIC_01583"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01583"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2897560_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="62" mass="6906" checksum="6A4A4A11B8996162" modified="2009-09-22" version="1">MCKLELVEGRFQITEAEITPELQLENSEQDRDKALKVLEKSKAACLVTNSMKTAVTLNIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB0</accession>
    <name>C6WZB0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00520"/>
    <dbReference type="EnsemblBacteria" id="ACU06978">
        <property type="protein sequence ID" value="ACU06978"/>
        <property type="gene ID" value="FIC_00520"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00520"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_4_10"/>
    <dbReference type="OMA" id="LILEMAV"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="46"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="160" mass="18455" checksum="A744DA6306D1ADAF" modified="2009-09-22" version="1">MATALRFKKMFNLKNFNAMSNLIRRNSFFDDFITKDLFELATPKFAKSEFTLPSVNVKEVNDGFTIEVAAPGMKKENFKLNLERNVLTISSENQAEQEEKDENGAFTRREFNYSSFTRSFTLPEIVDSEKIEASYEDGILKINVPKKEVSMQNIKTIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE5</accession>
    <name>C6WZE5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease R</fullName>
            <shortName evidence="5">RNase R</shortName>
            <ecNumber evidence="5">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnr</name>
        <name evidence="7" type="ordered locus">FIC_00002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781627.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00002"/>
    <dbReference type="EnsemblBacteria" id="ACU06480">
        <property type="protein sequence ID" value="ACU06480"/>
        <property type="gene ID" value="FIC_00002"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00002"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_7_3_10"/>
    <dbReference type="OMA" id="DWYEYRS"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="635"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="718" mass="81954" checksum="58671D77F61E47EB" modified="2009-09-22" version="1">MAKKSKFISHKNNQKLQDLGRLILGFMNKQSTKIYNYKQIADGIDYRNPRQRELVIQALHRLLSDQRVKEVEKGKYIINLKIEGTVSGTIDFNQAGNAYVKVEEFDDDVFIHSKNVKDALQGDQVLIVTYHFKGKKLEGSVLEVIKRNREEFVGTFQLINHKDFGFVVCDKKTINTDIFVPKGKIGGAQDGDKVVVKMTDWKSGEKNPEGEIIKVLGAPGEHETEIHSILAEYGLPYSFPAEVEKEADDIDRTIHDSEVAKRRDMRGICTFTIDPKDAKDFDDALSIQKLNNGNWEIGVHIADVSHYVQPGTLLDDEAYDRATSVYLVDRVVPMLPEVLSNDVCSLRPNEDKYTFSAVFEMDENADVVNEWFGRTVIHSDRRFAYEEAQERIETGTGDLAEEILTLDRLAKILRKERIRNGAITFDRSEVRFNLDENSEPIGVYFKISKDSNHLIEEFMLLANRKVSEFISLNRKGEPTANTFIYRIHDDPDPTKLEALRDFVGTFGYQMDLANTKKVAESLNRLLQDVKGKGEENMIETLAMRSMSKAVYSTNPIGHYGLGFDFYSHFTSPIRRYPDLIAHRLLQHYLDGGKSPNKQDYEEKSKHCSAMERLAADAERDSIKFMQVKFMEKHLGEEFTGVISGVADFGFWVQIPENGAEGLIKLRDLMDDSYSYDPKNHLVHGARTGNQFQLGDKVRIKVMKANLIQKQLDFKIITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG0</accession>
    <name>C6WZG0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="9" type="ordered locus">FIC_00017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781642.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00017"/>
    <dbReference type="EnsemblBacteria" id="ACU06495">
        <property type="protein sequence ID" value="ACU06495"/>
        <property type="gene ID" value="FIC_00017"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00017"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_1_10"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="200"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="318"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="362"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="403" mass="46878" checksum="14FAA4DA6448604B" modified="2009-09-22" version="1">MLDNKEHLYEKAVLVGVITQNQDEEKLVEYMDELEFLALTAGATVVKRFTQKLTQPDPKTFIGSGKAQEVRDYIKENDIGTVIFDDELSPSQLKNLEREIEVKILDRTNLILDIFAQRAQTSYARTQVELAQYQYLLPRLTRMWTHLERQKGGIGMRGPGETEIETDRRIIRDRISLLKEKLKTIDRQMATQRNNRGKVVRAALVGYTNVGKSTLMNAISKSDVFAENKLFATLDTTVRKVVIGNLPFLLTDTVGFIRKLPTQLVESFKSTLDEVREADLLIHVVDISHESFEDHIDSVNQILMEINAHQKPMIMVFNKIDDFSYEKKDEFDLTPESRKNIPLAEWQNTWMSKSKFPTVFISALTKENFEEMKKMIYDEVLKIHISRFPYNDFLFEYFEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ1</accession>
    <name>C6WZJ1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781673.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00050"/>
    <dbReference type="EnsemblBacteria" id="ACU06526">
        <property type="protein sequence ID" value="ACU06526"/>
        <property type="gene ID" value="FIC_00050"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00050"/>
    <dbReference type="eggNOG" id="ENOG502ZAWD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066214_0_1_10"/>
    <dbReference type="OMA" id="EWEINDS"/>
    <dbReference type="OrthoDB" id="1509557at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005901">
        <property type="entry name" value="GLPGLI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09697">
        <property type="entry name" value="Porph_ging"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01200">
        <property type="entry name" value="GLPGLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="267" mass="30498" checksum="791B26D133FEC130" modified="2009-09-22" version="1">MKKAVVITLIFISQIIFSQATRFIYQVTMKPDSTNRTDIKTETAYLDATPLKSVFYSENRLKRDSLMQRVRQTGNFDRTQMANLRSNMDFTVEKDFNSGSKVFSSRIGRDQYSYNEDRATDWQILPETTTIGDYKAQKAQTQFAGRTWFAWFTTDIPLQDGPYKFSGLPGLIIKVEDSKGDYSFDLKESKKIATIPTLEQRGSVIAVNRAAYNKQLEKFKKDPTSFRPSGGRTGGEMRSQASAAQRKENEARLNEEAKKNNNPIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ6</accession>
    <name>C6WZJ6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="7">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00055"/>
    <dbReference type="EnsemblBacteria" id="ACU06531">
        <property type="protein sequence ID" value="ACU06531"/>
        <property type="gene ID" value="FIC_00055"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00055"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_3_1_10"/>
    <dbReference type="OMA" id="PWGGSAY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="6">
        <location>
            <begin position="516"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="643" mass="70949" checksum="68A8F5E6585AAC49" modified="2009-09-22" version="1">MYVQKPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVEDMKILFNEIPLDEISVSMTMNGAVLPVLAFYIVAAEEQGVSQQQLSGTIQNDILKEFMVRNTYIYPPTPSMKIIADIFEYTSKNIPKFNSISISGYHMQEAGATPVLEMAYTLADGLEYVRTGIKAGMAIDDFAPRLSFFWAVGMNHFMEIAKMRAARVIWANLIAPFNPQNPKSLALRTHSQTSGWSLTEQEPFNNITRTAIEALSAALGGTQSLHTNALDEAIALPTDYSAKIARNTQLILQLESGICDVVDPMGGSHLVESLTQQMIDEAMKFIDEVEKEGGMTKAIEAGIPKMRIEEAAAKKQAKIDGGEEFIIGVNAFKSSQKQLELEILDIDNSEVRRKQIELLEHIKSTRNAEKASEILEKLKEAARSGNGNLLEICIEAARRRVTLGEMSDAMEENFGRYKANIRTIQGVYAMNASKNEYFGKALELTQKFEDHEGRRPRIMVVKMGQDGHDRGAKVVATAFADMGFDVDVAPLFQTPEEVAKQAVENDIHILGVSSLAAGHKTLVPQVVEELKKLGADDIKIVVGGVIPQQDYEFLYENGADFIFGPGTNLPKSACEILEEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL4</accession>
    <name>C6WZL4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00073"/>
    <dbReference type="EnsemblBacteria" id="ACU06549">
        <property type="protein sequence ID" value="ACU06549"/>
        <property type="gene ID" value="FIC_00073"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00073"/>
    <dbReference type="HOGENOM" id="CLU_3356314_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="36" mass="4422" checksum="4E65161D82E24DFB" modified="2009-09-22" version="1">MPLIRNLLIYKELHFKPTHFERKISRARKIKAEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM7</accession>
    <name>C6WZM7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III epsilon subunit</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781709.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00086"/>
    <dbReference type="EnsemblBacteria" id="ACU06562">
        <property type="protein sequence ID" value="ACU06562"/>
        <property type="gene ID" value="FIC_00086"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00086"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030720_1_0_10"/>
    <dbReference type="OMA" id="RVNQHFT"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="407" mass="46641" checksum="E7F213D745761D26" modified="2009-09-22" version="1">MYSVIDIESNGAGFRKESIIEIAVYKYDGHEIVDQFISLVNPESEITPFVQKLTKISPKMVKTAPKFPEIARRVIEITRNTILVGHNIDFDYRMLRQEFKRLGYDFTINTLDTIPLAKKLIPEAESYSLGKLVKSLGIPLVDQHRASGDARATLDLFKLLLIKDKNSEIIQQHHEESNGKTYLNKVRNLTQDLPAARGIIYMQNAEGKIIYFDFVDDLSKFAKHVFSSKLKRWAQIQTDVEQIQYELTGSDLLAKLMMSTKGLRKRESLQYGLYYRNSKYFVEKITNIKTELPLLKFRSFTQGLKAVSFLQARPELDDVAALKKLISLSGRNELWLSAGRVLGEKSFLILENGRLTGFGFYELHTQINSPKKLAAMKIDFTRFSDDIKNDLKLSLLRGDFEIQALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN9</accession>
    <name>C6WZN9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">FIC_00099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781721.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00099"/>
    <dbReference type="EnsemblBacteria" id="ACU06574">
        <property type="protein sequence ID" value="ACU06574"/>
        <property type="gene ID" value="FIC_00099"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00099"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_10"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="341" mass="37239" checksum="C1FD3313C99C140E" modified="2009-09-22" version="1">MGLFDMFTQDIAIDLGTANTLIIHNNKIVIDQPSIVAIERSTGKPIAVGEKAKHMQGKTHEDIKTIRPLKDGVIADFHASEHMIKEFIKQIPGIKGKLFQPALKIVICIPSGITEVEKRAVRDSAQKVNAKEVRLIYEPMAAAIGVGIDVQKPEGNMIIDIGGGTTEIAVVALGGIVCDKSVKIAGDVFTNDIAYYLRTHHNLYIGERTAERVKIEVGSAVEELDMEMEDIPVQGRDLITGKPKEIMVNYKEIARALDKSIIRIEDAVMETLSLTPPELAADIYKTGIYLAGGGALLRGLADRLHKKTGLPVFVAEDPLRAVVRGTGIALKNMDKFNFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP0</accession>
    <name>C6WZP0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781722.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00100"/>
    <dbReference type="EnsemblBacteria" id="ACU06575">
        <property type="protein sequence ID" value="ACU06575"/>
        <property type="gene ID" value="FIC_00100"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00100"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_5_0_10"/>
    <dbReference type="OMA" id="TIQSHSY"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="283" mass="31570" checksum="BB0599BC847E0638" modified="2009-09-22" version="1">MGFLLRLFSKNGLFVFFIFLQLVALILIFSRNSMQQSWIAGQTAAFNSWVSGYIDEGASYLKLKQINDQLVVQNKQLMEQVYGKNSSVVPQFRKVHDTIGGGQIYTFVDGEIVFNSINRKDNYFTINRGRRDGVLPQMGVMAPKGIAGIVINATNSYALVQSVLSLNKIKINASLKKSGYFGTLTWRGDDSRTMHLSDIPKYVPLQVGDTVVTDGKSAIFPQGIMIGKVAGYEVDSKTGFWDISVELSEKMGNLSKIYVVKNLKKAEVQKIQDTLQATINREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR9</accession>
    <name>C6WZR9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00129"/>
    <dbReference type="EnsemblBacteria" id="ACU06604">
        <property type="protein sequence ID" value="ACU06604"/>
        <property type="gene ID" value="FIC_00129"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00129"/>
    <dbReference type="HOGENOM" id="CLU_3328167_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="38" mass="4334" checksum="2F3E845202017474" modified="2009-09-22" version="1">MQMLQGNFTSTVPTQNFATIAAVNEKLFYKSVKFFLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW3</accession>
    <name>C6WZW3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00173"/>
    <dbReference type="EnsemblBacteria" id="ACU06648">
        <property type="protein sequence ID" value="ACU06648"/>
        <property type="gene ID" value="FIC_00173"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00173"/>
    <dbReference type="HOGENOM" id="CLU_217916_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="44" mass="5076" checksum="E1D60E2EEB392519" modified="2009-09-22" version="1">MKKNDTLNEKLLKPKKATIDFLLSYSKSMHVLKTKSKNQIVAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZX3</accession>
    <name>C6WZX3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06658">
        <property type="protein sequence ID" value="ACU06658"/>
        <property type="gene ID" value="FIC_00183"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00183"/>
    <dbReference type="HOGENOM" id="CLU_3381965_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="33" mass="3908" checksum="0D666BBC048A64CA" modified="2009-09-22" version="1">MCFKKGPEIFIHLCGDKYKIIFNIKSVKSPFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY1</accession>
    <name>C6WZY1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide export outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00191"/>
    <dbReference type="EnsemblBacteria" id="ACU06666">
        <property type="protein sequence ID" value="ACU06666"/>
        <property type="gene ID" value="FIC_00191"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00191"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038343_1_1_10"/>
    <dbReference type="OMA" id="PYYYIQP"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="284" mass="31189" checksum="4A38EF7B529A73C8" modified="2009-09-22" version="1">MMKHYIFLFFISFLLNSCISTKDVRYMQPNETLVINGEGLVPYNIPVYRVTKNDMLNLNIVTTPKGDAAQFYSALNASVGGGNTANNAVTTAGPAAGTGQGGNSTFYFNGLKVDSKGDINIMGIGYVKAEGRTLEDITQEIQLRVNENFLDGKSEVRLNTDGITYYILGDVETTEMSGEKKAHKNTLTITEALAINGGLNRTVDRTNITIHRKLPEGIKIAKIDLTREDVMNSPYYWVQNGDEIFLNTRSKNLNGLGKDPIQTLTTGVSVLTTALSIYLILTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X000</accession>
    <name>C6X000_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781832.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00211"/>
    <dbReference type="EnsemblBacteria" id="ACU06685">
        <property type="protein sequence ID" value="ACU06685"/>
        <property type="gene ID" value="FIC_00211"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00211"/>
    <dbReference type="eggNOG" id="ENOG502Z7XW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044582_0_0_10"/>
    <dbReference type="OMA" id="HVVWEHD"/>
    <dbReference type="OrthoDB" id="861463at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021272">
        <property type="entry name" value="DUF2851"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11013">
        <property type="entry name" value="DUF2851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="422" mass="49339" checksum="A78339FD816A1082" modified="2009-09-22" version="1">MNEKLLQYLWNFKIFNSFDFKDVNGNSLEILDFGKWNFDSGPDFLYGKIKFKGLVLAGHIELHVKSSDYIFHRHTGNPEFDNLILHAVYFHDTEIDELNGRQIPTLELKDYIDGNILSKYESLLVQRTFIPSENIFDAEKIPLHFAEETLFKKLSEKSVETEAALKICKNDYEAVLFQNLAYAFGLKANAQIFRQLAENIDFSVLNKIRQNVTQLEALFFGMCGWLEKPEDAQMQVWKREFEFLVAKYQLKPTRVIPKFSKLRPPGFPTIRLSQLASLYHLNQNLFSKLMYAKNIREISAVFENVKASEYWDKRFNFRKTSSTEGEKYLTEEFITLVLINAVLPLKYTYHKNADDSINDQIIGFYRNLPPEKNSVIDGWKKLKVPINTALQSQAFIYHYKNYCQPKRCLDCAIGFQLLRNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X022</accession>
    <name>C6X022_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00233"/>
    <dbReference type="EnsemblBacteria" id="ACU06707">
        <property type="protein sequence ID" value="ACU06707"/>
        <property type="gene ID" value="FIC_00233"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00233"/>
    <dbReference type="eggNOG" id="ENOG5033ZZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534027_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="513" mass="61589" checksum="AC5464FF27B507C5" modified="2009-09-22" version="1">MMENFINQIKENKLPEHVYELLTAETGKENITAMWLYRPEHQKAALLTVLCKDRLLLQRTFDYLFIGDTFEQDGLLISMLDDSDMVQQCEDRYLFFSRYARKEDQIYGHEKDYGRFNIVDSDLVSLKARYLKEEQLLMKYTEELIVDEQVGATLFYLKNIQHDVEFLEYIRFGKPFEDFALAERLRQIEALIPEVKQFFVKHNNHYYILRQIENEDIVEYMDEYQDHLRKIKEEMKKIVLQNMKAKQPKNTPLKPTVSHPFMKDPTIRKALHPLLQTAYLEEVYFFHEITAIKEKSQHHHYYLLALVSNENRKEEKRIAEKINKELPRDMEFTIIYHTRLWIQENVYQSQHFLKSLMNGDHKIYTNDFHAKIHWDDDDAYRCDDAFIYHRREKNIYKRHLKGVERNEKAAMVSIIASELNEYFVQILINRLYDSAGYLSEISDVKVLWDLVLYADPRASQLEDQLHKLSFDLIGYLSMHRKDKKPGLHLHQDEKKKIFCLLNHLKNPHTLPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X078</accession>
    <name>C6X078_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00296"/>
    <dbReference type="EnsemblBacteria" id="ACU06763">
        <property type="protein sequence ID" value="ACU06763"/>
        <property type="gene ID" value="FIC_00296"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00296"/>
    <dbReference type="eggNOG" id="ENOG502Z7QJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049143_0_0_10"/>
    <dbReference type="OMA" id="LKQGFYN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031345">
        <property type="entry name" value="DUF5103"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17116">
        <property type="entry name" value="DUF5103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="450" mass="52625" checksum="31C26B20B805C672" modified="2009-09-22" version="1">MFSEKGLKANCFMWSIFFRILLQKYGFCLQRHVVWQQFGLFSVIFEHMKIKILFFFLYSAIAFGQDIRSIQLFNPQTNDETPVIGFSEVLILRFDDLSNSSAVYRYTIRHMDRYWKDDGLFFTEIATGSLNGQIDQMQYSFNTLQPYTHYTLTFPNDKMRPKISGNFELIVYKDSQSNPLFTRRFSMMEDGAIVGVNLNRTTDARRPEVNQRVEVQALGNSSALMQNTNSVSLTVVQNNNWNVAVYDKRPSSTLGNKLLFQQMDLSFPGNNEFYYFDNKNLSYAFDMVAGAETVENVNYTYLHPVWAFPLNYQYQPDVSGAYYFRRNDLGIERDADREADYSWVHFALDSERTEQDIHVLGGFNDFVATPENKMVYDENLKKYIAKIYLKQGFYNYILATKNTDGSLNFGKVNGNFWQTENLYQAYLYYKPFGRNYDGLLGYGEFRTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X094</accession>
    <name>C6X094_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781926.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00312"/>
    <dbReference type="EnsemblBacteria" id="ACU06779">
        <property type="protein sequence ID" value="ACU06779"/>
        <property type="gene ID" value="FIC_00312"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00312"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_3_10"/>
    <dbReference type="OMA" id="EIDCGIN"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="352" mass="40756" checksum="C2AF4A9CED215F57" modified="2009-09-22" version="1">MTEDHDEFLDEDLLLPDTADEESAELFEHLSITVDRGQQPLRIDKFLHIFRQNSTRNKISQSCRAGNVVVNGTAVKQNYRVKPGDRISVLLSRPPRENVIIPQDIPLNIVYEDDDLVVVDKDPGMVVHPGHGNWDGTLINALAFHFEKNGVKSDLDRVGLVHRIDKDTSGLLVIAKNEYALSYLAKQFFDRKTKRLYWAFVWGNLDQENGTITGNIGRHLKNRMQMAVFEDGSLGKHAVTHYKVVERFKYMTWVECKLETGRTHQIRAHFKHIGHTLFNDERYEGNQILKGVNMPKYKQFIKNVFEILPRHALHAHTLGFIHPTKKEEMYFESPMPADMLGAVEKWRRYLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B0</accession>
    <name>C6X0B0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine-protein kinase wzc</fullName>
            <ecNumber evidence="8">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781942.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00328"/>
    <dbReference type="EnsemblBacteria" id="ACU06795">
        <property type="protein sequence ID" value="ACU06795"/>
        <property type="gene ID" value="FIC_00328"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00328"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_6_0_10"/>
    <dbReference type="OMA" id="GYGYNHY"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="7">
        <location>
            <begin position="583"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="777" mass="87449" checksum="14BA3B8E16522FBE" modified="2009-09-22" version="1">MDFKEKTAVTKDNGQIKRQIRRYLRWWPLFVLVVLLSVIIAWIYMRYTTPQYMSKASVYVRLSSGPSGGAQDLQSMMLPSGLTTNEVDNELSVIRSKPLLYNVVKALRLEVKTISEGNIKEEELYESSPVFGEITFLKNARKFRSHTYIISPDGDRAFVLHGDNNEIKGVYGRPVVTDYGSFTLMRNLSRKFKQPLKLTVTNPRIVADQLEASISVVIPQKKSSIMELSRVGVNPLRSEDILNELIRQYNTDAIKDKNAEAMATASFIDDRLELITQELGGIESQKENFKSANKIADLQTQAELNLQNASEHTKKLMEIGTQLEMVDSVLRIANSSANDQLLPTNVGMPSGLDGVIEEYNQLVLTRNRTLRQATPSNPAVQQFNRDIASMRELIRDNLRKSRTSLQISISQVQNEINKSGTSLSKFPQQERVFRSIERQQNLKESLFLFLLQKREETSIALSVSTPKGKIVNPAYTVTEPVSPKKNIVYLAAVLLGLVLPGAFLYTKFALDTYVHSRRQIREALPDVPVVGEIPNAGEEGATVVKTNDFSSFAESFRIMLTNMKFVLKEPQSGQASVVLVSSSVKGEGKTTVSVNTALTLAQNRKVLLIGADIRNPQFKRFMKLSSHGLSDFLAVPDAEIKPIIEPSGLNPNLDVIPSGSIAPNPTELLASKKFEEMLEQLKPHYDYIVIDTAPMLMVSDTFNLLGYMDMLLYVMRAEHTDKDMFEFAAQLMNENAKGKFAIVLNDVRNIHLSYGNKYGYGYYTDGPKKKRWYKFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D9</accession>
    <name>C6X0D9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06824">
        <property type="protein sequence ID" value="ACU06824"/>
        <property type="gene ID" value="FIC_00357"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00357"/>
    <dbReference type="HOGENOM" id="CLU_3310137_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="39" mass="4811" checksum="194139F77465A935" modified="2009-09-22" version="1">MNFLFHVDKFDVVIRALMKRKVKYYPLKILIMHSPEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E4</accession>
    <name>C6X0E4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781976.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00362"/>
    <dbReference type="EnsemblBacteria" id="ACU06829">
        <property type="protein sequence ID" value="ACU06829"/>
        <property type="gene ID" value="FIC_00362"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00362"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723102_0_0_10"/>
    <dbReference type="OMA" id="PVICIAY"/>
    <dbReference type="OrthoDB" id="1809086at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="49"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="382" mass="44061" checksum="E4445328151E7785" modified="2009-09-22" version="1">MAYLNRYKLKVIYQILRYYLKCKGKRILLIPPTSLNGSFGDELMCLGYIQNNNDNQIDIYTDIDRKDLFGKFENVSFVPDSKLIDWSRYQEICLLGADIMTGSYGKWQTLRMIKKLAIANKLGITTKILGFSLKINNDSEIMDSLKSLSAKTDLFIRDIDSFERARNLRFSNISQVADLAFLTNIDDKPDEGYKDYVTRYKNNFKIAICPNALHASDIGKDLYIEQFASFLEKIYQPNLSFIFLFHDLREHCGELSDRDLSFEIYNILQTKISACFFGRASNAIELKKYLFDVDMTIAARMHFGISGLSLGKPMFGISYEDKFAGLHRLFGLDPNKTITADYRCLLDDIEKCKDFIANISTYQTQIHKCLPNVKELSFKNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I4</accession>
    <name>C6X0I4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase</fullName>
            <ecNumber evidence="9">1.8.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782017.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00403"/>
    <dbReference type="EnsemblBacteria" id="ACU06870">
        <property type="protein sequence ID" value="ACU06870"/>
        <property type="gene ID" value="FIC_00403"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00403"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015841_0_0_10"/>
    <dbReference type="OMA" id="WPIIPMT"/>
    <dbReference type="OrthoDB" id="1055204at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036929">
        <property type="entry name" value="DsbDN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973305" evidence="7">
        <location>
            <begin position="21"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="520"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="691" mass="76617" checksum="AF8001F7BA081B2C" modified="2009-09-22" version="1">MKFKSFFLFCILFLFQGFTAQIKNPVKFKYNINALPNNEYEAVLTATIDSNWKIYSKDLPPDSGIPTEMIVRSKEGLQLIGGVMEVGKKKDEFSEAFGVQIVYYENRAQFKQKFKLKNGSVPANVVAEITYMTCDDRICLAPNTLEFEQKITPTATGASVIEPEEEVLKTTAVTDSAVATESDTVLNVAPSITAEKQEGLKVSTIDFANPLTDCGLETQSNSENFWTYLLLGFFGGLIALLTPCVFPMIPLTVSFFTKGSFNKSKGKRDAIMYGFFILLIFVLLSIPFHIIDGIAGNIFNQISTSVWLNVTFFLIFLFFAGSFFGYYDITLPSSIANKSSKAEDAGGVIGIFFMALTLVIVSFSCTGPILGSLLGSAVTGSANVPMLLTFALAGFGLSWAIVFGLLALFPQALQSLPKSGGWMNTVKVVLGFIELGLALKFLSKADLVSKTFFLKRELFIALWILIALGLVLYLFGKIRFPHDDKKPTISLTRKIIGFLGIGFIIYLLQGLIPGERPKLQHLSGILPPINVSYLHKAEDGILGMHPSHDYFEALEIAKKENKPLLVDFTGYGCENCRKMEEFVWSEPDILPILQNDIVLASLYVDDREALPESEQTSVDMGNGQKKKIKTIGDKWSLFQQINFNNNSQPHYVLLSPDGKVINTPVSGYMSKEDFKSFLTCGIEYFKQTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L6</accession>
    <name>C6X0L6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerC family integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782049.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00440"/>
    <dbReference type="EnsemblBacteria" id="ACU06902">
        <property type="protein sequence ID" value="ACU06902"/>
        <property type="gene ID" value="FIC_00440"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00440"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064910_0_0_10"/>
    <dbReference type="OMA" id="IMFLDIV"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="276" mass="30687" checksum="3261E882111BF5AB" modified="2009-09-22" version="1">MDLFGALDFPNFYDPQIWVSLLTLTFLEIVLGVDNIIFISIISDKLPKEKQRFARNLGLAFAMIFRVVLLLMINWIIGLKEAVITLGWFNEPGTDLPLALSWKDIILLAGGIFLIAKSTFEIHGKMSGHDDAPKPKSSASSLMTMVIIQIIVIDMVFSLDSILTAIGLVDNVLLMIIAVVISIGIMMAFAGPISAIINRYPSLQMLALSFLVVIGVMLVAEGIHQHVSKNIIYSCLAFSLIVEVLNIRFRNKQKSNYLKLNPDLNEDLSITHKDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0R8</accession>
    <name>C6X0R8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01584"/>
    <dbReference type="EnsemblBacteria" id="ACU08031">
        <property type="protein sequence ID" value="ACU08031"/>
        <property type="gene ID" value="FIC_01584"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01584"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2787770_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="68" mass="7761" checksum="C138C04699DF5D05" modified="2009-09-22" version="1">MSHQHYYEVKAEWKNGRKGTLSSTVLNETIECATPPEFPKGEPGIWSPEHFVRRCHQQLFPVDFSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0R9</accession>
    <name>C6X0R9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806317.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01585"/>
    <dbReference type="EnsemblBacteria" id="ACU08032">
        <property type="protein sequence ID" value="ACU08032"/>
        <property type="gene ID" value="FIC_01585"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01585"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_0_10"/>
    <dbReference type="OMA" id="LCITRAI"/>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="28285" checksum="F1795E656871A159" modified="2009-09-22" version="1">MDTIGYIASLFIGISLGLIGGGGSILTVPVLVYLFRVDASVATVYSLFIVGVTSVAGSFSYFRKGLVHLKTALIFGIPSIISVFITRTYIVPAIPEEIMSVGGFIITKDIMLMLVFAVLMIFASYSMIKKCTGADCFPSEDQKVKNTAVILHGALVGFVTGLIGAGGGFLIIPALVGLLKLDIKKAIGTSLFIISLNSIFGFSVSVSQFVIEWNLILKILGLAAAGVFIGSWLSTKIEGKKLKPAFGWFVLVMGVYIIIKEIVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0U6</accession>
    <name>C6X0U6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recF</name>
        <name evidence="9" type="ordered locus">FIC_01613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806344.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01613"/>
    <dbReference type="EnsemblBacteria" id="ACU08059">
        <property type="protein sequence ID" value="ACU08059"/>
        <property type="gene ID" value="FIC_01613"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01613"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_10"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="359" mass="41354" checksum="0DA340BA6162DDCC" modified="2009-09-22" version="1">MVIQKLQLIQFKNHSQQTLEFSPQINCFVGNNGVGKTNVLDALHYLSVGKSFLGNTDLNNIQTDGDFFAIEGKIYDGEKENIIKIQMPRDAKKLIKKNDKSYDRMADHIGFLPSVIISPYDSNLISDSGESRRKFLDAMISQTDSDYLYNLIQYQKTIQQRNALLKSFAKNRYFDPENLEIYNEPLIRFGTAIFIKRTEFLDSILPLIQSYYSIISNGNEQVTVDYHSDLKTSSFEELLNENLDKDRVLTYTSKGIHKDDLVFEMNGNSLKRTGSQGQQKSFLIALKLSQMNRIKELTGKTPVLLLDDIFDKLDDSRVLQLIELVNREHFGQIFITDTNKERTESVVRKINEESKIFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X2</accession>
    <name>C6X0X2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806370.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01640"/>
    <dbReference type="EnsemblBacteria" id="ACU08085">
        <property type="protein sequence ID" value="ACU08085"/>
        <property type="gene ID" value="FIC_01640"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01640"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_1_0_10"/>
    <dbReference type="OMA" id="ACGKGRH"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="245" mass="28745" checksum="3A206F8797D0B8ED" modified="2009-09-22" version="1">MAWFETWFNTPYYHILYNNRDFTEAEEFISRLISDLKVRPNSKIIDLACGKGRHSVFLNKAGFEVLGLDLSDESIRQNNSFENETLKFQVHDMRNEIYPNVNPEKVDAVFNLFTSFGYFDSEEDDKKIFKSVENALLPGGLFVLDFLNEKWVQNTLVPEEEVLRQDITFKISKKIEDHFVVKDIRFSDKGKDHHYFERVKLHSLETIKAYAAEFGFESVKTYGDYKLGAYEAETSPRCINVFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Z2</accession>
    <name>C6X0Z2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ordered locus">FIC_01661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806390.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01661"/>
    <dbReference type="EnsemblBacteria" id="ACU08105">
        <property type="protein sequence ID" value="ACU08105"/>
        <property type="gene ID" value="FIC_01661"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01661"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_10"/>
    <dbReference type="OMA" id="AGWVRKS"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="50"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="20335" checksum="C7BA8835F7C19ED2" modified="2009-09-22" version="1">MSDTKPVIRMDAEPPEGFEGEGFFATKLSSVIGMARKYSLWPLPFATSCCGIEFMAVLNPTYDASRFGMERNSFSPRQADMLMVCGTISKKLGPVLKQVYTQMAEPRWVVAVGACASSGGIFDTYSVLQGIDKIIPVDVYVPGCPPRPEQIIEGVMQVQALCEGESIRRRDMPEYQNLLASYGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X120</accession>
    <name>C6X120_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, (N5,N10-methylenetetrahydromethanopterin reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01690"/>
    <dbReference type="EnsemblBacteria" id="ACU08133">
        <property type="protein sequence ID" value="ACU08133"/>
        <property type="gene ID" value="FIC_01690"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01690"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_8_0_10"/>
    <dbReference type="OMA" id="MNRIGRE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022290">
        <property type="entry name" value="CHP03858_lucif-like_mOase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03858">
        <property type="entry name" value="LLM_2I7G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="348" mass="38294" checksum="A56001B281FC9A69" modified="2009-09-22" version="1">MRKIEFGLMTFADMAPETVSGKGLNAHQRLQDLLEEVALADKLGIDVFGIGEHHRPDYAVSSPATVLAAAAAVTKNIRLSSAVTVLSSDDPVRVYQQFATVDAISGGRAEIMAGRGSFIESFPLFGFNLDDYNELFEEKLDLLLKINQSENVTWSGNLRAPIRNLGVYPRALNGEIPVWLAAGGTPASAERAAKLNLPLMLAIIGGMPRQFTPFINLYKKSALANGVKPEDLQVGINNHMFVGENAEEAANDFFPHYAQMMDRVGRSRGWQPMSREQFDYMRAPVGSLMVGSVEQVVEKIVYEHQLFGFTRFFAQASLGFVPHELTMKSISLFATQVVPEVKRRLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X165</accession>
    <name>C6X165_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01735"/>
    <dbReference type="EnsemblBacteria" id="ACU08178">
        <property type="protein sequence ID" value="ACU08178"/>
        <property type="gene ID" value="FIC_01735"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01735"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015150_2_0_10"/>
    <dbReference type="OMA" id="NDIHPLN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972200" evidence="2">
        <location>
            <begin position="25"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="3">
        <location>
            <begin position="104"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="3">
        <location>
            <begin position="397"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="637" mass="71435" checksum="497A856AA6C3ED7E" modified="2009-09-22" version="1">MKTRNISKLICLSAFILLSVALEAKVKLPALVSDGMVLQRDQPVKIWGTADAGEKVQVKFQNKKYFVKADAKGNWSVSLPAQKAGGPYLMTVNEITLNDILFGDVWLVSGQSNMELPMYRVKPLYEDELSSANNPNIRFFAVPQKYNFKNAQQNLDGGKWEAMNAKTISNFSAVAYFFAKNIHEKYKIPVGIVNASLGGSPIQAWMDPVTLKKYPEYLAEAERWKNDDLIKQTETSERALSDAWYAELNQNDPGLKHDWKNLTEYSDWKTMQIPGSWEDFEGSFDGTVWFKKEITISAENAGKPAFLNLGRIKDADETYINGVKVGNVTYEYPPRWYEVAAGVLKEGINVITVRIINGSGKGEFITDKPYELEIGGQKTDLKGEWKYKVGTKMNRSAPGQTFIRWKPTGLYNAMIHPLINYNIKGALWYQGESNIGKPMEYGDLLTTMITDWRLKFRQPELPVVVVQLANFMEPKAQPQESNWAKLRFEQFKVTQTLPKTGLAVAIDLGEWNDIHPLNKKDVGDRLALQAHKIAYNDNVIADGPVYQSVKFEGNIAVISFKPGTDNFAPVDELKGFAVKGSDGKWVWADAKIDGNKIVVSNSKIAKPVAVRYAWADNPLDANLRNTAGLPASPFTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X168</accession>
    <name>C6X168_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-xylosidase</fullName>
            <ecNumber evidence="8">3.2.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01738"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08181">
        <property type="protein sequence ID" value="ACU08181"/>
        <property type="gene ID" value="FIC_01738"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01738"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_0_10"/>
    <dbReference type="OMA" id="LVNYYNT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="7">
        <location>
            <begin position="423"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="600" mass="67065" checksum="E13FCFFDFB8CEA46" modified="2009-09-22" version="1">MVRLLIKIFRRLKYHYPDYIIPLLKSRSNKKIFENMASFHKNRTALVAAIALLSANSISAQIFSNFEYRGNDKIYTQNPLKDNEFYSPILQGCYPDPSITRKGDDYYLVNSSFSMFPGVPIFHSKDLVNWKQLGHVLDRPSQLKVEKAGFSEGIYAPAIKYNKYNDTFYMITTQIASDIGNMVVKTKDPANGWGEVQKLNFDGIDPSLFFDEDGKAYVVHNDAPPAGTERYSGHRVIKVWDYDLEKDQVIAGTDKIIVNGGVDLSQNPIWIEAPHIYKKDGKYFLICAEGGTGGNHSEVVFISDSPRGPYLPAPSNPILTQRYFPKERKEKVDWAGHADLVEGPDGKYYGVFLGIRPNDKHRVNTGRETFILPVDWSGTFPVFENGLVPMKPKMAMPTGIKNQTGTNGFLPNGNFTFKDPLTAKNLDFKWIAMRGPRENFISSAKNGVKIIPFPVNIKAKSPVSALFHRQQHAAFEAEVSVDFKPKSENELSGITCYQSENFNYVFGITKKDKDFYIVLERTEKGASTILASEKITLSKPVKLQVTADGDDYRFSYATDGKNFVNLGGTVSGDILSTDVAGGFTGALIGLYSTVANDIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X185</accession>
    <name>C6X185_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ordered locus">FIC_01755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806483.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01755"/>
    <dbReference type="EnsemblBacteria" id="ACU08198">
        <property type="protein sequence ID" value="ACU08198"/>
        <property type="gene ID" value="FIC_01755"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01755"/>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_2_10"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="1165275at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="103"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="368" mass="40861" checksum="D29EAFDA9B00F60F" modified="2009-09-22" version="1">MKIGILGGGQLGRMLIQEALKYDDEWYTLDPAADAPCANISVLTQGDFGDYETVLNFGHDKDVVSIEIEHVNVNALFELRNLGVKVIPSPEIIKTIQQKILQKEFYLENNIPSPDFQVINNKSEADFPLPFVQKMNTGGYDGKGVQVIRTEHDLQNMWDVPSVLESLVDIDKELSIIVAVNENGETQTFPVTEMVADPVLNLLDFNICPADISDDVRLQIEKISEQFIEAAASSGLFAIELFLDTEGKVWVNETAPRLHNSGHQTQEGNANSQFEQLYRVITNLPIADTGNFGFSGMLNLVGDADYSGKVIYEGLDEVLKLPKTYVHLYGKTETKPGRKMGHINVLADSREELLAKLSHIKSLVKVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B9</accession>
    <name>C6X1B9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GldB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806517.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01789"/>
    <dbReference type="EnsemblBacteria" id="ACU08232">
        <property type="protein sequence ID" value="ACU08232"/>
        <property type="gene ID" value="FIC_01789"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01789"/>
    <dbReference type="eggNOG" id="COG5504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070771_0_0_10"/>
    <dbReference type="OMA" id="GWQIVRA"/>
    <dbReference type="OrthoDB" id="932535at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="326" mass="38186" checksum="B7C9C568E00B6672" modified="2009-09-22" version="1">MKFFRYLLFAGIFAFSITSCKKDAQNRWQVNIEEPAQNVEVTDISKEFYDQALPLAQFQQKYPWFQGTVPDEDFAIRRADPAEAKIYQDAISKIDISKLNTELTSLFSHIKYYFPEFKQPKVYLYSSALQGIMEPVFFQPEQNLVFIDVSAFMGENNPNYQGLEQYWQTSMNPQNIVPKVSASLAEYFVQRDGDSQKFLGELIYNGKIQMLQDAFLPGFPDYLKINYTQEQYSWALANEANVWNYFVESNLVYSDDLRLRERFINPGPFSKFYTEIDNESSPQIGIFTGWQICRTFFEVNPDTKLPDFLKMDSQKIFDESNYKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F3</accession>
    <name>C6X1F3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806551.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01823"/>
    <dbReference type="EnsemblBacteria" id="ACU08266">
        <property type="protein sequence ID" value="ACU08266"/>
        <property type="gene ID" value="FIC_01823"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01823"/>
    <dbReference type="eggNOG" id="ENOG5033KY6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400306_0_0_10"/>
    <dbReference type="OMA" id="QTVTSAK"/>
    <dbReference type="OrthoDB" id="1559872at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="191" mass="21714" checksum="3A3A963DD52E0EC8" modified="2009-09-22" version="1">MKNILLASLLSTVALSCSKIEETVTQTVTSAKEKAQQKTNEIVQETVNEQLTKLVNAETVTFNEVFPNSNNLALENETGKKVAFPNGTPFYVFKYKTTQRDLLLKTLVEQPTTDETQSKKEFEKVDGSSIVEKITFFEKFLPANTIDLSFLRDIKSDKSIEYYKIKRFPNASTVIYNPKSGMVYQFVEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H2</accession>
    <name>C6X1H2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08285">
        <property type="protein sequence ID" value="ACU08285"/>
        <property type="gene ID" value="FIC_01842"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01842"/>
    <dbReference type="HOGENOM" id="CLU_3328172_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="38" mass="4495" checksum="D18EAF7642BADAA9" modified="2009-09-22" version="1">MQTGKTSANNYYFFPAFHKTNLRIYLGQNPDQYIIKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M3</accession>
    <name>C6X1M3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806621.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01894"/>
    <dbReference type="EnsemblBacteria" id="ACU08336">
        <property type="protein sequence ID" value="ACU08336"/>
        <property type="gene ID" value="FIC_01894"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01894"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033329_1_0_10"/>
    <dbReference type="OMA" id="KSLMIEF"/>
    <dbReference type="OrthoDB" id="218801at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07986">
        <property type="entry name" value="LPLAT_ACT14924-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045746">
        <property type="entry name" value="ACT14924-like_Acyltransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19576">
        <property type="entry name" value="Acyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="81"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="612" mass="71062" checksum="4254820DBB630941" modified="2009-09-22" version="1">MSLISKHDLISASGLHKLGLLKSPVASAIMRLTKISAVNRLYDVLKDKKGKDFFDSFVRERGLKYIVFEEDLAKVPKTGPFILVSNHPLGAIDGILMTKILTEIRPDFKIMGNFLLEKIEPMKPYVIPVNPFENRKELRKSSTGMRETLKHLQNGGCVGIFPAGEVSNKNNTFNEIHDRAWEKPALKLIKMAKVPVLPMYFHAKNSRLFYQLAKLHPELQTLILPAEMMHKREKPIRIRIGKQVAVRVLEDHDSIEEMGEFLQNKIYMLKSYYERRKSIAEQLKLPNLKLNFPLMKEENVVQNIIDETPPEDIETEISGLRKKDKMLFRNGNYEVYFCTYSEIPSIMREIGRQRELTFRKIGEGSNLPFDLDRYDEHYHHLFLWDAGPKKLVGAYRMALGSEVMKNHGIEGFYTSSLFEFDQELRPFFRKVIEMGRAYISSDYQQKPLPLFLLWRGIVHVCLRNPEHKFLMGGVSISDKFSEFSKSLMIEFMRSHYYDSAVAQYIHPKKEFKVKLKDRDKHLFFDEVESDLNKLDKIIDDLEPEMRLPVLIKKYIKQNAKVVSFNVDPGFNDAIDGLMYIRISDLPESTIKPVLEEMSEQIGNEENNGAENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1N6</accession>
    <name>C6X1N6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806634.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01907"/>
    <dbReference type="EnsemblBacteria" id="ACU08349">
        <property type="protein sequence ID" value="ACU08349"/>
        <property type="gene ID" value="FIC_01907"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01907"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082049_4_2_10"/>
    <dbReference type="OMA" id="AVYANNY"/>
    <dbReference type="OrthoDB" id="1739979at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970544" description="OMP_b-brl_2 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="220" mass="23857" checksum="C5995112A032F2AC" modified="2009-09-22" version="1">MKKLLTSSALCAAALLAAQIDLSSTRFGITGGATMSRVTNAHNPSGPIYSGFGGFLALIPVDSNDQFYLQLGVEYLGAGESGKDKEAKEFEGYDAVYANNYISIPVYFKGYFSESESEFFAMAGPKFNFLMSQNIKNAPLRYTEEGDPETGVQGKASSFNFAVGLGLGFSYKRQLEITGRYDLGLSNTYKGLMSEDGSDPNIAKKKSEQVFSLGLSYIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T9</accession>
    <name>C6X1T9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplM</name>
        <name evidence="5" type="ordered locus">FIC_01960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806687.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01960"/>
    <dbReference type="EnsemblBacteria" id="ACU08402">
        <property type="protein sequence ID" value="ACU08402"/>
        <property type="gene ID" value="FIC_01960"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01960"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_10"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="151" mass="16739" checksum="AFE8F7D9B6B091E1" modified="2009-09-22" version="1">MNTLSYKTVSANKATANKEWVVVDAEGQPLGRLASKVAKILRGKHKTDFTPHADCGDNVIVLNAGKVTLSGNKWADKTYIWHTGYPGGQKSMTALELQKKDSLKVLEKSVKGMLPKNKLGSILFSNLYLYEGTEHKHEAQQPKVININEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U6</accession>
    <name>C6X1U6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01967"/>
    <dbReference type="EnsemblBacteria" id="ACU08409">
        <property type="protein sequence ID" value="ACU08409"/>
        <property type="gene ID" value="FIC_01967"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01967"/>
    <dbReference type="eggNOG" id="ENOG502ZC3R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091991_0_0_10"/>
    <dbReference type="OMA" id="FMYFCEV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="21000" checksum="83B69C9CC2F719E1" modified="2009-09-22" version="1">MKVSEADLANTQNFVELKIAYYDIQEVVISKFKPTGNLRKDVSSLKTGEKTLALQQMIGLPTPKGDGTPPELPVAGFSGGGLTFSLESIYDILSGERKKKERANQYERMNTAVGNIRKYYGEEYFAALKIPAQLTDNFLQFVYTSENLYPYIQANNYEAIAVYIEKYLPIYQRRLRNSSLMEVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V6</accession>
    <name>C6X1V6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01977"/>
    <dbReference type="EnsemblBacteria" id="ACU08419">
        <property type="protein sequence ID" value="ACU08419"/>
        <property type="gene ID" value="FIC_01977"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01977"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010363_5_0_10"/>
    <dbReference type="OMA" id="SGLHISM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4131" evidence="8">
        <location>
            <begin position="27"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="216"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="592" mass="68834" checksum="0E5F6A8823833AC4" modified="2009-09-22" version="1">MQKQPVLILCVSFIIGIVLQDYLLLKTSSVRLLLVVGFLMLALYFVNNFHLRRFRHIPLLFLFVSLGIFAHSLNNRIPQLPDIAGSQNVVFKINRKLNSNEKNRRYEISAWKGDQFFLSVLSVPREEPELDFLHYYKASLYINRLQKAYSDFQFDYGKYLARKNIYFQSYLGGSFATGTRKDVSFSEKIRQKRLEILKKIDESGLSRRTREFTKGIILADRTEMDSGTVQDFSKSGLMHILAISGSHMAIIFWLILLFLNRIFPPKLRNFKIVISLALIWAFAVFIGYGSSVVRSCIMISAYYIYILLQRKPDLLHAMAVAAFIILIADTHQFYDVGFQLSFLAVFGIFWLNQPILNYLPRPKNNFQNFLVNVVSVSVAAQIVTLPLVLFYFHQYSFISILANLIVIPFSEVLIIFSLLMTVLTAFSLEFKLLNLIYDSFVSAALEMIHLFAVAGFAFYRMIPMSMPEVLVSFVMIYFLRFAILRFTIKNAMRIVYFLLLFVALRMLLNYKANEIDEVLVHRYFRENVLSVKKKDRVQFFLINGSDSEKITQYIIEPYLTARRTKNYEIKTLPRGVEEVRINGVTYKLIQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W7</accession>
    <name>C6X1W7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806715.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01988"/>
    <dbReference type="EnsemblBacteria" id="ACU08430">
        <property type="protein sequence ID" value="ACU08430"/>
        <property type="gene ID" value="FIC_01988"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01988"/>
    <dbReference type="eggNOG" id="ENOG502Z9QW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199042_0_0_10"/>
    <dbReference type="OMA" id="YINSPFP"/>
    <dbReference type="OrthoDB" id="960492at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd19375">
        <property type="entry name" value="UDG-F3-like_SMUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032579">
        <property type="entry name" value="DUF4918"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16265">
        <property type="entry name" value="DUF4918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="230" mass="26679" checksum="5A7A0F1849F010B4" modified="2009-09-22" version="1">MQKSFGENVIEFNKKLKYTGTLPPGFDVLNPFFDNPETLEVMTSFYHKFYSDHCSRKFIIGINPSRHGAGVTGVPFTDTKRLESVCGIEMKSARTHEISSVYLYDVIEQYGGAERFYADFYINSPFPLAIIRKKKNGSWLNANYYDDKSLFEAVKKFMVESIRNHISLGLDTSEVFVLGKKNAAFIEKLNSENHFFSKLTVLEHPRYIQQYKSREKQLYIDKYLIALNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X206</accession>
    <name>C6X206_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ordered locus">FIC_02027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806753.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02027"/>
    <dbReference type="EnsemblBacteria" id="ACU08469">
        <property type="protein sequence ID" value="ACU08469"/>
        <property type="gene ID" value="FIC_02027"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02027"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_10"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="101" mass="11367" checksum="C08A1CA4AE9EAA5D" modified="2009-09-22" version="1">MSQRIRIKLKSYDYSLVDKSAEKIVRTVKATGAVVNGPIPLPTNKRIFTVLRSPHVNKKAREQFQLSAHKRLMDIYSSSSKTVDALMKLELPSGVDVEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X209</accession>
    <name>C6X209_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsL</name>
        <name evidence="8" type="ordered locus">FIC_02030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806756.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02030"/>
    <dbReference type="EnsemblBacteria" id="ACU08472">
        <property type="protein sequence ID" value="ACU08472"/>
        <property type="gene ID" value="FIC_02030"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02030"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_10"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="137" mass="14844" checksum="038905FBDDF36830" modified="2009-09-22" version="1">MPTIQQLVRKGRVALTKKSKSAALDSCPQRRGVCTRVYTTTPKKPNSALRKVARVRLSNGKEVNAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGALDTAGVAGRTQRRSKYGAKRPKPGQAAAAPAKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X250</accession>
    <name>C6X250_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02076"/>
    <dbReference type="EnsemblBacteria" id="ACU08513">
        <property type="protein sequence ID" value="ACU08513"/>
        <property type="gene ID" value="FIC_02076"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02076"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_3_1_10"/>
    <dbReference type="OMA" id="ICGHSHI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="19043" checksum="80003537018EF97D" modified="2009-09-22" version="1">MWLMKKILLLSDTHSHLDERILEYAGQADEIWHGGDFGNMEVVETLEKIKPVRGVYGNIDGDGIRRVFPEVLQFRCEEVDVLMIHIGGYPGRYSPLAKKEIGESRPKLFISGHSHILKAMYDQKNNLLHLNPGACGKSGWHKVRTMMRFEISGDKIENLEVIELGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X290</accession>
    <name>C6X290_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="12" type="ordered locus">FIC_02116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02116"/>
    <dbReference type="EnsemblBacteria" id="ACU08553">
        <property type="protein sequence ID" value="ACU08553"/>
        <property type="gene ID" value="FIC_02116"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02116"/>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009678_5_0_10"/>
    <dbReference type="OMA" id="NIKWARK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="126"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="336"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="512"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="695" mass="80591" checksum="6FAFD59E68D2323F" modified="2009-09-22" version="1">MSLNTVKMSIQFNPRDITWLAFNARVLQEATDPNVPLHLRIRFLGIFSNNLDEFFRVRVAGLKRAMDFKNKFITESFYQPPTKILQSINDTVIQQQQNFDKTWKKIQVEMAAQNVYIKTYKNLTEEQKIFTRKYFDETVESNVIPILLHENSAMPYLRDKSLYMGIAMRTKEFQYASNYAIIEIPSRALGRFVLLPSENDEKNVILLEDVIAFNLPHIFSYFGYNEFAAHCFKVTKDAEFDLDNDIRTTLAEKIEKGIKSRRKGKPTRFVFDKEMDKALLEFLIRKLHLTKKDSIIPGGKIHNFRHFMDFPDVFKAYEKPEERTSFDHPQFINKRVTDVIQSTDVLLTFPYHTYTPVIDLLRESAMDPEVKSIQITAYRLASHSKIVNALINAVRNGKDVTVMLELRARFDEESNLGWKEVLEQEGVKVLLGIPNKKVHAKLCVIKKRVHNKTVQYGFVSTGNFNEKTAKIYGDHLLMTADRGIMADINKVFNVLKKPKDDFRPVLKSCKSLLLSPEFMRQSIIQHIDREIAEAKGGRKAEMIIKTNSLSDRELITKFYEAAQAGVTVKLIVRGIYCAVNQKSFKKKIQAISIVDEYLEHARVMYFYAKGNEDIYISSADWMTRNLDHRIEAAAKINQKNLKKEIKDILEIQLSDNVKARVLDKKMSNEYVETGKTKIRSQTETYLYLKNIASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A9</accession>
    <name>C6X2A9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806856.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02136"/>
    <dbReference type="EnsemblBacteria" id="ACU08572">
        <property type="protein sequence ID" value="ACU08572"/>
        <property type="gene ID" value="FIC_02136"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02136"/>
    <dbReference type="eggNOG" id="COG3759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129819_0_1_10"/>
    <dbReference type="OMA" id="LEMFLWE"/>
    <dbReference type="OrthoDB" id="1974703at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38446">
        <property type="entry name" value="PTHR38446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="13430" checksum="2B8F4E46941B3C20" modified="2009-09-22" version="1">MEILSKILIALVALEHLYILYMEMFAWETLGKKTFKDSLKDELFKPTKGLAANQGLYNGFLAAGLLWSLLISDEMWSRNIASFFLGCVIVAGVYGALSASRKIFFVQALPAILALAVLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E8</accession>
    <name>C6X2E8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806895.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02175"/>
    <dbReference type="EnsemblBacteria" id="ACU08611">
        <property type="protein sequence ID" value="ACU08611"/>
        <property type="gene ID" value="FIC_02175"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02175"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_10"/>
    <dbReference type="OMA" id="WRMGWII"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="402" mass="45112" checksum="043B65C090781007" modified="2009-09-22" version="1">MPKISNRAQHMPASPVRKLVPYALRAKQKGIKVYHLNIGQPDIETPETAINAIKNIDLKVLEYALSEGNIEYRTALKDYYHSLGFKDLTTDNFIVTNGGSEALNFAISTLCDDGDEVIIPEPYYANYNGFTNTFNVKVVAVPSTIDTGFALPPVEEFEKKITDKTRAIIICNPGNPSGYLYTREELQKLSEIALKHDIVVISDEVYREYVYDGQQQVSMFEFPELAENCIIIDSESKRYSMCGARIGCLITRSKKIHDAAMLFAQARLSPVLLGQIAATAAHRNDTAYILKVREEYTQRRNLLVELLNAIPGVVCPKPKGAFYCVAELPVEDSDEFAQWMLESYSHNNETVMVAPMSGFYSDPKLGKKQVRIAYVLKEADLRRSVELLNDALQKYKSGAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F2</accession>
    <name>C6X2F2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806899.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02179"/>
    <dbReference type="EnsemblBacteria" id="ACU08615">
        <property type="protein sequence ID" value="ACU08615"/>
        <property type="gene ID" value="FIC_02179"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02179"/>
    <dbReference type="eggNOG" id="COG3762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086382_1_1_10"/>
    <dbReference type="OMA" id="FWESTRD"/>
    <dbReference type="OrthoDB" id="1927539at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TPM_phosphatase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="142" mass="16007" checksum="B87E6225325A9575" modified="2009-09-22" version="1">MSNFLTEYQMASLVEAIQSAEDHSTGEIRVHIDSNSEGNNAEIAFGVFKALCQNKTAERNAVLFHINFEQHYLTIIGDEGIHAKVHQSFWDQIHDEVTAEFAKGNYHEGLRNAILKTGFELKKHFPVSGENPNELSNEITFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q1</accession>
    <name>C6X2Q1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806998.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02281"/>
    <dbReference type="EnsemblBacteria" id="ACU08714">
        <property type="protein sequence ID" value="ACU08714"/>
        <property type="gene ID" value="FIC_02281"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02281"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_10"/>
    <dbReference type="OMA" id="DKMFLDN"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="328"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="535"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="641" mass="73665" checksum="056DCC83E30B1E08" modified="2009-09-22" version="1">MLSVQGLGLHHSGNYLFQNVNFTIKKDDKIGLVGKNGAGKSTLLKMLTGEINFFEGSIVPEGNITIGFLKQDLDFVKGRTVWNETLQAFEQINAMKDELDEVNHQLVTRTDYESDSYENLIHKMTELNDLLMHHDAYNLEGDVEKVLLGLGFRADDFHKITDEFSGGWRMRIELAKLLLQKNDLMLLDEPTNHLDMESIIWLEDFLKDYPGAIVLVSHDKQFMTSVCNRTFDINNRKVDDYKANYTKYLELSKERKEKQAQAKKNQDVEIKQMEDNINRFRASATKSSFAQSLIKKLDKLERIEIDNDDVSKFNIRFVQSVVPGKVIFEAKNLGKAYGNKQVFDKVDFFIERGDRIALLGQNGQGKTTLAKILSGEIKDYSGEWNLGHNVNIGYFAQNQEEVLTPNKTVLEEAEDAATEETRPRVRDLLGSFLFQGDDVQKKTKVLSGGERNRLALCKLLLRPFNTLIMDEPTNHLDIQSKEIIKLALQKFEGTLILISHDREFLQGLSDKIFEFRDGRMKEFLGDVNEYLDFRQKESIREVSAEKSKLQELRNEPVVEKVVPKPVEVKPVIVSKDQKQIENKIKKVEEKISELETKIEEMEAKFTTENPSAEILETYNSKKEELDLALQEWEFLGTQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R1</accession>
    <name>C6X2R1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">FIC_02291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807008.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02291"/>
    <dbReference type="EnsemblBacteria" id="ACU08724">
        <property type="protein sequence ID" value="ACU08724"/>
        <property type="gene ID" value="FIC_02291"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02291"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_10"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="6"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU08724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="414" mass="44266" checksum="B6988361820A21FA" modified="2009-09-22" version="1">MELKRVVVTGFGAITPIGNNAKDYWENLVKGKSGAAPITLFDATQFKTKFACEVKNFNPLDHFDKKEAKKMDRNTQLGIVAAREAVEHSGIMDTDIDKNRVGVIWGSGIGGLETFEKEVLGWANTDIPRFNPFFIPKMIADITGGHISIEYGFHGPNYTTVSACASSANALIDAKMIIQLGKADVIVCGGSEAAVTASGMGGFNAMMALSTRNDDPTTASRPFDKDRDGFVLGEGAGTIILEEYEHAKKRGATIYAELKGGGMSADAYHMTAPHPEGKGAYLVMKNCLEDAGLSTDEVDHINMHGTSTPLGDIAESNAISKLLGDHAYDIQINSTKSMTGHLLGAAGVIEAIAAVHTIIHDIVPPTINHFTDDEAIDSRLNFTFHTAVKKVVNVAMSNTFGFGGHNACVLFAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R2</accession>
    <name>C6X2R2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ordered locus">FIC_02292</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807009.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02292"/>
    <dbReference type="EnsemblBacteria" id="ACU08725">
        <property type="protein sequence ID" value="ACU08725"/>
        <property type="gene ID" value="FIC_02292"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02292"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_0_10"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="OrthoDB" id="1890943at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="174"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="28997" checksum="D02D968B2E53F6F4" modified="2009-09-22" version="1">MELKKYIPKFLITKKNNLSEKDYILSNEISKITGCSVQNINLYREAFSLKTASPRTQVKNYERLEFLGDSVLGAIISCHLFSTYPHANEGYLTQMKSKIVNRKNLNKLGDELGLTGFLQNESPSTLSENTSGNLLEALIGALYLDVDYETCKKVVLERLLTPSEINKLENKIVSYKSLLLEWSQKKKEHIRYDTEQEMQAGKNVVFRSVIWINDRKVANATETSKKKAEEKAAQRAFYILNKKQSILENSKDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R7</accession>
    <name>C6X2R7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4173 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807014.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02297"/>
    <dbReference type="EnsemblBacteria" id="ACU08730">
        <property type="protein sequence ID" value="ACU08730"/>
        <property type="gene ID" value="FIC_02297"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02297"/>
    <dbReference type="eggNOG" id="ENOG502Z8CA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048248_0_0_10"/>
    <dbReference type="OMA" id="AFAWYGD"/>
    <dbReference type="OrthoDB" id="1307400at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="2">
        <location>
            <begin position="235"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="456" mass="52691" checksum="2BAE9CA9EC3DCC95" modified="2009-09-22" version="1">MKRHQLILLTTVLFITLFYGEDTGINVGILGVATALLTFFHTPETRRTRTFLILFVTTILSSVAFVWYGDFVSFLATFTSCFLLIFHSRNSSLKSILVIPVFAFNFVTFPVRVFRFDQWLPKANISESLKKLVASVLIPAGFVVVFFGVYSLGSAHFSSIFDLYRLDFNLWEFFALSCVGFFLAFNFWNFRIDNSLVTVNHKLKNDFSGSHSPKPTFSFLDFGAERKSGFISFAALNLLLIIFLTTFIYEQFFESAKTSAQLSAETHDRVNAVILSIIMAVLVIMFYFKGYFNFDPKARYLKIMAKIWIFLNVLLVVTAFTKNAEYFINLGFTYKRLGVFAFLILAFAGLLLTFIKIQRQKTNAFLINHIVWYFYGTVLVCSYFNWGGFITSQNLKRANFDLQYHHKSVNYNELQLLDYAGKERNLKLRQQILNQIESEKSKTFLSGTLFYQNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T1</accession>
    <name>C6X2T1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative cysteine ligase BshC</fullName>
            <ecNumber evidence="1">6.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bshC</name>
        <name evidence="2" type="ordered locus">FIC_02311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BshC family.</text>
    </comment>
    <dbReference type="EC" id="6.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807028.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02311"/>
    <dbReference type="EnsemblBacteria" id="ACU08744">
        <property type="protein sequence ID" value="ACU08744"/>
        <property type="gene ID" value="FIC_02311"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02311"/>
    <dbReference type="eggNOG" id="COG4365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022249_2_0_10"/>
    <dbReference type="OMA" id="TTGHQLN"/>
    <dbReference type="OrthoDB" id="295429at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01867">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011199">
        <property type="entry name" value="Bacillithiol_biosynth_BshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10079">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012535">
        <property type="entry name" value="UCP012535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03998">
        <property type="entry name" value="thiol_BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="528" mass="61174" checksum="BD51061ACE9CF27C" modified="2009-09-22" version="1">MEKHSTIPFVDIESIPQLIKDFLMQKIEGFGDHVFNTDHINRQFSHKEKSFTQEKRQLLSEVLRSQYSGLNLSEKQKINLEKLSDSQTYTVTTGHQLNLFTGPVFFIYKILQTIKLADHLNQTFPQRKTVPVFWMATEDHDFDEINHFNTRGNYYESKAEAGGSVGRIQPDDHFFIAEFEKEFTDSVYGTELILMMKRAYKKGSSLAQSTRILVHELFADYGLLVIDGDNAGLKSQMKAIFRGELLNSDLFETTKPTVSQLTERYGKVQVNPREINLFYLSETRDRIEFDREKYIIVDKNISFSKDEILTELENHPEKFSPNALMRPVYQELVLPNIAYIGGNAEIMYWLELKLYFEKLALPFPVLIPRNSMLFVSAKTLSKAGKLGLKMSDFFRNFAEVTKGIVLDGNEILTALEENETVLQAQFEKISDKAAMTDKSFGTLVQAEKTRQLKSYQRMKKRLLRAEKIKQHEKMERLNNLFLEIHPGKSWQERVLNFSVFYADHGHEWLQSCYDGINVSEAELIIVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T3</accession>
    <name>C6X2T3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807030.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02313"/>
    <dbReference type="EnsemblBacteria" id="ACU08746">
        <property type="protein sequence ID" value="ACU08746"/>
        <property type="gene ID" value="FIC_02313"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02313"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_5_10"/>
    <dbReference type="OMA" id="HAFFDYM"/>
    <dbReference type="OrthoDB" id="406005at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="377"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="509" mass="55737" checksum="0658F6757BC5B8D6" modified="2009-09-22" version="1">MKKFLIILSSVLLITASNSCRESELELFPPSQDDIQDINSEEKLQAFLNGGYLTMASVSAYGADAMAFGDVLSDNLYVTSAKAYVLTSNMNYSALNNDTGGLYRTMYDAIMNCNTVINNTQVADNPNVTRMKAEAKILRGFAYFTLLNYFSPAPTSGVNQEFGVPLVLGDYDASIQPARATVAEVYAQIISDLNDGVASADDQSTSATPKVFLTKTAARLILTRVYLTRRAAGDAQLALDHANYIINNSPSIYQPITKAEYVNYWMGTSDDFSENHPETIWELDLNPSSNLVTGVGANLALPTLYNRISGDRRALLFTKDFYDSFPHTDLATLPNGTPQSTSPDVRRGDTKTSAPALPAGLLSTLTLPLTDNPPGAWTNKYPRLSSTGNFNRNIKIFRFSEALLNRIEALHLVGQSATALAELNAFAVSRGGSTYTGTNLLNDILTEKSKEFYGEGQRFLDLKRHNLPLIKNSNCSLNCNVPANDKLFVMPISQSAINYNPNLKQYPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T8</accession>
    <name>C6X2T8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02318"/>
    <dbReference type="EnsemblBacteria" id="ACU08751">
        <property type="protein sequence ID" value="ACU08751"/>
        <property type="gene ID" value="FIC_02318"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02318"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OMA" id="PTWYGGW"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="62"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="385"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="978" mass="106781" checksum="2597CED0EDB65DBB" modified="2009-09-22" version="1">MLIKINIFADILLKSVNMNVKIKVLSIGVVFFAAQSLSAQQDSAKVQNIDEVIVVGYGTQRKSEVTGAISSIKAADIATIAAPSFEQQLAGRAAGVQVSTPSGVLGEAPRIRIRGIASLTSGLSPLIIVDGVPIWSGDIGGQTATNGLAEINPNDIESYEILKDGASTAIYGSRASNGVILITTKKGRGGRFNLNFSNYAGYASPAGLYDLLQTPDFITISNEKRANTASASTQTPIAFGTEYNTNWQKAVLRSAAFQTDNVLSASGSVGKSNYYTSLGYSNQEGVTRPNAMKRFTGRANVEHQAFDWLKIGTNLSFTKTQYEGLNTGTSSLSGNIFNAIRQLPNTPIYNPAHPTGYNIDLIDPRVVGRWQNTMLAGDNITNIMYTLDNNKYGSDVSRFIGSAFADVRLFPFLTYRLQASVDQSQTKGYVYWNPIHGDGQGSNGFIRNDLSDLLRNNVQNILTFDKTFGDNHNITLVGVNEIQKQKVQSFFGGGTNLSNVYFGSGVVSGSIGTLQAGGGITENGFVSLAGRLNYNFAQKYFIQASIRRDGLSSLPYANKYGNFPGVSAGWTVSKENFMESINPIVNDLKIRGSWAKVGNTDIGNYPYLGTFSNLKYADYNGIAYSQIGNDELRWESTKKIDVGVDLGMFSNKLRFTFDYYENQIDDIILGAPLSSDFGIPGNLIYKNIGTMVNKGLEFSADYNVFNTEKFSLDLNANFTTLENEVLSLANNNADMVGLNNISRVGESINSIWGFKYWGVNAANGNPVYYKADGSLVQGVVGGNRYAVFNQANPGDVSQTSSLSTSTDKMILGQSLPKYFGAAGLRFRYQQFDFGTTVRFSGGNKIFNSTRREMMNLNFTNNSTEILGRWQSPDNPGDGWTPRLFFGDNTFTNQSSNATSRFLEDGDYVKFDIMSLGYTFAPTTVQQVGIKSLRIYVQAQNAFIITKYTGLDPEMELNGVDFNATPRQRVFSMGFNISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X2</accession>
    <name>C6X2X2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02352"/>
    <dbReference type="EnsemblBacteria" id="ACU08785">
        <property type="protein sequence ID" value="ACU08785"/>
        <property type="gene ID" value="FIC_02352"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02352"/>
    <dbReference type="eggNOG" id="ENOG5033B9U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2193104_0_0_10"/>
    <dbReference type="OrthoDB" id="2067317at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="108" mass="11908" checksum="D55902A9D5BE8F81" modified="2009-09-22" version="1">MSQNSCEPQYISNSRVYAEGNISSVERADIAVKLFADDILISETVTNRDGNFALGGPGTSGEKTLYFNRKIISFNTSNKDCSLSYDSLSIILPAKNTSYKFPQIVLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X3</accession>
    <name>C6X2X3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807070.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02353"/>
    <dbReference type="EnsemblBacteria" id="ACU08786">
        <property type="protein sequence ID" value="ACU08786"/>
        <property type="gene ID" value="FIC_02353"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02353"/>
    <dbReference type="eggNOG" id="ENOG5033907">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1394522_0_0_10"/>
    <dbReference type="OrthoDB" id="1516949at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="1">
        <location>
            <begin position="9"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="195" mass="21679" checksum="FCEFA4F120E66982" modified="2009-09-22" version="1">MRTITIIFVFLSALSFAQDSKKFSVELKGNTFSGLGNNFIAEGTTTFTGFGLGLTGMVYNNFGLGIEFNRGYADVKDVSVFGELNNPELTLIDLYGLYRFPATSKLDIEGNVGAGNLRIKSRTDYRSDEFLESGSTFFLGGKLLYSITKNDQLHVVGGSRLYFLSTITEMDDPEIDEYYSKATLLNFSLGLRLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X302</accession>
    <name>C6X302_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rho</name>
        <name evidence="10" type="ordered locus">FIC_02382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02382"/>
    <dbReference type="EnsemblBacteria" id="ACU08815">
        <property type="protein sequence ID" value="ACU08815"/>
        <property type="gene ID" value="FIC_02382"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02382"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_1_2_10"/>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="9">
        <location>
            <begin position="159"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="277"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="289"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="526" mass="58680" checksum="F9B2D533DE9C054A" modified="2009-09-22" version="1">MKVTDEAAVEKPAEVATEPAAPDSEQQSEPVAPKAAEEQDANRNPQKKRRQRTPPVKTDSVSDEQAEETAPAVEAKTEQPRNQNPNQNSNQNQNQNPNQNGNQNGNSNANASQNPAKPQHPNQKNQHKNQNQNPNQNRNQQNTENQEEAAKKEFNFDGLVTIEGVLEILPDNYGFLRSPDFSYISSPDDVYVSTNQIRNYGLKTGDNVRGIVRLPKEGEKYFSLLKPTEVNGRDLEFIKDRVSFEFLTPLFPEEKFNLTGPNSTLSTRIVDLFTPIGKGQRAMIVAQPKTGKTMLLKDIANAISANHPEAYMMILLIDERPEEVTDMERSVNAEVIASTFDEPADKHVKVANLVLSKAQRMVECGHDVVILLDSITRLARAYNTVTPASGKILSGGVDANALHKPKRFFGAARNIEGGGSLTIIATALIDTGSKMDEVIFEEFKGTGNMELQLDRKIANKRIYPAIDLVSSSTRRDDLLLDETTMQRMWILRKYLADMNPVEAMEFVNKSIKGTRSNEEFLMSMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X306</accession>
    <name>C6X306_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein, MsbA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_02386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02386"/>
    <dbReference type="EnsemblBacteria" id="ACU08819">
        <property type="protein sequence ID" value="ACU08819"/>
        <property type="gene ID" value="FIC_02386"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02386"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_10"/>
    <dbReference type="OMA" id="WGTYLVK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="336"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="574" mass="63999" checksum="3A461778CABB9E1D" modified="2009-09-22" version="1">MLPILGLMFGTVDKVDTTTPPVNTGRLVDSFGYAKDWAYYNIQKNIEDYGTVKVLAVLCAVTAVAFLLRNIFRYLGSFLLVNYRVGITKDLRTAMYDKFLKLPVSFFTEKRKGDMMSRISNDIGGVENGIMGSLVDVINSPFMIISSLITLFILSPNLTLFSLLVFPLMGGLIAWVGKSLKKQATAAQEELGNLFSLVDETLKSSKVIKIFNADKILKNRFSTTTDNWQKYAIGMSRRRELASPMSEFLGSVTILIITWFAGVQILNEQTMEPETFLVFIGMFFQILDPAKKLSSAISNIQGGMASLDRVSEVLDYDLKVEEIANPHAISTLKDKIEFKNIGFNYDKDNVILKNFHLTIPKGKTVALVGQSGSGKTTIANLLARFYDVSEGEILVDGKNIKDLKLNDYRHLLGMVTQESVLFNDSVFNNILMGKADATEEEVMAAAKIANAHEFIEGLPEKYYTNIGDDGNKLSGGQKQRVSIARAVLKNPPIMILDEATSALDTESERFVQDALEKMMENRTSLVIAHRLSTIQKADWIVVMERGNIVEQGTHTELMNNNSVYRKLVELQNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X327</accession>
    <name>C6X327_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PMT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02407"/>
    <dbReference type="CAZy" id="GT83">
        <property type="family name" value="Glycosyltransferase Family 83"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08840">
        <property type="protein sequence ID" value="ACU08840"/>
        <property type="gene ID" value="FIC_02407"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02407"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019200_5_2_10"/>
    <dbReference type="OMA" id="DWITPWY"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="8">
        <location>
            <begin position="41"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="469" mass="54055" checksum="1594679D6A4A3892" modified="2009-09-22" version="1">MLKNTAMQKTEFYKSLTFYKVTLVVMIAARLVLNAVIPLMDQTEARYAEIARIMAETGNWVTPQIDYNTPFWAKPPLSTWLSALSIKIFGVNEFAVRFPSFVISILLIWLMKPFAARLNLNIVIPAFILFTVPEFLLHVGVVSTDMTLLLAVSLMMVSFWETVNDGRKIWGYLFFAAIGIGFLAKGPIILLLTGPPLVAWIVWFKAYRKVLFSFPCILGILIAAAVTLPWYYLAEMRTPGFLEYFFVGEHYKRFFDSSWTGDKYGFPKIQPFGIIWVFLYSLALPWIIFVTFKLIKFPSTILKDRWLLFLVLWLFWTPIFFTSSKSLIHTYILPCCFPLALFVATFWEDIRNKKTYVYTSLTVPVLSVVIILLAMIPGLFRNNTNTDKYLLENYKGENLFYLGEKTYSSQFYSEGRVKAVSPEKLDSIRIADKNALLIVRKRDSAQLDGKKFLIRQGEGRKSLLFKFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B7</accession>
    <name>C6X3B7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08930">
        <property type="protein sequence ID" value="ACU08930"/>
        <property type="gene ID" value="FIC_02497"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02497"/>
    <dbReference type="HOGENOM" id="CLU_3216571_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="44" mass="4957" checksum="7D4969323B4254A3" modified="2009-09-22" version="1">MPVATPAGKRLLIIYFLEDFNSDFDGKVKDFMLKGSVSFVFSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F3</accession>
    <name>C6X3F3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">JmjC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807250.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02536"/>
    <dbReference type="EnsemblBacteria" id="ACU08966">
        <property type="protein sequence ID" value="ACU08966"/>
        <property type="gene ID" value="FIC_02536"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02536"/>
    <dbReference type="eggNOG" id="COG2850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_3_3_10"/>
    <dbReference type="OMA" id="PLYDDRP"/>
    <dbReference type="OrthoDB" id="1885303at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="91"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="293" mass="34345" checksum="47C8C38B6E5E4FE9" modified="2009-09-22" version="1">MGLHLTPIDVVDDITDEDFRKKYLKPRKPVVIRNMAKNWPAYQKWTMDYMKETVGNVEVPLYDSSKADPSAPINSSAAKMNFSDYIDLIQNEPTDLRIFLFDPIKSAPKLLEDYIAPKELMGGFLDKYPNMFFGGKGSVTFLHYDIDMAHIFHTHFNGRKHILLFDNKWKDRLYKLPMATYALEDYDISNPDFEKFPALEGVEGIECFLEHGDTLFMPTGYWHWMKYLDGSFSISLRAWDKSWAVKAQSIWNLTVQRNLDNFMKRNFKEKYMNWKEKTAVERADFALKKGLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H7</accession>
    <name>C6X3H7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ordered locus">FIC_02560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807274.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02560"/>
    <dbReference type="EnsemblBacteria" id="ACU08990">
        <property type="protein sequence ID" value="ACU08990"/>
        <property type="gene ID" value="FIC_02560"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02560"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_1_0_10"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:tRNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with target base in tRNA" evidence="7">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="346"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="395" mass="44387" checksum="CF5475D73B22B006" modified="2009-09-22" version="1">MKIVVGLSGGVDSSVAAYLLQKQGHEVVALFMRNWNDASVTLEDECPWIEDSNDALMVAQKLGIPFQVIDMSELYKEKIVDYMFAEYEKGRTPNPDVLCNREVKFDVFMKTALSLGAEKVATGHYARVDSTVDENGNEMFHLLAGKDNNKDQSYFLCQLSQDQLSKSLFPIGELTKPEVREIAKEIGLVTADKKDSQGLCFIGKVSLPTFLQQQLKPKEGKIVEIFKDFPELTAEKPQFATKLEELKFLSTKNSYQESDGKIIGKHQGAHYFTIGQSKGLGIGGHKESCFIISRDMPTNTIFVGEGKNFPGLYQTALKIDPSEIHWVREDLRLLNGETMKVQARIRYRQALEEATLYQFEEGLFIEFENPQSAVAEGQFAAWYMEDELLGSGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L0</accession>
    <name>C6X3L0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="16">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="16">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">metG</name>
        <name evidence="20" type="ordered locus">FIC_00540</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 16">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="16"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782145.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00540"/>
    <dbReference type="EnsemblBacteria" id="ACU06998">
        <property type="protein sequence ID" value="ACU06998"/>
        <property type="gene ID" value="FIC_00540"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00540"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_10"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 16 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="12 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16 17" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="19">
        <location>
            <begin position="576"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="16">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="16">
        <location>
            <begin position="333"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ACU06998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="677" mass="76951" checksum="3BA3EA4FED762116" modified="2009-09-22" version="1">MSERKMITAALPYANGPVHIGHLAGVYIPADVYARFQRRLGRDVAFICGSDEHGIPITIRAKKEGVTPQDIVDKYHEIIKKSFADLGISFDEYSRTTSKKHYEVSQDFFATLFNKGKFAEEVSEQYFDEQAGEFLADRYIVGTCPNCSNDNAYGDQCEKCGSTLSPSELINPKSMLSGNVPILKETKNWYLPLNEYENFLNEWIIEGHKNDWKPNVYGQVKSWLTDGLKSRAMTRDLNWGVPVPLPDAEGKVLYVWFDAPIGYISFTQEWAEKNGKDWKDYWQNENSDLVHFIGKDNIVFHCIIFPAMMKAHGDYKMPTNVPAFEFLNLENDKISTSRNWAVWAHEYVEEFPGQQDVLRYALLSSAPETKDNNFTWKDFQTKNNSELVGIFGNFINRVAVLIHKYYDGIVPQGNEQAPELHEISKAASEIESYLERYEFRNALSSMMNLARFGNQFLQTEEPWKTIKDNPEKAANSLFIGAQIAVGLAQICEPFLPFSSDKLLKMFNVSQLSWKEIANQQILIKTGHQINTAELLFSKIEDETIDFQIQKLENTKNSNKKTNPNAKPMKDEIQFDDFTKIDLRTATILTAEKVEKADKLLKFSVDTGVDVRTVVSGIAESFTPEECIGKQVMILLNLAPRKIRGIESQGMLLLTTKPDGKLAFVTPEETVENGIEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M7</accession>
    <name>C6X3M7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782162.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07015">
        <property type="protein sequence ID" value="ACU07015"/>
        <property type="gene ID" value="FIC_00557"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00557"/>
    <dbReference type="eggNOG" id="ENOG503489R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260393_0_0_10"/>
    <dbReference type="OMA" id="PAYQEIN"/>
    <dbReference type="OrthoDB" id="1593565at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24760" checksum="70869BBA4D4FB7F7" modified="2009-09-22" version="1">MKSLQIPLLLLIISCTDKKETRMPLPQDKATQHDVKQPIKKQDSALASWLEYYQNENPTFAEKNFILTGTSQLAYNPSNVVVMNTKGFNEIYRPFFVFNESRTNYLDFDSYHWSVAKDGNASFNPDQQVALVDMKKKTAVQIAFFGPSYTVEEAYWRGDSAAVLLGNSYEQVPFMMKFIFKKNTVQHYQYPDTLKFDQPYYRVRLQNLGIKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q6</accession>
    <name>C6X3Q6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00589"/>
    <dbReference type="EnsemblBacteria" id="ACU07044">
        <property type="protein sequence ID" value="ACU07044"/>
        <property type="gene ID" value="FIC_00589"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00589"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069570_0_0_10"/>
    <dbReference type="OMA" id="QTFAAYE"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="139"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="325" mass="36806" checksum="3628B486857F9121" modified="2009-09-22" version="1">MQGKSVNIMFGKKLMMSRLFKITLILVALVAVVQCKKENTQIVEEPVVPKDSAIQAENPKPEISYKPFVFPEDNKDSAMAVFNKQYSEEEQYTILALNRLDSKNKWRADTLAVPDQFDHTLMSYSPFPDNLQILADVNKFVLFSYPIQAYALYEKGRLVKWGPTSMGKKSAQTKQGLMFGNWKKELAISTVDSEWKLPYNFNVHNTLGIGWHQYDLPGFPASHSCLRLLMDDAKFLYKWADQWVLDEKGTSRIATGTSVIVFGEYNWGGKKPWKNLLDDPAANDVSVTVLHAVIEPHLAEIMEEQANREEVLAQKSAVKIAKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R2</accession>
    <name>C6X3R2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dihydrodipicolinate reductase</fullName>
            <ecNumber evidence="10">1.17.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782197.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00595"/>
    <dbReference type="EnsemblBacteria" id="ACU07050">
        <property type="protein sequence ID" value="ACU07050"/>
        <property type="gene ID" value="FIC_00595"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00595"/>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_2_0_10"/>
    <dbReference type="OMA" id="KHESITR"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="9">
        <location>
            <begin position="137"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="27877" checksum="E26F962010751745" modified="2009-09-22" version="1">MKIGLLGFGKTGKAVAAVILQNKEFSLEWVYRKRPLLEGRNVPEFLGVESDHPGRVYSAATIEMPDLLDQHPVDIIIDFSSETGIYIYGETAAERGIKIISAVSHYGDEEKSLLKKLGEKTVVFWSPNITLGVNYLLFAAQFLKKIAPWVDIEINEEHFKEKIGTSGTAVKLAKALELPEEHINSVRAGGIVGKHEVIFGFPFQTVRLIHESISREAFGNGVVFVAQNLKNKDAGLYKFEDILLPYFSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V0</accession>
    <name>C6X3V0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782234.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00633"/>
    <dbReference type="EnsemblBacteria" id="ACU07088">
        <property type="protein sequence ID" value="ACU07088"/>
        <property type="gene ID" value="FIC_00633"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00633"/>
    <dbReference type="HOGENOM" id="CLU_1553026_0_0_10"/>
    <dbReference type="OrthoDB" id="2163435at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="19972" checksum="B217EFC0ABA79C20" modified="2009-09-22" version="1">MKTIEKILLIVILEIIIFWILVRYYYLPKLYSNPDVITAQNLIIITVIINVIIFGILYFTKKTKFKNAFLANIILAPIILLLVLSKAHKTFRQENFSSGSFQYKGSKFSVFVDKKKNNFTIFKTDINTNETNIIAGDIELQNDKILLKSRNEEYLIENDTIKGIEGKNFKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z0</accession>
    <name>C6X3Z0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00673"/>
    <dbReference type="EnsemblBacteria" id="ACU07128">
        <property type="protein sequence ID" value="ACU07128"/>
        <property type="gene ID" value="FIC_00673"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00673"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134960_1_0_10"/>
    <dbReference type="OMA" id="YRADFIC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="151" mass="17519" checksum="635093669364A5EF" modified="2009-09-22" version="1">MFLTTEIRRLSRRTLRNQISNFAMHENEISQMVFDAGLKVHRNLGPGLLESAYEECLYYELLKTGLYIEKQKAMPLIYEDVKMDVGYRLDFLIESKVVVEIKSVETLNDVHLAQVLTYLKLSKCKLGLLINFNVNLFKIGYRRILNGDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X407</accession>
    <name>C6X407_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782291.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00690"/>
    <dbReference type="EnsemblBacteria" id="ACU07145">
        <property type="protein sequence ID" value="ACU07145"/>
        <property type="gene ID" value="FIC_00690"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00690"/>
    <dbReference type="eggNOG" id="ENOG50332J1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2648767_0_0_10"/>
    <dbReference type="OMA" id="FKWSFGF"/>
    <dbReference type="OrthoDB" id="1858724at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="76" mass="9086" checksum="2D3452FA044AB53F" modified="2009-09-22" version="1">MTSFFLFLSDVFRWTFGIFDAFGYIFNWILFLVGSALFTYWCWVLVSRLGNNRDKEYVSPTEGKHPYYDPAIHKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X409</accession>
    <name>C6X409_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782293.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00692"/>
    <dbReference type="EnsemblBacteria" id="ACU07147">
        <property type="protein sequence ID" value="ACU07147"/>
        <property type="gene ID" value="FIC_00692"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00692"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_2_10"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="22640" checksum="AFC13E67386AC3B8" modified="2009-09-22" version="1">MKIICIGRNYAAHAHELGNEIPDNPVIFMKPDSAVLKKGSDFYIPEFSDDIHYELEVVLKISKGGKYIQEEKASNYYEEIGLGIDFTARDLQSNLKAKGLPWELAKGFDGSAVVSDFYKKADFNMKNLNFSLLKNTEKVQDGNTSMMIFSPEKIIAFVSKYLTLKAGDLIFTGTPEGVGKVAENDILQGFLEDQKLLDLRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X462</accession>
    <name>C6X462_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="9" type="ordered locus">FIC_00745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782346.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00745"/>
    <dbReference type="EnsemblBacteria" id="ACU07200">
        <property type="protein sequence ID" value="ACU07200"/>
        <property type="gene ID" value="FIC_00745"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00745"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_4_1_10"/>
    <dbReference type="OMA" id="MSPVIAW"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="192" mass="21508" checksum="2A3A08BFC3E7B21A" modified="2009-09-22" version="1">MINIVLFGPPGSGKGTQAQHLIEKYNLKQISTGDLFRFNMKNDTALGKMAKSFIDKGHLVPDEVTTEMLIDEVKKTTGTNGFIFDGYPRTVNQTEALEEIVKTELGTEISVCLSLIVDDEILVERLLKRGQTSGRTDDSNEEIIRNRIKEYYAKTAEVAELYKQQGKYVEVNGVGEIDEISAKLFAEVEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C4</accession>
    <name>C6X4C4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782408.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00809"/>
    <dbReference type="EnsemblBacteria" id="ACU07262">
        <property type="protein sequence ID" value="ACU07262"/>
        <property type="gene ID" value="FIC_00809"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00809"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058958_0_0_10"/>
    <dbReference type="OMA" id="YMGGVEY"/>
    <dbReference type="OrthoDB" id="951626at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972294" evidence="1">
        <location>
            <begin position="20"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="386" mass="44483" checksum="1559C553E42A7DDD" modified="2009-09-22" version="1">MKKYISVALASLFSLGVYAQDSNTNIEAESKISSLERHNDQLNIYFHIQSSFDAVSKDGGETEMAFKARQFRLEIKGNLTDKLFYRFRQRLNKDTNPQSLDNLGKATDYMYVGYKATDKITLITGKQRQAWGGFEFDLNAINVHEYADFIGAMDNSMMGGAIIYTPVKDQEFQFQITNNRNSYLEDIYGDLSAQGIEQSQSPLAYIVNWNGSFLNKMFQTRWAYGIQTEAKDNYSTMLTMGTKFNLKQFQLTFDFMNADEKLDRLGIATKAGAEWLAANNRKIFQNVTYNTLILKAEYQPKPEWNIFAKGMYETTSVEGVENYDDDFRKAYGYMGGVEYLPFKDQDLRVFLAYIGRKYVYTEAIPSLHDYHTDRVSLGVMYRIKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E2</accession>
    <name>C6X4E2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF</name>
        <name evidence="14" type="ordered locus">FIC_00827</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782426.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00827"/>
    <dbReference type="EnsemblBacteria" id="ACU07280">
        <property type="protein sequence ID" value="ACU07280"/>
        <property type="gene ID" value="FIC_00827"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00827"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_4_1_10"/>
    <dbReference type="OMA" id="FAWKPIL"/>
    <dbReference type="OrthoDB" id="1999641at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU07280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="165" mass="18439" checksum="19DB5F7C7A556CB5" modified="2009-09-22" version="1">MGLLEDFSSGLFIIQSVIFLILLLVLRKLAWKPIMDAVNEREVTIVDSLNQAKLAKQEVLNLKAENEIIIREAKAERDNILKEAREIKERIVGEAKDMAKVEGDKMIEQARQSIQAEKAAAMSDIKNQIGVLSVNIAETILKEKLNTDGAQNALVENMLNKSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H8</accession>
    <name>C6X4H8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782462.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00863"/>
    <dbReference type="EnsemblBacteria" id="ACU07316">
        <property type="protein sequence ID" value="ACU07316"/>
        <property type="gene ID" value="FIC_00863"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00863"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642056_0_0_10"/>
    <dbReference type="OMA" id="CYAISEE"/>
    <dbReference type="OrthoDB" id="832149at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="465" mass="53515" checksum="0562906D0D9C476E" modified="2009-09-22" version="1">MRSHIQLSAARNYFLGFATSGAILLSGLYYFNSKTPQTPPPAVDEKVEYISAELTKIQDFDPNELTQSQWKNLGFSERQVATIMKYKQVVGGSFKSKEQLKKCYAISEEKFAQLEPHILLPEQNSGSNQRFANYNTSYNNFTPRNRANTALNIPGKFNPDHFTAQDFERVGFSARQSSSIIKYKNYLGGSFISKEKFKECYMISEENYRQLEPYILLPESAPASASAQYNGRSAKEKTGVNYQKFDPNLTDLEGWRALGFSEKQAQVIINYRERNLKGSFKTLEDIERCFVISPEKFAEMKPYIVLNPENFVSADPKKNSSQTTFTSSSGDEPKTDFSKVDLNQITYKQLLEFGFDEKSAAMMLGFRKKLGGFVNKQQIIDTYDIDKSMAQKLVSTARLDDSKVARYTLSDAPEDWLKNHPYFKYSADKIIFYRITNPDDRKIWKFLKVKPEYETRMRMYLKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I2</accession>
    <name>C6X4I2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SSU ribosomal protein S1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782466.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00867"/>
    <dbReference type="EnsemblBacteria" id="ACU07320">
        <property type="protein sequence ID" value="ACU07320"/>
        <property type="gene ID" value="FIC_00867"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00867"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_2_0_10"/>
    <dbReference type="OMA" id="SLNEFRY"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="223"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="395"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="482"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="597" mass="66820" checksum="69F85EDD1BF1CBFF" modified="2009-09-22" version="1">MSETTDKAEVLLNQNVAPEQFDWDSFESGLDADARKEKSDLEEIYNGSLNNLRDNDVLVGRVVRLTDKEAIVDINFKSEGVISLNEFRYNQGLAVGDEVEVMVDRREDKSGQLQLSHKKARTLKAWDRVNELHETGEIVNGFVKSRTKGGMIVDVHGIEAFLPGSQIDVKPIKDYDQFVGKTMEFKVVKINPEFKNVVVSHKALIEADLEGQKREIIGQLEKGQVLEGTVKNITSYGVFVDLGGVDGLIHITDLSWSRVNHPSEILSDGETVKVVILDFDDEKTRIQLGMKQLEAHPWDALSADMKIGDRVKGKVVVLADYGAFVEVAPGVEGLIHVSEMSWSTHLRSAGDFVKVGDEVEAEVLTLDREDRKISLGMKQLSQDPWSNIESKYPVQSKHVGTVRNFTNFGVFVELEEGIDGLIYISDLSWTKKIKHPSEFCAVGDKLDVIVLELDTAARRLSLGHKQLLENPWDKFESKYAEGTVHAGKTTEVFDKGAQVQFEDAEVEAFCPSRLLEKEDGSKIKKGEDAQFKVIEFNKEFKRVVVSHTATFRDEERKNVKDNSSSRSQTSSSSNNEEKSTLGDLDVLAELKKKMEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4J5</accession>
    <name>C6X4J5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00880"/>
    <dbReference type="EnsemblBacteria" id="ACU07333">
        <property type="protein sequence ID" value="ACU07333"/>
        <property type="gene ID" value="FIC_00880"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00880"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_10"/>
    <dbReference type="OMA" id="MVPNYNP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="379" mass="42001" checksum="7609310D1956DFA0" modified="2009-09-22" version="1">MKLFDVYPLMPVNIVKAKNCKLWDENGTEYLDFYGGHAVISVGHTHPHYVEKIKNQLDNIGFYSNSVINKLQEELADKLGKISGYEDYSLFLCNSGAEANENALKIASFTSGKKKFITFKNAFHGRTSAVVAATDDPSIVAPVNETCNFIFCEWNNVEQFEQLFFKNLPDLAGVIIEGIQGIAGIQIPSQKLMNKISELCSKNSVYFISDEIQSGYARSGKFFAHQYFGVKPDIITTAKGMANGFPIGGVLVSPKIPAKYKMLGTTFGGNHLACAAAVAVLEIIQNENLIEESFRKGEYLTKKLNEIPQIKEIRGKGLLVGIDFEISAAQVSKRLREQFKIFVGSASNPLTMRLLPPLTISYNEMDYFISSLKSVLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q8</accession>
    <name>C6X4Q8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782542.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00945"/>
    <dbReference type="EnsemblBacteria" id="ACU07396">
        <property type="protein sequence ID" value="ACU07396"/>
        <property type="gene ID" value="FIC_00945"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00945"/>
    <dbReference type="eggNOG" id="ENOG5032YWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_10"/>
    <dbReference type="OMA" id="QIRFLYY"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="120" mass="13732" checksum="8E230D7ACFA94705" modified="2009-09-22" version="1">MKTQRLRDLLIWQKSMVLVKDIYLLTENITASENHGLVSQIRRSAVSIPSNIAEGAGRNNPKEFYQFLGIANGSSYELETQLLLLVELNFKSEIEIQPLLNVLMEIQKMIYKFKTSLMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T5</accession>
    <name>C6X4T5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782569.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00972"/>
    <dbReference type="EnsemblBacteria" id="ACU07423">
        <property type="protein sequence ID" value="ACU07423"/>
        <property type="gene ID" value="FIC_00972"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00972"/>
    <dbReference type="HOGENOM" id="CLU_1793604_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="144" mass="16087" checksum="E15D1CC4C4C4CF05" modified="2009-09-22" version="1">MKFLHYILLAVFLGGCSSAQNHRLIDSSHTVSLGGVKGARSEKFDISVKENPQLDVKYLLVGDVKIPLNKTHKDGNVHLTGVYFPEVQPTVDLNNTKTRTPVYDAEKVFLVSQVKDTQKLIHQKISFKKESGKEDSIPLEDVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T8</accession>
    <name>C6X4T8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-binding proteins-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782572.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00975"/>
    <dbReference type="EnsemblBacteria" id="ACU07426">
        <property type="protein sequence ID" value="ACU07426"/>
        <property type="gene ID" value="FIC_00975"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00975"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_3_10"/>
    <dbReference type="OMA" id="EWGRLFM"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="191" mass="22220" checksum="BA19C8A157BAB604" modified="2009-09-22" version="1">MHDSLKYIYSHFLLSTENVEEIIAAHDEVHVTKGSFLLNEGETANEYFILEKGLVRAFVIDTDGNEITTEFFTENEIVIIPTSLFQKIPSQENLQAISDCTLWKISYDGFQRLFHQLEGLREWGRVWFSFQLFTMKQRSLDMITQSASERYLKLMKEKPAIIHYAPLKQIASYLGITDTSLSRIRKELSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U1</accession>
    <name>C6X4U1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhnB protein putative DNA binding 3-demethylubiquinone-9 3-methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782575.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00978"/>
    <dbReference type="EnsemblBacteria" id="ACU07429">
        <property type="protein sequence ID" value="ACU07429"/>
        <property type="gene ID" value="FIC_00978"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00978"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_17_2_10"/>
    <dbReference type="OMA" id="WGDYFGS"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="142" mass="16067" checksum="51F8EFE60DAA1A4A" modified="2009-09-22" version="1">MSKLNPYLNFDGTAEEAFNFYRSVLGGEFEGEIMRMDAAPGTENLSDEMKSRVLHISLPVGENLLMGSDIIPEFGQKLMPGNTNYISLFPDSRAEADRIFAALSEGGEVEMPLEDQFWGDYFGSFQDRFGIFWMINYNEAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U2</accession>
    <name>C6X4U2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein containing DUF704</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782576.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00979"/>
    <dbReference type="EnsemblBacteria" id="ACU07430">
        <property type="protein sequence ID" value="ACU07430"/>
        <property type="gene ID" value="FIC_00979"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00979"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_1_0_10"/>
    <dbReference type="OMA" id="ENDLRVG"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="139" mass="16399" checksum="ADC2461E495150F2" modified="2009-09-22" version="1">MEPIKIEITILEPVKKVWDLMNDPKHIVKWNYATDTWHCTKAENDLRVGGKLMARMEAKDKSFGFDYVGIYEEILPHKLIRYRLDDGRTVEIVFNEVDASTTQVIETFEPETQNSREMQRDGWYAILNNFHKYAEDNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V4</accession>
    <name>C6X4V4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782588.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07442">
        <property type="protein sequence ID" value="ACU07442"/>
        <property type="gene ID" value="FIC_00991"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00991"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474682_0_0_10"/>
    <dbReference type="OMA" id="THINEQF"/>
    <dbReference type="OrthoDB" id="1742890at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="596" mass="68300" checksum="1D1E67143C44E9E6" modified="2009-09-22" version="1">MEKKYFDLHLHPIFKNFISKYEALVPLPNRKYDELAQPIRMSNAITNILDEVFIHILKSQSSISQCLQGNLTYAVASIVNLEHGFADSRGFFGNILKSKFSNPLDKTYFDKVRSGEVSYYRLMLMELNLYKQLRDYKDSPVAVLSRNFSRKPATKALNILISLEGSHNFSKLMVGNPLKTDFVPNRFVDLKKTIKLSQVADNLWREMIVDTDAGESPDMHHSQSAAVNFERFYKSLARENMDLLYLTLTHLTHINEQFLATHAFGMKMLKHPSFYPFGNGITGSGFDVIEKCYSMRNHKDQHRPILVDMKHLGLKSRQDYYAFRKNLIKTEGKYAQIPIIASHIGVTGFTYNEWKNALKRESCTVYNYEGARAVSIEMTRKNCGRWGSFVNNDFTFNPWSINLMDEDIVEVLNSDGILGMSLDVRILGFQSEYGLNLSSENEFLSTADFQTHFPQIVVKNLPVNTMETMISENESWLIPTKEDRHPLAFCFNIIHVIQVGLLKTDIEEPWKQICLGSDFDGLIEPLNISPDVTSLEELEANIIKWIVVAEKAYVKENGGSCVLSEFKSAQLKSVVRGIMFENGKNFVERWLNNFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X519</accession>
    <name>C6X519_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable oxidoreductase</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805792.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01057"/>
    <dbReference type="EnsemblBacteria" id="ACU07507">
        <property type="protein sequence ID" value="ACU07507"/>
        <property type="gene ID" value="FIC_01057"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01057"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_15_1_10"/>
    <dbReference type="OMA" id="EQDAYLY"/>
    <dbReference type="OrthoDB" id="1087129at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03477">
        <property type="entry name" value="Rieske_YhfW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038010">
        <property type="entry name" value="YhfW_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="418"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="503" mass="56007" checksum="74757DF08EBDF632" modified="2009-09-22" version="1">MNRDGLNQSIWENALFPHHNKEFSPKSFDTIIVGAGITGISLGLELQKSGRDCLILEQKNIGFGTTGGTTAFINNFFDESYDRLISSFGEDKAQTIADNAMKAPEIVRRNVSDYNISCDFAECKFYLFSAEKKQDRQLEKILDAHQRLDVPSRSVSDIPFDIEFRTAIEIDGQAQFHPVKYITALAEAFESLGGVILTDTRVSKDDKKEGLIVIETENGETFTAKNLVWATHIPPGLNRFSTLCAPYRSYALAAKINHAPTAMAQAADLYDAYHYIRYHQSGDENFLIVGGFDHKTGHEDETEKPFDDLVYYTEENFQFEEIVSKWSAQFYVPVDGLPYIGKMPGESNIFVATGYNGNGMTWGTLAAEILSDVIDGKENELADIVAPGRIEVQASAKEFIKENADAVFHLIKDQFTADKKTELEELKPGEGKVIEHDSQKVAAYRQENGELELVTAICPHMGCVVNFNNSEQTWDCPCHGSRFDTKGNLLTGPSLTGLKPLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X554</accession>
    <name>C6X554_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prophage LambdaCh01, nuclease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01092"/>
    <dbReference type="EnsemblBacteria" id="ACU07542">
        <property type="protein sequence ID" value="ACU07542"/>
        <property type="gene ID" value="FIC_01092"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01092"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1213153_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="97"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="232" mass="26897" checksum="E90E6FC1246D4F95" modified="2009-09-22" version="1">MKKKGTKDLSSRLFPKQKILIKSASIDMSIHKINFKLLYLTVFIIFTFCQSKSETEIIRRSDRSPGLAAQSVETREKDFRQSEKTVGNPTPASTETTKTPYLVYKVVDGDTFWMRDQNNLETKVRLIGIDGPETRNTRKKKKGYYGNEAKVYLQSLILDRYVFIEQDVRSRDQYGRLLAYVYTENNLFVNADLIANGYAVIMSVPPNVKHQDEFFNLQQQARKNRAGMWGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X593</accession>
    <name>C6X593_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lead, cadmium, zinc and mercury transporting ATPase</fullName>
            <ecNumber evidence="8">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805866.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01131"/>
    <dbReference type="EnsemblBacteria" id="ACU07581">
        <property type="protein sequence ID" value="ACU07581"/>
        <property type="gene ID" value="FIC_01131"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01131"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_2_10"/>
    <dbReference type="OMA" id="FAQPWET"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="697" mass="75520" checksum="20E8D0556F368148" modified="2009-09-22" version="1">MEHKHRYDKDGKQICCTEEGKINAVADRRLTEELGDKACCAVDAKINPSKGKHPDKDSHKPADKHTDDDGHDHSAQGKSAFQLFLPAMISFVILIAGLAMDYLIPQSWFSDWVRIGWYAAAYLPVGLPVLKEAIESIRKADVFSEFFLMSIATTGAFAIGEYPEGVAVMLFYSVGEVFQTLAVQRAKGNIAQLLDQRPDEVTLLVDNRPQTVKAAEVALGSLIQLKPGEKLALDGVLISDSAPFNTSALTGESKPDTKQKGDTVLAGMINLNTVAQVRVDTPYSDSKLSKILELVQNATAQKAPTELFIRKFARIYTPIVVLLAVAICLLPYFFVDEYVLRDWLYRGLLFLVISCPCALVISIPLGYFGGIGAASRNGILFKGSNFLDALAGVKNVVMDKTGTMTEGVFKVQTVNIKPEFDKDLILKLVNVIENSSTHPVATAIHDHLGEPDHTVIFDHVEEIAGHGMKGTYQGKQLLAGNFKLMDRFNISYDVNPADIAETVIAIAYEGKFAGYITIADRIKEDAAETIQKLKSLGIKTTMLSGDKSTVVKAVAEKLGIQDAFGDLLPEDKVNRLKVIRGRGETVAFVGDGVNDAPVVALSDVGIAMGGLGSDATIETADVVIQDDKPSRIPMAINIGKQTKKIVWQNIALAFGVKAIVLVLGAGGLATMWEAVFADVGVALLAILNAVRIQKMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X598</accession>
    <name>C6X598_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01136"/>
    <dbReference type="EnsemblBacteria" id="ACU07586">
        <property type="protein sequence ID" value="ACU07586"/>
        <property type="gene ID" value="FIC_01136"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01136"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_10"/>
    <dbReference type="OMA" id="LDKYATH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="226" mass="25382" checksum="3F8CD677813067FD" modified="2009-09-22" version="1">MKMNKASDKIRILIVDDHQLMIEGLKSLLEDEDSISFVAGATTMKETLDFLAEHEIDVILMDVNMPDSSGIEITKKVRALYPHPKVIALTMHEDISIISKMIKAGASGYVLKRTNMHEVIDALKTVHQNGRYLSTSVQNVIMDNLMLPEDLMDAKDDNKPVLSGRELEVLKLIAKEFSNEQIGEQLFISERTVEAHRRNIFMKTKTKSIVGLIKYAITEGIVSIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C0</accession>
    <name>C6X5C0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07608">
        <property type="protein sequence ID" value="ACU07608"/>
        <property type="gene ID" value="FIC_01158"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01158"/>
    <dbReference type="HOGENOM" id="CLU_1254395_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="220" mass="25549" checksum="4D3EF05DE4474AA8" modified="2009-09-22" version="1">MRHCVDHFLVMKYILKIQRAAFAVFEPFLGGLVAADVEVPGGFGDVFEILGWVDENFTGPSAFECLRHRNKHRFFNRVIAFSGKLGGKIFIRDSFEEVKMADFAAEFYELPEGFGFWIRHAREIDLEEFFIGFAVIWRMQHGVNIIEQIDGCKAGFVLIADFTAVCETYVAFGFFFGDEFETQFVRNFLDYFRIEVGETFHIAVRCSNINNRIILWHFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S4</accession>
    <name>C6X5S4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsgA/CsgB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01314"/>
    <dbReference type="EnsemblBacteria" id="ACU07762">
        <property type="protein sequence ID" value="ACU07762"/>
        <property type="gene ID" value="FIC_01314"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01314"/>
    <dbReference type="eggNOG" id="ENOG5030D2R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821124_0_0_10"/>
    <dbReference type="OMA" id="QTWRANT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009742">
        <property type="entry name" value="Curlin_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07012">
        <property type="entry name" value="Curlin_rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970712" evidence="4">
        <location>
            <begin position="44"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="294" mass="31887" checksum="8CC5998C8041A914" modified="2009-09-22" version="1">MGGGVYPNRATFGIQTNQNFLTMKKLLSSAFALLAVGFAYSQANNDVSTQVGDDNTATINQTGWLNFNVLDQFGDDNVATVDQDGWFNENEALSQGNNNSIDVDQVGTWNFNTTEQYGNGNDAQTDQNGLLNEVVQLQDGNNNDTYAMQDGTGNYADQWQEGNGNDASSEQDGNGNEVYQDQDGNNNDAIAVQDGNLNYTHQLQVGNGNYAIHEQDGNLNYADAHQTGNNNDAIGWQDGNGNTIWQYQTGNGNTADDWQVGDGNTADITQNGTNHYHYGTQVGNGNMMTVTQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z8</accession>
    <name>C6X5Z8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione synthase/Ribosomal protein S6 modification enzyme (Glutaminyl transferase)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806121.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01388"/>
    <dbReference type="EnsemblBacteria" id="ACU07836">
        <property type="protein sequence ID" value="ACU07836"/>
        <property type="gene ID" value="FIC_01388"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01388"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048863_0_0_10"/>
    <dbReference type="OMA" id="INNPFWW"/>
    <dbReference type="OrthoDB" id="407111at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="93"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="317" mass="36498" checksum="54B9C5C74EC7844F" modified="2009-09-22" version="1">MAKKVGILFGMEDTFPWAFIDKVNELGKGKVIAEPVMIDKLEQGADYGYAVIIDRISQDVPFYRAYLKNAALNGTYVVNNPFWWSADEKFFNNALMSKLGIPLPKTVLLPSNDRPANTTETSFRNLKFPLDWGYIFDYIGFPAYMKPHDGGGWKSVYRVENPEDMWHKLGETEELVMMLQEEIVFDDYYRVYCLGKKYVHIMPYEPRNEHHLRYATTHQTEGKELEKLLKIIHDYTIKMNEALGYDFNTVEFAVRDGIPIAIDFCNPAPDADLKSVGEENFAWIVEHAAKFAIEKANEYKPGKTNISWGTFVKNGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X603</accession>
    <name>C6X603_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative K(+)-stimulated pyrophosphate-energized sodium pump</fullName>
            <ecNumber evidence="9">7.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound sodium-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">Na(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="12" type="ordered locus">FIC_01393</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:57884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Requires K(+) for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806126.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01393"/>
    <dbReference type="EnsemblBacteria" id="ACU07841">
        <property type="protein sequence ID" value="ACU07841"/>
        <property type="gene ID" value="FIC_01393"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01393"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008743_2_1_10"/>
    <dbReference type="OMA" id="MATTAMQ"/>
    <dbReference type="OrthoDB" id="98036at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="11">
        <location>
            <begin position="795"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium dependence" evidence="9">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="912" mass="96096" checksum="39C2EE2FA07D382B" modified="2009-09-22" version="1">MNLFLLVPLFGIIALIYTFIQSSWVNKQNAGNDRMREIAGYISDGAMAFLKAEYKIMMYFVVIVAVLLALMGASNANSHWSIGLAFVFGAFLSALAGFIGMKIATKANVRTAEAAKTSLSKALRVSFAGGSVMGMGVAGLAVLGLGALYLIIKQIFAPDAAVDSHEMERTIEILTGFSLGAESIALFARVGGGIYTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDVAGMGADLFGSYVATVLATMVLGRETFSQDAFGGYAPILLPMLIAGTGIIYSILGTLFVKISESTELDTAPVQNALNLGNWGSIIITAISSYFLVNYILPETMSLRGYEFTKMGVFGAIIVGLIVGTLMSIITEYYTAMGKRPVKSIVKQSSTGHATNIIGGLAVGMESTLLPILVLAGGIYGSYLCAGLYGVAIAAAGMMATTAMQLAIDAFGPIADNAGGIAEMSELPKEVRERTDILDAVGNTTAASGKGFAIASAALTALALFAAFVGIAGIDGIDIYRADVLAGLFVGGVIPFIFSSLAIKAVGEAAMAMVEEVRRQFREIPGILEGKATPEYEKCVAISTDASIRKMLLPGAIALISPLLVGFIFGPEVLGGFLAGATVTGVLMGMFQNNAGGAWDNAKKSFEKGVEINGETYYKGSEPHKASVTGDTVGDPFKDTSGPSMNILIKLMSIVSLVIAPTLAIMHKDQIDNNRREKIESLNKMMGVSAVAVPVTGMDAGVVTGPQEVRGTLNDEGDFVYDTGEIQEVKLSNKTIAIGQNSQLYAMYNGIKLEDQAVLDPNSWYTIENLYFQSGSSDLKPGAENALANLAEIMNDHPNVRIKLGGYTDDTGNADTNLKLSNLRAQTTKLKLLEMGIAADRIETEGYGPLFPVCEANDTDECKAQNRRIDVRVLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X606</accession>
    <name>C6X606_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806129.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01396"/>
    <dbReference type="EnsemblBacteria" id="ACU07844">
        <property type="protein sequence ID" value="ACU07844"/>
        <property type="gene ID" value="FIC_01396"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01396"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071512_0_0_10"/>
    <dbReference type="OMA" id="LHFAPEK"/>
    <dbReference type="OrthoDB" id="1730305at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="29159" checksum="A72377B653D9B153" modified="2009-09-22" version="1">MIKAIYQKTVPEKLRLQLHISLRKLKSVALSGDRFYCPCCTKSFSKFLSKGNGLELRPNAVCANCGSLERTRLLYLYLNNETSIFEGNPTILHFAPEDILKSKLVANPNYTDADINPNLARVQMDITDIKFENSYFDFIICSHVLGHIPDEKKALAELYRVLKPGGHLFFMSLINPDAAETFEDPQAVSPQQRLEAYGERDLQRLYGTDFGQRIRSSKVIVEQIDYRVHFSDDERRRMSLGDGKREIIYKVVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X614</accession>
    <name>C6X614_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative antibiotic resistance-related regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806137.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01404"/>
    <dbReference type="EnsemblBacteria" id="ACU07852">
        <property type="protein sequence ID" value="ACU07852"/>
        <property type="gene ID" value="FIC_01404"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01404"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_0_10"/>
    <dbReference type="OMA" id="EPKPHQN"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="156" mass="17790" checksum="7560E86886C6CB57" modified="2009-09-22" version="1">MKINTLTHAEETLMHTMWQLESAYLKDILAEYPEPKPHQNTVSTFLKILVDKKFLSVAKEGRVFRYNVSVPFGAYRQFLLKNLLQNYYGDSAANLVKSLADEKMIGTAEMNRLLGTDAPEKPIGEESANPVSEFIEEITAPKKAKKKDKKKKKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X620</accession>
    <name>C6X620_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor RpoD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01410"/>
    <dbReference type="EnsemblBacteria" id="ACU07858">
        <property type="protein sequence ID" value="ACU07858"/>
        <property type="gene ID" value="FIC_01410"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01410"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_10"/>
    <dbReference type="OMA" id="YQRWLAE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r1_2" evidence="5">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="141"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="294" mass="33756" checksum="31008E47267C2CA9" modified="2009-09-22" version="1">MDVFLYMRQLKITKQVTNRETASLDKYLQEIGKVDLITADEEVDLAQKIRAGDRVALEKLIKANLRFVVSVSKQYQNQGLSLPDLINEGNLGLMKAAKRYDETRGFKFISYAVWWIRQSILQALAEQSRIVRLPLNKIGSINKINKAYAHLEQENERPPSPEELAEVLDMSEDDIKESMKNSGRHLSMDAPLVEGEDSNLYDVLRSGESPSPDKELMLESLQIEIERALQTLTPREADLVRLYFGLNGKHPMTLEEIGETFDLTRERVRQIKEKAIKRLKHNTRSKILKSYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X644</accession>
    <name>C6X644_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_01434</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806167.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01434"/>
    <dbReference type="EnsemblBacteria" id="ACU07882">
        <property type="protein sequence ID" value="ACU07882"/>
        <property type="gene ID" value="FIC_01434"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01434"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_0_10"/>
    <dbReference type="OMA" id="PQDNGYK"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="43"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="204"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="318"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="485"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="572" mass="64097" checksum="2F87E755743DE491" modified="2009-09-22" version="1">MTTLEKAQLWLTETFDQDTRSIIEDWIKTNSDDLEDSFYRVLEFGTGGMRGIMGVGTNRLNKYTLGQATQGLANYLHTQFPGEQIKVAIAYDVRNNSREFGKMCADVLTANGISVLLFKEHRPTPELSFTVRDKKCHAGIVLTASHNPPEYNGYKVYWNDGAQIVPPNDDAIIREVYSVKFEDIKFTGNDALIEWIGDEQDEVYIDACMQNSLYQKDKIGYDNLNIVFTSIHGTTYTTVPQALKKAGFTKVDLVREQMIPSGNFPTVASPNPEEPAALEMALDLARITNGDIVIGTDPDGDRLGIAVRNLEGEMQLLNGNQCNTILTYYILDQWKKAGRITGKEFIGSTIVTSDIFIDIAEKFGVDCKIGLTGFKWIGKMIRDFEGTEKFICGGEESFGFMTGDFVRDKDSCGSILLACEIAAWCKANGKTMYQYMIEIYKETGMYYEGLINVVKKGRSGAEEITQMMTDFRLNPPAQIAGSKVTEVRDYKEQSSLNLTNNEKSVMDGIPKSNVLIYYTEDGTKVCVRPSGTEPKIKFYVSVKDSIDSEQDFQRKLTVLEAKIQQVKADLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X664</accession>
    <name>C6X664_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806187.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01454"/>
    <dbReference type="EnsemblBacteria" id="ACU07902">
        <property type="protein sequence ID" value="ACU07902"/>
        <property type="gene ID" value="FIC_01454"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01454"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_8_0_10"/>
    <dbReference type="OMA" id="KIFMDVY"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973739" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="20681" checksum="DF02BD81DE216EEA" modified="2009-09-22" version="1">MKQLTVLFLLFILMPAKAQVNWMTLEEAVKAQSEAPRKIMIDFYADWCGPCKTMDKETYGHPLISKYLNENYYPVKFNAESKESITIFGRTFSNPDFAAGKRKNSMHEFTKFMNVTAVPTIVFLDEQSMPITILQGALTAKELEPYIPFIAYDEYKKIETREQWENYQKKFKSNIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X692</accession>
    <name>C6X692_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07930">
        <property type="protein sequence ID" value="ACU07930"/>
        <property type="gene ID" value="FIC_01482"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01482"/>
    <dbReference type="HOGENOM" id="CLU_2649166_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="76" mass="8840" checksum="A700FF1B674B595A" modified="2009-09-22" version="1">MFYVAKRYFYSMKEIIFKLGALIVLVVSVLFLVGELALVLLVVAAELLFKNPTKTNRMGKRHFPKYHFPRLVGHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A9</accession>
    <name>C6X6A9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806232.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01500"/>
    <dbReference type="EnsemblBacteria" id="ACU07947">
        <property type="protein sequence ID" value="ACU07947"/>
        <property type="gene ID" value="FIC_01500"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01500"/>
    <dbReference type="eggNOG" id="ENOG502ZW1I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573360_0_0_10"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="476" mass="52818" checksum="506D8AA5D5671EF9" modified="2009-09-22" version="1">MKQKFTFLGMLFCVSISSQITLTKDSSFGNNGTATLTYPVEMEAVNFEKVFINADHSLNICLGTDGDSHTGMIAKLTSFGSLDTTYNGNGKIILNGNLHTGFEFAKQGEKMIAIYANDSNFNEPDTKIVRYRNDGSVDTAFGVNGVLAARPDLYYRQVNFQHDGFYHLWGKITGYRADGVLNSSYGSNGEQNPVINGVPQEYMELYSFFGNRGGRNFLNKYHHEIAVSKENTPHHFTSYDLTAHQFYDVAGATGGVSVYPKKFHLAPDKEIVYLFGIDPNSGNERNRVVLLDETMQPKMFSGQEFIDLGEVSAESEIRDVESFQNHYLFVGKTASKPVIIAYESNGKKSTVNGLDEFHDDSVADDYSTVLVNGNNIFVIGKRTGSREIFITKYTAKVLSTSETNPSKAYVTTPFKNELKVMSKVKTKNISVYDTSGRMIINSPKTTIATAHLPTGNYVVRVDFAEGPSQTFKSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B9</accession>
    <name>C6X6B9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01510"/>
    <dbReference type="EnsemblBacteria" id="ACU07957">
        <property type="protein sequence ID" value="ACU07957"/>
        <property type="gene ID" value="FIC_01510"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01510"/>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_1_0_10"/>
    <dbReference type="OMA" id="LWHHKHF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="19599" checksum="8BFD7343B85ACAFF" modified="2009-09-22" version="1">MMPIRIIKQSGIYTLTSEQIMPVSMDEAWSFFSLPTNLDKITPAEMKFFITNNPGVETYPGQIITYKIGIFPFIKNNWITEITHFREPSGTTLKKAFFVDEQRFGPYAMWHHEHHFEELSNGNLKMTDIVNFKLPFGIFGDILAGQFVKAKVQSIFEDRHRILTELFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D4</accession>
    <name>C6X6D4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806257.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01525"/>
    <dbReference type="EnsemblBacteria" id="ACU07972">
        <property type="protein sequence ID" value="ACU07972"/>
        <property type="gene ID" value="FIC_01525"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01525"/>
    <dbReference type="eggNOG" id="ENOG502ZAT4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975683_0_0_10"/>
    <dbReference type="OMA" id="QWHHLAF"/>
    <dbReference type="OrthoDB" id="1207414at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="2">
        <location>
            <begin position="106"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="280" mass="30855" checksum="201F25FE1D783562" modified="2009-09-22" version="1">MKNKILNMFGICTIALLALSCQDMDRPELGDFPKDASEPGGPLKFYVAFDGTSSNALMNAVDSVRAKFPSDNPLASIDGVSAKAVQGEKFKYIKYTSANDFAQTAGSFTVSVWTQKSQMKTDHIFSMPAVTDYHWSGGSMFLLTEGSVASPTIKFFVKDKTAEKWFEWVGANSPLGIYNGQWHHLAFVYDGTTSTMTLYVDGQPHAFKSEWTNHGNVVLEPSKITALKIGAGPQEFTEDQIANNGDDWLKNSYTGGIDQFRMYSTALTAAEVQALFTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H4</accession>
    <name>C6X6H4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ordered locus">FIC_01565</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806297.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01565"/>
    <dbReference type="EnsemblBacteria" id="ACU08012">
        <property type="protein sequence ID" value="ACU08012"/>
        <property type="gene ID" value="FIC_01565"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01565"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_10"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="106"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU08012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="336" mass="38635" checksum="76E49C9C0390A437" modified="2009-09-22" version="1">MLENIDNLLAEVGAFHSSDKAEIEQFRIRYSGKKGLLNDIFGQFKDVPNDQKKEFGQKINTLKQAVEAKLDSLKNATTSNLILEKEDLTRPGFPSELGTRHPISIVKNKIIDIFKSIGFAVADGPEIEDDWHNFTALNLPEYHPARDMQDTFFIETNPDILLRTHTSSVQIRYMEENQPPMRILSPGRVFRNEAISSRSHCIFHQIEGLYIDENVSFADLKQTIQFFTTELFGKSKIRLRPSYFPFTEPSAEVDVYWGLNSETDYRITKGTGWLEIMGCGMVDPAVLQNVNIDPDKYSGYAFGMGIERIVMLLYQMSDIRMFFENDKRMLEQFKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC5</accession>
    <name>C6WZC5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00501"/>
    <dbReference type="EnsemblBacteria" id="ACU06959">
        <property type="protein sequence ID" value="ACU06959"/>
        <property type="gene ID" value="FIC_00501"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00501"/>
    <dbReference type="eggNOG" id="ENOG5032RNV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1988684_0_0_10"/>
    <dbReference type="OMA" id="HESINIP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="136" mass="15884" checksum="85A949DFE3B8A8A2" modified="2009-09-22" version="1">MDAIQKFLYFYPMNDEFANESPKKDLGFILSLAGLMLFTVMGLGIDYDEYLQSDDLGIPGFYFIIIFGVDLLMIIGLILIFFYRKIGIYLFPTALMTHFLLHNYFLTTFLYTDVTNLFLFISVGLLAFIPKWQFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE2</accession>
    <name>C6WZE2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PorT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782120.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00515"/>
    <dbReference type="EnsemblBacteria" id="ACU06973">
        <property type="protein sequence ID" value="ACU06973"/>
        <property type="gene ID" value="FIC_00515"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00515"/>
    <dbReference type="eggNOG" id="ENOG502Z7U1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082712_1_0_10"/>
    <dbReference type="OMA" id="FKFTPSI"/>
    <dbReference type="OrthoDB" id="1506555at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970460" evidence="1">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="261" mass="30042" checksum="CFE6B0D455894FC6" modified="2009-09-22" version="1">MWKKIFITNLFAVFSLASFCDAQLFRTKDRQDNREEDDVRKYSYGFFLTANNFDYKLVLDPKFGMEGQKSLVQTKSSYSFGAGLIGKVRLNENFDLRFEPGLQFVEREIYFDTQTNDQYAAGTNSNAPFTPRTLTEEDKLRSVKSTYVDLPLLIEIHGDRWYNSRPYAAAGVNWMLNLQSNTDSPDDNAQGIFRSTSSNFAWSAEIGIQFYFSRFKLTPGFRGTFMVNDEMVPDNAETPPYWTPAIVSAKSRALMFVLKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG8</accession>
    <name>C6WZG8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smf protein DNA processing chain A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00025"/>
    <dbReference type="EnsemblBacteria" id="ACU06503">
        <property type="protein sequence ID" value="ACU06503"/>
        <property type="gene ID" value="FIC_00025"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00025"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_0_3_10"/>
    <dbReference type="OMA" id="CGVDIVY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="287"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="342" mass="37319" checksum="293ACAD1B9637217" modified="2009-09-22" version="1">MGEAGSAKEVWELSKSGLKNIYGIGKKISFEIGKAEHLLFAEKELSFCEKNNITINLRHLGHLPTHLNECEDAPAVLYQKGNLDSSLSAVSIVGTRNITTYGKSFISDFLADVKTHKILTVSGLALGADTEVHEVSINNNIPTAAVLAHGFHTMYPSKNRRLADKILEDGGVLLTEFNSSQKPDRENFIQRNRIIAGISPATIVVETAFGGGSVSTATFANNYNREVFALPGKITDKYSQGCNQLIFQNKAAAISTVSGLAEQLGLHKTEQTGVLFPSSEIRIKLPEQQLILLEALDKNTPLSLDDVSLKLDVPAYRILPDLLELELLGYIRALSGRQYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI2</accession>
    <name>C6WZI2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB family biopolymer transport prote in</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781664.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00039"/>
    <dbReference type="EnsemblBacteria" id="ACU06517">
        <property type="protein sequence ID" value="ACU06517"/>
        <property type="gene ID" value="FIC_00039"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00039"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_4_0_10"/>
    <dbReference type="OMA" id="AYIGYNH"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="91"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="226" mass="24812" checksum="1FF8F28260896ACB" modified="2009-09-22" version="1">MFLQAPTQVISTTTETHVFSLWNILFSGGILGNSIMIAIFLLGILALYIFFERYLFIKRSSKETPNFLENIKDFVQEGKIQTAVDYCKTIDSPEARMIEKGLARIGRPISDISNAMQNQGQLEVSKLEKNLNILASASGAAPMLGFLGTVVGMIMAFFEISNVTGAVSPKLLASGIYTAMATTAVGLFVGIPAYFFYNILVTNVDRLVLKIQTHVNDFLDALNKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI9</accession>
    <name>C6WZI9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06524">
        <property type="protein sequence ID" value="ACU06524"/>
        <property type="gene ID" value="FIC_00048"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00048"/>
    <dbReference type="HOGENOM" id="CLU_2716506_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="72" mass="7712" checksum="0DE048416126BC4C" modified="2009-09-22" version="1">MFSVVPLVFATASGAVRVEALVSAGGIILADDVFVLLSLFFFASQDKSIVAAPNNNKGNFFIVINFRLKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ9</accession>
    <name>C6WZJ9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="7" type="ordered locus">FIC_00058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781681.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00058"/>
    <dbReference type="EnsemblBacteria" id="ACU06534">
        <property type="protein sequence ID" value="ACU06534"/>
        <property type="gene ID" value="FIC_00058"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00058"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_10"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="361" mass="40497" checksum="2407D214188AA686" modified="2009-09-22" version="1">MSKSLIPKLEAIKQRYNEVADLIIQPDIISDQKKYSALNKEYSDLGKIVSVFDQYTQAINSIAESDEIIADGSDKEFVEMAKMEKNEALEKIPQIEEELKVLLIPKDPADDKNVIVELRAGTGGDEAAIFVEDVYRAYAMFFKTKGWKHEITDANEASKGYKELILKVEGEGVYGIMKFESGVHRVQRVPETESQGRVHTSAITVAVLPEAEEVDFELNPADIEMQTSRSGGAGGQNVNKVETKVQLTHKPSGMVVVCQQARSQLANRELAMEMLRTKLYDIELQRVQGDIAAQRKTMVSTGDRSAKIKTYNYPQGRVTDHRVNKSVYNLDAYMNGDIQEMIDAVIMAENAEKMKGEEENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM5</accession>
    <name>C6WZM5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781707.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00084"/>
    <dbReference type="EnsemblBacteria" id="ACU06560">
        <property type="protein sequence ID" value="ACU06560"/>
        <property type="gene ID" value="FIC_00084"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00084"/>
    <dbReference type="eggNOG" id="ENOG5033SD2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1657726_0_0_10"/>
    <dbReference type="OMA" id="CENAVYA"/>
    <dbReference type="OrthoDB" id="1487631at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973412" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="160" mass="18330" checksum="8B579961ACA9543D" modified="2009-09-22" version="1">MKKLLFLLAFAGSFMNAQYLVEETDISDNSSELAKLSIYYDLNNPMEFYRLKCENAVYAQFPGGENAFKQTLFTSLQSYLDTSLYSVNGTFELILFISKTGNLQSFQLKPEVQNSNLLYRDLELTLRRMNPKWTPASCGGEPTESKLRQKLNFRTEASDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ8</accession>
    <name>C6WZQ8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00118"/>
    <dbReference type="EnsemblBacteria" id="ACU06593">
        <property type="protein sequence ID" value="ACU06593"/>
        <property type="gene ID" value="FIC_00118"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00118"/>
    <dbReference type="eggNOG" id="ENOG5032UD6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122390_1_0_10"/>
    <dbReference type="OMA" id="FRITIYS"/>
    <dbReference type="OrthoDB" id="1950812at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025347">
        <property type="entry name" value="DUF4251"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14059">
        <property type="entry name" value="DUF4251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972150" evidence="1">
        <location>
            <begin position="36"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="21053" checksum="56049888767F6732" modified="2009-09-22" version="1">MHNFCIHAVKLLMKKLFLYLSALLLTVMVSCGTTSGLPKAQVNALLSSGEFTFMAERANPTNYDVVNVMNSFPNSSSSRMLTLDYGYTVQIRKSEVKVELPYFGRSFTPSYDTTKSSYRFTSKDFNISQRDGKKGSVVYTILPNDQPNVQKITVEVYPQGKAYVAVSSNDRQGISYDGYIMANEQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZS5</accession>
    <name>C6WZS5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781757.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00135"/>
    <dbReference type="EnsemblBacteria" id="ACU06610">
        <property type="protein sequence ID" value="ACU06610"/>
        <property type="gene ID" value="FIC_00135"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00135"/>
    <dbReference type="eggNOG" id="ENOG502ZBQZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105419_0_0_10"/>
    <dbReference type="OMA" id="WIYQANR"/>
    <dbReference type="OrthoDB" id="1436985at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="163" mass="18548" checksum="CA0ECC0CFC915F44" modified="2009-09-22" version="1">MKIEESNKVETNDYRVIIYPASRPFTAKESMVITKKLYDFLAGWAAHGKPLSSSFKIERNQFIVVCVDEEKEAASGCSIDALGGVMREIDQEYQLGLFDRMKATFVENGETKTMKLQDFRNALKSGEISTDIEVFDFSKNTYLAFLSDFLLPLKRSWAGIYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZS6</accession>
    <name>C6WZS6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00136"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06611">
        <property type="protein sequence ID" value="ACU06611"/>
        <property type="gene ID" value="FIC_00136"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00136"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723101_0_0_10"/>
    <dbReference type="OMA" id="YHFHDPE"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="382" mass="44134" checksum="C92D726F86BC9B6A" modified="2009-09-22" version="1">MMCDMPKILFLTTAHRYDDDRIFHHQAKELFRQGFKGKICSLSSDYQGELDGISIEAYDILAQSSGAKSETFRKILQDFSPDAIIASEPLAVIAAKDFTRQNKCPLIYDITEWYPSTRMLKPYRFPANIFHLLRFVIIQIYGGFLATHFIFGEKTKRFPLAQLFPFKPNILLPYFPDERYIFPAVNKLRHNAITLCYTGSFTKEKGIENFFNAAEVLRSARPEVEISLLLIGSTPKSESSDYFSQLLAQYSFENITIKEPSNFEDFTKSFSEADICFDLRPDNYENNRCLPIKLFYYAAAGKPVIYTDLNAIREHVDISKFGHLVNPTDSSHIANLISEYIDDPKRYNQHAGNALNSYRKHYNWSNINDLFVNFIKKALCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV7</accession>
    <name>C6WZV7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781789.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00167"/>
    <dbReference type="EnsemblBacteria" id="ACU06642">
        <property type="protein sequence ID" value="ACU06642"/>
        <property type="gene ID" value="FIC_00167"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00167"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_10"/>
    <dbReference type="OMA" id="AMEMIMT"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="255" mass="27524" checksum="4C29507931B77B46" modified="2009-09-22" version="1">MIYDNIIVETEERIAIITINRPESLNALNSKTIAELSDSFENLNKNPEIRVIILTGSGEKSFVAGADIKEFSDFGAADAENLSRNGQQILFDKIENLSKPVIAAVNGFALGGGLELAMACHIRYASENAKLGLPEVTLGLIPGYGGTQRLPKLVGKGLANEIIFSAKMIPAARAKEIGLVNDVVSSDELLSQSKDLARTIARNSPMAIEKAISAVNLSDSTSGFETEMKSFGELFEMNDKKEGVSAFLEKRKPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X010</accession>
    <name>C6X010_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M23B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781842.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00221"/>
    <dbReference type="EnsemblBacteria" id="ACU06695">
        <property type="protein sequence ID" value="ACU06695"/>
        <property type="gene ID" value="FIC_00221"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00221"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_4_2_10"/>
    <dbReference type="OMA" id="VVHFEIW"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="431"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="527" mass="58337" checksum="A2D73F931705A0B3" modified="2009-09-22" version="1">MIRKISFFIGLFLFGILFSQKKEQLQKQNAELKKQIASINANLAKTQQQSKLSVAYLNDVQKKIQLREKVYTNTQKEKRLIEDDIYLRQLEINRQNRELAVLRKNYAEVLVKAYKNKGVQNKVTFILSSKNLGEALRRIQYLKDYSDYQDKKAAEISEAARKLVANINAKQKSVKDKETILSNQQKDLQTIAVEKKQKENLLQDFKKNEAQLTAELKQKQTESKQLEGQIRSIIAEEIRIAKAQEEARKKAEAEKIRLAKIAAEREKARIEAENKARMEALALEKKRADEEAKRLKEISDKKAAEEESRSRIAAAADAKKTEDANKAADAEKAEARRAAAAKDAAVAAANARAAADKAADARAAEASLAKKNEDQKKAAETKAMTNYGVSSAVGNNFSANRGKMGMPAYGTITHRFGRQPHPVFKNIIEENNGIKIAVSKGTVAKCVAPGTVSRVVASGDGSKMVFVKHGDYFTIYANLSGAMVSANQQVSAGTSIGAVGADFDGTYTLDFQIWHGTSPVDPLGWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X012</accession>
    <name>C6X012_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.24" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781844.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00223"/>
    <dbReference type="EnsemblBacteria" id="ACU06697">
        <property type="protein sequence ID" value="ACU06697"/>
        <property type="gene ID" value="FIC_00223"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00223"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_10"/>
    <dbReference type="OMA" id="EWMDCGN"/>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="339" mass="36808" checksum="B40D9E894E38A361" modified="2009-09-22" version="1">MKIIVPMAGRGSRLRPHTLTVPKPLIPIAGKPIVQRLVEDIAKVAGEKIDEIAFIIGDFGSEVEASLIQIAESLGAKGTVYTQDEPLGTAHAIKCAENSMQGDVVVAFADTLFKADFILDKNSDGVIWVKKVDDPSAFGVVKLDDYGFITDFVEKPATFVSDLAIIGIYYFNSAEKLMDEINYIMSNDIKQGGEYQLTTALENLRQKGAKFSLGKVDDWMDCGNKNATVETNGKVLNYEKDNVANFPASAKIENCLIIPPCFIGENVQISNSKIGPCVSVGNNTIVINSNIDHSLIQENTLIDHGNLSNSMIGNSAQYFGVAREISLGDYSVLDFLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X047</accession>
    <name>C6X047_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ordered locus">FIC_00259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00259"/>
    <dbReference type="EnsemblBacteria" id="ACU06732">
        <property type="protein sequence ID" value="ACU06732"/>
        <property type="gene ID" value="FIC_00259"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00259"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_1_0_10"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="113" mass="12236" checksum="A70E465A3108D471" modified="2009-09-22" version="1">MQWQSFGERMGKRKLTKNKNIMSVNFKPLADRVLVEPNAAETTTASGIIIPDTAKEKPQEGTVIAVGPGKKDEPTTVAVGDKVLYGKYSGSELKLDGKDYLIVKESDILGIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X065</accession>
    <name>C6X065_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781897.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00282"/>
    <dbReference type="EnsemblBacteria" id="ACU06750">
        <property type="protein sequence ID" value="ACU06750"/>
        <property type="gene ID" value="FIC_00282"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00282"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153689_0_0_10"/>
    <dbReference type="OMA" id="EFVVDFI"/>
    <dbReference type="OrthoDB" id="1968538at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021857">
        <property type="entry name" value="DUF3467"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11950">
        <property type="entry name" value="DUF3467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="105" mass="11815" checksum="40C37B13DB61B89B" modified="2009-09-22" version="1">MDNNQNQNQNQDPNNININLNEMIAAGVYCNLALVNHSPSEFVVDFIQLMPGVQQANVRSRVILAPLHAKRVLTALQQNITNYEQQFGEIKEIEPFVLGQNNVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X085</accession>
    <name>C6X085_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781917.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00303"/>
    <dbReference type="EnsemblBacteria" id="ACU06770">
        <property type="protein sequence ID" value="ACU06770"/>
        <property type="gene ID" value="FIC_00303"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00303"/>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_6_0_10"/>
    <dbReference type="OMA" id="QMLFIGD"/>
    <dbReference type="OrthoDB" id="961809at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029491">
        <property type="entry name" value="Helicase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14493">
        <property type="entry name" value="HTH_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Herpes_Helicase" evidence="4">
        <location>
            <begin position="354"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_40" evidence="5">
        <location>
            <begin position="611"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="709" mass="82399" checksum="1E4C1ACAF3D546AD" modified="2009-09-22" version="1">MNESLFNLAEHTHRSIFLTGKAGTGKTTFLNDFVRKTHKKYIVVAPTGIAAINAGGVTIHSMFGLPLRTFLPTTERINSESANNIADLMHHFRYRKDKQKLLREIEIIIIDEVSMLRADVLDMMDFALRHVRRNQQKFGGVQMLFIGDLYQLPPVVRDEHVLKQYYASPFFFDSYALKELPLITLELTTVYRQKDEKFLEILNEIRDGEIRDIDFDTLNERYIPDFEPKDEPYVYLTSHNRMADEINQKKLAALPGKAHFYKAEIIGNFNENQYPNDEILELKVGAQIMFLRNDASGEKRYFNGKLAEIVKLDEKEISVIIDGEEEVYKLKKETWEQKKYSLGEDKSVQEEVLGSFNQYPIRLAWAVTIHKSQGLTFDRLIIDAGKSFASGQVYVALSRCRTLEGIVLKSKITPEVIYSDKRVSKFQDDTHANEKIDEILNAEKYDYSIQKIVSRLDCQWILPAMEAWYKTAKVSSVIDKDKVRFLYQAIKPEIENFNAVFVKFDKIVHQKTQKFVAGTETWEEIESKAKGAVNFFFKNVNAKVFRPLKDFYAESKGVKGLKQYNEDFRVFLDDLEDYLNDLKSVHLLETALFDRQNEEVVTAKVAKIPSHILTFQLFEEGKTIPEIARDRGLVTETIFGHLAKFAERGLLDLTRIFDKEKIKTFEKEFKKNSSRETLSEWKQVLPNDFEFNEIRLLLNHFNYKAAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C4</accession>
    <name>C6X0C4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative poly-gamma-glutamate synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781956.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00342"/>
    <dbReference type="EnsemblBacteria" id="ACU06809">
        <property type="protein sequence ID" value="ACU06809"/>
        <property type="gene ID" value="FIC_00342"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00342"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038823_2_1_10"/>
    <dbReference type="OMA" id="GRCDHIA"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="378" mass="42802" checksum="4689256D92117D1A" modified="2009-09-22" version="1">MNNSIILCGDLCPTDDTEAFFKAEDQHALFSDCLPLFKSAGLTAGNLEFVLTDDPQPIMKSGPILYGPTTHINVLKKAGIDIFSLANNHIKDCGEAGVKSTIATSADAHIETFGAAHNLQAAKKPFIGEVGGKKIGFLAFAEQEFNTAGADEYGSSFFDPFEDLDLIEKTRKSVDYLIVIYHGGIEYYEYPSPMLQKKCRRFVDKGADLVTCQHSHCIGTIENYNSKDIVYGQGNTLFGYRDGNDSWNEGIIIQLNLDGKDLKIDYLGVKARKEGGIRLMNDRENETLTEKLEKRSRQIKDAGFIQQSWQAFCKRKESLYLPQYLALNRYFIHLNRWTRNRFISLFYGRKYLRSSHNIMRCEAHNEVIQTLLQLKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E8</accession>
    <name>C6X0E8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular polysaccharide biosynthsis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781981.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00367"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06834">
        <property type="protein sequence ID" value="ACU06834"/>
        <property type="gene ID" value="FIC_00367"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00367"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_10"/>
    <dbReference type="OMA" id="AKESISH"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="388" mass="44674" checksum="FDC4CA8880469CC0" modified="2009-09-22" version="1">MWKILILNNDLELGGIQKSLIEFVTYLVHSNEFSVDLMLWQKNGPLQKMLPAEVNIIFKNYPATANDILTAKKPLQKLTLLYPFFKSLYCNRILGKPWIFYPKVPTHYDIAVSFTHNGFPRFFSIDRVSANQKFLWFHHGSYHGSVREKDLDNQYYRQFDRIVTVSEANKSMLSSVFPDLRQRLAVVPNIINFGEIILKANETISDMPQNPNEYRFVTVSRFSPEKGLDLALEIASLLNQKGLTFRWYFVGDGPQYSEIQQLAQDKGVAEECVFVGSKENPYAYIKNADLYIQSSYVEAHPITINEALTLKKMIVSTDIASIREILNNGKLGMLCKPEAEIFADAIFELLKNELKQRNLKNAVEEYNFTNEAAYEAINNVLNIRIQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F0</accession>
    <name>C6X0F0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781983.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00369"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06836">
        <property type="protein sequence ID" value="ACU06836"/>
        <property type="gene ID" value="FIC_00369"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00369"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_10"/>
    <dbReference type="OMA" id="IMPLWEE"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="362" mass="40017" checksum="AB6FE543CBA5B355" modified="2009-09-22" version="1">MKLLYITNGITGAGGLERVLSVKTSMLAEDFGYTVHILSLNEGGVKPFFTFSDKVVLHSAELPGNPVYYFFKYKTGIQKTVSKVQPEIICVCDDGLKGFFLPYMIRTEAKWIYESHASVNLGDRGRGVSVGVKFQHSLKQVLGKAFSKIVLLTESNKKEWALDNLVIIPNPLPFQISGVSSLQSKKVIAVGSFGYNKGYDLLLKIWQNVETGFPDWELDVYGKGTYENLLPDADKLGLQRINFHQPAADIATKYLESSIFVLPSRSEGFGMVIIEATSCGLPVVSFNCPHGPGDIITDGKDGFLIENGNNIQFAQKLQLLMANADLRLELGSAGKKSSEKYLPQKIVRQWDDLFSSLVQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F4</accession>
    <name>C6X0F4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00373"/>
    <dbReference type="EnsemblBacteria" id="ACU06840">
        <property type="protein sequence ID" value="ACU06840"/>
        <property type="gene ID" value="FIC_00373"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00373"/>
    <dbReference type="eggNOG" id="ENOG502Z8DC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749356_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="364" mass="42488" checksum="D7A37D324ABDA546" modified="2009-09-22" version="1">MFDWIPLNSYTPIYHHMMLFIMLITLLHAYQNDLFDMRTRYFSTGMGIALLIFIVLYLGTRPVSYVFGDMGTYGKFYNMVASGQEPIIKNDYFFNYFLLACSKVMSDRTFFFVCAILYVLPCYLFSRKYCGSYWYFVLFIFTASLMFWPFGTNGIRNGLATSLFIWALCFYNTKYLMYALMALAFGIHNSMIIPIAGFAVAGVYKNPKLYYYIWLAAIPLSLIGGGFWEGLFGGIGLGGDTRAEDYLTKGNVNNDEFAYTGFRWDFLFYSSFAAFAGWYFIFKKKITDTFYIHLWGTYMIANAFWILVIRANFSNRFAYLSWFLMAPVIAYPLLRYKIFPNQYRVIGAVIAVYYLFTYVMFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0H8</accession>
    <name>C6X0H8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="7" type="ordered locus">FIC_00397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782011.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00397"/>
    <dbReference type="EnsemblBacteria" id="ACU06864">
        <property type="protein sequence ID" value="ACU06864"/>
        <property type="gene ID" value="FIC_00397"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00397"/>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_2_10"/>
    <dbReference type="OMA" id="VACVIDA"/>
    <dbReference type="OrthoDB" id="1632367at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="36"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="25264" checksum="9E46D0E21112557A" modified="2009-09-22" version="1">MNQEIDNDDDVFTGKDHTPLRDDAFAKSTDEKIEIIQHHFHQIMETLGMDMTDDSLKDSPKRVARMYVNEIFGGLLPENMPRISTFSNKYKYRQMLVEKDITVYSFCEHHFLPIIGRAHVAYISNGEVIGLSKINRIVDYYARRPQVQERLTMQIVDALKSALGTKDVACIIDAKHLCVNCRGIRDTASSTITAELSGIFRTNPITRQEFLHYVGSHAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J1</accession>
    <name>C6X0J1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782024.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00410"/>
    <dbReference type="EnsemblBacteria" id="ACU06877">
        <property type="protein sequence ID" value="ACU06877"/>
        <property type="gene ID" value="FIC_00410"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00410"/>
    <dbReference type="eggNOG" id="ENOG502ZD9S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115785_0_0_10"/>
    <dbReference type="OMA" id="HVKITKD"/>
    <dbReference type="OrthoDB" id="1478929at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="203" mass="23881" checksum="1A037B0E6B89C6FC" modified="2009-09-22" version="1">MEYSKEFKKALSEFSGTEKDKLIFRLLKKDKILSKKLYFELIDPENEDDKRAQMEVLISDEVAAAAKHLRNPKYFLVLIRKISAKITEHVKITTDKLGDVSLNLMLVTEILSKTDHFRDGYKLYMYLLNKIFKILIQTQKLDEDYFLEIQDGFEKLYDLILKNHEFEKLALLHGLDLNWLSPSEIPEHIALIQKEIKSQGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L8</accession>
    <name>C6X0L8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782051.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00442"/>
    <dbReference type="EnsemblBacteria" id="ACU06904">
        <property type="protein sequence ID" value="ACU06904"/>
        <property type="gene ID" value="FIC_00442"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00442"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_10"/>
    <dbReference type="OMA" id="YWTAAQQ"/>
    <dbReference type="OrthoDB" id="819833at2"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="16"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="124"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="415" mass="46725" checksum="4786C0CF4D7434AA" modified="2009-09-22" version="1">MKSFVNYAQDSDFSIHNIPFGVAVFDQEYIACCTRIGDLVIDLATLYDYGYFDEISGINENVFEAYTLNEFIELGKPVTNAVRLKLQELLSEDSKLANDEKTKEDCFFDLDKVKMMMPVHIPNYTDFYSSIEHATNVGKMFRDPANALLPNWKHLPVGYHGRASSIVVSGTDIIRPKGQTKPADADSPVFGPCKQLDFELEMAFIVNKHTEMGDSITTAEAEDAIFGMVLFNDWSARDIQSWEYVPLGPFLGKNFGSSISSWVVTLEALEPFRTASPIQQPEVLDYLKFEGEQNFDINLQVYLQPEKGTECLVSESNYKFMYWNMTQQLAHHTVNGCNIEVGDMYASGTISGTDPKSFGSMLELTWRGQNPLKLNDGQERRFIEDHDTVIMRGFAEKDGIRVGFGEVSGTILPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M7</accession>
    <name>C6X0M7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase</fullName>
            <shortName evidence="6">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pnp</name>
        <name evidence="9" type="ordered locus">FIC_00451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00451"/>
    <dbReference type="EnsemblBacteria" id="ACU06913">
        <property type="protein sequence ID" value="ACU06913"/>
        <property type="gene ID" value="FIC_00451"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00451"/>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_10"/>
    <dbReference type="OMA" id="LHILDVM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="631"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="695"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="780" mass="86917" checksum="79AA384346B79EBD" modified="2009-09-22" version="1">MNVPQAIIETIQLKDGREITIETGKLAKQANGSVVVRMGGTMLLATVVANKDASPGVDFLPLTVDYREKFYSGGKIPGNFFRREARPSDEEILTMRLVDRVLRPLFPDDFHAEVQVMISLISYDKECMPEALAGLAASAAIAITDIPFNGPMSEVTVARIDGQLVVNPSRENLDKADLNILVGATKDSIVMVEGVMDEITEEEMIEAIKFAHEEIKVQVEAQERLAERVGKSLPKREYTHENHDEEIREKVWKDTFDKVYEVAKTPSAKEERHDNFKAVLEEFLAQYSEEELETVKPFAKIYFHDVEKEAMRQMILNEKIRLDGRTPETIRPIWSEVDYLPGAHGSAVFTRGETQSLTAVTLGSVKDANMVDSVAINYDEKFFLHYNFPPFSTGEARPLRGTSRREVGHGNLAQRALSRIIPAENPYTIRIVSDILESNGSSSMATVCAGTLALMDAGVQITKPVSGIAMGLVTDPESGKFTVLSDILGDEDHLGDMDFKVTGTADGITACQMDIKIQGLSMDIMETALKQAREGRLHILGEMLKTLDAPRVDVKPHAPKMEVLEIPKEFIGGVIGPGGKIIQQMQKDFQTVIAIEEIGEIGRIEISGVSRENINATIAAINEITFVPTVGEVYNGRVVKVMDFGAFVAIAKGTEGLLHISEIEWARLDKVPYNEGDMVEVKFMGYDDRKKMKLSRKVLLERPPRTERKEGEGENRENRDSRPPRNDRRDGGDRRRDDNFNRGNNRPEHSGRQTEKPAGEDTFKPLNESENTDDVKPEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P9</accession>
    <name>C6X0P9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapA</name>
        <name evidence="10" type="ordered locus">FIC_00473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782082.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00473"/>
    <dbReference type="EnsemblBacteria" id="ACU06935">
        <property type="protein sequence ID" value="ACU06935"/>
        <property type="gene ID" value="FIC_00473"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00473"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_10"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="290" mass="31822" checksum="CFE7A9D55C8F2ADC" modified="2009-09-22" version="1">MSILKGVGVALVTPFNEDLSVDFDSLTKLVDFNIENGTSYLVVLGTTAEAATLSDQEKSEVINHIIKANNKRVPLVLGIGGNNTMEVKKQIEETDLSAFEAVLSVSPYYNRPNQEGLYQHYKMLAGTGKKIIIYNVPSRTGQNIEASTTLRLAEEFPNLIMIKEAAPNILQYFDILRLKPAHFNLVSGDDEFTLPVTLAGGNGVISVIGQGYPKEFSEMVQLALDRKVDQAYKIHNSLVEITRLIFAEGNPAGIKTVLAEKGIIQNYLRLPLVEASEGLKQKIKAAMAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0T1</accession>
    <name>C6X0T1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-oxoadipyl-CoA thiolase</fullName>
            <ecNumber evidence="4">2.3.1.174</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:19481"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57348"/>
            <dbReference type="EC" id="2.3.1.174"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806329.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01598"/>
    <dbReference type="EnsemblBacteria" id="ACU08044">
        <property type="protein sequence ID" value="ACU08044"/>
        <property type="gene ID" value="FIC_01598"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01598"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_2_2_10"/>
    <dbReference type="OMA" id="EPMRPGT"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012793">
        <property type="entry name" value="PcaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02430">
        <property type="entry name" value="pcaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="9">
        <location>
            <begin position="277"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="404" mass="42869" checksum="9A7C2EA73D28E4A7" modified="2009-09-22" version="1">MKNAYIIDGTRSPIGNFKGSLAAVRTDDLLASVIKSLVNKNPEIPLHRIDDVIIGCANQAGEDNRNVARMASLLAGLPVNVPGETVNRLCASGMSAVVQAARAIKSGEGDLFIAGGVEGMSRAPFVISKAENTFATDQKMYDSSFGWRFINPEMEKMYGVDAMGKTAENLAEKFDISREDQDLFALNSQKKAYKAQQNGRLAEEISEIVIPQRKGDPKIINEDEFLKPDSSLEVLAKLRPAFVKETGSVTAGNASGLNDGAAAVLIASEDAVNEFNLKPLARIVTSAVTGAEPRIMGIGPVEATRLALKRAGLTLDQIDVIELNEAFAAQSIACLMELGVANDDPRVNVNGGAIALGHPLGMSGARITYSAALELSRTGKRYALATMCVGVGQGYAVILENDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0T7</accession>
    <name>C6X0T7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose 5-phosphate isomerase</fullName>
            <ecNumber evidence="8">5.3.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806335.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01604"/>
    <dbReference type="EnsemblBacteria" id="ACU08050">
        <property type="protein sequence ID" value="ACU08050"/>
        <property type="gene ID" value="FIC_01604"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01604"/>
    <dbReference type="eggNOG" id="COG0794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_13_1_10"/>
    <dbReference type="OMA" id="LMACLMR"/>
    <dbReference type="OrthoDB" id="571638at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019146">
        <property type="term" value="F:arabinose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="35"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="268"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="319" mass="34160" checksum="E7170B356ACF63A8" modified="2009-09-22" version="1">MNNEEILRTARTAIETEISELENLKNRLDASFLKAVEIINSSKGKLIVVGIGKSAHVGNKIVATLNSTGTPSQFLHASEALHGDLGVIQKSDVVLCISNSGNSPEIVNLLTYLKGYSSALIGMTGNLNSKLAEISDVVLNTSVEKEACPIKLAPTSSTTVQMALGDVLAVCLMEINGFKESDFAKFHPGGALGKNLTAKVEQFLSPQKPQVSENAGIREIIISISASTHGITVVTDDERITGVITDGDLRRMLISQQNLTKVTAVDIMTKNPKSVDKNALAKEAMQILKDKNIGQLIVTDNGKYSGIIDIHRLLDEGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0V8</accession>
    <name>C6X0V8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01626"/>
    <dbReference type="EnsemblBacteria" id="ACU08071">
        <property type="protein sequence ID" value="ACU08071"/>
        <property type="gene ID" value="FIC_01626"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01626"/>
    <dbReference type="HOGENOM" id="CLU_2934726_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="60" mass="6801" checksum="83DD9E7B8240F62E" modified="2009-09-22" version="1">MRNLMHQKMEIYPVGICLLAALVAEPLVHQQELPAVQAPAFGMFHGLSFIKFKYLEAVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Z1</accession>
    <name>C6X0Z1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ordered locus">FIC_01660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806389.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01660"/>
    <dbReference type="EnsemblBacteria" id="ACU08104">
        <property type="protein sequence ID" value="ACU08104"/>
        <property type="gene ID" value="FIC_01660"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01660"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_0_2_10"/>
    <dbReference type="OMA" id="RFPVKYY"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="123" mass="14094" checksum="602A328130B92D9C" modified="2009-09-22" version="1">MNIPENYIPILITFAVGFGFVMLCVLGTHFLGPKQKESSFKKNESFECGIDVEGNARSPFSVKYFLTAVLFVLFDIEIVFFYPYAVNLREFGVEGFFAVLTFISVFLLAFVYVWKRGALDWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X102</accession>
    <name>C6X102_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase chain L</fullName>
            <ecNumber evidence="10">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806400.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01671"/>
    <dbReference type="EnsemblBacteria" id="ACU08115">
        <property type="protein sequence ID" value="ACU08115"/>
        <property type="gene ID" value="FIC_01671"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01671"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_0_10"/>
    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="9">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="135"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="631" mass="69850" checksum="6A1A33E2233CE1E0" modified="2009-09-22" version="1">MENLIYAIVLLPLLGFLVNGLFGKNLPKMVVGSIATLVVFASFCIAVSIFLKFDADSQPVIVRAFEWFRISGIQVNFSFQIDQLSLMMVMIITGIGSLIHLYSIGYMSHDKGFYKFFAYLNLFIFSMLLLVMGSNYLILFIGWEGVGLCSYLLIGFWYTNAEYGAAARKAFIMNRIGDLGMIIGILMIAYQTNAVDFLSVAQNSSKFELDSPVIIFITISLFIGAVGKSAQIPLFTWLPDAMAGPTPVSALIHAATMVTAGIYLVVRSNFLFSLAPSTLEGILYVGLLTALVAAFIGLRQNDIKKVLAYSTVSQLGFMFVALGVGAYTTAMFHLMTHAFFKALLFLGSGSVIHAMSGEQDMRLMGGLKKKIPITHITFLIGTLAISGFPFLSGMISKDEILANVYGKSPFLWVALFIVATLTAIYMFRAYYLTFHGEFRGTEEQKHHLHESPKSMTVPLIVLAVLSIVGGFINLPHFIGHGNYAKLGEWLKSVYVYDLELPEVNFGTEMILLGLTVLMFFTVWFFVKKTYVDKKKMALPEDKYTGWERLSNKKLFLDELNSAMIVRFIEGLGVAGNMFDKGVLGRFTDFIGTGAEDSGRAAKRLQNGNVENYVLIMSLAIGIILIVNFILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X112</accession>
    <name>C6X112_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806410.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01681"/>
    <dbReference type="EnsemblBacteria" id="ACU08125">
        <property type="protein sequence ID" value="ACU08125"/>
        <property type="gene ID" value="FIC_01681"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01681"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065741_0_0_10"/>
    <dbReference type="OMA" id="QCHFGQD"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="53"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="264" mass="30290" checksum="4CB6FF751050BADB" modified="2009-09-22" version="1">MENYLDINRNSWNAKVEPHLKSDFYFVDEFIAGRTSLNSIELELLGDIKVKKILHLQCHFGQDSISLSRMGAYVTGVDLSDKGIAAAKDLAAQCGTDTRFVVADLYQLPELLNDKFDIVFTSYGTIGWLPDLHKWANVISHFLKSGGKFVFVEFHPVIWMFDDDFTHIKYNYFNEKAIVETNEGTYADKTAPLVLDFVMWNHPTSEVLMSLLNASLEILSFEEYNWSPYACFNQNDEFEKGKFRIPQFGNKVPHVFSLVAEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X126</accession>
    <name>C6X126_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase SixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806424.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01696"/>
    <dbReference type="EnsemblBacteria" id="ACU08139">
        <property type="protein sequence ID" value="ACU08139"/>
        <property type="gene ID" value="FIC_01696"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01696"/>
    <dbReference type="eggNOG" id="COG2062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084603_2_2_10"/>
    <dbReference type="OMA" id="DRPLNKR"/>
    <dbReference type="OrthoDB" id="1707924at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="162" mass="18251" checksum="57F62038C68D4C24" modified="2009-09-22" version="1">MKTIILVRHAKSDWPEDTEDFDRPLADRGIHDAGRMAEHLKKSGIVIDKLVTSPALRALNTCKIFNQRYLTDMETNRKLYNANESNFESVIYGLTDDINSVAIFSHNNGISNFANMLCDDIFVFPTCGVAGFQISCDSWADFEGATKELAFYYEPKSIEANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X135</accession>
    <name>C6X135_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01705"/>
    <dbReference type="EnsemblBacteria" id="ACU08148">
        <property type="protein sequence ID" value="ACU08148"/>
        <property type="gene ID" value="FIC_01705"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01705"/>
    <dbReference type="eggNOG" id="COG3212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111475_0_0_10"/>
    <dbReference type="OMA" id="FPNDQIV"/>
    <dbReference type="OrthoDB" id="1791395at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021533">
        <property type="entry name" value="PepSY-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11396">
        <property type="entry name" value="PepSY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY_like" evidence="1">
        <location>
            <begin position="77"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="161" mass="18317" checksum="6D9944EE00B4F0FB" modified="2009-09-22" version="1">MQNLPYYFIKRNIRKMNTLKTNPIVAGFTCLFLFAGCEDHKIIPQTELPPEVTAYILNNFKHTTIAQATQEREGLGKTYDIVLADGIILEFNGKNEITEIKGNRAIPDGVVPQKIRTYVNQKYPGSTIKQWQNEGNGQQVKLDNGIELKFNKAGDFQRIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X157</accession>
    <name>C6X157_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01727"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08170">
        <property type="protein sequence ID" value="ACU08170"/>
        <property type="gene ID" value="FIC_01727"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01727"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032719_1_0_10"/>
    <dbReference type="OMA" id="LRFTTNH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="46"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="457" mass="53126" checksum="3DE54A8DCA2DBAD6" modified="2009-09-22" version="1">MTRAIIAFFLLFHFTMNSQQTQNPYQPKTYVEIKNPDWVKNATLYELNVRQFSAEGTFKAVEKELPRLKKMGIDIIWLMPVQPIGVVNRKGSLGSYYSVKDYLGINPEFGTEADFRSLVKAIHAQGMYVILDWVANHSSWDNQLATDHTDWYTKSRDGKFQSTPWRDYDDIIDFDYSKPELRKYMTEALKFWVREYDIDGYRCDVASFVPIDFWEHARSELDAIKPVFMLAEAEDKELHRKAFDATYNWTLWNILHQIALNNKSVKTLGEAYIAEHVSIFPKEGISMNFIDNHDKNSWEGNQYSNFGEALQAATVFTVMMDGMPLVYNGQEAGLDRSLKFFERDPIDWNNHPNEALYTALFALKHKNQALWNGSRGGEMVRIMNDKMDQVISFVREKNGDKVLTFINLSKENVHVTFDTSYDAGTYTNLFTAKTERVPQKMTLTMQPWGYVVLHRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X167</accession>
    <name>C6X167_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01737"/>
    <dbReference type="CAZy" id="GH115">
        <property type="family name" value="Glycoside Hydrolase Family 115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08180">
        <property type="protein sequence ID" value="ACU08180"/>
        <property type="gene ID" value="FIC_01737"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01737"/>
    <dbReference type="eggNOG" id="ENOG502Z7KK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004852_0_0_10"/>
    <dbReference type="OMA" id="PWYWFAD"/>
    <dbReference type="OrthoDB" id="166825at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970531" evidence="2">
        <location>
            <begin position="24"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67N" evidence="3">
        <location>
            <begin position="80"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GH115_C" evidence="4">
        <location>
            <begin position="670"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="839" mass="95894" checksum="220D963782D4BF9A" modified="2009-09-22" version="1">MMRCNLKKIIIAAVLVFSFELNAAEPFIVTTKSESTVVLKDASVKLAIYYDSNIDKGVLRAVNNLRSDLHKVTRDLPAFVTGFSAEKNSLIIIGTIGTNSVVDNLAKQKKINSKELLGKREKYLITNITTAEGVEAVLIAGSDKRGTIYGIYEFSRQIGVSPWHYWADVPVKKSEKLYFKKGVYTDGEPAVELRGIFLNDEEPALGGWARATFGGFNSKFYEKVFELVLRLKGNYMWPAMWGSAFYDDDVLNGPLADEMGIVMGTSHHEPMALAQQDWRRYIKKNNLPNVWDFNKNSKVLNEFWAEGIKRSNNWERLVTVGMRGDGDEAMEDGTNISLLENIVKNQRAIIEKATGRKAAKTPQVWALYKEVQDYYDAGMRVPEDVILLFADDNWGNVRKLPDLSKPLHKGGYGMYYHFDYVGAPRNAKWINISPIQRIWEQMNLTYEHEVKKLWVVNVGDLKPMEFPMSFFMDMAWNPKNFNADNLMQYTENWAAAQFGDKHSKEIARLINLYSKYNRRVTPEMLDDKTYSLENYNEFETVVNEYRALALDANRLYNDIPAEYKDAYFQLVLYPVDASSNLYEMYFNIAMNKKLAAENNPDANRYADLAKQKFEYDTQLAQKYNTEIAGGKWPHMMDQIHIGYKIWQQPDKNIMPEVKYVEENLNRKSKVFIENDGYVSIEAENFARAAGSSKIQWKVIPDFGKTKSGLTTLPQNAYPTSKDNIAVEYDIDFTSTGTFDVELLLAPTLNFNHNKGLRYEISLNGKNPQTINFNGHYKGELAQWQAEHIIRSVSKITVDQPGTHILKIKVLEPGIVFEKILINTGGLKPSYLGAPESNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X199</accession>
    <name>C6X199_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">FIC_01769</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806497.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01769"/>
    <dbReference type="EnsemblBacteria" id="ACU08212">
        <property type="protein sequence ID" value="ACU08212"/>
        <property type="gene ID" value="FIC_01769"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01769"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_0_0_10"/>
    <dbReference type="OMA" id="CFDYPGQ"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973579" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="22"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="43"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="270"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU08212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="835" mass="94489" checksum="A29F5E6D2C0AD32C" modified="2009-09-22" version="1">MKKLIISIGLLGILFTGNVFAQTETSGRTEYRQTHTKSTELKHTKLKVNFDYQKEQMNGEEWLTASPHFYPSDSLVLDAKAMLIHEVALDRNGSKTSLKYTYKDDMLRISLDKTYNRNQDYTVYIKYTARPNEVTEKGSAAITAAKGLYFVNAQGKDADKPTQIWTQGETEASSAWFPTIDKPNQKTTQEIYMTVPDKYVTLSNGLMKSSVKEANGLRTDHWVMDKKHAPYLFFMGVGDYAVVKDKWRNIPVDYYVEKEYEPYAKQIFGNTPEMLEFFSKKLNYDYPWSKYAQITARDYVSGAMENTTAVLHQESAQQKPGDLIDENRWEDVISHELFHHWFGDLVTTESWSNLTVNESFANYSEYLWNEHKYGKDFANYTLMEAAAGYFRDPSNVTKDLVRFNYHNKEDMFDGVSYNKGGSILHMLRNYLGDEAFWAGMNDYLKTNEYGTGEAHQFRLSLEKVSGKDLNWFFNQWFFGSGHPKISYTTTFEPVKKQVKVTVSQDQLGGNFQFPLAIDVYENGKATRQNVWVNAKEKTDFSFPVSKNPDFINVNADGVLLAEFTENKTPEQYFTQYSTSKEFLSRYKAVENAAENNSKNAVSVKTLVAALKDSNFRIRMKALSSLDLSKADQAKAALAEVEKMASNDPKTLVQGAAISALAKTKDKKYLPLFEKGMNAVSNSVKANSLAGISAVDPSRVLAFADKIDLEGASDDLMAELLPVIVKNKIEKQMPAIASTAAFYPFLKFQNPELGTVAEEGYNWIMSSDNLKATENITKILTQVKSQIGNNPQAKMMIVQILKDGLAKKMAVLKANPSSPTINKQVDLINDAIKSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A8</accession>
    <name>C6X1A8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806506.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01778"/>
    <dbReference type="EnsemblBacteria" id="ACU08221">
        <property type="protein sequence ID" value="ACU08221"/>
        <property type="gene ID" value="FIC_01778"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01778"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_10"/>
    <dbReference type="OMA" id="AAGAHEY"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="118" mass="13083" checksum="9CF85AF1724FBA53" modified="2009-09-22" version="1">MAILVAEDDELILKTIEHKLVKEGYEVILTRNGKDAIDKILETEVDLIITDIMMPFASGIEILSAIKIAGKNIPVIMLSSMGQEDVILNAFDLGAADFIVKPFSPNELMLRVKRITSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D1</accession>
    <name>C6X1D1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806529.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01801"/>
    <dbReference type="EnsemblBacteria" id="ACU08244">
        <property type="protein sequence ID" value="ACU08244"/>
        <property type="gene ID" value="FIC_01801"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01801"/>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_3_10"/>
    <dbReference type="OMA" id="PGVPYEM"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="415" mass="45695" checksum="15CE096E3AF54E8C" modified="2009-09-22" version="1">MKAVLITIGDEILSGNTLDSNSNFIAQQLKSIGIPVLKILTVADEIPSIRQALAEGFGITDLIITTGGLGPTKDDRTKTAFAEYFDDELKLDDATFEHLKNLMIKRKREHLIEINKDQAVVLSKAHVFQNENGTAPCQMIQKNGKTAICLPGVPYEVKPLLKDKILPYLRKKYALNHITSRIISVVDFPESLLALTIENWELALPANISLSYLPVGNRVKLRLTAVGDDAAQLENQLDAEAEKLKPIIGGHVIAWDGNDIQEILKEMLTSRNLTLSVAESCTGGELSRLITSVSGSSAYFTGSVVAYDYHQKIALLDVNPETIQNHTVVSAEVAQEMSSGCQQLFKTDIALSTTGVAGPNSDEFNNEIGTVYYSVRIKDVEQTNRLYLPHMERNDFAAFVSQRVLQDLVSLLLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F8</accession>
    <name>C6X1F8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA polymerase sigma-54 factor rpoN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_01828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806556.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01828"/>
    <dbReference type="EnsemblBacteria" id="ACU08271">
        <property type="protein sequence ID" value="ACU08271"/>
        <property type="gene ID" value="FIC_01828"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01828"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_0_1_10"/>
    <dbReference type="OMA" id="VTTQKFM"/>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="11">
        <location>
            <begin position="110"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="10">
        <location>
            <begin position="333"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="492" mass="56139" checksum="B6009E422B4CF66A" modified="2009-09-22" version="1">MLKQNLQLRLGQKLAPQQIQLMKLIQLHTLEFEEELERELEENPALEKVQEESNEEEYSTPDETFEEEGSESIDTDFDVNDYIFDDEPAYKTTSSNYSADDEEFDSGSLLTEGQSLYDYLLEQIHLANIDGDDLKVAEYIIGNLDNDGYLRREIKQLVDDLAFSQGIYTTPEQVVDVLENYVQKLDPHGVGARSLQECLLLQIEKKVSADKAVSLAANILRHQFDALTNKHYNKIIQKYDIEEEDLKDALEVISKLSPRVGGNFDTQTITINQEIIPDFVIQIKENKNGQVDVIPLLNSKNAPTLRVSDEYKDILTTYSHDKKSPDHKQAALFIKQKLDAAKWYIDAINQRQNTLLQTISAIVKLQKNYFITGDDKSLKPMILKDVADITGFDISTISRVVKSKYADTPNGIVYLKSLFSDSLTNDDGEEVSTKEIKNHLQEVISLENKRKPLTDDALVGLLKEKGYNIARRTIAKYREQLNIPVARLRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J8</accession>
    <name>C6X1J8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Recombination inhibitory protein MutS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806596.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01868"/>
    <dbReference type="EnsemblBacteria" id="ACU08311">
        <property type="protein sequence ID" value="ACU08311"/>
        <property type="gene ID" value="FIC_01868"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01868"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_10"/>
    <dbReference type="OMA" id="RLKNMNY"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="333"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="514"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="716" mass="82425" checksum="9870D6685044CA8A" modified="2009-09-22" version="1">MHITKDQLEELEFPELLAEISPFAYSPKTAQKIAGLRPFQIDEAEISLKKVSEFVSSFESDNAIPFDEYEDIEEELKMMIIENFRLDNVSFIKIKSITEQIGKLQRFLPVSGDLFLHLNNDIKDLEYKKEIIDKIDKVFNRFGDVKSEASPILKTLRTEISYARKTIQENFNRSLTALSSTDFLDDIRESIMDDQRVLAVKSGYKKRVPGRVLGVSKTGSITYIQPESVVKHHFKLREDLEEEKKEVDKILRKLTAEIAEFQPQLSDYQAYIFDLDLTRAKAKFAEKIGGILPKINRHKTLRLVNAYHPLLLLRNRAEKKDIYPQSFTLTEHNRILCISGPNAGGKSITLKTAGLLQLMIQSGILVPVHPKSEMFFFSRIMTDIGDNQSIENHLSTYSSRLKKMAGIIREADESTLLLIDEFGTGSDPELGGALAESFLEFFYNKKSFAIITTHYTNIKLVVEQLPNAQNAAMLFDEHSLEPLYKLEVGQAGSSFTFEVAQKNKIPAYIIDSAKKKVEHDIVNLDKTIVKLQQEKFEVEKLKTNLTEQKESTQNKKDNLEKLNEQLQQKLFNFQKLYEEEHRKLQFGNKIEGFIDSYIKGKSRKDVVTEFVKILEQEKFRKLGSDKDETKKMQVVKRKITQQLKKETIQEKIAETHEKLEDKRVKDRAVWLKIGQRVRISGSTSVGTIEKIDKNQKVTVNYGMFKTQISADELERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K7</accession>
    <name>C6X1K7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pectate lyase/Amb allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806605.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01877"/>
    <dbReference type="CAZy" id="PL1">
        <property type="family name" value="Polysaccharide Lyase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08320">
        <property type="protein sequence ID" value="ACU08320"/>
        <property type="gene ID" value="FIC_01877"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01877"/>
    <dbReference type="eggNOG" id="COG3866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_615041_0_0_10"/>
    <dbReference type="OMA" id="RMPRARN"/>
    <dbReference type="OrthoDB" id="660314at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PTHR31683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970539" evidence="3">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Amb_all" evidence="4">
        <location>
            <begin position="41"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="445" mass="46680" checksum="C8AEB66952F21591" modified="2009-09-22" version="1">MKKIFFIAACFLAVSTAHAQVPYQAVPEGYGAAATGGGTAAPVIVSDFASLRTNLTAAGPRVILVSGVINIPANQQISAVISNKSLIGLPGAKLVNENLSGSGILNLKNGSNNIIIRNLIFVGPGAYDNNGQDNLTNQGGTNVWIDHCEFQDGQDGNLDNVGQSDNITISWNKFTYLKPPVPGGSGGSNDHRFSNLVGSSATDKPADGHYSITYQSNYWGEGTRERMPRARNAQLHILNSYYYTSVPGAVGIGLGGGVSNSTVFVENTHFAKISSYFKNYVSSDGGSIAINFVNSLTGTSPVPGSMNIGTVSPPNYAYTVMPVADVAKYVADATCGAGATLQVSTAGVITPGQCSNMGTANISKAAVKLYPVPVKDILNIEVPGVKSSSMLVEIYAVDGKKVFTSSAPKMAGNRLNIDIGHLPKGAYYGRLQHGDRSFPLNFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M1</accession>
    <name>C6X1M1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-keto-D-gluconate 5-reductase</fullName>
            <ecNumber evidence="1">1.1.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.69" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806619.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01891"/>
    <dbReference type="EnsemblBacteria" id="ACU08334">
        <property type="protein sequence ID" value="ACU08334"/>
        <property type="gene ID" value="FIC_01891"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01891"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_10"/>
    <dbReference type="OMA" id="QANLMTI"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008874">
        <property type="term" value="F:gluconate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="261" mass="27993" checksum="C4FF9408C32D55F6" modified="2009-09-22" version="1">MEIFSLKNKNALVTGGTHGLGMAMAEALAIAGANLLITGTTPQKMEDALAYYHSKGYNARGYIFDVTDEVEAAKQVDQITVEVGGIHILVNNAGIIKRESALTMPVSDFRKVIDVDLVGPFIMSQLVVKQMIERNEGKIINICSMMSELGRNSVSAYAAAKGGLKMLTRNLATEWAKHNIQVNGIGPGYFATSQTEPIRVDGNPFNEFIISRTPAGRWGNPEDLAGAAVFLASKASDFVNGQIIYVDGGILATIGKPSNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q7</accession>
    <name>C6X1Q7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806655.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01928"/>
    <dbReference type="EnsemblBacteria" id="ACU08370">
        <property type="protein sequence ID" value="ACU08370"/>
        <property type="gene ID" value="FIC_01928"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01928"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_10"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="285" mass="31180" checksum="72DF7360D872290B" modified="2009-09-22" version="1">MKGIILAGGSGTRLYPLTIAVSKQLMPVYDKPMIYYPLSTLLLAGIKDILIITTPHDQQGFIKLLGDGSAIGCKIQYKVQPSPDGLAQAFILGEEFIGDDSVALVLGDNIFYGAGLPKLLASKTNVKGGCVFAYQVSDPERYGVVEFDDNLKAISIEEKPDEPKSNFAVPGLYFYDNSVVEIAKNLKPSPRGELEITDVNRIYLEKGELEVGVMSRGTAWLDTGTFDSLHEASEFVKVLEKRQGFKISCIEEIAYSKGFINREQLLQAAAKYGKSGYGDYLKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V1</accession>
    <name>C6X1V1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA methyltransferase, TrmA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806699.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01972"/>
    <dbReference type="EnsemblBacteria" id="ACU08414">
        <property type="protein sequence ID" value="ACU08414"/>
        <property type="gene ID" value="FIC_01972"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01972"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_2_10"/>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="469" mass="53879" checksum="DBC2EC52BB946E02" modified="2009-09-22" version="1">MRKSKKNIVLENIQLVSAGSKGVAIGKTNEGKTVLVSGAVPGDTVHARVKKSKSNYFEAEAIEIVERSPHRVEPKCVHFGVCGGCKWQNLSYEKQLDIKQDEVFNHIKRIGGFEDFETMPILGSDEQYFYRNKMEFSFSNARWLTQYEISSEENFGNRNALGFHIPGMWSKILDLKECWLQEDPSNYIRLAVNQYAVANGLEFFDVRNQEGFLRTLMLRQNSKGEWMVLFQLFRDEQENRVKLFDFLLKEFPQIKSLVYCINSKQNDSIYDQHVVTYFGEGFLMEEMDGLQFKIGPKSFFQTNYKQALQLYRKTLEFADLKGDEVVYDLYTGTGTIAQYVAKNAKKVIGIESVQEAINAAKEHAKLNGLDNCTFYCGDMKDIFNDEFLANHPKADVLITDPPRDGMHQKVVEQILKLAPEKIVYVSCNSATQARDMALMKDHYRLVKILPVDMFPQTHHVENIALLVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1X8</accession>
    <name>C6X1X8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ordered locus">FIC_01999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007839480.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01999"/>
    <dbReference type="EnsemblBacteria" id="ACU08441">
        <property type="protein sequence ID" value="ACU08441"/>
        <property type="gene ID" value="FIC_01999"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01999"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_3_3_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="38" mass="4457" checksum="2316C9CB8336D47A" modified="2009-09-22" version="1">MKVRASIKKRSADCKIVRRKGVLFVINKKNPKFKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z9</accession>
    <name>C6X1Z9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ordered locus">FIC_02020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806746.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02020"/>
    <dbReference type="EnsemblBacteria" id="ACU08462">
        <property type="protein sequence ID" value="ACU08462"/>
        <property type="gene ID" value="FIC_02020"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02020"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_10"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="23637" checksum="C789E541AD35DA70" modified="2009-09-22" version="1">MELTVFNTSGKETGRSVQLDEAIFGIEPNQHAVYLEVKQYLAAQRQGTHKSKERSEITASTRKLKKQKGSGSARYGDIKSPTFRGGGRVFGPKPRDYRFKLNKALKRLAKKSVLSQKMRDNSIKVLEAFNFDAPKTKEFINLNNALGFEGKKSLYILPEANKNVYLSSRNLPKTTVLTYNEISSYDLVHAGEIVFLEGAIEKFQENLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X211</accession>
    <name>C6X211_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase</fullName>
            <ecNumber evidence="4">1.16.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806758.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02032"/>
    <dbReference type="EnsemblBacteria" id="ACU08474">
        <property type="protein sequence ID" value="ACU08474"/>
        <property type="gene ID" value="FIC_02032"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02032"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_2_2_10"/>
    <dbReference type="OMA" id="LYLQTHN"/>
    <dbReference type="OrthoDB" id="1742631at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00819">
        <property type="entry name" value="DPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="158" mass="18069" checksum="A5872C3D8E30724E" modified="2009-09-22" version="1">MKNATIIGLQETDCTAIAEKLNELLADYSVFYQNTRGAHWNIKGNDFFTLHPKFEELYNNLVLKIDEIAERILTLGAVPNHNYSDYLTLSTIKESREVSDGAKCVENILASFKIVIDLQREILDMTEEAGDEGTNSQMSDYITEQEKEVWMYNSYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X217</accession>
    <name>C6X217_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806764.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08480">
        <property type="protein sequence ID" value="ACU08480"/>
        <property type="gene ID" value="FIC_02038"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02038"/>
    <dbReference type="eggNOG" id="ENOG50334XX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169686_1_0_10"/>
    <dbReference type="OMA" id="CTKETVE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="110" mass="10162" checksum="B0CACCD8FD109E7A" modified="2009-09-22" version="1">MKKSFFVAGIAALALVACTKETVETASAADSTAVAAVDSSAVVADSAAGVVDSAATVTMDAAKDAASATTAAGAAAAKAAAEGAGEAATGAANAAKDAAKDAKDAVNDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X225</accession>
    <name>C6X225_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MazG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806772.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02046"/>
    <dbReference type="EnsemblBacteria" id="ACU08488">
        <property type="protein sequence ID" value="ACU08488"/>
        <property type="gene ID" value="FIC_02046"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02046"/>
    <dbReference type="eggNOG" id="COG1694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142229_0_0_10"/>
    <dbReference type="OMA" id="MADVLWV"/>
    <dbReference type="OrthoDB" id="1760741at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11531">
        <property type="entry name" value="NTP-PPase_BsYpjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012359">
        <property type="entry name" value="MazG-related_YpjD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42692:SF1">
        <property type="entry name" value="PTHR42692:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029904">
        <property type="entry name" value="UCP029904_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="108" mass="12383" checksum="5A1E9A340F370753" modified="2009-09-22" version="1">MEITKLQNEVDEWIKTVGVRYFNELTNMAMLTEEVGEVARIIARSYGEQSEKVSDQSKDLGEELADVLFVTLCLANQTGTDLQKAFDAKMKKKTERDSLRHQNNEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X236</accession>
    <name>C6X236_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">OmpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">FIC_02057</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806783.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02057"/>
    <dbReference type="EnsemblBacteria" id="ACU08499">
        <property type="protein sequence ID" value="ACU08499"/>
        <property type="gene ID" value="FIC_02057"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02057"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031536_3_0_10"/>
    <dbReference type="OMA" id="HIANSWQ"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973612" evidence="13">
        <location>
            <begin position="22"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="14">
        <location>
            <begin position="347"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU08499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="474" mass="50734" checksum="1BF461B638C87F89" modified="2009-09-22" version="1">MKNLKLGISALALTVATTVFAQTTSNPWLIGVGAHGVNHAAAGGGVGDVFATAFGGGDGGELYNINNFTITPPLSKLTVARNINRLLVLDWQTSVGNVDNKKIGMGKEFFLMTGLGLQFKFNGLWDEESWFDPYLRVGANYLRHDYTGVNFPLTDSNGEVISGFADNTPNSQRRADHFALATGLGSNFWITKNFGLGVQGDYVSTPIDNSTIANFWQASASLLFRFGNTDRDKDGILDKDDLCPDTPGLAEFQGCPDTDGDGVPDKDDQCPDVAGPVENNGCPWPDTDGDGVVDKDDACPEVAGPAENNGCPWPDTDGDGILDKDDACPTVPGLAQYNGCPKPQEAWADDATKALDNILFNFDKATIRPESKEKLDAAAQIIKDSQGKFLIIGHTDKKGAESYNLKLSQRRAGAVVDALEARGVADSSLKSMGVGEQDATVPETASNAERLKDRKVVVKPADAATWDSMKKRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X271</accession>
    <name>C6X271_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Catalase</fullName>
            <ecNumber evidence="1">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02097"/>
    <dbReference type="EnsemblBacteria" id="ACU08534">
        <property type="protein sequence ID" value="ACU08534"/>
        <property type="gene ID" value="FIC_02097"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02097"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046417_1_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="348" mass="40176" checksum="7F30783E47459BEC" modified="2009-09-22" version="1">MQNTVMKQFLKYSPQMDALSPEEEQLLAEDLPLIEQAVKASRKVNKTPHHTRNAHAKAFGFVRGHFVPVKNEAADFRQLLDGANLGVIIRYSHPNFFVLGGKWEYPVYGCSIKIYNKDAPVSVKYPLVNLPVFITNSVSKFLNIHIKANRFFIAAGRNYFLAALKIPALLRAGLSLFWDRELASILRNMLKVLDIERQFIPTYDFHSIGCFRLGEKVAKIRLKPNFTLPVEKGNDLEQAKLLRDYFQANELSLDFQVQLATDQKKTPVNNLLKMWREKHAPFVTVGKIILMRQDISNHETEDYENLSFNPFENDGLLQPVGRMQQVRRKIYNVSIRTRQQLNQKNHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X273</accession>
    <name>C6X273_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phytochrome, two-component sensor histidine kinase</fullName>
            <ecNumber evidence="8">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the phytochrome family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806820.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02099"/>
    <dbReference type="EnsemblBacteria" id="ACU08536">
        <property type="protein sequence ID" value="ACU08536"/>
        <property type="gene ID" value="FIC_02099"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02099"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_1_10"/>
    <dbReference type="OMA" id="ECHRGRI"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="6">
        <location>
            <begin position="136"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="519"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="729" mass="82066" checksum="A8D889B3856C1C09" modified="2009-09-22" version="1">MNLADCHEEKIHVSGHIQDFGYLIGLDPDTQFIRLFSQNIFEIIPVDESFIGRTMQDAPEVFGALLKSVVLSNLDFATMKDVDVFLDKIEIGNATFHLTIYRYTGIIFLELEEMSESFQQKTFVSKKYESISNAPTSGEIWEQLLNVVAETCDYDRVMIYRFLDDGSGKVIAEKVKNEVDSFLHLHYPESDIPRQARELYMKKRKRIFSNVYSTPVPIISALEKPVDLTYSTLRAMSPVHGQYLKNSGVSSSFSTSIVVGNKLWGLVTCQNTEPKHIDLVNRIRCEVFTVIASNAYTSYKSQQSLKDSAELDSKINLLKSRLQKHENLNDSLFSNIDEMRKYPSADGLAIVIADEIRTSGTVPDDANIMKIVRYARENPPQNFYFTNDFGNVSDGKLGNIPNAAGVIFGFTDDKRNELLIWFRGAIDTQVLWAGNPSKETSETILNGDQHYVMSPRKSFATYIESIKGKSEPWKNRDIFAAKKVVAAILETTYSQFKKVQDLYEELKNLNEELDSFSYTISHDLGTPLTVMKLNAQLLERAHHDNPEVGKRVASILQEILGMEDMMRGVLQLSRAKSTEIVVKEVETAKIIRKICLDAQLTLSQTTEIIIGKTPSVLADETMVMQAFLNIIGNAVKYSSKSAMPKVEIHGAEQRDQVVYTVKDNGIGIPAEAQEKMFKIFNRMDNAKGFQGNGVGLSIVFRIMGRLGGSISYQSKEGEGTTFTLIFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X278</accession>
    <name>C6X278_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806825.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02104"/>
    <dbReference type="EnsemblBacteria" id="ACU08541">
        <property type="protein sequence ID" value="ACU08541"/>
        <property type="gene ID" value="FIC_02104"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02104"/>
    <dbReference type="HOGENOM" id="CLU_2057904_0_0_10"/>
    <dbReference type="OrthoDB" id="1915424at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="119" mass="13421" checksum="A95F77F235301651" modified="2009-09-22" version="1">MKLLCAYLLTGLVIFAGTKNLLFLVDYQVNRDYYELICENQNRPELDCHGKCQAGSDSKQSSAGFSFSHFSFNFYASAEAAIPERTETLFVNGEKIGEHMSHFRYAVPQHVPNPPPDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X287</accession>
    <name>C6X287_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806834.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02113"/>
    <dbReference type="EnsemblBacteria" id="ACU08550">
        <property type="protein sequence ID" value="ACU08550"/>
        <property type="gene ID" value="FIC_02113"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02113"/>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031281_4_0_10"/>
    <dbReference type="OMA" id="ICGGVQT"/>
    <dbReference type="OrthoDB" id="1776069at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972238" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="49"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="184" mass="19256" checksum="0026EBF6FD846AD3" modified="2009-09-22" version="1">MKKSVFILGALLLVLASCEKSETVTAANSDTTTEAVSHGQDGVQDDESNPNIVQLASKNPDLSTLVKAVQTANLVTSLSNTGPFTVFAPLNSAFDKLPAGIVDGLLEPEQADALSDILSYHTYVGVIKEDQMTDGQSLGMVNGKNIKITMVDGKPVINGKAKIVATVPASNGVVYAIDEVLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E4</accession>
    <name>C6X2E4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ordered locus">FIC_02171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806891.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02171"/>
    <dbReference type="EnsemblBacteria" id="ACU08607">
        <property type="protein sequence ID" value="ACU08607"/>
        <property type="gene ID" value="FIC_02171"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02171"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_3_0_10"/>
    <dbReference type="OMA" id="PGMSRYI"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="60" mass="7004" checksum="227D7537534E327B" modified="2009-09-22" version="1">MAKKGNRVQVILECTEHKETGVAGMSRYITTKNKKNTTERLELKKFNPVLKKYTLHKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H6</accession>
    <name>C6X2H6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil-DNA glycosylase</fullName>
            <ecNumber evidence="2">3.2.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806923.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02204"/>
    <dbReference type="EnsemblBacteria" id="ACU08639">
        <property type="protein sequence ID" value="ACU08639"/>
        <property type="gene ID" value="FIC_02204"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02204"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068835_1_0_10"/>
    <dbReference type="OMA" id="HVPKRYW"/>
    <dbReference type="OrthoDB" id="659732at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023875">
        <property type="entry name" value="DNA_metab_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025404">
        <property type="entry name" value="DUF4130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13566">
        <property type="entry name" value="DUF4130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03915">
        <property type="entry name" value="SAM_7_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4130" evidence="1">
        <location>
            <begin position="85"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="30417" checksum="CDEE1521E08E6241" modified="2009-09-22" version="1">MTTLVYDGSFGGLLTAVFEVFEYRFHLAEIISKENFHNETFFSEVHEVLTDENKADRVTKKLEKNLGKSGVKQLLLVYLSEMPNSGNLILSAVRQSIKNPEQNILQNFGDRDIMDIAKICKSMSREIHRLHAFVRFEKLEDGMFFAKVEPDFNVLAVGFKFFRDRYADQKWMIYDLKRKFGVIYDLNSTEFFYPENDQLYALENSRNMHHDEEKKYSRLWQRYFTKTNIVERKNMKLHIQHVPKRYWKYLTEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2I6</accession>
    <name>C6X2I6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Imidazolonepropionase</fullName>
            <ecNumber evidence="2">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806933.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02214"/>
    <dbReference type="EnsemblBacteria" id="ACU08649">
        <property type="protein sequence ID" value="ACU08649"/>
        <property type="gene ID" value="FIC_02214"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02214"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041647_0_0_10"/>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="69"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="409" mass="44965" checksum="8456A5E7E088E8EE" modified="2009-09-22" version="1">MKLIGPFKQIVTLAKLPLRGKLSDEQLEIIEDGGILLENGTIAKVQNFNDLKAEFPHVEIEKIEGEQICLPAFTDCHTHIVFGGNRANDFAMRNAGKTYLEIAESGGGIWSSVQHTRNASEEELLTRTLERIKFLIAQGITTIEIKSGYGLDVENELKMLRVIKKAQTLTKATLVPTCLSAHLKPRDFEGSSEEYLNFILEEILPQVKAEKLAERVDIFIEKSAFLPEESKSFLLKAKEMGFEITVHADQFTSGSSRIAVEVGAKSADHLEATVDEDIEYLATSETVAVALPGASLGLGEKFTPARKILDANGILAIASDWNPGSAPMGNLITQTSILATFEKLSTAEVLAGITFRSAFSLNLKDRGTLQTGKKADFVTFKTDNFQNVLYQQGSLKPRSIYINGEKQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M1</accession>
    <name>C6X2M1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806968.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02251"/>
    <dbReference type="EnsemblBacteria" id="ACU08684">
        <property type="protein sequence ID" value="ACU08684"/>
        <property type="gene ID" value="FIC_02251"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02251"/>
    <dbReference type="eggNOG" id="ENOG5033QHY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258617_0_0_10"/>
    <dbReference type="OMA" id="KIVHANQ"/>
    <dbReference type="OrthoDB" id="73798at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1293" mass="146799" checksum="E8C1D634809D3659" modified="2009-09-22" version="1">MEPLYSLLTFPQHFTAGRLHFNIVVLPRNINLQKPINAGTPAFVDAEFQFETKIINHLDGLPLFSTVTHTEVPTIAEPPSAKKSVIEEVIRQMEQNDGLRISEDPLQNKDIGARAQMQKYALKNVSIKKYLPQTYRNSFNFTSARTRFAVTDDEYECIIKNKDKKLTDELTDRRYISWGKLIAFILRNPFLAEKAGLIYKASIPVSGELLEKGGWLFTQFAADSQFSSINSSVYAARIPALTEERDLFAAVLFPLNEIASNNATYDAVMQESILYNDGFAKIVHANQPVNQDLLQESDTSNPPVKDVGLRLGWDDEQLTIWGNRQLRQKDEITELPIDAPLGVFGYKIDVRHLGSSRWFSQNQVRTSQDIVMQNGEVLAAMDQTFELPTEVHPSSHGNTMDEGFWLPMYFTSWNGKSVVLPDKEAHEIHHLDKARVPVNGLSSGNALNLEPKKTFHPYYQDPEHVIQLLYGHDYQFRIRLMDISGGSPSINSEPARGQKPVADAHFRRNIKAGALNILNIKDFFDNQNTSLVKDPGTLENIIDEDGILRIKRPDLSYPSVLYTDKYRDAAGLLKDKINLITVPANPNDRTQHSIGLPDPDVNTFKVLVEVKLIEMDNILSENGREAFILWQEKTFTLLSDAEVQNYDLETEINIIYRDFEQLDLENSFTDDGNTNGLILPTSRELRLTFIPIVDFADDDYAAKFVKFGTPLMLTSFKAATREPDLLSPIKGGLRAFYLQPEDRPELSAVNKIKMNVTKTVGSSAPVELKRLAKALDLTAHQLTLEGSPGQRVQFGVSNEIRHSLSPESGSVTLSSVRELFGRWIIALDFSLLRDWAWQGLEPDSFTIERTVRDHDTEAQEIGSIQLKDVANMQMLRQPDRSNSRIMFLDCIDPKKYQKNFPRELSVEYTLKAHFKNDLTVAEIPEPLHIELPVTVIPHQIPKLVSVGVALSPYQYDEENYRYSTERQKFLWLEFDEPPRDPMDTYFARVLASSPDPYLCRMDKELITTLHEDLPFNINEEKIREIIPGMTNDFAGMGVMQELIRENGSNAKRFLLPLPQGLHADSDELFGFFTYEIRVGHRPELWSTAQARYGRPLKVNGVQHPAPELSCTAIRSEVRTPLGKKRYIVLSAPHANAVLNGRNVTAFPPNTSLWYSLYTQVMQADGKSFRNILIDSGPMYYQPKESKNSQTGYIKESGNRFGTARLELRDIGDKLEALGLPRSNNLSAVAVEIFPLNNRWQMANNQKRVNEASYIQEYLENRSQLNPLTDLLGQHRIYRSSKLTSITEVCCEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R5</accession>
    <name>C6X2R5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807012.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02295"/>
    <dbReference type="EnsemblBacteria" id="ACU08728">
        <property type="protein sequence ID" value="ACU08728"/>
        <property type="gene ID" value="FIC_02295"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02295"/>
    <dbReference type="HOGENOM" id="CLU_1576152_0_0_10"/>
    <dbReference type="OMA" id="EMEYNES"/>
    <dbReference type="OrthoDB" id="1625064at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970568" evidence="1">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="17386" checksum="B1F8DAF4CF91F28F" modified="2009-09-22" version="1">MKNLVFAAIAATATLSACSTVSSIMQNTFPYTANVLVTSGSPVNVQLSGISAAQSINQLTGAGANVKDVRVSSATMSVDSNTSMSIFKSVKVYLSNSGSNEVLVASRDAVPDNVGSSLSLDANSTQTLDNMMKSGAVQAHIVYVLKKSPTSDVSLKTSISFSSVPITNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S5</accession>
    <name>C6X2S5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807022.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02305"/>
    <dbReference type="EnsemblBacteria" id="ACU08738">
        <property type="protein sequence ID" value="ACU08738"/>
        <property type="gene ID" value="FIC_02305"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02305"/>
    <dbReference type="eggNOG" id="ENOG50335GZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091991_1_0_10"/>
    <dbReference type="OrthoDB" id="1889045at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970571" evidence="1">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="29784" checksum="564E7E4842F0C68F" modified="2009-09-22" version="1">MRTKLLLLSLLLTALSAYSQEYIFGKVRSEFGSELPNAVIINTRTDEMVNSDKDGNYMISAKPSDELRFVKSGYERTSAKISIDNYSQPLNISLTKSVYLIEEIELAFQATGNLKKDVKSLDPPRRVVALNSSMDSYMKTPPAQPSPKLTTSSAFAPKNLGAGQMDLLGLASAVSELFGKATKDPVTTATYAETQEFYRRIKTTLDLSFYTKQGWDEEEIDRFLLYADRNFSLAKKYRKSFNVAAISFDMKMAYQEYIKTHKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X351</accession>
    <name>C6X351_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin-protein ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807148.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02431"/>
    <dbReference type="EnsemblBacteria" id="ACU08864">
        <property type="protein sequence ID" value="ACU08864"/>
        <property type="gene ID" value="FIC_02431"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02431"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_3_1_10"/>
    <dbReference type="OMA" id="NDIYWRD"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="237" mass="26275" checksum="E70B4836B085C420" modified="2009-09-22" version="1">MAGLFYLKECKSTNDEISTFLHSESTDLTAVYTFHQTNGRGQYGNMWESAPDLNLAFTVAVPVADFGGGSTFVNFRTAALLTDFLAKLTNVKVEIKWPNDLIIKNKKIGGILSEQKNVDGKTFFVIGIGLNLLQENFENLPKAGSLLTQTGVALDPDDTAHSLFAVLGGLKEVFSESELMETININLYRKDAVSVFELNGVRQNGIIKYVDDEGFLWVDLESGGTQKFFHKEIELLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X383</accession>
    <name>C6X383_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein ftsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02463"/>
    <dbReference type="EnsemblBacteria" id="ACU08896">
        <property type="protein sequence ID" value="ACU08896"/>
        <property type="gene ID" value="FIC_02463"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02463"/>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064655_1_0_10"/>
    <dbReference type="OMA" id="NYKAFFQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="292" mass="33160" checksum="E0CB92E3A163B1BF" modified="2009-09-22" version="1">MKRFNSKPMEKVTVNLTKTTHPVYFIDEKDIREIVKKSNPSKKVGDINIPELEKKLNQLPAVDSANVYLNLNGNLNLDIRQKVPAFRLNKDGRDFYVDTKGVEFPISKNYSFPCMLVMGDVDKSEYTKVAELVDKIDKDDFSKKYFIGISKEKGGYNLLTSQGNYKVEIGDLENINLKVKGFKTFVEKFLIYQQPEKYTRISVKYDNQIVTTLNPHFEENDSLINIGKREMAKVPNLAQQKQSLAGVPKSVRNSAPAKPKPKAEKPKEVVAKKTAEKAAKTTSKPKPKVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X394</accession>
    <name>C6X394_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraZ</name>
        <name evidence="10" type="ordered locus">FIC_02474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02474"/>
    <dbReference type="EnsemblBacteria" id="ACU08907">
        <property type="protein sequence ID" value="ACU08907"/>
        <property type="gene ID" value="FIC_02474"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02474"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_0_1_10"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="159" mass="17962" checksum="525985C1B187E078" modified="2009-09-22" version="1">MSQMKNFIGTYECKIDDKGRLKLPSSLVKQMENFGGDAFVVKRSVFQSCLEVYPMAGWEKLMEKINGLNRFQKKNADFIRQFTAGLKTVEPDNVGRLQIPKDLVGFAKLKKEVVITSAGGLFEIWDKDAYESVIATSEEDFAKLAEEVMGDLSFTEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D0</accession>
    <name>C6X3D0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807227.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02513"/>
    <dbReference type="EnsemblBacteria" id="ACU08943">
        <property type="protein sequence ID" value="ACU08943"/>
        <property type="gene ID" value="FIC_02513"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02513"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_1_10"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="322" mass="34905" checksum="9A52B9917DAC10A2" modified="2009-09-22" version="1">MALVDLSKQVALGVDIGGTNTKFGIVNHRGEILEKGRMRTENFEKPEEFIDALYNEVAPHLAKHCTHNQFDGIGVGAPNANYYTGTIEQAPNLRWKGIIPFAELMTKKFGVPCKMTNDANAAAYGEMMFGAARGMKDFIMMTLGTGVGSGIISGGKLIYGHDGFAGELGHTIVKPGGRKHWSTGSEGSLEAYASATGIAITAKKMRAEFPESMLNDYPEEAINSKVVHECAKKGDPTAIEVFRYTGQKLGEALANFVMFSSPEAILLFGGVIKAGDFILKPTKLHMERNLLPIFRNKVRLVFSELDEADAAILGASALVWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E8</accession>
    <name>C6X3E8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FeoA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02531"/>
    <dbReference type="EnsemblBacteria" id="ACU08961">
        <property type="protein sequence ID" value="ACU08961"/>
        <property type="gene ID" value="FIC_02531"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02531"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_12_0_10"/>
    <dbReference type="OMA" id="EARFIIV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="91" mass="10584" checksum="E4E48FA7846EDE4C" modified="2009-09-22" version="1">MQRKIIALRREKSDKLCCFPRNANGRIVGYQNDDLKMPSKIIEMGLLPETAFRILYQAPFRGPLYVEFGDEKSRIALREEEARFIIVQPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I8</accession>
    <name>C6X3I8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807285.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02571"/>
    <dbReference type="EnsemblBacteria" id="ACU09001">
        <property type="protein sequence ID" value="ACU09001"/>
        <property type="gene ID" value="FIC_02571"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02571"/>
    <dbReference type="eggNOG" id="ENOG5033BCQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1842154_0_0_10"/>
    <dbReference type="OrthoDB" id="1581071at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU09001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="139" mass="15617" checksum="9106A088D4FDA8C9" modified="2009-09-22" version="1">MIVGDYSLAAPDNTVDFKVNDIKNDVIFRSIDGKKVSALNTSAIDDKVLVIIDDVLKPLFVQMIGKMGSGLSIFVYDNWKDGKLIIDPYKPGKFQVEVNNDIFKWQTPLISLLDEKSCSIDQMDFPANYIFCPIHGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N6</accession>
    <name>C6X3N6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FUSC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782171.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00566"/>
    <dbReference type="EnsemblBacteria" id="ACU07024">
        <property type="protein sequence ID" value="ACU07024"/>
        <property type="gene ID" value="FIC_00566"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00566"/>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013315_0_1_10"/>
    <dbReference type="OMA" id="YFIAQDI"/>
    <dbReference type="OrthoDB" id="1338660at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="753" mass="86356" checksum="AD14D4B158C9585F" modified="2009-09-22" version="1">MNYATELKKFATSQYIYSAVRITLAIVIPSIILAYFGLLQEYFLFPLATSFVGLTDQPGPFIRRRNSLVLAVILFFFVALITSVIHHFPVLIYLELILFGIFFSMIGVYGQRLAAVGSLSLVVMAIFADGNMTSGELSKIMITFLGGALCYLAVFLAVSKIQPYKLAGQMIGENYLELGDYLKIKSKFYLENPNFEELYLQVIAQQVKIKNLQEETRETVFKTRKIVNESTTTSRLLMLMFLNSIDLHEKLMTSESDYNKIQESFGDSGFLQSISTYLGLLAEELANIGIALQSGAKARPLKDIDAELDKIYEEYFDLRNRKLSASNLENFMILRIILVRITSISDEIGTIYKIFMQDKKLAKSLSTGLDLGKFLPREQKLNYKVLASNFSLKSSHFRHALRVTIALLVGYTISKLSFLGIGHSYWILITIIAILKPAYATTKHRNLLRLYGTIVGAVLAYILLLSVTSNSVLFALLMLSMIMCFSFLKAQYFWAVLFMTIYIFLTFNFLNPGNINMIFKDRIIDTAIAGLVAFGVSYFVFPVWEHTQNLDLMKKSSKSNLRYFKAVIDIFLAQKIGVEDYKLRRKDAVIDLANLSDNFQRMISDPKNQQKQMEQIHQFVNTTHLLTAYIASLSQYTKTAREYPEIDFRSWALKISAELLRTSLILEQKKLRQEILRESKLKPEDSVHKLLEKRKKEIRENEISDRRDPNRITHLTELKNLREILELIYDVAREQRKVAEHLEPEIQSTTVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P8</accession>
    <name>C6X3P8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M16 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00581"/>
    <dbReference type="EnsemblBacteria" id="ACU07036">
        <property type="protein sequence ID" value="ACU07036"/>
        <property type="gene ID" value="FIC_00581"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00581"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306466_0_0_10"/>
    <dbReference type="OMA" id="EFNRGQD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="258"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="740"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="966" mass="110144" checksum="AFB74867002588AE" modified="2009-09-22" version="1">MNAINLGALTMTEPQAFETKNITDPQGYTYETVLNDKNAVRIYTLKNGLKVYLAQNFDAPKIQTYIPVRTGSNNDPSDNTGLAHYLEHMMFKGTSKLGSADWQKEKPLLDEISALYEQHKAEIDPQKKNEIYRKIDEVSQEASKYAIANEYDKAISSLGASGTNAHTWLDETVYKNNIPNNELEKWLKVEKERFSELVLRLFHTELESVYEEYNRAQDNDARLVNYELMDALFPKHPNGQQTTIGKPEHLKNPSIVAIHKYFDSYYVPNNYAIVLVGDLDFDTAIKLVDQYFGTFEYRELPVRKMVTEEPMTKIVERTVKSPSAPRLQLAWRTDSYGTHDARLAEIVANLLSNSGESGLIDININQSQKALRAMAYVSPFKTYGNFSMVIVPKNEQTLDEARNLLLEQIELIKKGEFQEWLIPAIINDMKIHRMQATETADGLATVLYGAYINNQSWQQELEEINEFSTITKADVVKFANDFFKDNYVAIKKEKGVNDKLVRVENPGITPIKLNKDAQSPFLKAIMTEKSADIKPEFVDFAKAITTAKVDTKKVSFIENKCNDVAQTYFIFPFGNDHDKELSLAAQVLQYLGTDKLSAEELKKEFFRLGISHDFRTSSNQMIISLSGLEENMPEGIALLKNWMQNAIPDQKVYDENVKTILESREIAKKDKARIMAALSNYAKFGKISRFSDVVPEARLKQIKSEEMTAKMQNLLSMPYQIFFYGNDFNTFKNYVTPFIETENSKVPARKIYPQPATEGKVYFTEYDMVQTEMSKVAKAGNVNPKNFGKINVFNEYFGRGLSSIVFQEIRESKSLAYSAYVSYASNSEINRPDYITTYIGTQANKLPQAVAAMDELMAELPQVPAQFENARNAALKQIAAGRINRTNIFFNHLNLQKLGIDYDLRKDIYAEIEKLTMADVTNFYNEEVKPLKYNTALIGKKENLDLDAIQKMGAFEEVTLEQIFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S6</accession>
    <name>C6X3S6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782211.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00609"/>
    <dbReference type="EnsemblBacteria" id="ACU07064">
        <property type="protein sequence ID" value="ACU07064"/>
        <property type="gene ID" value="FIC_00609"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00609"/>
    <dbReference type="eggNOG" id="ENOG502ZCF0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084837_0_0_10"/>
    <dbReference type="OrthoDB" id="1915696at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="256" mass="28802" checksum="1701F7F2D3F68349" modified="2009-09-22" version="1">MTEQTTHIDVGQSKILNLDADDQGNFIAFTDTKTVITNEHNLKIDIEIRFPIIRRLNNETFLIADSRTDNSVNGYIYNFGGQLVKSFLVGDGIENIVVHRDKIVITYFDEGVLGDDGPNNDGLAVFNFSGGQIFGFNSSKIYGNILDCYCICMHGANEILFYAYTDLKVFELNLDTFKVESFETPNDFLGTSAISSTADKIIFHSSYDDKRSFFLWDRNKSEVIKFGDYSPRLTGIKNGKFLIYGDSGYTIVSPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T0</accession>
    <name>C6X3T0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782215.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07068">
        <property type="protein sequence ID" value="ACU07068"/>
        <property type="gene ID" value="FIC_00613"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00613"/>
    <dbReference type="eggNOG" id="ENOG503460M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1537816_0_0_10"/>
    <dbReference type="OrthoDB" id="2049258at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="174" mass="20503" checksum="1B48FAFFE139C83B" modified="2009-09-22" version="1">MHTVILTIILIIIPVFIFGQTEDIDSRKYHPAKEIFEIKYEKVHYPKFLKSQIRTIGNKVILGEMKFLEFNEESDEKTKIILKSGLLDPYLINGTYHLKIGWIDELTLLNPNSQTKRFKFWVFYTVHNNPLLNSVNPHEYYIEFYNAKATENTTFINFMENAHLTLIKYGGIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V6</accession>
    <name>C6X3V6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00639"/>
    <dbReference type="EnsemblBacteria" id="ACU07094">
        <property type="protein sequence ID" value="ACU07094"/>
        <property type="gene ID" value="FIC_00639"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00639"/>
    <dbReference type="HOGENOM" id="CLU_1213348_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="228" mass="26388" checksum="EA5793210E377392" modified="2009-09-22" version="1">MNFCAKLKICASIAPPSQSPETLHESAYPKPNKTLMKRIYLIFLLIIAQTVFSQKDNRIENIGEATSQLLIKGDDIDNFKYAIKIQSLYPNEDFSKFKDSPAEVILNMLHGAELELPKAWNEVVKESGEYKIDKTSKYVFTYSHKMGVDNYIATSVIESQSKYYAFSYNLLQWGEDIYISRFYKKVMEFETVEQIDSNPFVIIHDEMQKELNEIDENHSEEILIGPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X6</accession>
    <name>C6X3X6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase subunit C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00659"/>
    <dbReference type="EnsemblBacteria" id="ACU07114">
        <property type="protein sequence ID" value="ACU07114"/>
        <property type="gene ID" value="FIC_00659"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00659"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_10"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="25215" checksum="7D44C579F2332EB0" modified="2009-09-22" version="1">MHYEILKPIYMSLVGKKFPNIAIDAMSEMGDDLKINIFEEATQNQQKVLLFWYPKDFTFVCPTELHAFQDALGEFEKRNTKVIGASCDTNEVHFAWLNTSKDNGGIEGVTYPILADTHRQLANQLGIVDQDFEFDEEGNEFFTGSNVTYRATYLIDETGKIFHEAVNDMPLGRNVKEFLRLIDAYTHVQKHGEVCPANWEEGKDAMQANRKSTAEYLASQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X7</accession>
    <name>C6X3X7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Haem_bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00660"/>
    <dbReference type="EnsemblBacteria" id="ACU07115">
        <property type="protein sequence ID" value="ACU07115"/>
        <property type="gene ID" value="FIC_00660"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00660"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120447_1_0_10"/>
    <dbReference type="OMA" id="FYLPAHP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025992">
        <property type="entry name" value="Haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14376">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01235">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haem_bd" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="174" mass="20397" checksum="2ECEDD43B13E4188" modified="2009-09-22" version="1">MARFSYFHMINYFMKKILAVLFVLFVLIQFFPIDQKNPEPTPGMDFLTIKNTPEKTANIIRSSCYDCHSNESTYPWYANVQPVGWFLKSHIDEGRKKLNFSTFATYEPKRQAHKLFEARELVENGEMPLDSYTLGHPEADLSESQRQELIKYFNFVESDIRLLNELPAEKSTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X453</accession>
    <name>C6X453_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Octaprenyl-diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.1</ecNumber>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782337.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00736"/>
    <dbReference type="EnsemblBacteria" id="ACU07191">
        <property type="protein sequence ID" value="ACU07191"/>
        <property type="gene ID" value="FIC_00736"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00736"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_10"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="323" mass="37404" checksum="8FF3E058064337ED" modified="2009-09-22" version="1">MHFLEEYQEIVTKAVEKYTFKDKPTELYDPMNYIISHGGKRLRPIMVLMANDMFGGDIQKAIKPALAIEFFHNFTLIHDDIMDEAPLRRNKPTIHTLHGLNAGILSGDALLLKSYKFFEDLEPELFKACIRVFTHTGLLLCEGQQYDINFETLGDVTFNDYIRMITYKTGVLTASSFEIGALIAGSDFKDAKAIFNFGKNLGIAFQIMDDYLDVFGDQEQFGKKHAGDIYENKKTVLYLLAKEHGTEEEQKELDYWYAKKTDNVDKVYSVEKIFRRTKVDEKTLHLIQKYNEIAQGYLNRINVPDEKKKPFVELANYLLRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X454</accession>
    <name>C6X454_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSCFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782338.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00737"/>
    <dbReference type="EnsemblBacteria" id="ACU07192">
        <property type="protein sequence ID" value="ACU07192"/>
        <property type="gene ID" value="FIC_00737"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00737"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075057_0_0_10"/>
    <dbReference type="OMA" id="IMMDELR"/>
    <dbReference type="OrthoDB" id="533061at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014982">
        <property type="entry name" value="GSCFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08885">
        <property type="entry name" value="GSCFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSCFA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="317" mass="37034" checksum="96B82A4183C59031" modified="2009-09-22" version="1">MKFRTEVHIPASETKIETEDQVFSVGSCFATEMSELLAKGQIQTLNNPFGTLFNPYSVNFSLKKLHGSAFYTEADLIKYNDEIISLDHHSQFSSRFLHKTLDAVNEKIEEGNRFLQNTKWVIITYGTSFIYEFLPKNKLVANCHKIPGKFFKKRLLTHLELTDSIYETVTSLKDICEDNVQILFTVSPVRHTKDGMAENNLSKAKLISAIHEILPQFENCHYLPVYELMMDDLRDYRFYKEDLIHPNTQAVQYIWEKFSQAYFSQETMDFVEENFKIGKALEHEPSDETDPKYQEFLQNLNKKIEAQQAKVKHKIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X458</accession>
    <name>C6X458_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00741"/>
    <dbReference type="EnsemblBacteria" id="ACU07196">
        <property type="protein sequence ID" value="ACU07196"/>
        <property type="gene ID" value="FIC_00741"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00741"/>
    <dbReference type="HOGENOM" id="CLU_3270397_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="41" mass="4686" checksum="1B963F4D4F0ACB4C" modified="2009-09-22" version="1">MNDAILDESATCGTLKISRDFLNSFPRFITKKNDEAHFILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X467</accession>
    <name>C6X467_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782351.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00750"/>
    <dbReference type="EnsemblBacteria" id="ACU07205">
        <property type="protein sequence ID" value="ACU07205"/>
        <property type="gene ID" value="FIC_00750"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00750"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_10"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="259" mass="28379" checksum="9148965B98103C9A" modified="2009-09-22" version="1">MAKIIGVANQKGGVGKTTTAVNLAAALGVLEKKILLIDADPQANATSGLGIDEANFSTYNLLEHSADARKCVQKTASPNLDIIPSHIDLVAAEIELVDRENREYMLRSALKDIREDYDYIIIDCAPSLGLITINALTAADSVIIPIQCEYFALEGLGKLLNTIKNVQKIHNKDLDIEGLLLTMYDSRLRLSNQVVEEVNSHFPEMVFETIISRNVRLSEAPSFGESILNYDAESKGAIQYLQLAEEVLLKNDHLVSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X469</accession>
    <name>C6X469_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5683 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782353.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00752"/>
    <dbReference type="EnsemblBacteria" id="ACU07207">
        <property type="protein sequence ID" value="ACU07207"/>
        <property type="gene ID" value="FIC_00752"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00752"/>
    <dbReference type="eggNOG" id="ENOG502ZCD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060256_1_1_10"/>
    <dbReference type="OMA" id="KYWKIPI"/>
    <dbReference type="OrthoDB" id="605674at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043738">
        <property type="entry name" value="DUF5683"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18935">
        <property type="entry name" value="DUF5683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970646" description="DUF5683 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5683" evidence="2">
        <location>
            <begin position="63"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="23394" checksum="6E0809B63CBC7A90" modified="2009-09-22" version="1">MSKLTLLFIFLCSAKIFAQVSPKDTIRVENYPTDSVSATKSPSEIEVYADIQELNATAAEMKFNPTKAGLYSAVLPGLGQYYNRKYWKIPIVWGGIGTGIGITLWNQKQYNRYREAFVAELNGQTHEFSDIPGITAEALGRTQDRAKRQRDYAIAVTGLVYILNIVDAVVDAHLYEGRKDPDLALKPTVIYDEFARHNSKAGLSLSYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X483</accession>
    <name>C6X483_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00768"/>
    <dbReference type="EnsemblBacteria" id="ACU07221">
        <property type="protein sequence ID" value="ACU07221"/>
        <property type="gene ID" value="FIC_00768"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00768"/>
    <dbReference type="eggNOG" id="ENOG5033I7E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452437_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973560" evidence="1">
        <location>
            <begin position="34"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="19571" checksum="55BDAF1284B71F0A" modified="2009-09-22" version="1">MAAFFKSIIMKRRIVAAALSLGAFAAGAIQVHAQNSEPISTSVNIILADVIAMDLGSVASESVDFNYTNTADYNSSKNVTVPNSVVIISSKNFDVKVKSEGASFVSGSNAIPVDVLKVKAVSGGTLMGTMNEVTLSTADQVLVSNAALGYKQSLNIAYSISAEKASNVLLGKPKGTYIQKVIYTATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D3</accession>
    <name>C6X4D3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782417.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00818"/>
    <dbReference type="EnsemblBacteria" id="ACU07271">
        <property type="protein sequence ID" value="ACU07271"/>
        <property type="gene ID" value="FIC_00818"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00818"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100971_1_0_10"/>
    <dbReference type="OMA" id="AFGRYYF"/>
    <dbReference type="OrthoDB" id="2018542at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973569" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="198" mass="21327" checksum="BAE589E10CAF6525" modified="2009-09-22" version="1">MKKLMLVGAVALFATANAQESNSTEGFAQGSTFITGAVGYTSESFMDETVSGFTISPSVGYFVSPNIAVGAKLGYTNTKEEEGSFEATSDIFTAGLFGRYYWMPQSKFSIFAELGADYRNITADSNVPNFTEYKANGFGVQLAPGMNYFLNSNFALEAKTGVLGYSSDKPDYDGAEATENFNIGLNLNDITLGLVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H2</accession>
    <name>C6X4H2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00857"/>
    <dbReference type="EnsemblBacteria" id="ACU07310">
        <property type="protein sequence ID" value="ACU07310"/>
        <property type="gene ID" value="FIC_00857"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00857"/>
    <dbReference type="eggNOG" id="ENOG5031NHC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100162_1_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="203" mass="23497" checksum="BDC96AF75753DB51" modified="2009-09-22" version="1">MKTYPKIALFILGAAAMLFVFLLWNAVTKKTEDKVQNDFYIITNQIRKMNKMVVMEQDFSSMQKTRITSELLGGMLPNVEKELITFTKTNAQVSYDLNKMKLEVDSANKKLIIRELPAAEIKIRPSVEIQSMDDSFLDRFDQKDLQKVTKSAKENAYKTVNQQRLRNEGRKQLFDNLDQLFVLARALNYTIEDQTGQIDTTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K9</accession>
    <name>C6X4K9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">FIC_00895</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782493.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00895"/>
    <dbReference type="EnsemblBacteria" id="ACU07347">
        <property type="protein sequence ID" value="ACU07347"/>
        <property type="gene ID" value="FIC_00895"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00895"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_0_2_10"/>
    <dbReference type="OMA" id="YMANLGC"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014143">
        <property type="entry name" value="NHEJ_ligase_prk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02776">
        <property type="entry name" value="NHEJ_ligase_prk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="340"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU07347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="896" mass="102273" checksum="4527048AAD7BBA87" modified="2009-09-22" version="1">MALEQYRNKRSEHKTPEPFGGKPSGKELKFVVQKHHASHLHYDFRLEMDGVLKSWAVPKGPSLDPKVKRLAMMVEDHPYDYRNFEGSIPKGQYGGGTVIVWDEGTYEHDDASESVKKQEKSLLADLKSGKLKFRLNGHKLKGEFALVKAYGRGEDSWLLMKLNDEFATAEDITLMDESVISNKTIDEMAEAPDKIYGQKSEKKKPAISKKATPKKSAKTKNAQIAEVIEEPTADISKILKAAPQQKFYTSVEPMLATLVDQPFDSDEWIYEVKWDGYRAVAFMNEGEVEMKSRNDKSFNEKFYPIYDELKKMNINAILDGEVVVLGTEGKANFGALQNWRSESDGDLVFYVFDLLWYEGKDLKSLPLTTRKQILDEILPKSETVMKSEVFETSGIEFLEAAKKMDLEGIMAKRKDSRYHIKNRTKDWLKIKANKRQEVVIGGYTLNDDSRKLFSSLLVGVYEGTKLVYTGKVGTGFNAKCQREMMDMFAPLVTDKPPFDKEPDVNKPSRFRPDPPHATVTWLKPKLLCEVSFTELTTDGIMRHPSFQGMRTDKSAKTVTLETEQPVAEIVKDDTMIISTRKKADRKTLLNPKDKSQVKKVNGHELKFTNLDKIFWPDEKLTKRDLINYYYQVAPYILPYLKGRPQSMNRYPDGIEGESFYFKDVTGKAPDWAETLGYVSESDGRERRYLVGKDEATLLFMANLGCIEMNPWNSTIKKPDHPTFCIIDLDPDENTFDQVIETAQVTKQLLDSMGAPSYCKTSGSTGLHIYIPLGNKYTYEQSKEFARALVTLVHQELPEITSIERIIKKRKGKMYLDFLQNRPHATIAAAYSVRPKPGATVSMPLHWDEVKKGLKMKDFTMQNALERIKSEGDIFKPVLGKGIDLEKVLRKFEESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N7</accession>
    <name>C6X4N7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782521.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00924"/>
    <dbReference type="EnsemblBacteria" id="ACU07375">
        <property type="protein sequence ID" value="ACU07375"/>
        <property type="gene ID" value="FIC_00924"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00924"/>
    <dbReference type="eggNOG" id="ENOG5032UUH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_566008_0_0_10"/>
    <dbReference type="OMA" id="VEISHYL"/>
    <dbReference type="OrthoDB" id="1585417at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="489" mass="57673" checksum="69474E07E6845DB7" modified="2009-09-22" version="1">MEQTSQSKIGTAEIAVLAILSFILIWFSRDFFFFWDNIVQLAVPANYYYDTNFATLYLPDAITTGHQPFAGLYLALGWKLFGRTVEISHYLILPFVFGVCYQLLHLTGFFLSNVRDRWFAFAAVLGESVMLTQMTVLTFEVFQIFFFLAVINSYLRRNNLGIILFFCGLMLVSLRSTMTGIGFVIFIFLYQIVVTRKFSWREYLVFIPGTILFFAFLLSFYEARGWIVHNTVSKSWENAGRYASPMEMLKNIFLFGWRLFDLGKIIYLLLGVYIISEIYKTKKIDHNFLTLVLIAAGQFIIFFIMTVPYQNYIGHRYLLPITTPLIIAIIYWFLTPGRRNHYFVYYILPYTLLGYIWIYPLRIAKGWDAMPAHWTYYELWRDMQRFTENQKIEPDNIRTFFPNTATLHNITLADDHRRYANNTEKPDYVLFSNVYNESDEVIQKLMQSGKYSAVHTIQKGNVWMILMKKTRLINPNYSKKIKIDTNRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P2</accession>
    <name>C6X4P2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="2">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcm</name>
        <name evidence="3" type="ordered locus">FIC_00929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782526.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00929"/>
    <dbReference type="EnsemblBacteria" id="ACU07380">
        <property type="protein sequence ID" value="ACU07380"/>
        <property type="gene ID" value="FIC_00929"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00929"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_10"/>
    <dbReference type="OMA" id="TISAIHM"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="216" mass="24787" checksum="0977BBA7BEFA281B" modified="2009-09-22" version="1">MQDSFLHKGKRKFLVEYLRDKVGISDEKVLKAINEVPRHLFLESIFEDYAYEDRAFPILAKQTISHPSTVAEQTELLELTEKEKVLEIGTGSGYQTAVLVAMNTWVYTVERQKELHDFAFRKLGELHLRPKFQSFGDGFAGLPTFAPFDKILVTCGAEKLPTELLHQLKIGGKMVIPLGRTDEQILTRFTKRSEKEFEKEEFGAYKFVPMLNSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U6</accession>
    <name>C6X4U6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein containing heat shock protein D naJ N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782580.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00983"/>
    <dbReference type="EnsemblBacteria" id="ACU07434">
        <property type="protein sequence ID" value="ACU07434"/>
        <property type="gene ID" value="FIC_00983"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00983"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276102_0_0_10"/>
    <dbReference type="OMA" id="MKNYYYF"/>
    <dbReference type="OrthoDB" id="1520143at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="216" mass="25172" checksum="84C1F17F014A2E67" modified="2009-09-22" version="1">MKNYYYFLSIAENASEDEIKKAYRKLSIKYHPDKNENDAFFANRFMEIQEAYDILGDKEKRRIYDENLAHQQRSYRPNLPPSIKSFSANKIRVQKGEEVIIKWQTHNADIVKIIPFGLEKGYGERAFKITEFKDGEFQLLLHATNSLLNKTLVRGLTITEVFENDTEKFRSEVEEMFKPQQPSRTNPAGQPKFLRIVLAVLFLVIAVLLLVSAFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X7</accession>
    <name>C6X4X7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">FIC_01015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782611.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01015"/>
    <dbReference type="EnsemblBacteria" id="ACU07465">
        <property type="protein sequence ID" value="ACU07465"/>
        <property type="gene ID" value="FIC_01015"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01015"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_2_1_10"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="142"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="33366" checksum="EA0A101697F4A884" modified="2009-09-22" version="1">MLTTTDLTVEKIHSLLETAEKLATGKKLRAVDDIYVSNLFFEDSTRTKTSFHIAEEKLGLHLVPFDVGASSVNKGESLYDTVKTLKSLGADLLVIRHSKDRFYDELKKIDIPVINAGDGTGNHPSQTLLDLMTIQQEFGKFKGLKIGIVGDVKHSRVAKSNADALRKLGAKVYFSGPEKWFDEGTIINGTYLSIDDLVKEVDVLMLLRIQHERHGEKMKISLQTYHKQFGLTTDREKAMKKDAIIMHPAPINRGVEIADELVECERSRIFKQMENGVFARMAILKDVLEEKGFKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X556</accession>
    <name>C6X556_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805829.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07544">
        <property type="protein sequence ID" value="ACU07544"/>
        <property type="gene ID" value="FIC_01094"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01094"/>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011736_2_1_10"/>
    <dbReference type="OMA" id="YVFRRAI"/>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025364">
        <property type="entry name" value="DUF4268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14088">
        <property type="entry name" value="DUF4268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="10"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="411"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4268" evidence="3">
        <location>
            <begin position="696"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="835" mass="97555" checksum="513A2A6516A1F2EC" modified="2009-09-22" version="1">MKANELQIINFLQAPNVQFVIPVYQRNYDWTNSECRELLNDIISVQEQDRGTHFIGSIVFVHEGTYSTSEVKELVIIDGQQRLTTINILYVALYRFAKENSMADDAERLYNMYLTNQYVKNESSKLKLKQTDANSMAFKAIMMGTESASSTFSNVTENYNYFRSIITENNFDLILGGLNRLIFVEISLERDKDDPQRIFESLNSTGLDLSQSDLIRNFILMDLPPKDQNRIFETIWNPIEENAKDLIKQNSLVSEYIRDYLTLRNKKIPNKNKVYTEFKSLYANKKDEAFQQELENIKSLSVHYKMFINPSTVLDPGIKKELDYINRLEINVAYPFLLQVFEDAENGLLSKEDLIRVLKLIQSYVWRRFIVGLPTNALNKIFMTLYSEVDVEEYYDSVAKALIKKKGSGRFPTDEDAKTALRDKDLYNTQPKNRNYLFEMLENYNNREFVNTNQEQITIEHIFPQHPSDRWNADLTAEEFVAFKEKHLNTIGNLTLSGNNGALGNKSFSEKKEMNVAGSEQGYRYSRLWLNSYLKSIDSWSISNYDERQHMIYERFLKIWEFPAVEIPEAEDAEEQNIFDAESPTHKKLEFFIFQNTRAEMDSVAQMYFYVVRNLYEKNSQLLLGNQELLKITRNAHDFRAPQEVINGWFIESNIDSNSKFSVLKRLLTLFEMEDELYVKYLTGPGVQVEPNRFAIRKKYWQQLLPLISNNGFFTNVNPSKEHSISTGAGIGGLSYTMVVTRSDIRIELTILTASQEKNKMYFNRLLKNKEVIEQAFGKPLAWEESPENKMSRIKYELLEVSIFNESDWGKMNEFFVQNMPKFEQALRPFIKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B4</accession>
    <name>C6X5B4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01152"/>
    <dbReference type="EnsemblBacteria" id="ACU07602">
        <property type="protein sequence ID" value="ACU07602"/>
        <property type="gene ID" value="FIC_01152"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01152"/>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019348_2_1_10"/>
    <dbReference type="OMA" id="YYVKAKN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973714" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="270"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="581" mass="62825" checksum="1D815A9EF17E99B1" modified="2009-09-22" version="1">MIMKLKLSFFLSLCSFVIFAQSAPSYYDGVNFSKTGNALKADLASLITATHTKVISYDELKTLMRTSDADPAVSGNMLMIYGSQASGTHQRSRSANGSWNREHVYAKSKGTPNLGTSGPGADGHHLRPSDVTLNSTRGSLLFDDGTGAMAYKTSRGGWYPGDEWKGDVARILMYMYVRYNVRCLPLNITMNPSTYSQDFPDILLKWNIEDPVSPFEITRNNVVAQTQKNRNPFIDNPYLATVVWGGPAAQNNWPDTFSGGTTGDTEAPSSPLNLTVTDTTSTSISLSWAASSDNVAVSSYQVYADNVLKATVYNTLATVTGLNPATTYNFHVVAKDSSGNVSEKSAAVQGTTKEAPETGTSCGTEDFENMQSVSSSYSEKNWSSNGIIWTATNARNDSQITIDGSKAVCVRKGSLKSSTISGGIGSLTVTTYLPFSDSAGNYLLKINGVMKGQIPYSKTATTTTIQNINVEGTVVIELVDETTNNRVSFDNLSWTCYSVLGNGNVEVKNQKFSVYPNPTTNREIFVSGIGSRETVNVYNMAGQLVQTITNVDNNGKINLTNLQKGVYFITAKNQSAKLIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I5</accession>
    <name>C6X5I5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805958.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07673">
        <property type="protein sequence ID" value="ACU07673"/>
        <property type="gene ID" value="FIC_01225"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01225"/>
    <dbReference type="HOGENOM" id="CLU_1501377_0_0_10"/>
    <dbReference type="OrthoDB" id="2122855at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="179" mass="21345" checksum="8FFEF83FEA92AE9E" modified="2009-09-22" version="1">MKINLIFLSFFTVFYSCKKDSKDDFIEMKKNKNFVLWKNIETITVNDFGHKNTNGNSRPFIKIMTGIDVPKNELLYFVYFDKEKSKLNINQPKDSIDNILLYTNLKMNCYEIVGRKYVQKFEKGENMKIENRDDSKYITNEIVANTELELEKLTSRIWYSNFNKDTISKIKLELEEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R0</accession>
    <name>C6X5R0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806033.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01300"/>
    <dbReference type="EnsemblBacteria" id="ACU07748">
        <property type="protein sequence ID" value="ACU07748"/>
        <property type="gene ID" value="FIC_01300"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01300"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_10"/>
    <dbReference type="OMA" id="CNGGFFA"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="10"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="345" mass="37927" checksum="151AF92A76E5BF51" modified="2009-09-22" version="1">MTNVYDNILGLVGNTPMVKLNTVTRDIPATVYAKLESYNPGHSTKDRIAVHIINAAEKKGLLSPGSTVVETTSGNTGFSIAMVCIIKGYKCILAVSDKTKKEKIAYLKALGATVYICPANVPADDPRSYYEVAKRIAAETPNSIYINQYFNELNIDAHYQTTGPEIWEQTGGKITHLFACTGTGGTLSGSAKFLKEKNPAIKIIGVDASGSILKGFHETGTINTEEIHPYQIEGMGKNLIPGALLFDKVDEFVRVNDEMSAYRTREVALKEAIMGGYTTGAVVQGLLQYSNSHEFSKDDVVVTIFPDHGSRYITKVYSDEWMEQQGFINNGVHNYDLLQKTEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X4</accession>
    <name>C6X5X4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806097.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01364"/>
    <dbReference type="EnsemblBacteria" id="ACU07812">
        <property type="protein sequence ID" value="ACU07812"/>
        <property type="gene ID" value="FIC_01364"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01364"/>
    <dbReference type="eggNOG" id="ENOG502Z838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846963_0_0_10"/>
    <dbReference type="OMA" id="HPIQFEE"/>
    <dbReference type="OrthoDB" id="1522768at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="327" mass="38303" checksum="5DCB6041ED86EB7C" modified="2009-09-22" version="1">MALNLFNPFEDLIFGEQFCFLTGDLTTNTMTVFPTWLMDHFKFGEDRIEMMDKSKTYVYADLHLPCSERVKTAFDELDENIKQAYENGYEGMAALNDQLLFLWTGRMVYGLLYYEMQYESNRALRTGLQFTLSTLLRERFGNFHLMLQSIVESVTFVGRKPWSIAVFPLKYSADIISFRDDSVNLLFQFGVNGFGFIASLQDNGVIGEKQKDILEKMRGYVLHPVQFEELYARFHYSDYILQYKPEYKIENAGNSVTIEALPVEATEDRPLFGFWDDEMFAQLLSNYWQVYGIERGDIIRFQQPFLSFLENPYTKEFILPESISLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y2</accession>
    <name>C6X5Y2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subtilisin-like serine protease</fullName>
            <ecNumber evidence="5">3.4.21.62</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.62" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806105.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01372"/>
    <dbReference type="EnsemblBacteria" id="ACU07820">
        <property type="protein sequence ID" value="ACU07820"/>
        <property type="gene ID" value="FIC_01372"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01372"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_471508_0_0_10"/>
    <dbReference type="OrthoDB" id="305706at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="118"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="534" mass="59486" checksum="BA9429D7DEC4F17B" modified="2009-09-22" version="1">MMEIIDENGKIIPRLITKGNENNPWDAAHDYLDREASAGGRVGYVEPDIKHEIFSAQNPELKQTRTSEYEAFNESEYLKNWPRPDLVEDRFVWHLTDRYSEFKKANKRLLGKIPDPWIKVGHIDTGFQPDHPGLPQNLNKVKSKSFIKGEEGRQAIDIASGTSLEQDGHGTATMIILAGNNVKTSETDDNYEGFVGAAPFAEIISMRISETVALIQTSAFVDALEYAISEGCEVISMSMAGAPTKAWANMVNKAYEAGITIVTAAGNSWFEGPRKALPKTVLYPARWDRVIAATGVAFDNLPYVLKARLQTKSEGGETMQGNFGPADVMEHALAAYTPNVFWATMNDAGKYFRLDGGGTSSATPQVAAAAAIWLTYYRTEINEILKKYPGEKWRKVEMVKSALFGSADRHSYPLHKIYLGRGILKADQALAVAPSGENLKKAKEANVNLWGILDLLGLLLRMKGDDEADKVRGEMFQTEILQQMHSNPALQKFLEYGENEIWTVEDRELMREELLRAPDVSQKLKEYLITDGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X604</accession>
    <name>C6X604_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806127.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01394"/>
    <dbReference type="EnsemblBacteria" id="ACU07842">
        <property type="protein sequence ID" value="ACU07842"/>
        <property type="gene ID" value="FIC_01394"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01394"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_2_1_10"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="OrthoDB" id="1767807at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="203" mass="22468" checksum="2D2CC825BFAF1B4D" modified="2009-09-22" version="1">MIPNFKAHPWHGISAGEEVPAVVNVFVEIVPSDTIKYEVDKQSGYLKVDRPQQFSNIIPALYGFIPRTYCHDEVLNLAIESGATDVTTGDLDPLDICVLSSHNIHSGGMLLEAIPIGGFKMIDKGEADDKIVAVMKGDHAFGHFRDIEELPQAEVKRLMHYFLTYKNLPDEPAKCRIQEVYGAEHAKKVIGASQIDYANKFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X646</accession>
    <name>C6X646_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806169.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01436"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07884">
        <property type="protein sequence ID" value="ACU07884"/>
        <property type="gene ID" value="FIC_01436"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01436"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_10"/>
    <dbReference type="OMA" id="DLVSGWK"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="316" mass="36217" checksum="81286034EED1656C" modified="2009-09-22" version="1">MNLSIIIPLLNEEESLEELFSRIDLVCTSASLSYEVWFVDDGSTDLSWSIIENLRVQHPQIHGIKFSRNYGKSQALHAAFERAEGEVIITMDADLQDFPEEIPELYRMVKEENYDIVSGWKKKRFDNVMTKNLPSKLFNSAARKVSGVELHDFNCGLKAYKKQVVKSIDVYGDMHRYIPVLAANAGFRRITEKEVQHQARPYGTSKFGTERFVRGFLDLITLWFVSRFGGRPMHFFGAVGTLMFIIGFLSAFWLGLSKLIDVSRGIYGHLLTNNAWFFIALTMMILGTLLFIAGFLGEMMIRSNRTHKNYNIDEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X647</accession>
    <name>C6X647_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806170.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01437"/>
    <dbReference type="EnsemblBacteria" id="ACU07885">
        <property type="protein sequence ID" value="ACU07885"/>
        <property type="gene ID" value="FIC_01437"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01437"/>
    <dbReference type="eggNOG" id="ENOG5032XRS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092726_0_0_10"/>
    <dbReference type="OMA" id="YIMISAF"/>
    <dbReference type="OrthoDB" id="1604622at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025250">
        <property type="entry name" value="DUF4199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13858">
        <property type="entry name" value="DUF4199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="192" mass="22330" checksum="187B45C30BAB29DA" modified="2009-09-22" version="1">MVKNVYAVGLMLFAVTMIIFFGMYFFGMNTDYFNNSLLLNAFLLPVVYVAGAYYSVNELKKTGIPMGFRDVFGRAFKPMFLGGLLSVLTMFLFLNIADPDAKDLLNYQYIERQKTELNKEYESAKAVIADEKELAELNTNYKNRLQSFTPEMIKDKDMFSFRQFTYYFAAILVFYVILSTFFASFFRNKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B5</accession>
    <name>C6X6B5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene synthase</fullName>
            <ecNumber evidence="2">2.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806238.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01506"/>
    <dbReference type="EnsemblBacteria" id="ACU07953">
        <property type="protein sequence ID" value="ACU07953"/>
        <property type="gene ID" value="FIC_01506"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01506"/>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_3_0_10"/>
    <dbReference type="OMA" id="KLYCYRV"/>
    <dbReference type="OrthoDB" id="1449625at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="281" mass="32654" checksum="2F406230C1617BF3" modified="2009-09-22" version="1">MNNLEIFDKVCGLSSKMVTERYSTSFARASTLFQPEIRQHIYNIYGFVRFADEIVDTFHGYDKAKLMAEFETSYRVALENGISLNPILHSFCRTQREKNIPQHLVDSFLHSMKMDLADIKDLTDEKYNEYIYGSAEVVGLMCLKVFLNGNVEEYEKLKPYAQSLGAAFQKINFLRDISADFNDLNRTYFPNVDFQKFSIADKKEIEEDIAADFAHAIKGIRMLPISSRIAVFMAYKYYNNLLKKIRKAQPAQLLNQRIRVSNARKVYLFGEMMINKNFNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E3</accession>
    <name>C6X6E3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine cyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01534"/>
    <dbReference type="EnsemblBacteria" id="ACU07981">
        <property type="protein sequence ID" value="ACU07981"/>
        <property type="gene ID" value="FIC_01534"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01534"/>
    <dbReference type="eggNOG" id="COG3823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060272_0_0_10"/>
    <dbReference type="OMA" id="FVTGKNW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017186">
        <property type="term" value="P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="PTHR31270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="349" mass="39014" checksum="3074A7A71A42EE66" modified="2009-09-22" version="1">MSIFEKNLHMTIRTFIALLAFMFVLSCNKDKEILNTLNDYNLSMENKGYHFGDAIELPKDVADNAESITISFGDKETSKLIVDPAFFTLGDNAVTFNIKKKNGEIISQDATINVFAKNPEAELKYDIVKEYPHDSANFVQGFLIEGNTIYESDGQKGSSRIIKYNLGSTTPIAATPQPAEIFSEGAAIIGDKIYQLTWLHKKGFIYNKSDLSLIGEFAYPNVVGEGWGLTYDGKNLILSDGTKNIYFLNPANPSEIVRYISVAGHTEAFDKLNELEYHRGFIYANVWQKPVILKINPANGEVVGKFDFSEIAKLHTTNEDDVLNGIAFKGENMLVTGKNWDKIYEVAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E4</accession>
    <name>C6X6E4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminopeptidase M1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806267.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01535"/>
    <dbReference type="EnsemblBacteria" id="ACU07982">
        <property type="protein sequence ID" value="ACU07982"/>
        <property type="gene ID" value="FIC_01535"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01535"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_1_1_10"/>
    <dbReference type="OMA" id="AASWFPC"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005340938" evidence="1">
        <location>
            <begin position="18"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="3">
        <location>
            <begin position="41"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="315"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="536" mass="61355" checksum="0C88007592E26E3E" modified="2009-09-22" version="1">MKKTLCVLILSSGFAFGQTFTKQDSLKGSNTAFRDFWDVKKYEISVEPNLADQSVSGSNTITFEILKDVTNPVFQIDLQQSMNYKITGSSEKLCTSRRDGDFIFVETIKNYKKGEKHSFTVQFWGNPTIAKNAPWDGGWVFKKDDNGNPFVSVAQEGIGASVWLPIKDIWSDEPDQGIVMKIITPKDLVGVGNGKLLSTTTENNRNIYTWEVKNPINAYSIVPSIGKYVNFKETYDGEKGKLDLDYWVLDYNLDKAQKQFAQVKPMMKAFEYWFGPYPFYEDSYKLVETPYLGMEHQSNVAYGNGYRNGYLGRDLSGTGVGLNWDFIIVHETGHEWFANNITAKDQADMWIHEGFTSYSETLFTENYMDKNSAEKYVQGIRRNIENDIPIIGQYGVRNEGSGDMYYKGANMLHTIRQVINDDEKFRQILRGLGKDFYHQTVTTHQIENYISEKAGIDFSSVFNQYLRTVDIPTLEYSQTGKMLKFRYTNSVENLKLPLRINGNQLISPSTSWQTVQLNDSGSVKLDANYYVNYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G7</accession>
    <name>C6X6G7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoacyl-histidine dipeptidase (Peptidase D)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01558"/>
    <dbReference type="EnsemblBacteria" id="ACU08005">
        <property type="protein sequence ID" value="ACU08005"/>
        <property type="gene ID" value="FIC_01558"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01558"/>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028526_0_0_10"/>
    <dbReference type="OMA" id="DHAGLEC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03890">
        <property type="entry name" value="M20_pepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="PTHR43501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016599">
        <property type="entry name" value="Xaa-His_dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01893">
        <property type="entry name" value="aa-his-dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="482" mass="52557" checksum="3059B6ED1D4BD4DD" modified="2009-09-22" version="1">MKMEITQLEPQVIWKNFAALNAVPRASKKEEQVIEFIKNFGENLGLETVVDAVGNVIIKKPATAGMEDRKSVVLQSHLDMVHQKNNDVNFDFATEGIQMEVDGDWLKAKGTTLGADNGLGVAAIMSVLESSDIPHPALEALFTIDEETGMTGAMGLKPGQLEGQILLNLDTEEDDEIDIGCAGGIDVTASQNYNLEEARGQIVKIEVKGLQGGHSGMDIHKGFGNSNIILGRLLYAGAYTQNIQLIEVDGGSLRNAIPREARAVFSVRNSVEFIEVATELKAVILEEFETIEKDLEITIETFSTSEKAIPEEDSKKIILALKAAHNGVYRMSPDVADLVEASNNVARVELKNGELKILNLSRSSVDSSKFAVAEQLKSVFELAGMNVEFSGSYPGWKPKPGSEIVKLMEKIYENDFGSKPHVVACHAGLECGIIGANYPEMEMVSFGPTIRGAHSPDERANIPSAQKFWGFLKEILKEIPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I7</accession>
    <name>C6X6I7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01578"/>
    <dbReference type="EnsemblBacteria" id="ACU08025">
        <property type="protein sequence ID" value="ACU08025"/>
        <property type="gene ID" value="FIC_01578"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01578"/>
    <dbReference type="HOGENOM" id="CLU_3343947_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="37" mass="4501" checksum="24A4A89743EE6F48" modified="2009-09-22" version="1">MKTLEKTTCFEQEELMKSKLIDEHKMQQNFVDQNIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC4</accession>
    <name>C6WZC4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782105.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00500"/>
    <dbReference type="EnsemblBacteria" id="ACU06958">
        <property type="protein sequence ID" value="ACU06958"/>
        <property type="gene ID" value="FIC_00500"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00500"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_10"/>
    <dbReference type="OMA" id="NIFCKIR"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="156" mass="17903" checksum="9AC918FAC10D184E" modified="2009-09-22" version="1">MNYQLDEIDKKILDFLVENTRMPFTEIAKQMEVSAGTIHVRVKKMEDAGIILGSSLNIDYAKLDYHFTAFIGILLTKSNRTQEVLKELTTIPNVIEASVISGKYNIFCKVRAKNTEDAKRIIYQIDDIQDVMRTESMISMQEYMSDKNRLIDAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD0</accession>
    <name>C6WZD0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, N-terminal section</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00506"/>
    <dbReference type="EnsemblBacteria" id="ACU06964">
        <property type="protein sequence ID" value="ACU06964"/>
        <property type="gene ID" value="FIC_00506"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00506"/>
    <dbReference type="eggNOG" id="COG3959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_4_1_10"/>
    <dbReference type="OMA" id="MVHAVNS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="312" mass="34241" checksum="274F6D8233FFF06F" modified="2009-09-22" version="1">MAFGAFCLKIMLSAPAKNLYFSGQNKSYIMSKSIEELKSLTTQIRRDIIRMVHAVNSGHPGGSLGCTEFFTALYGKVLNYKFPFTMEGRGEDLFFLSNGHISPVFYSTLARFGFFPVEELKTFRKLDSRLQGHPTTHEGLPGVRVASGSLGQGLSVAIGAALAKKMDGDDALVYTLHGDGELQEGQVWEALMFAAHNKVDNLIATIDYNNRQIDGDVDDVLSLGDLHAKLEAFGWKVINEKNGNDLETVIAILERAKAETGNGKPVVIILNTEMGFGIDYMMGSHSWHGKAPNDEQLALGIKQLYLEAPADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF3</accession>
    <name>C6WZF3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00010"/>
    <dbReference type="EnsemblBacteria" id="ACU06488">
        <property type="protein sequence ID" value="ACU06488"/>
        <property type="gene ID" value="FIC_00010"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00010"/>
    <dbReference type="HOGENOM" id="CLU_3270396_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="41" mass="4915" checksum="7E9CF1C3592FC03B" modified="2009-09-22" version="1">MLLKYAFFYADKFTQKEAVNSIIKRLVIPRRLSKNLLFLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI1</accession>
    <name>C6WZI1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00038"/>
    <dbReference type="EnsemblBacteria" id="ACU06516">
        <property type="protein sequence ID" value="ACU06516"/>
        <property type="gene ID" value="FIC_00038"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00038"/>
    <dbReference type="eggNOG" id="ENOG50310QP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1710389_0_0_10"/>
    <dbReference type="OMA" id="TYCKAVY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="20004" checksum="B2D2F3BEA655D119" modified="2009-09-22" version="1">MSGKFVINYLIIFFSKEMKGLLKIYHPEETLKYHIQSTYCKAVYSNKRHFLEVELITDDSVDHVDDDSLQYNFPQLRFTVTEFPIDDAEIEGKTFEIEDSDEEIYTEVDLFDDEDAYLFQNKLTYSNDSEDGLQLCWQGEISDFYTGSDEPIPFKLKCHFKPDVILVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK4</accession>
    <name>C6WZK4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781686.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00063"/>
    <dbReference type="EnsemblBacteria" id="ACU06539">
        <property type="protein sequence ID" value="ACU06539"/>
        <property type="gene ID" value="FIC_00063"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00063"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OMA" id="MIEYPIF"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="238" mass="26553" checksum="332F7683E1CD3501" modified="2009-09-22" version="1">MIKIQNISKVYGTKKVLDIELLEIAKGESFGLVGNNGAGKTTLFSLLLDLIQPSSGFIQIDGEKVNEGENWKTKVAAFIDDSFLIGYLTPEEYFYFLGELRGQTKTMVDEFLKQFDDFFNGEILNAKKYVRDLSKGNQKKVGIVGALIGTPEIIILDEPFANLDPSTQIKLKKLIRTWSQSGEVTFLISSHDLAHTTEVSNRIVVLNKGTLVKDITTNPETLKELEDFFANSVSDVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP2</accession>
    <name>C6WZP2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein 2 (PBP-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781724.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00102"/>
    <dbReference type="EnsemblBacteria" id="ACU06577">
        <property type="protein sequence ID" value="ACU06577"/>
        <property type="gene ID" value="FIC_00102"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00102"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_10"/>
    <dbReference type="OMA" id="SCDTYYY"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="3">
        <location>
            <begin position="48"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="672" mass="75066" checksum="2CE06EBF75A00598" modified="2009-09-22" version="1">MNSHYLKITLILSALALIFIARLAYLQLFTDRYALNAANTSIKTEYIIPQRGVIFDRNGKIMVGNQPSYEISFTEALIRPDFDTIGFCNLMGITKQDFIKRVNVIKNEKYYSKLTPMTFMKNLSREDIARIQEIIFKYPAFSIVSRPQRQYEVSTSGNLLGYTNEVNERDIKKDSLYYLPGDFIGKSGIEKSYEKHLRGEKGVQYIQKDIRLRSIGSYKNGALDKDVVTGKDITLTIDYDLQRMAEEMLVNKQGAIVAIDPTNGEILVLATGPDIDPNLFTGPDKTKNLYRLQMDTIYNNRPTFDRSVQAAYPPGSTFKLLTAAAAMQMGVMDENTIFPCGGGFNYRGLRVKGHGGADPLVPAIQVSSNCYFSYAFIAIMNKYPGNPSKGVDEWKKIMSSFGLGEFLNNDLAVGAKGRIPSGAFYEKRSGGKKDWSSAYTMNGSIFNGMGQGDVLLTPLQMANSVAAIVNKGWYYTPHIVKAIDGKPNPDPRFKVKHKTLVDPKHFGPIMKGMEAVVQAGTARGLKSNEFTMLAKTGTAQVPQGKDNSIFVLAAPADNPKIVIAAVMEHAGFGGTWAGPAATAIAEKYLTGDLKREHLYKKLTDASFMPEYKRQWVVELKRKGLYKEPDKDSMRLENINDSLRFIKNEGIRAKLLLKRDSLQRRLTSKTIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR0</accession>
    <name>C6WZR0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781742.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00120"/>
    <dbReference type="EnsemblBacteria" id="ACU06595">
        <property type="protein sequence ID" value="ACU06595"/>
        <property type="gene ID" value="FIC_00120"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00120"/>
    <dbReference type="eggNOG" id="ENOG50332A7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2303881_0_0_10"/>
    <dbReference type="OMA" id="FAVEQIK"/>
    <dbReference type="OrthoDB" id="2087351at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="105" mass="11981" checksum="DA999B13D8B9C281" modified="2009-09-22" version="1">MKNLHFIGFLLLGLAFLLYYMLPEFSFVKLFEPINLMGILAGIGIGLIIGGIVGYVSKGTALREEQKRQEIKQLRKDKEELERQSAELARQNALRNTPNENPQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR6</accession>
    <name>C6WZR6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">folD</name>
        <name evidence="11" type="ordered locus">FIC_00126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781748.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00126"/>
    <dbReference type="EnsemblBacteria" id="ACU06601">
        <property type="protein sequence ID" value="ACU06601"/>
        <property type="gene ID" value="FIC_00126"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00126"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_0_10"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="9">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="10">
        <location>
            <begin position="123"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU06601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="294" mass="32385" checksum="A3A89D8BFC4B9D49" modified="2009-09-22" version="1">MADILDGLKVSKEIKNEIRTDVEKIVEGKRRPPHLVAILVGQNGASISYVNNKIKDCQEVGFKSSLVKFPSTVSESELLEKINELNLSKEVDGFIVQLPLPAQIDQEKIIMAIDPRKDVDGFHPENFGKMALEMDTFLPATPFGILTLLERYQIDTKGKHCVIIGRSRIVGRPMSILMGRKDFPGNSTVTLTHSYTPHIEEFTKNADIVITALGDPNFLKGDMIKKGAVVIDVGITRIDDDSVKGYRLVGDVDFESCREVAGAITPVPGGVGPMTRAMLLKNTILAYKTSVYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZS3</accession>
    <name>C6WZS3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulphur-binding reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781755.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00133"/>
    <dbReference type="EnsemblBacteria" id="ACU06608">
        <property type="protein sequence ID" value="ACU06608"/>
        <property type="gene ID" value="FIC_00133"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00133"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092359_0_0_10"/>
    <dbReference type="OMA" id="CYLGRAN"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="146"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="260" mass="28874" checksum="B477DC4BE0C97E90" modified="2009-09-22" version="1">MDFTLKTMAEYAAEGKSPEVLFWVGCAGSFDDRAKKITRAFCKILNKINVEFAVLGPEESCTGDPAKRAGNEFVFQMMALTNIEVLNAYDVKKIVTACPHCFNTLKNEYPNLGGNYEVIHHTQFLKQLMEEGRLKIEGGSFKGRKITFHDPCYLGRGNGEYEAPRMLLEKLDAELVEMKRCKTNGLCCGAGGAQMFKEPEKGAKDINVERTEEALSVKPNVIATGCPFCMTMMTDGVKHFDNTTVEVKDIAELLAEADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZX4</accession>
    <name>C6WZX4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781806.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00184"/>
    <dbReference type="EnsemblBacteria" id="ACU06659">
        <property type="protein sequence ID" value="ACU06659"/>
        <property type="gene ID" value="FIC_00184"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00184"/>
    <dbReference type="eggNOG" id="ENOG502ZBDV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004058_0_0_10"/>
    <dbReference type="OMA" id="YWSWHIW"/>
    <dbReference type="OrthoDB" id="16008at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970486" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1036" mass="113972" checksum="A09DE0B84890B23A" modified="2009-09-22" version="1">MTKLHLFAFCLLANAVYSQTANYAKAPNSYIFDLEQAHSQNYGGILIPVKKAYEMWSKYEYLKTDGSSTPIPAGIQSASVYWQDVPRLVKNVNIVPGADASGSSIKVEIDKGRGKGNAVIAFKVDGVIYWSWHVWITDNPANGVAYGHGTETDIDGNPVIIEYMDRNLGAVGSGLVDHQWQKTGGLMYEWGRKDPFPSLVYKDSDFYEITGEVGVMRHPQIDKINTVPVVVRPYSEIEKNIKYSVNNPINYIINTDSGGNWFSSSRYKVAGASPSYVTWDLWSDNAKGGNSNGNSSNTALSRESRSYELKSELDPCPNGWRIPSYYGRETQNNNLSFFGKKADWNNADSNAAQRQLFPDAPNPHLNGVKVYPGIGMDFTQAENGNRNIGQIPLPGAYVYYPNSVSPNAPVGVMFQDNGANGGLWSSTFAYDGARLFSIISDPNRTSTSVGLHAIYNNQTNPTRTGNAVRCIKDPNLAKIGDFATQYFASQKENYTLGLDNPNSYVVVNQEQLEIPVNKAFSVHNQLLSDQEMLPSDKLVASIVWTSNIDLIKNLSINLNSSDPRNSTIAVSLDKNITGNAVVALHNGNKSNPVMWSWHIWATAENPAEYPVTYTTEAPAVVGHHFINPTASKMPPMTTVFMDRNLGALNSNVNTGLANGLHYQWGRKDPIPPLSQVNSNKVFVGVPASPELISTAPIRADTYFKELTETTYDEGFTSPYAVYGSANSDQSRKIRENIKYSVENPLRFMYRNGLGAEFDGGNHYGNDLTKVKDWVSDDRAQAADRWGHADKKSPFDPCPEGWRVPDVSFTNLYTGSKGTSPWYNGYHVDAYGKPGVIQDQWHSITQFYGGEAIGTAGWKFENSTYYHGQIPRDGIRGEVGEFKMKTNRTGLWTASMADLNTGFALAMLIQNDKMQTGTGVYPQAGMSVRCAKDEKRLLGSTAELNKPAAPRPIVVPPKVANAAASETQLSPNPFTDRFSISNAQASTYEIFDFGGKLVQKGIVESGSVSAPQLPTGLYIIKITMKDGSTSTKKIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZX6</accession>
    <name>C6WZX6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781808.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00186"/>
    <dbReference type="EnsemblBacteria" id="ACU06661">
        <property type="protein sequence ID" value="ACU06661"/>
        <property type="gene ID" value="FIC_00186"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00186"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709300_0_0_10"/>
    <dbReference type="OMA" id="RWWIEIP"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="358" mass="41027" checksum="F8F85DE11FD45FDE" modified="2009-09-22" version="1">MNVEDILIPAKAIRSEKWQLGNLISGELQPNGIVLIFCSDYRGINSGSAEIMDYRTVRKELYKLSKLDFEVPVCDLGDLISGKSHQDTHYILQELLLMCHRNNAIPIVVGGSNDLAFSLFSALNLHQKNLTYTQISNVISLINDGGEITEQNFLSKIISGRNFTLKNYHHLGYQKHLNELDSVKLMKEVDFEVIRLAEMMNSTENTEPYFRRADLVTLNCDAVESLGDGFSVNPQVNGLNRREICAYMKETGLSQNLKSAGIFNFNADSDTFFNHQLLAQMIWHLIEGINIQRSHPKERQFEKFWVMIDDAEIAFQRDIFTGLWYFGDDDKAENLIPCSRREYDAAKRGELHRRFSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X026</accession>
    <name>C6X026_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06711">
        <property type="protein sequence ID" value="ACU06711"/>
        <property type="gene ID" value="FIC_00237"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00237"/>
    <dbReference type="eggNOG" id="ENOG5030BB4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130378_0_0_10"/>
    <dbReference type="OMA" id="EEICSND"/>
    <dbReference type="OrthoDB" id="1752932at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="193" mass="22511" checksum="2AA2B9619B89E0E4" modified="2009-09-22" version="1">MQNEVFSLKFKAMKNRKISLESGYWTADGITSPVELIDAFFDFAHLDSYRKVLSEMVSLMYKKEILRKEYPGQLFIFYLAFRSFLRACYRLQSKAHQWKVKADETPPEHSKLCLGSLTGEEYQNPFAVFEKAFTEKTLEEYDFFLCETVHLSLCPCPDASGEDMMTPYLNMTNMLDAAQLMRERGVEKIEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X054</accession>
    <name>C6X054_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase, site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781886.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00266"/>
    <dbReference type="EnsemblBacteria" id="ACU06739">
        <property type="protein sequence ID" value="ACU06739"/>
        <property type="gene ID" value="FIC_00266"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00266"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_10"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="104"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="34355" checksum="66E162B6FE5CCC67" modified="2009-09-22" version="1">MVDRFLEYIAVEKRYSPHTLTSYRRDLEDFSVFLLRTEAHHNYVEVDKKIIRNFMAALGEKAIAKRSINRKLSTLRSFYLFLLKIGEVKTSPLANIQTLKFYAEKQVPFSPDEMNDLQKEEFQPLKTNFLKELIIETLYQTGMRRAELTGLLLDHVDLGKKELKITGKGNKQRIVPVSDDLCAQLEQYLEFRKPLKEYQMYFFVSAKGKKLNDKFVYSAVNTYLSLVTSKKKKSPHILRHSFATHVLEEGAEISKVKLLMGHKSLASTQVYTGTNIEQLKKVFNNAHPRAIQKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X071</accession>
    <name>C6X071_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="9" type="ordered locus">FIC_00289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781903.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00289"/>
    <dbReference type="EnsemblBacteria" id="ACU06756">
        <property type="protein sequence ID" value="ACU06756"/>
        <property type="gene ID" value="FIC_00289"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00289"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_2_10"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="353" mass="38389" checksum="BB7D3FD64AF30A6F" modified="2009-09-22" version="1">MFGLGNFLTLSTFGESHGAAYGGTLSNFPAGLAVDFEAIQKQLDRRKPGQSALVTQRKESDSVKFLSGIFEGKTTGTPIGFIIENENQKSKDYDHIAEAYRPSHADFTYDQKFGIRDYRGGGKSSARETVNWVVAGSLARQILPQNVEIQAYVSSVGEIFCEKPYQALDLSKTDSNEVRCPDEETAEKMISKIKEIKKEGNTIGGTIMCVIKNLPVGIGEPVFGKLQAELAKAMMNINAAKGFEYGSGFCGAKMTGKDHNDLFNEDFSTQTNLSGGIQGGISNGMDIYFRVAFKPVATILRPQQSVDSDGNAVTVEGKGRHDACVLPRAVPIVENLAAFVLADLFLINQMRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C9</accession>
    <name>C6X0C9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781961.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00347"/>
    <dbReference type="EnsemblBacteria" id="ACU06814">
        <property type="protein sequence ID" value="ACU06814"/>
        <property type="gene ID" value="FIC_00347"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00347"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_10"/>
    <dbReference type="OMA" id="ANCIQAG"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="264" mass="28423" checksum="F516F71AC76690F3" modified="2009-09-22" version="1">MTGAKHLEGQWALILGGSSGLGLATAKKLAAEGMNICIIHRDSRQAMAEIQQDFDKIRKKGNPFLSFNVDASNSEKIGSVVNDIRAEVGQGSVYCIVHSIAKGNLKSMVDSQEGELQKNDFLITVDAMSVSLYEWVKSVFSAGLFAKDARVLSFTSMGNSRAYRGYAAVSAAKAALEAITRNIALEFAPYGIRANCIQAGLTDTKSQRMIPGAAEMKEQSIRRNPFKRITTPEDVADAVYLLCQPEAAWITGAVIPVDGGESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D6</accession>
    <name>C6X0D6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide export outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781968.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00354"/>
    <dbReference type="EnsemblBacteria" id="ACU06821">
        <property type="protein sequence ID" value="ACU06821"/>
        <property type="gene ID" value="FIC_00354"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00354"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038343_1_0_10"/>
    <dbReference type="OMA" id="RTATIFK"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="264" mass="29118" checksum="3234B5CB1255A8F3" modified="2009-09-22" version="1">MKIYFPVFIIFTVLLLSACKPKKNIVYLSNNNFEQEISQARYSGLHIQEGDKLQIQVSSFDELAVRPFNRSSMSTTASAADGTSASGSAGGSEYVVSSDGQIIFPVLGVVYCKGMTKQQLKDDLENRLKRYLTDPMVTVTLTNFSIFVLGEVNGPGLKTSPTEKLNIFQAIALAGDLSYDANRTNVKVIRTSETTGKDEVIQLDLSEASVVNSPYYYLQQNDILYVEPDRNKQVSVNNDSAADRWIRYGGVALGLVTLIITLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I9</accession>
    <name>C6X0I9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00408"/>
    <dbReference type="EnsemblBacteria" id="ACU06875">
        <property type="protein sequence ID" value="ACU06875"/>
        <property type="gene ID" value="FIC_00408"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00408"/>
    <dbReference type="eggNOG" id="COG4194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120972_0_0_10"/>
    <dbReference type="OMA" id="PHIFNYP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="156" mass="17375" checksum="97E50513223FFD19" modified="2009-09-22" version="1">MKYVSLILRIISFIILISVWAYTALNFEHLPDQIPVHYDFSGSPDRYGSRHSIWLLLSINTGVFIFLNYLFRNTDSGLLNIPDNIRQNKSLTQLIVSILMILVVTLFAVIAFESIQAGLGKAEGLSSAISYLLGFCLLLVVAILIYSARIGKNHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K6</accession>
    <name>C6X0K6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00430"/>
    <dbReference type="EnsemblBacteria" id="ACU06892">
        <property type="protein sequence ID" value="ACU06892"/>
        <property type="gene ID" value="FIC_00430"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00430"/>
    <dbReference type="eggNOG" id="ENOG5031F58">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060695_0_0_10"/>
    <dbReference type="OMA" id="NAYMENE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973542" evidence="1">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="262" mass="29099" checksum="1ECE5DB8722FF462" modified="2009-09-22" version="1">MKRILSLLVVFSMMNTFAQQISDYSYIFISDQPKDFAGNKFGLQDLLNSKLKAKNYVPICGESSLWPEPAKSNPCSVLQADLHNSSSFLKNKLRIDFTECNQKIIASLEGKSSIKDYEPGFKDALNVALRNLPASNPEKLAVNNVTPKQNVAIAAEPVKSTLSQTQKSNVKTGSKAQTFSNGTLNLNRIHISENQFILASPNNSMPYAIFKESTKKEVYRVQLQDGTQTLGYLENGNIVIEIAAQDGSYKKEVFEETVILAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M6</accession>
    <name>C6X0M6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782059.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00450"/>
    <dbReference type="EnsemblBacteria" id="ACU06912">
        <property type="protein sequence ID" value="ACU06912"/>
        <property type="gene ID" value="FIC_00450"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00450"/>
    <dbReference type="eggNOG" id="ENOG5032SZF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144225_0_0_10"/>
    <dbReference type="OMA" id="FKDTHIQ"/>
    <dbReference type="OrthoDB" id="2028501at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025356">
        <property type="entry name" value="DUF4260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14079">
        <property type="entry name" value="DUF4260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="13106" checksum="746F7950A4AAC33F" modified="2009-09-22" version="1">MKLLLTLESAAFLMIGIFAFTQTGLSWWWFAGLFFAPDVSMLGYLVNNKAGAFAYNLFHHLGVAILVFVAGKYFSVIELELSGIILFSHSAFDRILGYGLKYEDSFHHTHLGRIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N3</accession>
    <name>C6X0N3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06919">
        <property type="protein sequence ID" value="ACU06919"/>
        <property type="gene ID" value="FIC_00457"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00457"/>
    <dbReference type="HOGENOM" id="CLU_3389556_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="32" mass="3867" checksum="0B8FBE939CC2E0A7" modified="2009-09-22" version="1">MGYFISNKEEILFWFSLDILLAMPKSMKLLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0R5</accession>
    <name>C6X0R5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781977.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00363"/>
    <dbReference type="EnsemblBacteria" id="ACU06830">
        <property type="protein sequence ID" value="ACU06830"/>
        <property type="gene ID" value="FIC_00363"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00363"/>
    <dbReference type="eggNOG" id="COG1519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745266_0_0_10"/>
    <dbReference type="OMA" id="WIARDNI"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="345" mass="40241" checksum="CE63FE24906B45B3" modified="2009-09-22" version="1">MKILFAYNITDQDNDFVSIHIEILHQLGYDVTASLDEFWQPTKSYGLVVINWPEVFFGWKMNITDDEVAKLNSALLRWNAIETQLLTFFHDEYSHFGRSANLNLLFDLCYRRSDFLIHLGGYSKNKYTALYTDAQHYIIYHPLYTDFQTDRDKNISRQKLGVSQDTYLVFVPGGIRKTEEIDYCLEVYRRLPVKNRQLIFQKTNFLARPRALKNFTDLKVWVYYLLHTKRFKLRENISFLQGFMDKDLLAAYFAASDVVIIPRTDILNSGNILLAAQFGKPMIGSGSGNMGELLRLLGQQCLPPNFMHDQNITIPENNPVEIKQAVVRYANNEVIKKQWQQILKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S5</accession>
    <name>C6X0S5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">FIC_01592</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806323.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01592"/>
    <dbReference type="EnsemblBacteria" id="ACU08038">
        <property type="protein sequence ID" value="ACU08038"/>
        <property type="gene ID" value="FIC_01592"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01592"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_10"/>
    <dbReference type="OMA" id="HMVGDRM"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="4"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="347"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU08038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="467" mass="50003" checksum="CF9A812344BC9960" modified="2009-09-22" version="1">MSQFDVTVIGSGPGGYVAAIRCAQLGFKTAIIEKYPTMGGTCLNVGCIPSKALLDSSEHFENAKHTFANHGIIIDEPKADLARMIARKNEVVEQTTKGIQFLMDKNKITVFEGVGSFESATQIKVTKNDGATEIIDSKYTIIATGSKPSSLPFISLDKERVITSTEALELKEIPKHLVVIGGGVIGLELGSVYKRLGSEVTVVEFMDKIIPTMDGALSKELNKVLRKQGIKFMLSTAVQAVERNGDAVKVTAKDKKGEEVVVEGDYVLVSVGRKPYTDGLALEKAGVDLDERGRVKTNGHLQTNVSNIYAIGDVVAGAMLAHKASEEGVLVAEQLAGQKPHINYNLIPGVVYTWPEVAAVGKTEEQLKEEGVAIKVGNFPMRALGRSRASGDIDGFVKIIADEKTDEVLGVHMIGARAADMIAAAVTAMEFRASAEDIARMSHAHPTFAEAIKEAALDATAKIAIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0T0</accession>
    <name>C6X0T0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01597"/>
    <dbReference type="EnsemblBacteria" id="ACU08043">
        <property type="protein sequence ID" value="ACU08043"/>
        <property type="gene ID" value="FIC_01597"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01597"/>
    <dbReference type="HOGENOM" id="CLU_3135932_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="49" mass="5521" checksum="320B29104FEDAB37" modified="2009-09-22" version="1">MMLFNKALIIQIERAGKFPALLGWVFVILRKNDSIFSPDCSGILLRNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0T2</accession>
    <name>C6X0T2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806330.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01599"/>
    <dbReference type="EnsemblBacteria" id="ACU08045">
        <property type="protein sequence ID" value="ACU08045"/>
        <property type="gene ID" value="FIC_01599"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01599"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_2_0_10"/>
    <dbReference type="OMA" id="HYQYSFQ"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973554" evidence="1">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="68"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="332" mass="37951" checksum="39F672258A15D77F" modified="2009-09-22" version="1">MKLKSLSLILFLMLATLGAQDLTKLQPLDAELTTVQYPFPVQFKKLTTQGQALKMAFMDVKPAKANGNTIVLLHGKNFNGYYFEQTAKVLQAEGFRVVIPDQVGFGKSSKPKQYQFSFEQLAENTKLILDDLKIDRFIIMGHSMGGMLATKMAVMYPQNVEKLILTNPIGLEDYRNFSPYQNIDKLYTSELKNTYSSYRDYQLKFYYDGKWKPEYDKWLNLLAGWTVHKDFPITAWNAALTSDMIYTQPVVDDFQNIKVPTLLIIGTRDRTAIGKANAPKELQPLMGLYQNLGKETHRKIKGSKLVELENVGHSPHIEVFDRFIDPLLAFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0V3</accession>
    <name>C6X0V3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01621"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="ACU08066">
        <property type="protein sequence ID" value="ACU08066"/>
        <property type="gene ID" value="FIC_01621"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01621"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007893_0_0_10"/>
    <dbReference type="OMA" id="SVDYLEM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="219"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="320" mass="35010" checksum="015B2EB279270F64" modified="2009-09-22" version="1">MNCLKFCNFATLNLNIMAFKNRMKNMITGKRKINLIMAVLLMVVFGQALFIGKLYSERDNKSYEVNLVKINTQRDSVDYLEMKNNLALVDHTVRELNDFLASKNLTDAKISTLAQDSISNAVYLAKQTNRYSQYLMDLQTKLQQVPLGVPTDGYISSNFGKRVNPIPPPNVMFASATPISKTTLAAKAVEKDSLGIVISSPVKNNSPEKTSAEKKPVIQFHKGMDFAVAYGTDVRAAAKGKVIFAGAKGGYGNCVIVAHGNGLATLYGHLSTISVKANDVINVNQVIAKSGNSGRSTGPHLHYEVHKNNTPVNPKLFLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X100</accession>
    <name>C6X100_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806398.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01669"/>
    <dbReference type="EnsemblBacteria" id="ACU08113">
        <property type="protein sequence ID" value="ACU08113"/>
        <property type="gene ID" value="FIC_01669"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01669"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085957_4_1_10"/>
    <dbReference type="OMA" id="MLVNKRE"/>
    <dbReference type="OrthoDB" id="1683794at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="164" mass="17682" checksum="894AD5182A505B96" modified="2009-09-22" version="1">MEQVIFFSVAAIALASAVYFVIARNPLYAILALIVTFFSIAAMYILLNAQFLGIVQIIVYAGAIMVLFLYILMMLNLNRADESKKQNLTKFIGVFAACILFIGLLGAYKGLGTGTYGTGVDSSIGLTKNLGRLLFNEYVLPFELASILILAGIVGAVLIGKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X116</accession>
    <name>C6X116_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/iodide co-transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806414.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01686"/>
    <dbReference type="EnsemblBacteria" id="ACU08129">
        <property type="protein sequence ID" value="ACU08129"/>
        <property type="gene ID" value="FIC_01686"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01686"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_11_4_10"/>
    <dbReference type="OMA" id="VIQTLIM"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="526" mass="58304" checksum="2802D8B246BA88DE" modified="2009-09-22" version="1">MNPSTILLLFVFAYFIGLLVISYITSRNADNQSFFIGNKKSKWWLVAFGMIGTSLSGVTFISVPGTVGKITAGDYPFGGFEYYMLVIGFFIGYFIVAAVLLPLYYRMNLTSIYTYLGRRFNVEAHKIGSLFFIISRSIGATARLFLVVNVLQIFLLEDLGVPFWVTSAVILLMVLLYTFEGGVKTIVVTDTLQTSFMILSLVACIIFILSNLNLSAGEAYDVLAAKDYTHFINYDVNSKTFFLKTILGGMFITIAMTGLDQEMMQKNISVDSLKNSKKNMLTFAGTLLIVNLAFLFLGGLLYLFAMENGAVYGQVVDVVNGTETVSNAFGFKDAANGTITNVMGDDLFPALSLQGYFPLFIAVIFIIGLISALFPSADGALTAVTSSYCVDLLNINDDTTKTEKQKKRLRMKIHLIFTVVFFALIMIFKAINDKSIVYLIMEVAGYTYGPLLGLFAFGILTKFQITKKYAIIAVTLLAPVLTYLINYVVTQQTDYRIGVELIIINGLLTFFGLWLIRNKQMPQAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X119</accession>
    <name>C6X119_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806417.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01689"/>
    <dbReference type="EnsemblBacteria" id="ACU08132">
        <property type="protein sequence ID" value="ACU08132"/>
        <property type="gene ID" value="FIC_01689"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01689"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_1_1_10"/>
    <dbReference type="OMA" id="HMGLQTV"/>
    <dbReference type="OrthoDB" id="833478at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="178"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="301" mass="33596" checksum="CADA210F28B0E11A" modified="2009-09-22" version="1">MSNIGLIIEEKAADIGNFLVGRLLPFRGKRAVGPFVFIDHMGPAALKDYQNLDVPPHPHIGLSTLTYLLEGSIQHKDSRGSDIEIKPGAVNWMTAGKGVVHSERTPEYLRYTDKKLHGFQIWVGLPKELEQSEPSFHHTEASEIPKWEADGLHYKLIAGDLFGRKSSVPVHSKLFFLEIKSKAAQKVNIGGHLFGEVAMYVLDGSVQIEGNTFSGKQLLVAKNAGLCEFGMSENSTVFLFGGEPFAEERYIFWNFVNSEKDVIETAKKNWHQQNHEAFPLVPGDIEEYVPLPEALLKSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X156</accession>
    <name>C6X156_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative mannosyltransferase involved in polysaccharide biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806454.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01726"/>
    <dbReference type="CAZy" id="GT32">
        <property type="family name" value="Glycosyltransferase Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08169">
        <property type="protein sequence ID" value="ACU08169"/>
        <property type="gene ID" value="FIC_01726"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01726"/>
    <dbReference type="eggNOG" id="COG3774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073547_2_0_10"/>
    <dbReference type="OMA" id="NFDMHEN"/>
    <dbReference type="OrthoDB" id="797299at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="256" mass="30102" checksum="DC20F1CE566F66E4" modified="2009-09-22" version="1">MIPKKIHYCWFGGQPKHELAEHCIASWKRIHPDFEIIEWNESNSPVDDNSYVKEAFAQGKWAFTSDYVRSKVMYEHGGIYMDTDMELKLPLDEFLNEKAVCGFEVKGVPYSAFWMAEPKHQLSKDFMDWYNRQEGFFERINTDVFSEMLEKEYGANRYSDTIQELKHGVKLYPSVYFSQDLPKNYVSHHFNGSWFGGDSENTHKKMVNVYGLLERLVNYPDAAKSVESIINEHKIIDVNAVLDLIPKERIREYLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X158</accession>
    <name>C6X158_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01728"/>
    <dbReference type="EnsemblBacteria" id="ACU08171">
        <property type="protein sequence ID" value="ACU08171"/>
        <property type="gene ID" value="FIC_01728"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01728"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793605_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="144" mass="17044" checksum="460A1DA10DAF55B6" modified="2009-09-22" version="1">MPNHFHLLVRIKPDLVLEEVVKGQNGSSTEIKGLHSSQHIFSKQFSRIFNSYSQAFNKENDRHGSLIESPFKRKLITSEEYLRQCIIYIHQNPISEDFTKYPYSSYTTMLSKSPTSLKRDEVIEQFEDIENFIFCHKKENTYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X161</accession>
    <name>C6X161_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucuronidase</fullName>
            <ecNumber evidence="6">3.2.1.139</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01731"/>
    <dbReference type="CAZy" id="GH67">
        <property type="family name" value="Glycoside Hydrolase Family 67"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08174">
        <property type="protein sequence ID" value="ACU08174"/>
        <property type="gene ID" value="FIC_01731"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01731"/>
    <dbReference type="eggNOG" id="COG3661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007125_1_0_10"/>
    <dbReference type="OMA" id="DNNGWGQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Glyco_hydro_67M" evidence="5">
        <location>
            <begin position="116"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67C" evidence="4">
        <location>
            <begin position="434"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="681" mass="77602" checksum="BBB2E7B3130EDF3C" modified="2009-09-22" version="1">MTQTNSRYGFLFVLFLLPFIAMAEDGSKLWLRFPNVKNGVSAQKITAKGNSKTLGIAKKELTSFWQGRAVELRIDKSLSKLKDGYTIKSNASKITISSAKESGLLYGVYHILRLQETKENLTNLNISEKPSYDIRILNHWDNLDRTVERGYAGYSLWKWDELPQTISPRYEEYARANASIGINAVVLNNVNASPNVLKTEYLQKVKALADIFRPYGIKVYLSVNFSSPKVIGGVENSDPLNNDVRNWWKNKASEIYKTIPDFGGFLVKANSEGQPGPQDYGRTHADGANMMADVLKPHGGIVMWRAFVYNPTPEDRAKQAYTEFVPLDGKFSDNVIIQIKNGPVDFQPREPFSPLFGALKKTPEMVEFQITQEYLGFSNHLVYLAPLFKESLDSDTYSDGPGSTVAKITDGTLRPAKLTAISAVANIGEDTNWTGHHFAQANWYAFGRLAWNHQLSSEQIADEWLKMTFTDNAAFINPVKDMMLSSRETATDYMMPLGLHHIFASGHHYGPEPWGDYPGARPDWTPVYYHKADASGIGFNRTSTGSNAAAQYNSPLKEQFNNIAETPENLILWFHHVPWDYKMKDGKTLWENLAYRYDLGVQQVREYQKTWDRMQPYVDAERFSHIQSRLKIQAKDAVWWKDACLLYFQTFSKKPIPYDIERPVHELEDLKKIKLDIKHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X178</accession>
    <name>C6X178_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01748"/>
    <dbReference type="EnsemblBacteria" id="ACU08191">
        <property type="protein sequence ID" value="ACU08191"/>
        <property type="gene ID" value="FIC_01748"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01748"/>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038944_8_0_10"/>
    <dbReference type="OMA" id="FVFPYDP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="245" mass="27479" checksum="9C89675DFC521978" modified="2009-09-22" version="1">MPNIRFMTEKSTKNSTPKSKLPLYMSLLLIAALAVSYFTVPDVKEFFTEAWQVLTSDNETRIRNWVGQYGWWGPVIIIVAMTAQMFLLVIPTILLMIVAVLAFGPVWGSVISYFAVFIASTVGYWVGNYFGTGLITGLLGEKTFKKVETFLKEYGFWAIAVTRINPFLSNDAISFVAGILKMKYLKFIYATLLGISPLILLIAIMGDNTHSLKTGLLWGSIVSLVLFIAYVIWDRNRKSRNASTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X181</accession>
    <name>C6X181_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase/carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806479.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01751"/>
    <dbReference type="EnsemblBacteria" id="ACU08194">
        <property type="protein sequence ID" value="ACU08194"/>
        <property type="gene ID" value="FIC_01751"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01751"/>
    <dbReference type="eggNOG" id="COG0400">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_5_3_10"/>
    <dbReference type="OMA" id="GRQWYGL"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="212" mass="24366" checksum="1171C6E443242E0D" modified="2009-09-22" version="1">MDLKYLVREPANITPATPLLILLHGYGSNEEDLFSFTPTLPEDWLIVSFRAPLSSQYNGYSWYDIDLMNVENRVDVPQAKDSVNLILENIMSVSNRYGLTENETHLIGFSQGGILAYALALQNPELFNKVACLSAYPEEKIMENIVKDKKKLERLRFFISHGTDDATIPLEWGRKAADLLYDLSCYFSFREYMSGHGVNQKNYMDLMDFLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A4</accession>
    <name>C6X1A4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YaiO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01774"/>
    <dbReference type="EnsemblBacteria" id="ACU08217">
        <property type="protein sequence ID" value="ACU08217"/>
        <property type="gene ID" value="FIC_01774"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01774"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053131_0_0_10"/>
    <dbReference type="OMA" id="SLEYWND"/>
    <dbReference type="OrthoDB" id="1313621at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030887">
        <property type="entry name" value="OMP_YaiO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19413">
        <property type="entry name" value="YaiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04390">
        <property type="entry name" value="OMP_YaiO_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YaiO" evidence="1">
        <location>
            <begin position="188"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="422" mass="48376" checksum="F728E697DB97B6D7" modified="2009-09-22" version="1">MQITPILRSNSLRQFLYTLLFVFVPLLSFAQEEKTADDLFTQARTVAFDQKDYPAAISLAKQALEKAPDYTDISVFLGRLYTWNKIVDEARAVFQDLEQKQVQDEDFYLAYASLEYWNDEEMKALEIADKGLTQNPRSEALWLLKAKILNSTDEYLAAEDAVTQLLRINPSNTEARGLLVRLNELTSKNAVGITYGYTHFDKQFADDWHLFGVSYKRVTPIGSIILKGNIASKFGDTGTQIELEAYPRLSDIFYLYVGGAYSNDVGIFPNYRTGVSLNANLPKSFEAEIGYRQLYFSDNIWLYTAAVGKYYKNFWFNLRTYITPDNSNISHSYTGTVRYYTKGAQDYFSIQAGTGISPEDNRSNLLDNETYKLKTFKVGADYNFSVKNKNLFSVGAMYFNQEYRPGTRGNQFDLTFGYTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B2</accession>
    <name>C6X1B2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component system sensor histidine kinase</fullName>
            <ecNumber evidence="4">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806510.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01782"/>
    <dbReference type="EnsemblBacteria" id="ACU08225">
        <property type="protein sequence ID" value="ACU08225"/>
        <property type="gene ID" value="FIC_01782"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01782"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_10"/>
    <dbReference type="OMA" id="WDRGKGI"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="125"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="344" mass="39090" checksum="0984F72E045B1B5E" modified="2009-09-22" version="1">MQVQKLTLVASVFLTIAMSLVALLFNYTNDDAFHNINSFYLTLVLCVLLIFGLNYIILDYLFNIYGKEQIKKISTILPEYIDDGEEGDLNLNNLGQRFSEISRKNATEIGSMKHMETYRKEYLGNVSHELKTPLFSIQGYVETLIDGGVENLAIRDKYLERIDKSVERLLNIVKDLDMINQYESGEITLNISRFDINLLIREIIDLLDLEAERKGATVILQPSAAQIFVLADKQRISQVLINLIANAVHYANREKAQVTVRTTVLKNKVLVVVEDNGMGIKPEVLPRIFERFYRVETSRNRSDGGSGLGLAIVKHIMEAHGENITVESVYLEGTKFSFFLEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G6</accession>
    <name>C6X1G6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01836"/>
    <dbReference type="EnsemblBacteria" id="ACU08279">
        <property type="protein sequence ID" value="ACU08279"/>
        <property type="gene ID" value="FIC_01836"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01836"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018339_0_0_10"/>
    <dbReference type="OMA" id="MDYGPAP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011408">
        <property type="entry name" value="Aldehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699:SF211">
        <property type="entry name" value="PTHR11699:SF211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036490">
        <property type="entry name" value="Aldedh_dupl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="65"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="568"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="821" mass="91018" checksum="1037B6FC12E426C0" modified="2009-09-22" version="1">MRQWKKKYSSTIIKYNHHSSSKNVMEIKEIYETMVYGPAPETAKPAIEFLEAHKRSFGLFIDGKWVKPNSEKYADTHNPSTKEFLAKIAEADETDVNNAVQAANKALPEWVAIGGFERAKYLYAIARQIQKHSRLFAVLETLDNGKPIRETRDLDIPIATRHFYHHAGWAKLMDTEFRDYKEVGVIAQIIPWNFPLMMLSWKIAPALAMGNTVVLKPAELTSLTSLLFAEICDKVGLPKGVVNIVTGRGSVAGSSLVGHPDVHKVAFTGSTDVGKVLRRQIAGSGKKISLELGGKSPFIVFEDADLDSAVEGIVDAIWFNQGQVCCAGSRLLIQESVSEKFYQKLRARMDTLRIGDPLDKTVDMGAIVSKEQFKTIDDMVKLGVKEGCTLYQSKNAVPKQGYFYPPTLFTDVATSSVIAQVEIFGPVLVAMTFRSHTEALPLANNSRYGLAASIWTENINLALDIAPKVKVGSVWINCTNQFDAAAGFGGYRESGFGREGGREGLYEYMKPRVEDDFAEQPSVPKTEKSSAPRKNLNSLADIDRTTKMYIGGKQARPDGGYSTEIKNSFGEYIGEVSEGNRKDIRNAVEAAHAEKSWAGMTGHARAQVLYYIAENLAIRADEFAERIVQMTDQSLDSAKDEVEKSIERIYTYAAYADKYDGAAHSTVQRMVTLAMPEPIGVMAVICPEENPLLGFISTVIPAIAMGNKVVVVPSEKHPFSATDFYQILETSDVPGGTVNIVTGPKDELAKELAKHYNVEGIWFFGSREGSREIEMLATDSMKRSWVNFGKYRNWLDTSHGEGQEFLRHATEIKNIWIPYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H3</accession>
    <name>C6X1H3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01843"/>
    <dbReference type="EnsemblBacteria" id="ACU08286">
        <property type="protein sequence ID" value="ACU08286"/>
        <property type="gene ID" value="FIC_01843"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01843"/>
    <dbReference type="eggNOG" id="ENOG5033G3T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168294_0_0_10"/>
    <dbReference type="OMA" id="SDNTQKV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973589" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="128" mass="14528" checksum="5D24B553DB8721A3" modified="2009-09-22" version="1">MRIFKNIKFYTVKKLLFFIMLIGSLTAFSEVSAQSVNREPFAASQKSDDGVIVAYPNPARDFIVVKSKDSSVKIKSVTFYSILGVQVAEYAVNMNSGEIRLDRLRPGKYLMRYTMSDNTQKVTQIVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I6</accession>
    <name>C6X1I6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01856"/>
    <dbReference type="EnsemblBacteria" id="ACU08299">
        <property type="protein sequence ID" value="ACU08299"/>
        <property type="gene ID" value="FIC_01856"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01856"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470714_0_0_10"/>
    <dbReference type="OMA" id="AWEENFN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025738">
        <property type="entry name" value="BatD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40940">
        <property type="entry name" value="PTHR40940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13584">
        <property type="entry name" value="BatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973476" evidence="2">
        <location>
            <begin position="21"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="579" mass="65836" checksum="E51C6629AC13F417" modified="2009-09-22" version="1">MVMKNKFYYILFLFSALSVAGQVTLEVSEVKDTKVNQKFNLTVLLEISGENMVQETPLRMPDMSKFDIVGSASEQNTVVLDPKKGDVLNQLIYQYVLSPKQSGKIKFGSVLVTVNGKIYKTEPFEINVRDSEKASAPNDYAINDDVYLNMEVQDRSIYKHQPTVAILRAYSRNYGSLRKVQDIRYPKQKNIRIEPVHFAKAEIETRSGLASQVLAVFLIFPSESGSIDISPVSASLSNARSEKLSSNKVRLHVKKLPAGMPAFYKNAVGNFDISVAKRDPAEKTEIDKPLNVTVKVSGSGNFKSLNLPKMVPSENYTFFKPKVTPNTNPDKEGLEGSITADYVVIPKKAGPVTIQFEQFSYFNPTEQKYVDLGMQELLIDVQTHEQIVDAKSALERVNDYTNNVLETVNTPVLQTQHLKIKNKEVINWKIVFGNLALLGVLISAFFVARKKIDRHRAKPVAVGKPIVTIAETEEILRKKMSVQFDDNIEYLKNRFKNKDFTKFFTAYDELHAETKKSLKVANDTDFRKYLEQHFGQIVAEDYRILSEQIKIEKYAPYHSEETMEKLLRSIIKLYSEIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K8</accession>
    <name>C6X1K8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pectinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806606.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01878"/>
    <dbReference type="EnsemblBacteria" id="ACU08321">
        <property type="protein sequence ID" value="ACU08321"/>
        <property type="gene ID" value="FIC_01878"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01878"/>
    <dbReference type="eggNOG" id="COG4677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287395_0_0_10"/>
    <dbReference type="OMA" id="SITETME"/>
    <dbReference type="OrthoDB" id="67852at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973595" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase" evidence="4">
        <location>
            <begin position="767"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1072" mass="114398" checksum="E9817CFB18097BD3" modified="2009-09-22" version="1">MKKNLLLIYLLIPVMSLFGQLTDVWDFGAQQLDPAQYNNKLTVSVINSWYNPAITPGTASTSNVFPSTFTAGELSWTGGNNDRLRTTNPALTRYDENIASVTSYTGRLYCNAIPTVTAGLPNARYFRMTLNADDEVKVISRGDTAGNLTFSFASDAAVQNDKFPTTTTSGAVTEATFVAKQTGTYFIYDAVAKGSFYRIYRKAAVYTSVSGTVDVSQAAGIPAGYSLVFTNAAGKSWSVPVSTNAYQVNLPVGFDYSVSLADASGFIVTSGENFSTVGASNILTHNISVASVSLYTVTGNITGLASQISNLTLTFTPDPASESIYVPSPVVNSAASTYSVQLAPNIQYAVSASGVNDYEITNNTLTITGDTTYNLNFAEKPKYAVNLDVSGLSTAQQAALNVTLTNLNEPGYVYSFSDLQNITLRNGVYKISVSGLDNFPVEMSLTSNLTVNGAAVNKSISFKPVTVWSFDDQQINTSTSAYYKGMQLNGQVTTVPASGHLTAKPGATLLVPVNPGEKVVVSYYYSANFSVEGGATFSTASNSTSITETMEYAYTGASAGNVTVAMGGAAGSTSYFTEIRTIPNVPYAAELTVGPGKQYASVNAALTAVSNMTRTEGQRVTISIDPGNYEEMLVISQPNVTLKNASSAPGTDILNQGTEISPNAVRITSYYGHGYNYYSMGANQKWNEEVLNVNKENGAYSYTNTGAGTTNGSFWNATVVLNAKGFEAENIIFENSFNQYISTKETQDVVVPWASGSPGARPSNLNNTSVQNKTLVERAAALAITASGDRAFLKNCRIIGRQDTFYGAQGARVAVYRGDVMGAVDFIFGGMTAVFYETKLVMNTSDQSSDLSYIVAPQQTSGRGFLMYNTTITSAQPITQTASAYRSKPGYFGRPWSANTSEAVFYNTTIETSDFPGFVGQSLVLPLGWQNSLGGTSPGMYEYGTTELSGVNNSGSRATWATSLSQPVLTDGTSITTLNFTKGNDGWDPFNDITLSTGVVKTDNGTAVYAVKNEVFVKAVKSETAVKVYTMSGLLYKTLNTSKDTNFTLPAGIWLVTVQNNKGTKSVKLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L6</accession>
    <name>C6X1L6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-Hydroxy-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.14</ecNumber>
            <ecNumber evidence="2">4.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="2"/>
    <dbReference type="EC" id="4.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806614.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01886"/>
    <dbReference type="EnsemblBacteria" id="ACU08329">
        <property type="protein sequence ID" value="ACU08329"/>
        <property type="gene ID" value="FIC_01886"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01886"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_0_10"/>
    <dbReference type="OMA" id="MPGAMTI"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="24322" checksum="E12DB60F648C1E8D" modified="2009-09-22" version="1">MSNIQKVSDAIVKQGILPLYFNADETITIETLRAIYRAGIRAVEYTNRGEAALNNFRKMVETRDAEMTDLLLGIGTIKNLQQARDFVDAGADFFISPGFVPEVADFLISQDKFYSPGCMTPTEIIAAENAGVKFIKLFPGNMLGPDFLSGIKDIFPNLLFMPTGGVDTTRQNIEGWFKAGVSAVGMGSKLISKKLMADKAYDQMEDETRKVLEIVSSVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M9</accession>
    <name>C6X1M9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative disulphide-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01900"/>
    <dbReference type="EnsemblBacteria" id="ACU08342">
        <property type="protein sequence ID" value="ACU08342"/>
        <property type="gene ID" value="FIC_01900"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01900"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032298_1_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973597" evidence="1">
        <location>
            <begin position="26"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="397" mass="45101" checksum="CCD9DC329F00ACC6" modified="2009-09-22" version="1">MQKFQVFMKKILLLILFSISTPFLAQQSINFETGTFQEILAKAKSQKKLVFMDAFAVWCGPCKMMEKNIFPLPAVREYYNANFINARIDMEKGEGIGIAQRYGIRSYPSYLILNGDGEVVKQTYGYMGEEPFLAFAKQANDPKFATSSNKELFEKGESAPEFLLNMMQLYSQTDFDVAQKASERYFQVKKDQALTKDEVGLLLYFTKSPVDVNYKTFVSRKPEIITLMSEDIYNQFDTNIKISSILENAMDKKTGRINDGQYYKDAIPLVGAAEAEIALHRTKVIVYPNAGLFDEYEKAALSYYKNSENFSQDELLKAAWIFSDHVTNISSLKKAQEWAEKSVMQAETPENTYILARLYAKTGQKENAKMYAESSKNLAERLGKDATAAIQLLGTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1N4</accession>
    <name>C6X1N4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01905"/>
    <dbReference type="EnsemblBacteria" id="ACU08347">
        <property type="protein sequence ID" value="ACU08347"/>
        <property type="gene ID" value="FIC_01905"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01905"/>
    <dbReference type="eggNOG" id="COG4152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OMA" id="TTMRMIC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="303" mass="34551" checksum="AA001FAAABF1E42D" modified="2009-09-22" version="1">MMLKAENVTKTYNAGKKLALENFSIDVPEASIYGLLGPNGAGKTTFIRIINQITQADSGNVFINNQKLNPEHIRQIGYMPEERGLYKNMSVGDQLLYFGELKGMSKNDALSEAKYWFEQLQIDQWWKKKLSELSKGMAQKIQFVVTVLHRPKLLILDEPFSGFDPVNANLIKDQILNLKKNGTTIILSTHRMESVEEMCDYVALIDHAKKVLDGKVFDVREKFKKNIFGVTLSDVDSEQFESFKNRFAIENYSGENQLISFDLKNDSDQNLMLNELMKVGKIRSFDEKIPSMNEVFINAVAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R8</accession>
    <name>C6X1R8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806666.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01939"/>
    <dbReference type="EnsemblBacteria" id="ACU08381">
        <property type="protein sequence ID" value="ACU08381"/>
        <property type="gene ID" value="FIC_01939"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01939"/>
    <dbReference type="eggNOG" id="ENOG5032NEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784705_0_0_10"/>
    <dbReference type="OMA" id="YYLYYNT"/>
    <dbReference type="OrthoDB" id="1499314at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="353" mass="42059" checksum="12E2B0E9E93C8059" modified="2009-09-22" version="1">MSYYLLFIFASFISLFENRRKLLSVVLIVVLALFAGSRYYIDSDYSLYYNYFIYTEKSAVDFMNRPLALEWCMYFFPNLFRFFFDHRQSVAFASFMLFSFLGVGFKIAAIQKYSGFFFLSVILYVSNLFFIMEMTTIRAGVAAGIFLFGLQYLEKRQHWKFLITLLCCLFFHSSGIVYVLVWALITARTKLKYYYIILAASVGIMILKVNILSLLLLDRVFPRVKIYFEIMQWQKEKSVNIFNFRVLFALVIIVSFMGFYRKLKNKPYFDLLFKTHLLSVSLFFAFSNLSQVFSLRTFDMFSVVQILLYPMFIYIFSPALKIWGWVIIILFSMLQIYYFVEVSEIFKVYRSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V2</accession>
    <name>C6X1V2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806700.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01973"/>
    <dbReference type="EnsemblBacteria" id="ACU08415">
        <property type="protein sequence ID" value="ACU08415"/>
        <property type="gene ID" value="FIC_01973"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01973"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541569_0_0_10"/>
    <dbReference type="OMA" id="YASWNPY"/>
    <dbReference type="OrthoDB" id="909102at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="329"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="503" mass="55099" checksum="93C63FBD46B2C1B1" modified="2009-09-22" version="1">MNKFFLMLFVAITAMSCSKKVEVKGNFAGGSPLERIEFIEASGVATLPLVNLGVDSKGSFSGSFEAPKNGMYIMTYAGKTAMIYLKGGQELNISGQAANFPQQFTITGDAKNNNDFLLEVQKFIQGYASNINVGELVTKKEPEFLKAAEKLRADLEKSIDAAADKTSADKEVVNWKKDELNASVLSLMSQYEANHPQATQNPSYKPSKNFIDTEKNLVQDEKRMLRTQPIYRNYLLSKLSPEFQKFATAQAPAPGALSSEVFAKFLDTKKEMPQLTKDYLLAFVLSSSDIAPGMTAENVGKINKLVQDKIKDADIRKDIEKVQFVIAGPKMGEAAPASKLIKQDGSAANLTGGKGKPTLVMFYASWNPYISEGTVPVLREVVNFYKSKVDFTFVNLDDTKKQFTKTSNAMLKGIQGANVYGEGGMSSAVAKDYGIYGFKMPSFIILDKDGKVASRFFYNLGDPEIVTALDKISGLKAPTVQPEVQLQNDLLAPPQEMQPQTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X204</accession>
    <name>C6X204_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferrichrome-iron receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806751.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02025"/>
    <dbReference type="EnsemblBacteria" id="ACU08467">
        <property type="protein sequence ID" value="ACU08467"/>
        <property type="gene ID" value="FIC_02025"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02025"/>
    <dbReference type="eggNOG" id="COG4774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_10"/>
    <dbReference type="OMA" id="GRLDWYD"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="60"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="283"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="721" mass="79887" checksum="82BA734A5E6B2B90" modified="2009-09-22" version="1">MKNILVPAAFLIGLISIKAQQTATERDSLKQAEIDQVELFGVAKQQPVKLETITRLPLKTRDQIQSISVVSNKVIEQLGGLTVTDVAKNIPGVTQFGSYGGTKESMSIRGYRGVPVLKNGVAMDSDFRTGSMLTDMQGVETVQVIKGSAAVTQGIGDGLGAAGGVINVVTKVPKFYNATNVGFRYGSWDFYRPTVDFQRVLDSEGKFAVRFNGAYQNSNSFRKYVNTERIYINPSIAYRPDDKTSVILEMDYMHNDVTPDRGTVNLADGNVNAIYEMPEGKFLGFQTDNNNSKTFNFSSTVVRKLTDQLKIRTAYMNSSYQQDNVGASLGTIKNQPWEIRRRSLSRSERDDRNQVFQADFIGEDVKIGFLKHTFQVGFDWKESDVTTTSYGAVVVDQINVLQDINNNLPNAVNFGTGTNVNAKTPSIGLMAQDLITWNKYIKTHLGVRYSKLNGTSEDKENATWNPSLGLIISPRENVNLFGSYTTTTSLRSANNRLLDGGTVGAADAVQFEAGIKSDWLDEKLRFNLTLFDIKNDNLSYSILNADGTATGFYGLAGQLRRKGVEVELIGKILPNLQVMTGWAYLDAQYHNSPAYVEGSAPMNAPKHTANGWLNYKFDSGILNRFDMGAGIYFVGERPVDEFTQTTIVSGHANSVTPGLEPFLMNSYTTVDAQIGYSQNNIGVRVFFNNIFDALGYNSYFRGGYLDQIQPRNFSIQLNYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X213</accession>
    <name>C6X213_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806760.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02034"/>
    <dbReference type="EnsemblBacteria" id="ACU08476">
        <property type="protein sequence ID" value="ACU08476"/>
        <property type="gene ID" value="FIC_02034"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02034"/>
    <dbReference type="eggNOG" id="COG2350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133148_0_0_10"/>
    <dbReference type="OMA" id="GADDYGM"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972234" description="YCII domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="YCII" evidence="3">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="159" mass="17828" checksum="67124F8FA6503036" modified="2009-09-22" version="1">MKNLIVLCLIWFACGLQAQNISLESGKANYDKKLADSLGADERGMKNYMLVILKTGPRDSVITDKKQREELFKGHFSNMDEMEKSGRLKMAGPFATKNNLGYRGIFLLDVKTEAEAKSLLEKDPTVKNGIFEVEILPFYGSAAIPMHLKFHEKISAQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X232</accession>
    <name>C6X232_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806779.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02053"/>
    <dbReference type="EnsemblBacteria" id="ACU08495">
        <property type="protein sequence ID" value="ACU08495"/>
        <property type="gene ID" value="FIC_02053"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02053"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005386_0_1_10"/>
    <dbReference type="OMA" id="NCRLPQT"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_63" evidence="2">
        <location>
            <begin position="686"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="870" mass="101539" checksum="E64E8A149F736AF1" modified="2009-09-22" version="1">MIVEEQRMADEKWKKWGPYVSNRQWGTVREDYSQNGNAWGYTTHNEAISRAYRWNEDGIAGICDDKQRLCFAFSFWNGQDDMIKERFFGLSNHEGNHGEDIKEIFYYLDNTPTHSYMKMVYKYPTVKFPYREIIDENRSRTKREPEFEITDTEIFSNNQYFDLFIEYAKINHDDIAIRITAINRSSGKAPLHILPTLWYRNNWAWGNGSYRPELRSSRDGIIDIGHESICMKKLYARNPETAALFCNNESNPAVVLGAASDAAFFKDGINNFLIHDDFNAVNPGQTGSKAAFHVKAELEAGETKTFDFRLSPHTMDDAFFDFDEVFRLRKEEADLLYEKIQCDISDVEEKNIQRQAFAGLLWNKQFYYYNVSKWLKGDAKYPAERDFGNFVRNTGWEHMQNKDIISMPDKWEYPWFATWDLAFHCVPFAILDPGFAKHQLKLLTKEWYMHPNGQLPAYEWDFSDVNPPVHAWSTFRVFKIDEKFHGKPDIPFLESVFQKLLLNFTWWVNRKDKNGNNVFGGGFLGLDNIGAFDRNMKFKNGDYLEQADGTSWMAMYALNMMRISMELALYNSVYEDMAIKFFEHYLYIAEAMENIGELKGGLWNEEDGFFYDVLQLNDGDSISLKLRSIVGLIPMFAVEIVEHETLEKLPNFRARMEWILKNKPELANLVSHWEVEGKGGKHMMSVLRKTRLRRILERMLDENEFLSPHGIRSLSKIYQDHPYVFSADGTDYVVKYTPAESDSRMFGGNSNWRGPIWFPINFLIVESLQRYHYYYGESFQIEFPSGSGQKCNLGYVSDDLGSRLCSIFIKDENGNRPFNGQNYFLSQNEHFKDYIMFNEYFDGDTGKGIGASHQTGWTATVAKLLKPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X233</accession>
    <name>C6X233_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC/Ohr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806780.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08496">
        <property type="protein sequence ID" value="ACU08496"/>
        <property type="gene ID" value="FIC_02054"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02054"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114057_1_1_10"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="148" mass="16132" checksum="1A03F0C56E474A31" modified="2009-09-22" version="1">MKVSLQRINDDFLFKCTNSAGNTIHLDNTSEPNPQGVSPMESILMATAACSSIDIVSILKKQRQTITSFSAEVEGERVQVDEAKPFRSITVIFFLEGVIEPQKALKAATLSFEKYCSVSKTLEPGVEVNYRVFVNGAQVDVPATDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X294</accession>
    <name>C6X294_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08557">
        <property type="protein sequence ID" value="ACU08557"/>
        <property type="gene ID" value="FIC_02120"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02120"/>
    <dbReference type="eggNOG" id="ENOG503336D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2477750_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038444">
        <property type="entry name" value="DUF465_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="86" mass="10399" checksum="661539863AC4DCE5" modified="2009-09-22" version="1">MMIAKKSYRKFHPQQKEIEALEKKNDRFKRIFTEYEHMAEELWDLENSDVSNIPDDFINAMKVQTEYLEDEIGDWLATENKSLDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D7</accession>
    <name>C6X2D7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ordered locus">FIC_02164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806884.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02164"/>
    <dbReference type="EnsemblBacteria" id="ACU08600">
        <property type="protein sequence ID" value="ACU08600"/>
        <property type="gene ID" value="FIC_02164"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02164"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_10"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="206"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="318" mass="35798" checksum="D129B8021EBA8227" modified="2009-09-22" version="1">MKSLKIVFFGTPEFAKTSLAAIHNSHHEVVGVVTVADKASGRGQKIQQSPVKVFATENDLPVFQPEKLKDPEFLDSIRQLNADIFVVVAFRMMPKILFEMPEKGTFNLHASLLPDYRGAAPINYAIINGEKKTGATTFFINEKIDKGNILLQDEIEIFPNENAGELHDRLMEMGAQLVIKTLDGLAENSINEMPQPEVANPKNAFKIFKDDLRINWKQDGAKVHNFIRGMSPYPCAFTVLKIGEEQKSLKIFKGKFGEDEHSETAGSLKIDKNTFKIFTSDGAYFPEEIQLEGKKRMNVKDFLNGFRDYDHILMAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2I9</accession>
    <name>C6X2I9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-CoA oxygenase, PaaI subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806936.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02217"/>
    <dbReference type="EnsemblBacteria" id="ACU08652">
        <property type="protein sequence ID" value="ACU08652"/>
        <property type="gene ID" value="FIC_02217"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02217"/>
    <dbReference type="eggNOG" id="COG3396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070585_0_0_10"/>
    <dbReference type="OMA" id="NGDFAHT"/>
    <dbReference type="OrthoDB" id="1389523at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011882">
        <property type="entry name" value="PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037834">
        <property type="entry name" value="PA_CoA_Oase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02158">
        <property type="entry name" value="PA_CoA_Oxy3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="249" mass="28708" checksum="D69B8A62147A8CCD" modified="2009-09-22" version="1">MNPLFNYILKLADDTLIFGQRLGELCGQGPYLEEDIALTNIALDYLGQSNNLYKYAAQIQGEGKTEDDLAFLRLEKEYLNCQLSELPNGDYANTLLKVYFFAVYQKILYTELMKSSDEQLAGIAEKSLKEVKYHYTHTSTWVKMFAGGTEESKTRLHNAVENLWEYTAGMFAETPGESELSNLEIVPDSAFIKDIWNQVIREDFGNFGIEIPENEFMQKGSRTGYHTEYFGFILCELQYMQRTYPNCVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M4</accession>
    <name>C6X2M4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806971.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02254"/>
    <dbReference type="EnsemblBacteria" id="ACU08687">
        <property type="protein sequence ID" value="ACU08687"/>
        <property type="gene ID" value="FIC_02254"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02254"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084727_0_0_10"/>
    <dbReference type="OMA" id="HPYCKGV"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="286" mass="32490" checksum="555C9C28ACBC213A" modified="2009-09-22" version="1">MIAIVDGGSTKCDWVILENSGKFNLKTTTLGFNPNIINPDFIPQEINRNEELFFLRNHIEKLFFYGSGCGTPHNAKKVEDEFKAMFPHAEVSIKEDMTAAAYAAYNGVPAIICILGTGSNSCFFDGEKIRTDLPSLGFLIGDEGSGSALGKHLLRRFFMKKLPADLEAEFIKTYNLTIEEAIQKMYHNPRANAYLGEFNKFIADHRKHPYFQNMVFDEMKNFLDYQVLPYPEAGKVEINFIGYIAYIYEDILRSAAAELNLKIGKVVQKPIESLVNYHKKYILDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M9</accession>
    <name>C6X2M9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806976.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02259"/>
    <dbReference type="EnsemblBacteria" id="ACU08692">
        <property type="protein sequence ID" value="ACU08692"/>
        <property type="gene ID" value="FIC_02259"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02259"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134907_0_0_10"/>
    <dbReference type="OMA" id="NNCTITP"/>
    <dbReference type="OrthoDB" id="1584852at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973379" evidence="1">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="159" mass="16553" checksum="A400B7B44116200E" modified="2009-09-22" version="1">MKKALAMAALALAVSFGTVACKKKVTDAELQTQATTVVTSNPNASVEVKDGTAHLSGTFADEASRDQMLASLKAIPGIKEVMDMSTIAAAPVVETVSAVDPAVQQKVADAVKDFPSVNVEVVNGELTLTGNVSPEQARKIKMSVDALQAGTVNYNYTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T7</accession>
    <name>C6X2T7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02317"/>
    <dbReference type="EnsemblBacteria" id="ACU08750">
        <property type="protein sequence ID" value="ACU08750"/>
        <property type="gene ID" value="FIC_02317"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02317"/>
    <dbReference type="eggNOG" id="COG2913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_1_10"/>
    <dbReference type="OMA" id="LAECYAN"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="100"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="381"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="548" mass="59759" checksum="11B445DCA68E3A32" modified="2009-09-22" version="1">MLHLVSGYSAWALIFHYKFLITMKKNIITKIGLLLSLSVVAFTATSCSRDEIIDLKPFNSIDENLAFSTASNVDLTVMGVYNAAQNGFYYTAPGAANTPRGYAFGSAYTVQGDMRGEDMVNNATFYQLTYTATYDAGTPNNVHHFENLYALINKANIVIDGATTAATNGVISAAVKDGYVGEMYFFRALAHLELLKHFARPYNFTAGGAHQGVAYRDFAITTPATIDLAAAVRRGTVADNYAKILADLDNAETLMPSKTTRTGNMKITRASKEAAVALKVRAYLNMRNWNNVLVEGAKLATAYSLGAPSAPFTSNYGNPESIFSIENSAVTNPGVNAALASMYNNRSLVNISPIIWRNPRWTATDKRREEGTMVRTPVSGVKFTNKYKDVTNLSDATPILRYAEIVLSMAEANARLGNSGAALTQLNLVRNRALAAPATEAYTAASFANATEMVDAIITERRIEFLAEGMRWNDIHRLLYDDLVPMPGIPAKLANGMPTGAMFTLGTPYTGPYGVAMIPKEDFRVLWPIPLSTTVNNPIMQEEQNPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V5</accession>
    <name>C6X2V5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807052.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02335"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08768">
        <property type="protein sequence ID" value="ACU08768"/>
        <property type="gene ID" value="FIC_02335"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02335"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_4_10"/>
    <dbReference type="OMA" id="NDIVAYR"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="321" mass="37468" checksum="908002A99E3AB7FE" modified="2009-09-22" version="1">MEDKKISVIMSVFNAEKYLVEALESILNQTDSHFEFIIIEDASTDGSLKILEDYQNRDPRIILIKNDVNKGAAGFIKNLNMALEKATGEFIARMDADDISDLRRFEKQTTFLEENPDVFIVGSTIEIIDEKGANLKLLSLPTDDGDIQQKMPKNISLYHPVVMWRNNRKTFYREKMIACEDYDLYFRLMTDGLKFGNIDEPLLKYRILGNSISRKDDKLIKWLFVEKARTFYHERKRKNTDSYDQFEPQNYLNILNTAYKNNITDLSFAAKTAAKYRNYDALAAVLRKAKQHFPNEKLFIFFSLYLSVSRNLFPHKKISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W4</accession>
    <name>C6X2W4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ordered locus">FIC_02344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807061.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02344"/>
    <dbReference type="EnsemblBacteria" id="ACU08777">
        <property type="protein sequence ID" value="ACU08777"/>
        <property type="gene ID" value="FIC_02344"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02344"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_10"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="21114" checksum="07904A55B6B75113" modified="2009-09-22" version="1">MKYLIVGLGNKGDEYTETRHNVGFKVAEKIAETIEAPFKPSNFGLMAEGKYKGRKVFILKPDTYMNLSGNAVKFWLQKENIPVENLMIVTDDLSLPFGTLRMKMKGSDAGHNGLKSIQEQLQTQNYPRLRFGISAEFSEGKQVDYVLGKWSEDEKEKLPERIEKFSKACLSFVFAGIQNAMTGFNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z5</accession>
    <name>C6X2Z5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02375"/>
    <dbReference type="EnsemblBacteria" id="ACU08808">
        <property type="protein sequence ID" value="ACU08808"/>
        <property type="gene ID" value="FIC_02375"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02375"/>
    <dbReference type="eggNOG" id="ENOG503334S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107087_3_1_10"/>
    <dbReference type="OMA" id="NFQRGKE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="19180" checksum="EAE941ECEE09E1E5" modified="2009-09-22" version="1">MALYLSRTTIMIHKMKKFLHIPAFLLLMVIMSFGAADFYSSMTKVDYVEGSKTLKFTTKLNTQHISDAIKINPNTTGFEAEVKKYVNNNFDLFINGGSKTLTFTGSQVNGESTWVYFEAGGVTDVNTIKIKNTILLSTFPKQFNLVNIAYKGNQKTMNFQRGKEVNEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z7</accession>
    <name>C6X2Z7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807094.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02377"/>
    <dbReference type="EnsemblBacteria" id="ACU08810">
        <property type="protein sequence ID" value="ACU08810"/>
        <property type="gene ID" value="FIC_02377"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02377"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316392_0_0_10"/>
    <dbReference type="OMA" id="NWGGLND"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973517" evidence="1">
        <location>
            <begin position="22"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="918" mass="103672" checksum="45B861C60193D75F" modified="2009-09-22" version="1">MIKKLSLISLFTLLPASFYFAQTTVYAYVKDQEGKPVENAQVDLGESTNSLTSDKIGYFQFVDLMPGHYQITVSKQSFEPKVIEFDVATEEKRKDLGVISLAVGTISTAGVMVIDDSASDGDEGGSSMQPTIGLLNAGRDIFQSVSAFELGAYWFRPRGVDNRFEEVLFNGIPMSKNDDGRIDFSNWGGLNDVTRYPYESVDNITPSEYTFGNLGGVVYYNTRASSYRKGVSLAYSATNRSYNNRVMATYNSGLLRNGWAFTFSGSRRWAEEGQIEGTYQDAYAYFGSIEKRFGENHSLNLTAFGTPTYRASNSPNTQEVYDIMGKDYNSYWGWQDGEKRSSRVRKVFEPIFQLAHYWKVNKNSNLNTTVSYQQGSDARSRLDWFRGADPHPHYYRKLPSYGLNTVEEYKAIAQIDWTDLYYQNSNVNPATYTFGDESITGRRSIYSLVEDVNEDKTINVASHFDTKLQENWKLNINLNYQNLQSDVFRRVKDLLGGDFAFNRNAFDGDAFYNIDDPNYIVKVGDRTQFSYDLLRSTYSANVSTEVDFPKWNVVASLFSSYSESQRDGHFRSARYADNSKGRSDIFSAFDAGVKGKVTYKINGKNFLVYNGAFFSLAPTLNEIYINPRAVDYLTPGVDNQIINSNDLSYILRGQIFKVRLSGYYTTISNATEISRYYADVDAGSGTSLSTLVNEAMSGADKRYMGAELGLDVKITPTLNANLVGSYGDYEYTNNPSVSTFDDLNNFRNEDYWRGKANIEGYKVAGTPQKAFSAGLRYNSPKFWWLGVTGNYLMDQYLDFSALNKTPRLYYNPVTGDNYEGATPEVIAALTAQKKFDDQFMLNANAGKSFLLGKYRMGLSLSVSNILNNRNYVTGGFEQGRNVNFVNAIEDAERATPFFGPKLWYDRGTQFFANVYLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X366</accession>
    <name>C6X366_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807163.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02446"/>
    <dbReference type="EnsemblBacteria" id="ACU08879">
        <property type="protein sequence ID" value="ACU08879"/>
        <property type="gene ID" value="FIC_02446"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02446"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762368_0_0_10"/>
    <dbReference type="OMA" id="YIDFAKG"/>
    <dbReference type="OrthoDB" id="643041at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="363" mass="42217" checksum="AAA372F330819A63" modified="2009-09-22" version="1">MKRDLYIDFAKGFATLAIIFIHTVFWSGQFYIPTEMRVLSLLIDVPLFYALSGLTSGGNIEKTLYRLLKLQITFMIFVTFLFLLDYLFKVFGLNVFGLAWMQDFYSTFGTKYVPQNISDVPQWQNLGNWYLHQYTNADTFPVVMGSFWYLKVYFILTVFGVLILKFFPKHVKWFIALCFGLTLLFNLFPHYYPTGQVGYVALYLGVFLLANQLKGKKIPTKIAAIMYAILAVILIILFWNEGKELFLKMNKAKFPPKLLYVFWSSFSLLTLFVLYNRIKISRDSIITYIGKNAIFFYFAQGMSSSLVYFFVVPLKDSMSWWLLMILIYAINVILAFGIAVCLKKLDAVGWRILEFLRKKTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X387</accession>
    <name>C6X387_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein ftsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807184.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02467"/>
    <dbReference type="EnsemblBacteria" id="ACU08900">
        <property type="protein sequence ID" value="ACU08900"/>
        <property type="gene ID" value="FIC_02467"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02467"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_1_0_10"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="409" mass="45114" checksum="183F40AE13B64DEF" modified="2009-09-22" version="1">MQETENKFELLKGDKVLWSVVLLISFFSVFPVYSASSNLEYIVNSGTTTSHLFKHTFFVVLGLAIMRGVGVFKYEYIGKLSSIGLVVMIMLLGLTMVTGQTIDGASASRWLKIPGTPISFQPSSFAYLLLVIYLCRYLTKKIKRERHTWENILFVFGPVLLVFGLVAKDNGSTALMILIVSLAVMLIGQLNKKYILGFCGLSAAAIGIFMFLALKTDIIENNRVHTWMSRIEVFFDSKQENQIENEIDKAKNYQVMQAKAAIVHGGIAGMGPGKSALKQMLPQSASDFIFAIIVEEYGFVGALVLISLYLIMIIRIVMIASKMPAFFGSLLVLSLGLMIFVQLAVNIAVAVNLIPVTGQPLPLISYGGTSMLVTYIQLGIILNVSSRIQVYDEEGMGKKQNIEEINDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C1</accession>
    <name>C6X3C1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="4">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aat</name>
        <name evidence="5" type="ordered locus">FIC_02501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the L/F-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807218.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02501"/>
    <dbReference type="EnsemblBacteria" id="ACU08934">
        <property type="protein sequence ID" value="ACU08934"/>
        <property type="gene ID" value="FIC_02501"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02501"/>
    <dbReference type="eggNOG" id="COG2360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075045_0_0_10"/>
    <dbReference type="OMA" id="YRQGIFP"/>
    <dbReference type="OrthoDB" id="1670846at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042221">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="216" mass="24534" checksum="39874EAB63C0B141" modified="2009-09-22" version="1">MIYLNADEISFPDPEFMDSEGGLLAVGGDLSPERLLFAYQTGLFPWFNEGEEILWWCPDPRFVVVPAEIKVSKSMKKILKAGVFTFTENKCFREVMLGCKNSYRKDQDGTWISMDLIDSFTVLHQHGFAKSVEVWQDEQLVGGFYGVQIGKVFCGESMFSKVSNASKAGFLNFVLNNSENFDLIDCQIHSDHLESLGAKMISKLEYLKILKRNNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J9</accession>
    <name>C6X3J9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="12" type="ordered locus">FIC_02582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807296.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02582"/>
    <dbReference type="EnsemblBacteria" id="ACU09012">
        <property type="protein sequence ID" value="ACU09012"/>
        <property type="gene ID" value="FIC_02582"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02582"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_10"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU09012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="396" mass="42584" checksum="B5458DE947A35295" modified="2009-09-22" version="1">MKTVNDFDFKDKKALVRVDFNVPQSADLKITDGTRIEAVKPTIDKIIGDGGSVILMTHLGRPKGKFTEDFSLKGIVAEIGEILGRDVKFCADCIGQDATDMSGNLQPGEVLLLENLRFYSEEENGDAAFAEKLSKYGDAYVNDAFGTAHRAHASTAVIAQFFPQTKFFGLLMAKELEAVDKVLGSGEKPVTAILGGSKVSTKITIIENILPAIDNLIIGGGMAFTFIRALGGRIGNSLLEEDKMNMALSILEKAKEQNVKVYLPSDTVIADEFSNDADTREEDIYDIPDGWMGMDAGPKTRLLFHDVLLNSRTILWNGPIGVFEMPNFSAGTVALGESIAEATRLGAFSLVGGGDSVAFVKQFGYEDKVSYVSTGGGAMLESLEGKELPGVKAINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N1</accession>
    <name>C6X3N1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782166.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00561"/>
    <dbReference type="EnsemblBacteria" id="ACU07019">
        <property type="protein sequence ID" value="ACU07019"/>
        <property type="gene ID" value="FIC_00561"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00561"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914479_0_0_10"/>
    <dbReference type="OrthoDB" id="1344190at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973667" evidence="1">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="268" mass="29042" checksum="2633428F73859BC4" modified="2009-09-22" version="1">MKTKILILITGTLLFGSAKAQTLISTNATLAATPDPSSALHVADDKRGVLLPQVYLTSATDNVTVPTPTQGLLVQNTNSNKSNFWAANKWNRNFEVSDGLAIIKQTENFTGKSTASTTISGFPAIVPLFNLNDSTTGWTDLNATSNMTITKLTNTTYIVAEGMAQIDNITATDQKFQFAIGIFVNGQLKMASKYYTTTSEFVCSWRKFNLSGVINNLPVGTHTVKVYGRNLPKDTSGYTHIVYGGNTTNCSNINNDMARIFVTAQTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N4</accession>
    <name>C6X3N4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ordered locus">FIC_00564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00564"/>
    <dbReference type="EnsemblBacteria" id="ACU07022">
        <property type="protein sequence ID" value="ACU07022"/>
        <property type="gene ID" value="FIC_00564"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00564"/>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_10"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="212"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="241"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="453" mass="50041" checksum="1A733050278D72CE" modified="2009-09-22" version="1">MGQELVRKFAKNYSFNMETSTQYLPYKVKDISLADWGRKEIKLAEAEMPGLMAIREEYGPSQPLKGARIAGCLHMTIQTAVLIETLVALGADVTWSSCNIFSTQDHAAAAIAAAGIPVYAWKGMNEEEFEWCIEQTVFFGEDRKPLNLILDDGGDLTNLVFDKYPELTAGIKGLSEETTTGVHRLYERMANGTLVMPAINVNDSVTKSKFDNKYGCRESAVDAIRRATDLMLAGKRVVVCGYGDVGKGTAASFRGAGSIVTVTEIDPICALQAAMEGYEVKKLDSVVANADIIITTTGNYNIVRGEHFKQMKDKTVVCNIGHFDNELDMAWLNENYSDTKYEVKPQVDVYNIDGNEIIILAEGRLVNLGCATGHPSFVMSNSFSNQTLAQIELWVNGAAYKNEVYTLPKHLDEKVAALHLKKLGVELETLSPEQAKYIGVTVDGPFKPEYYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y2</accession>
    <name>C6X3Y2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782266.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00665"/>
    <dbReference type="EnsemblBacteria" id="ACU07120">
        <property type="protein sequence ID" value="ACU07120"/>
        <property type="gene ID" value="FIC_00665"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00665"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_0_10"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="216" mass="24116" checksum="C85E722B729BB266" modified="2009-09-22" version="1">MTTVLSDQFSLINTWINELRNVELQGDRMRFRRNMERIGEIAAFEISKGLEQKEIEITTPLDRIKVKEIAVQPVITTILRAGVPLFQGILNYLDKADCGFVAAYRKHDANDYFSIKQDYLTCPNIDGRPLIVADPMLATGASLIEAIKDLLNHGKPSQLHIVAAIASRQGVETIQKEYPEAKIWVGVIDENLTSKGYITPGLGDAGDLSYGEKLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z9</accession>
    <name>C6X3Z9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pfkA</name>
        <name evidence="17" type="ordered locus">FIC_00682</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782283.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00682"/>
    <dbReference type="EnsemblBacteria" id="ACU07137">
        <property type="protein sequence ID" value="ACU07137"/>
        <property type="gene ID" value="FIC_00682"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00682"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_10"/>
    <dbReference type="OMA" id="KFAVICV"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="8"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="26"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="258"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU07137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="328" mass="35070" checksum="D2FDD1A8702A48CE" modified="2009-09-22" version="1">MKESAVKKIAVFTSGGDAPGMNAALRAVVRTANHYNIECYGVREGYNGLIHDDFTRMGPRSVKNIITEGGTVLKSARSEEFKTKAGRQKAYDNCVKHGIDALVCIGGDGTFRGANIFNEEFGIKVIGVPGTIDNDIFGTDNTIGYDTALNTAMEAIDKIRDTATSHNRVFFVEVMGRDAGFIALNSGLATGAIDILIPEKKDSIDDLFKTFERAEKAGKSSSIVVVAEGEKLGSIYDLAKATKAGFPDYDIRVAVLGHIQRGGSPSCADRVLASQLGYGAVVGLMEGRTNVMAGLKSNVLVYTPIEEAIKKHNEIDAGLLKISEILAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X414</accession>
    <name>C6X414_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="3 6">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00697"/>
    <dbReference type="EnsemblBacteria" id="ACU07152">
        <property type="protein sequence ID" value="ACU07152"/>
        <property type="gene ID" value="FIC_00697"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00697"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_10"/>
    <dbReference type="OMA" id="SRMRHHC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="PTHR11624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="335" mass="37477" checksum="CDA395715082C8F9" modified="2009-09-22" version="1">MYSNFSMNMKEYTFREVIAQAMSEEMRKDESIYLMGEEVAEYNGAYKASKGMLDEFGPKRVIDTPIAELGFTGIAVGSAMNGNRPIVEYMTFNFALVGIDQIINNAAKIRQMSGGQWNCPIVFRGPTASAGQLGATHSQALENWFANTPGLKVVVPSNPYDAKGLLKSAIQDNDPVIFMESEQMYGDKMEIPEDEYYIPIGKADIKREGKDITLVSFGKIMKLAMQAAEDMEKEGVSVEVIDLRTVRPLDYDTIIESVKKTNRLVILEEAWPLASISTEISYMVQQKAFDYLDAPIKRITTPDAPAPYSAALFAEWFPKLETVKEEIKKAMYIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X457</accession>
    <name>C6X457_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase RhlE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782341.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00740"/>
    <dbReference type="EnsemblBacteria" id="ACU07195">
        <property type="protein sequence ID" value="ACU07195"/>
        <property type="gene ID" value="FIC_00740"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00740"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_28_3_10"/>
    <dbReference type="OMA" id="EIKQESM"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="216"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="417" mass="46360" checksum="4B7A09DA3C469F50" modified="2009-09-22" version="1">MNFTDLQLIDPIAKALQEEGYTQPTPIQAKAIPSILQGRDLLGTAQTGTGKTAAFAIPILQNLTEKNIRNNQIKALILTPTRELAIQIEESFNAYGRHLRLRNLVVFGGVKQSGQEAALKKGVDILVATPGRLLDFISQGIISLKNLEIFVLDEADRMLDMGFVHDVKRIIKLLPPKRQTLFFSATFPDEISKLANSMLTNPVKVEVAPVSATADTIKQKVYFVEKENKLELLTHILMNDISDSVLVFSRTKHGADKIARKLQSHKISAEAIHGNKSQNQRQNALNNFKSGKTRILVATDIAARGIDIDELKYVVNFELSDVSETYVHRIGRTGRAGADGSSISFVDGLDLVNLKSTEKLIGKKIPVEKDHPFHTDNLKEEKRDSNNKPFTPRPRAQGRESIGSKKPNNKSNFTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X465</accession>
    <name>C6X465_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phage-related protein (Hydrolase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782349.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00748"/>
    <dbReference type="EnsemblBacteria" id="ACU07203">
        <property type="protein sequence ID" value="ACU07203"/>
        <property type="gene ID" value="FIC_00748"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00748"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057859_1_0_10"/>
    <dbReference type="OMA" id="FQIMGYH"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024408">
        <property type="entry name" value="Muramidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11860">
        <property type="entry name" value="Muramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Muramidase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="273" mass="30867" checksum="12BCEAE46AF4DF34" modified="2009-09-22" version="1">MITLKVKAKAPAVYTLCEMLSKLGYPVKISDSFTAEVDAAVKDFQKKNALVVDGVVGMKTWQVLMDKSSKIFKTNNLFLSEQDLKDFAKSFNLELAAVKAVNEVESSGKGFLINGKPKILFEGHCFWQQLRKSGINPEKLLNTTNRNVLYPKWTKSFYVGGAKEYDRLNQAIAISIDPKVKEAALAACSWGSFQIMGYHAKSLGYPSVQNFVDHMHLHEREHLLAFGKFLEVNKIMADLRSKNWAKVALKYNGAGYKKNQYDEKLKKAYEKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C8</accession>
    <name>C6X4C8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15 16">Protoporphyrinogen IX oxidase</fullName>
            <shortName evidence="15">PPO</shortName>
            <ecNumber evidence="15 16">1.3.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">FIC_00813</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:62000"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15 16">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cell membrane</location>
            <topology evidence="3 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15 16">Belongs to the HemJ family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="15 16"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782412.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00813"/>
    <dbReference type="EnsemblBacteria" id="ACU07266">
        <property type="protein sequence ID" value="ACU07266"/>
        <property type="gene ID" value="FIC_00813"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00813"/>
    <dbReference type="eggNOG" id="COG1981">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125006_0_0_10"/>
    <dbReference type="OrthoDB" id="1433260at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070818">
        <property type="term" value="F:protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02239">
        <property type="entry name" value="HemJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005265">
        <property type="entry name" value="HemJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40255">
        <property type="entry name" value="PTHR40255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03653">
        <property type="entry name" value="UPF0093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004638">
        <property type="entry name" value="UCP004638"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="13 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU07266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="183" mass="21727" checksum="C764C3794FEE1ED0" modified="2009-09-22" version="1">MLYTVLKAVHIIFMVSYFAGIFYLVRIFVYYKDTDAFDENKKNILREQYVFMARRLWNIITVPAGVIMLLSGLTLIFLNFGLMKTPWFHLKLTFLLGLTFYHYWCWQKVLQIKNLNGNLLSVENIKLRQANEIATFILFLVVFTVILKSMVIEYWWQLISGFIIFVFAVMLTVKLVNRKKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K7</accession>
    <name>C6X4K7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ordered locus">FIC_00892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782491.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00892"/>
    <dbReference type="EnsemblBacteria" id="ACU07345">
        <property type="protein sequence ID" value="ACU07345"/>
        <property type="gene ID" value="FIC_00892"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00892"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_2_3_10"/>
    <dbReference type="OMA" id="EWRLFLI"/>
    <dbReference type="OrthoDB" id="1942863at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="13175" checksum="10A58147CE77A421" modified="2009-09-22" version="1">MKNLVYIFIGGGLGSVLRFAVSTYSQKFYTFKSFPIGTFVVNMLGCLLMGVLISLLARADSSVKYLLITGFCGGFTTFSAFSAENASLWQNGNYFIVLSYILLSVFIGIGAVYTGMQIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M3</accession>
    <name>C6X4M3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782507.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00909"/>
    <dbReference type="EnsemblBacteria" id="ACU07361">
        <property type="protein sequence ID" value="ACU07361"/>
        <property type="gene ID" value="FIC_00909"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00909"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862736_0_0_10"/>
    <dbReference type="OMA" id="FTHGYLR"/>
    <dbReference type="OrthoDB" id="1714999at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="67"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="321" mass="35471" checksum="5F7E4F36E1CF3E36" modified="2009-09-22" version="1">MSLTFLLLLIIALAVIIGVITKKLDILTYSAPDKNGRQIPNGIKWKPLTFIFLACIAALVQPMNYEVISVGHKGLLINLLGDKRGVSYTEEVSGVVFYNKYTQEIQEIPLDQRHIEYPESIIVAKGGFPCPIKPSFNYSVKESTAADMFTNLRSTYKKGGLEAIQEGWLNNAIIGAINDVANRHSIDYLFNNRETYEAEILSEVNKRIGKWFLVSQLKTNIQPPKAIRQSIEDKATADADAIKAEAQARVAQADAQRKIQLAKGDSASVVIRAQADAKAISLKQQEITQTYVEYQRVLKWDGVMPTTVLGSGSGTLLNVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M5</accession>
    <name>C6X4M5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07363">
        <property type="protein sequence ID" value="ACU07363"/>
        <property type="gene ID" value="FIC_00911"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00911"/>
    <dbReference type="HOGENOM" id="CLU_3381968_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="33" mass="3868" checksum="4704A610FABB8DAF" modified="2009-09-22" version="1">MEDTAKKDNPSKNDLIKMVLILRIIVRIEIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P7</accession>
    <name>C6X4P7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ordered locus">FIC_00934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782531.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00934"/>
    <dbReference type="EnsemblBacteria" id="ACU07385">
        <property type="protein sequence ID" value="ACU07385"/>
        <property type="gene ID" value="FIC_00934"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00934"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_1_10"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="255" mass="29075" checksum="57888FA9108B7C62" modified="2009-09-22" version="1">MSVKAKKHLGQHFLIDENIAKKIVDSLSYSQYTQVLEVGPGMGVLTKYLLEKETEVFVAEIDRDSVAYLKNHFPKLEARHFSDDFLKIDIAESFGDQVAVIGNFPYNISSQILFKIIDFYDRVPEMVGMFQKEVAERTAAVPRTKDYGILSVLVQALYDVTYLFTVHENVFNPPPKVKSGVIRLTRNPKEGLAGNEVLFKKIVKAGFGQRRKKLSNSLKVLEIPEAMQNHPFLEKRAEELSVQDFISFTIEWKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S1</accession>
    <name>C6X4S1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyl-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782555.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00958"/>
    <dbReference type="EnsemblBacteria" id="ACU07409">
        <property type="protein sequence ID" value="ACU07409"/>
        <property type="gene ID" value="FIC_00958"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00958"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_2_1_10"/>
    <dbReference type="OMA" id="HITIPGF"/>
    <dbReference type="OrthoDB" id="275025at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="199"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="460" mass="51189" checksum="7F8161663704ED9B" modified="2009-09-22" version="1">MQETLNYIQENKQRYVDELFGLLRIASISADPAYKDEVLKCADEVAKYLKNAGADHVEVCETEGYPIVYGEKILDKDLPTVLVYGHYDVQPPDPLELWTKPPFEPYIEKTAIHPDGAIFARGSADDKGQFFMHVKAFEAMMKTNTLPCNVKFIIEGEEEVGSKSLGAFVKANTEKLSCDTILISDTHIYSNEQPTVTTGLRGLSYVEVEVEGPNRDLHSGLYGGAVPNPIHVLSRMISKLIDDDGHITIDGFYDNVDIVSEQDRAEMNKLKDDPENFKTSIGLKGDEGEKGYTTLERTSIRPTLDCNGIWGGYIGEGAKTVIPSKAFAKISMRLVPYQTPDEITEKFTKYFEKIAPDNVKVTVRPHHGGMPYVLPSDTKEFAAARKAMETAFGKEVLPYRSGGSIPITAMFEEVLGAKSVLMGFGLDSDAIHSPNEHYGLFNFYKGIESIPLFFENYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S3</accession>
    <name>C6X4S3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782557.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00960"/>
    <dbReference type="EnsemblBacteria" id="ACU07411">
        <property type="protein sequence ID" value="ACU07411"/>
        <property type="gene ID" value="FIC_00960"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00960"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_1_0_10"/>
    <dbReference type="OMA" id="YNGGMVP"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="248" mass="26377" checksum="A8E9ED636CA3AF49" modified="2009-09-22" version="1">MKILVCISSVPDTTSKINFTADKTAFDKNGIQWVINPLDEFALTKAVKLQESQGAVVTVLNVGEALTEPVIRKALAIGANEGIRINADPKDSFSVAKEIANVAQTGGYDLILCGKESIDYNGGAVPGMVAQLLNQPFVNACVGLEVNGGEVTAVREIDGGKETISVKLPAVIAGQKGMVDEKDLIIPNMRGIMSARTKPLHIQEATGSEVKVHGVSYDSVPARAAVKMVTPDNLDELVRLLHEEAKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W0</accession>
    <name>C6X4W0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00997"/>
    <dbReference type="EnsemblBacteria" id="ACU07448">
        <property type="protein sequence ID" value="ACU07448"/>
        <property type="gene ID" value="FIC_00997"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00997"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274280_0_0_10"/>
    <dbReference type="OMA" id="LICTESS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1204" mass="131732" checksum="CE76F1EDB0780923" modified="2009-09-22" version="1">MDGLQIKMYFWANFQMMKNFYILFIVLWSVLGWSQSVSLYNPGSGAAYPGEQFFCTGESFNLKVDAVATSTGDYKITKELPSSFPLSAGSTPINFQALNSNKFSESFPIGFTFSFYGKEYTRVVAGSNGRLVFTNDAELESLKDVSVYQDRTYSGIPASYGYSVLPSVDYNKVYKVNPAQELNLAQIFFGYTDLIPKSQNGSVTYLYKNITVEGQNVLLVSYQNQIRTDGVGGFSGSEKYSSTILLFEDGRIVIYVNNKILDTYNAILAIQNEDASKFKVPPHSNAASNYNNGPWRSEGVAWVFTPNLSLTPQFKWLRNGSQIPGETADTLTGFGPADGDVLKIEVTYHDTAGVQVGAAESDQVTFKLLKTPLISTPNYATGCGNPAEIHVIDPDPALTYEWLSETDPTFVRTGTSILVGNGTYYVRVKNTSGTCTLRSASEVVNITSSLPPFVYDGAMIRECDQLGLPSKNFDLATVTGYAAGSDYSVQYFETGSTTPVTSTTINSGQTKTFSITVSTNPGVTPSCSFTKTFSISYLSFPPDNTEFPSEKLCPEVNSYSAAQFKTRFFAGSSFMVMFSTDGVNFTLTSVNPQTNPSVWIRISDANFSCQSAVKLNFDFHPVVVANNPTTQLPPQCANPTETFDLASLIPEINADPNVTVTFHQNLPDAQNGVGAVPLNFRGGLGVTTLYVRAVNNITGCVSADHPIINLLVYKKPNLIVGNISKIQCEGSSVFNLTQNPTDLVVADPEVTVTLEYYAPNGTLLSGSQISNYDEAVSGANPYIKVVYNPTCSDIVTFNLSYNPKPTALIPQIPICGETTFALQDFKDEVIANSSQYTFTDENGNPLPASFDVSPGQLPNPVRFYMTNNATGCTSDLQTVTFYAGSPTALLETETDYVLCDADFDGITAFNLDSKKSEFTADSTAQFEYFKDAGLSQSIPSAYTNETPFAQTVYVRITVPGYCPSIANFHLDVNTPTKSTTLLETYFICFGDSATIDAGTENISWQWSTGETGQTVSISEAGNYSVILTNAEGCSYTHNFVVSDENQPKIDVINQTNNSIEVVARGGVQPYRYYFNGVPQNSSVLLNPTEPYYEIQVESATGCLGPPKTVYFIKINNAFTPNGDGKNDIWKVENLDKMESVSLVIVDRWGSKVFESADKTKIEWNGKSGGRALPGSTYWYTLTWFDAVTQKTEQRQGWILLKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W3</accession>
    <name>C6X4W3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic hydroperoxide resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01001"/>
    <dbReference type="EnsemblBacteria" id="ACU07451">
        <property type="protein sequence ID" value="ACU07451"/>
        <property type="gene ID" value="FIC_01001"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01001"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106355_2_1_10"/>
    <dbReference type="OMA" id="YSACFDS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="145" mass="15385" checksum="76C1475EC8AEC0C9" modified="2009-09-22" version="1">MKNKFMKTLYTTSVTATGGRDGHVQSQNGIIDMEVRTPKALGGKSDDFANPEMLFAAGYSACFDSALNLVIGKSKTQTGETSVTAEVSIGQIDNGGFGLAVKLDVNVPGVTQEEAQALVEKAHQICPYSNATRNNIEVTLNVTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W5</accession>
    <name>C6X4W5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxygen-insensitive NAD(P)H nitroreductase</fullName>
            <ecNumber evidence="3">1.5.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782599.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01003"/>
    <dbReference type="EnsemblBacteria" id="ACU07453">
        <property type="protein sequence ID" value="ACU07453"/>
        <property type="gene ID" value="FIC_01003"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01003"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_1_10"/>
    <dbReference type="OMA" id="FAAWDTY"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="210" mass="23739" checksum="B754AF14283CF43C" modified="2009-09-22" version="1">MALLENLNWRHAVKAYDPTKKVSGQDLNKILEAARLAPTSSGLQPFRVIVVENQDLKEQMVKGALNPEVMRDCSHVLVFAAWDSYSAEKIDKVYDYHTEVRDLPQGRFSSYTDQLKQIYGAQTADENFAHTARQTYIALGLAMAQAAELKIDSTPAEGFSTEVVDEILGLKELGLRSVTLLYLGYRDSENDWLSHMKKVRIPMDEFVIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z0</accession>
    <name>C6X4Z0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782624.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07478">
        <property type="protein sequence ID" value="ACU07478"/>
        <property type="gene ID" value="FIC_01028"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01028"/>
    <dbReference type="eggNOG" id="ENOG5033200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383352_0_0_10"/>
    <dbReference type="OrthoDB" id="1947951at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="184" mass="21380" checksum="42BB2DF909EF19E0" modified="2009-09-22" version="1">MWGPPLTPEVQFMTAKQKERIELKIAKIKKELAADKKRWGGYYDDSRGLRYLPPELYLRIHDYSGALRYFNWFSKNFPDDSGYPVFLFEWAIILFKNGRMKEAEAKTLKTDIANCWIIPAFLQITNTRPAAKAFSSWETPDIAEEMGYSKNDEELADFAAWLRDFVSSAEFTALRGELYKPAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X535</accession>
    <name>C6X535_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">cAMP-binding protein-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805808.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01073"/>
    <dbReference type="EnsemblBacteria" id="ACU07523">
        <property type="protein sequence ID" value="ACU07523"/>
        <property type="gene ID" value="FIC_01073"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01073"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_1_10"/>
    <dbReference type="OMA" id="EITRCFI"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="21474" checksum="D99F567448519821" modified="2009-09-22" version="1">MEAFTDYILQFGNLNRQQIDLIVGKAKETELRKDSYFSEAGKIPRQVGFVLEGVMRGCYYNNKGDEITRCFISENSLVVDYVNFEAHTASSEYLQASTDCNLVVFSKADWEDLSRTIVGWDPIKNKMVQQCLYQKSRKGPVISQDATTRYLEFLENYPTLANRVALSHIASYLGVTQQSLSRIRKNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X574</accession>
    <name>C6X574_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component transcriptional regulator, LytTR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01112"/>
    <dbReference type="EnsemblBacteria" id="ACU07562">
        <property type="protein sequence ID" value="ACU07562"/>
        <property type="gene ID" value="FIC_01112"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01112"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939253_0_0_10"/>
    <dbReference type="OMA" id="INIAAMI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="2">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="34971" checksum="714A3D6D48430FC7" modified="2009-09-22" version="1">MAEDGFRINNYIWRRLKSMNPSFFERFKSKSWLKHVVYWTVFVLFFGFVWGVSDHSYSRNMLIQVFCLPSRMVLVYVTLFYLFPMFFSKKKYFSFFISYCVLVALISVFIQRPLALYFIQPHFLPGFKNTGYFVLSEIMNTALDINIAAMIPLAYTYLTQFENLQRNNSELNEENRLLKQNATFKDDDKEYINFKIDKSIRKVRISEIVFVESLRNYCRIKLDASEFTVLKTLTSVQELLPGSQFVRIHRSFVVNKQHITSVSASRIEISDITVPVGRKYKEDVKRTLLTVESAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>C6X586</accession>
    <name>C6X586_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">kdpB</name>
        <name evidence="13" type="ordered locus">FIC_01124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805859.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01124"/>
    <dbReference type="EnsemblBacteria" id="ACU07574">
        <property type="protein sequence ID" value="ACU07574"/>
        <property type="gene ID" value="FIC_01124"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01124"/>
    <dbReference type="eggNOG" id="COG2216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_10"/>
    <dbReference type="OMA" id="ILWLWFT"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="670" mass="71872" checksum="C978F984733F6CF0" modified="2009-09-22" version="1">MKSDHPSLFQKELLNEALVQSFVKLNPKLMFRNPVMFTVEIGTAVMLAVTLWTLAGETSQGSFGYNFTVFFILLLTLLFANFAEAIAEARGKAQADSLRKTREETPARLENGEIISSSQLKKRDVFICEAGDLIATDGEIIEGLATIDESAITGESAPVIRESGGDKSSVTGGTKVLSDRIKVQVTTEPGESFLDKMIALVEGASRQKTPNEIALTILLAGFTLVFIIVTITLKPFADYANAPITIASFIALFVCLIPTTIGGLLSAIGIAGMDRALRANVITKSGKAVETAGDIDVLLLDKTGTITIGNRKATHFYPAEGISEKQLIRAGVLSSMSDATPEGKSIIELAGIDPQTYEVKSPRFIQFSAETRSSGIDFDNTRIRKGATDAIKNITEKAGHVFPAKTEERVWIISSNGGTPLVVAENEKVLGVIELQDIIKPGIQERFARLRKMGIKTVMVTGDNPLTAKFIAEKAGVDDFIAEAKPEDKMNYIKKEQAEGRLVAMMGDGTNDAPALAQADVGVAMNSGTQAAKEAGNMVDLDNDPTKLIEVVEIGKQLLMTRGTLTTFSIANDVAKYFAIIPALFITAIPALQSLNIMNLNSPESAILSAVIFNAVIIPFLIPLALKGVAYKPIGASALLRRNLFIYGLGGVVVPFIGIKIIDIVVSLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X595</accession>
    <name>C6X595_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01133"/>
    <dbReference type="EnsemblBacteria" id="ACU07583">
        <property type="protein sequence ID" value="ACU07583"/>
        <property type="gene ID" value="FIC_01133"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01133"/>
    <dbReference type="HOGENOM" id="CLU_151876_1_1_10"/>
    <dbReference type="OMA" id="TCICNCC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972325" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="106" mass="11733" checksum="F51C79E7FA2570D0" modified="2009-09-22" version="1">MKFLAFLLSVFFMVLTVVPCSDTANFFGDKTGVAEEVHLQQGQAGHADQCAPFCVCNCCGMSMTVTQIKKLLPEKNFLLVKAEITESTYNYSLLFNAGIWQPPKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F7</accession>
    <name>C6X5F7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01197"/>
    <dbReference type="EnsemblBacteria" id="ACU07645">
        <property type="protein sequence ID" value="ACU07645"/>
        <property type="gene ID" value="FIC_01197"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01197"/>
    <dbReference type="HOGENOM" id="CLU_1003813_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973720" evidence="1">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="277" mass="32296" checksum="B43DA441B7B14407" modified="2009-09-22" version="1">MKFRILVTAATLLCCSVHAQMREMNYLKESGTKGNVKSVKVIRQEVIDNSGKLTGYRDPTEMILEFDTSGNAVSAVMINGDVTEARQVRKYNSRNLKYEQENYHYGTDCGAVTKYEYDKKDNLTTVTYYNCDGTLRLTERMEYDLNNNLIFKSTNFGKTSDTSLKFKYDGRNNLIEQVLMNRTNGVEQKTTTTYTYDSSNVRKTKSTLDNNGSMTYHVRYEDADHYTAETYDDGKKSYERVYKTEKKNIDSVGNWTEEIYYRDGKAYERVTRYFTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G0</accession>
    <name>C6X5G0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PKD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805933.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01200"/>
    <dbReference type="EnsemblBacteria" id="ACU07648">
        <property type="protein sequence ID" value="ACU07648"/>
        <property type="gene ID" value="FIC_01200"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01200"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_273396_0_0_10"/>
    <dbReference type="OMA" id="YSYLWAP"/>
    <dbReference type="OrthoDB" id="256423at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025667">
        <property type="entry name" value="SprB_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13573">
        <property type="entry name" value="SprB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973615" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1177" mass="121160" checksum="41553B4838D28A0B" modified="2009-09-22" version="1">MTKIYIFLLSLIFAFSGLQAQTTETFETESVGSTSFTDNGQVFHISSQAPAIFDVFLYSGGGWNGTSVDNRFIDNSGTTYFNTPVEFTISTANQALFELKSIYLYLSKSDLGLSVSGSLTITGKRGGATVYSVSVNSPFNTSMGVNNGFTYINMANFGGVNNSSATIDQYVVKTTGNIAYVSLDAMTWKAACSPVTVAQASQTNVSCFGGSNGSATVTAANGPGLTYNWSPGNPPGDGTPSVTGLTAGNWTCTVTNACGNSNSVTISITEPQALTATQSQTNITCNGGNNGSATINVSGGAGSYTYSWAPFGGNAATASNLTAGSYTVTVTDANNCSTQRSFTITAPSALTATQSQTNITCSGGNNGSASVSVSGGAGTYTYAWAPFGGNAATASNLAAGNYTVTVTDANNCSIQRSFTITAPTAITATQSQTNITCSGGSNGSATINVSGGAGAYSYLWAPSGGTGATASNLTEGSYTVTVTDANNCSIQRNFTISAPPALTATQSQTNNNCSNSSTGSATVNVSGGAGEYSYLWAPSGGTGATASNLTAGTYTVTVTDANSCSIQRSFTITAPTALTATQSQTDVTCNNSNNGTATVAVSGGTGSYTYAWFPSGGNGPAATGLAPGFYIVFISDANGCSIQKQFTIGTATCSMVTWNGTGWSNTTGPDTSSVAIIDGDYSGPAFAALSLTVNAGKTLNVTDYVTTGDVTNNGHIIVADGANFVQTGTFTAGTDSSFKVRKSTKAVKRLAYINWSSPMNNSAQTLKEFSFGKNADGSNQSATGTVDNRFFTYNNNAFVSILPGSTFNPAGAGFLIRTPNDFTTTGQVFNGQFEGTTPNSGTISYDHSGIAGDYVMLGNPYPSAISLDDFLTANPGTTETVYIWNSQAVMDANNQYTGTNYNTYAPGTGSVPAGSINGFIPVGQAFFVERATMPTTTPFVFTDALRQITQDGVFSRGATADKFWLELTSPSGSKPQMLIGFNAAATAGFDAGFDAALIGSNADALYSTVDNRKLVIDAHGSFTSDDSFVLNADVSTAGSYTIGVLKTEGVFANGQQIWLKDQVTGSVTLISEQPYTFTAEAGSVTDRLTLQFKPGGALATDGAVKAGITIFSSGSEIHARAAEHISSVEVYEMSGKLIANARTSQKDVTVQVNYQGVVLVKVVLQNGTVQTKKLMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I3</accession>
    <name>C6X5I3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01223"/>
    <dbReference type="EnsemblBacteria" id="ACU07671">
        <property type="protein sequence ID" value="ACU07671"/>
        <property type="gene ID" value="FIC_01223"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01223"/>
    <dbReference type="HOGENOM" id="CLU_1123545_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="28505" checksum="94A3E1F030035D21" modified="2009-09-22" version="1">MTRSLTNMNYKDDSISLIEDAKNTLLEIKNSYAESLHEKEVKSKLLIKIKNFMENLRSALDFSSHYLFDKYGSSTVSNPKIYFPYAWGELDLAEFRRRNLIENKIPGLSSNRPDIAIAIEDFQHFSDEKNSWLPKFMDLNNENKHQRLTPQTRTEDKELNIKFDNGLTAISLSGGSIIHLAEGSTMEIGDSIIRGGQTFSAENPPIIENGNTQIITWVSFEFTDLNEPVLPFLEKALNGCEKIVIKMTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q8</accession>
    <name>C6X5Q8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01298"/>
    <dbReference type="EnsemblBacteria" id="ACU07746">
        <property type="protein sequence ID" value="ACU07746"/>
        <property type="gene ID" value="FIC_01298"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01298"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120358_1_0_10"/>
    <dbReference type="OMA" id="VHCREES"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="2">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="19237" checksum="AF5ADE4CFA41B264" modified="2009-09-22" version="1">MKIQAVFLYLLTLYKVSQLFGTIGVSVIIYKIRHMKQIIITKQDSTRIHKSIMDAKKNNSIKAEDAERLLRELHSAKIVESADIPADVVTMNSVVKIHFENNKTVTEFKIVYPEQANIKDRKISIFSPVAAALIGYSVNDEIDWIVPSGMTKIIIDEIIYQPEAAGDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T2</accession>
    <name>C6X5T2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01322"/>
    <dbReference type="EnsemblBacteria" id="ACU07770">
        <property type="protein sequence ID" value="ACU07770"/>
        <property type="gene ID" value="FIC_01322"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01322"/>
    <dbReference type="eggNOG" id="ENOG50310YZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281617_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="215" mass="24326" checksum="D186E8EFB66E1479" modified="2009-09-22" version="1">MHEARDIAGAIGVGVLFVTLFILLYRRHRMGQGGGYFLASVVALTAIEGYSTFQRATDKTYNTSPVYIIGIELVVFALLLFYFRKLLVRPVFRSISMAIILFFFIQYFLGAFLIDDFFTKLPFITYLLGVLCIAGSVILVLWQTFNSNEIFTLNNYFPFWVCVSTLIIFIGVLPLLVARYYAGLNANIFYTTLFLVHVLGHLATIIGILKAKPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U4</accession>
    <name>C6X5U4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ordered locus">FIC_01334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806067.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01334"/>
    <dbReference type="EnsemblBacteria" id="ACU07782">
        <property type="protein sequence ID" value="ACU07782"/>
        <property type="gene ID" value="FIC_01334"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01334"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_10"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="269" mass="29654" checksum="18EE0A2FD5EF5C1B" modified="2009-09-22" version="1">MIILKTLDELRLMRESAQLVSKTLGMLAREIIPGNTTAHLDKLGGEFIRDHGGEPAFLGMYGFPKNLCISPNAEVVHGIPNDKPLQEGDILSVDCGVYMNGFYGDHAYSFEVGEVAPETKKLLDVTKESLYKGIAQCVRGKRVGDISNAIQEHCEKHGYGVVRELVGHGLGRKMHEDPQVPNYGRKGSGKVLKDGIVLAIEPMVNLGTEKVKFHDDGWTVTSLDNSPSAHFEHDVTIINGKPVLLSTFRYIYEALGITSTEEDAFRLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U6</accession>
    <name>C6X5U6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ordered locus">FIC_01336</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806069.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01336"/>
    <dbReference type="EnsemblBacteria" id="ACU07784">
        <property type="protein sequence ID" value="ACU07784"/>
        <property type="gene ID" value="FIC_01336"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01336"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_3_10"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="192"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="291" mass="33891" checksum="77DB94416F3DC229" modified="2009-09-22" version="1">MHKAGFVNIVGKPNVGKSTLLNQLMGEKLAIVTQKAQTTRHRIFGIYNEEDLQIVFSDTPGVLDPKYGLQERMMDFVKDSLQDADVFLFIVDILDKSEPFEYLVDKLNKIPVPVLILVNKIDESNQEDLEKVMELWHERIPKAEILPISALKGFNTEIILPKLKSLLPENPPYYDKEMYTDKPERFFVNEAIREKILLNYEKEIPYSVEVVTEMFKENEGIIFIDSVIYVERDTQKGIIIGHKGEAIKKVGIEARIDLEKFFSKKIHLNLFVKVKKDWRKNDRDLKNFGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z4</accession>
    <name>C6X5Z4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ligA</name>
        <name evidence="12" type="ordered locus">FIC_01384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806117.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01384"/>
    <dbReference type="EnsemblBacteria" id="ACU07832">
        <property type="protein sequence ID" value="ACU07832"/>
        <property type="gene ID" value="FIC_01384"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01384"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_0_10"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="588"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="33"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="667" mass="75872" checksum="F6E94B99D87B740F" modified="2009-09-22" version="1">MPENIQQKIDALRKEIHQHNYSYYSLDEPTISDFEFDLKLKELQDLELQFPEFYDNNSPTLRVGGQITKNFPTVQHQFRMFSLDNSYDFNDLEEWEKRIRKTLNEPVEFVAELKYDGASISILYENGKLNEAVTRGDGFQGDEITSNVKTISQIPMQLHGDFPERFFMRGEIYLTHQNFEKINKRREEEGLDPFMNPRNTASGSLKMQDSGEVRKRGLSAVLYQFISENTAAQTHWELLQKAKSWGFRISDQAKLCADLDEVKAFINFWDENRHTLAFDIDGIVVKVNDLAQQRVLGYTAKSPRWAMAYKYKAEKAETELQTVTYQVGRTGAITPVANLKPVLLAGTVVKRASLHNEDIIRKLGLYEHDFVYVEKGGEIIPKIVGVNLAKRNPANAEIQYIKNCPECSTALIRVEDQAIHFCPNELHCPPQVIGRMIHYVSRKALNIENLGSETIEQLYREKLVENPADFYALTKEQLLPLERMAEKSAQNIITGIEKSKEIAFEKVLFGIGIKHVGETVAKKLVKNFNSIDDLKNATAAELVQVEDIGLKIAESITEFFKNPENVLMIERLKSYGVKLEKGADTHEVLSNALDGKTFLFTGKLSLFTRDDAEEMVEKHGGKNISAVSKNLDFLVVGEKAGSKLKKAQEIGTITILDEQQFLDLLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z6</accession>
    <name>C6X5Z6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806119.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01386"/>
    <dbReference type="EnsemblBacteria" id="ACU07834">
        <property type="protein sequence ID" value="ACU07834"/>
        <property type="gene ID" value="FIC_01386"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01386"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_4_1_10"/>
    <dbReference type="OMA" id="VNMRPPG"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="120"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="403" mass="45762" checksum="39EF3130A3FBB075" modified="2009-09-22" version="1">MAENTVVCIASYYKGYDFIDELHKLGNKIILITSENIKEKNWPWHAIDEVFYMHETEPSVWDLNHLVQGFSHLMISRKIDALVALDDYDVEKAAMVRETFRIPGMGQTTHRYFRDKLAMRQMAKDSGIDVPEFSSIFNDEVVQNFTAKVPAPWVLKPRSEASATGIIKINSTDELRAAIEKTGTERYRFLLESFKPGDVFHVDSLVYNREIVFTSASQYLSPPMQISHDGGVFRTKTLSRSSDEYKALHTANAKVLKSFGLVNGATHTEFIRGNADGKWYFLETSSRVGGAHIPDLVEASSGINLWREWARIENALLNHTEYQAPEPTDFFSGLIIALIKEQNVRQEEFECEEVLKFLPLDYHAAIVYKSESGAKIQQRLDEAAEKITGNYLNILPPRGKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X615</accession>
    <name>C6X615_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806138.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01405"/>
    <dbReference type="EnsemblBacteria" id="ACU07853">
        <property type="protein sequence ID" value="ACU07853"/>
        <property type="gene ID" value="FIC_01405"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01405"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030795_2_0_10"/>
    <dbReference type="OMA" id="ARRINWI"/>
    <dbReference type="OrthoDB" id="699908at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025291">
        <property type="entry name" value="DUF4153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13687">
        <property type="entry name" value="DUF4153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="594" mass="68919" checksum="08BB498E8F9418A9" modified="2009-09-22" version="1">MFQKIKLTFGKTDGAVREYPMMLLMALLAAVSLICYADGNYNSNPNYFVFIKFALVCCLGISLMFALKMLSQRIGQGILLEIAAVLFLIFFYFLLPEKERDFTEKYAFLIIPTFILSHLLVSFVAFTGKNKEIRFWQYNKNLFINIFLTAVFTGVLTGGAELAVLAIDKLFDFNFSDRLYAQLFYFLAIFGSCFIFLLFSEEGLKNLEKDGNYPIILKFFTQYILIPLLIIYAVILYFYAAKILINWELPRGWVSYMVLAYSLVGILALLLVHPLKQDSTKSWVKLFSRIFHFSLSPLLILLFTAIFTRILEYGYTEPRYFVLLLSLWLSTVVLYFIFAPKSTIKFIPMSLFTFGLFALTIPYLNTFSVAKRSQKTELQKVLQENNLLRNNHIDFTKKVSDTVADEVAGKFAFLMQRGDSAFLMNYLNKTDKTALAKQLTERNAYGLQNNLRFRFSNVVNTRRTPEYNRLEIVAESKVQKIAGYDYMIGFEDFYNDTNFKIGDDVFSISSRTGMPDMWLKIKLNNSETWEVTPFIRQMLSSNAQRNGRQEVPELMTERVLGKYHIKVFFNMISRENTNREQINFNGGYILIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X623</accession>
    <name>C6X623_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">General stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806146.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01413"/>
    <dbReference type="EnsemblBacteria" id="ACU07861">
        <property type="protein sequence ID" value="ACU07861"/>
        <property type="gene ID" value="FIC_01413"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01413"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153787_0_0_10"/>
    <dbReference type="OMA" id="KHSTRCS"/>
    <dbReference type="OrthoDB" id="1740395at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022551">
        <property type="entry name" value="BrxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11009">
        <property type="entry name" value="DUF2847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04019">
        <property type="entry name" value="B_thiol_YtxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="126" mass="14268" checksum="CDDCEEF5A34FEAA3" modified="2009-09-22" version="1">MSFLDKIFGKSEGEDSSVNFWKYIESETDLDNAIAESSDRKVAIFKHSTRCHISKMVLRNFEKEVSDCGDDVSYYFLDLIEHRNISNKIESMLGVVHQSPQLIVLQNGKAVKNASHQSISTALLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X626</accession>
    <name>C6X626_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase</fullName>
            <ecNumber evidence="2">3.5.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806149.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01416"/>
    <dbReference type="EnsemblBacteria" id="ACU07864">
        <property type="protein sequence ID" value="ACU07864"/>
        <property type="gene ID" value="FIC_01416"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01416"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_1_10"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="201" mass="22634" checksum="6F8E692ACF6ACBC5" modified="2009-09-22" version="1">MKKALIIVDVQNDFCEGGALAVPNANQIIPYINLLMEDNIYDQIVLTQDWHPANHKSFASNNGKKVGETIILNEIPQFMWPDHCVQDTFGAEFHKDLNIDKVTHIIQKGKNTDVDSYSAFQDNNHFVKTGLDDFLKYHEIQLLEVVGLALDYCVKFTCLDASQLGYITCLHFNGTRAVNVKPDNGKDAIYEMLQNSVTVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X631</accession>
    <name>C6X631_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01421"/>
    <dbReference type="EnsemblBacteria" id="ACU07869">
        <property type="protein sequence ID" value="ACU07869"/>
        <property type="gene ID" value="FIC_01421"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01421"/>
    <dbReference type="HOGENOM" id="CLU_3373898_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="34" mass="3710" checksum="87CFB605AED922F0" modified="2009-09-22" version="1">MEGAELPSGGAEFFAFLHEEWIKVVVYQPGAVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A0</accession>
    <name>C6X6A0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ordered locus">FIC_01491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01491"/>
    <dbReference type="EnsemblBacteria" id="ACU07938">
        <property type="protein sequence ID" value="ACU07938"/>
        <property type="gene ID" value="FIC_01491"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01491"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_10"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="260" mass="28468" checksum="8133B3724E0C7EB7" modified="2009-09-22" version="1">MINTDKMQFAASNIPKEKKLSIYFTAGVPELESTGEVLKLIQDAGAELVEIGMPYSDPVADGPVIQHAHERALKNGMTVAKLFEQLKKVKDEIKIPVILMGYINPVLTFGFENFCSECADSGVSGLIIPDVPPIEFEKNCRAVLKKYNLTFTFLVTPETSDERILYLDSLSSGFLYAVSSSSTTGNATKDVNNEGYLTRLAELNLKNPVMIGFGIKNKADFSKVTAKAAGGIIGTAFVNILLSDEDWRTASRNFIQKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB2</accession>
    <name>C6WZB2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00522"/>
    <dbReference type="EnsemblBacteria" id="ACU06980">
        <property type="protein sequence ID" value="ACU06980"/>
        <property type="gene ID" value="FIC_00522"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00522"/>
    <dbReference type="HOGENOM" id="CLU_3200104_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="45" mass="5003" checksum="04BE3227B4CE5165" modified="2009-09-22" version="1">MQRKSFLVAEAAEATKKDCSVKPVVSPQQRKSSGSLNKILKQKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD9</accession>
    <name>C6WZD9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-(Acyl-carrier-protein) synthase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782117.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00512"/>
    <dbReference type="EnsemblBacteria" id="ACU06970">
        <property type="protein sequence ID" value="ACU06970"/>
        <property type="gene ID" value="FIC_00512"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00512"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_4_1_10"/>
    <dbReference type="OMA" id="LFGCPGW"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="129"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="255"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="355" mass="39780" checksum="501B2B377C315FCF" modified="2009-09-22" version="1">MPNTIIIGSGSYIPTKVIGREHFKDSVFYTDEGDKIDKPVEEIIQKFVEITEIENRRYLEDDEFNSDLGHRAAQKAIEDAGIDPEELDYIIYASNFGEVDRNGMTNFMPSMSARVKNKLGILNRKCVNYDMIFGCPGWVEALIMADTLIKSKKAKLILVVGSETLSRVTDAFDRNKMIFADGAGAVVVTATDDENVGIIADSTICDNHAELDYLENAPSLKLDEDRRPLYIRMHGRKIYEYALKNVPIAVKETIDKAGLSIDDIDKILIHQANAKMDYAMISRLFKLYGITDYDHDIAPMTIQQYGNSSVATIPTMFDMIRKGEMAGHTFKEKGIILFASVGAGMNINAVVYRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE3</accession>
    <name>C6WZE3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782124.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00519"/>
    <dbReference type="EnsemblBacteria" id="ACU06977">
        <property type="protein sequence ID" value="ACU06977"/>
        <property type="gene ID" value="FIC_00519"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00519"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_3_0_10"/>
    <dbReference type="OMA" id="LILEHYT"/>
    <dbReference type="OrthoDB" id="1606021at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="118" mass="14015" checksum="EA168C797A3FF357" modified="2009-09-22" version="1">MKKVFYLKTCDTCLKILKKYSLKDWELREIKINPVTEEEIEEMYKLAGSYEALFSKKSNQIKLREIDPKSLGEEDYKELILDHYTFLKRPVFMTDKEIFIGSEKKTVEALRGYFAEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE6</accession>
    <name>C6WZE6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781628.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00003"/>
    <dbReference type="EnsemblBacteria" id="ACU06481">
        <property type="protein sequence ID" value="ACU06481"/>
        <property type="gene ID" value="FIC_00003"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00003"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081564_0_0_10"/>
    <dbReference type="OMA" id="FMIGPVF"/>
    <dbReference type="OrthoDB" id="1953934at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="25782" checksum="EF9A389BA26A7F6D" modified="2009-09-22" version="1">MIELILSAVGLGIMLSLVFIGPIFFLLIETSFCRGPKHAIALDFGVIVADILCIAAAFFASGDLVQIIDKHPGFYRITAFIILIYAVYMIVSKTKMHLPGEEKLIGQNYFKTFLNGFFFNILNIGVVLFWLVTVISVRNAYPKLDDFMLYMALVVSTYLVIDFLKIYLAKQFHYKLTDKLATQIRKGVGYILIVFSIFIFLQSFKKFNQFDRQLEEAEQTQQKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP1</accession>
    <name>C6WZP1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781723.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00101"/>
    <dbReference type="EnsemblBacteria" id="ACU06576">
        <property type="protein sequence ID" value="ACU06576"/>
        <property type="gene ID" value="FIC_00101"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00101"/>
    <dbReference type="eggNOG" id="ENOG5030MZ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125324_2_0_10"/>
    <dbReference type="OMA" id="YINPYLY"/>
    <dbReference type="OrthoDB" id="1714149at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="168" mass="19784" checksum="E5BF644E0090CE67" modified="2009-09-22" version="1">MISRTLFTDILMIVLLIALQIFVLNRITLFGKYTPVLYPVFVMFYPFFRNKYQFLALSFLLGLGIDAFLYTWGINAFATTVIAYFRTLIFRTSTDTSTDFFSFQSLQWSQYLFFILSSIFLHQLLMQYIEFFKLSRSLEIMLNVLATSAISFIFILMYALAFKIKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP5</accession>
    <name>C6WZP5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase type III, GlnN</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00105"/>
    <dbReference type="EnsemblBacteria" id="ACU06580">
        <property type="protein sequence ID" value="ACU06580"/>
        <property type="gene ID" value="FIC_00105"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00105"/>
    <dbReference type="eggNOG" id="COG3968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024307_0_0_10"/>
    <dbReference type="OMA" id="QFLVFCA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="213"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="752" mass="84760" checksum="558B3F45DB1A1F50" modified="2009-09-22" version="1">MSKIIFLYFYPHKYHNSMSHLRFKALETLSFKNFRQDNAVTVPAKLSELFCSNVFSEETMREYLTKEAFGSILDAIRKGAKIQRHIADQVAVAMKDWALSKGATHYTHWFQPLTGSTAEKHDSFFTPIEGGGGRAIERFSGGMLIQQEPDASSFPNGGIRNTFEARGYTAWDPTSPAFIMGTTLCIPSIFISYTGETLDYKAPLLRALNAVDEAATDVCRSYFDKNVTKVTPTLGWEQEYFLVDSALYQSRPDLVITGKTLLGHSPAKGQQLDDHYFGSIPTRVMNFMKELEIESMKLGIPVTTRHNEVAPNQFELAPMFEEVNVAVDHNSLLMDIMARVAHKHHFHILFHEKPFAGVNGSGKHNNWSLATDTGENLLSPGRNPKKNLQFLTFFVNTLKAVHDYADLLRASIASASNDHRLGANEAPPAIISAFIGTQLFAVLEELEKVTDGKLSPEEKTELKLNVVGKIPEILLDNTDRNRTSPFAFTGNKFEIRAVGSSANCAEVMTVMNSIMAKQLQTFKQEVDELIADKGLKKDEAIFNILREYIKVSKNIMFEGDGYSDDWAMEAEKRGLQNLKTTPEALARELDPRFVELYEDLGIYTHREIEARNEVKLEKYSTVIAIEATVLADIARNHIIPCALNYQNRLIENVKGLKEIFGDTEFRKLAKEQMNMITQISEHVSVIKVESENLLEAIATAKGAEHSQQIAEAFCNDVKPYFDVIRNSSDALEMLVDDELWPMTKYRELLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU5</accession>
    <name>C6WZU5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00155"/>
    <dbReference type="EnsemblBacteria" id="ACU06630">
        <property type="protein sequence ID" value="ACU06630"/>
        <property type="gene ID" value="FIC_00155"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00155"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_10"/>
    <dbReference type="OMA" id="PHIAWAY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="106"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="312" mass="35510" checksum="33E74C49DEBE8AB0" modified="2009-09-22" version="1">MMKILQLDKNHPLIVQQLAARGFRIDEDFSSSYDEILNKIENYDGIILRSRIPIDRRFIEHAKNLKFIARVGAGLENIDVEFAERNNIRVISSPEGNRDAVAEHVLGMLLILMHRLLISSHEVKNGIWRREENRGDELLGKTFGIIGYGNMGRAVAKRLSGFGVKVIFYDILPNLSDEFAEQVSLHTLQNEADVLSLHLPEAPQTRHFINEEFISSMKKDFYFINTARGKNVLTADLITYLKSGKIKGACLDVLEYEKASFEKIETENQDLKYLLSCEKVIITPHIAGWTTQSKEKLAQVIVDKIIAAFPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV1</accession>
    <name>C6WZV1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781783.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06636">
        <property type="protein sequence ID" value="ACU06636"/>
        <property type="gene ID" value="FIC_00161"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00161"/>
    <dbReference type="eggNOG" id="COG4640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140587_4_0_10"/>
    <dbReference type="OMA" id="MWSAIAG"/>
    <dbReference type="OrthoDB" id="2046989at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="103" mass="10636" checksum="9A12143BC1CA084F" modified="2009-09-22" version="1">MEFKNENPGFSSGPTGFPPKNWLVESILVTLFCCLPLGIVGIINAASVEGKYAQGDTDGAQRAAQTAKTMVLVSAIVGVLGVLLYILFFGGLALVGAAAEGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X020</accession>
    <name>C6X020_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,4-dienoyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.3.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.34" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781852.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00231"/>
    <dbReference type="EnsemblBacteria" id="ACU06705">
        <property type="protein sequence ID" value="ACU06705"/>
        <property type="gene ID" value="FIC_00231"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00231"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_10"/>
    <dbReference type="OMA" id="FPTKGAW"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="292" mass="32127" checksum="99780C7A85020D0C" modified="2009-09-22" version="1">MKYTEPMLREDALKDKVAIVTGGGSGLGKAMTKYFLQLGAKVVITSRNLEKLQATAKELEDETGGKVLCVQCDVRNWDEVEAMKDAAVKEFGQIDILLNNAAGNFISPTERLTHSAFDSILDIVLKGTKNCTLSVGKYWIDNKISGTVLNIVTTYAWTGSAYVVPSACAKAGVLAMTRSLAVEWAKYGIRFNAIAPGPFPTKGAWDRLLPGDLQEKFDMRKKVPLRRVGEHQELANLAAYLVSDYSAYMNGEVVTIDGGEWLQGAGEFNMLEEIPQEMWDMLEAMIKAKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X036</accession>
    <name>C6X036_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781868.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00248"/>
    <dbReference type="EnsemblBacteria" id="ACU06721">
        <property type="protein sequence ID" value="ACU06721"/>
        <property type="gene ID" value="FIC_00248"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00248"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OMA" id="ESWGPRY"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973286" evidence="5">
        <location>
            <begin position="23"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="45"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="526"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="973" mass="107696" checksum="062416ABDBC28272" modified="2009-09-22" version="1">MKKLTTSVLAVVLTSSFALVNAQVDTARTQDIEGVVVTALGIKRDKKSIGYAAQQVSGETLSEAGQSNALSALSGNVAGVQVTSPSSMGGSTRIVMRGVSSIIGENRPLIVVDGVPLDNSNVNDTNTQRGAGGRDYGDASFDINPDDVESVTVLKGGPAAALYGSRASNGVIIYTTKQAKRGKASVEFSTGIAFEEIYIRPKLQNYYGGGSSLTLPTQVINGQTYNLNEYKMDESWGPRYNPNLMYLPWYAFDQAEFPNDYMKQVAWVAPQHDVDSFFDTGITLSNNIAVSKSFEKSNIRLSYTNTAITGIVPTSKIDRHNFSINANSELSEKLKVETGINFVQTHGFNRPEQGYGDNSVAQKFYQWGQRQLDFSKMKDYKLSNGMQRSWNRTAWDDGVPYYSDNPYWTINENVSNDRRNRFYGFAGMTYNILPNLYATGKVYADIYSQDNDNRVAIGSQAVSGFSVFKRNFTEFNYEGRVHWNPEISDSWSLQAFVGANRRNVKRSDLNGATRGGLVIPNFYNLKNSINDPLATNSDYEKRVNSAFASVSLGFKETVFIEATGRNDWFSTTKEDKFYPSITGSFVFSNVLDANWLSFGKLRAGWASVASDTDPYQLANYSVQFTNFNNIPRYGLFTQNNNPDLKAELKETKEIGLEMNFLKNRLGFDVTYYDVSITDAILPLSVDPATGFRNNLINAGEITNKGIEAMVFVTPIKTEDFTWSLNWNFAKNENKIVKLYEGVSTYQLTNAPFQARLLAVEGESYGAIYGTDFTYDSNGNKVIGEDGIYIPTAIKNLGSTLPEYNMGLRNSLRYKDLSLSFLFDMQQGGKYFSTSHMWGMYSGMLEETGFGGNREAGTVLEGVLENGTVNNINISANEFGGMHYAGVDALNVFDASYIKLRDVTLSYDLPKSLVAGFLDGVRISAFGRNLLAWNLAWKGMDPENTSYGSGNIQGLEGGSLPSTRQYGVNVNFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X037</accession>
    <name>C6X037_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ordered locus">FIC_00249</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00249"/>
    <dbReference type="EnsemblBacteria" id="ACU06722">
        <property type="protein sequence ID" value="ACU06722"/>
        <property type="gene ID" value="FIC_00249"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00249"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_3_1_10"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="26"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU06722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="218" mass="24939" checksum="1A3F939900B6B45F" modified="2009-09-22" version="1">MAQITIKTSDSNMELKKKWSANYIEAGCDEVGRGCLCGPVVAAAVILDEKFVQNLVDDSKKLNFKTRIYLDAYIKDNVKEYAVAELPPSHIDEHNILNASIHAMHRALDQLQTRPELILVDGNRFHPYNFIPHQCIIKGDASILSIACASILAKNYRDQLMIKLHDEFPHYGWKTNMGYATKEHREALNRYGPTEHHRRSFRLDYSDQALEDLILAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X081</accession>
    <name>C6X081_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferrochelatase</fullName>
            <ecNumber evidence="6">4.99.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemH</name>
        <name evidence="8" type="ordered locus">FIC_00299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781913.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00299"/>
    <dbReference type="EnsemblBacteria" id="ACU06766">
        <property type="protein sequence ID" value="ACU06766"/>
        <property type="gene ID" value="FIC_00299"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00299"/>
    <dbReference type="eggNOG" id="COG0276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_0_1_10"/>
    <dbReference type="OMA" id="FSYHGVP"/>
    <dbReference type="OrthoDB" id="780534at2"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="340" mass="39428" checksum="1890A5F449249213" modified="2009-09-22" version="1">MKGILLVNLGSPRSTSVEDVKEYLDEFLMDEKVIDYRWFFRSLLVQGVILRTRPAKSAEAYKTVWTDEGSPLIVITKQIQQKLQKLIDIPVEIGMRYAEPSIETGIRNLTEQGVTEIVLFPLYPQYAMSTTETVIDKAEEVRKKHFPGIKINYVQPFYNREIYINCLAESIREKLPENYDALQFSYHGVPERHIYKTDPTNTCNLNDCCSRESNPSHQFCYRHQCFKTTEKVIEKLNIPREKTLVTFQSRLGKDKWMEPYTDETLENLPKKGVKNLAIVCPAFVSDCLETLEEISVEGKGEFLHAGGENFHYIPCLNDEDRWIDVVKTLCEEKLGEFYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A1</accession>
    <name>C6X0A1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06786">
        <property type="protein sequence ID" value="ACU06786"/>
        <property type="gene ID" value="FIC_00319"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00319"/>
    <dbReference type="HOGENOM" id="CLU_3251861_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="42" mass="4900" checksum="D606726AC5EA89B4" modified="2009-09-22" version="1">MHLARGLLRVDADAEYKQEEYDKLFHDELFNGKASGFIPSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A9</accession>
    <name>C6X0A9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide export outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00327"/>
    <dbReference type="EnsemblBacteria" id="ACU06794">
        <property type="protein sequence ID" value="ACU06794"/>
        <property type="gene ID" value="FIC_00327"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00327"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038343_1_0_10"/>
    <dbReference type="OMA" id="TTIWFSV"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="291" mass="32876" checksum="37ED9F3A636F358D" modified="2009-09-22" version="1">MMEGATKHRSTNPFFYLPLRLLIFLMKKHTSLLSLLLFLLAITSCKPKENMIYMESDRSATEEQVRQAVYEGSHLQSGDFLDIKVTAYDEFAVRPFNLHSMNQLTNPSESGGAQSAQAAPQGYLVDNEGYIIFPVLGKISVRGLTLAQLRQELENRLTEYLSDPLVSIRQLNFNITVLGEVKRPGQYTTPNDKVTLLQALGMAGDMTDYGDRTKVKLVRHENGTDKTVIIDFTDKNITSSPYYYMQQNDVLYIEPDIVRRRSANVDPNRALVFQIGGLALGIISILLTFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B2</accession>
    <name>C6X0B2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-glucose dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00330"/>
    <dbReference type="EnsemblBacteria" id="ACU06797">
        <property type="protein sequence ID" value="ACU06797"/>
        <property type="gene ID" value="FIC_00330"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00330"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_1_10"/>
    <dbReference type="OMA" id="GHCLPID"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="375"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="478" mass="52104" checksum="F49326304E0BA6D5" modified="2009-09-22" version="1">MNHKIAIIGLGYVGLPLARLFATKFPVVGFDINATRVAELNAGHDDTLEVSDELLQSALVSENPFVIGSSLQHGEFQKNAGDSQYVLLEEEHRIVKSTEADSTETLTADTVSPAIQSQTAGLYCSTDIADIAGANIYIITVPTPVDKNNRPVLTPLIKASETVGKVLKKGDIVIYESTVYPGATEEDCIPVVEKTSGLTYNVDFYAGYSPERINPGDKEHTVEKILKVTSGSTPEIGQIVNNIYKAVITAGTHLAPAIKVAEAAKVIENSQRDINIAFVNELAKIFNLMNINTHDVLEAAGTKWNFLPFKPGLVGGHCIGVDPYYLAQKAQEYGYHPEIILAGRRLNDSMGDYVASQVIKTMIKKGIKVNSAEILMLGITFKENCPDVRNTKIVDVIAALKDYSVNVTVYDPWANPAEVMHEYGLRCNTILDNDPKFDAIVLGVAHEEFLTLDLSLHLKPEGIVYDVKGVLTESDCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B4</accession>
    <name>C6X0B4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable succinoglycan transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781946.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00332"/>
    <dbReference type="EnsemblBacteria" id="ACU06799">
        <property type="protein sequence ID" value="ACU06799"/>
        <property type="gene ID" value="FIC_00332"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00332"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026911_2_0_10"/>
    <dbReference type="OMA" id="HRYHNPL"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="492" mass="55542" checksum="F5D3493916D950BF" modified="2009-09-22" version="1">MRGFSNSLNTKYLRKISDLKNESVSGGMWSMLGQVINFSVQILGTMVLARVLFPEDYGLIAVVGTFTGFVAVFRDMGLTTATIQADNLDDSLFSNIFFINLFVGLLLTIIFASTAPLVQWFYNDDRLLLVTIVSAFQFFLGSLSAQLLALLKRSMNFKIIFITQLISSVSGVVFSVFAAYLGFGYWALVIGPLFSSWFLFIYLFFLFRWIPNKPVWDPRIKSILHFGKHITTFEVVNYLSRNLDNILIAKFFGIASLGIYNKAYTLLMMPINQIRSPLMNVALPALSTLKNENLKFSNYYLNFISVLTVLSNIIILLLIINSKEVVHIVLGPNWSESAKIFAILGIAALVQPIYGTFSLVLISLGKSKKYSTWGTYNAMIIVPSFIIGINFNLEIFAVCYVVANFITFFFSAFYVFLDSPVPVWAFFKRTVPIIAIFSLFAVITYFTAHVDGNIILSFFLKSILFTTLSVAYLVLFYKEKNILIGVIKTFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D2</accession>
    <name>C6X0D2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase RfbO, CysE/LacA/LpxA/NodL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781964.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00350"/>
    <dbReference type="EnsemblBacteria" id="ACU06817">
        <property type="protein sequence ID" value="ACU06817"/>
        <property type="gene ID" value="FIC_00350"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00350"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_8_1_10"/>
    <dbReference type="OMA" id="IDDFCVL"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="194" mass="21014" checksum="2C2F61D330CF6A34" modified="2009-09-22" version="1">MAYLSQDEINKIGFAQVGHDVFISDKASFHNPAKISIGSFVRIDDFCLLSAGEDGIEIGNYVHISCYACLIGKGLIKLHDYVLISIKATILSSNSDFSGQFAPALKEFDTLDKPYATVFSEAVTFETHTGLGAHSVVLPGVTVGEGTAVGAMSVVYQSLNPWGIYLGNPARFATKRSKRVYKILEDLKESQADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E2</accession>
    <name>C6X0E2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00360"/>
    <dbReference type="EnsemblBacteria" id="ACU06827">
        <property type="protein sequence ID" value="ACU06827"/>
        <property type="gene ID" value="FIC_00360"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00360"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_6_1_10"/>
    <dbReference type="OMA" id="GRENDMT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="227" mass="25151" checksum="537689C7248443DA" modified="2009-09-22" version="1">MIEAVKDTCNIYIMKNSGVRTFLIKIIRLNLKTLLINWFTKGNRKNNLIIVKSKFTSFIHHNAEINLNKGNLILNDTMRVSEPFVGMLEMQNNSTINVQGEFIVNSGMHIIVLDNAKLNLGSGYINRNVKIRCSNEITIGKNVAISENVTIWDSDGHAIIGRENDMTKPVFIGNHVWIGNNVTILKGVQIGDNSVIAAGSVVIKDIPANCLAGGTPAKILKQDINWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J7</accession>
    <name>C6X0J7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782030.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00416"/>
    <dbReference type="EnsemblBacteria" id="ACU06883">
        <property type="protein sequence ID" value="ACU06883"/>
        <property type="gene ID" value="FIC_00416"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00416"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_0_0_10"/>
    <dbReference type="OMA" id="DENRTMT"/>
    <dbReference type="OrthoDB" id="1537812at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="191" mass="21060" checksum="11350642832639B0" modified="2009-09-22" version="1">MAEVQVKDNSGKGGKVRSKKSVPHVDLTPMVDLAFLLITFFMLVTTFNKPNVMDLGLPAKPKDNVKPPDTEIDLTNSISLIIGKDNRIFYHQLTAADLNDQTLQETTFDRNGITKVIEQAKARAKDQAKFTVIIKPTDDAIYKNFVDMLDEMAITKNEIYGITDVKSWEQAVYDKKVGGSAAPAAPAADTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J8</accession>
    <name>C6X0J8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782031.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00417"/>
    <dbReference type="EnsemblBacteria" id="ACU06884">
        <property type="protein sequence ID" value="ACU06884"/>
        <property type="gene ID" value="FIC_00417"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00417"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065795_0_0_10"/>
    <dbReference type="OMA" id="PTQARRM"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="3">
        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="279" mass="30843" checksum="C83B5F4A1387071D" modified="2009-09-22" version="1">MAEDTTYKSNLTLDEIVFENRNKAYGAYDLRTTYRSVLTKAFIIGTVLFLVGAITPFVIMKIQEMNAREAVEVDANLIDILPEEEQIIEQPKDEPPPPPPPPKEEPKIEIIQNVVPEPVKAPKVETPPPPISRQLETTTGVVAQEGVKAPAYTPPPPPPGPSKSTTVEVKPQVSETQVYTEVEQLAEFPGGINSFRSKVNSSFDTSVMDGDEGTVKTEVTFVVERDGSITDVKASGSNRDFNAEAIRTVKSIKNKWAPAKINGQAVRYRFRMPLTMQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K4</accession>
    <name>C6X0K4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782037.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00428"/>
    <dbReference type="EnsemblBacteria" id="ACU06890">
        <property type="protein sequence ID" value="ACU06890"/>
        <property type="gene ID" value="FIC_00428"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00428"/>
    <dbReference type="eggNOG" id="ENOG50347H1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1508471_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="178" mass="20182" checksum="99C92FFDFA44B80A" modified="2009-09-22" version="1">MRTKLILPALMLAQLLCGQTSDLAAKLLQKEQEVRDLSLQVKYYKTVLNSTRAIRSATFENIRFDLTQVTGSRKDGSLVIGFSYNNVGDTRKTLQCERALLVDMQGNQHQTTLINLAPNGKVIAFDVLPKVPYRGAIIYKKLNYYFPVIRSLVLYIYPKDNISNPSPVVFENVPVIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0W5</accession>
    <name>C6X0W5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806363.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01633"/>
    <dbReference type="EnsemblBacteria" id="ACU08078">
        <property type="protein sequence ID" value="ACU08078"/>
        <property type="gene ID" value="FIC_01633"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01633"/>
    <dbReference type="eggNOG" id="ENOG502Z8AC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064308_1_0_10"/>
    <dbReference type="OMA" id="FRLVAEW"/>
    <dbReference type="OrthoDB" id="1630081at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025737">
        <property type="entry name" value="Phenol_MetA_deg_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13557">
        <property type="entry name" value="Phenol_MetA_deg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973457" evidence="1">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="248" mass="27679" checksum="5FCB05B395915099" modified="2009-09-22" version="1">MRKFTLILLVHLFSSITAQETIETDRPDQTETPSVTPAGFLQIETGFLYEKVRDGAKSASHRTVLWRYGLNDRFEMRMVTELNSEQFGDDLRTGLAPIVFGFKAKLIQKKEMMPAVSFVGHLAAGNLASPVMQTVNWAPSFRFLIEHSLGEKLGLSYNLGAEWNGETPDATSIYTIAASYAFTPQLSMFAEFYGFLNKHSTADHRFDSGFTYLLNNNLMLDASAGVGLSEVSPNYFLSGGVSYRFPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y2</accession>
    <name>C6X0Y2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01651"/>
    <dbReference type="EnsemblBacteria" id="ACU08095">
        <property type="protein sequence ID" value="ACU08095"/>
        <property type="gene ID" value="FIC_01651"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01651"/>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019348_2_1_10"/>
    <dbReference type="OMA" id="PMVSDIH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970528" evidence="1">
        <location>
            <begin position="36"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="386"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="695" mass="74088" checksum="9FED3475EAF497C0" modified="2009-09-22" version="1">MVFVTLRSKIFILNQMKKLTTLLLGFLFSMAVAQAPPTYYNGTDGLTGAALKSKLSQIISAGASDRGYDGLYTGYPTTDSDHFYENDGTVLDMYSENPAGTDPYTYRHGQKRCGNYSVEGDCYNREHVIPQSFFKSRAPMVSDIHHIRPTDGKVNGMRSNYPFGAVANPSYTSKNGSKVGPSSSPGYGGTVFEPIDEFKGDIARMVFYFVTRYESQLSGFSAGNMLGGSSYPGLQLWERDVLLAWSALDPVSPTEIERNNASYVFQNNRNPYIDRPEWVQQVWGTQVIDTQAPSAPANLVLSSTTTAAANLTWSASTDNIGVAYYKIYVNGQFHSNSNTTTATVSGLTQGTAYNFYVVATDAAGNVSAPSNTVTGTTLTDTVAPTAPVNLSVTSVGTNNIAVQWVAATDNIGVATYDIYVNGDLVGSSSATSTNIANLAPATAYSIYILAKDAAGNVSAPSNTVTATTAAVGVDCGNENFDSIPASSPNYSTYNWTSNGISWTSEDSRTDQTINGKALTIRNGFLTALSVPNGIGDLTVTTQLKFSGSPGTLQILVNGVDTGKTVPYSSTATTTTVTGINISGTVEITLQNNSTTNRVAIDNMKWTCYTVAGVNDSAADKNALSIYPNPVKNGELNVKGNNLNKIEVAQIFEFTGKLVQTVAQPFKNSTTIKLKNLPGGVYILKAGNSSTKFIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y6</accession>
    <name>C6X0Y6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">FIC_01655</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806384.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01655"/>
    <dbReference type="EnsemblBacteria" id="ACU08099">
        <property type="protein sequence ID" value="ACU08099"/>
        <property type="gene ID" value="FIC_01655"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01655"/>
    <dbReference type="eggNOG" id="COG0117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_1_1_10"/>
    <dbReference type="OMA" id="PYIILKW"/>
    <dbReference type="OrthoDB" id="1775351at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU08099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="342" mass="38372" checksum="3A570EEE5E8DFFDE" modified="2009-09-22" version="1">MTDELYMKRCIELAKKALGQTYPNPMVGSVIVHDGRIIGEGFHQKAGSPHAEINAINSVKDPSLLRDSTIYVSLEPCAHFGKTPPCADKLAEIGFKKVVIGILDSHDKVNGKGKQILENAGIEVVTDVLRNECFDLNKRFFAFQEKKRPFILLKWAESADRFIDKDFGPTQIGNALTKQYVHTLRSEEHAILVGTNTALTDNPSLTVREISGRNPVRILVDFDLKVPTSFNIYNSEAPTLVFNGVKNSVEGHISFIKISKDNFPATLMSQLYEKQIQSVIVEGGRFTLQQFIDTDLWDETVIIRNENINLTNGTKAPDFTAEASETQIFRDNTVEFYKNKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D2</accession>
    <name>C6X1D2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane lipoprotein (Lipocalin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01802"/>
    <dbReference type="EnsemblBacteria" id="ACU08245">
        <property type="protein sequence ID" value="ACU08245"/>
        <property type="gene ID" value="FIC_01802"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01802"/>
    <dbReference type="eggNOG" id="COG3040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068449_3_0_10"/>
    <dbReference type="OMA" id="YSCTTIV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002446">
        <property type="entry name" value="Lipocalin_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01171">
        <property type="entry name" value="BCTLIPOCALIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocln_cytosolic_FA-bd_dom" evidence="4">
        <location>
            <begin position="47"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036893-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="21237" checksum="66D836BA880A07C0" modified="2009-09-22" version="1">MLSAKINHMNTLTRTILPLSVGILGVLILNSCSAGIPKGATAVQNFNADKYLGKWYEIARLDFRFEKNLNNVTAEYSTKDNGHIKVDNQGYDYVKKEQKQSVGEARFRGSENVGELKVSFFKPIWAGYNVIDIDEDYRYALVAGDSLKNLWILSREKTVPEDIKQRFLQKAKSIGYNTADLVWVKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E7</accession>
    <name>C6X1E7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806545.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01817"/>
    <dbReference type="EnsemblBacteria" id="ACU08260">
        <property type="protein sequence ID" value="ACU08260"/>
        <property type="gene ID" value="FIC_01817"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01817"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="230" mass="25575" checksum="F11D2C04837BC7CF" modified="2009-09-22" version="1">MLLIKDLHKSYDTGKSKLHVLKGINLTIDEGEFVSIMGSSGSGKSTLLNIIGILDEKDSGIYDLDGIAIEELSEIKAAEYRSRFLGFIFQSFNLIGYKNALENVALPLYYQNVSRKERNKKALEYLEKVGLAEWANHLPNELSGGQKQRVAIARALITDPKVILADEPTGALDSKTTYDIMKLLQEINREGKTIIVVTHEPDVAAQTKRNVILKDGIIESDEFIAQKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H0</accession>
    <name>C6X1H0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ordered locus">FIC_01840</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01840"/>
    <dbReference type="EnsemblBacteria" id="ACU08283">
        <property type="protein sequence ID" value="ACU08283"/>
        <property type="gene ID" value="FIC_01840"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01840"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_10"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="156"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU08283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="248" mass="28097" checksum="C7BF76320A54310D" modified="2009-09-22" version="1">MELPQQRFFAASDYYPKQKEPNRAMRIDIISVLPELMESPFKTSILKRAVDKGLAEIHFHHLRNYGLGKQRQIDDAPYGGSAGMVMMVEPLDQCISDLKMQRDYDEVIYLTPDGETLNQKTANTLSTRKNLILLCGHYKGIDHRVREMHITKEISIGDYVLTGGELAACVLADSVIRLLPGVLNDEQSALTDSFQDNLLSPPVYTRPANYKGLQVPEILLSGNFAKIEDWLHDEAVKITREKRPDLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I1</accession>
    <name>C6X1I1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806579.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01851"/>
    <dbReference type="EnsemblBacteria" id="ACU08294">
        <property type="protein sequence ID" value="ACU08294"/>
        <property type="gene ID" value="FIC_01851"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01851"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054927_2_0_10"/>
    <dbReference type="OMA" id="WNVTARY"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="78"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="287" mass="33244" checksum="55DEC8E03B411064" modified="2009-09-22" version="1">MEIKDIIKKVKQIEIRTKKKSEATLMGQYHSAFKGQGMTFSEVRPYQFGDEIRRIDWNKTARFREPFVKVMEEERELTMMLLVDISASMDYGTRTQLKREFVAEIAASVGFSAAGNNDKVGLILFADKVYKVIPPQKGRKHILAIISTILTADYVPGVAKIDAALEYMMSVFKKKSMVFMFSDFQDEYSLKILRVASRKHSLLGMRIFDDKDSDIPDVGYSLFEDAETGKQIWANTANARWRYEYAEKQKQKLKSVEEDFESSAAGFMSINTDEDYSKFLYKYFRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K3</accession>
    <name>C6X1K3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806601.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01873"/>
    <dbReference type="EnsemblBacteria" id="ACU08316">
        <property type="protein sequence ID" value="ACU08316"/>
        <property type="gene ID" value="FIC_01873"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01873"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_10"/>
    <dbReference type="OMA" id="IPRFHAG"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="85"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="304" mass="33784" checksum="824749C8C3535DB7" modified="2009-09-22" version="1">MERFSTVAFLMCFSLVCAQIPRDSSFTDYSEQLKVRKKFPEAKLVSPVAANSVAVIENRVFTVVGKRELKLDAYLHKSVDKKPPVILIHGGGWKSGDRRMMKPLATALAEYGYHSFAIEYRLSGEAQYPAGIDDVISAIHYVKAHAEEFNIDSAKIVVLGTSSGGQMASLIGTKYPDKVAAVINIDGILAFHHPDSEEGAAAAAWLGGTFDEKPEIWKDASPLTHVSSKSAPVLFIGSQYTRFQAGREDMIKLLNNHSVYSHTQLIENSPHTFWMFEQWFDPVLGYITGFLNKQFSPQQIIHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P5</accession>
    <name>C6X1P5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01916"/>
    <dbReference type="EnsemblBacteria" id="ACU08358">
        <property type="protein sequence ID" value="ACU08358"/>
        <property type="gene ID" value="FIC_01916"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01916"/>
    <dbReference type="HOGENOM" id="CLU_3389559_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="32" mass="3672" checksum="53698BE601E514E0" modified="2009-09-22" version="1">MLKSCCDRAKIFVGKSLNLGNIYLKALWKNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R4</accession>
    <name>C6X1R4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar epimerase BlmG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806662.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01935"/>
    <dbReference type="EnsemblBacteria" id="ACU08377">
        <property type="protein sequence ID" value="ACU08377"/>
        <property type="gene ID" value="FIC_01935"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01935"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_10"/>
    <dbReference type="OMA" id="RSFMYID"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="335" mass="37733" checksum="143E6C9D28B99EB4" modified="2009-09-22" version="1">MKNVIVLGGGGFIGGHLAKRLKNEGNHVRICDIKKHEYFDHSDICHEFILGDLTDPKVVELVIEENVDEVYQLAADMGGALYIFTGENDANVMHNSAMINLNVAKECVTKKVKKVFYSSSACMYPEHNQLDPDNPNCEESSAYPANPDSEYGWEKLFSERVFLAFNRNYKLDVRIARFHNIFGPQGTWKGGKEKSPAAMCRKACETENGSKIEVWGNGLQTRSFLYVDECVEAVIRLMNSDFTGPVNIGSEEMVTINQLAQMAIEISGKDLTISNIEGQEFIDKYGFKCPLGVKGRNSDNQLYREKIGWEVSQPLRVGMETTYSWINEQSKLQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R5</accession>
    <name>C6X1R5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01936"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08378">
        <property type="protein sequence ID" value="ACU08378"/>
        <property type="gene ID" value="FIC_01936"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01936"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_2_2_10"/>
    <dbReference type="OMA" id="LVNFRRH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="45"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="285" mass="32877" checksum="B4D41BAC271D66B2" modified="2009-09-22" version="1">MRALGNKLTRSRVIKNIFCMSIELNYYIYALQNTILIGLGRMTKSICMASYNGSPFIAKQIASILPQLHDGDELIVVDDCSKDDTLQIVRSFDDPRIKLHSNSANQRHVKTFSKAMSLAANELIFLCDQDDIWEMDRLDIFEEKFLEFPEVQLITSNFYCIDDNDQPVEHKLNKVSASTSFNYKSNIIRILKGDIGYYGCAMAFRKDLLPVILPVPDYVEAHDLWIAMAANLLRSNLHIEEKTLAHRIHHSNTSNLNRSLIKKIDARIGFIKQYRDLSKRQKFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R6</accession>
    <name>C6X1R6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pectate_lyase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806664.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01937"/>
    <dbReference type="EnsemblBacteria" id="ACU08379">
        <property type="protein sequence ID" value="ACU08379"/>
        <property type="gene ID" value="FIC_01937"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01937"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574594_0_0_10"/>
    <dbReference type="OrthoDB" id="1274675at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970547" description="Pectate_lyase_3 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate_lyase_3" evidence="2">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="475" mass="52694" checksum="F31571BBD58B2ACC" modified="2009-09-22" version="1">MQKIFLITLLLVSLLPSARTLNVVNFGANGKDKIDDTSAFQKCVDQLASEGGGTMEIPNGIYYISHLKFFGKKYSNITIRGFSSTIRQILPAKRISAHNGLYQTFAERLSADGCFVFDAMVSHQQDDSESIKNIKISGVKFETDVQKVGFDELMHQISAHGVSNFSVDNCSFTGFLGDGVAINAGTDYRFNRNAYNKNITIYNCKFDGVNKDNRQGISIYYSDGFLIENCSFKNITRGDMPGAIDIEPNSETQVSRNGIIRNCSFENIGGLGAVTIHTGKSSSLNKYSNKNFIVENCNFQNVRAAFCIVGHEKFMEYKTSENVIRILNSKVRNAEAIADIRSGFGILFSNVQFYDIHNAGLNTVTDGGANGITFDQCLFDNVSNIYGVVFYGKTTNINFKNSTFKNFAAHAITINDPLGIGTITDNVFYSSKYGRALPLVTSTISRSEILSKLNIKNNQYFGTFKHIDLQEFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S1</accession>
    <name>C6X1S1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-keto.6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806669.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01942"/>
    <dbReference type="EnsemblBacteria" id="ACU08384">
        <property type="protein sequence ID" value="ACU08384"/>
        <property type="gene ID" value="FIC_01942"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01942"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_6_0_10"/>
    <dbReference type="OMA" id="IHTQIHY"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="366" mass="40912" checksum="570D25CC947C853C" modified="2009-09-22" version="1">MIKFLDLQKINLAHQAEIEEKLLQTFRSGWYLLGNEVKAFEGHLAAYIGAEHAIGVANGLDALRLILRAYIEMGVMQKGDEIIVPANTYIASVLAISDNGLVPVLVEPDIDTYNIDISKIEEKITSRTRGVMIVHLYGRVVFSEELKRLAQKHRLKIIEDNAQAIGAEWVGVKTGNLGDAAGFSFYPGKNLGALGDAGGITTNDEELAKTIRALANYGSKQKYINIYQGLNSRLDEMQAAVLDVKLKYIEEENQVRKGIAARYISGIENAKIILPGNPSDAAEHVWHLFVIRTSEREKLQAYLTENGVQTLIHYPIPPHQQEAYREWNNLSFPVTEKVHSEVLSLPISPVLSEEEVERIVRIINQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S2</accession>
    <name>C6X1S2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FdtA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806670.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01943"/>
    <dbReference type="EnsemblBacteria" id="ACU08385">
        <property type="protein sequence ID" value="ACU08385"/>
        <property type="gene ID" value="FIC_01943"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01943"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127501_0_0_10"/>
    <dbReference type="OMA" id="AHAHKEC"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd20292">
        <property type="entry name" value="cupin_QdtA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008894">
        <property type="entry name" value="QdtA_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05523">
        <property type="entry name" value="FdtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FdtA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="138" mass="15516" checksum="1438037726AEF260" modified="2009-09-22" version="1">MSSKTVFDCSVIDLGKIDFAEGNLTVVENNSFFPFDVKRVFYLYDIAGGESRGAHAHKECHQFLIAASGSFEVELDDGIYKRQVFLNRPNIGLHIPPGVWASEVNFSSGAICLVLASHSYNEHDYIRDYETFLNFRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T5</accession>
    <name>C6X1T5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806683.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01956"/>
    <dbReference type="EnsemblBacteria" id="ACU08398">
        <property type="protein sequence ID" value="ACU08398"/>
        <property type="gene ID" value="FIC_01956"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01956"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_0_2_10"/>
    <dbReference type="OMA" id="RTCPEDD"/>
    <dbReference type="OrthoDB" id="871298at2"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="327" mass="36936" checksum="213EABB4E1EE886C" modified="2009-09-22" version="1">MLIIDSPSNNAYFNIAAEEYLLNRFPKEDLFLLYVNAPSIIVGKFQNTLAEINLDYVKEKNIKVVRRMSGGGTVYHDLGNLNFSFHTLLGKHDFMDFSIFTKPVITLLNNLGVPAELKGRNDLLVDGKKFSGNAKLARQGKMIQHGTILLDSEMEVLSQALTVNPLKFVDKATKSTRSRVTNLIDYLPETISTDELKNLLTAEIIKNNPEATRYQLTNEDLKGIEKFMTEKYETWDWNFGFSPNYNFKKGIKVPAGFIEVHLDVEKGSIQQAKIFGDFFAAEPIEEFEAKLIGIKHEPSQLLALLSSVNITQYFGNVEPAELIEAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V7</accession>
    <name>C6X1V7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806705.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01978"/>
    <dbReference type="CAZy" id="GT19">
        <property type="family name" value="Glycosyltransferase Family 19"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08420">
        <property type="protein sequence ID" value="ACU08420"/>
        <property type="gene ID" value="FIC_01978"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01978"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036577_0_0_10"/>
    <dbReference type="OMA" id="PTVWAWR"/>
    <dbReference type="OrthoDB" id="1258510at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="368" mass="41809" checksum="ACA569EAFF673D32" modified="2009-09-22" version="1">MKYYIIAGEASGDLHASNLMKSLKNKDPDAAFRFWGGDLMTEVAGSYPVKHYRDLAFMGFLEVAKNLRTIFRNIKLCKADIRNYSPDVLILVDYPGFNLRIAEFAKNLGIKVIYYISPQLWAWKEGRVKKIQKFVDEMLVILPFEKDFYKKHAVDAHFIGHPLLDAISFLKPVDASGFRLENGLNSKEIIALLPGSREQEVTKMLEIMLSVRPFFQEYQFVIAGAPSLPATFYQKYVDENVHFVSNKTYDLLRCSKAALVTSGTATLETALLDIPEVVCYRSSRISYEIGKRVVKDLKFISLVNLIMDRKIVTELIQDELTTQNLTRELTHILEGKDREKMLREFAMLREKLGGSGASDVAADIIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W5</accession>
    <name>C6X1W5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase paralog</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806713.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01986"/>
    <dbReference type="EnsemblBacteria" id="ACU08428">
        <property type="protein sequence ID" value="ACU08428"/>
        <property type="gene ID" value="FIC_01986"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01986"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_10"/>
    <dbReference type="OMA" id="INAVGNP"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="242" mass="26988" checksum="C32E12E610EA04E9" modified="2009-09-22" version="1">MSQVNKMVLILGANSDVAKQCILQYAQKGFAVTAASRDLNSLTSFVDAHQLDDFVEVIYFDAVDFSSHQKFNNELKTKPNIVIYAAGFLRQNDEVCRNFSDAFEMMKVNYAGAVSVLNIIAEDKSNTNLERIIGLSSLSGVRGRKSNYIYGSTKAAFTTYLAGLRQDLSSRNITVNVLVSGYIRTKINEGLQLNESLIMEPDYVAKHIVNAGNSFAIVPNWKWKIIYWILKLSPESLVAKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y6</accession>
    <name>C6X1Y6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ordered locus">FIC_02007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806733.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02007"/>
    <dbReference type="EnsemblBacteria" id="ACU08449">
        <property type="protein sequence ID" value="ACU08449"/>
        <property type="gene ID" value="FIC_02007"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02007"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_10"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="132" mass="14708" checksum="EE5DFDD9388A6D4A" modified="2009-09-22" version="1">MVTDPISDFLTRVRNAQSAGHKVVDIPASKIKKEITKILFDQGYILNYKFEDHAVQGNIKIALKYDKTTNKPAIKSIQRASRPGLRQYKGSQDLPRVLNGLGVAIVSTSRGVMTDKKARQEKVGGEVICYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X214</accession>
    <name>C6X214_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02035"/>
    <dbReference type="EnsemblBacteria" id="ACU08477">
        <property type="protein sequence ID" value="ACU08477"/>
        <property type="gene ID" value="FIC_02035"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02035"/>
    <dbReference type="eggNOG" id="ENOG502Z9YG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080120_0_0_10"/>
    <dbReference type="OMA" id="ACWRPLF"/>
    <dbReference type="OrthoDB" id="1695614at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="268" mass="30067" checksum="108583EC3063B31D" modified="2009-09-22" version="1">MCPKKRNFTFTKHEQMKTITTIEEVLLRLDDIIEWSQINKSPTGYFACTYKSMTLAVANGIKKRKFEDGKRMVALDVAFANRYLDAFENYRNKKKCSNAWFTAFEAAKNKDLLIMQHILLGINAHINLDLGVSAASIVPYRKIAPLKNDFNRINDVIAAINQKVQDSLNKICYPVGLIDELSNGQDNVMLDFAISKARQTSWASAFILSNSLVILRPSLINMIDNAATLVGRNIILSNKTPKSILKKFKSCESSDVAKNIEILAATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X284</accession>
    <name>C6X284_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrous oxide reductase maturation protein NosD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806831.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02110"/>
    <dbReference type="EnsemblBacteria" id="ACU08547">
        <property type="protein sequence ID" value="ACU08547"/>
        <property type="gene ID" value="FIC_02110"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02110"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041882_1_1_10"/>
    <dbReference type="OMA" id="RYGLHFM"/>
    <dbReference type="OrthoDB" id="1177619at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026464">
        <property type="entry name" value="NosD_copper_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04247">
        <property type="entry name" value="NosD_copper_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NosD" evidence="1">
        <location>
            <begin position="152"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="408" mass="46688" checksum="80CB0A55FB76C4D6" modified="2009-09-22" version="1">MFRILFLFFPVLIFSNVLRVGKNEQFKTIQQAVAASKSGDSILVESGVYREGNINITKPLTLIGIGRPVLDGEMKHEILSFRGHHIVLKGFKIINSGQDEIKNIGAIRLYDSHFSVIANNIFENNYFGIYIQRGYRCLIENNRITSSRSKSQEGIGDGIHAWVSEEIWIKNNYIEGHKDGIYLEKVTDSYIYRNFSKKNLRYGLHFMSSNDCVYVNNTFDNNNAGVAVMYSNNVGMAGNSFINNWGDANYGLLLKDISFSKIKQNRFSNNTIAIFMDGATKVDFFRNNFEDNGWAMKINSNCMENKFINNNFINNTFDVGTSGTMAMNDFKRNFWDKYEGYDLNKDKIGDVPFHPLSLYAVLVENNPAIMLLFKTFFVDLLDKTEKIIPSLTPENFKDEEPLMKKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X293</accession>
    <name>C6X293_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, M23/M37 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08556">
        <property type="protein sequence ID" value="ACU08556"/>
        <property type="gene ID" value="FIC_02119"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02119"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587472_0_0_10"/>
    <dbReference type="OMA" id="INRIATH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="182"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="449"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="520" mass="58846" checksum="78931EC2E619760E" modified="2009-09-22" version="1">MQCSEKLRAHRYKHPIMRSPTNLWLNVTTPVSYFINFITLKTQIMKSKKLLLLMLLPASAFSQQQSETFEIANRVHSGTAPVESSFTAVKFEKTECLTDVQRFQLRYEIARNRKAILEQNPDAFKTLQKITPFQNPFRPKAGFTDYGYHTLQYQVDHNLTPNNNLLDYNCGTRTYDWTNGNHQGTDFILWPYPWKRMQENTMEIVAAAGGIIVDKRNTFNDLNCTNNGNPSWNGVVIEHADGSFAVYMHFKKNSATTKEIGDTVAAGEFLGLAGSSGSSTIPHLHFEIRDAASNVIDPYQGACNSMNSASWWQQQENYYVPRINRIATHSSTAQDNTCPVVENTYEKVNFNTGDLLVLKLYYRDIKPGDVTNIKITDPNGSVTSNFDWTQNWGVFYPTAHAYWTFNVTSAWMTGVYNVQSTFGGNTYTTVFGVRTNLGTEESPQENISVYPNPVGDVLFIKSNNGIESAEIIDLAGRIVMKAGDELKESRITVATLIKGMYLLKFTDRNQKVKTVKFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B6</accession>
    <name>C6X2B6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division transporter, ATP-binding protein ftsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02143"/>
    <dbReference type="EnsemblBacteria" id="ACU08579">
        <property type="protein sequence ID" value="ACU08579"/>
        <property type="gene ID" value="FIC_02143"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02143"/>
    <dbReference type="eggNOG" id="COG2884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OMA" id="EFIYIIG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="248" mass="27675" checksum="A9F3EF08EAC802EA" modified="2009-09-22" version="1">MFRDFYSKNKTIMPHSSHEGHDVIQLNNAKIAQKNFTVLNGVNLNIKKGRFCYLIGKTGSGKSSLLKTLYGHIPLSGGQGSVAGFNLEGLRTSDVPNLRRKLGIVFQDFQLLTDRTVEKNLRFVLEATGWNDKTKIDDRINEVLASVGMKSKKHKMPHELSGGEQQRIAIARALLNHPELILADEPTGNLDPETSNEIMTLLKQVAFENNSAVVMATHDYHMIQNFPGEAIRCEDGKVTVLNTTELFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C0</accession>
    <name>C6X2C0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02147"/>
    <dbReference type="EnsemblBacteria" id="ACU08583">
        <property type="protein sequence ID" value="ACU08583"/>
        <property type="gene ID" value="FIC_02147"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02147"/>
    <dbReference type="eggNOG" id="ENOG5032RNF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905722_0_0_10"/>
    <dbReference type="OrthoDB" id="1789709at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045499">
        <property type="entry name" value="DUF6492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20102">
        <property type="entry name" value="DUF6492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="275" mass="33140" checksum="FCBFF182536D3781" modified="2009-09-22" version="1">MNSLIIFIKTYKPDFPRLNSLLQSIEKYNRESIPVVISVNDADFDYLDPAYQQKYKIYRDSEIMTTAIKDGWRYQQIIKSNVYRLNICRNYVCIDSDSVFIRDFYYSDFMYDTDTPYTVMHESKDLMEIAERIGLDSQDLFFKKSLRDTRPFFNNFGKDYDYGPSPYIWSCKVWEHFNAHFLKNLELSFDEFFTQIDRKGLSPSECTIYGEYLLQTRLIGIHPISALFKVYHYKKQFKIEKRLTEKQLSKIYLGVIYQSNWAARSKFWRFFKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C2</accession>
    <name>C6X2C2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806869.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02149"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08585">
        <property type="protein sequence ID" value="ACU08585"/>
        <property type="gene ID" value="FIC_02149"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02149"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_1_10"/>
    <dbReference type="OMA" id="VDCRCIN"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="179"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="359" mass="41660" checksum="53C07509376AEC97" modified="2009-09-22" version="1">MKNKVLIDLERLRYPRSGIATIFSHLAQGLESLPQSNIQLNLFAPSEPSNSGFPVLRWKKWSKLNPFLGQKFDLVHVSHQLSSYFHNKPKHQKKIVTLHDLNFLHENFSESKLKRNISRVNKNLQNADVVVCISEFVKQDYLKNQHLFKIQANQEVEVIYNGLKFPDTSKLFDLGEFEFLNNKKYFLNIGVLFPKKNQLSILKTMHLLDEDLVLVVSGSKKEYEAEVLKYIKDNHLENRVHILRDISDDQKHALIQHCEAMIHPSLAEGFGIPPIEAMHFGKPVFLSRLTSLPEIGGEQAFYFDDFEPLAMSQTIKNGMDTYRFDLKLAANLKSWAQQFDYRKMAQDYYSLYKKVLAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F9</accession>
    <name>C6X2F9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="3 13">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lpxK</name>
        <name evidence="14" type="ordered locus">FIC_02186</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the LpxK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="3 13"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02186"/>
    <dbReference type="EnsemblBacteria" id="ACU08622">
        <property type="protein sequence ID" value="ACU08622"/>
        <property type="gene ID" value="FIC_02186"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02186"/>
    <dbReference type="eggNOG" id="COG1663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038816_6_0_10"/>
    <dbReference type="OMA" id="MDDGFQN"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU08622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="344" mass="40225" checksum="C751822C762EA405" modified="2009-09-22" version="1">MPTMKRWYLYPFSVGYHFVTAIRNVMYDWGIFKSKSFKTPIINVGNLSVGGSGKSPMVMYLAEYLSKQYRTGVLSRGYGRITKGYGITNYDSNYKTVGDEAMQLFERFKNRFVIGVSEERVPGAQKMIDDMDLNVLVLDDAYQHRKIKPGFNILMTDYNDPYFKDFLLPAGDLRESRSGAARAQIIMVSKCPADLTDEKKQYYISRIKPQHDQKVFFSSIGYDENVYSADKFLPDNNLSYYDILLITGIANPKPLINHLANFSHRVKHLKFKDHHNFSDQDIKNILAEYKKLGEYKIILTTEKDYVRLKTFDYLRDLMYYWPINVIIDRKDDFNQIIQNYVSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G5</accession>
    <name>C6X2G5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanophycinase</fullName>
            <ecNumber evidence="4">3.4.15.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate</text>
            <dbReference type="Rhea" id="RHEA:12845"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13734"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137991"/>
            <dbReference type="EC" id="3.4.15.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.15.6" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02193"/>
    <dbReference type="EnsemblBacteria" id="ACU08628">
        <property type="protein sequence ID" value="ACU08628"/>
        <property type="gene ID" value="FIC_02193"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02193"/>
    <dbReference type="eggNOG" id="COG4242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053928_0_0_10"/>
    <dbReference type="OMA" id="AFAPEWI"/>
    <dbReference type="OrthoDB" id="1485646at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011811">
        <property type="entry name" value="Peptidase_S51_cyanophycinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032067">
        <property type="entry name" value="Cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02069">
        <property type="entry name" value="cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR032067-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="303" mass="33079" checksum="73849B53293C3552" modified="2009-09-22" version="1">MNLSKTTPLKRQAYFKKLNSRSMVNIKGKVLVIGGAEDKNGNSDRFSNTTILERFIDETRQKKRSRIEIITSASSIPEEVGKDYLKIFKKLGAENCGALIMRTRQEADDPANIERLKKADAVYATGGSQLALTSTLGGTEFYKLLTEKLQEPDFVYAGTSAGAAAASESMIIQGGSTEAAYKGEVTTATGLGLVKDIVFDTHFIERGRIARLFEVVVSNPAVLGVGLEENTALLIHRNKMEAVGTGMGILLDGRRITNSNLLEVVEGAPLSIENMTLHLMSEHDIFDLKDMKLKILNPPEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H9</accession>
    <name>C6X2H9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ordered locus">FIC_02207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806926.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02207"/>
    <dbReference type="EnsemblBacteria" id="ACU08642">
        <property type="protein sequence ID" value="ACU08642"/>
        <property type="gene ID" value="FIC_02207"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02207"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_3_1_10"/>
    <dbReference type="OMA" id="QMDIEQK"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="198" mass="22546" checksum="AA45F8B7AF76E161" modified="2009-09-22" version="1">MNKIIGLTGGIGSGKTTVAKFIEDLDFPVYYSDDRAKEIVNDDEDLKRRILALLGDKSYDGNGLYDRKYVSGIVFQNSELLLKLNALIHPAVKIDFESWTAKQNTAFIFKETALLFELDLHKTCYKSVLVTAEDNIRIKRVMERDGKTYREVEAVIQKQMPEKDKVKLADFVIYNNTDLAGLKEETDRMLMKLAGLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U9</accession>
    <name>C6X2U9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807046.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02329"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08762">
        <property type="protein sequence ID" value="ACU08762"/>
        <property type="gene ID" value="FIC_02329"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02329"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_4_4_10"/>
    <dbReference type="OMA" id="IMVSICC"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="295" mass="34154" checksum="9EE4C9787EB6D3CF" modified="2009-09-22" version="1">MTRISIVILTYNHEKFIGQNLAGIFSQAVDAAVEVIICDDHSQDQTDSEITKSLENISDGFNVKYIRHSKNMGATPNFYFALEQVTGDFVAFCEGDDYWTDPHKLQHQLDFLKNNPDYSMCFHAAQNIADDPAVNGTLFSDIETRDYSQLEIYRHWIVHTATVMMRSEVLRSAAKKATMKDQSLQYFDTVLFLAARSVGKVHGFEKVMSAYRRHDAGLSAGKVNYKRDLKHNKLDAVIGKYYKGDISKFSDWQIFTRSYRNFKSLLSESKWKTALQYLPWLLRNRTIVYYFLKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y8</accession>
    <name>C6X2Y8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807085.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02368"/>
    <dbReference type="EnsemblBacteria" id="ACU08801">
        <property type="protein sequence ID" value="ACU08801"/>
        <property type="gene ID" value="FIC_02368"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02368"/>
    <dbReference type="eggNOG" id="ENOG5032QUM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147286_0_0_10"/>
    <dbReference type="OMA" id="IPAFYYQ"/>
    <dbReference type="OrthoDB" id="2016697at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026414">
        <property type="entry name" value="ExosoTase_F-assoc_pro"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04127">
        <property type="entry name" value="flavo_near_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="143" mass="16982" checksum="C67D6923FD1F5561" modified="2009-09-22" version="1">MKLLNWLAVFAGILGLIGVRMAEDAIFYDPFLKFFRAADDRAVFPDFEWANLVISYIFRFSLNLLFSLIVVHFIFKNKRWTIQAAVLILMVFAITLPVYLYCVYTRFEIGYLFSFYMRRFVIQPLILLLIIPLFYYRKKMTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X318</accession>
    <name>C6X318_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase</fullName>
            <ecNumber evidence="1">3.2.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.20" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807115.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02398"/>
    <dbReference type="EnsemblBacteria" id="ACU08831">
        <property type="protein sequence ID" value="ACU08831"/>
        <property type="gene ID" value="FIC_02398"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02398"/>
    <dbReference type="eggNOG" id="COG2818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083758_1_0_10"/>
    <dbReference type="OMA" id="YVAYHDT"/>
    <dbReference type="OrthoDB" id="1835478at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="21601" checksum="C7CA2EFED4A236B8" modified="2009-09-22" version="1">MNKKRCSWCEKDDLYRKYHDEEWGKPVYGDAAIFEFLVLESFQAGLSWYTILKKRENFRTAFDDFNYHKIAEYKDEKVELLMQDAGIVRNRLKVLATVSNAQRFLEVQAEFGTFSKYIWTFVDGKPIVNNPQTLKDVPATSEISDQLAKDLKKRGFKFLGSTVMYAHMQATGMVDDHVEDCHCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X329</accession>
    <name>C6X329_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ordered locus">FIC_02409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807126.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02409"/>
    <dbReference type="EnsemblBacteria" id="ACU08842">
        <property type="protein sequence ID" value="ACU08842"/>
        <property type="gene ID" value="FIC_02409"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02409"/>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_1_2_10"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="OrthoDB" id="1680292at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="171" mass="18297" checksum="BAB85A7DB75C4A5A" modified="2009-09-22" version="1">MATVNLSDYKPLQINDAGSFRIGIVVSEWNDFVTHNLRDAALQVLQTEGVSAENISVYTVPGAFELNYAAMQLCKEGVFDAVIAIGCVIRGETPHFDYVCSAVAQGIKDCNILTDVPTIFCLLTDDTKEQSLARSGGTLGNKGVEAAVTALQMIAFKQNLSAKKSNIGFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X331</accession>
    <name>C6X331_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ordered locus">FIC_02411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
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        <property type="reaction ID" value="UER00646"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:purine ribonucleoside salvage"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="49"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="178" mass="19873" checksum="E451985D1E0F4681" modified="2009-09-22" version="1">MTNQKLIRELENTIENIPDFPKPGIQFKDITPIFLKPDLYEDIIEDLANFSRGKIDAVCGIESRGYLFGIAIAVALKVPFILIRKAGKLPPPFVGEKYDLEYGSAEIEMRTGQIKPGQRILIHDDLLATGGTTEAAAKLVNKQGAVVSQFSFLIGLKALEGEERLRQFDAEIYKTLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X338</accession>
    <name>C6X338_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Molybdopterin oxidoreductase subunit, predicted chaperone protein HtpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_02418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_013062.1"/>
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    <dbReference type="EnsemblBacteria" id="ACU08851">
        <property type="protein sequence ID" value="ACU08851"/>
        <property type="gene ID" value="FIC_02418"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
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        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973650" evidence="8">
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            <end position="455"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="238"/>
        </location>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="455" mass="50955" checksum="BBFF6F9BE8600237" modified="2009-09-22" version="1">MISWRKHYKRGLIAIGLLLSASASIYAQGDAKNGEKLFKANCTACHALDKQLIGPALGGVVERLKTEQSLDNEWLHKWIKDNKALRESGDKYAIEVYEKFNKVEMTPFPNLSDKDIDDILEYTTNPPAPEPAADAATAGADAGNSAASMQASQAESQNSKIILISMVAIAGLLIWLLLKLNQLVKLQQSEELRGAQSSQAVSWGELYRKYHYVGKGLLALLGIFAAYGIWNSLMWIGVYKGYKPEQPIYFSHKIHAGENKIDCQLCHSSAKYGKVSEIPSMNVCMNCHRTISEYNGKYMEPGKDKAFYDGEIQKIYAATGWDPEKQQYTGKTQPVEWVRIHNMPDFVYFDHSQHVVAGEQAIISSHNKKNPEAKIDVVCKACHGQVDTMNVVQMANDFTMGWCVECHRTTEVDMTNGYNKEYFKNLHDKLKKQYGSETKITVDAIGGLECGKCHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X341</accession>
    <name>C6X341_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component regulatory system, sensor kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807138.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02421"/>
    <dbReference type="EnsemblBacteria" id="ACU08854">
        <property type="protein sequence ID" value="ACU08854"/>
        <property type="gene ID" value="FIC_02421"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02421"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026375_1_0_10"/>
    <dbReference type="OMA" id="KFYREHT"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="297"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="519" mass="59330" checksum="9812E0B9D7290F88" modified="2009-09-22" version="1">MNNRFIPFISILMTISMIVFVTLQLYWIKELYSALNQDFSNKVYAALESSAAKAQQMEVEKYLNQDYRNFAKNVIDSSNQPTQTYIQQNSDSANRSTITFQKSIVENQNFPISPRGDSLQLTKLYTDEGILKIKRPENTSEPLTAQLSKDINNNTYALREFAKLSASNLPVEKRVDLKTLDSVLARELKMNGLSSKFGFAVMDKQNKPTGIVNDIYLEQKDKNNYTYPLFTDSKERTLYTLALVFPRKDYSLAKNNLPMLLGTFMSLLTILGIYVISINYMMRQKKIAEVKTDFINNMSHEFKTPLATISVATDSLANDKIATNPEKVKYYSGLIKQENLRMKKQVENVLNMSKLERNEVKLFLKETDVRELIKRISESFGLIVAQRNGTFTQEFTTKQYHLKVDEFHLSNALVNLLDNANKYSPEAPEIKVKTSNEGNWYVVEISDKGIGMDVDNKTRIFEKFFREETGNIHNVKGQGLGLSYVKKIIELHKGQILVDSKKGVGSTFTIKLPMSPQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X347</accession>
    <name>C6X347_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02427"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08860">
        <property type="protein sequence ID" value="ACU08860"/>
        <property type="gene ID" value="FIC_02427"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02427"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_0_10"/>
    <dbReference type="OMA" id="TAYIHGF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="252" mass="28939" checksum="28B207C85C508118" modified="2009-09-22" version="1">MKAGKVYLCQLIAWMKKLVIIPTYNEKENIEQIISAVFALEEDFHILIVDDSSPDGTAEIVKNMRQTYPLHLHLNIRKVKDGLGQAYLHGFRWALQNQYDYIFEMDADFSHNPKDLNRLYEACQQADMSIGSRYSKGVNVVNWPMGRVLLSYFASKYVRFILGIPIHDTTAGFVCFSRKVLENIGLEDIKLKGYGFQIEMKYRAIKKGFKVVEVPIIFTNRELGQSKMHGGIIHEAVFGVLDLKIKSWLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X369</accession>
    <name>C6X369_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807166.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02449"/>
    <dbReference type="EnsemblBacteria" id="ACU08882">
        <property type="protein sequence ID" value="ACU08882"/>
        <property type="gene ID" value="FIC_02449"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02449"/>
    <dbReference type="eggNOG" id="COG2928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068050_4_1_10"/>
    <dbReference type="OMA" id="QNDRIPL"/>
    <dbReference type="OrthoDB" id="1305123at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="206" mass="22852" checksum="212649754E49290A" modified="2009-09-22" version="1">MNRERAEQLLNTLAKSFFQGLLIVGPFAVTIWIIWYIVSSIDNIIPAVSERLYPGITFMIVILGTALIGYLGNKFIIGRVVVDSFDYLLEHTPGIKFIYTSLKDVMTSFVGDKKKFNQPVLIKTTDEPEVWRIGFLTQSDLSSVGFPDYVSVYLPHSYAVSGWVVFVLAENIVVLENVTAAQAMKFAVSGGVAGFHSDDSVFKAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X384</accession>
    <name>C6X384_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08897">
        <property type="protein sequence ID" value="ACU08897"/>
        <property type="gene ID" value="FIC_02464"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02464"/>
    <dbReference type="HOGENOM" id="CLU_3389561_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="32" mass="3945" checksum="2FE7A1AE5F39289E" modified="2009-09-22" version="1">MNLFNEKLSRNPKMATVIKIFNNLNFFFIYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G0</accession>
    <name>C6X3G0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP oxidoreductase coenzyme f420-dependent superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807257.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02543"/>
    <dbReference type="EnsemblBacteria" id="ACU08973">
        <property type="protein sequence ID" value="ACU08973"/>
        <property type="gene ID" value="FIC_02543"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02543"/>
    <dbReference type="eggNOG" id="COG5495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055635_1_1_10"/>
    <dbReference type="OMA" id="FACNFTN"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="120"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="28497" checksum="4B3F58BA72ABB204" modified="2009-09-22" version="1">MKIVIVGSGNVAYHLVKSFHEKNIGISQIFGRNEHEVNEISRDFNIPFSTSAIADADFYLIAVKDDAVAEVSKIITAENCVVAHTSGSLPKEILAGNYRKASFYPLQTFSKYKSLDYSEIPFFIESDHAADLEMMTNLASRISKNVMKSTYEKRKYLHLTAVFACNFVNHLYARAKEISDSQDIPFNHFLPLISETTTKIYSIEPKLAQTGPAVRDDLRVLEMHENLITDEDHLKIYRTMNESIRKMYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H4</accession>
    <name>C6X3H4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable outer membrane receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807271.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02557"/>
    <dbReference type="EnsemblBacteria" id="ACU08987">
        <property type="protein sequence ID" value="ACU08987"/>
        <property type="gene ID" value="FIC_02557"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02557"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020298_0_0_10"/>
    <dbReference type="OMA" id="FRAEAYY"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972271" evidence="1">
        <location>
            <begin position="24"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="739" mass="82436" checksum="3E6A338EE0781FEA" modified="2009-09-22" version="1">MQTFIISKLLALFGIILSCSLTAQITVAGKVNFKNKGVKDISVTLKDTYDGATTDESGAFTFETSEKGNLILVFSNPKFVEIEKAVTIDNQPVTVNVDLKEQISEIDAVVISAGSIEASDRKRATVLLTPIDIYTTAGANGQVTSALETLPGVQKVGETEGLFVRGGTGSETKFFMDGNLVNNFFGNSVPGLKAMDRLNTSLFKGNVFSSGGYSALYGQALSSVLVLESIDFPEMNSVDIGISPIFLSAGFQNVDDAKTKSFGISAAYSNLGLVTEILKFNTDFIKAPRSIGTNFNFRIKNKMGGILKYYGSFDENTLGIQEESLEPETDYSQTSLKGTNTFHNLSFKQKFGNYLLNIGSSYSYNRNLIGLNDIFENAEFNANSIDSKGNYFNSKATVERKINRISAVRGGIEFNKTREETVVALSPLNYRFDEQITSLFAETDLGFSNDFSAKVGLRTEHSAALDRWNLAPRAALAYRISKKWTSSLAYGIFYQNPENQFIGKYPLNFQRAEHYILQVQKSEEGRSLRLEAFYKNYRDLIKTRLEDYRPVAISNNGDGFAQGIEFFWRDKKSLKNIDYWVSYSFLDSKRNFQNYDRSLFPNFAAKHTLSVVAKKFVVDWKTGFNISYSYASGRPYYNFMTDTNGDYYLNNQGKAKDFSALNFSMNYLPFLGRKDAKSFTVLVLSVNNILAQKNNYGYNFSNDGLRSRPILPSADTFVFIGAFISFGIDRTQDAIDGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I2</accession>
    <name>C6X3I2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component system sensor protein histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02565"/>
    <dbReference type="EnsemblBacteria" id="ACU08995">
        <property type="protein sequence ID" value="ACU08995"/>
        <property type="gene ID" value="FIC_02565"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02565"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_0_1_10"/>
    <dbReference type="OMA" id="KMRFEDS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025698">
        <property type="entry name" value="2TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13239">
        <property type="entry name" value="2TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="199"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="2TM" evidence="3">
        <location>
            <begin position="398"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="479" mass="55704" checksum="F6511F3F5C76060C" modified="2009-09-22" version="1">MTDDRIQCLDFTVEYAKSATEQETVLFICKLRYICITIFKRMSRKSFVNIFWISLASGLFFFTFFSPDKTFENFLFYVLTSVFYTFVLAVGNGVVNDFLNKRYSWVAQTRKRTIYGVIALLITNFTLAYFCNYTVFVVVKGMSIEQFFSAEMNFNNWFIVNVALLISAVLHARAFMEEWKKSTRKEVVEQKLIAKSANAQFESLKNQLDPHFLFNSLNVLSALIDENPEQAQNFTAAMSKIYRYVLEQKDKELVTVEEELDFARTYCELLETRFEDSVSFGFDVNAEVLRSYVVPLSLQLLLENCIKHNFATTQKPLNVKIYSDGGFLLIENNMQTREQVKESAGIGLSNIVQRYALLTSQNVFIEKSADFFRVKIPILTKKITAMNTQTSDETVAYERASKRVKELKGFYGNLISYCLVIPFLIFVNLYTVPQYHWFWWPMLGWGIGLASHAFQVFGIGRNWEEKQIQKILEKEKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M6</accession>
    <name>C6X3M6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ordered locus">FIC_00556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782161.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00556"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="ACU07014">
        <property type="protein sequence ID" value="ACU07014"/>
        <property type="gene ID" value="FIC_00556"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00556"/>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_10"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="193"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="509" mass="56892" checksum="678B6E2507BF0A3D" modified="2009-09-22" version="1">MQHGIIILDFGSQYNQLIARRIRELGVYSEVLPFDTSLDEILSRKPSGIILSGGPSSVNIENARLVDRQLFENNIPVLGICYGMQLITHLLGGKVKKGDKGEYGKAKLEILKGNALLSGISRYSTVWMSHFDEVQELPAGFVTNAVSDVISAISNEAQKIYGVQFHPEVSHTEEGARMIENFVFGISNAPKNWKLTNYIDKTVAEIKEKVGQHKVILGLSGGVDSSVAAVLIHRAIGDQLQCIFVDTGLLRKEEAEKVMKNYGEHFKLKIKLIDAKDRFLSKLKGISDPEEKRKIIGNEFVVVFDEESHKIEGAKFLAQGTIYPDVIESQSVKGPSAVIKSHHNVGGLPAEMDFELLEPLRELFKDEVRKVGEELGIPHHLVHRHPFPGPGLGIRILGEVDNEKVQILQHADDIFIEELYKNKLYETVSQAFVVLLPVKSVGVMGDERTYEYTAVVRSANTTDFMTATFSRFPWEFLETVSNRIINEVRGINRVAYDISSKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S9</accession>
    <name>C6X3S9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component system sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782214.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07067">
        <property type="protein sequence ID" value="ACU07067"/>
        <property type="gene ID" value="FIC_00612"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00612"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559909_0_0_10"/>
    <dbReference type="OMA" id="WENYHNE"/>
    <dbReference type="OrthoDB" id="1753310at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973539" evidence="1">
        <location>
            <begin position="19"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="488" mass="55993" checksum="C09C2D81B1E8AD82" modified="2009-09-22" version="1">MRKTLFIFFAGLTLQANAQNIFPVKLENCKTEKFCLDCGDTKAGYDQNEFTKLQEKLNNELNLQGIKGAVKFQVLVDAKGRACVLSHTDKSNNPISLKIIEELNKFKKWIPAITSGKHEEKSSINLIFAISDNKISGQIERVDMNAFKKSFDKPNSPEIYNKTYEYKNENLKNYKITVWNSNNSNLPNNTNDNITIDKNGLVWLTVDEGLVTFDGKEFKNAEQNITDKGKFFSYYALATDNNNVKWVYGTKNIYSFDNAKWKKYDSTEIGIDGAYEIVNNERTGEVFFCSDEGVTIYKDGKWTNLNNSKFKDLPSNRVTFAKRDSKNRIWIGTFSGTAMIDENNQVTNFENTNTVLKGKCITSMDEDENGNLFFTLYEFDRKEKGKVNNNEGIAIRYTDGTFKQFTTENSGMPFNHTNCVLYDKSEKVLWISTDRAGLVRYDLKNGWENYHNENSDIPTSYISTMTFDDKGNLYLATRQGLVKIERKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V8</accession>
    <name>C6X3V8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00641"/>
    <dbReference type="EnsemblBacteria" id="ACU07096">
        <property type="protein sequence ID" value="ACU07096"/>
        <property type="gene ID" value="FIC_00641"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00641"/>
    <dbReference type="eggNOG" id="ENOG5033VET">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124453_0_0_10"/>
    <dbReference type="OMA" id="MNIEILT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="139" mass="16081" checksum="C5838A48CAA1C376" modified="2009-09-22" version="1">MNIEILTITPISGQFVEFHFGENFIESLWVDFNISEENHSIGCFSKDYENAINKVLYNEKDKTCCVVAGGKCYLLNFENKNLIFETDEYPIIQSLVQSSEYYFLGNYYSVYILNQNGLVKEIEPDIMVDGIYLEHKESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V9</accession>
    <name>C6X3V9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coproporphyrinogen-III oxidase</fullName>
            <ecNumber evidence="7">1.3.98.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00642</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX</text>
            <dbReference type="Rhea" id="RHEA:15425"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="1.3.98.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7 9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the anaerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.3" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782243.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00642"/>
    <dbReference type="EnsemblBacteria" id="ACU07097">
        <property type="protein sequence ID" value="ACU07097"/>
        <property type="gene ID" value="FIC_00642"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00642"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_3_0_10"/>
    <dbReference type="OMA" id="HILNLMC"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051989">
        <property type="term" value="F:coproporphyrinogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004558">
        <property type="entry name" value="Coprogen_oxidase_HemN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000167">
        <property type="entry name" value="HemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00538">
        <property type="entry name" value="hemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="46"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="459" mass="52589" checksum="E9C5075D19D25BD4" modified="2009-09-22" version="1">MNTSLIDKYNIPGPRYTSYPTVPFWDETSFTPELWQQSVIKSYNESNDAEGISIYIHLPFCEQLCTFCACHKRITKQHSVEIPYLESVLKEWDLYLDLLQGEGSIGGKPKIKELHLGGGTPTFFSPANLKTLLEGIFSKADIAENPEFSFEGHPNNTTREHLQTLYDLGFRRASFGVQDYDPQVQKAINRIQPFENVERVTNWAREIGYKGISHDLVFGLPFHTWEKMEFTIRKTLELKPDRLAFYSYAHVPWIKGVGQRGFDENDLPSGEEKRKLYENGKRLLEELGYIEIGMDHFALPHDDLYQSMVSGDIHRNFMGYSSGKTQLMIGLGMSAISDSWYAFGQNEKTVEGYQKMVEEGRIPVVKGHILNGEDLNIRQHILNLMCRLETSWDLGTSFPEIGDALEALKEMENDGLVTLTDNSITITDKGRAFTRNVAMTFDLRMMRNKPETRIFSMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X400</accession>
    <name>C6X400_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00683"/>
    <dbReference type="EnsemblBacteria" id="ACU07138">
        <property type="protein sequence ID" value="ACU07138"/>
        <property type="gene ID" value="FIC_00683"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00683"/>
    <dbReference type="eggNOG" id="ENOG5033WWM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2080588_0_0_10"/>
    <dbReference type="OMA" id="EHYTHEV"/>
    <dbReference type="OrthoDB" id="2027203at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="12913" checksum="9E6170FF46BD4A92" modified="2009-09-22" version="1">MLTGKTLRNYFSALILAVYLFAALFSQNFHHHQSTVYQTSDGISAGNDFSKSYSVADGAGCLWCHFLYTGNSCLPEEFSFNFESFTGFSAEIFSFDFDSVFLLSGAVFLRGPPLGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D9</accession>
    <name>C6X4D9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00824"/>
    <dbReference type="EnsemblBacteria" id="ACU07277">
        <property type="protein sequence ID" value="ACU07277"/>
        <property type="gene ID" value="FIC_00824"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00824"/>
    <dbReference type="eggNOG" id="ENOG5033WVA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1913947_0_0_10"/>
    <dbReference type="OMA" id="EVVFIRY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="132" mass="15527" checksum="8AF243DDC543CFC6" modified="2009-09-22" version="1">MKLSANNLYIVLYFVLFFVHFALWKYLNVGFEVVFIRYYIFLTLLFVLAITALTVIRKQVPQYIGFGFLGLVMVKMMALFIVMNQLELSTVPNYKLHFAIPYLVSLVLETLYAVKLIQIEEQTRVEKDEKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4G0</accession>
    <name>C6X4G0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="11" type="ordered locus">FIC_00845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782444.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00845"/>
    <dbReference type="MEROPS" id="C26.965"/>
    <dbReference type="EnsemblBacteria" id="ACU07298">
        <property type="protein sequence ID" value="ACU07298"/>
        <property type="gene ID" value="FIC_00845"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00845"/>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_0_0_10"/>
    <dbReference type="OMA" id="DKVPHMG"/>
    <dbReference type="OrthoDB" id="1726024at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="194" mass="21218" checksum="F19EAE0B4D57115F" modified="2009-09-22" version="1">MIAIIDYAAGNVRSVENAVQKLGFNTVLTDDAETIRKAEKVIFPGVGEASTAMENLKKKGLDVLIPTLVQPFLGICLGQQLLCAHSEEGNTAGLGIFDSYVKKFPSGYTVPHMGWNSLSKRQSQLFNGIGDDEDFYFVHSYYCTLGTDTSSVCDYIIPFSATLQKNNFFGTQFHPEKSGDVGSAVLNNFLNIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I5</accession>
    <name>C6X4I5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782469.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00870"/>
    <dbReference type="EnsemblBacteria" id="ACU07323">
        <property type="protein sequence ID" value="ACU07323"/>
        <property type="gene ID" value="FIC_00870"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00870"/>
    <dbReference type="eggNOG" id="ENOG50314C3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116689_0_0_10"/>
    <dbReference type="OMA" id="TCSSKHA"/>
    <dbReference type="OrthoDB" id="1580944at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="22173" checksum="3B1EEC20ACB01E91" modified="2009-09-22" version="1">MIFNFKITVDDEISKRFRALGVNDFLAASQFVRNLPYRRNSDKDDPYCVLRSGGGTCSTKHALLKRLAEENGIYDVRLMLGIFMMDRQNTPKITTVLNKYKLNGMPEAHNYLRWKDHVLDFTLKNSSADDFISHLENEIEMQPDQITDFKIKYHQNFLRQYLDKNPAVPYQLEEFWRIREECIAALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I8</accession>
    <name>C6X4I8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782472.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00873"/>
    <dbReference type="EnsemblBacteria" id="ACU07326">
        <property type="protein sequence ID" value="ACU07326"/>
        <property type="gene ID" value="FIC_00873"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00873"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_2_0_10"/>
    <dbReference type="OMA" id="FVKAWKG"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:3-oxoacid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="236" mass="25830" checksum="B752F3AFA30FF499" modified="2009-09-22" version="1">MIDKRVKNATEAIEGISDGMTLIIGGFGLCGIPENSISALVESNVKDLTCISNNAGVDDFGLGLLLQKKQVRKMISSYVGENAEFERQMLSGELEVELTPQGTLAEKCRAAQHGIPAFYTPAGYGTEVAEGKEIKDFDGKPHILEHAYKADFSIVKAWKGDHAGNLIFKGTARNFNAPMAGAGKITIAEVEELVEPGQLDPNEIHIPGIMVQRIFQGEKFEKRIEQRTVRKRDNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K4</accession>
    <name>C6X4K4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HSDR_N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782488.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00889"/>
    <dbReference type="EnsemblBacteria" id="ACU07342">
        <property type="protein sequence ID" value="ACU07342"/>
        <property type="gene ID" value="FIC_00889"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00889"/>
    <dbReference type="eggNOG" id="COG4096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115841_1_0_10"/>
    <dbReference type="OMA" id="EWVRQHV"/>
    <dbReference type="OrthoDB" id="1452055at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="144" mass="17230" checksum="3378D7E94494CA9A" modified="2009-09-22" version="1">MQLPKLNFEDTFDFKIRSDKDKIFIYDIVRRTWLQLTPEEWVRQHWVHYFHLKKGRNLSSLILEKKLVLNGTTKRIDLLITEKTIPKILVECKAPEIKLIQKTFEQTARYNSVIGAEEIILSNGNHHIYAKFTDNQYVFLPFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L0</accession>
    <name>C6X4L0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07348">
        <property type="protein sequence ID" value="ACU07348"/>
        <property type="gene ID" value="FIC_00896"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00896"/>
    <dbReference type="eggNOG" id="COG2323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089304_0_0_10"/>
    <dbReference type="OMA" id="EMRSSRY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="243" mass="26723" checksum="32BA179C740D8BAB" modified="2009-09-22" version="1">MAIGGETIAKMKTILAIDWSAIIYGAEDWSFLPEVAIRTVVMFLIIILGLRFLGKRGVKQLSVFELVVIIGLGSAAGDPMFYKEVGIIFSLLVFIIIVALYAGLTYFLGKSKKFEDLVEGKAACLIEEGVFVLDSFKKENLGSDEFFAELRLRGVSQLGQVETAIAETSGGLSVFFYSDENIKPGLSIMLGSLQNPVTKIDKSAYYSCIFCAYTEEKQPGPAGKCPKCTREEWVEASHKKRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N9</accession>
    <name>C6X4N9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00926"/>
    <dbReference type="EnsemblBacteria" id="ACU07377">
        <property type="protein sequence ID" value="ACU07377"/>
        <property type="gene ID" value="FIC_00926"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00926"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062205_1_1_10"/>
    <dbReference type="OMA" id="THQNENS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970668" description="Peptidase_M23 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="272" mass="30906" checksum="D26B4415C53EAA74" modified="2009-09-22" version="1">MMKFVFSFLFLALHVLVSAQQKWEIRFYTETVNREIFIYADNDEPMPMSAQYKFKLVNLDNTLRNGEIVVVPAKTKKFLIAKLSPIELKSGNQFSFTNSFNFGDARQQNYDVNYVYSLPFETGKTQLIYQGYNGKFSHSGEFSLDFNLQTGDAVMAARDGIVTEVTDHNTKSCPSISCANYNNRILIMHSDGTFADYAHLKYKGTTVKKGDRVEKGQLIGYSGNTGFSSGPHLHFAVFLNRIDGKRVFIRTKFQTSAGEQILQKGKSYTKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q0</accession>
    <name>C6X4Q0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ordered locus">FIC_00937</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell inner membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782534.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00937"/>
    <dbReference type="EnsemblBacteria" id="ACU07388">
        <property type="protein sequence ID" value="ACU07388"/>
        <property type="gene ID" value="FIC_00937"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00937"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_2_0_10"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="14" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU07388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="270" mass="30214" checksum="8D16FB11F6FCC059" modified="2009-09-22" version="1">MDLFKAILIAIIEGLTEFLPVSSTAHMIFTSSLFGIQEDEFVKMFQVSIQFGAILAVVFLYWKKFFDFKNLSFYLKLAVAVIPALVLGKLLDDKIEAVLGDPVPIAIVLILGGVVMLFIDKLFKTQVIDDEKDVSYKSAIIIGFWQCLAMMPGTSRSAASIIGGMQQKLTRKAAAEFSFFLAVPTMLAVTVYSIFVKDWNYKGIEQKGFEMLLQGDNLMLFLVGNIVAFVVAVLAIKFFIGVLTKYGFKPWGWYRIIVGIVLLIYFTQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q2</accession>
    <name>C6X4Q2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782536.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00939"/>
    <dbReference type="EnsemblBacteria" id="ACU07390">
        <property type="protein sequence ID" value="ACU07390"/>
        <property type="gene ID" value="FIC_00939"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00939"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_10"/>
    <dbReference type="OMA" id="SMEFAPF"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="27376" checksum="FAF4715F85B3E5E2" modified="2009-09-22" version="1">MQTRINKYLSEVGFCSRREADRMLEQGRITVNGNIPEMGTKVSGEDEILVDGVSIRKVEEEHVYIALNKPVGIVCTTDTKRERDNIVEFVNHPKRIFPIGRLDKPSEGLILLTSDGDIVNKILRARNNHEKEYIVRVDKPISPQFLHKMRNGVPILGIITNKCEVEQIDTLSFRIILTQGLNRQIRRMCEYLGYEVKKLKRIRIMNIKLDLPIGKWRDLSAQELAELNALLGDSEKTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q9</accession>
    <name>C6X4Q9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00946"/>
    <dbReference type="EnsemblBacteria" id="ACU07397">
        <property type="protein sequence ID" value="ACU07397"/>
        <property type="gene ID" value="FIC_00946"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00946"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010448_0_0_10"/>
    <dbReference type="OMA" id="GQGFYKK"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_N" evidence="10">
        <location>
            <begin position="23"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="9">
        <location>
            <begin position="224"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="813" mass="90278" checksum="8A55C39D4586EFFC" modified="2009-09-22" version="1">MGIIISIRHTKIKIKKMKRRIKHVTVLGSGIMGSGIAAHFANIGVEVLLLDIVPFELSEAEQKKGLTLEDKNVRNKIASENLAKLKKSSPALLYSPKFADRISVGNFDDDLKRIKNTDWIIEVVVERLDIKKSVYEKIEQFRTPGTLISSNTSGIPIHHLVEGRSEDFKKHFAGTHFFNPVRYLPLLEVIPTPETDPEIVQFYMDFGAKFLGKTTVLAKDTPAFIANRVGVFSMMNLLHEVKGLGLTVTDIDKLTGPVIGRPKSATFRTADVVGLDTLVMVANGVSASGTEASNSNDVFKLPEYIQTMVDNKWLGSKSQQGFYKKIKNAEGKSEIHGLNLETMEYELQEKTSFPTLELTKNIDKPIDRFKVLIEGKDKAGELYRKSLGALFGYVSHKVPEISDEVYKIDDAMRAGFGWENGPFEIWDAVGVQKGIELAAAAGYEVSDWVKNVDTFYKVNEEGQSTYFDKNSGNYLNTPGKESFIILDNIRKNKTLWSNSGSAIQDLGDGIINFEIRSKMNSLGGEVLDGLNRAIDLAEKEYDGLVIGNQGANFSVGANLAMILMMAIEQDWDDLNMAIAYFQKSMMRVRYSSIPVVVAPHGMTLGGGCEMTMHADRVVAAAETYIGLVETGVGVIPGGGGTKEFAIRTSREFQKDDVKNNRLRDMFMNIAMGKVATSAYEAYDMGILEEHKDIVVVDKNRQIKTAKMLALSLAEHGYTQPIEQKVQVLGKDALGMFLVGTDQMLTGKYISEHDKLIADKLANVLVGGNLSEPTVVTEQYLLNLERETFLQLCGERKTLERIQYMLQKGKPLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U8</accession>
    <name>C6X4U8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="5">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782582.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00985"/>
    <dbReference type="EnsemblBacteria" id="ACU07436">
        <property type="protein sequence ID" value="ACU07436"/>
        <property type="gene ID" value="FIC_00985"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00985"/>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_10"/>
    <dbReference type="OMA" id="CVPMSEY"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="952" mass="105274" checksum="96E46D625E4F1633" modified="2009-09-22" version="1">MNTTQFVSRHISLNDADKKAMLKKIGVSGIDELISQTIPDSIRLEKDLEISPALSEYEMLAHSKELASKNALFDNYIGFGYFNTILPSPIQRNILENPSWYTAYTPYQAEIAQGRLEALLNFQTVVSDLTGFELANASLLDEATAAAEAMHMFFESRTKDQKKAGSIKFFVSDLVLPQTLAVLRTKAEGLGINVIVGNHKSHQFNDTYFGVLLQYPGKNGVVLDYTENIAAYKTHGLQVVVACDPMSLVKLKSPASMGADCAVGTTQRFGVPMGYGGPHAAFFACKEDYKRDIPGRIIGVSQDVYGNRALRMALQTREQHIKRERATSNICTAQVLLAVMAGMYAVYHGPNGLNFIAEQIHFKANALHDGLRVLGYDIVDEPIFDTVKFRIHEEEKNTLRQLMLDHKINLNYFTEGVVSIAIDEAVTLDKLQNLFDAFAQFKDNQSFKLEIKDTIQIPAESLRTDEILTAEVFNKYHTETELMRYIKRLERKDLSLTHSMISLGSCTMKLNAATQMLPISWPEWGNVHPFVPTEQAGGYQTLIKELEKDLAEITGFAGTSLQPNSGAQGEYAGLMVIREYHKSRNELHRNIVLIPQSAHGTNPASAVIAGMKVVVVKNLESGEIDIDDLKAKAEQHSENLSAAMITYPSTYGFFDDNIKDIIAVIHQHGGQVYMDGANMNAQCGYTSPGHIGADVCHLNLHKTFAIPHGGGGPGVGPICVAEHLVKFLPSNPLIKVGDKEAIDAISSAPYGSSLVLNISYAYIKMLGTNGLKTATEHAIMNANYLKEVLAEHFPILYANNKGRVAHECIVDFRQFKSLGVEVADVAKRLMDYGFHAPTVSFPVAGTLMIEPTESESKAEIDRFAEALISIKKEIDEIAEGTADATNNVLKNAPHTEQLVISDGWDKPYGREKAAYPLEWVREHKFFATVARVDEAYGDRNLICTCEPIESYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W2</accession>
    <name>C6X4W2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782596.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00999"/>
    <dbReference type="EnsemblBacteria" id="ACU07450">
        <property type="protein sequence ID" value="ACU07450"/>
        <property type="gene ID" value="FIC_00999"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00999"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032797_0_0_10"/>
    <dbReference type="OMA" id="YNWYGLP"/>
    <dbReference type="OrthoDB" id="382122at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="588" mass="65952" checksum="94818231A33B0308" modified="2009-09-22" version="1">MNKRIQILSILFIGISQVAFSQIAEEKLILDRKREPEVKKIEKKKTSVEAEKNYPPEAKSANPVEYDITNVPAASDFKTSTIQGEDISPKFDAENQNSYFQFGMGNFGKILADGNISTTLENGIEVGADAHFLSTTGLKKEYNWNSKQNLGNVGVYLNSFGDKGKLNVSADYGLNNYNYFGIYALAPEADINLERRTNRISVNGFYDFYSNEILNDVRIKSSFLGDKFDAKESQAEILLNLSKHGVEVPLDDFMMNADLGLNLETLRSEFAILSENASSMLNATVSPQLTFYKGDSYLKLGSDFSFLNSKNSTRTSDQIQENKTYWFPKAELQFAAADEFKFYAGVDGGLKLNSYAEMLEENPYLVSDQELRATETKYKFYFGLRGDIDQSIKYDFRAGYGKINDVMFFRSNGLFDESFTLSRAAYDYANTFSAVYDNGTVSEVRGSIQYFPLANLIVEGELNFEKYDLDNYENIYNKPLLNAAIGAKYSLLEKKLNLGAKAFFRSDATTNSFALTQSVLAPNIYSSVENLDDKVGGFADLNLSAEYKVHKNFSIFALGNNLLNTNYQTFKGYKVLGAQFLGGVKISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z7</accession>
    <name>C6X4Z7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07485">
        <property type="protein sequence ID" value="ACU07485"/>
        <property type="gene ID" value="FIC_01035"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01035"/>
    <dbReference type="eggNOG" id="ENOG5030BB4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130378_0_0_10"/>
    <dbReference type="OMA" id="PVEAGCK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="135" mass="15763" checksum="74CE2E5302EC1CBF" modified="2009-09-22" version="1">MMVFTQKKEIFRKEYPGQLFVLYTAFRSFLRACYRLQFKGHQWKLKATEPVEAGCKLYLGSLTVEEFGDPFAVFKNAFAEKSLAEYDYFLCETVHLSLSPYIDPSGKDMITPFFQFNKMLDAAQLLRERGIEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X523</accession>
    <name>C6X523_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="12" type="ordered locus">FIC_01061</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805796.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01061"/>
    <dbReference type="EnsemblBacteria" id="ACU07511">
        <property type="protein sequence ID" value="ACU07511"/>
        <property type="gene ID" value="FIC_01061"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01061"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_10"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="11">
        <location>
            <begin position="11"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="822"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="438"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="884" mass="99232" checksum="79D44E38299B9C5B" modified="2009-09-22" version="1">MQKEGERLIPINIVDEMKSSYIDYSMSVIVSRALPDVRDGLKPVHRRVLYGMYGLNVFSNRKHLKSARIVGDVLGKYHPHGDSSVYDAMVRMAQPWSLRYPQVDGQGNFGSMDGDPPAAMRYTEAKLKKISDEILADLDKDTVDFQNNFDDSMTEPTVMPTKIPTLLVNGTSGIAVGMATNMAPHNLSESIDAIVAYIDNKEITIDELMKHIIAPDFPTGGIIYGYDGVRDAFHTGRGRIVLRAKINFEEVGNRSAIIVTEIPYQVNKAEMIARTAELVKDEKIPGIYEIRDESDRQGLRIVYELKHDAIPNVVLNMLYKYTSLQTSFSVNNIALVKGRPEQLNLKNIIHHFVDHRHEVVIRRTEFELKKAKERAHILEGFMKVIGTQDDLDKAIAIIRHSSNPAEAKDGLMKEFDLSDLQAQAILDLRLARLTGMELDKIRAEYDEIMNLIRDFEDILANESRRFEIIKAELIEMKEKYGDERRSEIDYSGGEMSIEDLIPDEKVVLTISHAGYIKRTSLSEYKVQTRGGVGNRAATTRDEDFLEYIVAATNHQYMLFFTEKGKCFWLRVFEIPEGSKISKGRAVQNLINIEPDDKIKAYIRTNDLKDAEYINQMNVVMVTKNGTIKKTSLEAYSRPRTNGVNAIEIRDNDQLLGARLTSGDSEIMIATKNGKCIRFPEEKARAVGRGSIGVRGISLEDDDEVIGMIVVNDVENETVLVVSEKGYGKRTAVEDYRVTNRGGKGVITLNITEKTGNLIAIQNVTDEDGLMIINKSGVAIRMSMNEMRVMGRNTQGVKVINLKGNDSIAAIAKVEMDKEVEIEEEEAEGAKPAEVHSDLVEFSGTPQTGDNAISNMGDEKTLRKIEDEEASQNEKSDEDISEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X527</accession>
    <name>C6X527_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805800.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01065"/>
    <dbReference type="EnsemblBacteria" id="ACU07515">
        <property type="protein sequence ID" value="ACU07515"/>
        <property type="gene ID" value="FIC_01065"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01065"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_10"/>
    <dbReference type="OMA" id="EWHHPAF"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="188"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="387" mass="42258" checksum="1C2A2D5D65828BE8" modified="2009-09-22" version="1">MSTEVLEQIKSGKENLASWMNHMHKTPELAMAETNTAQFIAERLREIGGWEIAEGVGKTGIVASMTVGTGQKSIGLRADFDALPIEETNDLPYKSTIPGKAHLCGHDGHTTMLLGAAKYLAETKNFNGTVRLIFQPGEETMEGAPAMISDGLFERFPVDAVFGMHNMPGLELGKFYFNTGKFMAAVDNWEIEITGKGSHGSMPELSIDPIVCGSALVMALQTIVSRNLSPWHSSVVNVGSFQSGLAGNAVPQSAILKLSIRNMDPEDRKMVLDKVRTITKAQAEAFSCKVEIREGVPGTVLVNSDEETHWAAGVAKSVFGDENVFSDAHPYMGSEDFAFMLEKKKGNYCMVGNGETFMVHHPQYIFNQDLLPVGARYWVALAENYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X528</accession>
    <name>C6X528_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1 transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805801.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01066"/>
    <dbReference type="EnsemblBacteria" id="ACU07516">
        <property type="protein sequence ID" value="ACU07516"/>
        <property type="gene ID" value="FIC_01066"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01066"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_10"/>
    <dbReference type="OMA" id="TALFMEN"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="486" mass="51636" checksum="76D37924EFDD3FBE" modified="2009-09-22" version="1">MENSTEQQSFRGNDRLLYGIILGVLAFWMFAQTTLNINVGMAEDLGIEQNMMNIAVSITSLFSGIFIVVLGGLADRIGRVKMIQIGFILSIIGSALVAITPTGTAATPVLMAGRIFQGLSGAAIMPASLALVKAYWDGAARQRAVSLWSIGSWGGSGFCALFGGLVASNLGWRYIFWATVIISVIGFLMVKGTPESKGETKPNYRFDLAGVITFMLSVIALQLLLSKGSDFGWTSLLSLGLLAAFIIFGFIFYRIESGNSNAFVDFNLFRNSTYTGATISNFLLNATAGILIVSLSLVQLGAGLSSQESGLLTLGYAIAIVAFIRVGEKLLQKFGARKPMIWGCLVVGLSIILLMQTQLMTDTYKILAVVAYTLFGLGLAFYATPSTDAALSNLPDDQAGAGSGIYKMASSLGVALGVAVSAAIFTALSGQTGQMEWMNGLINFHGRQDNLALRQGALVALGVNLLMVILAIISIMMTVPKHSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X547</accession>
    <name>C6X547_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01085"/>
    <dbReference type="EnsemblBacteria" id="ACU07535">
        <property type="protein sequence ID" value="ACU07535"/>
        <property type="gene ID" value="FIC_01085"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01085"/>
    <dbReference type="eggNOG" id="ENOG5032XUG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087550_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="322" mass="36239" checksum="2F89005B0744649E" modified="2009-09-22" version="1">MDNLNFNEYTIPMKKKRLLLRMVFDKARAELPEGSITSLAAFLNACFEEKFGYAKNERTFVRYYKSLVVDGRDYVIDVITLDQMSQYLGYKDFSQYAKEMAAGKDEDCKPLKVTVSDGENSVSSISDALSNIVINITNSPVFTLPQFITQHKNGFGVLGVLLLGGFMVNQTGYFKTPETSLPATSPSVLYTNAHNPPITAKEVFSNSTSSDLRAAPVMVLEQARKKECMYWKEDHYEAAFCDEIITGTTLIALDDEQLQSLKKITLPDTLTVQNALGKVWYDKSDNHLEFFTDFGLHPVNGKTLKPITKHMIERHIDGRVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X552</accession>
    <name>C6X552_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805825.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01090"/>
    <dbReference type="EnsemblBacteria" id="ACU07540">
        <property type="protein sequence ID" value="ACU07540"/>
        <property type="gene ID" value="FIC_01090"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01090"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036989_0_0_10"/>
    <dbReference type="OrthoDB" id="941222at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="544" mass="61164" checksum="6D1514B7F274C747" modified="2009-09-22" version="1">MTQISPLVILEILLLAGIIFFQFRSFLATKLKIEKLSTIIPQLKDYSLEKFSFDHYLINTKSQEIINNPSEYDGKSASNENEEISELFAAPNYDVVLVSVNLITLKNGGSTIFNKIKKALNSYLLKNKGSAADFNLMQDVVNRNVDAEDDEISHGLNIPLYLGLMGTMVGIIVGLINLTVSDTVKGDSFDPSAFLIGVAIAMGASFIGLLFTVLNNSSYQRAKKNVELNKNDFYTFLQTELMPVVNASVSSAVYTLKDVVVNFNKDFSSNLTVLNKLFGKSYKALEGQASILDKLEEMDIKQFAAANVKILKELSNATEKIHSFQLYVDSLNTMMSETNRATMSIRELLNGVNNFSDLAVKLEQRVDESAHLLQFATEHITFLKDNSSQVKSLSNDFTDFTEKSMRTLENVSSDVLTNFRKFAEDESEILKNSIKTRPDQFEKLNQLDRLESIENAIGETNTNILHLGEHKLEVQHDRLIKALSEVENSVRNIKISLGRDTGLLPEADREKMLNLVEAQMDYLKSNAFTRLFPYKMVKRRTNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X563</accession>
    <name>C6X563_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain protein (CheY-like)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805836.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07551">
        <property type="protein sequence ID" value="ACU07551"/>
        <property type="gene ID" value="FIC_01101"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01101"/>
    <dbReference type="HOGENOM" id="CLU_933009_0_0_10"/>
    <dbReference type="OrthoDB" id="1893457at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041304">
        <property type="entry name" value="AbiTii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18864">
        <property type="entry name" value="AbiTii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbiTii" evidence="2">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="298" mass="34263" checksum="D19D5B1B0B1FCAAB" modified="2009-09-22" version="1">MIKELITDITYDKIKLSQGLTRAKLIANEIKNDIFSKWLNKELEGYEYQDEYLPSYRKIWSLIELVMEIPGGRFHTFPVVVPEDMDDKFKESVNNHFIIEPISIVEAQIESIDTSKGYITLPPQMIEILAKPFKPQITLYRGVIRKAQREIGKVHYQSVIELTKQKLIDTLMQLNNEFPNLQNKYEMTEENKNKVQHIITNNIYGNSNPLNIATGNNNVQAVNITSLKSEDVEKLKSYGVTEAEIEELKTIIDTKTRDKPKFVEKTMKWLGGVTASVAGRGLYENIPAITDFIHKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X564</accession>
    <name>C6X564_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805837.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07552">
        <property type="protein sequence ID" value="ACU07552"/>
        <property type="gene ID" value="FIC_01102"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01102"/>
    <dbReference type="eggNOG" id="COG4637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507791_0_0_10"/>
    <dbReference type="OMA" id="FVGQNNC"/>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="123"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="550" mass="62462" checksum="14E00F3966D99F8D" modified="2009-09-22" version="1">MKIKAIKIDNFRSIQQTEFTTTDFNIFVGQNNCGKTNFFEAVEFFFNGISKSTKLEDLKFKRETEREIIVEITFTGAIDGVAQMQNVANRTKIENALDGSDIVTFKRSSLLPTKRKMFINGTEVNPGTGFDAALNDFLPKFEYINTKQYYDSVAKYGKTTPIGIMLSGVLTAILQENEQYQQFQAKFRELFEDDNSEIKAEFDNVGNNVKIHLEKQFPDCTKVKFEVSAPVFDDLLKNFETTVDDGIETLAEEKGDGMQRALMLAIIQAYADFRKANEDVGKSFLFFIDEAELHLHPTAQRNLKNVLHILSQTRDQVFINTHSSVFVADNYTSQTIFKVEKNSGETSITSVTDLEKPYVVFELLGGSPADLLLPKNFLIVEGLSEFELLTRVIKRFYSEKPVIQIVKANGDIDQAERSINAIEKLFAPLDTSIYKNRAIILIDQPSAQKQAGVAQFLVTYNHLNINNQFFRLVERDIEQCYPNQPCPTYTNWKKTQAELDAVNGNGDRIITGKKKRQLAKHVGDNITQAQFEADLQICHSALEKCWELAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X584</accession>
    <name>C6X584_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805857.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01122"/>
    <dbReference type="EnsemblBacteria" id="ACU07572">
        <property type="protein sequence ID" value="ACU07572"/>
        <property type="gene ID" value="FIC_01122"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01122"/>
    <dbReference type="eggNOG" id="ENOG502Z88H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043652_0_0_10"/>
    <dbReference type="OMA" id="PSHIGFE"/>
    <dbReference type="OrthoDB" id="384212at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="362" mass="39753" checksum="3C4F7FF9CABD91C3" modified="2009-09-22" version="1">MTKKLIIASFLTGGMGILSAQAESDSVKKLNLSGYAEVYDQFDANRPLNNTRPGFVYSHNRNNEVSLNLAYIKANYSTEKVRATIAIGTGSYMSANYAAEPDVLKNIYEGNIGFKISKKHDLWIDAGILPSHLGFESATGKDNWTLTRSLFAENSPYFETGAKISYTSPSGKWFLSGLVLNGWQRIQRVDGNSTPAFGHQLTFKPNAKLTLNSGSFIGNDKPDSLRQMRYFHNLYAIYQINDKLGVTAGFDIGAEQKEKGSSSYNTWYTPVIVAKYTATDKFSVTARGEYYQDKAGVIIASGTPGGFQTFGYSVNADYAILPNLIWRTEIKNLASKDPIFVHHDGSFSSGSLSATTALAISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X594</accession>
    <name>C6X594_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805867.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01132"/>
    <dbReference type="EnsemblBacteria" id="ACU07582">
        <property type="protein sequence ID" value="ACU07582"/>
        <property type="gene ID" value="FIC_01132"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01132"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022656_0_0_10"/>
    <dbReference type="OMA" id="NNVLMYE"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973609" evidence="1">
        <location>
            <begin position="20"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="47"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="656" mass="73649" checksum="89C65E2703EBEB43" modified="2009-09-22" version="1">MQKIIFAAAMMLLGIPVFAQQDTVQHEREDEIEEIILRSTRSSRTIANTPTRVETIILEEIDEKSNMRPSNVAMILHESTGISVQQTSATSANASIRIQGLDGRYTQILKDGFPSFGNFANGLSVLEIPPLDLKQVEIIKGPSSTLYGAGAIAGVINFISRTPKEKQDLNILINAANTGLYNLGVFSSQRNENLGYSLMALYNDQKEYDIDKDDFTELPNSKEFTIHPKLFFYLPGDANLIVGNAFTTGNRLGGDMQYIKGNASTEHSYFERNTTFRNTATVEFSKPLSETSRVEFKSAYSLFDRTIEVSDYTFKGLNQNYYSDLSWSKTLPNQTLIVGGNYVTDHFKDRLNSTANGLSFFVNTGGAYIQHTWDVSEVLKFENGVRADLVKYGNGLYTESETFVLPKISMLLKLSTKWTSRIGAGLGYKTPTAFTEQTEGFQYQNLKPLIGVTSEKSLGGTADVNFKTMLGDDLDFSINQMFFYTQLNNSIILDGNSTAGYTLANTDKPLYSSGFETNAKLIYKDFLKFFAGYTYTDTRADYIPGDRIVPLVPVHRVNLILMAEKHDQYKTGLEAYYTDVQRLTNGSSTKPYWDLGFMFEKYFGRLSIFINVENFLDTRQSRYKGVVNGSHTAPAFDEIWTHTEGRTFNGGIKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X597</accession>
    <name>C6X597_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component system sensor histidine kinase</fullName>
            <ecNumber evidence="4">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805870.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01135"/>
    <dbReference type="EnsemblBacteria" id="ACU07585">
        <property type="protein sequence ID" value="ACU07585"/>
        <property type="gene ID" value="FIC_01135"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01135"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_106_2_10"/>
    <dbReference type="OMA" id="NIMVEDN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="455"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="652" mass="73576" checksum="F56A84F583BCF45B" modified="2009-09-22" version="1">MKRFTTYTADNFLGLDPVWRLLMLLLISATLSCNSPDKTADAQQSELESQLEEIHKLVYAEPSLARDRSLKILQSISPGTDIKAEIISLKYIGSSYAVETRYAEAIKYYKRALELAEKINLYSETANLNNNLGTIYNEFGNYGAAYIYFIKALENYELAENKEKRSGTLNNIGLTYLSLGNREKALGYFSGALKASQSGKDTILTATILNNIALCNFAEKKIALGLENLKRSISLSEKTRNVYGLCVSYQILGNMYLDEQKTQKAFEAYSTSIGIAERAHLNHLLAVSKIGLARVLLSQNKTGEALRYAEEVMAVSNEKNSQSLKADAHQLLSGIYEKNGNLELSLKEFRDYVKIKEELNNTTVVNQIYDVEVDYLNQLNKMQQLELEKKELAISNKNIWLFFLSLIFLMIFGGAYLIYRNYRGKQKVKLQQTILELTKKKSNAALEAEIEERKRIGRELHDSLGYLLSLAGLNASVLQKRKELPEEKKSELLNSLMESINDAFDEVRTISHNLAPSLLSEQGLKGALKNISDKVNQSNRLKMSFDTFGLHHQLDELVENVLYRTLQEIVNNTIKHADATELFVQIAQDRHQITLMAEDNGKGFDTDSLKTKASFGLSHIKSWIENLNGSIHVDSKIKRGTIISILIPVENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B7</accession>
    <name>C6X5B7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein containing hyalin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805890.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01155"/>
    <dbReference type="EnsemblBacteria" id="ACU07605">
        <property type="protein sequence ID" value="ACU07605"/>
        <property type="gene ID" value="FIC_01155"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01155"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_229214_0_0_10"/>
    <dbReference type="OMA" id="FCVGNIN"/>
    <dbReference type="OrthoDB" id="1551at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044023">
        <property type="entry name" value="Ig_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19081">
        <property type="entry name" value="Ig_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig_7" evidence="1">
        <location>
            <begin position="1942"/>
            <end position="2009"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="2407" mass="256038" checksum="CB2BB6D0BCA6B723" modified="2009-09-22" version="1">MRKLYPILFILIFQNLFSQITAPNGEGYLKQGIIEDAQGKIIRDEATLKKHLQERKLKVEQEHRQMHKGTQTAVEMCTNGGFEQIEKVSGQNYIKNFLHTIGQPPGPTQCQSISNKADAYIPQYTPGMAGLMATSVPSNLIDEFMGDIKAFDQYALKINHTNSSTYGSIVQGKRFKTNNENQLKFNYKAVLQSVYDTSHTDNQAFFKARIINKNGTVVSEFCLVGDEKNCIFTKVPSGGYGYVTLYTEKWQSGILDISAIPNNEEFTVEFMATRCGLGGHFGYAYVDDICMLQSTENFVGSVAIGPLYSICPTLPLTVCGNYTLPNSGGVAATLKTLTLKLNDETGNVVYTTTAPTTLDAVNKKFCFTLLPANFPNVSSGNYNVSVKADFDVATLPGGTGCGGSAGSTQIFASATDSDANPGWDISFLNCTTSCSINVNTALISKCDVNKDGSETFNLTDFNAQVTPNTSGLSFKYFADYASAFNNTNEITSPSSYTTVSTVLYIRVSRDAGCYKIIPVDVQVKNPTANITGVLNVCSGSTELKASSGATYLWSTGETTQNITVSAIGTYSVTVTDSFGCASIATVTIEPSTTAVTPTVEITQPSCFVSTGTIKVTSPAAKYSFDNGATWVTNPVKTGLYPGNYKVIIKTATDCTSYPQEVIIMPVLTGYPSCSSTQPKFCGDTGSITVSNSAAYYSFDNGTTWVTSSTADNLQPGLYSVRTKDISGCISNPQDVRINSNTLGMADYTVVHPACTVRGSITINTPSDFYTFDGGQTWVTNNTLSNLVSGYFSVGIKNNLGCTSYYFESVYLQPFQNSSPQYDVIQPTCGENGTIYISTEADQYSFDNGTTWSTSNMKDLPAGTYRIRIKNAAGCMSQIASVTLYEPTLPLPFHTVVNPTCGNPGSITINTVSDFYSFDGGTTWGTVNTKTLPAGSYQILTKNSIGCKSQSTYAYLTEVKLPKPDITVVQPACASKGSITINSAAAMYSVNGGTTWSTSNVFANLSGNYYNVVTKNAQNCLSETVGVNLNQVYLPEPTYIVVNPSCGNVGSITFTSTATYYSIDGGATWHTTPVFNNLTATVSYNLKVRNATNCVSSGEYVYMSTTNLASPSVTVVEPTCGTPGSITVTTPATSYSFDGGYTWTTSPVKNNITSGYFSVMVKDASCTSTSTSVIINEFRLPDPTYTVTQPICGTGGTINITTPAAKYSIDGGSTWSTSSSFTNLADGYYYIMVQNALGCKSTYAAVYVVIRKYYLPNPDVQIIQPTCLVKGSIKIMTPAAMYSFDGGTTWGTSNEKTDLTSGYYHVVIKNALNCTSDPNSLYVNMTTFYLPQPFIKTVQPTCADSGSITVVSQAAQYSFDNGATWGTSPVLLNPVPGYYNIKIKNAAGCISHTAYTSISKFYLNQPSYATIQPTCAAPKGTIIVQTVADLYSFDNGVTWTTNPVKNNLNSGSYNILIKNSSGCVSQSAYVYISSAPVIPAKPVATVTQPSACDATDGSITITSPGVSYTFNDGASWTTDPVKRNVGAGTYILRVKMNSYSCESVSTVVILDSGQSIAAPAVSVVQPTCSVATGSITVTTAAATYSYDDGLTFVYSNTKSGLSPGVYKIKIKNAAGCLSVAATATVTAQAPLPEPAYTVAQPNCATALASITISSPAAEYSFDNGLTYGTQNTKTGLAPGSYSLMIKDAAGCFSNVAVATVQPQPSTPAAPQISVTAPSGCAAVTGTVAVISAAALYSFDDGATWTSQASANLAPGVYQVRIKLSASGCVSPPTTATVDPPPNAPALPLFLVSQPVSCVNPFGIITITSTEHQYSFDGGSSYSSTAVSAPLSPGNYLVKVRNSAGCESGSVSVTINVPADMPKKPTASVLQINCNQPFGEIAFNENESQYSIDNGATWHNSNIFKGLTPKTYLLKTKNTLGCISTATSVTINNFSNPTPKPLANAVQNFCIQQNPTVAHLTASGTSTKWYSAETGGTPLPDSTALIGGATYYVTQTLSSCESERLPVLINIYNTAAPTGPAAQVFCVSQMAKVSDLNGTGNQIKWFSTAMSSVPLSANTLLQDGATYFGTQVQNGCESVSRLEVKVSLVTTNIPAVDFSAPAICSDENGTKKVDLTQYQSAIVPNSGLYTYEYYTVSQVRIDDPTKALLPAGSNLIYVEIKSAVGCSAKVKLTVQINASPVVNVPANAVFCPESSVLLDAGSLAAGSTYTWMYNGVFESSLQTIKASKVGTYVVTVTNTSGCTTTKTISVKEVELPVITLIKIENTSVQIIATGSGTLEYSIDGSTWQSSNTFHNVPVGNHLAYVRSGLQPCAIAIKAFTIFKITNVFSPNGDGVNDNWMIEGIENYPESHVRVLDRFGSVVLDRKVKGIFSWNGQHAGRNLPTGNYWYYITVSDGRILSGYVTLKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G7</accession>
    <name>C6X5G7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01207"/>
    <dbReference type="EnsemblBacteria" id="ACU07655">
        <property type="protein sequence ID" value="ACU07655"/>
        <property type="gene ID" value="FIC_01207"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01207"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038153_1_0_10"/>
    <dbReference type="OMA" id="LDTQYFH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026889">
        <property type="entry name" value="Zn_Tnp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14319">
        <property type="entry name" value="Zn_Tnp_IS91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS91" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="342" mass="38884" checksum="7055A5BBC453D4E5" modified="2009-09-22" version="1">MQARSNGGSVAEVLRKINLSSQNFSVHQEKTLRALSNCRTAALGGHIDACDGCGNLSISYNSCRNRHCPQCQGHKKEEWIQKREQDLLPCTYYHVVFTLPEELNGLAISQPQLIYKALFEAAWATLNQFGKNKGIQLGMIAILHTWGQNLSLHPHLHCIVPGGGINRQGKWIRKVRTDKYLFSVKAMSKVFRAKFVASLRACGITDQDLMDKLFAKNWVVYAKRPFGGPKQVIEYLGRYTHKVAISNHRIKEVTDEQVRFSYKDYRKGGAKKEMTVSNQEFIRRFSLHILPRRFVRIRHYGILSSSWKRGKLQALQSDLKIRVTTAKPKLCSGNAGAARRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R2</accession>
    <name>C6X5R2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806035.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01302"/>
    <dbReference type="EnsemblBacteria" id="ACU07750">
        <property type="protein sequence ID" value="ACU07750"/>
        <property type="gene ID" value="FIC_01302"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01302"/>
    <dbReference type="eggNOG" id="COG3797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106303_3_0_10"/>
    <dbReference type="OMA" id="NLIFMFP"/>
    <dbReference type="OrthoDB" id="1382593at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="174" mass="19602" checksum="56043015027FB629" modified="2009-09-22" version="1">MKFCAFLRGVNVKGTNMKMADVCKVFADAGMTDVSSVLASGNIVFSSERPAAEIKPVLEKAMSAHFSYEAFLFIKNESEVKSIFQQNPFKKDENLHVYVFIGLVETEQLLLEEFKNSIKTEHEKGQITAETFYWQVPKGDTLGSSFGKVLGKKALKNKITSRNINTFEKILKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U5</accession>
    <name>C6X5U5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806068.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01335"/>
    <dbReference type="EnsemblBacteria" id="ACU07783">
        <property type="protein sequence ID" value="ACU07783"/>
        <property type="gene ID" value="FIC_01335"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01335"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071512_0_0_10"/>
    <dbReference type="OMA" id="FGQYDHV"/>
    <dbReference type="OrthoDB" id="1730305at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="30511" checksum="82F7556DBE2568AC" modified="2009-09-22" version="1">MKKLAKFILNKIPRPMLINLSIFLRPLIYQFFKGDRFTDPIDGKSYRKFLPYGYGKQRENALSPGTLSLERHRQMWLYLKNETDFFTKNYKVLHIAPEQEFLRRFKKMKNLDYISADLFSPIVDVKADILDLPFEDESFDIVFCNHVLEHIEDDRKAMSELFRVMKKGGWGIFQVPMKNSLEKTYEDFSIKDPKERQKHFGQYDHVRWYGTDYFSRLKEAGFQCNINYYSKQFSDEERRRFGLMENEILPVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y6</accession>
    <name>C6X5Y6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01376"/>
    <dbReference type="EnsemblBacteria" id="ACU07824">
        <property type="protein sequence ID" value="ACU07824"/>
        <property type="gene ID" value="FIC_01376"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01376"/>
    <dbReference type="eggNOG" id="ENOG5033ZMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127590_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="137" mass="16369" checksum="FD589493AF9C8EDE" modified="2009-09-22" version="1">MLQMMQKSGHAWKEKAISELFGPLCFQLSRTQSAFNRYKAKNLFLEAEVLKNSNQKIRDLLLEKSYLIPPDLTEHAKNLVEHYDVWLEEFNRLREGENQAQDKNFVFVGPKGFPFPKTAEKKFREKYEELWQAMYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z2</accession>
    <name>C6X5Z2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01382"/>
    <dbReference type="EnsemblBacteria" id="ACU07830">
        <property type="protein sequence ID" value="ACU07830"/>
        <property type="gene ID" value="FIC_01382"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01382"/>
    <dbReference type="HOGENOM" id="CLU_3396631_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="31" mass="3838" checksum="8E40315AEF39A1AE" modified="2009-09-22" version="1">MSINFGVYVLFLHFKHEILNLKFLFYIYLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X640</accession>
    <name>C6X640_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.38" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806163.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01430"/>
    <dbReference type="EnsemblBacteria" id="ACU07878">
        <property type="protein sequence ID" value="ACU07878"/>
        <property type="gene ID" value="FIC_01430"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01430"/>
    <dbReference type="eggNOG" id="COG1212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065038_0_1_10"/>
    <dbReference type="OMA" id="FMATCAK"/>
    <dbReference type="OrthoDB" id="1345588at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="248" mass="28042" checksum="A0E7849DBDE7C20E" modified="2009-09-22" version="1">MKIIAVIPARYEASRFPGKLMEMLGDRTVISTTYQNVVDTGLFNEVFVATDSEIIFNEITERGGNAVMSGQHETGSDRIAEVVQNIDCDIVVNVQGDEPFLDTEPLKQLISVFDTDLDQNISLASLKIKINSITDIENPNHVKVITDHEGFALYFSRSVIPFPRAIHPDVEYFRHIGVYAFRKTALLNFSRLPMRPLEISEKIECIRYLEYGMKIKMIETDFVGVGIDVPEDLEKARAILSARNNTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X678</accession>
    <name>C6X678_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01468"/>
    <dbReference type="EnsemblBacteria" id="ACU07916">
        <property type="protein sequence ID" value="ACU07916"/>
        <property type="gene ID" value="FIC_01468"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01468"/>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_10"/>
    <dbReference type="OMA" id="HPYYHLY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="6">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="5">
        <location>
            <begin position="161"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="382" mass="42444" checksum="D181E0248F1060AD" modified="2009-09-22" version="1">MPHEEKLEVVKKGKQFSIGIPKETCLNERRTCITPDAVQVLVQNGHEIIVEAGAGEGSFFTDLQYSEAGAQITPDAQEAFRQDLVLKINPPTSEEIDFLKPCAYLISALQINLRDKEYFRQLAEKKVNAIAFDFIIDEYKQLSLVRLIGEIAGNISILYAAELLALSNGLMLGGITGVRPTEVVIIGAGIVGEFATKAALGLGASVKVFDNSLSKLRRLHMMVDGRVPTSIIDPKELSKSLRRADVVIGAFSKISLSPIVTEEMVMQMKKGSVIIDVTIDNGKVIETSELTDMENPYIVKHGVIHCGLPNLTSKMPRTTTKAISNFFLSYLLNYDEEGGFENMLVRKNEIKQSLYMYKGRHTKKIICDRFGLNYHDINLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C1</accession>
    <name>C6X6C1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01512"/>
    <dbReference type="MEROPS" id="T03.001"/>
    <dbReference type="EnsemblBacteria" id="ACU07959">
        <property type="protein sequence ID" value="ACU07959"/>
        <property type="gene ID" value="FIC_01512"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01512"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_0_3_10"/>
    <dbReference type="OMA" id="KATKNMF"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="574" mass="62322" checksum="9720F5A6518B3781" modified="2009-09-22" version="1">MILFLCTFDEISFMKKLALLLLFSYGIVFPQFTNINIVKEIRTKDKGLVVSAHPLASEAGARIMKMGGNAFDAAIATQLALAVVYPQAGNIGGGGFLVGVKNNGEKFTIDFRETAPGKSSRDMYVDKNGQANTDLSQNGHLAAGVPGSVAGFFATLKHAKLPMEQLIQPAIDLAEQGFSVTGREAALLNGQRQFFDRHNQTKTVFQKNEPWKQGDILIQKDLAQTLKLIQANGEKGFYEGRTAALFSAEMKRGKGIMTEQDLRNYKVVERKPLAFTYNENEIVSMPLPSSGGILLAQMLKMSSFENLAQYPHNSAEAVQIMIEAERRAFADRAEFMGDPDFISDQTQMLISDTYLKNRWKSFNKNLATPSAEVGKIVAQPKESTETTHISIIDKEGNAVSVTTTLNGLYGSKVVVSGAGFFLNNEMDDFSVKPGVPNMFGAVGGEANAVAPGKRMLSSMTPTIVLKNGKPYIIVGTPGGTTIPTSVYQTIVNIIDFKLDPNMAVNAPKFHHQWLPESVLAEDNLPATTVSALEKLNYKFVNTAQIGRTELIVIDDNGNATAVADGRGDDSVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C2</accession>
    <name>C6X6C2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806245.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01513"/>
    <dbReference type="EnsemblBacteria" id="ACU07960">
        <property type="protein sequence ID" value="ACU07960"/>
        <property type="gene ID" value="FIC_01513"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01513"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_19_1_10"/>
    <dbReference type="OMA" id="HWHASPR"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="320" mass="35998" checksum="22E5DA2A9290777F" modified="2009-09-22" version="1">MNSQTEKILITGALGQIGTELTNKLVEIHGAENVIASGLDRWDKNLTSAGFYERMDVSNTQLVRQVVKDYEITTVYHLASLLSGTSEKQPLFAWRLNIEPLLNFCEMAKDGMLKKVFWPSSIAVFGKGIPKENVGQDVVLNPTTVYGISKMAGEKWCEYYHDKFGVDVRSIRYPGLISWKTPAGGGTTDYAVEIFYEAVEEAKYTSFISEDTAMPMLYMDDAINATLKLMQAPKEDLTVHTSYNLGGLSFTPKQLAEEIKKEMPDFTIDYKPDFRQEIADSWPASIDDSIAKKDWGLTYDFDISAMTKDMLRNLKVKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C6</accession>
    <name>C6X6C6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsR</name>
        <name evidence="5" type="ordered locus">FIC_01517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806249.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01517"/>
    <dbReference type="EnsemblBacteria" id="ACU07964">
        <property type="protein sequence ID" value="ACU07964"/>
        <property type="gene ID" value="FIC_01517"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01517"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_2_0_10"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="100" mass="11488" checksum="CF64AE574EA7AA47" modified="2009-09-22" version="1">MAIDDMAKQASAGGESEVKFLTPLDINTKTDKKYCRFKKYGIKHVDYKDANFLLQFVNEQGKILPRRYTGTSLKYQRKVSAAIKRARHLAMMPYVADLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZA9</accession>
    <name>C6WZA9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782134.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00529"/>
    <dbReference type="EnsemblBacteria" id="ACU06987">
        <property type="protein sequence ID" value="ACU06987"/>
        <property type="gene ID" value="FIC_00529"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00529"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_6_1_10"/>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="81" mass="9379" checksum="F7808003C4BC5F64" modified="2009-09-22" version="1">MLNKIITFPLVALIKIYQWFISPLFPKNCRFEPTCSSYMVEALRVHGPVKGLWLGTKRIARCHPWGSEGYDPVPPKTMHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE0</accession>
    <name>C6WZE0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782118.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00513"/>
    <dbReference type="EnsemblBacteria" id="ACU06971">
        <property type="protein sequence ID" value="ACU06971"/>
        <property type="gene ID" value="FIC_00513"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00513"/>
    <dbReference type="eggNOG" id="ENOG502ZC3P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432222_0_0_10"/>
    <dbReference type="OMA" id="HRMITHN"/>
    <dbReference type="OrthoDB" id="1443661at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="189" mass="22358" checksum="64CEB50E3E6C85BB" modified="2009-09-22" version="1">MKISAPTKGLIIAILTVLFAFGIYFLFLAKKDYYLVDNPTENTYYFNLNNGVENTITAGQQFPIDLRKGRNSVKVFDGKKKLLYDSVFVVKKDRGLLNIAHQDYYINEQFYGYGLNKDSLIMARKSTVIDNKNYVNAPKLFNKLYTEDFYYNIDEDYDKVIKNVQKVESRTKIFRKVDFLNYYKEYYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG5</accession>
    <name>C6WZG5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781647.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00022"/>
    <dbReference type="EnsemblBacteria" id="ACU06500">
        <property type="protein sequence ID" value="ACU06500"/>
        <property type="gene ID" value="FIC_00022"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00022"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137972_0_0_10"/>
    <dbReference type="OMA" id="ANCCKTT"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="163" mass="19139" checksum="F9387E2F659E2132" modified="2009-09-22" version="1">MNLESYKSQATLKQKEHRKFLEGLKKKVPKNLDYSAQQAHDEVFDRIDCLKCANCCKTTGPLFTDKDIERISRHLRMKPADFEVKFLRTDEDQDKVLKNLPCHFLAADNTCSIYEVRPKACREFPHTDRKKIYQINHLTIKNTLICPAAFEVVERLQKILEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH5</accession>
    <name>C6WZH5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781657.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00032"/>
    <dbReference type="EnsemblBacteria" id="ACU06510">
        <property type="protein sequence ID" value="ACU06510"/>
        <property type="gene ID" value="FIC_00032"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00032"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_10"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="406" mass="45407" checksum="4747559A1A4FA40C" modified="2009-09-22" version="1">MFDIQNIRSQFPILSQKVNGKPLIYLDNAATSQKPLSVLDSWQKYYAEINANVHRGIHTLSQLATEEMELSRRKIQKFINAKHDFEVIFTKGTTEGINLIAYSLTNLIKKDDEILISHLEHHSNIVPWQLLCERTGAKLKVIPMDADGILQLDFLDENINERTKIVSINQVSNALGIVNPVEEIIRKTRAQSDAYIVIDGAQSAPHFKIDVQQLDCDFFVFSGHKMYAPMGTGILYGKERILREIPPFHGGGEMISVCSFTKTTYADLPFKFEAGTPNVGGNIALGAAVDFIEGIGHEHLQNHENALLEYAQRKLLELEGLRIYGEKARRTGVVSFNLEGVGISSDVGMILDKMGIAVRTGHHCTQPIMEYFEIAGTVRASFAVYNTFEDVDLLVEGVKKAQRMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH6</accession>
    <name>C6WZH6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781658.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00033"/>
    <dbReference type="EnsemblBacteria" id="ACU06511">
        <property type="protein sequence ID" value="ACU06511"/>
        <property type="gene ID" value="FIC_00033"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00033"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_10"/>
    <dbReference type="OMA" id="MNTHADR"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="16938" checksum="9361E2E8C818ECEA" modified="2009-09-22" version="1">MLKVGDRLPEFEGVNQDGETINSNDFAGKKLVVFFYPKANTPGCTAQSCDLNNHFSMLNKEGYQLLGVSADSVKAQKKFHQKFGFQYPLLADEKREVIEKFGVWQLKKFMGREFMGIVRTTFIFDENGICTRVIEKVKTKEAAKQILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH8</accession>
    <name>C6WZH8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response Regulator Receiver Signal Transduction Histidine Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781660.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00035"/>
    <dbReference type="EnsemblBacteria" id="ACU06513">
        <property type="protein sequence ID" value="ACU06513"/>
        <property type="gene ID" value="FIC_00035"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00035"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_10"/>
    <dbReference type="OMA" id="NGWEFRA"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="116" mass="12957" checksum="0B7B57FAD2C6C303" modified="2009-09-22" version="1">MSILVVDDNKDICTLIENILLSEGYDVQTCCNPLEVSTIIKDTRPALIITDMLMSGFDGRTLTKEVKADPETEHIKIMMMSAHPDAESISRSIGVDDFLTKPFEIDDLVNKVEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN7</accession>
    <name>C6WZN7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase T</fullName>
            <ecNumber evidence="5">3.4.11.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aminotripeptidase</fullName>
            <shortName evidence="5">Tripeptidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Tripeptide aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepT</name>
        <name evidence="9" type="ordered locus">FIC_00097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves the N-terminal amino acid of tripeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5 7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase M20B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781719.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00097"/>
    <dbReference type="MEROPS" id="M20.003"/>
    <dbReference type="EnsemblBacteria" id="ACU06572">
        <property type="protein sequence ID" value="ACU06572"/>
        <property type="gene ID" value="FIC_00097"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00097"/>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053676_0_0_10"/>
    <dbReference type="OMA" id="GHNFHGK"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00550">
        <property type="entry name" value="Aminopeptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="8">
        <location>
            <begin position="218"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="419" mass="46859" checksum="0B4311588038C940" modified="2009-09-22" version="1">MKTIEFDLEWKLKLQNRFITYAKMYSTSDPESETTPSTERQWQIARYLYDEMVQLGLSDVSIDDNGYIYAYVPSNLEQDDEPVVGFIAHYDTSPDFNGENVKPQIWDDYDGGDLVLNKETGFTLSPDKFKSLKNYVGKTLITTDGTTLLGADDKAGVAEIVTAAEFLLAHPEIKHGKIAIGFTPDEEIGRGAHKFDVAKFGAEWAYTMDGSEVGELEYENFNAAAAVVKIHGLSVHPGYAFGQMVNASLLAAEFIKMLPENETPSTTKGFDGFYHLTDLKSDVSEAIIQYIIRDHDEEKFENRKKVITEKVAEFNSKFGEGTAEIEIKEQYRNMKQQFEGKMHIIDIAEQAMKDANIAPKIKAIRGGTDGAQLSYMGLPCPNIFAGGINFHGPYEYVALESMEKAVKVIINIARAVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP4</accession>
    <name>C6WZP4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781726.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00104"/>
    <dbReference type="MEROPS" id="C40.004"/>
    <dbReference type="EnsemblBacteria" id="ACU06579">
        <property type="protein sequence ID" value="ACU06579"/>
        <property type="gene ID" value="FIC_00104"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00104"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_9_2_10"/>
    <dbReference type="OMA" id="KFIHAAT"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970472" evidence="2">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="89"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="227" mass="25244" checksum="E2AC2EDFFAC3F22E" modified="2009-09-22" version="1">MKKRVLFYLVAITSAVSLQSCVSNYVVSTPTTYNKEYKSDAKLASLDQKKLETAKAQLLTNFHDEKLAATRTMEATIRKDEIAKTLHFTKKIDDILAEAETYLGTPYKYGGMTRRGIDCSAFVLSVFGTVTGMTLPRVAASQAQEGEKIDKEDLQKGDLVFFSQGRGRISHVGIVEEVSNEGVKFIHAATSKGVMISSLNDSYWGPKFRFAKRVLSLDTFEKNFANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZV8</accession>
    <name>C6WZV8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Catalase</fullName>
            <ecNumber evidence="10">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00168</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00168"/>
    <dbReference type="EnsemblBacteria" id="ACU06643">
        <property type="protein sequence ID" value="ACU06643"/>
        <property type="gene ID" value="FIC_00168"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00168"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_10"/>
    <dbReference type="OMA" id="PIDIFDC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="451" mass="51417" checksum="3FF3FF1BFB2CCFC8" modified="2009-09-22" version="1">MMDASHKLNHEPNAVQATNSAGFMVNENIAEAVRRKIPERVTNVKGTGAYGTFIVTQDITKYSKAKIFAEVGNQCRVFVRFSAMHAEKGTCDSDRDVRGFALKFYTEEGNWDLAGNNMPVFFVKDATNFPGLMRSQGRDFHTNMKSATAMWDFYSLHPETLHQLLMLMSDRGTPSGYRHMHGFGTHTFSMINARNERFWVKFHFKAKQGIKNLKSENIVKSDFAHEDLVKAIETKNFPKWSLYIQVMTQEQVKNSRWNPFDVTKVWLHDEFPLIEVGELELNEIPKDYFTHVEQAAFSPANIIPGIGFSPDRLLQARLFSYTDAQRHRVGINAKELAVNQSSAKNSVQHFEDEVRNAATANLTNIYENEDDHYTQPGLFYTKALNAEQRETMIQNIVEAMRDISGPTKHVVINRQLCHFFRANIELGMKIATGLQVNIDANMMSHSFTAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY4</accession>
    <name>C6WZY4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6089 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00194"/>
    <dbReference type="EnsemblBacteria" id="ACU06669">
        <property type="protein sequence ID" value="ACU06669"/>
        <property type="gene ID" value="FIC_00194"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00194"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071588_1_0_10"/>
    <dbReference type="OMA" id="RYTFTDN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045743">
        <property type="entry name" value="DUF6089"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19573">
        <property type="entry name" value="DUF6089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6089" evidence="1">
        <location>
            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="266" mass="30070" checksum="44E337F6E01105A6" modified="2009-09-22" version="1">MSNLVGDIGRTGYVLQKPFGDFAKYGLPFYGGALYRMNFNPYQTLRLNIGYSHIQFSDGHAKEKYRNMRKLWGTNSIVEADVIFEYNFLPVNDEQKSMLSPYLFGGIGAMFANTPQIALEHDFRRVGGTAQTPTSSEDFETRQGQYQSVSQISMAIPFGVGLKYKFNYNWALFGEFLFRPTFSDSIDYSVIDENNVQVSYNKDLLASGSTTKSLLQETPYREVAEARVADFMQNRAIGNINSKDWVNSITLGVSYSFGRPPCYCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY6</accession>
    <name>C6WZY6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Outer membrane protein assembly factor YaeT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00196"/>
    <dbReference type="EnsemblBacteria" id="ACU06671">
        <property type="protein sequence ID" value="ACU06671"/>
        <property type="gene ID" value="FIC_00196"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00196"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007664_3_0_10"/>
    <dbReference type="OMA" id="IFMPAFG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="71"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="323"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="874" mass="98511" checksum="4606D3AEB94F389C" modified="2009-09-22" version="1">MIISIKNEDSAKQANSLKKIYKRKLARQKMKFKFLPIIMFVASAHFYGQITPEQTPQDNNPVYAQNEAGTYILKDIVVDGVKKYTPAQILRFTGLNKNESVEIPGQKISNAIKKLWETQSFSEVEVFIQSIEGEQIVLRFNLQDLKDLGEVKFTGKGINKSKSEKLAKDNNLKPGTKITQNLISTLQTNIPQEYVKKGFADAKVSIQEKVNAQDPELVDWTIEVDRGRKVKISHIEFEGNESVSDKKLRNKAFKDTKQKRFGIKGILKPSKFIEEKYEEDKNNLVNYYRSLGFRDAKIVSDSVWRNPKNDFEINVKLNEGKKYYIGDINFLGNAAFSTDYLQKVLGYKTGDIYDAVGFNKKVGEDGGKEDDSDIKSIYMNNGFLFSNVTPIEKSVEGDSINLEIRINEGEKASWNRVTWSGNTTTHDHVVLRSLRTKPGSLFAKSDIKRTYFDLAGMQFFDPQQVGQQLSPNPQDNTVDIHWTLVEKGSSQVQLQAGYGGGSFIGTLGLTFNNFSLRNFLKFKDFKPVPQGDGQTLSIQAQAGQYFQNYGISFTEPWLFGTKPTALSVSVNQSLVRYSDQFGETQKLNIFSASAGLNRLLRWPDDYFSLYTGIQFQSYDFENYPFQFGNETEYNGSAKNFSFNIGLSRNSAGLDPIFPTQGSNVEASVKFTPPYSLFSDKDYSSMTNVEKYKWLEFYKIKIKADVYNTVVGKLVLRSTAEMGFLNGYNSELGAPPFERFYVGGTGLFGGRYDGRELVPLRGYENASSTGGTIEDVTPYGGATIYNRFALEVRYPISMNQTAKIYALTFLEGGNAWNSFGNYNPFQLKRSAGVGVRVYMGAFGLIGFDFAYGFDKTILGTEPAGWKTHFLMNQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ9</accession>
    <name>C6WZZ9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized transporter PG_1411</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAE transporter (TC 2.A.81) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781831.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00210"/>
    <dbReference type="EnsemblBacteria" id="ACU06684">
        <property type="protein sequence ID" value="ACU06684"/>
        <property type="gene ID" value="FIC_00210"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00210"/>
    <dbReference type="eggNOG" id="COG2985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035023_3_1_10"/>
    <dbReference type="OMA" id="AMWLIRL"/>
    <dbReference type="OrthoDB" id="1458740at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006512">
        <property type="entry name" value="YidE_YbjL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06826">
        <property type="entry name" value="Asp-Al_Ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01625">
        <property type="entry name" value="YidE_YbjL_dupl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="9">
        <location>
            <begin position="203"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="9">
        <location>
            <begin position="290"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="562" mass="61836" checksum="495D1D584D48F2C8" modified="2009-09-22" version="1">MFDWLQTLLLPVENPTVTQSIVVIMLAVGSGIFFGRLKLGKITFGVSAVMFTGLLLGHFGYRIDAGILDFIREFGLILFVYGIGLQVGPSFFSSFRNEGLKFNLLAVATVLFGGLITVVLFKVTGLNIEDLVGIMSGSVTNTPGLGAAKNTIEEMQATFPDRAFNDPTIGYAITYPLGVFGIIGTIILSKLILKIDLETEMRNFRMSKINRELPLVHKKMRVTNPVFFGKTLHQAISESGLEIVVSRLKHSGSAAVQSPTSDMYLRDRDVLMLVGLEKDLDEFIALAGRPSTDLFIESDSDIHNRNIFVTKSSAIHKKLSELDLYNNYDLKVTRVFRAGREILPRPSLELFYGDKLRVIGSKEAIAEVEKIIGNSEKKLLEPDFLSLFGGLLLGVILGSIPIAIPSLPVPIKLGFAAGPLIVALLISRFGGISFIHSYINNGAIYFMKDFGICLFFAAVGIHAGDGFYDNFIAYNGWNWLLFGSAITFIPLLFMVVIGRFMMKINYLQLAGIMSGSYTDPAALAFSTNYLDSDIPVQSYAQVYPLVTIFRIFVASLLILIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X002</accession>
    <name>C6X002_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00213"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06687">
        <property type="protein sequence ID" value="ACU06687"/>
        <property type="gene ID" value="FIC_00213"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00213"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_10"/>
    <dbReference type="OMA" id="STDQEHG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="12"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="523" mass="57632" checksum="62D00982E12F5DD5" modified="2009-09-22" version="1">MFIVALYTNKGEDFIDNVRKTVVKEQIGGLILMQDDAAREINLVNEFQQKSKVPMMIGMDAEWGVYQRIAAAYKFPWAMTLGAIQDKNLITEMAAKIAEDCQRMGVNWDFAPVVDVNTNPQNPIIGNRSFGSEVSNVVGSAMAYSNGLQQNNVLAAIKHFPGHGDTDTDSHLDLPVVSHPLKRLEAVELAPFKALMDKGIGGVMVAHLYIPALEKEKGVPASISKNIITGLLKEKYGYKGLIITDALNMGAVAKRYKPGELDALAFKAGNDIMLFSEGVEEGKRLIQLAIDKGEISQNRVEESVKKILLTKYFLGLEKYKPRNPENVNYDLNNESHQKLVQNLYANALTLLKNDKKLLPLSCDETYYYVPLEEAPYQDFADHLNLNASVVVKKASEISTIPANSKVIVGFHKDNSTAYKPYKISDESKKTLSELSKKHQVILNVFASAYALKDIDISKIPAVLVAYENNGDSMKATAKALTGSTEISGRLPVLVHENLKPGMGINLKATSATEIKKGNKTLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X011</accession>
    <name>C6X011_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781843.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00222"/>
    <dbReference type="EnsemblBacteria" id="ACU06696">
        <property type="protein sequence ID" value="ACU06696"/>
        <property type="gene ID" value="FIC_00222"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00222"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079899_2_0_10"/>
    <dbReference type="OMA" id="QERIWAN"/>
    <dbReference type="OrthoDB" id="1405516at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025634">
        <property type="entry name" value="DUF4292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14125">
        <property type="entry name" value="DUF4292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973429" evidence="1">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="29490" checksum="C4B71ABFA1F00BEC" modified="2009-09-22" version="1">MKKYIVLIAISLGLSSCKTNSATTATPAGPAVNTAGSTAFYKAITKKADFQQVKINSRVDVETGSFIPTLDATIYIENGQKVWMNMIAVFLNVGRGIATPSGIQGYEKWNKTYIESDFSYLNRMLNVNFIDFNSLQNLLIGKTFIPVNEKDFTLTQNAQGSVLTSSKNLKFTNNGSVSEYAVSLQYSPQLDLTTVVLNNAKSAERLEVTYSNWVTFENMRLPKNVKINIKGTKSSQIMLENTKFESSKMDTPYSVPNNYTKTEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X016</accession>
    <name>C6X016_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase, M16 family</fullName>
            <ecNumber evidence="6">3.4.24.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.56" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00227"/>
    <dbReference type="EnsemblBacteria" id="ACU06701">
        <property type="protein sequence ID" value="ACU06701"/>
        <property type="gene ID" value="FIC_00227"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00227"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306466_0_0_10"/>
    <dbReference type="OMA" id="LAWVNKY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970496" evidence="3">
        <location>
            <begin position="21"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="58"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="149"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="262"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="592"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="787"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="974" mass="110299" checksum="EF8630A4B3FDA1C4" modified="2009-09-22" version="1">MIRKKFLMLFAVGILFTAQAQDYQWKEAKSGGYTYKYVTNDPTQARFYTLQNGLTVILSPTKKDPRIQAYIATKAGSKTDPATNTGLAHYLEHMLFKGTDKYGSLDWAKEKAELDKIDALYEQYNKSKDEVKRKAIYKKIDSVSGVAAKYAIANEYDKMMTAMGAQGTNAWTNFEETVYTDDVPSSSLDRYLAVQAERFRNPVLRIFHTELEAVYEEKNRTLDTDSRKVFETLFATLFKNHNYGKQTTIGTVEHLKNPSLVEIRKYFNNYYVPNNMGVILSGDFNPDDAIAKIDRAFSYMKNKPVPKYTFQPEQAMTAPIIKEIVGPDAENLTIGYRLPGNKDKDVLLADLVGSILTNGKAGLLDLNLVKKQKLLRASAFTYTLQDHGILYLSAAPTTGQTLEEVQTLVLSEIENLKKGNFDVDLIPSIVNNIKKEKIQSLERYGDRASMLQSAFNAELDWKDQVAYVDDISKIKKEDVVAFANKYFGNNYVAILKKKGENKNPQKIEKPSITPVETNPDKQSAFVKMVNEMPSTPSEPVFLDFNKDIQKSKLGKAEVLYVPNTENQLFRLRYRYKVGTLNDPKQSLASQYLQFLGTDKKSSEEISKEFYKIASSFNVSTGEEYTMVTIEGLQENFDKAVKLYEDLVMNAKPDETALAALKARIAKSRKDAKANKGAILQGLTSYAMYGPKNKFNNTLSDAEINAVTAQELVDRMKNLNNYEQTVIYYGPEPIKNLTAKLGTMHKVPATFASAGPLKTFKQLPQTRTQVLFTDYDMVQAETRWIRNTENYDAAKTPMVMVFNNYFGGGMGSVIFQTIRESKALAYSTYGLYVQPQKKDDQYYMMSYVGSQADKFGDAVGAMNELLTTMPQLPVNLDLAKNSVKKDIQTERVMQDDIIFRYLAAQQLGLKDDIRKQLYTNVDKITMNDLKNFHTTNISGKPYTYALVASEKNMRMDDLKKIGEVKKITLEELFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X021</accession>
    <name>C6X021_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781853.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00232"/>
    <dbReference type="EnsemblBacteria" id="ACU06706">
        <property type="protein sequence ID" value="ACU06706"/>
        <property type="gene ID" value="FIC_00232"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00232"/>
    <dbReference type="HOGENOM" id="CLU_1303101_0_0_10"/>
    <dbReference type="OrthoDB" id="1972507at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="220" mass="24376" checksum="2FED277CEE88B3DE" modified="2009-09-22" version="1">MAKVHPIIKVEGKIGDRIYYTLNGKPVARRIAKKRRGPKTKGEQKKALFASEFGKASAAGRVLREALGEIYTRLNDRYLYQRINKIMALLRSADVSEPGFRTVAGGLATDEGQKLLADFDFHQKAVVFPRILTANTVPGKLQLHFSDDTTKPVTVLELQINFDNRAYRSHEHAFPKGVQAGPVTLKKRFRRKKGFTDLVFISGPGFLQAVGLGGRGKGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X034</accession>
    <name>C6X034_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ordered locus">FIC_00246</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00246"/>
    <dbReference type="EnsemblBacteria" id="ACU06719">
        <property type="protein sequence ID" value="ACU06719"/>
        <property type="gene ID" value="FIC_00246"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00246"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_10"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="481"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU06719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="595" mass="68280" checksum="FD852403FF6D9426" modified="2009-09-22" version="1">MITMNIKNIIELKIAEVIQNVFQIDDLNHKHNLSLEVQQNKSGFEGDFSVVTFPLVKIVKKTPDHVATELGDALFTQADFVESFNVVNGFLNLKIRNAFFINNFYSAKQNLDQVDAKNQTVMIEYSSPNTNKPLHLGHIRNNLLGYSVAEILKADGYNVVKTQIINDRGIHICKSMLAWQRYGEGSTPASTSLKGDKLVGNYYVEFDKTYKKEIAELVAQGKSEDEAKKEAPIIKEAQQMLLSWEKNDEKVRELWKEMNTWVYAGFDQTYKRLGVDFDQVQYESDTYILGKDIIQQGLLTGALYRREDGSVWCDLRDEGIDEKLLLRSDGTSVYMTQDLGTAVQRFKDNDIQKLIYTVGNEQDYHFNVLFKILKKLGYSWAENLYHLSYGMVELPEGKMKSREGTVVDADDLMQEMYETAKEKAEDLGKLENLTIEEKEKSYETVGIGALKYFMLKVDPRKKMLFNPKDSVEFNGNTGPFIQYTYARIQSLLAKADYQDRKVTEYEMSDSEKDLIMNIAAFKDVISKAADTLSPALLANYIYDLVKSYNSFYQNNPILIQEDQNMRQFRLELSDLTAKIIKKGLKMLGIETVDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X046</accession>
    <name>C6X046_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781878.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00258"/>
    <dbReference type="EnsemblBacteria" id="ACU06731">
        <property type="protein sequence ID" value="ACU06731"/>
        <property type="gene ID" value="FIC_00258"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00258"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015077_0_0_10"/>
    <dbReference type="OMA" id="QGMEYPM"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="377"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="790" mass="90918" checksum="1CB059A49A969FC9" modified="2009-09-22" version="1">MKFKSIVVALMISVGITAQNHQNNSISNHGNKFEQLGTILPTPNVYRTASGAPGHNYWQNRADYEITAYLDEEKRNLRGSETITYYNNSPDDLDYLWLQLDENQQSSVKNAGYDDRSLIPKQTTVDRLSTTNLPKDDNGYGVNLEKVTDAAGKPLKYVVNKTMMRIDLPKVLKKGEKYIFKIDWNYNIPNRLSMGGRGGYEHFPEDGNDLYTITQWFPRMCVYSDFKGWQNNQFTGRGEFALAFGDYKVTMNVPADHIVASTGVGKNFDQVLSPAQLSRWKQAQTATEPIEIVTLDEAKKAEKSKSKQRKTWIFEAENVRDFAWTSSRKFVWDGMKVTIPENNNQVMAMSLYPKEAYNLYRKFSTRAVAHTIKTYSEFTVPYPYPVAQSIEAANGMEYPMICFNYGRTEKDGTYSEGIKNGMIGVIIHEVGHNFFPMIINSDERQWSWMDEGLNTFIEYLTEEKWDNKFPSRRGPAHAIVDYMKLPKEQLEPIMTNSENIIHFGPNAYAKPATGLNILRETVMGRELFDEAFKTYSKRWAFKHPEPADFFRTMNDASGENLDWFWRGWFYGIDPVDISIDKVTVATPDLDVAPKTREIKYTVEEPLLNDFEDITKVRNREDKNITFYTDKDKETQDFYWRYARGKEKVDTQKEQTMKVDNLVKIPAGEKAKLQNITAYQIDFSNKGGMVMPIILEFTFEDGTKLHDKSSAQIWRKDENKVSKTYYFDKKLKSIQLDPMRETADIDTSNNFWGEIAEPSSKFEVFKQKNGDNARGAAPGNINPMQAAGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X069</accession>
    <name>C6X069_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gly-zipper_YMGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781901.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00287"/>
    <dbReference type="EnsemblBacteria" id="ACU06754">
        <property type="protein sequence ID" value="ACU06754"/>
        <property type="gene ID" value="FIC_00287"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00287"/>
    <dbReference type="eggNOG" id="ENOG50316ZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1494108_0_0_10"/>
    <dbReference type="OMA" id="FQARQLE"/>
    <dbReference type="OrthoDB" id="1797068at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027367">
        <property type="entry name" value="Gly-zipper_YMGG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13441">
        <property type="entry name" value="Gly-zipper_YMGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gly-zipper_YMGG" evidence="3">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="180" mass="18911" checksum="9E3AE71F8A4883BD" modified="2009-09-22" version="1">MKNIVTAGFMSILLMAACTKDNTVAEKSLDQQKMEFQARQLEIEKQKLAIEKEKMAYETQKKADSIEEERKAKQARAAASPQVIRETKTVYVNNTPQSSSNSGSNTGYAGTSQGTTQKQGMSQAAKGTIIGAVGGAAAGALINKKNRGAGAVVGGVIGGATGYTIGRAGDRKSGRVQPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X077</accession>
    <name>C6X077_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781909.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00295"/>
    <dbReference type="EnsemblBacteria" id="ACU06762">
        <property type="protein sequence ID" value="ACU06762"/>
        <property type="gene ID" value="FIC_00295"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00295"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_3_10"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="211" mass="24000" checksum="2C1D0CCACFA8B8DE" modified="2009-09-22" version="1">MLHIKQFAFNPFSENTYVVYNESNNAYLIDPGNFSDAETQTLAKFIADENLNIKNTLLTHAHIDHVLGLQWAYDTFNVPVILHEFEQEILDRNPLSAKQFGFFFKPFEGKTEYINENNRLLLDEDELKILFVPGHSPGSIAYYSEAQKLVISGDVLFEGSIGRSDLYKGNAGQLLESVRTQLFVLADETKVYSGHGNPTTIGFERNHNPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X099</accession>
    <name>C6X099_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781931.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00317"/>
    <dbReference type="EnsemblBacteria" id="ACU06784">
        <property type="protein sequence ID" value="ACU06784"/>
        <property type="gene ID" value="FIC_00317"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00317"/>
    <dbReference type="eggNOG" id="ENOG502ZB0Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155078_0_0_10"/>
    <dbReference type="OMA" id="IHINLYH"/>
    <dbReference type="OrthoDB" id="948988at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024213">
        <property type="entry name" value="DUF3822"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12864">
        <property type="entry name" value="DUF3822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="240" mass="27765" checksum="39BFF5798575AA07" modified="2009-09-22" version="1">MQKLSLLFTKDGLQYQILKNKTVTEEHAFFADENDATTFIAEHLQRILQKSTYTQISVISALNHFTLMPEGFSEHSLGYDLIALNAPISREEEELMLSVDKKYGVQFYYALPNAFYHAIKALDTPVNFNFSGAKFLSSIQAKNQKEIHINLYHNQCEFIALDRKKVILYNNLDMNSEVDFLYFIMFTLSKIEFGIAETTFMVYGETTQNETFISELRKFVKNLKIVFDNVPRKNFILAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A8</accession>
    <name>C6X0A8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781940.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06793">
        <property type="protein sequence ID" value="ACU06793"/>
        <property type="gene ID" value="FIC_00326"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00326"/>
    <dbReference type="HOGENOM" id="CLU_2522656_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970506" evidence="2">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="84" mass="9125" checksum="4CE5F07AC90CA343" modified="2009-09-22" version="1">MKKLITIIGVLAFTGIAQAQSESWFYNSEGEYKAQVEARDPGDAPGGDDPLPAPIDDYIPMLLIAGLGMAAFYARKRTSTPHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B8</accession>
    <name>C6X0B8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781950.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00336"/>
    <dbReference type="EnsemblBacteria" id="ACU06803">
        <property type="protein sequence ID" value="ACU06803"/>
        <property type="gene ID" value="FIC_00336"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00336"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_1_0_10"/>
    <dbReference type="OMA" id="INPRRYF"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="360" mass="40829" checksum="D79C40DAB6A9B2BF" modified="2009-09-22" version="1">MIPVTKPFLPPQQIYQSYLEGIWKRQWLTNMGPLSSDLEMKLKDHLKVNHLLFVTNGTVALQLAIKALELKGEIITTPFSFVATTSSIVWEGCTPIFVDIDEQSLNIDPEKIEAAITENTSAILATHVYGNPCDVERIEEIAVKHNLKVIYDAAHAFGVEINGKSIFEYGDVSTCSLHATKLYHSVEGGLIVTKDSSLLRKLALMRNFGFSGPESFSELGINGKNSEFHAAMGLVNLNYMELIHNKRKELCERYDFRLRNLKAIRPHWHGSSRNNYAYYPVIFESGELLLKCVEFLKINEIFTRRYFYPSLAQSLPYVSPQELPITAAISDKVLCLPLFVDLTLEEVDLISRLILRMQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C1</accession>
    <name>C6X0C1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, GT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781953.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00339"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06806">
        <property type="protein sequence ID" value="ACU06806"/>
        <property type="gene ID" value="FIC_00339"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00339"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_0_10"/>
    <dbReference type="OMA" id="NAMREYD"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="327" mass="38287" checksum="93BF7A68C5B73681" modified="2009-09-22" version="1">MLLSITLATYNVELYLRESLDSIVNQTLPEFELICLDDASSDGTVEILQEYAQRDSRIRLILKKKNEGLAVARNTCLTEAKGKYITFLDGDDFYDPTLFQKAVALAEKDAADLVMWDYVTFWNKADVEALRIKRSDLNAVDPTDKKALLKRPSFIWIKLVRVEKWRQLNIHFPPGYTRQDIPVHWHLITALDKVSLLPERLSFYRQQADATTAKKDGKLFHLVHIMDIVEKYLRENSLYNTYRETFLEQRLNFFAGMYDNIKPELKGEALQLIQDRMSPEIWKFLKSKNNLRLHTRYFFAALLGSFVARAQLALWHLSRTIYRKLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J0</accession>
    <name>C6X0J0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">3-deoxy-D-manno-octulosonic acid transferase</fullName>
            <shortName evidence="8">Kdo transferase</shortName>
            <ecNumber evidence="3 8">2.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00409</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2-&gt;6)-lipid IVA + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28066"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58603"/>
            <dbReference type="ChEBI" id="CHEBI:60364"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.4.99.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.12" evidence="3 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782023.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00409"/>
    <dbReference type="CAZy" id="GT30">
        <property type="family name" value="Glycosyltransferase Family 30"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06876">
        <property type="protein sequence ID" value="ACU06876"/>
        <property type="gene ID" value="FIC_00409"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00409"/>
    <dbReference type="eggNOG" id="COG1519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036146_2_1_10"/>
    <dbReference type="OMA" id="FIKYEFW"/>
    <dbReference type="OrthoDB" id="1163086at2"/>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043842">
        <property type="term" value="F:Kdo transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007507">
        <property type="entry name" value="Glycos_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038107">
        <property type="entry name" value="Glycos_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039901">
        <property type="entry name" value="Kdotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42755">
        <property type="entry name" value="PTHR42755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04413">
        <property type="entry name" value="Glycos_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_N" evidence="9">
        <location>
            <begin position="47"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="416" mass="46946" checksum="7BE252C410921E7B" modified="2009-09-22" version="1">MKTIYNIFVSLLISAMRVGALFNYKLKKGLAGRRQSCDVVKSVFAPDDRVIWMHAASLGEYEQGLPVLEKLKEKFPDYKILITFFSPSGYDNVIHKKHIADAVCYLPFDTERWISDFTGNFKTEIFITVKYEFWYNLMASLKLQGAKIYVISALFYETQIFFKAYGSWFAGQLNKNVDWFFHQTLHSTALAKGIGLKNSSTAGDTRFDRVKKLQQRDNHVDFIDEFKQNSKTLVFGSSWESEERLAEIIVSKNRDVKIIIAPHDLKRVPNLRQIFPASILYSQLKSAEIVQHSNAQVLIIDCIGLLSKLYSYADIAIVGGGFHTKGLHNILEAAVFGIPVFFGNLYQKNPEADGLIAAQGAKCFEDEFFAAPYLLGLLVNDELRLQMGRNAAQYISSQPDATKTIVNKIISGIPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M3</accession>
    <name>C6X0M3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxybutyrate coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00447"/>
    <dbReference type="EnsemblBacteria" id="ACU06909">
        <property type="protein sequence ID" value="ACU06909"/>
        <property type="gene ID" value="FIC_00447"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00447"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030703_1_1_10"/>
    <dbReference type="OMA" id="FFMGANV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="276"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="435" mass="48013" checksum="3849193BB71B0B1E" modified="2009-09-22" version="1">MGINQQKNSNMVQYVSAEEAVSLIKSGDRIFSHGSACTPNCFIDELARQASRLREVEFVSITQQGNVEIAKPQYKDSFYINSLFVSTPVRSAINSEQGDFVPVFLSEIPLLFKKGILPIDVAMVTVSPPDQHGYCTLGTSVDVARSAVDTAKIIIAQVNPRMPRTHGDGMIHYSKIHKMVWHEEELLTVDYGAKVGAEELLIGNNVAHLIDDRATLQMGIGTIPDAVLKCLHNHKDLGIHTEMISDGIVDLVANDIITNKYKGTHSNRTITSFAFGTRKLYDYIDDNPSFAFMDVEHVNYPINIMKNKNMVAINSAIEIDLTGQVCADSIGTFQFSGIGGQMDFMRGAALSEGGKPIIAISSRTKKGVPRIVPFLKQGAGVVTTRGHIHYVVTEFGTAYLYGKSLRQRAKALIEISHPDDREMLEKATFDRFKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N6</accession>
    <name>C6X0N6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribokinase</fullName>
            <ecNumber evidence="4">2.7.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.15" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782069.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00460"/>
    <dbReference type="EnsemblBacteria" id="ACU06922">
        <property type="protein sequence ID" value="ACU06922"/>
        <property type="gene ID" value="FIC_00460"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00460"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_2_1_10"/>
    <dbReference type="OMA" id="DMNTRDT"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="306" mass="33442" checksum="9457AC7BD6CAF6C7" modified="2009-09-22" version="1">MKLLVVGSVAFDAIETPFGKTDKILGGAATYIGIASSILNVESGIVSVVGSDFLQSDLDMLTGRGVNIEGIEVVPDGKTFFWSGKYHNDLNSRDTLITEVNVLENFEPKIPDSMQDSEILVLGNLHPGVQLSVLEKMNQRPKLVILDTMNFWMDSALDTLMLMIAKTDVITINDEEARQLSGEYSLVKAAKTIHAMGPEFVIIKKGEHGALLFHDGKVFAIPALLLEEVFDPTGAGDTFAGGFAAYLAKKEDFSFETMKSAIIVGSAMASFTVEKFGTERLQEVTETEMNARIQEFKDLTSFEVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0R2</accession>
    <name>C6X0R2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782095.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00489"/>
    <dbReference type="EnsemblBacteria" id="ACU06948">
        <property type="protein sequence ID" value="ACU06948"/>
        <property type="gene ID" value="FIC_00489"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00489"/>
    <dbReference type="eggNOG" id="ENOG502Z8HM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082721_0_0_10"/>
    <dbReference type="OMA" id="FKILHWE"/>
    <dbReference type="OrthoDB" id="1802310at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019852">
        <property type="entry name" value="Motility-assoc_prot_GldL"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03513">
        <property type="entry name" value="GldL_gliding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="228" mass="25444" checksum="4B48754BA02833CC" modified="2009-09-22" version="1">MFKSKEAIYNFIYSFGAAIVIIGALFKLTHWSIGPLTGNVTLAIGLITEAIIFIIFAFDAPKSEESYAWENVYPELLDRDANPNPKHSTVGFQAAEVKELEVSLSEKLDKMLEDAKLDVTLFERLRTGIDKFSNSVDQINQTVDVTGSTQKYNDQLVLAASHLESMNALYALQLEHGQSQAEYSKKYVEDMQKSAAHSERFNEELSGLTTNLNNLNRVYGGMLSAMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0R4</accession>
    <name>C6X0R4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GldN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00491"/>
    <dbReference type="EnsemblBacteria" id="ACU06950">
        <property type="protein sequence ID" value="ACU06950"/>
        <property type="gene ID" value="FIC_00491"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00491"/>
    <dbReference type="eggNOG" id="ENOG502Z7JF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068220_1_0_10"/>
    <dbReference type="OMA" id="VNFPLYY"/>
    <dbReference type="OrthoDB" id="1695370at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019847">
        <property type="entry name" value="Gliding_motility_assoc_GldN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19841">
        <property type="entry name" value="GldN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03523">
        <property type="entry name" value="GldN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973449" evidence="2">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="356" mass="40268" checksum="806AFC233C1078C0" modified="2009-09-22" version="1">MKKVIFLFLSLGFLSVQAQTKRNSANTTPQTNQTAEPEAPVVDTSGAAMDPAEGGVAADEPVNSMSILNAKSPESFRQFRETGMIKQGDSMVSVKKEPLKYGFIEDKDILKSMVVWEIIDMNDKINQPFYHNEDGLVSQNKSLYQLLFDAINDGRITEVYDDEMFQTRLSPDAISARIKNEVMSDAGIDRINEAGTLTEDEKREYTNVYETKTENVKVLKIKGMWYIDRRDSQMKYRLLGIAAMGQDPSTMGQYGPDGQPIASKDELIDLFWVYYPDARNVLANSVVFNSKNLSSDITFDDILNARRFSTIIYKSDNGLGNGVIKDYIPRDADAQLEESERIKAQILEMENDMWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S2</accession>
    <name>C6X0S2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01588"/>
    <dbReference type="EnsemblBacteria" id="ACU08035">
        <property type="protein sequence ID" value="ACU08035"/>
        <property type="gene ID" value="FIC_01588"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01588"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261344_0_0_10"/>
    <dbReference type="OMA" id="CGNIYLA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1336" mass="146306" checksum="C5320B7986A52F3C" modified="2009-09-22" version="1">MRKTGYCSCERNDIYLGTIYLMKKNLLLAFFFSFSASLFSQKLQTRSDALFYENKGQIIDQNGNANPDVKYLLNVGGLNVHIKKQGFSYDVYESKRTLKKGLEKSDRNNFQGTKKRPEYDVEQQFHRVDIDFVGANKNPQITAEGKSTDYDNYYNLPHLPAGAEKVHRFERITYKDLYANIDLVFIKPADSLKPVEYNFVVSPGGKISDIKLQFKGAKTNLKDGKISMALRFGEMQENIPASWTEAKGKKQELTVAYSDLGNDTYGFKTTQDTFDKTVIIDPVPTRIWGSYFGGSGDEFGWIKPDRFDNIFLHGYTSSANNVATSGSHQLTLAGGYDAFVNKITKDGQKVWGTYYGGQYWDASGGLDFDNHDNIFVVADIHIPNPAHPGNVYYYFGQLAILKFKPDGTLVYEKIFGGKRDEISYDLRYYNDNIYILGETFSDDLATPGAFQDSSVSGMQAGFVGKFKASDGSTEWISYITGNSYTTVGKIFNANTHGIEIIATTRATDFPMVNAFQPTSHVAPGSSYNNGLYLNFSETGALLRSSYVGENHSYYFESARRFGDEIFFGAHVYTKNQASFFIANLLNNTVVEKNIPVAYGLQTSTYIDVHRNLFIANYACPGDAGLNQVATPGAFMEISGPGCTSHFMKFDENLNKIWGTFYPGHTQIPFITKDNSNNIYFWGLNFGTTPGMVTPGTFQQTASSTNDEMFIAKFADCKSTVNISFSPTCIGQNLQLNASGGSTYEWFGPNNFHSTLQNPSINNAQAINSGEYFVRITGGQSCGGIFSLKVNIGSPTGPVLDLPALPHLTGVCSVTVTTLPTATTGCGTKITGVTSDPITYTIPGSFVIHWKFDDGEGNILTQNQNVTITGIAKPVASPTQSFCKIASPTIVNIAITGTEIKWYDAAGNALNTNTLLTDGTKYFATQTLSGCESAKFEITVTLNDPAPPTGNIQQDFCSAQNPDLSNLVVSGTDVKWYDSLGNSIPISTPLIDGETYYATQTVSGCESTTKLAVKVSVANGGIPAKDHAESICNDTVSTSKTVDLNDYKSDLIANTTDLTFEFYNASNQLILNPSNVTLTIGSNEFIVKISNTLGCFVSVKLNLTFNPKPALNLPTNAEFCNGQSVTLDAGAGFSSYEWTKDSDLNVISTSQTLTASEIGKYTVTVTNAFNCKNSASVTVTKSPLASITGVQIVNNTATVQMSETGDFLYSLDNRIWQISNVFSNLSNGNHTVYVKTSGGCVIGQMDFTIFNVSNSFSPNGDGKNDTWKVGGLENYPNSEITVLDRWGNAVLNKVSTGSFEWDGKLNSRPLPTGNYWYQIKVSDGRILNGWLLIKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X188</accession>
    <name>C6X188_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismate synthase</fullName>
            <ecNumber evidence="2">5.4.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.4.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806486.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01758"/>
    <dbReference type="EnsemblBacteria" id="ACU08201">
        <property type="protein sequence ID" value="ACU08201"/>
        <property type="gene ID" value="FIC_01758"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01758"/>
    <dbReference type="eggNOG" id="COG1169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_8_0_10"/>
    <dbReference type="OMA" id="TMWHLSS"/>
    <dbReference type="OrthoDB" id="1469584at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="72"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="323" mass="36632" checksum="DDF9AEE63255936E" modified="2009-09-22" version="1">MLFFSFPFSDIIYATDDSPGRNGVSFLSFDQSEIIGFEGDCKEISIDEFLNKPILTADFSTILPHFEQETESSYTQKLTNVIAFIRENRLKKLVISRRKSVDFNDAQVNLSQTFLNLKTAYPNAFVYVFLKDGKCWIGAFSELLGKFNKNTAEFETMALAGTIPVNEEWTRKEIEEQKPVAEYILNILKQYSSTVRVSSTADHLSGNIKHLRTDFKAEIKAEDLENIIAELHPTPAVCGIPKEICTKAIAAFEDHPRKFYAGYIKVETDESVQYFVNLRCAEFFQNAALVYVGGGITAESSPQKEWRETELKSEAIIKNLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B3</accession>
    <name>C6X1B3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate regulon transcriptional regulatory protein phoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01783"/>
    <dbReference type="EnsemblBacteria" id="ACU08226">
        <property type="protein sequence ID" value="ACU08226"/>
        <property type="gene ID" value="FIC_01783"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01783"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_10"/>
    <dbReference type="OMA" id="IDRVWGS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="227" mass="25760" checksum="F5135DEED5F5BFF2" modified="2009-09-22" version="1">MKMTQKKILLIDDEQDILEILSYNLQKEGYEVHTAQNGNEGIQKAKEIVPDLILLDVMMPEKDGIETCQDLRKLPDLQKTLIVFLSARSEEFSQLAGFQAGANDYIVKIIKPKVLISKVNALLQLTSNVYDSKKTITAGDLVIDKDNFRVSKSGQQFLLPKKEFDLLYLLASNTNKVFKREEILEKVWGNDVIVGERTIDVHIRRLREKLGIGTIQTLKGIGYKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B7</accession>
    <name>C6X1B7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Ribonuclease</fullName>
            <ecNumber evidence="8">3.1.27.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_01787</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.27.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01787"/>
    <dbReference type="EnsemblBacteria" id="ACU08230">
        <property type="protein sequence ID" value="ACU08230"/>
        <property type="gene ID" value="FIC_01787"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01787"/>
    <dbReference type="eggNOG" id="COG4290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104572_1_0_10"/>
    <dbReference type="OMA" id="PDYYITK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001887">
        <property type="entry name" value="Barnase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001013">
        <property type="entry name" value="Barnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00117">
        <property type="entry name" value="BARNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001013-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="19363" checksum="333ABC9801BE9719" modified="2009-09-22" version="1">MKMNKQSLKLVLFFIIGMLAAFLVMYFITDYQTEKVSSATVNQTESQAQSTSQAENTNTLPASSEIDELTAERTVIDYVKQNKALPDYYLTKAEARNQGWVASKGNLCDVLPGKAIGGDKFSNREKTLPSGNQYFEADVNYSCGRRNADRIVYTKNGEVWLTKDHYKTFGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G3</accession>
    <name>C6X1G3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC superfamily ATP binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806561.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01833"/>
    <dbReference type="EnsemblBacteria" id="ACU08276">
        <property type="protein sequence ID" value="ACU08276"/>
        <property type="gene ID" value="FIC_01833"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01833"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_10"/>
    <dbReference type="OMA" id="RYFMDKI"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="317"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="574"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="349"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="630" mass="72785" checksum="0BD6D577ACAA2C8F" modified="2009-09-22" version="1">MNYVSAENLTKSYGLKVLFKDIAFNVNEGDKIAIVAKNGSGKSTLLKILMGTEIADSGNVVISKDIQVVLFDQEIEFDSGLSIEEFMMTLDSAPIMAVKSYHHALHTEDPDDLDKALAQMELHKAWDLENEMKQILTQLKITDLEAKMGTLSGGQIKRVALAKLLTETRAEHRHILLIMDEPTNHLDVEMVEWLENYLSKAKITLLLVTHDRYFLDAVCDMIWEMEDNNLYVHNGSYATYLENKIIREDNLNSTIDKAQNLYRKELEWMRRQPKARTTKSKSRIGDFYETEKVAKQDTRKDKLELDFEMKRLGKKILELRHIDKSFGSKVLLKDFSYQFQRGEKIGIVGDNGTGKSTLLNIIQGLEPYDNGEIETGETIKFGYFSQKGLKYKEDERVIDFIREIGENFPLANGRTISASQFLRLFLFDDQTQYSPISKLSGGEKRRLHLMYVLYRNPNFLIFDEPTNDLDLPTLTVLENFLLQFQGSLIIVSHDRYFMDRIVDHVLAFEGQGKIKDFVGNFSEYREARSQEQSKKNQVAVKQEVAKPAEVVIKQDAPKPVQSQRKLSFKEQRELEMIDKEMPKLEKNRAEILEKLNNETDYDKISVLSTELEKIGNELENLELRWLELQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I5</accession>
    <name>C6X1I5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BatC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01855"/>
    <dbReference type="EnsemblBacteria" id="ACU08298">
        <property type="protein sequence ID" value="ACU08298"/>
        <property type="gene ID" value="FIC_01855"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01855"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072309_0_0_10"/>
    <dbReference type="OMA" id="KHKAFHN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="246" mass="28012" checksum="0E73A5106C903B2E" modified="2009-09-22" version="1">MNWNSIFTVILLVFASADFSAQKNYNTLVYEGNKEFDKNNFENSSSKYLSAIKLQDKDFTAHYNLGNALYKSKKYEEAKAEYQKADQLATNLSDKAAALYNLGNTYMQTENSKKAAEHYRQALKQDPYNETIRKNYEIAMLKEKEKEEEKNQKNKGGGGGDAQNKDQNQGQDKGNTPQNQNGSGQKNKGEGEGDDPNKNKNDNSGKMPKDLENSILNRVENKERETAKRILNKNSYSMPQSNEKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J1</accession>
    <name>C6X1J1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-beta hydroxysteroid dehydrogenase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806589.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01861"/>
    <dbReference type="EnsemblBacteria" id="ACU08304">
        <property type="protein sequence ID" value="ACU08304"/>
        <property type="gene ID" value="FIC_01861"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01861"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_10"/>
    <dbReference type="OMA" id="SVRMMRA"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="334" mass="37950" checksum="50EE921090282C05" modified="2009-09-22" version="1">MVLVTGATGILGRVIVLELLKRGQTVRATKRKSSNILEVKDSYRFYTENASEYFDKIEWIHVDFNDLFSLETALQDITEVYHCAATVSFNPEMQNTMFRTNIDGTKNLLIACEGSSVKKFCFISSTAVLDGLNDQGELDEDSDYNLKTDHSAYAISKHLSEMEVWRASAEGLNTVIVNPGIIIGSGNWHESSGQIFKNFSRGFTFSGGTSYIDVRDVAKVSIELMEKHVFGERFVLASENRRFVELATMVRKKLGKPAPRIIPKGLITFGRILNFFLGWLLRPLKMINRVNTETINSFQKISNRKITEKLDFKFIPIEESIDFHLTNYLSELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M2</accession>
    <name>C6X1M2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase</fullName>
            <ecNumber evidence="5">5.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5-keto-4-deoxyuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">DKI isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kduI</name>
        <name evidence="6" type="ordered locus">FIC_01892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate</text>
            <dbReference type="Rhea" id="RHEA:23896"/>
            <dbReference type="ChEBI" id="CHEBI:17117"/>
            <dbReference type="ChEBI" id="CHEBI:29071"/>
            <dbReference type="EC" id="5.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the KduI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806620.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01892"/>
    <dbReference type="EnsemblBacteria" id="ACU08335">
        <property type="protein sequence ID" value="ACU08335"/>
        <property type="gene ID" value="FIC_01892"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01892"/>
    <dbReference type="eggNOG" id="COG3717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062609_0_0_10"/>
    <dbReference type="OMA" id="VYSMYDR"/>
    <dbReference type="OrthoDB" id="1047507at2"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008697">
        <property type="term" value="F:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00687">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007045">
        <property type="entry name" value="KduI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027449">
        <property type="entry name" value="KduI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38461">
        <property type="entry name" value="PTHR38461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006625">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="280" mass="31788" checksum="6DA0A51CE66E30B0" modified="2009-09-22" version="1">MKTNFSFRYAANPADVKSYDTEKLRSEFLIQNLFTENSVNLVYSMYDRLIVGGAMPLNEKLTLETIPYLKSENFLDRREIGIINVGGKGEIHVDGEIFELDKKEALYIGKGVAEVLFVSKDSVNPALFYINSAPAHEKFPTKKVGKENAEVIQLGDEKQANRRVLNKLIVNSIVQTNQLQMGLTELLPGNIWNTMPAHTHSRRMEAYFYFDLEQGQTISHFMGEPQQTRHIFMQNYDAVLSPEWSIHSGAGTSNYSFIWGMAGENLDYGDMDICAPNELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1N0</accession>
    <name>C6X1N0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806628.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01901"/>
    <dbReference type="EnsemblBacteria" id="ACU08343">
        <property type="protein sequence ID" value="ACU08343"/>
        <property type="gene ID" value="FIC_01901"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01901"/>
    <dbReference type="eggNOG" id="ENOG503262N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117190_0_0_10"/>
    <dbReference type="OMA" id="WLPYRGG"/>
    <dbReference type="OrthoDB" id="1226328at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021958">
        <property type="entry name" value="DUF3575"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12099">
        <property type="entry name" value="DUF3575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="SSF103515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973347" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="23999" checksum="10A831E297B41E79" modified="2009-09-22" version="1">MKKILFALAIAVGSMANAQLQDSTHQKQLYVKANTLFLPVGVLNAGLEYQVSKKMTVQADVFISPWKSFMGKYAQMYMLGFDGRYYFNEAFKHFYVGANISAARYKMQKYNYWSDGPYQYQENSPIYVTSDLYQDGYALFLGATVGYQWQLSENWNLDLYVGAGTAQSMYRGYHKTLGVRYDTDPNRDYNLSGELVPYRGGLMISYKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V4</accession>
    <name>C6X1V4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806702.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01975"/>
    <dbReference type="EnsemblBacteria" id="ACU08417">
        <property type="protein sequence ID" value="ACU08417"/>
        <property type="gene ID" value="FIC_01975"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01975"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_7_0_10"/>
    <dbReference type="OMA" id="DPIPIQP"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="36"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="534"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="670" mass="74785" checksum="07974743AC87DFDD" modified="2009-09-22" version="1">MSKLDAKIPSGPLAEKWENHKNHMNLVAPNNRDKIDIIVVGTGLAGGSAAATLAEQGYNVKAFCYQDSPRRAHSIAAQGGINAAKNYQGDGDSTYRLFYDTIKGGDYRAREANVYRLAEVSANIIDQCVAQGVPFGRDYGGQLDNRSFGGVQVKRTFYAKGQTGQQLLLGAYSAMSRQIGKGRIKMYNRHEMLELVIVDGKARGIIARNLITGEIERHSAHAVVIASGGYGNVYFLSTNAMGSNVSAAWKIHKKGAYFANPCFVQIHPTCIPVHGTAQSKLTLMSESLRNSGRIWVPKNVEDAVAIREGKLKPENIAEENRDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGIENNDTMEGVYLDFSTEIMKKGKESAIEKNIHDPSPQLIYDLGKAWIEEKYGNLFVMYEKITADNPYVTPMKIYPAVHYTMGGVWVDYNLQSTIPGCFVLGEANFSDHGANRLGASALMQGLADGYFVLPYTIADYLSSDIRTGTIPTDSPAFDAAEKDVRDQINHLINNKGKHSVDYFHKKLGLVMWNKVGMGRTPEGLKEAIKEIEEIREEFWRDVKVPGTNEEMNMELEKAIRVADFLELGQLMAIDALKREESCGGHFRWDHSTPEGEAERDDENFKYVAAWEYQGSDINQETLHKEDLVYENIEVKTRSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X215</accession>
    <name>C6X215_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA recombination protein RmuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806762.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02036"/>
    <dbReference type="EnsemblBacteria" id="ACU08478">
        <property type="protein sequence ID" value="ACU08478"/>
        <property type="gene ID" value="FIC_02036"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02036"/>
    <dbReference type="eggNOG" id="COG1322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024057_0_0_10"/>
    <dbReference type="OMA" id="GDSKMQG"/>
    <dbReference type="OrthoDB" id="1309809at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="63"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="501" mass="57328" checksum="F94106856FF03034" modified="2009-09-22" version="1">METTSLIIGLFAGAIVGAVILYFVLKSAHVPRKLYDDLNGNFIRNHSELQNSTLKISDLDNFLKTEKQINQQQTELLNTLKNEMATLSAEHATLQNQFREQRELNAKQSLQIDGIRSEKEEIFGRNAELAAINESLQQSLKNQKEEIEKIQETAKNEFKNLANEILEEKSKKFTDANKENLDILLKPLGENLETFKKRVNEVYDNEARERFSLNNTIKLMMEQTTKVSQEANNLATALKGQTKTQGNWGEMILERILEDSGLCKDREYFSQYNIKTETGENQRPDFVLKLPGNQIVIIDSKVSLNAYERMCSAETEDERKQNLSLHIAAIKKHIDTLALKRYDNLKEALDFTIMFIPVEPAFLTAVQYDQQLWNYAYHKHIILLSPTNLIAYLKLISDVWKRADQNQNAEEIARQAAALYDKFEGFVSDLLNVGKKMEGAKQDYESAMKKLSTGNGNLVKATEKLRQLGVKPKKQLPNQLLERANVEEIDFANDESVTEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X239</accession>
    <name>C6X239_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806786.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02060"/>
    <dbReference type="EnsemblBacteria" id="ACU08502">
        <property type="protein sequence ID" value="ACU08502"/>
        <property type="gene ID" value="FIC_02060"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02060"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_5_2_10"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="80"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="323"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="457"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="570" mass="64322" checksum="BAF308723BA559BC" modified="2009-09-22" version="1">MSQKWIYRPEPDEETVDAISSSLGFGTFESKILVMRGIDNYQKAREFFKPNLNDIHNPFLMKDMQIAVDRVATAIENGEKIMVYGDYDVDGTTAVALMYLYLSKIVDKKYLEYYIPDRNIEGYGISIEGIDHAKNNGFSLIIALDCGIKAIDKVDYAKSLAIDFIICDHHLPGDEIPDAVAVLDPKRKDCRYPFKELSGCGVGFKLCQGLNSIYKIPEAELFELTDLLAISIAADIVSMTGENRVLAKQGLKVLRKSRNLGLRMLIPEEKLATFEISNIVFEIAPKINAAGRISQGKAAVELMVSDNLKQAHQIVNDIITLNDSRREMDMSSTTEALLQVEETQQVQNYTTVVYGSGWNKGVIGIVASRLTETYFKPTLVFTDGNNGEMVASARSVADFDVHDALENCSEFFLKFGGHPAAAGLSMEKDKFDKFREKFEKVVSEKIQQHQKEPSLLIDSDVIPDDLNKDFFSFHRKLAPFGPHNMKPILAMKNQKISGYVKTMGKDNCHLKFYIKQESTGRNIECVGFKLGKFVEDFRNRPFDIAFTAEENHWKGNVTYYLNIRDVKFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X257</accession>
    <name>C6X257_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ordered locus">FIC_02083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806804.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02083"/>
    <dbReference type="EnsemblBacteria" id="ACU08520">
        <property type="protein sequence ID" value="ACU08520"/>
        <property type="gene ID" value="FIC_02083"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02083"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_10"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="OrthoDB" id="493793at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="427" mass="46937" checksum="0B6EEB2115ADEBD4" modified="2009-09-22" version="1">MLYQRSSALFEEAYKYIPGGVNSPVRAFKSVGGVPIFMKSAKGAYMTDADDNKYIDYINSWGPAILGHTHPEVLEAIKKQAESGFSYGTPSELETEIAKLIAENVPNIDQIRMVSSGTEACMSAIRLARGFTGRDKFIKFEGCYHGHSDSFLIKAGSGAATFGNPNSPGVTAGTAKDTLLARYNDIEQVEDLFRHNSGEIAAVIVEPVAGNMGCVLPENNFLQNLRKLCDENGALLIFDEVMTGFRLGFGGAQEVFNVKADLVTYGKVIGGGLPVGAFAGRNEIMDHLAPKGAVYQAGTLSGNPLAMRAGLTTLELIRKDKNFYQNVNKTTETLDFEIGKILNSKNIEHRINRKGSMMSIFFHINSVSNFDEAAQANHALFNNFFHFLLKNGVYLPPSGYETWFISDAIKEKEIDRTLEVIRQFEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X262</accession>
    <name>C6X262_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806809.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02088"/>
    <dbReference type="EnsemblBacteria" id="ACU08525">
        <property type="protein sequence ID" value="ACU08525"/>
        <property type="gene ID" value="FIC_02088"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02088"/>
    <dbReference type="eggNOG" id="ENOG5032YB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113282_0_1_10"/>
    <dbReference type="OMA" id="KPGIDKA"/>
    <dbReference type="OrthoDB" id="1557777at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4136" evidence="1">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="175" mass="19691" checksum="C1B797BE8B0CBCCD" modified="2009-09-22" version="1">MKKYIFLLLASATLGLTSCSPFQVKSDYAETANFNTYKTYKLRIDDLKLNDIDKDRVLNEVSRQLQKKGLSVSESPDLIVNVKANHKKIQDIQSSRPYGMYGWGGPFGWGVGMNRTWTSNYNQGALILDLIDARTQKLVWQGTGSGISVDSPKSKQKQIPEIVAEIMANYPPQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X274</accession>
    <name>C6X274_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YejK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806821.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02100"/>
    <dbReference type="EnsemblBacteria" id="ACU08537">
        <property type="protein sequence ID" value="ACU08537"/>
        <property type="gene ID" value="FIC_02100"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02100"/>
    <dbReference type="eggNOG" id="COG3081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068639_0_0_10"/>
    <dbReference type="OMA" id="MYYYLVY"/>
    <dbReference type="OrthoDB" id="1553657at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007358">
        <property type="entry name" value="Nucleoid_associated_NdpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04245">
        <property type="entry name" value="NA37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="338" mass="39558" checksum="8929659E5AEFFD1A" modified="2009-09-22" version="1">MLSKIIVHKVGNRINQESLILSQEVLQLDEEMTELLEDFFLKSFKSEEQYRFYSETYLVNNTVYGAAAEIFEDKAKFIEEAENIAQHLYDITENPRVQSGELFIVYFEGEENVDGNKIDSIGIFKTENKNPFLKIFPEGQTFEIEKDYGIGLAKLDKGALIYNSSKESGYAVSVVDNNKNGDADYWFENFLKVKQRDDEYFHTQETLSVYKDFITKQLPQEFEVSKADQADFLNKSINFFKEKDTFDYEEFTNEVLEDKSVIESFSNFKSDYEQEMQVSISEDFAISEAAVKKQSRGFKSVIKLDKNFHIYVHGDRKMIETGQDEKGKYYRLYFEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2I7</accession>
    <name>C6X2I7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF695 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806934.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02215"/>
    <dbReference type="EnsemblBacteria" id="ACU08650">
        <property type="protein sequence ID" value="ACU08650"/>
        <property type="gene ID" value="FIC_02215"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02215"/>
    <dbReference type="eggNOG" id="ENOG502Z8C2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754052_0_0_10"/>
    <dbReference type="OMA" id="FLIWREK"/>
    <dbReference type="OrthoDB" id="743650at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016097">
        <property type="entry name" value="DUF695"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05117">
        <property type="entry name" value="DUF695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF695" evidence="1">
        <location>
            <begin position="229"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="356" mass="41735" checksum="0D9FA328A08653A1" modified="2009-09-22" version="1">MNEKTTQHLDYGAFWDFFQNNEQQFFNILKNYEEVEEKFLDVVLPKLNTINDDFLLLGGMCDEETAELIITVDGNIPSIVYAEELVSAAPILKNWRFTALKPESDIESSTISMGEMQFTKDNIFFYPNDDENYPDEIDLVFIHEDLNEENRNEITNGTFIFIDNYLGELNFLTQIDNFIITGKDEAEKELIPISKLKDFLSWREREFTEKYAGSKIATDEDSYSLFEANLENGLPLIATINTDLLKWDEKASHPWISVFRIEYEGDEHSGFPGEEDYEKFNSIEDEMLQLLKPAEGNLNIGRETAANLREIYFASRDFRKISKVFAETVRRYPEYTITFEIFKDKYWQSFERYGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K8</accession>
    <name>C6X2K8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806955.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02238"/>
    <dbReference type="EnsemblBacteria" id="ACU08671">
        <property type="protein sequence ID" value="ACU08671"/>
        <property type="gene ID" value="FIC_02238"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02238"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_10"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="126" mass="13831" checksum="C8A2312133B869CB" modified="2009-09-22" version="1">MKTIISTSNAPAAIGPYSQANLANGILYISGQIPLNPESGKLVEGIEKETHQVMKNLEAILSEAGMTFKNVVKASIFLKNMDDFAVMNDIYASYLDADHYPARETVQVSCLPKNVDIEISMIAYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M6</accession>
    <name>C6X2M6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806973.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02256"/>
    <dbReference type="EnsemblBacteria" id="ACU08689">
        <property type="protein sequence ID" value="ACU08689"/>
        <property type="gene ID" value="FIC_02256"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02256"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_10"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="367" mass="39655" checksum="077466BAF25B86DC" modified="2009-09-22" version="1">MLTKDKVQAFLKEIEVADLVHNFQVMGNDVYIDMTAHSPAMHEKKKLEAAMKQAFASEFGEEINLKLKIVSPEPSEIQQSQIKGKQIKGIQNIIAVASGKGGVGKSTVASNIAVTLAKMGFKVGILDADIYGPSVPTMFDTVGGKPVSVEIDGKNLMKPIENYGVKMLSIGYFSGANQAVVWRGPMASKALNQMIRDAAWGELDFLLIDLPPGTGDIHLSIIQEVPVTGAVIVSTPQHIALADVRKGIAMFQMESINIPVLGLIENMSYFTPEELPENKYYIFGNQGAQYLAEDLGIPVLGEIPLVQSIREAGDVGRPAALQDGSVIADIYRTVTQNMIESLVERNKNLPATEAVKITTMAGCSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M7</accession>
    <name>C6X2M7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proton/glutamate or proton/aspartate symport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806974.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02257"/>
    <dbReference type="EnsemblBacteria" id="ACU08690">
        <property type="protein sequence ID" value="ACU08690"/>
        <property type="gene ID" value="FIC_02257"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02257"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_0_10"/>
    <dbReference type="OMA" id="YLYIAVI"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="475" mass="52162" checksum="911F7758B65582C3" modified="2009-09-22" version="1">MKSRFLQIFPFFTLTVVVILHAINMLNPLPEDYLAFGHLLFVLGMVTYALMRKNLTTWILISIVIGVIVGRDYPGVALALQPLSQGFIRLVKTIVGPILFATLVYGIAGHSDLKQVGRMAWKSLLYFYCATTIALFIGLAAINISKAGVGIDASKIPHQELPVTSAVKDADMRALESIPESNQWLFKTTAFFRDVFPENIIKSIYENQVLQIVVFAVIFGIGLAKLPEQKKRPLVDFMESLAETMFKYTHIIMYFAPIGVGAAMAYTVGHMGIDILKYLFMLLLTLYCALIAFILLVLLPIALYMKVPIKKFIEAIKEPVSIAFATTSSDAALPVVMQNMEKFGVPRKIVSFVVPTGYSFNLDGTTLYLSLASIFVAQAAGMDLSFGQQLLICLTLMITSKGVAAIPRASLIILIATADQFGLPIFIIAAILGIDELMDMGRTSVNVIGNCLASVVIAKWEGEFDQEKALAFEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P3</accession>
    <name>C6X2P3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ordered locus">FIC_02273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02273"/>
    <dbReference type="EnsemblBacteria" id="ACU08706">
        <property type="protein sequence ID" value="ACU08706"/>
        <property type="gene ID" value="FIC_02273"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02273"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_10"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="25"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="626"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="818"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="544"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU08706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="882" mass="101647" checksum="B2E7E812C5F9C4E0" modified="2009-09-22" version="1">MQQFRLTTDFMQLSDKYNPTETEQKWYSYWLENNYFHSEPNEKPPYTIVIPPPNVTGILHMGHMLNNTIQDVLVRRARMQGFNACWVPGTDHASIATEAKVVAKLKEEGISKADISREEFLKHAWEWTDKYGGTILEQLKKLGCSCDWARTRFTMEPKLSQQVIKSFVDLYNKGLIYRGYRMVNWDPEAKTNISDEEVIFKEQNGKLYFLKYKIEGTEEFLSVATTRPETIFGDTAVCVNPNDERYAHLKGKNVIVPIVNRSVPIIEDEYVDIEFGTGALKITPAHDINDYEIGKKHNLQVIDSLDDDANLNEYGQHYAGKNRFEVRKLIAKELQEKDLLLKAEDYVNKVGTSERTGAVIEPKVSVQWFLKMSEIAKPALDVVMNDEVKFHPEKFKNTYRHWMENIRDWNISRQLLWGQQIPAYFYGEGENDFVVAETIEEALELAKEKSQNSNLEISGLRQDADALDTWFSSWLWPISVFDGMLDPENKDINYYYPTSDLVTGPDIIFFWVARMIMAGLEYRKEVPFKNVYFTGIVRDKQRRKMSKSLGNSPDPIELMEKYGADGVRVGILLSSAAGNDLLFDEELMLQGRNFATKIWNAYRLMQGWEKNEAIKATAADNQAIEWFGHQMDKTIAEIADQFAKFRISDALHLVYKLIWDDFCSWYLEAVKPAFGEPVSAEVYGKSIEYFEELMKLLHPFMPFLSEELWQNIADRTPENALVITQQRKEEAFNNDVINEFEISKEMITGVRNYRQTKGISPRESVEVYTNAATLSNENLIKKLANISEINFAQKTEKPSYTFLVGSTEIAIPLSANLDLAEEKIKTEDEIKYLNGFLISVEKKLSNEKFVANAKPEVVASERKKQKDAQDKITLLEAKLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q8</accession>
    <name>C6X2Q8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807005.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02288"/>
    <dbReference type="EnsemblBacteria" id="ACU08721">
        <property type="protein sequence ID" value="ACU08721"/>
        <property type="gene ID" value="FIC_02288"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02288"/>
    <dbReference type="HOGENOM" id="CLU_583619_0_0_10"/>
    <dbReference type="OrthoDB" id="973947at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973505" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="402"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="468" mass="49969" checksum="8BBED5EAAB9EEEA4" modified="2009-09-22" version="1">MKKILLLVAVTLLPLPLLGQKQAASINLQQTGLYSTPASATLSVHGNMVLDGLKRKIVIADDSVIISENNQSNSTQHAPAACLTAPNGQYPTTTFSPSCNGNTENITTLAFTGEYSVLNVTTGVSYTFSVSNPAYYITISDNTGTAVLASGTASVVWTSTLTGSIRFYSHADSSCGIGPTTVTHTRAVKCGLPPMEPDYGCDQTYTGTPDVASNIIKNSTMNFAVANDFFVPMESAAYYLQYITADVVPLAAAGAADISSFNIQIMSNSAGDTPGTVIHTLANVVPSSITPLPNPFAGYPTFAVKLNLGNYSLPVNANADTRYWISLQANSASNTSIYWIGHQYNEGWKTKSNYISADGGVTWAQVISAAAPGQHYESNMTVDAECSLAAVNERDRNNVTFYPNPVKDFLTLVSQTKIETVHLYNISGQKMTISPNSRLNMRGLVPGVYIISVILADGRNESFKVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q9</accession>
    <name>C6X2Q9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02289"/>
    <dbReference type="EnsemblBacteria" id="ACU08722">
        <property type="protein sequence ID" value="ACU08722"/>
        <property type="gene ID" value="FIC_02289"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02289"/>
    <dbReference type="HOGENOM" id="CLU_3135935_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="49" mass="5904" checksum="B07FFA8766812392" modified="2009-09-22" version="1">MAQFLLVKFINFLRIRAFTLSRNRLSPELNFRKIIPIDKEFYIFAAINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S9</accession>
    <name>C6X2S9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807026.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02309"/>
    <dbReference type="EnsemblBacteria" id="ACU08742">
        <property type="protein sequence ID" value="ACU08742"/>
        <property type="gene ID" value="FIC_02309"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02309"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_10"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="5"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="291" mass="30686" checksum="C0BDAC11A70772EA" modified="2009-09-22" version="1">MKALVFPGQGSQFVGMGKELYDSRKDIKDLMDSANDILGFDIISIMFKGADEDLKKTEVTQPSVFIHSVAALKAVNGQGAAMVAGHSLGEFSALVANGVLSFEDGLRLVSARANAMQAACDANPSSMAAILGLSDDKVEEICATIEGIVVPANYNCPGQLVISGETAAVEEACVKMKEAGAKRALMLPVNGAFHSPLMAPAQEQLAAAIEATRFRNATIPVYQNITTTAVTDPEEIKQNLISQLTGPVKWTQTVQNMIKDGATTFIEVGPGKTLQGLIKKINSEAEVSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V8</accession>
    <name>C6X2V8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807055.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02338"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08771">
        <property type="protein sequence ID" value="ACU08771"/>
        <property type="gene ID" value="FIC_02338"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02338"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_10"/>
    <dbReference type="OMA" id="WIHTDYS"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="384" mass="44112" checksum="F5FBEF4826AD8CD1" modified="2009-09-22" version="1">MKKKKILIRIGSLRHGGAEKVLATFLKKIPTDKYEIDLLLNLYSGKYLSYIPDYVTVLYLNKGEMITTNRPKDLPVKTFRKLYQGFLKRFPKVLYKTVLKGKKYDIEFAAIHGMRDEILNSPLKSSKKIIWIHNDLKKTGFHNYTDSEIRKFFGFDKIMVISAKIQQDLENLATNNDDHSKIVRIYNPLDTEEILGKANEPIGNYKFSNSVKTFVSVGTVFPQKGFDRLLKAHKRLLDEGFEHRILILGDGYDFENLKKLQKELGLSETTTLLGYTDNPYPFVKAADFYLLSSRYEGFPTVLSEAVALKKKIIATDVSGVRELLADGKLGLITDNSEEGIYSGIRTALTNPQDFEMYVENLRRYEMPFNLENSVRSIMKIIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X9</accession>
    <name>C6X2X9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxygen-insensitive NAD(P)H nitroreductase</fullName>
            <ecNumber evidence="3">1.5.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807076.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02359"/>
    <dbReference type="EnsemblBacteria" id="ACU08792">
        <property type="protein sequence ID" value="ACU08792"/>
        <property type="gene ID" value="FIC_02359"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02359"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_1_10"/>
    <dbReference type="OMA" id="PWHFVVA"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="23785" checksum="1AF0724377F7199D" modified="2009-09-22" version="1">MNYIEALNQRYSVKKFDRDKKVSGEKLGNILEAGKLSASSMGLQPYKIIVVESDEMKQKLIPSFHNPSQITTCSHLIVITSKKNVDDSYVDGYFRHISEVREIPLESLDLFRRNIESYTNSPSQNEVASWAEKQAYIVLGNLMFAAALEQVDSCPMEGFKKDIIEEILAVDTEKESVAVTLALGYRAEDDAFQHLKKVRKPQDKLFKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z9</accession>
    <name>C6X2Z9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807096.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02379"/>
    <dbReference type="EnsemblBacteria" id="ACU08812">
        <property type="protein sequence ID" value="ACU08812"/>
        <property type="gene ID" value="FIC_02379"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02379"/>
    <dbReference type="eggNOG" id="ENOG503199U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148569_0_0_10"/>
    <dbReference type="OMA" id="YGYEVNY"/>
    <dbReference type="OrthoDB" id="1802772at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046144">
        <property type="entry name" value="DUF6146"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19643">
        <property type="entry name" value="DUF6146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972261" evidence="1">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="137" mass="16069" checksum="30EA4F5D78AA87EA" modified="2009-09-22" version="1">MKYLIIFLSIFLMAACSPQNKTADNSETTAIKPEKNDEGEWDIEVIDTQYDYFLNAVAKPMSMYSEGYLKSKNAFLVSEWNSYYISGRHRNVIESMIDYDPNENYGLKFEYKLYQVFAYVQWKYGLKLNGLSQTDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X303</accession>
    <name>C6X303_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02383"/>
    <dbReference type="EnsemblBacteria" id="ACU08816">
        <property type="protein sequence ID" value="ACU08816"/>
        <property type="gene ID" value="FIC_02383"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02383"/>
    <dbReference type="HOGENOM" id="CLU_3290008_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="40" mass="4496" checksum="EB40814701B2AAA6" modified="2009-09-22" version="1">MLFFGSLTPKSDVILAKSGSDFERNVSILNINYVVKSNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X317</accession>
    <name>C6X317_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807114.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02397"/>
    <dbReference type="EnsemblBacteria" id="ACU08830">
        <property type="protein sequence ID" value="ACU08830"/>
        <property type="gene ID" value="FIC_02397"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02397"/>
    <dbReference type="eggNOG" id="ENOG50330U3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2315214_0_0_10"/>
    <dbReference type="OMA" id="EGWMARA"/>
    <dbReference type="OrthoDB" id="1917174at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="99" mass="11649" checksum="B3BDB8506CD226C9" modified="2009-09-22" version="1">MDNQDYNNAERAVDQTKWTVNDYADRAKDYIREEKRNNRQATSEGWMARAKDNVRDAWEDTKDALSEAWEKTKDWTDDAADNVKDTGEDVRAEWNKSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X335</accession>
    <name>C6X335_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Fe3+ transport system protein Molybdenum transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02415"/>
    <dbReference type="EnsemblBacteria" id="ACU08848">
        <property type="protein sequence ID" value="ACU08848"/>
        <property type="gene ID" value="FIC_02415"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02415"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094965_0_0_10"/>
    <dbReference type="OMA" id="FAAHLMV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021776">
        <property type="entry name" value="ActD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11821">
        <property type="entry name" value="DUF3341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="183" mass="20479" checksum="FEB211436C5CD655" modified="2009-09-22" version="1">MKLIKQKKKKMSTTKKIYGIYADDDDLLNGVHAFNDKGIAIAEVYTPFPVHGLDKALGLKKTRISDAAFIYAVYGVTIGALVTYYTMNHDWPMNIGGKPSFSWAENMPAFVVPMFELMVFCAAHMMSLTFLIRNKMYPGCPPQNPDPRTTDDKFMIEVLSDDLDGVKQILVDTGVEEITVKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X358</accession>
    <name>C6X358_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807155.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02438"/>
    <dbReference type="EnsemblBacteria" id="ACU08871">
        <property type="protein sequence ID" value="ACU08871"/>
        <property type="gene ID" value="FIC_02438"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02438"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017738_0_0_10"/>
    <dbReference type="OMA" id="NALFIPY"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="18"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="705" mass="77929" checksum="3FC6E324198F5668" modified="2009-09-22" version="1">MNFSHFVLPFEDPVLKFLVVLIIILFAPLLLNKIKVPHLLGLIIAGAAVGPNGFNILTRDSSIVVTGTTGLLYIMFLAGLEIDLAEFRKNKWKSLAFGGYTFIIPFVLGICTAYFVLDFNWLTSFLFASLFSSHTLISYPMVSKMGISRNRAVTVTVGGTMITDILALLVLAVVVGMTTGEVNTAFWTKLSVGIIAFAGIVLIGFPIVGRWFFKKVDDRISQYIFVLVMIYLAALLAELAGIEAIIGAFLAGLALNRLIPRSSSLMNRVDFVGNAIFIPFFLISVGMLIDVKVFFKDFETIKVALAMILISIGGKYMAAIVTQKTFSFTKPEGGIIFGLSSASAAATLATVMVGYNIIIGETEAGEPIRLLNESVLNGSILLILISCTISSFVTQKNAGKILDTDNENTISETDPDDERILLALNYEKTVDAVTNLALLLKSKKNTQNIFAINVINNERNESSEKNAGKILENAVRIGASADVEITPLKRFDNDVQNGISNEIKEHKITDLVIAVNPEKGFSTSLVYNLYNGYLSNFTANTLVYHAVQPIATIRKYIVVFPENAHLESGFFHSLLKVWNIARNSGSKVEFYGDDKTIKVLEKIKKKATIDAAFYIFNNWNEITKVFGKMKDDDAFILFMAKRGMVSYLPQMQNVPVYLNEHFAQRNYLLIFPSRNTNSEYEKLSRDIGNADDFAEIGNIIGKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X376</accession>
    <name>C6X376_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menD</name>
        <name evidence="7" type="ordered locus">FIC_02456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807173.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02456"/>
    <dbReference type="EnsemblBacteria" id="ACU08889">
        <property type="protein sequence ID" value="ACU08889"/>
        <property type="gene ID" value="FIC_02456"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02456"/>
    <dbReference type="eggNOG" id="COG1165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006051_3_0_10"/>
    <dbReference type="OMA" id="FCNRGTS"/>
    <dbReference type="OrthoDB" id="897995at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032264">
        <property type="entry name" value="MenD_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16582">
        <property type="entry name" value="TPP_enzyme_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M_2" evidence="6">
        <location>
            <begin position="201"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="396"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="555" mass="63697" checksum="247D9BB0D5C70901" modified="2009-09-22" version="1">MKQYSSKRSIQILTHLLKEYGIFNIVISPGSRNAPLAIHFSETDEMNCYSIVDERSAGFVGLGMAKSEKKPVAVTCTSGSASANYYPAVTEAFYSNIPLLLLTADRPTHYVDIFDGQTIRQKDIYQQHSYGDFQLLEDSEENADDQNFSLIKKAIDICIEKQGPVHINIPLEEPLYEMVSELPVFPSVEKHLQKKAFTLPSNLIAEWNLSKRIMILVGTRDYSEELEMQLAQLVKNHTAVVLTEASSNLHHDKFFPHIDRYIFNFSEADIKHYAPDLLITIGQNVVSKKIKQFLRKAKPQNHWHIDEVWHPDTFFTLTYKAETKPETFFSQLLKSVTPEPLPFFNLWDVLRDKKDRKHAEYCLKTQFSDFKFFEMLADKIPQNINLHFSNSSAIRYAQLFEFKENNIYCNRGTSGIDGSTSTAMGYAMRNPAQTVLVTGDVSFFYDINGLWNPYIPPYTRIIVFNNGGGDIFKIIPGPDSTNALDEFILTKHQKTAEHVAKHFGFSYTKVDDEDTLSRVLENFFKHDTHPKILEVDTQQIENAAVLKNYFEFLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F1</accession>
    <name>C6X3F1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02534"/>
    <dbReference type="EnsemblBacteria" id="ACU08964">
        <property type="protein sequence ID" value="ACU08964"/>
        <property type="gene ID" value="FIC_02534"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02534"/>
    <dbReference type="eggNOG" id="ENOG5031YMS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066214_0_1_10"/>
    <dbReference type="OMA" id="KEITRNT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005901">
        <property type="entry name" value="GLPGLI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09697">
        <property type="entry name" value="Porph_ging"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01200">
        <property type="entry name" value="GLPGLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="33610" checksum="F00D0FE1C38C54DF" modified="2009-09-22" version="1">MRLIINAMKKLAALFIFYGMIVSAQNNRVIYEYKFRPDSTKTDSLKTEWMYLDISKNGSKYYSKSAFESDSIVKESISKQMASGMRSISVSKRQGGEITYEVEKTYPALKTSLITDIGNDTYKVTEDRKIIWKILPDKKQLAGYMTQKAQTEFAGRKWDAWFTTEVPIQDGPYKFSGLPGLIVEISDDTGGHKLELKGLKKTADKPVEELNTQGRDIPILRKKPIDVTRAQYVKQLKQYQNDPVQGMRELLSRPNSTVKINVSGKEISDPAEILRAMEQNAKNEMASNNNKIELAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G6</accession>
    <name>C6X3G6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807263.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02549"/>
    <dbReference type="EnsemblBacteria" id="ACU08979">
        <property type="protein sequence ID" value="ACU08979"/>
        <property type="gene ID" value="FIC_02549"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02549"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045521_0_0_10"/>
    <dbReference type="OMA" id="PGAKSFH"/>
    <dbReference type="OrthoDB" id="786563at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="492" mass="51109" checksum="157B98422D3AAEE6" modified="2009-09-22" version="1">MKRILISTIAVSALFFNISCDTDFDQDVNDVVVTSGEADFSKYVALGNSLTSGYRDNALYIDGQNESYPAMLAQQMQLAGGGAFKQPLMPNNTGGFTNLPGFPGKYVLSVVNGALSPGPTAPGAALDNITPAGPYQNMGIPGAKSFHLLAPGYGSQAGLANGTANPYFVRFASSATTSVVADAMAQAPTFFSLWIGNNDVLGYATSGGDGSNPITSEAMFTQAYNGLVATLTSNGAKGVVANIPNVTAIPFFTTVPYNPVPLDAASVTTLNQQVFGPLKQILTAYGQGSRLNLVTATQNPLLLKDESLADLSAQITGALAAAGVPAQQAGLMGLIYGQARHATSADLIPLTTSSVIGTAPTSPYAVAPFNKYGVTFPLDDKHVLTVTEKTEVLTATDSFNAVIKAAATAKGLAFVDANAKMMELSKSSGLQFDGVKYTATFVTGGTFSLDGVHLTGRGYALIGNEFIRAINQKYKSNLPMVNVNSYSGVTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3N0</accession>
    <name>C6X3N0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782165.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00560"/>
    <dbReference type="EnsemblBacteria" id="ACU07018">
        <property type="protein sequence ID" value="ACU07018"/>
        <property type="gene ID" value="FIC_00560"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00560"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_4_0_10"/>
    <dbReference type="OMA" id="WTAILKP"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970625" description="SGNH_hydro domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="60"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="218" mass="25235" checksum="41B76EEDF95347AA" modified="2009-09-22" version="1">MKKLTAFLVLLFFWSTATAQTKPAFWNEIQQFKKADAEKLPESNGVLLIGSSSFTMWKDIANYFPGTTFINRGFGGSSLYDLNFYSAELLQPYNPKQILIYCGENDFAGDENLKPRDVLNRFKHFYSDIRKYHPNVPVAYISIKMSPSRKHLWPKFTATNSLIRNFMRRNQNAEYIDITKAMAGKDGQPRNELFLEDQLHMTPEGYKIWAAKMAPHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R6</accession>
    <name>C6X3R6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TonB-dependent receptor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782201.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00599"/>
    <dbReference type="EnsemblBacteria" id="ACU07054">
        <property type="protein sequence ID" value="ACU07054"/>
        <property type="gene ID" value="FIC_00599"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00599"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017617_0_0_10"/>
    <dbReference type="OMA" id="RFINPFP"/>
    <dbReference type="OrthoDB" id="173242at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972277" evidence="2">
        <location>
            <begin position="31"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="3">
        <location>
            <begin position="159"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_3" evidence="4">
        <location>
            <begin position="395"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="841" mass="92986" checksum="EE0D91744C1C4EA4" modified="2009-09-22" version="1">MTDKIEISSMIRKRTLGLTFVLGAASLAFAQQKVNVSGVIADRQNAAVPYASVSFSNKANKLFSDAALTDEKGAYSLSLVPGNYDVTIEAIDYKKSTINKQISAGGNLGVFTVEAEGSATSGKTQDIQGVVITAAAVKPYRVELDKKVYDPSTDIISKGGNLQDVLTNVPSVSVETDGTVSMRGNSNVRFLINGKPSALLGIDSGANALQSIPADQIERIEVITNPSSKFEASGTAGILNIILKKTKGMGFNGSVTGSLGWLPSTNLNTNLSWKKGSWTWFLNGGGGYRESEGRSDNDTRYFDPATGATTSYLEQNSLNKSQNDNYNANAGFNVDLSDKTSFNMSGMIRAYKSENNNTVDNLTYNAARNLESYTQTSALGNGNNLSLQGDLGLDHKFNDQGHNLFLSLSLQKSDNESFENSREFDDSVFTYGSTGDNKTINKTVIGKIDYELPVGEVSKIEAGYRIDHNNNDYDFLNRETEESFPAYTTVDEYSGNTVYKETINAAYAQFKSKIDKLGYQIGLRAENSAIDIDYRSLDGNISNTEKNYTGFFPSVFLSYDLGDTSNQLLLNYSRRINRPRSWFMIPYPTSLANRQNLFRGNVDLNPEYIDSFELGYAIQKRKFTINPTLYYRATTDETRFVVMSENPGSTVLISRPFNIGNDYQYGLDLNATADLLPWWKIMASADLFGYKSEGEYFDAATMIDPLSFEGSGFSTRFRLTNSFKIDKTLSMQVQGFYRGGQETASSITKPMYVLNFGANKTIWNGNGTVAFNIQDILGTRGREMTSFGSTFERESLMRWNPRSFNLSLTYRFKQGEKIDQPKRKKDINSNSSGDDEPQGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y3</accession>
    <name>C6X3Y3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00666"/>
    <dbReference type="EnsemblBacteria" id="ACU07121">
        <property type="protein sequence ID" value="ACU07121"/>
        <property type="gene ID" value="FIC_00666"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00666"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_1_0_10"/>
    <dbReference type="OMA" id="GYNQSEC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZR_2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="228" mass="26452" checksum="11064F36AA3A9A43" modified="2009-09-22" version="1">MLNFSCSKPKIPMLLTDLIFPNRCLECNRIISADELVCGLCFDQIHFTHHHFDENNLLKEECAVLFPVQYAFALMKFEEDSLSRKIVHQLKYGQREKAGKIIAGWTTDRVDIYPKPDLMITVPLHPKKLKKRGYNQLHLFTETLSENFSIPYDHHLIKRNFYKKAQALKDKKHRTETENMFSVTQKIDNKHVLIIDDVFTTGNTMSSVAWEILKAGNNQVSVLVMAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X426</accession>
    <name>C6X426_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_00709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782310.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00709"/>
    <dbReference type="EnsemblBacteria" id="ACU07164">
        <property type="protein sequence ID" value="ACU07164"/>
        <property type="gene ID" value="FIC_00709"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00709"/>
    <dbReference type="eggNOG" id="COG0339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_4_0_10"/>
    <dbReference type="OMA" id="KNFQSAM"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="PTHR43660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TOP_N" evidence="11">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="10">
        <location>
            <begin position="226"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="671" mass="76374" checksum="852969A52FC90B60" modified="2009-09-22" version="1">MTNPLLQKFSTKHSSAPFDEIKEAHFLPAFEELISKSEQEIEEIANNPEDPTFEDVIEALAFSGEQLDVVSSIFFNLNSAETNDEIQKIAQEVSPLLTEFSAKISQNEALFSKIKQVYENKGKLDLTEEQQMLLNETYKGFVRSGALLNESDKEKFKNISVEISKKSLQFGQNVLAETNNYFKHITGEADLAGIPQAIVEQYREDAKERNLDGFVVTLQYPSFIPLMTYAENRELRREIALANGKKSFNNNEFDNQNLIKEITSLKQQKAKMLGYGSYAEYVLEERMAQTPAKVKSFLNELLEKAKPYAEREIEELKVLAAADGIVEMQSYDHAFYAEKLRKAKFDIDDEELKPYFQLEKVQEAVFGLAKKLFGVEFAETTDIPKYHADVKTYEIFEDGAFKALLYADYFPRKGKRAGAWMTSFKNQFRKNGENSRPHISVVCNFSKPTADTPSLLTFQEVTTLFHEFGHALHGILADTTYPNLSGTSVKWDFVELPSQFLENFCYEPEFLKTFAKHYKTGEVLSDHKIQKISDSKNFMEGYQTLRQVGFGLLDIAYHTDADKVGDIKTFETQETLAANLYPANPETAMSTSFSHIFQGGYSAGYYSYKWAEVLDADAFQYFKENGIFNPEVAAKYKKVLSAGGTQDPMKLYKNFRGSEPKVESLLKRAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X438</accession>
    <name>C6X438_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00721"/>
    <dbReference type="EnsemblBacteria" id="ACU07176">
        <property type="protein sequence ID" value="ACU07176"/>
        <property type="gene ID" value="FIC_00721"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00721"/>
    <dbReference type="HOGENOM" id="CLU_3099060_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="51" mass="6029" checksum="01B81F8EA211B17C" modified="2009-09-22" version="1">MMAVRIESLFSVSVWAFGFFQLNIWALKPVNAENKMKKKNSFLTNVHRNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X484</accession>
    <name>C6X484_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782368.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00769"/>
    <dbReference type="EnsemblBacteria" id="ACU07222">
        <property type="protein sequence ID" value="ACU07222"/>
        <property type="gene ID" value="FIC_00769"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00769"/>
    <dbReference type="eggNOG" id="ENOG5033DA8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452437_0_0_10"/>
    <dbReference type="OrthoDB" id="1627853at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972292" evidence="1">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="186" mass="18602" checksum="5593BACD21981AF9" modified="2009-09-22" version="1">MKNSFAIAALTITAIVLGTDNVQAQTVPALTASATTTATITLSDVISIDTGSAAAGGTVGFNYASAADYNTAQTVAQASALKVTSTKQFSVNVKAGGESFINGTNLIPVNVLTIKAAAAPGIMGGKKSDVILTANDQTLVANAPLGSALVLNLDYTIPADKSSSADILGKPAGTYTQTVIYTASTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X485</accession>
    <name>C6X485_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782369.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00770"/>
    <dbReference type="EnsemblBacteria" id="ACU07223">
        <property type="protein sequence ID" value="ACU07223"/>
        <property type="gene ID" value="FIC_00770"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00770"/>
    <dbReference type="eggNOG" id="ENOG5033DA8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452437_0_0_10"/>
    <dbReference type="OMA" id="CMISTAQ"/>
    <dbReference type="OrthoDB" id="1627853at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970648" evidence="1">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="186" mass="18690" checksum="1B56E805AC6CF02E" modified="2009-09-22" version="1">MKKSFAITALTIGAIVLGTDNVQAQTLSATAQTTVNITLSDVISIDAGSAAIGNTVAFNYATAADYNSEKTVNKANSLIVTSTKNFTVKVKAGGANFVHGTTATNLIPVDVLTIKASAAAGTMGGTKSAVVLSAADQTLVTNAPLGSALTLNLDYTIPAAQSSSAKILGKPAGTYTQTVTYTATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B6</accession>
    <name>C6X4B6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">FIC_00801</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782400.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00801"/>
    <dbReference type="EnsemblBacteria" id="ACU07254">
        <property type="protein sequence ID" value="ACU07254"/>
        <property type="gene ID" value="FIC_00801"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00801"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_1_0_10"/>
    <dbReference type="OMA" id="FPGNHHP"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="53"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="319"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="13">
        <location>
            <begin position="579"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU07254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="644" mass="72124" checksum="428729C78788CF90" modified="2009-09-22" version="1">MKKFYVIAISLIILQVFGQKNEEAERKSMISKELLKYSKMIDYNVNPNTLNYDLRYQRLELDLDPAQQFVSGTVTSHFVPNQNISSIYFDLSNALTVSEVKYHGANLPFTQLATKEVKIDFPANIAAATVDSLSIKYSGVPDTGGSAGDAFTISTQGGVPALYTLSEPYGAQEWFPTKQSLNDKIEKVDIKINTPSQYNVASNGKLLSENIIAGGRKLTFWQHNYPIPAYLIALGITNYTKLNDTVGNPPFPFVNYLYPSTTTNSGIMSNIEWTKTVMNTFEQYFGPYPYRAEKYGHMQFGWGGGMEHATMSSMGAWSRGIIAHELAHQWFGDKVTCGAWNDIWLNEGFATFGEHLANEKLLMTNAQFMSYLASEMSYITGSAGGSVYVSDSNLGNTGAIFSGRLSYSKGGYVVRMIKWILGDDAFYAALKDYHSRPDLAYSYARTEDLKNSLLQSTGKDFTEFFNDWVYGQGHPTYQIRWNQTPDQVVRFRVSQTRSHSSVSFFEMPLPIKVNGTGGQVAYLVLNHTSNNQNFANQVTFPVASVQFNYENQILQRNSTVTFDPSVLAVDDETKNAVKIYPNPVKDQLSVSGIKNGVKYEIFSIDGKLVRSGTYESGQPLYVSALMKGVYFFTIDNQKLKFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D5</accession>
    <name>C6X4D5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782419.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00820"/>
    <dbReference type="EnsemblBacteria" id="ACU07273">
        <property type="protein sequence ID" value="ACU07273"/>
        <property type="gene ID" value="FIC_00820"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00820"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082049_6_0_10"/>
    <dbReference type="OMA" id="AGPQINY"/>
    <dbReference type="OrthoDB" id="1739979at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970654" description="OMP_b-brl_2 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="171" mass="18710" checksum="57A5AA2A65D1C62E" modified="2009-09-22" version="1">MKKLFLVGALALFSAVNAQQTKFGINGGMLAGFANAKTPLGDMSDSSVGFYAGFFAEFNAGSNLKVQPALNYLNLDDASAFQIPVMVKYYVLPAFNLQVGPQFTFDLEENPMPDYYNTLNFGLALGTAYDFSEKLFAEARYSFQLNNHLKNAPSGTSVRANYLNVGLGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E8</accession>
    <name>C6X4E8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782432.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00833"/>
    <dbReference type="EnsemblBacteria" id="ACU07286">
        <property type="protein sequence ID" value="ACU07286"/>
        <property type="gene ID" value="FIC_00833"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00833"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_9_1_10"/>
    <dbReference type="OMA" id="YSIYGMK"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="38"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="218" mass="24317" checksum="F04905CC9024DC4F" modified="2009-09-22" version="1">MNSILLIIIGLTAVISFIAFSNREIFEKYKFNVGAILQRKEYVRLISAGFLHGDMMHLLFNMMTLYFFGPIVLEAFGALGFLVVYLGSIVFGNVFSLYLYKNQSWYSAIGASGGVSGILFASIAMIPDLGIYFFFIPIAIPGYIFGFLYFAYSVYMMLNPREGDNIGHAAHLGGAFFGLVYAVALEPERAVQHSLYLAVMALPLMYMAYMVFVKKKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E9</accession>
    <name>C6X4E9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00834"/>
    <dbReference type="EnsemblBacteria" id="ACU07287">
        <property type="protein sequence ID" value="ACU07287"/>
        <property type="gene ID" value="FIC_00834"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00834"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_2_10"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="285" mass="32556" checksum="0E4131FF2E6CE4C2" modified="2009-09-22" version="1">MNMTLHDFRINFKHELSPLYSNSESNELFTVFVHRILGYDRFAQRKFSNETQDENQLQKLTEILKQLKTGMPFQQILGETEFYGLNFFVNENVLIPRPETEELLELAIAEITKLTVKNQSLKILDIGTGSGIIPVVLKKHFPAAELSAIDYSEKALEVARKNADFHQVNINFIHQDYLGGELNGIFDIIISNPPYIGRDENDEISDSVKNFEPLMALFAPAENPLIFYEKIANDCKTHLSDGGMLFLEINQKLGSETRDLFTEVLHEVRLVKDLSGNDRFVVGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K2</accession>
    <name>C6X4K2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, haloacid dehalogenase-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782486.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00887"/>
    <dbReference type="EnsemblBacteria" id="ACU07340">
        <property type="protein sequence ID" value="ACU07340"/>
        <property type="gene ID" value="FIC_00887"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00887"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_1_10"/>
    <dbReference type="OMA" id="NVCTHDW"/>
    <dbReference type="OrthoDB" id="1669868at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="206" mass="24626" checksum="B2A429F572C5E10C" modified="2009-09-22" version="1">MKQNAIKNIVFDFGGVIMDWNPRYFFKDYFNDDERMEFFLRNIATDEWNAEQDRGRTTEEGTQLLIKKHPEWKKEIRAYYDNWTVMLKADLPRNVAVLKKLEHSDYELFGLTNWSSETFPYALENYNFFEIFKGKIVVSGDENLIKPDPKIWMVLLERYNLKAEESVFIDDNPKNIEVAQSMRFHTVHIMDDTDLEAELRQLGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L5</accession>
    <name>C6X4L5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782499.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00901"/>
    <dbReference type="EnsemblBacteria" id="ACU07353">
        <property type="protein sequence ID" value="ACU07353"/>
        <property type="gene ID" value="FIC_00901"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00901"/>
    <dbReference type="eggNOG" id="ENOG5034587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1319797_0_0_10"/>
    <dbReference type="OrthoDB" id="2011839at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24885" checksum="569C38645A599E23" modified="2009-09-22" version="1">MLTLLYITLFTGFIPLAVLVLLKGKTRKNTPAKPFIYLTAAASFYELVFTIILKIDVRAWWTAYDILAFLIIFYYFYKLNVPKYRIIFYVFMALFALVTVPAVFTSAKSLNAFFHVQAIFSGIITLFVMVMTIQWFRDVFKKMEVPNLWDMPDFYYVTGLFIYYSVTFFLFLLSDVIQSEGSQTFLDYWLLNIVAALVLRILLTAGVWKSIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R2</accession>
    <name>C6X4R2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00949"/>
    <dbReference type="EnsemblBacteria" id="ACU07400">
        <property type="protein sequence ID" value="ACU07400"/>
        <property type="gene ID" value="FIC_00949"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00949"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_0_10"/>
    <dbReference type="OMA" id="WFAGSFT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="324" mass="35534" checksum="793B62C1B71E32DF" modified="2009-09-22" version="1">MEKKFRILGAVIFAGIIILGVINLNIGFIDLKISDFFSENAMNSQIAELRTNRVLAMLLAGIAIPTSGFLLQEYFQNPLAGPSVLGITSVASLSVAFYIFYSQDFMLPEFLQNSFLSLSAIAGSVVLMLVLLAFSGRFQDKSFLIIFGFLVSALAGAIVSILQFYAESQSLKNYILWSFGANNQVSSSQILVLSVIVVFSLFLAFKTIKPLIGNSLGTAYAQSLGVNLTQLKFLIIITSSLLSASVTAFLGPILFIGIVVPHFCRMIYNPAKLWQQWLLNMLLGILIMQFFSIISETTQFPLNVITSLFGIPVILAMMLKSRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R6</accession>
    <name>C6X4R6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uridine kinase</fullName>
            <ecNumber evidence="4">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + cytidine = ADP + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + uridine = ADP + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782550.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00953"/>
    <dbReference type="EnsemblBacteria" id="ACU07404">
        <property type="protein sequence ID" value="ACU07404"/>
        <property type="gene ID" value="FIC_00953"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00953"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_1_2_10"/>
    <dbReference type="OMA" id="TTLKPMH"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="5">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="207" mass="23589" checksum="C613D56011ED2C43" modified="2009-09-22" version="1">MLVIGIAGGTGSGKTTVVNKILQQLNVEGVNVLSQDNYYNDNQQLTLAEREVLNYDHPKSIDFDLLIQHVKALKNGEAIEQPLYSFVTHSRTGDHVQVEPKNVLIVEGILVLTNAELLKEFNLKVFVHADSDERLIRRIRRDTQERGRDLQEVLHRYQTTLKPMHQEFIEPSKNEADLIVPNMKQNTVAIDFLSTVINNTLKKTHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X9</accession>
    <name>C6X4X9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782613.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01017"/>
    <dbReference type="EnsemblBacteria" id="ACU07467">
        <property type="protein sequence ID" value="ACU07467"/>
        <property type="gene ID" value="FIC_01017"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01017"/>
    <dbReference type="eggNOG" id="ENOG5032RWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_2_0_10"/>
    <dbReference type="OMA" id="SEFYPNP"/>
    <dbReference type="OrthoDB" id="1986697at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035652">
        <property type="entry name" value="CHP02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="122" mass="14139" checksum="13B52A93042B31AE" modified="2009-09-22" version="1">MINFENNPLLQKTVQFSLDIIEYCELLDEKRKFVISNQLLRSATSIGANAFEAQNPHSRKDFINKIKIAAKEVEETKYWLFLCKHATSYPFNDKLELQITEIGKIIYKILSTSLSKDNPNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z2</accession>
    <name>C6X4Z2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KAP NTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01030"/>
    <dbReference type="EnsemblBacteria" id="ACU07480">
        <property type="protein sequence ID" value="ACU07480"/>
        <property type="gene ID" value="FIC_01030"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01030"/>
    <dbReference type="eggNOG" id="COG4928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523558_0_0_10"/>
    <dbReference type="OMA" id="NTAYKEN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KAP NTPase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="523" mass="62141" checksum="178CB042A8563B53" modified="2009-09-22" version="1">MIIYLKYRNMTIRVKTDKIFNSFSQHINEVKNERILFTSGFGTGKSTFLAEYFERHVHFYNVFKIYPVSYSVSQNEDVFELLKYDLLFQLIENFENEIELQNDDFSSVLAFQFKFLKEAKWTPILFKLIELADNTGRSSVIEKLLHNVKEQYDDFKSKQTNEEEDIYQYLYEQYTKAGSPRENDLITQLIKKLLLTLKKNTAYKENEDDEELIHKQNVLIVDDLDRLDPEHIFRLFNIFSINFGARDIENKFGFDKIIFVCDIVNIREIYSHRYGRKVDFEGYIDKFYSSSPFIFNTNKLIHEILHEFLTAYELPPTVEQFKDNRDLSYNPTYVILKSIINALLSENKINLRTLINTTEFKFEEEIIETGSKQKYYNTQMPIWVVFSILKTIYDSEDYLREILQSLSEKKSKSAFKFHKSLTHIYRDESYKYLVECCLPFIVNHKEIEDSGKEPSYNENVIHNQLIEELNANVEFSIGQSRSSVMRGTDTYFGFKKFYKNNGTEIEVNPFKILQMTFDKITGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X510</accession>
    <name>C6X510_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">FIC_01048</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805783.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01048"/>
    <dbReference type="EnsemblBacteria" id="ACU07498">
        <property type="protein sequence ID" value="ACU07498"/>
        <property type="gene ID" value="FIC_01048"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01048"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_10"/>
    <dbReference type="OMA" id="DAKYGEW"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="3"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="344"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU07498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="463" mass="49520" checksum="2D0C976EF9958D99" modified="2009-09-22" version="1">MNYDIIVIGSGPGGYVAAIRASQLGFKTAIIEKESLGGICLNWGCIPTKALLKSAHVFNYLKHTEDYGLNKIENPGFDFSKVVQRSRGVATKMSGGISFLMKKNKIDVIMGTATVQKGKKVSVADKDGKNTEYSAQHIIIATGARSRELPNLPQDGVKVIGYRQALNLPEQPKSMIIVGSGAIGIEFADFYNSLGTKVTIVEFMPTIVPVEDEDVSKHLEKSLKKTGIEIMTNASVESVDTSGNGVKANVKTATGNITLEADILLSAVGITSNVEGQGFEEIGIQIEKGKVLVNEWYETSVPGYYAIGDILPTQALAHVASAEGITCVEKIKGMHVEKIDYGNIPGCTYCHPEVASVGLTEKQAKEKGYEIKVGKFPLSASGKATANGNTDGFVKVIFDAKYGEWLGCHMIGEGVTDMIAEAVVARKLETTGHEIIKSIHPHPTVSEAIMEAAAAAYGEVIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X534</accession>
    <name>C6X534_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01072"/>
    <dbReference type="EnsemblBacteria" id="ACU07522">
        <property type="protein sequence ID" value="ACU07522"/>
        <property type="gene ID" value="FIC_01072"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01072"/>
    <dbReference type="eggNOG" id="COG3187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058026_2_0_10"/>
    <dbReference type="OMA" id="RMMCPDM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="META" evidence="1">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="1">
        <location>
            <begin position="166"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="281" mass="31722" checksum="72A1F40CC7AB4087" modified="2009-09-22" version="1">MMQNRYCDVTLPIHKNVQLKIKKIIMVKIFNLIAIAALLSGCKAGDAAHEAVERELRGSWEITDLRGNKPKTIKPVRIEFSEDNRVNGFLGCNTVRGTYMADIKHQRIKLNGLATTRMTCPDQNFENEMTKALEDAANFTFEDGKLVLSGDDRSPLATFKKISHPEVTNKYWKVVQLDGKAVTMEASQRQEQYFILRSDGTVNGFAGCNNFTGAYQINDGNRIRFNENMAATMRACPNLGFNERGFLEVFRLADRYTVSGDTLQLIVGKRMPLAVFEAVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X569</accession>
    <name>C6X569_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9, prolyl oligopeptidase active site domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805842.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01107"/>
    <dbReference type="EnsemblBacteria" id="ACU07557">
        <property type="protein sequence ID" value="ACU07557"/>
        <property type="gene ID" value="FIC_01107"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01107"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014586_1_0_10"/>
    <dbReference type="OMA" id="DERNIPW"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973606" evidence="1">
        <location>
            <begin position="24"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="648"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="827" mass="95779" checksum="D34BDF9171F466D7" modified="2009-09-22" version="1">MAIKTHPLFLFLFLHLFSLQVSAQKDELSPKSPFAGKTYDISWVVPSEDLKYLTFQKTYDYSADTLALVSTKHPDKIPYQAPDVYPISVKYTKGGAVFMSGGVTARLVDLTSLKEQVWNGIRKAFYVPSYERIVLFDGKGLRILDAKGRLTEEMTQVSAVQEKDERIFYTQKTAEGDQLMEWTPETKHVLSAVGGENFHVSYCRGPVVIYYHHDSRTGHAKMYLTDRSKQKTYALPEYLDGTPSRPVEVSALRSGRYFVTFATENKKVLQKSDVDIWYGNDNKLENKFYNDEIMTYAIWNPVINEIRPLDYQRFPTHIDTGEGRYLLASDPKQNQDYIRQKIKQKFYRYDTEEDRYEVMGDTGLYQNTDKDGKYLLSHDNDNWVVYTIATNEKRIIAVKDGIDAHEIFFSSDGNFVLFPRLERISAYDLRTGELRETPISSGYTATVAHGLRRGFSLHSFFYRNWYEAGQPLLIKVHNYSTSEQSIGLYRNERFQGLVSSGSDNLTPIAAFPQQKSYLYLRSNYNLPPVLTLNTGFKDRVIYRSNPQDKSVSGARMEKIAYTNSKGVALTGVLFYPSTFDKSQKYPMIVGIYELMHSNSNRYLRDGFAGRVEGINIRYYLDRGYFIYLPDIVFDGRGPGRSALDCVESGVNALRSHKHIDFAKLGLVGHSHGGYETNFIATQSKLFAAYVGGAGNSDLVRSYHSFNYNYTSPFYWQFEEQQYRLFKPFAEDKNLYIDNSPVYHAEKVTQPILLWTGTNDQNIYWEQTMEYYLALRRNDKKVVALFYDKEDHSFEKRKNREDLFVRISDWFDYHLKGIRKDWIHVMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5A7</accession>
    <name>C6X5A7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805880.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01145"/>
    <dbReference type="EnsemblBacteria" id="ACU07595">
        <property type="protein sequence ID" value="ACU07595"/>
        <property type="gene ID" value="FIC_01145"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01145"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="OMA" id="WINQSVI"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="176"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="277" mass="32321" checksum="D29C707E610E650B" modified="2009-09-22" version="1">MEYPIRIFNAENIFEFIAVGRPHHPKTPAFLILKKGKLVFTEGLNSIELHENCVALIDSRRVYELQEISENPEILMIAFAREYTEKLPLKINRLNAFVYFRNELVRHFCLDPKPFSRMWNNAELLQSILESEDPSANREEIIRHLFSSAVYLFGDIISQNAVFSKEKVSRKQQITLQFLKDVGEHYLEEREVTWYAEKQFITSRHLTAILKQVTGQTAGQIIAAYVMKEAKALLSSTDKSIYEISSDLKFSDQYSFSHFFKKHGVESPAAYRRRFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B1</accession>
    <name>C6X5B1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07599">
        <property type="protein sequence ID" value="ACU07599"/>
        <property type="gene ID" value="FIC_01149"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01149"/>
    <dbReference type="HOGENOM" id="CLU_1352954_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="23852" checksum="596702D3C7275AD9" modified="2009-09-22" version="1">MYLYDEVIYKRVSSNFPQQNSTMNNIGLDTSNFWKFICTLSLLVFAFCLSYEPLFLAKHNQEMNLLNENKAKLAAKNGYYLGLTKDLYEEVKDSLKHGDIKYFYYSKSNKTEKDINNQHRDTILYYSNQFSSKPIKEKIDSLNKLNYNYAEGVFLSKTYTFTQNALEKNIAQRSCITLIFGILSLITFIWSLFKWYKSEHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D0</accession>
    <name>C6X5D0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">FIC_01168</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805903.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01168"/>
    <dbReference type="EnsemblBacteria" id="ACU07618">
        <property type="protein sequence ID" value="ACU07618"/>
        <property type="gene ID" value="FIC_01168"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01168"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_0_2_10"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014143">
        <property type="entry name" value="NHEJ_ligase_prk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02776">
        <property type="entry name" value="NHEJ_ligase_prk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="14">
        <location>
            <begin position="86"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU07618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="622" mass="71270" checksum="CA0E9BB692E530E3" modified="2009-09-22" version="1">MLCGTADKPFSSSDWAFEIKWDGYRAVADTRNGIQLYSRNGLSYLEKFRKITNSLKLQNHEMVIDGELVAYDDKGKPNFQWLQRIGENPNLTVIYQVFDLLWLNGHSTENMNLLQRKELLKEALVETEFIKYHDHVVEKGEDFYRLVESLELEGMIAKKIESTYQPGLRSGDWLKIKSLQTEEVLICGFTAPKGGRKKFGSLILGRYLGGELVFCGHTGTGFSDKILVELHKKMEPLIISDSPFEKIPKTNEAATWIKRELVAEIKFTELTDDHIFRHPVFMRLRDDINPKDLSFKEEPKAENNEVPDTVPIKKPAVKRENEQLKKIGKQEVKITNQNKIYFPKDGVIKGDVISYYQSVADYILPYLKSRPQSMNRFPNGIDGMSFYQKDASDEIPSWIETEKVHSESNDKMINYILCNNEATMAYLNNLGCIELNVWTSRVETIDKPDYLVLDLDPSDNNTFEDVIETAQVVKKIMDKGKIDGYCKTSGSSGIHIYIPAGAQYSFDQVKDFAHLMMQMVQQELPDITTLERTLQKRDKGKIYLDYLQNRRGQTLASVYSLRPKNGAPVSMPIEWDELKIGLKPTDFNIENAMERLKTKGDLFKPVLGKGFDMLTAIDLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F8</accession>
    <name>C6X5F8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805931.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01198"/>
    <dbReference type="EnsemblBacteria" id="ACU07646">
        <property type="protein sequence ID" value="ACU07646"/>
        <property type="gene ID" value="FIC_01198"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01198"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017617_1_0_10"/>
    <dbReference type="OMA" id="GHELNID"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973482" evidence="1">
        <location>
            <begin position="19"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_3" evidence="2">
        <location>
            <begin position="295"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="718" mass="81695" checksum="04372FC2A6894175" modified="2009-09-22" version="1">MKKTIIAAAVLCTLCTFAQETKNDTVKTENIKEVVVLARKPTIESKADRTVFNVANSAILTGNTTWDVLRMTPLVNIDNNDQVQAEGNSVTVYINDRKSVFTGKELKEYLKTIAADNLLKIEVITTPSAKYETAGAVINIVLKRNENEGLKGSVSMNNSQSYKNSQSSSVNLNYHKKGFTQSLSGSYNHNNNLQKSYNENLIYADNSLTKITTENSTVWKSPSASSSTEFELDEKNNVGMVVEYYGSANSTLSDAAGEYFINNELQRKYAKTVDANGTNMFLGSNVFYKYYDKEKSRILDLNAGINYSGNENTRTHSTLWDPAAFEGIRTAADDRNREYYVKLDYSQPLPNEGGQLEFGGKMNFRNNVMPFNYFTFEGDTWAEDASRTNTFRYLENLNSVYANFSKTYFKKLETRIGLRYEYISFTIKQDVGSVERKDSYGTLMPDLLLKYSFNENYNLTATYKHSIWRPWFAEFNPFLMPADNGTFQRGNMDLQPNPSDRFGLKLGLYKKYFISANFSTTDQDYWTSYTVEGDRTIAMPTTFYGRVNNYSLYANTNQNFIKNKLNVNLNLGLSYTDNSDFKRRNNFVGMKEHITNFNGSANFSYTNLFDKNINLNGWGGLHSQNWGNSVGSKMNFFHSFGATKLFPATQMEAGIRFNNIFRRPGNDFVTYSPVGTFRNVNKWDWYGVTFTFVKRFGNQKVKENTKTNVEKEGGGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J3</accession>
    <name>C6X5J3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805966.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01233"/>
    <dbReference type="EnsemblBacteria" id="ACU07681">
        <property type="protein sequence ID" value="ACU07681"/>
        <property type="gene ID" value="FIC_01233"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01233"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OMA" id="NPDFAWE"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970702" evidence="5">
        <location>
            <begin position="27"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="119"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="407"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109902" checksum="B68A4E1E7FDD984D" modified="2009-09-22" version="1">MKKKFCRPAGIALAFLLSGVYTTVHAQSRTVTGTVNDGSRPLSGVTVSQEGSSELTTTATSGTFLLRVTGENPVLVFRHPEYGERKMVADRSSLVVSLTEKVNTIQEVVLNAGYYDVKARESTGSIAKVTAKEIENQPVTNVLSAVQGRMAGVNIIQGGGTAGGGYDVQIRGRNSLRTILNSSVNGNQPLYIVDGIPWSSQLTSFYSTTILPMRNINPLNSISPNDIESIEVLKDADATAIYGSRGGNGVIIITTKKGKTGKMRFTVNTGYGLSKVTNKMKLMDTQQYLKMRKDAYTNNGITTLPANAYDINGVWDQTRYTDWQEVLIGNTAENSTIQLSVNGGSERHSFSVSASHTDQTTVFPGDFHYKTNILNSNYEHTSADRRFLLSVSNSVSHLKNNVISSDFTNKSLNLSPNAPALYDASGNINWENNTFSNPVASLNGKYQSTILQFNHAVKLHYDFSGNWKLKLDGGINMQSLEEYNLNPNTMANPAFPAGASSARSSSSRGTSDLLSYIAEPQIAWMKKADHGEWEALAGITYQETSSENTSVTATGFASNALLYNLSAASQISVSNFGDVNYKYAAVFGRANYKYKNRYILNVTARRDGSSRFGPNNRFANFGAVGMAWLFSEEPFLQQFSWLNFGKLRASFGRTGSDLIGDNQFTDTYTVTSSSYNDVPALYPSRLYNPDFTWEKTNKIEVALEFALLNNRLNLTAAYYRNRSSNQLVGIPLSAVTGFSSVQANLDATVENSGWELEASAVSYQQGDTKWETSFNISVPKSKLVSFPGLDGSTYANTYLIGQPTSIVKVFQYEGINPSSGQYVFTDFNNDGKISAPDDAKAIRDIGVKYFGGLQNQISYKNISLSFLLQFVKQISWNYYRYMNTPGNMNNQPAEFANVWSAENPNGVIMPYSPGTVSATNTLIASFKNSTAAISDASFIRLKNIQINYRIPVKSNFVPAASIYLQGQNLLTWTDYIGLDPEFSVSGFLPPLKTISMGLQLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J5</accession>
    <name>C6X5J5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S9, prolyl oligopeptidase active site domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805968.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01235"/>
    <dbReference type="EnsemblBacteria" id="ACU07683">
        <property type="protein sequence ID" value="ACU07683"/>
        <property type="gene ID" value="FIC_01235"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01235"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014586_1_0_10"/>
    <dbReference type="OMA" id="TSENAHM"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="640"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="823" mass="94936" checksum="B9A4FBF9279C34CC" modified="2009-09-22" version="1">MHMMKILMRTACMVLGGALCGQTETAEIPANLIRHYYQMDYQKISPNGRYVAFNKMYDRSTDTIMVVDRKNPDHIIFERGGVFANTAKFTTRSNLFMREGRNAQILSLPSSALRIWKNVSDGFYHSGLKQIILLKNDTLQILSEEGTELKTVADVKDLKKNSDLLYYTVEEAEAYRLTEWNGKTGKVLYTSENAHMDIRHRDASGIFLWDTKEKTGEGELIFKTYGSEVTSSLSGKFPQTVYRAEVSPLANGKYFLQVIVDRPQQNKNAVDVWYGNDTKIQEKFSGDREFKYLIWDPMRDDLLQIDHTELTQNFFAGSARYLLSFDPYFRHNYTTRFKSFNLYRYDTQLNKYDFLINAGTIVFTDEKGTLLLSRRSGGGWNLYNIETLKNRIIQIPDHEMAYFSRDGESILFEGTGKIYLYNLTDGNIRIIPVKEGFRIKVKNGITKDLSPPFSIYRHSYSPSEPVILELYDSENIRNALFTYDGRSVKEIIPPTNDDITSAVWESAHKAFTYVRSNINKPPQLVLKKGKREELVFAGNKSDVEAAGIKSEVISYTNSRGAALKGVLLYPIGFDSGKKYPMVVTVYQKLRYNMNKYLIDGIGSMLPTEGINVRTLLRKGYIVYMPDIVFDERGPGRAAVDCVNNAMDAIQNNRAIDFTKVGLVGHSHGGYETNFIATQSDRFATYVSGAGNSDLVRSYHSFNYNFDRPFYWQYEDGQYQMPGPFTDNKALYADNSPIYHAEKVTGPILLWTGMEDYNIFWEQTMEFYLGLRRNHKRVTALFYPKEGHSFSKVQNKMDLYSRIYEWLDFHLKNQKKEWIEKMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P2</accession>
    <name>C6X5P2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806015.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01282"/>
    <dbReference type="EnsemblBacteria" id="ACU07730">
        <property type="protein sequence ID" value="ACU07730"/>
        <property type="gene ID" value="FIC_01282"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01282"/>
    <dbReference type="eggNOG" id="ENOG50330QI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153095_3_0_10"/>
    <dbReference type="OMA" id="MIANVFI"/>
    <dbReference type="OrthoDB" id="1930578at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="102" mass="11097" checksum="CC0BB03C900D7098" modified="2009-09-22" version="1">MLDLLKDYASKRLDLLKMEATEKSSVSAGTFTYFALAAVAGLFFLILLNVGLGLLIGSWIGNYGYGLLIMAGFYLLIIVIVFAARKSIKNMVANKIINSLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q6</accession>
    <name>C6X5Q6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806029.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01296"/>
    <dbReference type="EnsemblBacteria" id="ACU07744">
        <property type="protein sequence ID" value="ACU07744"/>
        <property type="gene ID" value="FIC_01296"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01296"/>
    <dbReference type="HOGENOM" id="CLU_965588_0_0_10"/>
    <dbReference type="OrthoDB" id="2112402at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="151"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="288" mass="31546" checksum="F5C975031319065B" modified="2009-09-22" version="1">MISIFITILGHIAYGITNVLWKNPRNELGTLPLIIVRSFVCMLIFGLAFIILSAWGVIPYPTVSAMDIVGTLGICAVNYFGLFFFLKSMKHAPVSHTIGFGKIGLVIGIAGGYFVYGEEISLLKVLMAIVVLIGVSMIEFSSQKRPTIISKGLLYAILCKFFWGTAYLYVPFINKLGPILFCAILEFTVCTMSIILFLWKPTKIKVAEISSRTKYEVGLLILLGMVGTFCLNFALANISIIMFAVIGLIEPIIGLVISKVYHKEKLSRIQQIGIAAGVTAAFILSATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V7</accession>
    <name>C6X5V7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806080.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01347"/>
    <dbReference type="EnsemblBacteria" id="ACU07795">
        <property type="protein sequence ID" value="ACU07795"/>
        <property type="gene ID" value="FIC_01347"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01347"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_1_0_10"/>
    <dbReference type="OMA" id="EVAYDIY"/>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="365" mass="40736" checksum="C77BBB70EC3A6776" modified="2009-09-22" version="1">MKVHQAISAIERRIAIRQAEDFDNVGLLCGNTEREITGILICHDALENVVDEAIARDLNLIITFHPIIFSGLKSLTGKNYVERAVMKAVENKIAIYAIHTAFDNDYFGVNYRICEELGLINQQILMPKTNNLTKLEVFVPTSHADAVKNAMFNAGAGNIGFYDECSFSVSGSGTFRPVAGSNPYSGTQNIRENADEELISVIFENFKQNRIVAAMKNAHPYEEVAHNLTALQNENHYWGLGRFGELEEELDVQDFMRFVKEKFNLSVIRHSEPNSKTIKKIGVLGGSGASGIKAALARGCDAYLTGDVKYHDFFLGEGKMLICDIGHFESEQFVTDQLFEILSEIFPKFAVSKSVEKTNPVNYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X0</accession>
    <name>C6X5X0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsgA</name>
        <name evidence="10" type="ordered locus">FIC_01360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806093.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01360"/>
    <dbReference type="EnsemblBacteria" id="ACU07808">
        <property type="protein sequence ID" value="ACU07808"/>
        <property type="gene ID" value="FIC_01360"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01360"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_2_0_10"/>
    <dbReference type="OMA" id="CLVAAYD"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04466">
        <property type="entry name" value="S1_YloQ_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="8">
        <location>
            <begin position="87"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="181"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="309" mass="35126" checksum="8FA01CD690AA4478" modified="2009-09-22" version="1">MKGLITKSTGSWYQVLEQDTGKFFEARIRGKFKLIKTRLTNPLAVGDHVEFSLEQDDVAWITHIEPKKNYLIRKSVNLSKEAHIIASNIDVACFIFTLKFPETSLGFLDRFLACCEAYNIQPLILFNKMDVLSEDEKELVQHIEAIYQNIGYQTLEISSYSQLNLEALQAILKDKVSVFFGHSGSGKSTLVNALQPDLNLKTSEISASQLKGKHTTTFAQMHFWHFGGSVIDTPGVREFAMIDVQKEEIQHYFPEIFALGRNCKFHNCMHINEPKCAVTADLDSGGDLEETRYQTYLKLMEEAEENSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z0</accession>
    <name>C6X5Z0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01380"/>
    <dbReference type="EnsemblBacteria" id="ACU07828">
        <property type="protein sequence ID" value="ACU07828"/>
        <property type="gene ID" value="FIC_01380"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01380"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_1_0_10"/>
    <dbReference type="OMA" id="VVHNSMG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="264"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1567" mass="179256" checksum="ACC891E6FEBFB0BE" modified="2009-09-22" version="1">MFCRNIELFLPKFHLFMYLIFDTETTGLPKNYNAPLTDSDNWPRMVQIAWQLHDRDGNLLENQDYIIKPDGYDIPFNASRIHGISTKMAHAEGRDLREVLIEFGEVLKKAEVVAGHNIDFDYKIAGAEYHRQSLDNILEKIPSADTMELGTDYCKLGGGKNGRYKSPKLEELYTTLFNERFDEAHNAAADVNATAQIFFEMMRLRIIPSEKLRITEPELDEFIRSHPNPFRPFGIIIRRQVAASKKKKKVDFGDSDEIEIGDYFNFHNHSIYSSLQSSTHINELISKAMDNDLKAVGIVDLGNMMGAFKFVSEVEKTNAQIKKTYQTYLENKEKADREGTAFTEKEPRKEPLIPVIGCEFYISDRPEQKQFTKDDPDRRTNVVLLAKNFSGYKNLVKLSSLGYVNGFYFGVPRISRKMIAEFKDNLIALTAGTLGDVPSTVLEFGEQKGEEVFKWWKNTFGEDFYVQIQNHEVEEEEHLNEVLLGFADQYDVKILAQNETFYTNKSDANIQDILYCIKDGEKLSSPVGKGFGKRRGLPSKQFYIKNTDELKQSFIQFPDAFEAYTELLGKFEPYTLKRDVLLPEFDIPEEFLHDEDKTDGGKRGENAYLRHLTYAGAEKRYPEITDEIRKRLDFELEVIAKTGYPGYFLIVQDFCNEARKMGVWVGPGRGSAAGSAVAYCTGITNVDPIEYNLLFERFLNPERISMPDIDIDFDDEGRDKIIKWVVEKYGKNNVAQIITYSVLGGKSAIKDAGRVLDLSIPETNNIAKLIPSAPGMNIAKAFSKFEKLPPEDKVLAQEMKDILANPTDERYDVLYAAQRMEGCIRNTGIHACGVIITPEDISNLIPITIAAKDPDILVSQFDNSVAESAGLLKMDFLGLRTLTIIKHAIKLIKERHGTEIDIDHVPLDDAKTYQLFQEGRTIGIFQYESPGMQKYMRELKPTKFADLIAMNALYRPGPIKYIPNFINRKNEIEETVYDLEETKEFLEETYGITVYQEQVMLLSQKLANFTKGEADTLRKAMGKKDRATLDKMYPKFLEEGQKNNLNVDKLNKIWKDWEAFAEYAFNKSHSTCYALIAYHTAYLKANYPAEYMASVMTNNLNNTKQITMFMEDCKSIGVDVLGPAVNESQYEFSVNEKGQIRFGLGAIKGIGSGPSEAIVDGRKNEKYKNIYDFFEKIPSSQMNKRVAESLVVAGAFDEVDRYHRAQYFDIDITGKTTIERLLRYGQSFQDSKNEIENSLFADFAEEVKIEQPKINPAPEWQNMHMLNKEKEIIGFYLSAHPLDEYRFQYQFLQGALSKKEILEGKKDEPVEIEKIVLAPELAEIADVDEDLVDIPLDVLSEEDDALVEEPVKKAEPKGSFNFLNLDEVDAFKESAFANQQPDLFNNDQLSWKEKQALKNNTPEYMVAGLVTEYTVKDGKNSGEKIAFVTLEDYSGSYGFRLGDRDYMRLREKIEVQRFVIFKIKFAQSRDNRVFVNVAEVIDLKDAFEKFAKKMTVVVDVNDLRKEDIVFFKENLLGNSGEQKLNFLVKNPDDHTVIEMMSVKTQVEINGDLLEVINNMQKFQVFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X648</accession>
    <name>C6X648_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806171.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01438"/>
    <dbReference type="EnsemblBacteria" id="ACU07886">
        <property type="protein sequence ID" value="ACU07886"/>
        <property type="gene ID" value="FIC_01438"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01438"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_4_1_10"/>
    <dbReference type="OMA" id="WHGHSTW"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="228" mass="25046" checksum="B5CF8779DE178FDF" modified="2009-09-22" version="1">MKIQFLGQNCFLFTYNGKTILSDPFYNFGKATSGFDIAAQKIDFVLITHAHGDHTADVKEVLQHHPEAKIIGQPEICGYFDHPNSIDINFGGSAKIDDLKISMVPASHTSSFPDGTYGGEPCGYIFRFSDKNIYFAGDTGVMADMALFPQIFGDIDLAILPIGGHYTMCARKAVFAASELLKTKKVIGCHFDTFAPIKINHDEALKIFEEKGVELVLPALGETFKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X659</accession>
    <name>C6X659_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806182.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01449"/>
    <dbReference type="EnsemblBacteria" id="ACU07897">
        <property type="protein sequence ID" value="ACU07897"/>
        <property type="gene ID" value="FIC_01449"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01449"/>
    <dbReference type="eggNOG" id="ENOG5033CBF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149185_2_1_10"/>
    <dbReference type="OMA" id="TVHEVMD"/>
    <dbReference type="OrthoDB" id="2078040at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045468">
        <property type="entry name" value="DUF6496"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20106">
        <property type="entry name" value="DUF6496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="60" mass="6562" checksum="8A49541092B0638E" modified="2009-09-22" version="1">MATKKYSDKAADKIGDVMHEFKEGKLKSSAGEKVTDRKQAVAIGISEAKQEGLKVPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X680</accession>
    <name>C6X680_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prephenate/arogenate dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806203.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01470"/>
    <dbReference type="EnsemblBacteria" id="ACU07918">
        <property type="protein sequence ID" value="ACU07918"/>
        <property type="gene ID" value="FIC_01470"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01470"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_2_0_10"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="283" mass="30941" checksum="79CBF1AC7C0B4CF7" modified="2009-09-22" version="1">MKITVIGVGLIGGSIALKLKATGFAAYVFGVDNNQSHLQKAKVLGIIDEISSLEDALAASDLIIIAIPVDASKDVLPKIMDRIMPHQTVMDAGSTKAEIVKAVQNHPSRKRFVAFHPMWGTENSGPESALSDSFTGRAAVICDREHSDDDALNTVEKVAANLGMHVIYMSATDHDLHTAYISHISHITSYALANTVLGKEREEETIFQLASTGFSSTVRLAKSHPEMWVPIFKQNRENVLDVLNEHISQLEKFKAALEQENFGMLEGLILNANKIRGILDKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X697</accession>
    <name>C6X697_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806220.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01488"/>
    <dbReference type="EnsemblBacteria" id="ACU07935">
        <property type="protein sequence ID" value="ACU07935"/>
        <property type="gene ID" value="FIC_01488"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01488"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_1_10"/>
    <dbReference type="OMA" id="TPIFMEA"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="441" mass="48094" checksum="BE0987C7AE77E75A" modified="2009-09-22" version="1">MAEYKLILPSMGEGVMEATIISWLFAEGDMVKEDDSVVEIATDKVDSDVPTPVSGKIVKILKQKDEVAKIGEVIAILEIAGEGGAVADQPQEPKHADEVQTDIPQLSEQEIQELDKTLERATPQAFTGDLYLSPLVKNIAQQENISENELKSIKGTGMDGRITKENILAFIENRTSQPAPAVAAPQTVAAPVQAAAPVFAPVKVGEGDEVIQMDRVRKIIADAMVNSKRISPHVTSFIETDVTNVVKWRTKHKDIFEKREGEKLTYMPIFVKAIVKAIQDFPMINVSVDGDKIIKKKNINIGMATALPDGNLIVPVIKNADQLSLSGLAKAINDLAHRARNKKLRPEDTQGATYTISNVGGFGNLMGTPIIPQPQVAIMAVGAIVKKPAVLETKDGDVIAIRSLMFMSHSYDHRVVDGSLGGMFLKHVHDYLQNWDLNTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X699</accession>
    <name>C6X699_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="12" type="ordered locus">FIC_01490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806222.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01490"/>
    <dbReference type="EnsemblBacteria" id="ACU07937">
        <property type="protein sequence ID" value="ACU07937"/>
        <property type="gene ID" value="FIC_01490"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01490"/>
    <dbReference type="eggNOG" id="COG0321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_1_3_10"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="49"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="247" mass="28090" checksum="E31D9A98AA98949F" modified="2009-09-22" version="1">MSAKQNRTLLLEDLGLMNYEDAHSYQDQLMQQIIAMKLANRVKTDEEREKTPNYLLFVEHPHVYTIGKSGDGANMLADSQKLKEIGATFVQTNRGGDITYHGFGQLIGYPVLDLDNFASDIFLYMRNLEEVIIRVIAEYGLTGMRSEGETGVWLDVGKPYARKICAMGVKTSKWVTMHGFGLNVNTDLRYFEYIIPCGIKDKAVTSLKSELEREFSADDISELKTKIKNHFCDVFEAEIVQKTLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D5</accession>
    <name>C6X6D5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane protein probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01526"/>
    <dbReference type="EnsemblBacteria" id="ACU07973">
        <property type="protein sequence ID" value="ACU07973"/>
        <property type="gene ID" value="FIC_01526"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01526"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_0_10"/>
    <dbReference type="OMA" id="HARTYMM"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972374" evidence="5">
        <location>
            <begin position="20"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="28"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="269"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="492" mass="54334" checksum="BFFBE92D44C0F2DE" modified="2009-09-22" version="1">MKIKAINIFLLSGILAAGAFSVQSCNDDWLDLKPEGRPVGDEVPLGGFEASAFGLYSSLRTESGVSDFSYLWTHSIRADDNEKGSDAADAATDGNVFNNFAYVATNGHIKNAWNGHYKIIYEANELINTATESGETGAGTLINIAEARTIRAFCYFQLRRDFGEVPVNLKTIDVPQDEIAPKNTIAEVDAQIVSDLMAAREVLPVEWPSAYRGRVTKGVANTILAKLYLIQKNWPKALEHSMEVINSGMYSLNPSYDAEFTKAGNNSVESIFEVQKTYNYPTKYTNNYYESQGVRGSGVWDLGWGFNVPSAGLVAAYEPNDVRKKTTILVSGGPDIYGTVGLVLPTSPPLAQQYWNGKAYTLPSERAQYAENKNHWENIKFFRYADLLLMAAEAANELGQVASAATYVNMVRTRAGLGATAALNQGTMRDAIKHERRIEFAMESERFYDLVRWGDANTVLAPFGYASRNMYFPIPQEAIDKAQGVLIQNPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G8</accession>
    <name>C6X6G8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806291.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08006">
        <property type="protein sequence ID" value="ACU08006"/>
        <property type="gene ID" value="FIC_01559"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01559"/>
    <dbReference type="eggNOG" id="ENOG502Z7KY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124273_0_0_10"/>
    <dbReference type="OMA" id="FCDRRYD"/>
    <dbReference type="OrthoDB" id="1197155at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025352">
        <property type="entry name" value="DUF4256"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14066">
        <property type="entry name" value="DUF4256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="178" mass="20098" checksum="D8862AE9C2AA8FD7" modified="2009-09-22" version="1">MTSDEILSVLETRFEKNPQRHEGLEWNSIAEKLQANPNKLAILQKMEDSGGEPDVVGFDEKSGEYLFMDCAPESPKDRRSLCYDKAALDKRKENKPKNNALDAAAEIGIELLDEAQYRYLQTLGSFDTKTSSWLKTPENIRNLGGAIFGDYRYGTVFIYHNGADSYYAARGFRGVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC2</accession>
    <name>C6WZC2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ordered locus">FIC_00498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782103.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00498"/>
    <dbReference type="EnsemblBacteria" id="ACU06956">
        <property type="protein sequence ID" value="ACU06956"/>
        <property type="gene ID" value="FIC_00498"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00498"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_10"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="347" mass="37694" checksum="E1F0146EF4103103" modified="2009-09-22" version="1">MSESIILGIESSCDDTSAAIIRGNTILSNIAANQEIHNEYGGVVPELASRAHQQNIIPVVDAALSQANIQQKDISAVGFTRGPGLLGSLLVGTSFAKSLSMSLNVPLIEVNHLQAHILAHFIDDANEKSPAFPFLCLTVSGGHTMIVLVKDYFDMEIIGKTIDDAAGEAFDKIGKIFGLDYPAGPIVDRLAKTGDANAFKFNKPRLENYDYSFSGIKTSVLYFIQKEVKKNPSFIKENLADLCASVQKSIVEILMDKLEKAAKELNISEVAIAGGVSANSGLREAMRANMEKLGWNIYIPKFEYTTDNAAMIAMVAKLKFDRGEFSDLSVSATARYDIEESFTTKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF2</accession>
    <name>C6WZF2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781634.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00009"/>
    <dbReference type="EnsemblBacteria" id="ACU06487">
        <property type="protein sequence ID" value="ACU06487"/>
        <property type="gene ID" value="FIC_00009"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00009"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007706_1_0_10"/>
    <dbReference type="OMA" id="YNLYKIY"/>
    <dbReference type="OrthoDB" id="1442292at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="835" mass="93737" checksum="F536225B412E0D06" modified="2009-09-22" version="1">MKKTILFLLSVTVLSSCSSRKKSDDSTFMKGFFSYYNTLFNSKDALQTELKNRDNAHVDNFYAPYIQLLTYDEQPLGTDLQAGGMFGDDTAPGNIGMGGPGVPGEMAQSNAGIKSGASILEISEAKALKAIAKYSVMKGGEEKNKKIFDANILLAQSRIYQNKPLEALDGLNYVFANMRNDKRIDLARIYQGLAYSKMGDYYRAGEVFADLKNSKKLKKDHQKLLSLYYSEMLLESGKKEEAIAQLEEAYSLNKNSKLRSRIAFLRGQILANLDRKEEARESFVSAYKNANNFEFEVKSQVEIAKTFNGKDDDYEGAREYLEKISKKGTYASRKNEFYYALGIMANNANKKDEAKAFFAQSLKEKMSDPQIRGLSYFEIGRGFFEDSDYLAAGAYYDSALAVMTYQPSKILLQQRSENIKEVSKNYYLIKKNDSILALTRMPEAERIAYFNKVIDAIKTKEAQEELQRKLDERSKGFDTGDYAANSVFAGSQGGFQDFEGGKGGFYFANQSTVAKGESTFKQMWGSRGLSDNWRTSARSNSIEDMKNEAMGIASAPDPRRLEPSFYIEKIPTNSDEILALKNARDTATLGLGRMYEAYFSDTPLASRTLYDLVYAQPQEDTKLQALYSIFAFNYEKDPATAERAKQMILTEFPYTSYAEFVKNPRDNTFAKSSEEVEKIYSQAFDLYSAGQYDESRSMIESALQQYPKDALVPKFALLNAFNSGKTVGKEIMILQLEQIALNYSKTLEGAKAEEMLKYLRSDLTLEMTDEMGNKADAMPAATTPDQPAGDRPAQVQPQGFPRAPGNSETRTPRKPRNGNISQPTIMNPPQEALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI4</accession>
    <name>C6WZI4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric siderophore transport system, periplasmic binding protein TonB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781666.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00041"/>
    <dbReference type="EnsemblBacteria" id="ACU06519">
        <property type="protein sequence ID" value="ACU06519"/>
        <property type="gene ID" value="FIC_00041"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00041"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955349_0_0_10"/>
    <dbReference type="OMA" id="QDCNESG"/>
    <dbReference type="OrthoDB" id="1144846at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="280" mass="29187" checksum="2AF0B42D055CAC78" modified="2009-09-22" version="1">MHHTIQHKKSEERDRRNSALITLFISVLIFLGIFFYKFTKITDKPEEITTMLINFGDNQNGAEQEEPANQEGSVAANTEVTVPEPVQEEVAVTKPEPKVHVPKPVVKEKIITGSNTKVSTPKAEKATPAAKPKTTATKAATANSKTGSGDGKGTAAIGNLIKGRGTKAGTQGTSGTVGNQGDPLGGDGNGDSKIGVDRNLIGFIPGTMGRGGAQPSHSCSASGTISIAYTVDKAGNVISARRSGGISDPCASSAATGWVKQYVKAERANTSSTGTYRITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI7</accession>
    <name>C6WZI7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible conserved transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06522">
        <property type="protein sequence ID" value="ACU06522"/>
        <property type="gene ID" value="FIC_00046"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00046"/>
    <dbReference type="eggNOG" id="COG2733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036718_0_0_10"/>
    <dbReference type="OMA" id="PGWTPRF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="417" mass="47730" checksum="70914111DD9E2215" modified="2009-09-22" version="1">MKTMKDFEKKAQLRKYKMFATGLFVLMAAVFVVTTVLEKNNPAHWIGYIRAFSEAAMVGALADWFAVTALFNYPLGLKIPHTNLIENSKERIGDNLGNFVVDNFLSPKNIRPYIQKMKISGFVGEWLSKERNQDNLVNELSGIVLDILNKLEDSAVIAFIGKKAKEMSDDIKINEIVGNGLVYILDKNDHQKMITNLSKQIKEYVLNNQEVVKSRVQKESFFLIPKFVDNTIAEKITTGLSTFFEEVENDANHSLRDEITQKLYAFSTEIQSAEKWAEEFRNVKNDFLQEDKLQQYAQDIWNSIRKTLSNELLEEHSGLKMYLKKNLSELSANLQTDVKLQHKIDHWVRVTAYKYILKNTHQAGNLISSTVGNWQGKELSEKLELEVGKDLQFIRVNGTIVGGLVGLIIYTVTNFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ7</accession>
    <name>C6WZJ7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781679.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00056"/>
    <dbReference type="EnsemblBacteria" id="ACU06532">
        <property type="protein sequence ID" value="ACU06532"/>
        <property type="gene ID" value="FIC_00056"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00056"/>
    <dbReference type="HOGENOM" id="CLU_2464516_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="88" mass="8854" checksum="1E0178A2BC2B0862" modified="2009-09-22" version="1">MKKSIFMAAAFAAVTLISCKKTETTATDVNADSTAAVVVVDADSLPVISDSSAVGEAMDSTGDAIQEGAQDVKEGAQQATDGDGNITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK1</accession>
    <name>C6WZK1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781683.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06536">
        <property type="protein sequence ID" value="ACU06536"/>
        <property type="gene ID" value="FIC_00060"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00060"/>
    <dbReference type="eggNOG" id="ENOG5032XBA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188455_0_0_10"/>
    <dbReference type="OMA" id="FYQFLWT"/>
    <dbReference type="OrthoDB" id="1904761at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="95" mass="11354" checksum="D3FFAF1EDA7C751B" modified="2009-09-22" version="1">MTMLSSFFPFYQFLWTVYFLIMFLIGFWCIFMFFGYVIPIWLTSGLREYFGKTKPFDPEEVRRKIMTEQEGVELIYSNPKGRGPFLHGPDSHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL8</accession>
    <name>C6WZL8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781700.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00077"/>
    <dbReference type="EnsemblBacteria" id="ACU06553">
        <property type="protein sequence ID" value="ACU06553"/>
        <property type="gene ID" value="FIC_00077"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00077"/>
    <dbReference type="eggNOG" id="ENOG502Z7TA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400484_0_0_10"/>
    <dbReference type="OMA" id="MMNARIL"/>
    <dbReference type="OrthoDB" id="1609968at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="553" mass="62758" checksum="E4B88BA48CF4975F" modified="2009-09-22" version="1">MMNARILEIIKNPDLIEKDDLGRLESEIENHPYIQSIRALQLYGVHRHRPDDYQNILSKTAAFTTDKKILYQFINKVPASQQEPKPVVAEEIAAPVTQISTPFTDIASVPKGELKPVYVNGVLNRILFEGEEDFLERDHAAIDLEQTKETGLIVTQTANKPQDSPTKEVDAVDSAEVKTEQVTDQAETLIENTEPTQHDEQQVPEAPAEETVAPEAEPQAAQSLNFHGTDKFLPEIKSAAKPIQPEAYTVPKAVPNKHEEEMQRLIAEVEAKMKTRKKQTQPEEETVNDTGLDFADVQDFAVTDVILKQESPEIDGNIPTEETSEFTTSETAEKPVVDSVEETVEHREWKPMVFPGTTPDTLIKKNIEREAETSKNTDKQNVEASDEPVAATEESAFNISFFTQKVSSLETEKADELIEDVKKHIEEDAAKEESNVPVFINTWQNWLKIDKNRTEDTETASKEEEKNKAIETFIVKEPRISKLREESDFVVKERSDNISHLMTETLAKLYAEQKLYAKAIKAYQILTEKYPEKKSYFAEQIKIIKDLRQTKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZM2</accession>
    <name>C6WZM2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781704.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00081"/>
    <dbReference type="EnsemblBacteria" id="ACU06557">
        <property type="protein sequence ID" value="ACU06557"/>
        <property type="gene ID" value="FIC_00081"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00081"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136729_0_0_10"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970469" description="TonB_C domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="2">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="27725" checksum="8A79F0872E80A87E" modified="2009-09-22" version="1">MRYYFIFILFLLYSNSFAQDIYEQYPAGQTDYVGGNIQFYKDFHQVLKNKNLQPCENKKEALSFRIVVYPDKKIKYVKSEDSESLEKNKCAFELTKEVAKYLTGWNPAVVDGNKVAAVTSFWIIPHELFQDLPEGYDPVNDMEMATYEGGINNFRKKVFQSIDLSRFTFTGTFRLEVTFIVETDGKMSDVQLAESTGLKAFDDMVIKGISQIRNKWTPGNIHGIPVRYRFRLPLAFKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP3</accession>
    <name>C6WZP3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rod shape-determining protein rodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781725.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00103"/>
    <dbReference type="EnsemblBacteria" id="ACU06578">
        <property type="protein sequence ID" value="ACU06578"/>
        <property type="gene ID" value="FIC_00103"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00103"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_2_10"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="409" mass="45402" checksum="F1D671F2DF830B40" modified="2009-09-22" version="1">MKWAEGLDKLSIFLYLAISLFAVANIYSVDEALGKKQFMFFCISLVVGMVIFAMRTKFFENFSGIFYFSGLFLLIGLFPFGTEILGQKNWYKFGGFTMQPVEFAKIGVALMLANFVSAGDFDLKKKKSLWSSLAIIGVPAIVVLIIPDVGSLLVFTAFFIALYREGLSGWVFGVGAIFAAVFLVALAIDPVYVVIAISLIYVIFLVINGRQMHWSVVSVAAIAGSFLLLAGLAMGAPKILEKMPKHQRERIEVLYKGEKAFRDTSGYNLLYSKTAIGSGGFFGKGYMEGSVTRGKFVPEQETDYIFCTVGEEWGFFGASMLVIFYAVFIGRIYYLSEKQKTTFNRVFGYCFASILLMHFGINLGMVMGLFPTVGIPLPYFSYGGSSLLAFSIMTFIFFKLSYADRNSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW7</accession>
    <name>C6WZW7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781799.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00177"/>
    <dbReference type="EnsemblBacteria" id="ACU06652">
        <property type="protein sequence ID" value="ACU06652"/>
        <property type="gene ID" value="FIC_00177"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00177"/>
    <dbReference type="eggNOG" id="ENOG5034AW4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2843425_0_0_10"/>
    <dbReference type="OrthoDB" id="2024766at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="65" mass="7597" checksum="A6B01C75CCB85FEC" modified="2009-09-22" version="1">MEALIVHPKNQMELNALKSVMKEMGIRYEKFHTRNAKTASQQESKRPEKPAKPARNYKDKPKTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X082</accession>
    <name>C6X082_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781914.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00300"/>
    <dbReference type="EnsemblBacteria" id="ACU06767">
        <property type="protein sequence ID" value="ACU06767"/>
        <property type="gene ID" value="FIC_00300"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00300"/>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_0_2_10"/>
    <dbReference type="OMA" id="DGGNIMF"/>
    <dbReference type="OrthoDB" id="2010888at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="SSF110836"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nfu_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Nfu_N" evidence="1">
        <location>
            <begin position="103"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="292" mass="32300" checksum="BE9CE81469400AE5" modified="2009-09-22" version="1">MRQILIEATENPKVLKFVADYNLLPGSLELDRQSDISEIPLAQKLLNFPFVDRIFITANFIAVAKQDTVEWEFVADSLKNVIEDELIANPRIYLQKKSEKHLIYSEMTPNPMVMKFVSSTELLDGFVEVKSPAEAGEVPLAKAIFDEFGFAKEIFISGNFVAVTKNVSVEWHEVMITMRDFIANYLQNGGAISNIATQKHETPVESSIQRDYTANEQKISDILDEYVAPAVAGDGGKISLIEYDEASKTAKMLLQGACSGCPSSTATLKGGIENILKQFVPELVENVEAVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A2</accession>
    <name>C6X0A2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00320"/>
    <dbReference type="EnsemblBacteria" id="ACU06787">
        <property type="protein sequence ID" value="ACU06787"/>
        <property type="gene ID" value="FIC_00320"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00320"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128043_0_0_10"/>
    <dbReference type="OMA" id="NAHEIVP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="19295" checksum="FC205A439CC68FCD" modified="2009-09-22" version="1">MRQMKIGDKVSAVDDDLKGTVTSVKGGVVVVKDAHGFTHQFEENKLVLQNPELYDHSPTVFKPEIAKPQSKKHTKKHLVLDLHFENLVKNASDYDAFERLFIQKEKLVETISFCRTNRLKKLEIIHGIGDGVLQKMVYDYLHSQTNLEFDDHDFFYHQRGSVLVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A3</accession>
    <name>C6X0A3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ordered locus">FIC_00321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781935.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00321"/>
    <dbReference type="EnsemblBacteria" id="ACU06788">
        <property type="protein sequence ID" value="ACU06788"/>
        <property type="gene ID" value="FIC_00321"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00321"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_10"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="358"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="421" mass="45764" checksum="EE905A924613DAB3" modified="2009-09-22" version="1">MDPIFDLIEQERQRQTHGIELIASENFVSDHVMKAMGSVLTNKYAEGYPGRRYYGGCEVVDEVETLAINRAKELFGAAYANVQPHSGSQANAAVYLAVLKPGDKILGLDLSMGGHLTHGSAVNFSGIQYEANFFGVDRESGLIDYDAMRQKALEVKPKMLIAGYSAYSRDIDFKKFREVADEVGATLWADIAHPAGLIAKGLLSSPFEHCHVVTTTTHKTLRGPRGGLIMMGKDFENTYGHKTPKGETKMMSAVLDSAVFPGIQGGPLEHVIAAKAVAFAEAIDPKFETYAKQVIANARALAKAMITNGFDIVSGGTDNHLMLVDLRNKNVNGKETEKALVKADITCNKNMVPFDDKSAFTTSGIRLGTAAITTRGLKENDMETIAGLINDVVMNLHDESVIAGVRKKVNELMAGKELFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E5</accession>
    <name>C6X0E5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00364"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06831">
        <property type="protein sequence ID" value="ACU06831"/>
        <property type="gene ID" value="FIC_00364"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00364"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_0_10"/>
    <dbReference type="OMA" id="TRENIHR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="322" mass="37624" checksum="AABAE07A73B15950" modified="2009-09-22" version="1">MAANTQTMKFSVIIPVYNVEPYLEECLDSLLAQTYHDYEVLLINDGSTDASGKICDRYSEKDSRITVFHQPNKGVSAARNLGLEHAAGEWICFIDSDDVVESQYLAAFAENISADSDLVIQGIKRIGKVNDVFCLFTQLEKISRETFFDHYLIWPHYFSPCNKTYRRNIIAEHNLRFDESIHFAEDTIFNLDYAGYAKGMFTLLPNLHYIYRFNFDGLATRQIGFHKRAYLFEYVKDKLSRFTPKRDELYWYATPALKMLYVDRTVGNTYSPLKIFVKNHKREVLDIFDGGMFSMKCITFLIRHDCYFLLDIIFKLLYRNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F5</accession>
    <name>C6X0F5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable beta-glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781988.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00374"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06841">
        <property type="protein sequence ID" value="ACU06841"/>
        <property type="gene ID" value="FIC_00374"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00374"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074336_0_0_10"/>
    <dbReference type="OMA" id="NTWITEG"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="34117" checksum="E0FFA3AA14B8B9D0" modified="2009-09-22" version="1">MNKLTVFTPTYNRAHLLPRVYESLKNQTSNNFIWMVIDDGSSDGTDELVRQWQREATFEIQYLYKPNEGMHSAHNVAYANITTPFNVCIDSDDYMPPNAVEIICLAACEIADDDDFCGLIGLDADFNNALIGTKIPKELQKVKLNELYQLHRVKGDKKLVYKTEHIKKIPPYPMFAGEKFVPLDYKYLLLDQNYYLKPLNEVLVIVEYQDDGSTRNMLRQYRRHPKGFAFSRISRVDFGITWKEKAKNAVHLVSSSLFVNDMSLWLKTKHTALVLCAIPAGVVLNLYIRLKTQKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I0</accession>
    <name>C6X0I0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782013.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00399"/>
    <dbReference type="CAZy" id="CBM20">
        <property type="family name" value="Carbohydrate-Binding Module Family 20"/>
    </dbReference>
    <dbReference type="CAZy" id="GH77">
        <property type="family name" value="Glycoside Hydrolase Family 77"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06866">
        <property type="protein sequence ID" value="ACU06866"/>
        <property type="gene ID" value="FIC_00399"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00399"/>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014132_0_0_10"/>
    <dbReference type="OMA" id="WTDSYPY"/>
    <dbReference type="OrthoDB" id="814704at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM20" evidence="7">
        <location>
            <begin position="117"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="884" mass="104084" checksum="05F0707CC7B051E8" modified="2009-09-22" version="1">MKLFFSINFRTKVGENLQLLIIKNQNVEKSCPLTYSKDGNWVAEVDYFSRDITYKYRLTDDSGTILDEEFAVHRLDFPYQYDEFIIHDTWNLKNFPENYLNNKILKNKLSGFKPEKVSVLKKHTHLFRLEAPIYQKNWQIVMLGDHDALGNWEYFKAVPMAQTDFGVWEAALELPANQIIHYKYGLRNSDTGEVFDIEYGENRWATPNTEKNVLQIKADHYFRFKAFEMYHAAGVAVPVFALRTENGFGVGEFNDLKNLADWAKETNLSVLQILPINDTTANYTWTDSYPYAAISVYALHPQYLSLEKLDFAIPEDLLEQFNMEKTELNSLSLIDYEKMISAKWKYITAVFNLNKDEILKDRNFRKFLKENDEWLLPYAAFCVQRDKYKTPDFNSWKTHKKYIPGKIAPFFTAKSKDFSTTMLHAWVQYQLHVQLKEAIDYTHELGISVKGDLPIGIYRHSVEAWTEPDLFGMDFQAGAPPDQFTELGQNWEFPTYNWEAMKADGYRWWKNRFKALEQYFDAMRIDHILGFFRIWRMPVSATQGLLGYFYPAVPVTADEFRSRNIPFNEDRYCKPFINDQILWDEFGMERDAIHNHFMNNHFNGIYTFKEEFDTQRKLTDYFKQNPYGWAEEKLISLCANVLFLIEEKDGEGVYHPRFNVSRTTSYQYLPDWERAAINDLYNDYFFKRQDGLWYQKAMEKLPVILNATDMLICGEDLGFVPESVPVVMDRLAITALKVQRMPSDDVAWYNPKEAGYMNVVTASSHDSSTLRQWWHEDRNLTQQYFRDQLGQAGTAPHNLEPQLAEMIMKQHLYNDAMLAIFPIQEFLATDPALTRAEMDEERINQPAVFPHYWRYRMHLNLENLLDKGDFNNKIAGWVADSNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K8</accession>
    <name>C6X0K8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782041.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00432"/>
    <dbReference type="EnsemblBacteria" id="ACU06894">
        <property type="protein sequence ID" value="ACU06894"/>
        <property type="gene ID" value="FIC_00432"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00432"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_15_3_10"/>
    <dbReference type="OMA" id="VFIWGFT"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="145"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="297" mass="33728" checksum="C1C7411658A3D3F3" modified="2009-09-22" version="1">MYKNSALFRLHVIVFLWGFTAILGKLIHANAHVLVFYRMFFASAILFLFFRVFKKRSLRVPRKLLAQLVMIGGFMGFHWLCFFYSIKVSNVSIALSCLSLSTLFTSVLEPIIFKRKIDISEVIIGIVIVICMGMIFKTEFQYKEGIFFGVLTALFGTIFQVYNGKIYGKTSSGNIIFYEIFSGFLILSLFYMLTGQIWDVIEISYRDLALVILLAGVFTAYPMLESVSLMKYISPFTLILTINLEPVYGIILAFFIFGESEQMSPVFYIASVVMISAIVINGVIKARKSAKTNNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M8</accession>
    <name>C6X0M8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS200-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782061.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00452"/>
    <dbReference type="EnsemblBacteria" id="ACU06914">
        <property type="protein sequence ID" value="ACU06914"/>
        <property type="gene ID" value="FIC_00452"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00452"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101320_1_0_10"/>
    <dbReference type="OMA" id="THHRNES"/>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="150" mass="18033" checksum="CD9EDCA6AC85F780" modified="2009-09-22" version="1">MAYTRILYHLVFRTKSSGKTIPLDHAPELYRYIWGILKNKNCVLYRINGMEEHVHILFDLHPSVALADLVKDIKVASSKWMKQSGLFPEFRGWGIKYCAFTYSIREKDMLINYIKNQQTHHRNESFQEEIHRLWKDAEIEDDIKWFWVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N1</accession>
    <name>C6X0N1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00455"/>
    <dbReference type="EnsemblBacteria" id="ACU06917">
        <property type="protein sequence ID" value="ACU06917"/>
        <property type="gene ID" value="FIC_00455"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00455"/>
    <dbReference type="HOGENOM" id="CLU_3216568_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="44" mass="5024" checksum="87B75A1B0B70F787" modified="2009-09-22" version="1">MNPVLLRKVLMWVAPLAIGYVMKKYEAKRAKKTQDKALARNAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0W6</accession>
    <name>C6X0W6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Divalent metal cation transporter MntH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mntH</name>
        <name evidence="5" type="ordered locus">FIC_01634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">H(+)-stimulated, divalent metal cation uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01634"/>
    <dbReference type="EnsemblBacteria" id="ACU08079">
        <property type="protein sequence ID" value="ACU08079"/>
        <property type="gene ID" value="FIC_01634"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01634"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_2_0_10"/>
    <dbReference type="OMA" id="IATFVNS"/>
    <dbReference type="OrthoDB" id="416257at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="442" mass="48476" checksum="9BF587F10C5C6BA0" modified="2009-09-22" version="1">MNNPNIGWRRPRRADSLPEVFSSVNIPKNAGFWRKMFAFTGPGLMVAVGYMDPGNWATDIAGGAQFGYALLSVILISNLFAMILQHLSLKLGIVAERDLAQACRDHFNPVTNFILWVFCEIAIAACDLAEVIGAAIALNLLFGIPLTWGVVITVVDVFIILFLQAKGFRYIESIVAGLIIVILGCFIYEIILSKPDVFPILSGLVPQKEIITNPAMLYIAIGILGATVMPHNLYLHSSIVQTRNYERTKAGKKEAIKFATIDSTVSLFLAFFINAAILIVAAATFHTTGNHDVADIHDAHKMLAPILGTTFASIFFAIALLASGQNSTLTGTLAGQIVMEGFLNIRLKPWLRRLITRLIAVIPALIVTILYGEQGTTDLLVLSQVILSMQLSFAVVPLVMFTGSKMKMGQFVNKPILKVIVWVIAFIIIVLNVYLLYETFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X123</accession>
    <name>C6X123_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase B</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806421.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01693"/>
    <dbReference type="EnsemblBacteria" id="ACU08136">
        <property type="protein sequence ID" value="ACU08136"/>
        <property type="gene ID" value="FIC_01693"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01693"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_2_10"/>
    <dbReference type="OMA" id="PDAKWKL"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="142"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="401" mass="46072" checksum="CCB58798000E101D" modified="2009-09-22" version="1">MELIHRNLLIGIHDALQETFFEDRKYADKVIERLLKANRKWGSEDRKVVSQIFYDIIRWKKRLEYYMGEGVKPNNIYKLILTYCLWTKTHYKKFEEFDGIKNAEILNKLKKNTVPTKSIEHSIPEWLAETMEKELGPTWEREMNALNEQAPTILRANTLKTTTKELISDLKDENVESSTIRNYPDAVQLVEKKNVFLTSAFKDGLFEVQDASSQKIGELLDVQEGMRVIDACAGAGGKTLHLAALMINKGQIIALDIYAWKLAELKRRAKRAGAHNIEARLIDDNKVIKRLHGTADRVLIDAPCSGLGVLKRNPDSKWKIDQDFIDRIKKEQQQILQDYSKMLKKGGKMVYATCSILPSENSEQVGIFLKNNEEFTLIREEKVMPSDGFDGFYMALIGRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X142</accession>
    <name>C6X142_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">FIC_01712</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01712"/>
    <dbReference type="EnsemblBacteria" id="ACU08155">
        <property type="protein sequence ID" value="ACU08155"/>
        <property type="gene ID" value="FIC_01712"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01712"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_127_1_10"/>
    <dbReference type="OMA" id="FSLIRVW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="539"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="809"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="931"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="439"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="858"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU08155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134369" checksum="3FCB917975AC6A68" modified="2009-09-22" version="1">MTNRITNTMSFKKNLLFGLGLSLLLLLISSVASYISIRNLIESSTMVRNSNKIITDLDHVFSLVKDAETGQRGYLLTGDARFLEPYNRAKDKISDAVTVLSAEISNTHTQSRNLEKLQQSIGSRIEILDRNLNYKRTDNPVTPEQMLSGKIHMDQIRTTVAMMQAEEQAVLKARTDTMNKFASYTPVLIIFSALLAICITLIFFRKVSQDFKEKTLLTEKVEQKNLETENRLIAIENVAAQISGGDYNILLDQNAKDSLGSVAGPLNRMAESLQTSFKTLEEKEWLSSAVAKLNDRMMGEKTMEKLAADILDSITEHTESSVAALYLHQDNRLHLTGSYALSVANTKRTLEMGEGISGEAFRNGKSLLVEDIADDQTTISYASGTTKPKNIIAIPITTYNIPLGVLELGATHEYSPRQIEFLKAVAGNVGLAFHSVQSRIKLQELLEETQAQSEELQSQHSELENINSELEAQSQKLLASEEELRVQQEELLQSNQELEERSALLEEKNMLIEQRNIDIQQKSIELEQSTKYKSEFLANMSHELRTPLNSILLLSKLMTESEDLDEQYVEYAAVMQSSGQGLLTLIDEILDLSKIESGKMTLEIMDVPLAEITDDMRMLFLPMAKDKNLELKVETEAQAPQMLQTDKLRLEQILKNLLSNAIKFTSTGSITLQVSGDEAHTKIIFKVIDTGIGIAKDKMRLVFEAFQQADGSTQRKYGGTGLGLSISRELARLLGGEITLESTEGKGSEFTLTVPVDASKVQEITELRKEEPAVTIVEKTADKPQRFIASHVPQPVDDDRDSITEDDKVILIIEDDTPFAKILLEYARNKNYKGLVAVRGDVGLEMAQQYKPLAILLDIQLPVMDGWQVMEALKSNPETKPIPVHIMSSMKLKQESLLRGAVDFINKPFALEQMQVIFKKLEDALNRGPKKVLIVEENEQHAKALSFFLSTNNITTNIATNVSDSIDSLKKREIDCVILDMGVPDRNAYETLETIKQSEGLEQLPIIVFTGKNLSQGEENRIKKYADSIVVKTAYSYQRILDEAGLFLHLVEEKNKKKHERISGFDNSGELRNILKDKTVLIADDDVRNIFSLTKALEVHGMKVIPAMDGKEALVALEKNPAVDVVLMDMMMPEMDGYESIREIRSAPKYRNLPVLAVTSKAMMGDREKCIAVGASDYISKPVDIDQLISLLRVWLYDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X143</accession>
    <name>C6X143_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806441.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01713"/>
    <dbReference type="EnsemblBacteria" id="ACU08156">
        <property type="protein sequence ID" value="ACU08156"/>
        <property type="gene ID" value="FIC_01713"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01713"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_10"/>
    <dbReference type="OMA" id="IDDDSRN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="123" mass="13534" checksum="654FD6F6602B30B8" modified="2009-09-22" version="1">MKSLKEILIIDDDSKNIFALSAVLKARKYSCVSALSAQEGLTKLKNNKNIGVVLMDMMMPEMDGYEAIAKMKADADLRHIPVIAITAQAMTGDREKCLEAGADGYISKPVDVDELLQQLNKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X148</accession>
    <name>C6X148_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806446.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01718"/>
    <dbReference type="EnsemblBacteria" id="ACU08161">
        <property type="protein sequence ID" value="ACU08161"/>
        <property type="gene ID" value="FIC_01718"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01718"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105002_0_0_10"/>
    <dbReference type="OMA" id="GEHFMIV"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24424" checksum="CDD9A957319844C9" modified="2009-09-22" version="1">MSKIYIFSGLGVDQRVFENIDFGNLDIEFIDWIVPLRHEPIKDYAKRISQKITADQPILMGLSFGGFIAVEIAKIIETKKVILIASAKTCAELPAIYKFIGKLQLNKLVPVAVLKSHSFMTDWFFGTESKSDKMLLKNILKDTDPRFISWAIDEILHWQNESEPKDWVHIHGDRDRILPLKNVKTNFVIKDGGHFMTVNKAKEIEVIIKNILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B4</accession>
    <name>C6X1B4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806512.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01784"/>
    <dbReference type="EnsemblBacteria" id="ACU08227">
        <property type="protein sequence ID" value="ACU08227"/>
        <property type="gene ID" value="FIC_01784"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01784"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006935_0_1_10"/>
    <dbReference type="OMA" id="NLDARYE"/>
    <dbReference type="OrthoDB" id="76759at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973467" evidence="5">
        <location>
            <begin position="22"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="435"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="868" mass="98042" checksum="89A987266908CD61" modified="2009-09-22" version="1">MKIRKLSIAVLFLTSSANLFYGQVTENDTVRKEKNIEGVVIQGNGNRKSETAILGEQKKAIIQKQSMGAQEISRKGISNVEQGLVKITGITTVEGRGLFVRGLEERYNTLLINGLGSPSNNPFQKIIALKQFPTDVVGKLNIYKTFNSNLYADFAGATFDIETLTIDRAFTKLEFGFGFNTQSTFRNFKVNPNAYTMDGYFGLNSKNRQLPGEVKGYVPTNYNFTPQESVNSFKDGWNADNIKALPNTSTEFTTAQKFKVGETGDLGLLLSLNQGSKYEYSEGQKNQFISLQTEGKMNNDLNRKEYTYELESSALVGLGYKNKGLSVALNTIFLQNSANMISDFVGYKDQKEQDAGRRFFRVDQMDLSKFLDVQLLASQKIGDRHLLKVGGSWVKNNFQQPDRKISEGFLTGRPNEVEMTFGGNNLIRQYLDVNGNNYLSGFAEYSVSLGEKGDRSSYPWQLALGYNGFFDHRSNSYRFIASNIDNVDLRTVVVDIDNPQQTYNNYIMNGAFHFKEETNENDYRSNLYQFVNAGYLNLNFKPNDTWDILLGGRVENNLNITRFKEQGDAEFNNLNKNQYFILPSFSVKKALSTKSNIRFAASKTITRPILIEYMPITYINPDNENIIGNKNLKNSENYNLDLKFEVFPTNKELFSVNLFAKKIDHAIERGYTASGNSNGMAITFFNAENAVLAGAELEGIMNLSRISESLSRWSLGANATFMYSNVDRSADQLEQERPVNFAGTLKNRKLQGAAPWTANADLKYEFRNSNNLPHTFSLVYNASGSKIFTVGTSGLDHIYERPFHQLDFVYNAQLTRNWNLKFGLANLLNSTYRLELGEDGYIPLDVRTLTHTDFKRGTTFNFTAGYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C3</accession>
    <name>C6X1C3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806521.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01793"/>
    <dbReference type="EnsemblBacteria" id="ACU08236">
        <property type="protein sequence ID" value="ACU08236"/>
        <property type="gene ID" value="FIC_01793"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01793"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099590_2_1_10"/>
    <dbReference type="OMA" id="WLYVDGD"/>
    <dbReference type="OrthoDB" id="1472440at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="14819" checksum="B702103F801B47A3" modified="2009-09-22" version="1">MICPCCSEKSYEDCCRPYHVGEKHAPTAEALMRSRFSAFAFPNGEYLMETTLPEKRKFHNTNDLQEWGEINTWTKLEIVQKPAQDQVEFKAYYTDEDGQPQLHHELSLFRKLKERWYYVSGKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F6</accession>
    <name>C6X1F6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01826"/>
    <dbReference type="EnsemblBacteria" id="ACU08269">
        <property type="protein sequence ID" value="ACU08269"/>
        <property type="gene ID" value="FIC_01826"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01826"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_3_10"/>
    <dbReference type="OMA" id="RVKMNRV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="200" mass="23567" checksum="B9940063B88CFCDF" modified="2009-09-22" version="1">MRHRGSADALRHLATEKFLEIGLKKNLYSLLKFPEVLSAKEQEFSKLIKDNQGLIIKVSRLYTNSLEDEQDLFQEIVLQLWRSYDTFKGQSKISTWMYRVALNTAITLFRKKTKSPQTDELMDFHHSGYIEDDDEKQQQISLLYKVVKMLPHVERAIVMMYLDDLPYRDISENLGITEVNARVKMNRLKKTLKQLMEKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G5</accession>
    <name>C6X1G5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal ATPase, fused to C-terminal DUF234 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08278">
        <property type="protein sequence ID" value="ACU08278"/>
        <property type="gene ID" value="FIC_01835"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01835"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_2_0_10"/>
    <dbReference type="OMA" id="YNEDKFH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="479" mass="55712" checksum="82567F6EADD1BC30" modified="2009-09-22" version="1">MAEYNFLQMSGLIGRTYELGLLKETLNTDKSELIAVYGRRRVGKTFLIREFFKNKIIFEVSGLYHGSMRDQLSNFAKEINKKSKKNNTENPQNWFDAFLLLEQRLDRQKSAGKKVVFIDEFPWMATARSKFLTAFEHFWNSYCTKRNDLIIVICGSAASYMLQKIIRNKGGLHNRITRQIRLLPFNLHEADLFLKSRGIRYTQYDVAQIYMAMGGVPHYLEKLQKGLSVAQNIDELCFTKDGLLRTEFDQLYASLFDDSNKHLLIIRTLAKSNKGLTRKELLDQTRLPSGGDISLKLAELIESGFVTEYNYYGNKIQLTLYRLSDEYSKFYLKFIQQNQNSGPGTWQRLQKSASYASWSGFSFETVCLKHISQIKKALRIDAIYSVNSSWFNANAQVDLLIDRDDNIMNVCEMKFYNAPFAIDKKYYLNLKNKIAELQQYTTTSKNIYLTMVTAFGLKENEYSRELVENRVEMKNLFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K5</accession>
    <name>C6X1K5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806603.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08318">
        <property type="protein sequence ID" value="ACU08318"/>
        <property type="gene ID" value="FIC_01875"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01875"/>
    <dbReference type="eggNOG" id="ENOG5033ZEJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048687_0_0_10"/>
    <dbReference type="OrthoDB" id="1567521at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973478" evidence="1">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="272" mass="28327" checksum="2144431EA0ACD48B" modified="2009-09-22" version="1">MKKKLLIAFTAVLAMFTANAQTTTWDFSNDSTNWPLNSGIGNNPIVKQGLGMYPIATNTNFGAITNSSQVSFSDGYVATGNRLQTNGGGSADEGTYKPKQRYFFVQVSGAATVKLWYKSGSGGAVRSAYVSDGNSVLYGSAATSPAASPADTAILTANIPTAGTFYIYTDAAINFYKIEVTGASVVTTLSSNTLSTSGNAATKVSANAFADGGNVYVSNVSGDTKVNVFTANGQLVKALNTKSDVNFALKTGVYIVNLQSDKGVKSQKVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P4</accession>
    <name>C6X1P4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyguanosinetriphosphate triphosphohydrolase</fullName>
            <ecNumber evidence="2">3.1.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.5.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806642.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01915"/>
    <dbReference type="EnsemblBacteria" id="ACU08357">
        <property type="protein sequence ID" value="ACU08357"/>
        <property type="gene ID" value="FIC_01915"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01915"/>
    <dbReference type="eggNOG" id="COG1078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_0_0_10"/>
    <dbReference type="OMA" id="FSHAMEH"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="51"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="403" mass="46829" checksum="BE311D2E890EFF2A" modified="2009-09-22" version="1">MTNKFKIINDPVYGFIKIPYEILYDVIEHPYFQRLRRISQTGLLNLIFPGATHTRFHHALGAMHLMFTALETLKLKGVEVSKEEEKSAMLAILLHDIGHGPFSHALENMLMHSWHHEKLSLLLMEKLNEQFGGELSMAIQMFKGQYHRKFFNQLISSQLDVDRLDYLKRDSFYTGVSEGNVNTQRIISMMNVSDDELVIDAKGIYSIENFLTARMFMYWQVYYHKTSALAEHLLVKILSRAKTLVFEGKTLPASKNLNYFLNKKLFENATEEDIFRFTQLDDTDVIQAMKTWVDNDDFMLSYLCKCIIRRNFPKSIISSKPFDTEFIKEKIERTNTVFKIDIGSQLVDQISISLLPYNTETQPIYLLQKDGCKITLECSENQILSSAINQPNTKFILAFPREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R7</accession>
    <name>C6X1R7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806665.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01938"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08380">
        <property type="protein sequence ID" value="ACU08380"/>
        <property type="gene ID" value="FIC_01938"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01938"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072074_1_0_10"/>
    <dbReference type="OMA" id="WLEGFSE"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="33105" checksum="98AD8D8BCE603AD2" modified="2009-09-22" version="1">MVVGEKIDILFGIVTYGQNFWNSTSFKSLYNSYQSHNTEKPLILFVFDNTDKGHWDIESYSEEYPDCIVEYHHDPANPGISYAYNFIANFAKRKNIPFVAFLDQDTSLPQEFYKIYLQTITDDSSLRIAAPKVYTRKGLMSPSKICHYRSFFINQIDNASIPLKNITCINSGLLINTIFYFQCEGYNKKLRLDFCDHDFMERVAMNTDQLPIIPIALNQDFSAETNSTQNALHRYRLFLQDMKVFRRNKNKALFFVMVDFPHVIKQSLRHKTCGFLRMRFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S6</accession>
    <name>C6X1S6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806674.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01947"/>
    <dbReference type="EnsemblBacteria" id="ACU08389">
        <property type="protein sequence ID" value="ACU08389"/>
        <property type="gene ID" value="FIC_01947"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01947"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_2_10"/>
    <dbReference type="OMA" id="THHKKIM"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="310"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="646" mass="74237" checksum="C5954663DFA40D54" modified="2009-09-22" version="1">MGFRKTWKKKIYSGDNLMNLSDVRYLPRWVILTIDILFVSCAIFFSCYLIDKLSFGAQPVFYNRLNMYLLIMGISVFFMFVFRTYSGIIRHSTFIDLFKLFLASFCTSIAVGFISFTYFFITGERMIYMSVPFLTIFFATSFMLLFMLRLFVKEFFHLIREFRRSTLRKRILVLGIDEQSVAIARAVLDNPNLPYYIVGFLTQRHDYRLANLLGKPIYSREKLEKHTKDELLIDGVLLVKEMMTKEEMNSWVNLFLEKDLKILKAPSVQKLRSTDLEGSIRSLQIEDLLNRKPIHIENEDLKSRHFGKTVLITGGAGSIGSEIVRQVAQLEPNLIVILDQAETPLYELEIDMRNKFPMIQFKFVLADISNRHRLEPLFQKYKFSMVYHAAAYKHVPLIEENPHEAILVNILGSKNLSTLASQYQVNRFVMISTDKAVKPTNVMGASKRAAELFVQALQNTPNNKTKFITTRFGNVLGSNGSVIPHFKKQIEAGGPVTITHPDIVRYFMTIPEACDLVLQAGTMGQGGEIFVFDMGEPVKILDLATRMIKLSGFEPHIDIKIIYTGLRPGEKLYEELLSDDATTLPTHNEKILISKDSDMEFTDIEHLTDHIIEAAVRHEKVEVVQILKDIVPEYKSNNSIYEVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V5</accession>
    <name>C6X1V5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806703.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01976"/>
    <dbReference type="EnsemblBacteria" id="ACU08418">
        <property type="protein sequence ID" value="ACU08418"/>
        <property type="gene ID" value="FIC_01976"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01976"/>
    <dbReference type="eggNOG" id="ENOG502Z7RU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077968_0_1_10"/>
    <dbReference type="OMA" id="LHFYDFW"/>
    <dbReference type="OrthoDB" id="750409at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="220" mass="25279" checksum="66E510D8E0F62E39" modified="2009-09-22" version="1">MAGLTSSTIGRKYAMALSAMFLLIFLIMHLTVNFLSVFGPDAFNTASDFMGYNPLIQFIMQPVLGFAVIFHFVLGFILEIRNRKARPVGYAVNNGSANSSWMSRNMLISGLVVLAFLALHMYDFWWHEINFKYIERNEIDNMRYWGELHERFANVWRVLLYVVAFVLLGLHLAHGFQSSFQSIGARHPKYTPTIKAFGKWYSILIPAGFIFIAVFHYVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X235</accession>
    <name>C6X235_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein FIC_02056</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02056"/>
    <dbReference type="EnsemblBacteria" id="ACU08498">
        <property type="protein sequence ID" value="ACU08498"/>
        <property type="gene ID" value="FIC_02056"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02056"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_3_0_10"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="260" mass="29380" checksum="F88CD9B7ED542DC3" modified="2009-09-22" version="1">MLFYLFLQSTLKDNMGRAFEYRKASKMARWDKMAKTFSKIGKDIALAVKAGGPDPEANPALRRCIQNAKGANMPKDNVERAIKKASGAEAENYEEVTYEGYGQGGVAFFIECTTNNTTRTVANVRAIFNKFDGNLGKNGELAFVFDRKGIFTIDRSLIKMAWDDFEMEMIDGGAEDIDSDEEEVMITSAYEDFGAVAHKLDELGIEVKAAELQRIPNNTKEVSEEQFKANMKMLDRFEEDDDVQNVYHNMEMAEEHLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X237</accession>
    <name>C6X237_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ordered locus">FIC_02058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02058"/>
    <dbReference type="EnsemblBacteria" id="ACU08500">
        <property type="protein sequence ID" value="ACU08500"/>
        <property type="gene ID" value="FIC_02058"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02058"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_1_10"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="155" mass="18220" checksum="04CB81CC58778BA2" modified="2009-09-22" version="1">MFKMKIEKSVTILNRRARFEYELLEEIEAGMVLTGTEIKSLRSSKASITDAFCQFIDGELYIINMMIDEYKLGTFYNHKTKRERKLLLHKTELKKFEKKLKDVGNTIIPLKMYINAKGKAKILIAVGRGKKLFDKRESIKDRENKRNIDRILKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X266</accession>
    <name>C6X266_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806813.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02092"/>
    <dbReference type="EnsemblBacteria" id="ACU08529">
        <property type="protein sequence ID" value="ACU08529"/>
        <property type="gene ID" value="FIC_02092"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02092"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_2_1_10"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="6">
        <location>
            <begin position="147"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="308" mass="32480" checksum="062233420554359F" modified="2009-09-22" version="1">MKVTVVGAGAVGASCAEYIAMKNFAAEVVLVDIKEGFAEGKAMDLMQTASLNGFDTKVTGTTGDYSKTAGSKVAVITSGIPRKPGMTREELIGINAGIVKEVTENLVKHSPDVIIIVVSNPMDTMAYLVHKTSGLPKNQIIGMGGALDSARFKYRLAEALECPISDVDGMVIAAHSDTGMLPLMSKATRNGVPVSEFLSDEKQAYVEEETKVGGATLTKLLGTSAWYAPGAAVSVMVQAILCDHKKMIPCSLMLDGEYGENDICLGVPAIIGKNGVEKIVEISLTDAEKEKFATAAKAVREVNGDLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X269</accession>
    <name>C6X269_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cysteine synthase</fullName>
            <ecNumber evidence="4 9">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_02095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4 9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806816.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02095"/>
    <dbReference type="EnsemblBacteria" id="ACU08532">
        <property type="protein sequence ID" value="ACU08532"/>
        <property type="gene ID" value="FIC_02095"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02095"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_10"/>
    <dbReference type="OMA" id="FWDSGER"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="309" mass="33836" checksum="4042D018D2B4BD13" modified="2009-09-22" version="1">MKLNTVLEAIGKTPTVKINNIFDKNVEVWMKLERQNPGGSIKDRIALSMIEKAEKEGKITKDTLIVEPTSGNTGVGLAMVCAVKGYKLVLVMPESMSVERRKLMSSYGAKFVLTPRELGTSGAVKKAMEMAEELDNVWIPQQFENEANLEIHRNTTAQEVLEDFPQGFDYLITGVGTGGHISGVTEILKQKFRDLKSFAVEPKDSPVISGGNPGPHPLQGIGAGFIPKVLNTGILDGTIQVEKEEAYEFTKRLAREEGILAGISTGASLAAINKKLAEIPEGSKILTFNYDTGERYWSVEGLFEENLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X276</accession>
    <name>C6X276_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="10" type="ordered locus">FIC_02102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02102"/>
    <dbReference type="EnsemblBacteria" id="ACU08539">
        <property type="protein sequence ID" value="ACU08539"/>
        <property type="gene ID" value="FIC_02102"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02102"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_10"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="653" mass="70229" checksum="BD33106AF3547699" modified="2009-09-22" version="1">MLGIKLEKATSNKLKIKNIHTMSKIIGIDLGTTNSCVAVMEGKDAVVIPNAEGKRTTPSIVAFTEDGERKVGDPAKRQAVTNPTKTVYSIKRFIGTHFNDDAKEVSRVPYQVVSGPNDTVKVKIDDREYTPQEISAMILQKMKKTAEDYLGQEVTRAVITVPAYFNDAQRQATKEAGEIAGLTVERIINEPTAAALAYGMDKAHKDQKIAVYDLGGGTFDVSILDLGDGVFEVLSTNGDTHLGGDDFDDVIINWMADEFKADEGVDLKSDAIALQRLKEAAEKAKIELSSASQTEVNLPYITATATGPKHMVKTLTRAKFEQLSADLVRRSMEPCKKALSDAGLSISDIDEVILVGGSTRIPIIQEEVEKFFGKKPSKGVNPDEVVAIGAAIQGGVLTGDVKDVLLLDVTPLSLGIETMGSVFTKLIDANTTIPTKKSETFSTASDNQPAVSIRVGQGERPMFNDNKEIGRFDLADIPPAPRGVPQIEVTFDIDANGILHVSAKDKGTGKEQSIKIQASSGLSEEEIARMKREAEENASSDAKKKEEVEVLNKADGLIFQTEKQLKEFGDKLSADKKAAVESAHAELKTAFDAKDMGSIKTKTEALDAAWMAASEEMYAAGQQGQPGADPSQGNAGANSSADDVQDADFEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X299</accession>
    <name>C6X299_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein/thioderoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806846.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02126"/>
    <dbReference type="EnsemblBacteria" id="ACU08562">
        <property type="protein sequence ID" value="ACU08562"/>
        <property type="gene ID" value="FIC_02126"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02126"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633055_0_0_10"/>
    <dbReference type="OMA" id="LPWINDA"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973493" evidence="1">
        <location>
            <begin position="19"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="291"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="426" mass="48213" checksum="259C725147170ECB" modified="2009-09-22" version="1">MKKVIVTTCLLVLTNLSAQFKINIETAPSFTPKEVYLYTLSGSKDMLHSKAERKGNAWQINVDKPYTGMMKLYFPESNTSVNFISENKDVKLKFESINGKIANIQYLDPSNAVMNSMQDAQQKKEYILPALHQIKDYYQENTDFRKALNSEINRLSAGQLNVAAHPFVNYYQTNYAKYVEKKPSKTLTHDEIIHFLSNSGDMLETSSLMRPVLVSYLNVGPSTNLVADVDKLLKAVNTETPRGQTVMSELIEIFDIYEMTDLKDKYLTEAKNLKCTINDRLSRTIEINKNTEIGASFANHVFTQPTNTTAKSVYDVKSDRKVIVFWASTCSHCEADLPKLIEKYSTMKSKNIEIIAFSLDSDKVAYGNKVKSLPWINDAELKGWYSTSAEKYNVHATPTYFVLDGANKIIAKPSHASDVISYLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A2</accession>
    <name>C6X2A2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent Clp protease ATP-binding subunit clpX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806849.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02129"/>
    <dbReference type="EnsemblBacteria" id="ACU08565">
        <property type="protein sequence ID" value="ACU08565"/>
        <property type="gene ID" value="FIC_02129"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02129"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_10"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="393" mass="44055" checksum="617FE80325ED5846" modified="2009-09-22" version="1">MNSNQCSFCGKKRNEVQVLISGNEGFICENCIEQAHAIIKENNTSESFAPADSIAELKKPKEIKTFLDQYVIGQDQAKKQLSVAVYNHYKRLLHAKDENREVEIEKSNIIMIGETGTGKTLLAKTIARELNVPFCIVDATILTEAGYVGEDVESILSRLLMVADYDVEKAEKGIVFIDEIDKIARKSDNPSITRDVSGEGVQQGLLKLLEGSIVNVPPQGGRKHPDQKYIQVNTQNILFIAGGAFDGIKEIIERRLNKQAIGFSAEKLNKTEDEDYILSQLNAIDLRKFGLIPELLGRFPIVTYLEKLTKETMVRIMKEPKNSIINQFVELFKMDGVSLQFTDEAVDAIVEETMDKGLGARGLRGTTEKVLEDYMFDIEAQEEVVLNKDNVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B3</accession>
    <name>C6X2B3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenical-resistance protein ACR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806860.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02140"/>
    <dbReference type="EnsemblBacteria" id="ACU08576">
        <property type="protein sequence ID" value="ACU08576"/>
        <property type="gene ID" value="FIC_02140"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02140"/>
    <dbReference type="eggNOG" id="COG0798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_10"/>
    <dbReference type="OMA" id="ISAKWYD"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="348" mass="38933" checksum="DF1FC588DAB2E887" modified="2009-09-22" version="1">MQTQLKFLDRYLTLWIFLAMIFGVLLGHFFPGIKNLNSSLTTGSTSIPLAIGLILMMYPPLAKVDYTLLPKAFQDKKALTLSLILNWLIGPVLMFALAIIFLRDEPDYMIGLILIGLARCIAMVIVWNDLAGGNREYGAMLVALNSIFQVFTYSFYAWLFINFLPGKLGLGNFNISVPIADVAQSVAIYLGIPFLLGFVSRYLLIKIKGKNWFERKYVPLISPITLYALLFTIVLMFSLKGDTIMELPLDVIKIALPLVIYFLMMFFISFFINKSMGVAYDKNASVSFTATGNNFELAIAVAIAVFGIHSPQAFVGVIGPLVEVPVLILLVKISLFLKRKYYRKTAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2C9</accession>
    <name>C6X2C9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.262</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.262" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806876.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02156"/>
    <dbReference type="EnsemblBacteria" id="ACU08592">
        <property type="protein sequence ID" value="ACU08592"/>
        <property type="gene ID" value="FIC_02156"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02156"/>
    <dbReference type="eggNOG" id="COG1995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040168_4_0_10"/>
    <dbReference type="OMA" id="TAQVVMM"/>
    <dbReference type="OrthoDB" id="1414545at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="363" mass="40186" checksum="6C41F87E54C35062" modified="2009-09-22" version="1">MSSRPHKVRVGISIGDFNGIGPEIIMKTLKDKSITDFFTPIIFGSGKLFTYQKNIFKLQINFNYITEALQAQSDKINMVNLTADNVNVDLGKPTEESTRMAIESLEAATDALVRGDIDVLVTAPINKDEMIKHGFAHAGHTGYLEEKFQKKGLMFLVSEGLKVAVSTHHIPISQVAENISKEKIKKQIKILNQCLIEDFQISLPKIAVLGLNPHAGDGGVIGNEEIEIIQPAVKDVFDNGILAFGAFPADSFFQPSKYTKFDAVLAMYHDQGLAPFKTLAYEEGVNYTAGLPYIRTSPDHGVAYDIAGQNLADEQSFSEAIFMAIKIFKNRQEYNDLMANRMKPRRSTVGSGVDEDLPRENSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E1</accession>
    <name>C6X2E1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative protease IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806888.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02168"/>
    <dbReference type="EnsemblBacteria" id="ACU08604">
        <property type="protein sequence ID" value="ACU08604"/>
        <property type="gene ID" value="FIC_02168"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02168"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008856_1_1_10"/>
    <dbReference type="OMA" id="DPKGQYL"/>
    <dbReference type="OrthoDB" id="1318587at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="123"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="367"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="584" mass="64920" checksum="5A50F07DD5B4E7B6" modified="2009-09-22" version="1">MKGFLKNVLANLVAILLLGGFFIMFVILMVAYSAITDSNKSAIPNNSVLTLDFKTNIIDSPLEDSDKIFDFAEKQNNIMVYDMVEAIQKAETDDKIKGISIETDGLSAGMTQIDNIRTALQNFRKSGKFVYAYGNTVSQSAYYLGSVADRYYLNPAGGIDLKGLSTEVLYLKSFAEKFGIGIEVIRHGKYKSAVEPFLRDDMSPENKEQLSTLLTDLWMPTARNIASSRKMDTAQFRTAVDSLYGAIPDLSLSHKLADKLIQKSEYDNLLKTKLNLKEKDKLNNISFNKYIGSYKEDNIKKDNQIAVLYASGAIYSGEGIDGIYSEDLIKEIKKLTKNEKVKGVVLRINSPGGSANASDEILFELQQLKAKKPLIVSFGDYAASGGYYIAMAADRIYAEPNTLTGSIGVFGVFPYFKEIANKNGLSAHSVNTNANSNMFSTINGITPGGAAVMQKSVEMTYKRFVHFVTQNRNRSFAQIDEIGGGRVWSGIRAKQIGLVDEIGNLNDAVKFAAQQAKLKDYNVASYPKKVSQFEQLFKDMDQEQLTTKLLKSKLGQEKFMIYEQFTNPKFQGGVMMEMPFKINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J8</accession>
    <name>C6X2J8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806945.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02226"/>
    <dbReference type="EnsemblBacteria" id="ACU08661">
        <property type="protein sequence ID" value="ACU08661"/>
        <property type="gene ID" value="FIC_02226"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02226"/>
    <dbReference type="eggNOG" id="ENOG50330AT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1270739_0_0_10"/>
    <dbReference type="OrthoDB" id="1400493at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="217" mass="25032" checksum="B183604CCDB4E3E9" modified="2009-09-22" version="1">MKTDKSQDKYSEIFQELREEKMNWDFEDFLAEAEKDENSIKTPEKKSASFPKVYWMAASVVLLASLGVFINYSNEQNIDEQDQFVKTEIIKNKENFNSENGYAALQQNDSIKTDSLKNDAEVSTDANVLDKILPKRGRIKRNSRPVYVRNSTPEKSAEKPVETTPDYESNYVIINGQKIENEQEAIDVAKYSFRILSDNVTKTVAQTDVLNNYHDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M0</accession>
    <name>C6X2M0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02250"/>
    <dbReference type="EnsemblBacteria" id="ACU08683">
        <property type="protein sequence ID" value="ACU08683"/>
        <property type="gene ID" value="FIC_02250"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02250"/>
    <dbReference type="eggNOG" id="ENOG5033Q8R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243298_0_0_10"/>
    <dbReference type="OMA" id="ISWEPLI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1627" mass="182103" checksum="31B98B6AD0E64A0C" modified="2009-09-22" version="1">MPDLSKTAIELLRDLDLAAAQRLQPQHLEALLESIQKSTVAQAQTRTLRASKIAHESGRIEDFIKIRRRAPITTPERPEYEVEQSSDVFERSGPHQIFDLNKVFTVPDKRLGPFPSADGPEIFYNFYKYIDDFKVFFQNDTKAALVIPVKLPRLMALNTRVSTLTLSKGNIWIRADLLDPAAPNSTYIGVRLISGTLSLGGTFVVASNAVQVPRLALLDLDLNPDNSYVPEITTVGLDGKNSKFEPTAKLHLKSNRGRFMVAGIQRFAVNAIGWQCNFSTTDHTFMWDAEKKYMCLTLTPDRNRFAAGDSESDLYEVNGEARLDNSLWMLPSRILQNNQSVEVKFNGVLGLHIGKGLRTSWDGLKMQDTQVLVNEAQLMIYNGFFYIFSEAADYSFLRDHLTMWQKSAENTARMELDVRFMNYKTLQILSQSDSGDGVSCFADTEFLIDKPLRADNTPVHPESKKSLYTKVLTKNSKNMLILDSDMLTEDLQSTQIYTTQVSAQYKKFQFALENAYFTTTQESGLYLNGKYDDENHIYEGSLLLNFYVLELLPTLPHPYTINRRPGNRLRDQITGNLQAVTKWKTKEGFPEADVTFKLNHQFTDIEENNNSDFGQKILMRGLPQLKNSFMLFDVSTESDHWGVALSMQNRDEMRKIYHDDLNVTGENVVTINRNYLQAPMGFLRGLTLPDVSWEPVNNITPKQEPANPGDLPIPDPNMGILNQVPNTIPTVFSQMDYHQVRIHPYDFMQRFKMNLNSPEQNNQDFESKILFTLPNGKYSVASVHPYKNETMYTKHHLQFIRPDFTHQNQEYKGGIQFRIAALKDPNPEAPPRMEGLTAQLRALQDQPGISILGETVTEIFNNVFTPQKPRGVPLTHIDLSGYGASTFSNWKNPAVKFASISQAKFDLLKGRTAHEIVQAVSVIYPWGICVTRTVTFVRNNNAVIFREDSGWVAQSEGFFDFSFTWPTETETLEFANPYDIFPGLVQGLYNVKNISEDYTDVISGQYTTATGEYYLDESVPIVRESAPGNKVNYEFVAVYFDTDVDLDALDQNTTGRHFKGYLQIKPQGVPVPARILKEILNKSQNPVSGTIDALIPVEKTLQKFKTNAVEMTASYQNDNMSRHAFVASVKGSAILPADGSWSVVDVDKDAGTVQNLKTGTSVGLVKDGLRPKNNGNPFPLSSTKTLLAYPDALKNTAATFNRTYGFLQNTDTQKILLKSIEYTKGETEKYTSEPALLADCFRLMNSKGPFPNLADAIQIDDEIKTTMNLLENGVEKAFNLTVPNDFKFDIVGTENDPFRIYVKYTAIDADGSDTNESLISYVTDSGSAEKWANKMHNITIAVDLAGFQPLMYISGNFSNEKTKNPGMAIGTGPQLKLDKMLQTIYDILEFLNNLDPTQPSEAIKKALKIAMSNSADSWEYKFKADKEIPLVKFPFDPINYNSPTTPLKMDAFFRVGVYFNQPITIPKTIDQIKPSVGAYLELGADIRVMCVSVAAATIYAIGRAEVGLAADLSSPPALYFKLGFGIELTVGLPVIGSVAVTFMVGIDMKISGDIIVGAFIYFRGRAEILGGIVTITISIEAAGQVQKKVGSGPTNCIARCTFALDISIAFVVNISFTETWEETRQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q0</accession>
    <name>C6X2Q0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
            <ecNumber evidence="3">1.1.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:14833"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; (R)-mevalonate degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.88" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806997.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02280"/>
    <dbReference type="EnsemblBacteria" id="ACU08713">
        <property type="protein sequence ID" value="ACU08713"/>
        <property type="gene ID" value="FIC_02280"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02280"/>
    <dbReference type="eggNOG" id="COG1257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033422_0_0_10"/>
    <dbReference type="OMA" id="GHMKMHL"/>
    <dbReference type="OrthoDB" id="617929at2"/>
    <dbReference type="UniPathway" id="UPA00257">
        <property type="reaction ID" value="UER00367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140643">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="442" mass="49544" checksum="B3C524101501FB1C" modified="2009-09-22" version="1">MDHQPVEGFSKLSKQGKIDWIVNEYLDGNRGYEEVLKQYWNDKPELQKLHEEFSENTISNFYMPYGIAPNFLIDGKLLALPMAVEESSVVAAASKAAKFWIDKGGFKTTIINTKKLGHTHFILNVEPHKLQHFFNFKLKKKLFEATEDITKNMRNRGGGILNIRLVDKTADLENYFQLKASFDTVDSMGANFINSCLEQFGKTLKEEVAKEDDFTQEEKDSLQIVMNILSNYTPDCIVRAEVSCKIEDLKDDSGISNEEFATKFKRAVTIAEIEPFRATTHNKGIMNGVDAVVIATGNDFRATAACAHAYAAKSGSYSSLTHCTIDNGIFRFWIDLPISVGVVGGLTNLHPLVKFSMALLGKPSAQELMSILAVSGLAQNFAALRSLVTTGIQKGHMKMHLLNILNQLGATEDEKNHFVTYFKDKTVTHHEVINEFNTLRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V2</accession>
    <name>C6X2V2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02332"/>
    <dbReference type="CAZy" id="GT8">
        <property type="family name" value="Glycosyltransferase Family 8"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08765">
        <property type="protein sequence ID" value="ACU08765"/>
        <property type="gene ID" value="FIC_02332"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02332"/>
    <dbReference type="eggNOG" id="COG1442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050833_0_1_10"/>
    <dbReference type="OMA" id="TVFLHFC"/>
    <dbReference type="OrthoDB" id="842233at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="315" mass="37164" checksum="68B676667B2A61B0" modified="2009-09-22" version="1">MQQPRMNLLPIVFTCDDHYFKYAAVVISSIIHNSSRNTKYEINIVSEYISDENQSLAQKMVQSKSNISIQFHAIKIENPEVFHLNSYMSLSTYYRFFIFDLLKDYDRVLYLDSDLIVDNDISFFADIDFENKPAICCPSIYVQNSLKNNTDHKFTREYFTQILKMSDVDEYFNAGVILFNIKLIRAQGIDRKFFEAIKNIKDPVYQDQDILNSVLRNNGGAKLISNEYNHTKTMKFSLKRIFLNALKNKFGKKRNNWFTIYHYVGKVKPWQNFNPDSALFLYYAYKTPFVREILKSNRLKLSSSLKIQLMVLSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X6</accession>
    <name>C6X2X6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02356"/>
    <dbReference type="EnsemblBacteria" id="ACU08789">
        <property type="protein sequence ID" value="ACU08789"/>
        <property type="gene ID" value="FIC_02356"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02356"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_0_10"/>
    <dbReference type="OMA" id="TPDDMRG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="414" mass="45515" checksum="587487AFFC1F3847" modified="2009-09-22" version="1">MHMISLQPFQTLKIPEFRNLMTGRFFLVLSFRMLATLMGWWIYQLTKDPFAIGLIGLSEVIPAVSTALYAGHVIDNSEKKKLLLICNYAYVLLIALLIIPAFFGHKLLHLSNLQISYFIYAVIFFTGFCRAFLGPIIPSMIPKIVSRETLPNAITINQGTFLTASVCGHALGGFLIHWIDISGTILVVVALMILSSFFFWGLKKHPSENTEREIGVVQSMREGIAYIYKTKEILGALCLDMFAVLFGGAVAMIPVFASDILKVGSEGFGMLNAASDIGSMCVIAFLAFVPLKKNQGKILLFAVAGFGLCIIGFGFSKWYWLSFGFLMLSGMLDGISVVIRGTIVQLKTPDHLRGRVLSVNSIFIMSSNEMGQFESGVAAKLLGVVRSVIFGGTMTLLIALIVGSTNPKLRKMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X321</accession>
    <name>C6X321_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor SUI1-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807118.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02401"/>
    <dbReference type="EnsemblBacteria" id="ACU08834">
        <property type="protein sequence ID" value="ACU08834"/>
        <property type="gene ID" value="FIC_02401"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02401"/>
    <dbReference type="eggNOG" id="COG0023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_4_1_10"/>
    <dbReference type="OMA" id="IIIQGDY"/>
    <dbReference type="OrthoDB" id="1752091at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="109" mass="12247" checksum="DE215C842ACAAAEB" modified="2009-09-22" version="1">MDLRDQLKNFFPAHEEQDFELVEEQEVFVQKEPLVCKFEKKGRHGKPVTLIEGFEGSEAELKNISKKIKTTLGIGGSAKDGVIVIQGDNRDKIMKILQDAGYKTKRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X334</accession>
    <name>C6X334_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02414"/>
    <dbReference type="EnsemblBacteria" id="ACU08847">
        <property type="protein sequence ID" value="ACU08847"/>
        <property type="gene ID" value="FIC_02414"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02414"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088548_0_0_10"/>
    <dbReference type="OMA" id="YMPNMYE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="256" mass="26489" checksum="25D9229A273C064B" modified="2009-09-22" version="1">MTKNIFRITAIVGFAAFSLSSCSKETPPLVYFPDMYYPVAYDPLMKAELAYDDRENEIPAFVKNGGATGLRPVDGTVAQNTDGITDAAGNSGMSIDNYNAGYDASKQDNVSPLNAANQKKDIERGKVLYNQTCAACHGTGGDGQGPVVASGAYAGVPAYKDRELTVASVKYVIKHGRNAMGSYAGQLKPGDQWRVAMYVMSEFKGGVSPAASATPGSTTSVPGAAAALTETPAPAAGTPPVSTQGNAGNVSTSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X343</accession>
    <name>C6X343_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807140.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02423"/>
    <dbReference type="EnsemblBacteria" id="ACU08856">
        <property type="protein sequence ID" value="ACU08856"/>
        <property type="gene ID" value="FIC_02423"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02423"/>
    <dbReference type="eggNOG" id="ENOG503006P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2070122_0_0_10"/>
    <dbReference type="OMA" id="LMHIAIC"/>
    <dbReference type="OrthoDB" id="1815609at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="128" mass="14888" checksum="5165514249CEFB78" modified="2009-09-22" version="1">MENKTDGQLWEMVEAFFVKTFDTDKHPQIDTILFLIGVQELGSGQQKYTKDDKLNILHIAVCRLLEPFGYYKFSHYDDDGYPHFDEVEKLPELKPNEQQILMKKAIIQYFIDENLFDEAAPPADSDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D3</accession>
    <name>C6X3D3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ordered locus">FIC_02516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02516"/>
    <dbReference type="EnsemblBacteria" id="ACU08946">
        <property type="protein sequence ID" value="ACU08946"/>
        <property type="gene ID" value="FIC_02516"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02516"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_0_10"/>
    <dbReference type="OMA" id="GYCAFVV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="47"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="25589" checksum="B56F8041379557C8" modified="2009-09-22" version="1">MIENRYQFMNKILVFLMSLILYSCNGQEPKKPITKNVKMDKQNLEYITFGGGCFWCVESCFNMLKGVDAAISGYSGGHKTNPTYEEVCTGETGHAEVVEIAYDPKIISYEQLMDVFFFLHDPTQLNRQGNDIGTQYRSVIFYKDEAEEAKAEAALQASAASGRWNGKYVTELAKFEKFWPAEQYHQGYYNENPNQPYCSAVVGPKIAKFKKHYGELGMLEPKTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I4</accession>
    <name>C6X3I4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">surE</name>
        <name evidence="7" type="ordered locus">FIC_02567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807281.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02567"/>
    <dbReference type="EnsemblBacteria" id="ACU08997">
        <property type="protein sequence ID" value="ACU08997"/>
        <property type="gene ID" value="FIC_02567"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02567"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_0_10"/>
    <dbReference type="OMA" id="DCVHIAL"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="255" mass="27985" checksum="0A10375DE0784018" modified="2009-09-22" version="1">MQRPLILVTNDDGITAPGIRNLVEFMNEMGDVTVVAPNSPQSGKGHAITINSTLTFEEINLEGPQKDYSLSGTPVDCVKFALDKILPRRPDLVVSGINHGANSSINVIYSGTMSAAVEAGVEGLPAIGFSLLDFSWDADFTQAKKHIQAIVKKVLENPMPKGVVLNVNIPKLKTEEIKGIRVCKQADAKWEESFDQRVNPHGKTYFWLSGYFNNMDTSPDADEVALAEGYISVVPVKFDLTAHEYMDELSEVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L3</accession>
    <name>C6X3L3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SusE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782148.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00543"/>
    <dbReference type="EnsemblBacteria" id="ACU07001">
        <property type="protein sequence ID" value="ACU07001"/>
        <property type="gene ID" value="FIC_00543"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00543"/>
    <dbReference type="eggNOG" id="ENOG502Z9A6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042892_0_0_10"/>
    <dbReference type="OMA" id="TPNGWDG"/>
    <dbReference type="OrthoDB" id="1184718at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025970">
        <property type="entry name" value="SusE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032187">
        <property type="entry name" value="SusF/SusE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14292">
        <property type="entry name" value="SusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16411">
        <property type="entry name" value="SusF_SusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SusE" evidence="1">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="363" mass="38832" checksum="D1C35FF0C7FED293" modified="2009-09-22" version="1">MKNNIFKHLFLAMAVMVGLASCEDRDIITINPEAPAILMDLSTESLVLDSNFPANPALTVTWDPATFDVPVETKYRVEISATEKFDVAEVLASTTRSQTYVSFTTAEMNTAAKKIGFVPGTSQKMFLRVISFIGTDALMDVSNVTSLMITPYAAAPIYNYTDLFLVGDATAAGWDNLVTNGNLLPLLKSTEAGTYSFTGFFKAGGFKMIAVKGSWDAQYGLGSASGMLSSDGGSGNIPVAADGYYTLTIDTAGLTYTLAPATVPAATYANVSIIGNVNGNWDTDTQLTQSTFDPHVWTAFSVSLNAGEFKFRANNAWDVSWGTNAEFFGTAVAGGANIPLSAEWVYDIYFNDATGAYTLIPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P6</accession>
    <name>C6X3P6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="3">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782181.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00579"/>
    <dbReference type="EnsemblBacteria" id="ACU07034">
        <property type="protein sequence ID" value="ACU07034"/>
        <property type="gene ID" value="FIC_00579"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00579"/>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049290_2_0_10"/>
    <dbReference type="OMA" id="DIKPTRV"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973427" evidence="1">
        <location>
            <begin position="26"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="342" mass="38412" checksum="3CDC2EFAE454E9F9" modified="2009-09-22" version="1">MRKPLYVIGLSVLLASCASTKPATKNTTKPKPTAVKGVEAPKTQAPVAARTQLKQEGEYDFFKVNIADVTKNDNTISYGSIVSANPQGYRVVKTFFPAVAQNFRQKYIILHYTALDDDKSVMVLTQQSVSSHYLVNNLGDREIYQLVDENKRSYHAGISTWRNDSMLNDTSIGIEIVNAGYVTDSTGVKIFPGFDEGQVKKVAALVKDIAGRYMIPPTNILAHSDIAPTRKQDPGPKFPWKKLYDEYQIGMWYDESAKQNFLNQLTPEQFSAQAAESDFIYRYQLALKNLGYGLEASGRIDDSTKKTIEAFQYHFRPEIYNGVMDAESWAILQALNQKYPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P9</accession>
    <name>C6X3P9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782184.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00582"/>
    <dbReference type="EnsemblBacteria" id="ACU07037">
        <property type="protein sequence ID" value="ACU07037"/>
        <property type="gene ID" value="FIC_00582"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00582"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563564_0_0_10"/>
    <dbReference type="OMA" id="FMFNIAP"/>
    <dbReference type="OrthoDB" id="483605at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973535" evidence="1">
        <location>
            <begin position="21"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="480" mass="54323" checksum="6C0F1EE7D9B827EB" modified="2009-09-22" version="1">MLPARHICFLALLIASLAFGQVNITISNDRFSGINSAVISPTQPFMNPNPWDINLAAEHAFLENDYLYISKQSLLGLKNAEIESARPRQNISGENTANVLDFYNRDFGNYHLSSEVLGPSFSVAATVMEKSFVVGLFTRLRTQSAALDVDNYLKFSNQRLTEPELYTLQPLEFNVMNWAELGFNFSTELFPYSDYQWIIGGNIKYEVGLDAAMVRSTSPLQLVRTSETIDGTTSKTITAYNFNLETSFVTNYNFETSSYELKPQGKGLGIDFGIAVLDNREEIADYRFKAAINILDVGKINFSGENHRFNGQQLVVVNNPNIENTRLESPQKIMRLLSEEVYGDENASFQGTDFSIGLPTSVHVNFSWGLGSDRFIHTDWIQRVPVFENSLRRSNLFSASYSVQKPALGYGVSASLYEYRAFHVGGYLRIGPLILGSQNVFPLFMKQKKLHSADFYVALKLYPFWDTEFKRHRRADCYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S7</accession>
    <name>C6X3S7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00610"/>
    <dbReference type="EnsemblBacteria" id="ACU07065">
        <property type="protein sequence ID" value="ACU07065"/>
        <property type="gene ID" value="FIC_00610"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00610"/>
    <dbReference type="HOGENOM" id="CLU_1114508_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="249" mass="28723" checksum="B1E3255F93B9FF0B" modified="2009-09-22" version="1">MLTGVLQWWGETAKFNGISSIELLYKIEDLCFDCPTIAKPRNVICNTFTTIRMNIKTIFFYLLIGTILSCKGQKSDKSIKIVDKNTGFQMNLPKGFEELTENESSKILSDGKKNIDQIYDTDVEISDIKPKLFKFDDNNYFLINIREYDPKIDGDYSKAVNESNGLLYRTYIRSFENAKVDSLNEQKRIDNINFTKYSLFVNIPPKTKMKVINYTSFVKNRDLTIALVFKDENLGSEVINAIETAKFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T1</accession>
    <name>C6X3T1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07069">
        <property type="protein sequence ID" value="ACU07069"/>
        <property type="gene ID" value="FIC_00614"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00614"/>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784960_0_0_10"/>
    <dbReference type="OrthoDB" id="1897185at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="392" mass="44404" checksum="F7FE667047FC0F31" modified="2009-09-22" version="1">MMISLVVHVVIFTKTSYHNPRQQKYPTVTCKHRQHNHERKTMRDDFTLETKIQLAKRVSYHCSFPGCGSLTVGPSDESEKSTSSVGTACHISAASEGKGARRYDANLSPEERKHISNGIWMCDKHGKLIDTDETRFSTELLKTWKELAENVASFMVQKGYDYQTALKLLEGKKLANNDVTIEQTGTENEKIGNLITDSCISIVWGKQISDAIRDYLIEHFRNSFGHGNATSFEIIINENKITISDNGTEFNPQQLIENEEKTGGTIAIKNLLLQHSDKLIFTTQRNGDSNRTIITILDNADAIFSITPCSVQLTFEEFHYGNSTITISKDCNEFYIVLPPYFALSDVRFMPKKFPQFDRTGKSLVFIVEHISDGVQTLLRENYPECRIIGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T9</accession>
    <name>C6X3T9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782224.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07077">
        <property type="protein sequence ID" value="ACU07077"/>
        <property type="gene ID" value="FIC_00622"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00622"/>
    <dbReference type="eggNOG" id="ENOG50332MR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1341589_0_0_10"/>
    <dbReference type="OMA" id="NHIKFRI"/>
    <dbReference type="OrthoDB" id="1248566at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025412">
        <property type="entry name" value="DUF4304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14137">
        <property type="entry name" value="DUF4304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="204" mass="24372" checksum="7310A696307AADDC" modified="2009-09-22" version="1">MKTVSETKFDKIIKNGFHEVLKPLGFKKKENNFYLKLDRIGQIINVQKSVWGNKNNIDFTINTGIFVPEYWLAFYDFINKGLPDYPTEPECLIRKRIGTIRNQHDTWYHIKETTDEEQLIVEMRKNLTEFILPYFDRLNSTEKMLQELEKADMMMTPLGKLIVYGELNQFDKAKREYEILLNNKTNPHFLMTVKEYGQKYKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W1</accession>
    <name>C6X3W1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Protein translocase subunit SecD</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Protein-export membrane protein SecF</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">secF</name>
        <name evidence="9" type="synonym">secD</name>
        <name evidence="11" type="ordered locus">FIC_00644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782245.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00644"/>
    <dbReference type="EnsemblBacteria" id="ACU07099">
        <property type="protein sequence ID" value="ACU07099"/>
        <property type="gene ID" value="FIC_00644"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00644"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_3_0_10"/>
    <dbReference type="OMA" id="TAQLEFW"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="896"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="971" mass="106938" checksum="ECD4D9B5C32DB999" modified="2009-09-22" version="1">MQGKGLITLVAVILGLICLNELLPTWYASKIEKQATELAGGNPEKYQKEMARLSKDTLNLGFTKLYYSKSKEKEMKLGLDLKGGINVLLEINQRDLVNNLTNYSTNPVLIEALDRTDQLQKNSTNPYIKDFFTMFDVVNKEKNANLKLADPEIFGNTNLSEIKFNTPDEQVKNIIENRIELSTGTAYEVIRTRIDKMGVTQPNVQRVPRTGRISVEMPGVKDIDRVKKMLQTSAKLQFWEVQQVQEILPYFEQLNSVIGAKADSIGVPGNTNLVSLLQLNTLKSNGVANVKLSDTAAVNKILKSQTAKDLRPQNIKYTQFMWGYKPELSDPNNLVLYAVRGNINQKAPVDGAVESARVNYDDLGRIVVDMQMDSKGSKDWKTLTGKNVNKPVAVTLDEVVYTAPNVVNEIPNGRTQISGSFSQEEAQDLVNVLGAGKLPAGAKIVQAEVVGPSLGAESVDAGMYSFIIAFVIIILYMLFYYGGAGVYAVIAISINLFYLMGIMDSVDATLTLPGIAGIVLSMAMSIDANVIVYERTKEELFAGKNIREAYNEGFKFSLSAIIDGNITSLLTAVVLYIFGTGPIQGFAVTLGIGIILSMFTCVLLTRVLIFSRLEKGKGLSVWTKFSKNIFRNTWVDFIGKRKYAYIFSGIVTLICLASIFTQGFKYGVDFKGGRSYVVRFANPVVADQAAESLEKQFINSEGQVNAVDVKTYGSNNQLKITTDYRVDEESLEADQDVESKLFAGLKQYLPADAKMSEFKDSGANNYGVISSVKVGPTVADDIKSGGVIAMFVALAGIFLYILFRFKRWQFSTGAIASLVHDAIVILGVYSLLKNVMPFNMEINQDFIAAILTVLGYSINDTVIIFDRIREYLGEKKSLTLEGLFNDSISSTLGRTFNTAFMTFLVILAIFIFGGENLRGFMFALLIGVGFGTYSTWFIASAVSYDLLKKKGVEGTKKSLIAEKPVVADTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X422</accession>
    <name>C6X422_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxH</name>
        <name evidence="10" type="ordered locus">FIC_00705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782306.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00705"/>
    <dbReference type="EnsemblBacteria" id="ACU07160">
        <property type="protein sequence ID" value="ACU07160"/>
        <property type="gene ID" value="FIC_00705"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00705"/>
    <dbReference type="eggNOG" id="COG0259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_2_10"/>
    <dbReference type="OMA" id="PEPNAMV"/>
    <dbReference type="OrthoDB" id="1542844at2"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="8">
        <location>
            <begin position="44"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="9">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="214" mass="25234" checksum="D1BB9B1F2630F99E" modified="2009-09-22" version="1">MENLHDKRKNYEKSELLEHQIKENPMEQFRNWYLEAQDNPGIYEANAMAVSTLEADGCPRTRMVLLKSYTWEGFVFYTNYESRKGRAIETNPKACLHFFWPNMERQIIIKANLVKIAANLSDGYFDSRPKGSQLGAVVSPQSQIIPDRNYLEDKLKVLEREFDGKEVPRPDNWGGYIAKPYEIEFWQGRPNRLHDRILYELQPDFDWKISRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X427</accession>
    <name>C6X427_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00710"/>
    <dbReference type="EnsemblBacteria" id="ACU07165">
        <property type="protein sequence ID" value="ACU07165"/>
        <property type="gene ID" value="FIC_00710"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00710"/>
    <dbReference type="HOGENOM" id="CLU_3365099_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="4090" checksum="F271285EBC5A90F7" modified="2009-09-22" version="1">MLADKQHNEHQNRDNGGQNFKEGFHGVVVLHKYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X429</accession>
    <name>C6X429_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782313.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00712"/>
    <dbReference type="EnsemblBacteria" id="ACU07167">
        <property type="protein sequence ID" value="ACU07167"/>
        <property type="gene ID" value="FIC_00712"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00712"/>
    <dbReference type="eggNOG" id="ENOG5032SW8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1764660_0_0_10"/>
    <dbReference type="OMA" id="TIWTGGH"/>
    <dbReference type="OrthoDB" id="1736268at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="16480" checksum="6B90CBCA408C39E2" modified="2009-09-22" version="1">MSHHFLLILHLLGSAVWVGGHLVLAFGILPEVIKKKDPEILLNFERKYEKIGIPALVIMVVSGVWMAYQFGIGMSRWFHFADPVESVVSIKLLLLFCTVLFALSANIFVLPKLSPAKLPLMAFHIISVTALGIAMLVLGSFVRYGGIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X490</accession>
    <name>C6X490_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative two component system histidine kinase/response regulator fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782374.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00775"/>
    <dbReference type="EnsemblBacteria" id="ACU07228">
        <property type="protein sequence ID" value="ACU07228"/>
        <property type="gene ID" value="FIC_00775"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00775"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136468_0_0_10"/>
    <dbReference type="OMA" id="MINETTE"/>
    <dbReference type="OrthoDB" id="1542225at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="244" mass="27560" checksum="8624B32C3199435F" modified="2009-09-22" version="1">MNDLSNDLQSKIESLQNEISFKNGLISILSHDSKSLFGNFVWLIDAVEQKTISEGDFFKMLPQVKSDAQKNLQTVQDSTTWLKTQYGEYKIKPEKIMVMDLFHDLEEKYAAGFKQKNLNFYFKGDADAFVETDRILIDFVLDKILNNAVKYSLPGHDIYFNVCAEEAQVILSVTDSGTGMDEKFLSKIYTYENPVFQGTAGETGVGLSLKIVRNFISLMRGSIRIVSSESTGTNVSLFLPKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X499</accession>
    <name>C6X499_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hemolysin-related protein containing CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_00784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782383.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00784"/>
    <dbReference type="EnsemblBacteria" id="ACU07237">
        <property type="protein sequence ID" value="ACU07237"/>
        <property type="gene ID" value="FIC_00784"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00784"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_10"/>
    <dbReference type="OMA" id="EHTMVRN"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="215"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="424" mass="47979" checksum="04ACCF153E8F3D7E" modified="2009-09-22" version="1">MEIIIIIFLVLLNGIFSMSEMSLVSSRKFKLENAGRNGNSGAKKALELSENPTKFLSTVQIGITLIGILLGVYSGENLTNDFQSVLNGIPTIAPYSKTIATIGIVIFITYLSILLGELLPKRIAMTYPEQIITLVAKPMDLLSKVTSPFVWLLSTSNNLLLKLMGIRMTSDTIVTEEEIKSIIKESAQEGEIDEIEQNIVERVFELGDRKVNTLLTHRTAMSFFDVDDTLPEILNKIRNNKHAAYPVTKGNNLDQVLGIVLLKDLFPLDDPNNFRIDQYLKQPLFLNENNYAYKVLEIFKRERNHYGIVIDEYGNTVGIITLDDVLEALVGDASEEGDFDYRITVRDESSWLADGQVPIVEFLKYFNLNYEFENNDHYTTLVGFFLNEHHGTTTVGDKIQIEDLELEIIDKDGQRVDKILITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B1</accession>
    <name>C6X4B1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782395.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00796"/>
    <dbReference type="EnsemblBacteria" id="ACU07249">
        <property type="protein sequence ID" value="ACU07249"/>
        <property type="gene ID" value="FIC_00796"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00796"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082049_4_2_10"/>
    <dbReference type="OMA" id="NVPIMAK"/>
    <dbReference type="OrthoDB" id="1739979at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973564" description="OMP_b-brl_2 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="22134" checksum="6CBC641EFE4D602F" modified="2009-09-22" version="1">MKKLFVGAAIAMSSLTFAQQFGIKAGMNVSSLSTDSQLSDQGSKIGFNAGLFMNAPLAENFSIQPELLYSQMGDKYDQTIAGTTYARSRHLDYVTLPVMFQYNATPSFYLEAGPEFGLMVNAKNKFTNETDNNTITESGDYKDQLNTFNFGVGLGAGYYFTPQIGLTARYVAGFTDIYNSDNNGSDDSVKNNVFQVGLAYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D7</accession>
    <name>C6X4D7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00822"/>
    <dbReference type="EnsemblBacteria" id="ACU07275">
        <property type="protein sequence ID" value="ACU07275"/>
        <property type="gene ID" value="FIC_00822"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00822"/>
    <dbReference type="HOGENOM" id="CLU_2915762_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="61" mass="6762" checksum="549E14B1492B4806" modified="2009-09-22" version="1">MPASGKLLKNIGRIAEGCSDQNLLGDRLVFRLHVVVCAAFLSFCKSNDYHPVLKFQILNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F2</accession>
    <name>C6X4F2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.117</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00837"/>
    <dbReference type="EnsemblBacteria" id="ACU07290">
        <property type="protein sequence ID" value="ACU07290"/>
        <property type="gene ID" value="FIC_00837"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00837"/>
    <dbReference type="eggNOG" id="COG2171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050859_0_1_10"/>
    <dbReference type="OMA" id="YFPIQKM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.166.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023180">
        <property type="entry name" value="THP_succinylTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037133">
        <property type="entry name" value="THP_succinylTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14805">
        <property type="entry name" value="THDPS_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_N_2" evidence="5">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="269" mass="29325" checksum="6820EB33FE5FA4F0" modified="2009-09-22" version="1">MLQQTIENIWDNRELLQNDDSQASVREVIRLLDLGELRVAEPTENGWKVNEWVKKAVVMYFPIQKMETIEVGPFEFHDKMPLKRNYAEKGVRVVPHAVAREGAYIAPGVILMPSYVNIGAYVDSGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQAAPVIIEDNVFVGSRCIVVEGVHVEKEAVLGANVVLTGSTKIIDVTGDDPVEIKGRVPARSVVIPGSYTKYFPAGEYQVPCALIIGQRKESTDLKTSLNDALRENNVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K0</accession>
    <name>C6X4K0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782484.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00885"/>
    <dbReference type="EnsemblBacteria" id="ACU07338">
        <property type="protein sequence ID" value="ACU07338"/>
        <property type="gene ID" value="FIC_00885"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00885"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_0_0_10"/>
    <dbReference type="OMA" id="VSMRQED"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="153" mass="17422" checksum="CA52732105B73FF1" modified="2009-09-22" version="1">MKALDITDHKILNFLQEDSTVSVKDLAEKIGLSFTATYERIKSLKNNGIIRKNVVLIDPELAGFELMAYCNIVLKEQSHDKLQEFEDKIKAEPQVMEVVSLSGQYDYMIKVVAKNIKDYNSFMTTVIANIPNIGQYHSNIVLSVIKNDTKFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M9</accession>
    <name>C6X4M9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00915"/>
    <dbReference type="EnsemblBacteria" id="ACU07367">
        <property type="protein sequence ID" value="ACU07367"/>
        <property type="gene ID" value="FIC_00915"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00915"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_10"/>
    <dbReference type="OMA" id="FYVMARF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="385" mass="43912" checksum="6C12B567E53430E8" modified="2009-09-22" version="1">MSMVSRKHSGQDLSIFSEMSALAAKHDAVNLSQGFPDYGTDPLLMKLLTEGTERNFNQYAPMAGLPMLLENLVEFNRNREIPLNVDTQNITVAPGASYAIYIALATILKFGDEVIVLQPAYDSYVPSIEMNGGVPRFVSLKENFDVDFEALKNAVTEKTRAIIVNSPHNPSGKVWRKEDWDQLSDIVKDSNIMIISDEVYDILTYDKTPFYSAFHHPGLRERCFSIFSFGKMFHVTGWKVGYVLASDELSRAYGRVHQYVSFCVNAPAQYALAKYLEIFDVQQNRKFMQDKRDFFIESFKGLPLTFTKKSEAGYFQVMKFENEDALNDKAYAVWLTENAKVAAVPVSAFYHDAQNTGLLRFCFAKKEETILSAADYMRRFFETRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S7</accession>
    <name>C6X4S7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xanthosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782561.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00964"/>
    <dbReference type="EnsemblBacteria" id="ACU07415">
        <property type="protein sequence ID" value="ACU07415"/>
        <property type="gene ID" value="FIC_00964"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00964"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_1_2_10"/>
    <dbReference type="OMA" id="FMMMTNG"/>
    <dbReference type="OrthoDB" id="791272at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004740">
        <property type="entry name" value="Nuc_H_symport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03825">
        <property type="entry name" value="Nuc_H_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00889">
        <property type="entry name" value="2A0110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="231"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="440" mass="48947" checksum="9AA8885F49231866" modified="2009-09-22" version="1">MNLKLRLTVLSFLQFFVWGAWLTTLGTYGFSYKQWSGAEFGAVFSTLGIASIFMPALMGIIADKWINAEKLYGTLHILYGLTLFLLAKTDDPTSFFWILLIGMCFYMPTLSLSNSISYKLLKDSHYDVVKVFPPIRVWGTIGFIAAMWCTNIFSDEQSFSNIGIGVGSAVADFFGNSLNANQFYFAGIFAVGLGVFSFFLPKCPPPRLISTDATVSQKLGLDAFKLFKQKKMALFFIFSMFLGAALQLTNMYGDTFLKDFGNVVAYKDSAVVQYSTMIISISQISETLFILAIPFFLYKFGIKKVMLISMAAWVLRFGFFSFGEPQGFGLLLIILSNIIYGMAFDFFNISGSLFVESTTDSKIRSSAQGLFMMMTNGFGAILGSAVSGWLISSFYTGAEGAKMWPEIWFVFAVYALVVAVAFAILFKHKHNPVEMAKLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z8</accession>
    <name>C6X4Z8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07486">
        <property type="protein sequence ID" value="ACU07486"/>
        <property type="gene ID" value="FIC_01036"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01036"/>
    <dbReference type="eggNOG" id="ENOG502Z95V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513703_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="544" mass="63914" checksum="33171D30A28BEBA9" modified="2009-09-22" version="1">MMETKPKISIPLDNEVIRNQISQTLHEFPVLQLHMLKPENTPSAEVFILMKNQKDAETLRARRWISRAATAGVFIHISSHHKAVFQLKLGNPFFQYYADPSTMVWMNDEVDKPLKTHSTKKAFKKKLNVFKEKFYHDHDLLMTEVHKFHAGQMYAAAFQNYLTLFEHHVEYLENLYMGCNFFDSDLHTRLRQLTRFIPQLQKVFVMKNEQTFYLISKMEESVSEAEDGGESDIWSEHYGAVKLAESKLYRMVTDRFSEFSHLVRFKKSSPMINHSANGAKSTESLFEKVLKTVITKLAPEEIYLFHRKEIFSPNPEEKQVIYYLLVIGDGIGNSAIEDIQHSVSDRSNGRTTVVILGHSRLYLQNNLYKHQRMMQQIITAENKVYQSNDFHPPLHWHDAVWDSDWASDMNYRTVKDFVAQYFNLRHHVQQDNHCGLAQLFAQSIMRLLRMYVYAALPFYMPHHLNTFSIWKLCVYADPSMEKIEFLFQKLSADFYKLIDYYLKYSDSIARSSSEELVIMDEILNTLTEKIDHLVKEKKLIVKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X537</accession>
    <name>C6X537_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrichrome iron receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805810.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01075"/>
    <dbReference type="EnsemblBacteria" id="ACU07525">
        <property type="protein sequence ID" value="ACU07525"/>
        <property type="gene ID" value="FIC_01075"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01075"/>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_10"/>
    <dbReference type="OMA" id="HEDEDYW"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015891">
        <property type="term" value="P:siderophore transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973702" evidence="1">
        <location>
            <begin position="20"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="58"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="712" mass="78456" checksum="35D8FCEF6570B7EA" modified="2009-09-22" version="1">MRRKLLPVALIMGVTTFHAQSADTLKTEDITEVIINQTKKYKNENAFAVSKLPLKDIENPQVYNSIPKAVLKDQVSTNFKSVLTNATGITRLWESTSRGGDGAEYYTMRGFSTQSRLVNGMASFNNGGLDPANIENIDVIKGPAGTLYGGSLVSYGGLVNIQTKKPYDHLGGEVNYITGTNDLHRLTLDVNAPASEKLSLRLNTALHSEHSFQDRGFNRSFFLAPSLKYAPNERLTFLVNTEFKNNEAANAPMIFLSRYAPLSFSSIDLFEANYLKSYTSSELTTTNPSFSIQGQMIYKISPQWTSQTQVSTSSSKAMGYYQYLWDDSNGDTFTRYLSKSDSKTLASGIQQNFIGDFKIGNMRNRLVVGFDYLNTQVIANDTGWTTLGVVSLVNQTDTGILTKSAADQAVGALDVVPEASAETNIKSAYFSNVLNILPNLSAMVSLRIDNFSGKPNQWAEQEIENQTSFSPKLGVVYQPILNKLSLFANYMNGFQYLAPSQVSLPGSSETQLIIYDPERANQWEVGAKANIIANKLSLTASYYDITVTNKIVANPSSDGALQGGEVFSKGYEFSAVGTPVEGLNLIAGFSRNKSELISGDDTYNGLRPEEAGPEILANFWTNYKVQHGILKDLTAGFGFNYAGEHKTLNRHVIGTFTLPSYTVMNAMVGYFPEKYSIALKLDNLANKRYFSGWSTVTPQRPRTLSLSLGYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X551</accession>
    <name>C6X551_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01089"/>
    <dbReference type="EnsemblBacteria" id="ACU07539">
        <property type="protein sequence ID" value="ACU07539"/>
        <property type="gene ID" value="FIC_01089"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01089"/>
    <dbReference type="HOGENOM" id="CLU_1044891_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="266" mass="30394" checksum="F87F63FCE36E8ECA" modified="2009-09-22" version="1">MYSMLINKKTLYLGVGASIVFGCKETVPQNLDQQSGISDILINGLLLLISFLILGVFVIKIISIRKKRSKRPTNNDNENHNFSSIQNSYADHNAEIVLLNKNLRNLQQELNASKQKYKALEDESLELRKELEATKLQDLQVDSNIITSPLPTVEKVIKDNVIKLKYSKFADEKGVFPHTHLTTSDDGSCYYQLTIDEEKRTGQFEPIISELNMHSFKNNKSMLLFPYCEIVNVLDFWSNINILEPGSLKPSDVEWIVENKCRIELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X562</accession>
    <name>C6X562_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07550">
        <property type="protein sequence ID" value="ACU07550"/>
        <property type="gene ID" value="FIC_01100"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01100"/>
    <dbReference type="HOGENOM" id="CLU_3118084_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="50" mass="5587" checksum="A0D4CAE51F363B9A" modified="2009-09-22" version="1">MQLGEVAEIEAQGLVFHKNSLEERPFSLALSPTFSQTAAVRLTFIMSVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D3</accession>
    <name>C6X5D3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01171"/>
    <dbReference type="EnsemblBacteria" id="ACU07621">
        <property type="protein sequence ID" value="ACU07621"/>
        <property type="gene ID" value="FIC_01171"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01171"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_0_1_10"/>
    <dbReference type="OMA" id="YEVAHVG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="301" mass="34127" checksum="AD1C851681373696" modified="2009-09-22" version="1">MIGIFTSPKPMAPLQIALIVVILKSVHQKLVQMKLKFLTLDKFEPMKIATYNVNGINGRLPVLLRWLNEKQPDIACLQELKAPQDKFPEAAIAEAGYEAVWVGQKSWNGVAVLSKIGTPTVSRTSLPGDESDEASRYLEVKIADLIIACLYLPNGNPAPGPKFDYKMQWFSRLDAHAEMLITSGKKVLLIGDFNVMPTEKDVYKPEKYINDALFHPDVQAAFHNLTEQGWTDAIRYLYPDETIYTFWDYFRNAYQRNAGMRIDHFLLSAEVLPQLKKAGVDTDVRGWEKSSDHGPVWIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5D7</accession>
    <name>C6X5D7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01175"/>
    <dbReference type="EnsemblBacteria" id="ACU07625">
        <property type="protein sequence ID" value="ACU07625"/>
        <property type="gene ID" value="FIC_01175"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01175"/>
    <dbReference type="eggNOG" id="ENOG503412X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1479970_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970694" evidence="1">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="182" mass="20288" checksum="526FFE4A61623AE7" modified="2009-09-22" version="1">MKKLSLIISMLAVFFMTSCRDIVNTVLDALPPFDVPFSTNLAVPFAGVSTTTYTRTPEIPMNINLDAKIKENNPNYSINNLKSVKLNSLKLDWVSSSLDTRLDVIKNARLYVKAPNQPEKLIATAYDNTNPQTITFTVVDEELLNYFRTSQNSLIFEVMAAGPAADQITMSMSSGFKIRVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H2</accession>
    <name>C6X5H2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07660">
        <property type="protein sequence ID" value="ACU07660"/>
        <property type="gene ID" value="FIC_01212"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01212"/>
    <dbReference type="HOGENOM" id="CLU_1358752_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="201" mass="22164" checksum="5E09D5BA14A0C20C" modified="2009-09-22" version="1">MKPWRGGTAKPKLPFWKVHDLNVAVNFAGNKLQVFFQVVGQRSHQDVFVGLTHAAGINPFHIVMVDEGSQHRLYARTPPLGKETCVIGIAPQFFVHFIVQGFVDAVFYLLELRDLAATLRSQRAVTTGALAAAVTLLSVTLAVGQDSFEGQNGMVSAFLGAAVIIFFFTFSFYKFKPFPLGLVLPEVWKCAAFTNTVEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I7</accession>
    <name>C6X5I7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805960.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01227"/>
    <dbReference type="EnsemblBacteria" id="ACU07675">
        <property type="protein sequence ID" value="ACU07675"/>
        <property type="gene ID" value="FIC_01227"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01227"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024631_0_0_10"/>
    <dbReference type="OMA" id="CFRYLLH"/>
    <dbReference type="OrthoDB" id="1137363at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017599">
        <property type="entry name" value="DNA_S_DndD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03185">
        <property type="entry name" value="DNA_S_dndD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="5"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="699" mass="80535" checksum="265F60DAE8065A96" modified="2009-09-22" version="1">MKINRIKFQNFRIYKGENEILFSPNPSKNISIIAGKNGFGKTTFLTSLIWVFYGKMMNEVEDKYKKDIKNAGGYEKFIKTLLNREVKTDFENHVKTNPVFSVEIELKDILIPSIPCKSVVIKRSYDLRTDIEDLKITIDGLENELTKEVGFEVFINDFILPREIAKFFFFDAEKIVSLAEAKSKSELRNLSKAYSEVLGIKKYEDLRKNLETLLSKLRRSGASPVQQTKLFELTEAEAELSGLLEINQDRQANLDREISNHKLNSDAIQEKLIREGNGITLEELQKMKSEKDQLKLESAEIKSKLKKLMDIAPLVIAGKKLLQLKNQLVFEQVANNNSADKTMLFAELTSFSSLLLKKLESLNLDHTAKSQVEKALEQVISEKKSGNIRGNTDKVLLDYTAEQYRNFEAVYNNIKGAFSSQFNAVVQEEKNNRIYASKVYQQIRQAEARKDNPLAQKLREEKIETDEKINALTISKGKLLEEHERLTTQLSSVRKVLSEFEKNFKLVKTDQKKFEVTEKLLVKINTIIQKIKEDKKFALQKSIMLGLKKIMHKDDFIYNVRVNVLDDVMDIDLLGKNDEIIDKDSLSKGEQQLYATALLKALVDVSGIKFPVFIDSPLQKFDKYHSKNIIKEFYPAISEQVVLFPLLEKELSELEYEYLKPNVNKVFVIENYNNGSSFKPYVVDQLFTHLKQEQDVYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L8</accession>
    <name>C6X5L8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805991.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01258"/>
    <dbReference type="EnsemblBacteria" id="ACU07706">
        <property type="protein sequence ID" value="ACU07706"/>
        <property type="gene ID" value="FIC_01258"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01258"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495838_0_0_10"/>
    <dbReference type="OMA" id="DICMERG"/>
    <dbReference type="OrthoDB" id="405111at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973619" evidence="3">
        <location>
            <begin position="27"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="552" mass="63545" checksum="85090FF99FB8547A" modified="2009-09-22" version="1">MKRCKIITSVIFLFLFLFSPFQHLSAATLQDCDRMIVEGVKAMSERRHSQSLEILMKTQALAAEKRWYRQEFLALNNIGANYYAMLDYGEALNKYLDAYKIALMHLDYKSEMTVLNNIAILYSEEKKFKKSEEYFLKAFDLAQKGKDSTKMGIYAINIATVANETGQTQKSTDYLKIALSVVKIKELLLQTRVVQAENLMLRKQFAEARKLALSLLPESSGVEHKDNRVGLFLILARVDSADEDWSAAINWCRKALAENAGLTKKEVIFEQMSTIYAQKNDFKSALQYKDSVLAVHDSVNTVKNGKLFENSRIKFELQHSEKGLADSLSKLKSERTIFIISTGFILMVIVSLILFFRSKNLRMKQEKVIEENTKKIIKLELEQEKKDREILEKQYEENKVRSLLEEEKLKNEVEAKNRKLTVKVLQLASKNELIEGVISSLMQQSDTENSSAINAAVNQLKHGLREENEQTDFLLHFEEVNRGFLLRLQEKHPDLSANDIRFLSYVYMNLSSKEISALLNITLEACRKRKERIARKMNLAKDADLYTYLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5N2</accession>
    <name>C6X5N2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07720">
        <property type="protein sequence ID" value="ACU07720"/>
        <property type="gene ID" value="FIC_01272"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01272"/>
    <dbReference type="HOGENOM" id="CLU_3403661_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="30" mass="3745" checksum="6A2339B9010C4847" modified="2009-09-22" version="1">MNEVFFCALFYREIFLHDKIMPKFKKLFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5N9</accession>
    <name>C6X5N9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Omp85 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01279"/>
    <dbReference type="EnsemblBacteria" id="ACU07727">
        <property type="protein sequence ID" value="ACU07727"/>
        <property type="gene ID" value="FIC_01279"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01279"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010929_0_0_10"/>
    <dbReference type="OMA" id="GFKTYNP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Omp85" evidence="2">
        <location>
            <begin position="416"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="853" mass="97997" checksum="9C67C3DAC284A381" modified="2009-09-22" version="1">MSGKHLSKYFQKYHIFFALAITALVLYACSTTKKVPDGEYLLTKNTFRYEDGKLLDDDVPNYVSQKPNKKQLFLFPVGLWMYNATNPKYDSILNEYLTYPSEMRDQKLRDSLFIKYKHPEYVGKSLFYERFMHNIGQPPVILDQGKTETSANSIRKYFVYRGYWDADVKFSHDLDSAAKKAEVNYLITHRDPTKISDYYYNIPDPAVRSIYEEDLSKSLVQGKEILDQSVLEKEVKRINDLMKDRGYYRFNNSNEEIYFTADTLQSRKEVPLTMDIHKDSLDSHYKVTTIGDIKVHYLEKLADTVDTVKDSLLGINFYKLDDQYKTMALWRPIILKKGDRYQQRNLDITKRNFASTNNFSVLKYDEILRKENDSILDISYYLAPLPKYDLRIATDINYSQILNFGVSPSVDLTTRNVFGGAENLTTSVSGIFGSVVNSQSSDKRVLAYEISAQAALNFPRLLLPFKTWKLIPKRFSPTTSIVLGTSIQDNIGLGRIGFNAGLNYYANVNDVVTHRLSLFNTQLSLTRNKERYYDFFPIDEQVRDAVFSDYSPALVADLENGRITSDEFASIILNDTAYQNALSGDRLSLYNEFRQSLINKDRQTQDVLISSVIYNFIYNEIGKKDRPNPFYVNAKVELAGNVFSMFNNRTREDGVITGDSKTIFSIPYSQFVKFDFDVRKYFTFFNDKHTLALRQFVGIGIPYGNSSTMPFVRSYFNGGSNDIRAWRVFGGLGPADSQLDEKIRSYAMDNVKLTTNIEYRVPFTPMFEGAAFVDAGNIWGLKDTGFGDEFKFSKFISQMGVGTGLGVRINVAYITLRLDAAYKVYDPNRPVGDRFVLGETWKPVLNFAFGYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q0</accession>
    <name>C6X5Q0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA modification GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806023.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01290"/>
    <dbReference type="EnsemblBacteria" id="ACU07738">
        <property type="protein sequence ID" value="ACU07738"/>
        <property type="gene ID" value="FIC_01290"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01290"/>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057855_0_0_10"/>
    <dbReference type="OMA" id="WKNNPTE"/>
    <dbReference type="OrthoDB" id="1018664at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973622" evidence="1">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="402" mass="46494" checksum="4A77ADABE0C97869" modified="2009-09-22" version="1">MKKFIFILLCSTSIFSFAQIRFEKAYFINNAGERTEGLIKNADWRNSPTTIEYKLADNDKIYVGSLKDIQLFEIYGQAKYVRSNVKMDQSSSLTKNLSTQRAPEFVDKDVFLKEIAGGDVRLYKYAEPTIIRFYYQVNDGPIEPLIYKPYIFEFNSIAHNNEYKTQLEKILVCPSLSSQRIHKTEYKENSLTELFAAYYECANPDGGEKISAQRKSKFNLHIRPRVNSASLNLENTIAYETENQIGFGFGIEAEFVLPFKKNKWAIIIEPTYQYYKSETTITSILTGVQPQIVSVDYKSVELPLGIRHYMFLNSRSKVFVNVQAVLDFSLDSSAKIGTESYPTRYVLELKSSPNVALGIGYRYDDKYGIEARFFTNRDITKQYPDWMSQYKNVSLIFSYNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R1</accession>
    <name>C6X5R1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806034.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01301"/>
    <dbReference type="EnsemblBacteria" id="ACU07749">
        <property type="protein sequence ID" value="ACU07749"/>
        <property type="gene ID" value="FIC_01301"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01301"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005363_0_0_10"/>
    <dbReference type="OMA" id="YYNREQY"/>
    <dbReference type="OrthoDB" id="332676at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021280">
        <property type="entry name" value="DUF2723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11028">
        <property type="entry name" value="DUF2723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1161" mass="132872" checksum="7D4375D6EEA70F14" modified="2009-09-22" version="1">MKNWSFKQWNTVLGWVVFAIAFLTYLSTIEHNFSFWDTGEYIASAAKLEVTHAPGAALFQLVGAVVAMLAFGNADNYSIVINGMSALFSALTVLFLFWIITHLVRRLLNKDFNEISRHEEISILFAGTIGALCFTFSDTFWFSAVEGEVYSMAVLFIALLLWLITKWENEYHDADNERWIILIFFVTGLSVGVHMMCMLAIPAVCLIYYARNYEFSWKTFLWANVITLFILGIVFKGIFPLIMTLFGKMEIFAVNGIGLPFHSGTIIAFIILIALCFFAVNYAKKSGKSLYQTIALSVVYMIIGFSCWMVIPIRAIANPPMNLNNPDNAIGMLDYYNREQYGDWPTAYGQNYTAFLDANGIQKNEDGSFKTKKTGDVYEKDEKTGTYLKVGDRFNYVYSEDHVGFMPRMFSEDKDVMSNYISMYGAPDFSFNYANEDVADSPEAKQIFEELRAKYENGTIKADDYLQVRPYNLINVQKPSLSQNLDYFFTFQNGYYFVRYLMWNFVGRQNDLEGHMENNRGNWISGIPFIDNALWGDQSKMPAKFKNESTVAFFFLPLILGLIGFFFQLNRDFGRFYAILALFILTSVGIVFYTGVKPFEVRERDYAMVGSFFAFSVWIGLGAAALLWTVQKKVKSDALNIVLGVVLLGIPLMMGFQNYNVHDRSGRSAAYDYAYSTLKSLPKNDILFVYGDNDTYPIWGMQETSGLRDDVKVVNFTLLSTPWNIDQVKRRTYNSMPIPSVLTHEDYRDGTNDQIFLMSPEDWQNVFANLKDQGAPETAFADFRKFLTQDSMTLKEAVNFIKVKSDDKDEILKMLFGEDKYEKFNFLPVSKFILPVNKVNAVESGTIQTKDLSQAVDNITIEYKRSSMFKNNLILLDMLAHNDWKRPINFSSGGIYDPENIFYLGDYLQYDGFSYRLVPIKTPEREDGEMGRVDANALYNTVKNYRWGNFKDLNVHFDETCTQNIVSYRSSASRAAEALALTGQKAKAIEMLDLASREIPVEKYNDPRSLSSMVYGYIVSGQEQKGLKLAEELKKGIFSEYDYYGSLSASEQRFVGRQMRTKPMEYSLVVGAVSDAYNKVGQKDKGYSYLVKSIEPIDKRFNNFVKDLKIMGKEKAYKESEKVQKITPFYTYLFDVMNPYDSTYSQEKETQITNAIIKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R5</accession>
    <name>C6X5R5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806038.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01305"/>
    <dbReference type="EnsemblBacteria" id="ACU07753">
        <property type="protein sequence ID" value="ACU07753"/>
        <property type="gene ID" value="FIC_01305"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01305"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_519657_0_0_10"/>
    <dbReference type="OMA" id="GLIQWQM"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="506" mass="58191" checksum="5F85529DDCE1B96C" modified="2009-09-22" version="1">MQIDIRKLAIEDYEELKATMQKAYPAMSQSIWSKKSIEKLIRIFRDGQICITVDGKIAAVALSLIVQYELYGDDHTYKEITGNYTFNTHSETGNVLYGIEVFVDPEFRKLRLARRLYDVRKELCETLNLKSIMVGGRIPNYHLHSAELSPRAYIQKVRNKELYDPVLSFQLANNFLPVRILKNYLPEDVHSEENAVLLQWNNIYYSKKPNTMQDSVIRLGLVQWQMRHFKTIDAFYEQVEFFVNVMADYKSDFIMFPEFFNTPLLAPFNHLSERESMFKLAELTEEIKNKISEFAIGYNINIIAGSMPLVENGELYNISYLLHRDGKIDEHRKVHITPNEKKFYGMKGGNEIKVIDTDCGKVGLVICYDVEFPELPRILADQGMKILFVPYLTDTQNAYMRVRHCAAARAIENECYVAIAGCVGNLPGVNNMDIQYGQAAVFTPSDFAFPSKAVKGEATPNTETTLIVDVDLNLLKELHHYGAVRTMSDRRTDLYDTVDHNNTEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R6</accession>
    <name>C6X5R6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806039.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01306"/>
    <dbReference type="EnsemblBacteria" id="ACU07754">
        <property type="protein sequence ID" value="ACU07754"/>
        <property type="gene ID" value="FIC_01306"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01306"/>
    <dbReference type="eggNOG" id="COG2377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038782_2_0_10"/>
    <dbReference type="OMA" id="VCSHGHT"/>
    <dbReference type="OrthoDB" id="736294at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="348" mass="38890" checksum="6AEE489DC0DF95A2" modified="2009-09-22" version="1">MKFNAIGLMSGTSLDGLDICFAEFQKTADLWKFEILHAETIPYSNVWEQKLRTAMQLSAEQLLALNSEYGFYLGERVKEFISKHKITEIDLIASHGHTVFHQPEKRFTTQIGDGRAIKLLNDIPVVYDFRSQDVLMGGNGAPLVPIGDELLFAKFDACVNLGGFSNISFKEEGNRIAFDICPVNIVLNRYAELLNKKYDRNGETARSGTVNAEVLKALNSLPFYRNSPPKSLGLEWVRENVFELFDGLKPEDVLAIFTEHAAEQISAVFRKYRLEKVLFTGGGTYNSFLIELISSKCSSETVIPNPQIINFKEALIFSFMGVLRINNETNVLASATGSSRNHSSGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T7</accession>
    <name>C6X5T7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gpmI</name>
        <name evidence="14" type="ordered locus">FIC_01327</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806060.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01327"/>
    <dbReference type="EnsemblBacteria" id="ACU07775">
        <property type="protein sequence ID" value="ACU07775"/>
        <property type="gene ID" value="FIC_01327"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01327"/>
    <dbReference type="eggNOG" id="COG0696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_10"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="OrthoDB" id="338375at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="3"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="82"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="190"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="8 10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU07775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="509" mass="56668" checksum="BA199DF260426640" modified="2009-09-22" version="1">MSKKAILAILDGWGLGTDPTVSAIAQAKTPFIDSCLQNFPNTTLEASGPAVGLPFGQMGNSEVGHMNLGAGRVVYQNLVKLNMAVENATLGKENVITQAFEYAALNNKKVHFIGLLSDGGVHSHINHLKGLLTAAHEYGLKENVFVHAFTDGRDCDPHSGKGFVEELLNHMHETTGKLATVIGRYYAMDRDRRWERVKLAYDLMVRGIGERTRDVLATFDNLYADGITDEFFRPILCMKDGNMPVARIENEDVVFCFNFRTDRGREITEVLSQNDFPEFGMSCLKLYYVTMTNYDKDYKNLKVVFDENVLQDTMGEILERNGKTQIRVAETEKYPHVTFFFSGGREDAFLGERRLLCPSPKDVATYDFKPEMSAYDITEKILPEIENETADFICLNFANTDMVGHTGVFSAAVKAAEVVDECIEKVATAAYEHGYAVFILADHGNSDVMRNADGSPNTQHSTNLVPLIVMDKEQTWNLKPGKLGDIAPSILKLMNIEIPEIMTGEVLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U2</accession>
    <name>C6X5U2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-[acyl-carrier protein] desaturase</fullName>
            <ecNumber evidence="8">1.14.19.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01332"/>
    <dbReference type="EnsemblBacteria" id="ACU07780">
        <property type="protein sequence ID" value="ACU07780"/>
        <property type="gene ID" value="FIC_01332"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01332"/>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034505_0_0_10"/>
    <dbReference type="OMA" id="NRHSMLH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102786">
        <property type="term" value="F:stearoyl-[acp] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="327" mass="38099" checksum="9B6280851C5A2285" modified="2009-09-22" version="1">MDMYNKLVRIEVMRNLGKEVGDFISSYLTPVEKIWQPTDFLPDPSSENFKYDVEELQTYAQEMGYDLFVTLIGDCITEEALPSYESWIMGIDGVEQEERTGWSQWVRSWTAEENRHGDLLNKYLYLCGRVNMREVEITTQYLIQDGFDIGTTMDPYRNFVYTSFQETATNISHRRVGSLAKQTGNTKLSRMCGVIAADEARHAKAYKHFVTRIFELDPSEMMLAFEDMMRKKIVMPAHLMRESGQMAGELWGHFSDAAQRAMVYTGQDYINILSELLVDWKIEHISGLNEKAEKAQEYLMKLPSRLQRITDRISTPDQEYQFKWVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V2</accession>
    <name>C6X5V2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806075.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01342"/>
    <dbReference type="EnsemblBacteria" id="ACU07790">
        <property type="protein sequence ID" value="ACU07790"/>
        <property type="gene ID" value="FIC_01342"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01342"/>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013279_0_0_10"/>
    <dbReference type="OMA" id="FNEIDRY"/>
    <dbReference type="OrthoDB" id="1283891at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="627"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="911" mass="105475" checksum="6FC0D9B9BA01BD85" modified="2009-09-22" version="1">MKFLTKIVSELLSQNADLSQFNIVLPGKRPIVFIKKILREKQYSGFLPNFFTIEDLIGELSGKAKVQGVALWLFAFEVYRTVHPSEDFATFLKWFPTLLKDWDDILKFSESDAAVLEYMFSEERIKNWAENLGDSDETPRRKNLNFWQRMNIFIPLLKQKLQEKNWATSGMIHEAAREKIESFAQNTELNFVFCGFNAFTPVEEKLVKNLLQWDKAQCFFQADEYYMNDERQEAGKFLRNHKTWKEFNDSRPFRWIEKDFEQQKNIKVYEVSGNISQAKVLPEIFADIGSADLSKTAVVLLDENLLPATLDALSSAERLNITMGFPLKNLAFSNAMKRLFYLQKQLAQKDSSYYYNDVLAVLEELPNDESDSKTVAEFKTKIEQRNIIYISKKQLNEYLADLSYLNLFQKASSVSAYLDLLIAYCYELKFGDLDDIAYENISHFEKSFRIIKNQISPYSFPVSMETLEVLINQLVNSETIDFQGEPLEGLQVMGLLETRLLNFENIILLSANEGKLPLGNTQNTYLPFDIRRHFNLHTFLENDSIYAYHYYRLIQESQNVHLLFNALNSGVNTGEKSRFITQMEIEDRHHQITNVIIENAADPILQKPMHIAKTPKVIEILEAWKARISASHLTSYIYNPADFYLNKILNTREADEMEEELSQRSYGNLVHYALQDIYEKFVGKTLTVKDLDLTDQNIVEALDHAIEKLNHQIEFYQNGMNFIHKSIAERVVRGVVEYDRKLVAGGNTLEIIGVEGKFDQAEYFLDEEKKDRVGFYGFIDRIDRLNGTVRIIDFKTAKTKNLSISAPKKAEDEEKLQRLFFREDYKQALQLSIYAYSVLKTNVLPDRSVQCGIWSFAEVNKGVQNLCIFGDYDISEANLTLPMKAVGNVILDILNPENEFVEEAKVSWGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W9</accession>
    <name>C6X5W9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="4" type="ordered locus">FIC_01359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806092.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01359"/>
    <dbReference type="EnsemblBacteria" id="ACU07807">
        <property type="protein sequence ID" value="ACU07807"/>
        <property type="gene ID" value="FIC_01359"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01359"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_8_1_10"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="139" mass="14892" checksum="8FDC9AC3BED791BD" modified="2009-09-22" version="1">MSGKITFTMIKPDAVADGHIGAILGKISEAGFKIKALKLTQLTVADAQKFYAVHSERPFYGELVDFMSSGPIVAAVLEGENAVESFRTLIGATNPAEAAEGTIRKMFARSIGENAVHGSDSDENALIEAQFHFSGREIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X5</accession>
    <name>C6X5X5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyanophycin synthetase</fullName>
            <ecNumber evidence="7">6.3.2.29</ecNumber>
            <ecNumber evidence="6">6.3.2.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cyanophycin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_01365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13277"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.29"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23888"/>
            <dbReference type="Rhea" id="RHEA-COMP:13732"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.30"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.29" evidence="7"/>
    <dbReference type="EC" id="6.3.2.30" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806098.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01365"/>
    <dbReference type="EnsemblBacteria" id="ACU07813">
        <property type="protein sequence ID" value="ACU07813"/>
        <property type="gene ID" value="FIC_01365"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01365"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016806_0_0_10"/>
    <dbReference type="OMA" id="PFMIANA"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071161">
        <property type="term" value="F:cyanophycin synthetase activity (L-arginine-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071160">
        <property type="term" value="F:cyanophycin synthetase activity (L-aspartate-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009059">
        <property type="term" value="P:macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011810">
        <property type="entry name" value="Cya_phycin_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044019">
        <property type="entry name" value="Cyanophycin_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18921">
        <property type="entry name" value="Cyanophycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02068">
        <property type="entry name" value="cya_phycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="221"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="876" mass="97419" checksum="28F13720B0501555" modified="2009-09-22" version="1">MKIEKIQVLRGPNIWSIRRKKLIQMRLDLEELEHLPTNKIDGFRERLEQLLPSLITHRCSEGVEGGFFQRVEMGTWMGHVIEHIALEIQTLAGMETGFGRTRETKTPGVYNVVFSYLEANCGVYAAEQSVELVRYLIDAREYDIEACIQRLKEIREQERLGPSTGSIVEEAVARNIPWIRLGRNSLVQLGYGIHQQRFQATITGKTSSIAVDMACNKELTKKMLDDNAIPVPMGDLVTEPEELERVIRKIGYPIVLKPLDGNHGKGSSINVNDYESALIGLQHAQNYGKKVIVEKYITGFDFRVLVIDHKMVAAARRVPAHVVGDGEKNIQQLIDTENQDSKRGYGHENVLTEILVDKDTNELLEKLNYTLDTVPQRGEVVYLKSTANLSTGGTSIDVTDMVHPENITMCERISKIIGLDVCGVDIMAENLTQPLKESGGAILEVNAAPGFRMHLAPSEGLPRNVAAPVVDMLYPQGKPFRIPIIAVTGTNGKTTTTRLIAHIVKNNGYRVGFTTSDGIYIQNTMLTKGDTTGPISAEFILKDPTVEFAVLETARGGILRSGLGFSSCDIGVLTNIKEDHLGMNDIHNLKDLTKVKRVVLDAVKKGGWSVLNADDEYSMRLMPDLDSKIAIFSLDENNEYIRKFAKEGKITCVYEEGFITIKKGEWKIRVVKAHSVPITMEGKARFMISNVLAATLATYLHGFAIEDIANSLRTLIPSAALTPGRLNIFKFKKFNVLIDFAHNPSGYEAIEDYLKNVDSPKKIGIISGVGDRRDEDIMQCGKIAGRMFDHIIIRNEKHLRGRTEEQINGLVISGIHSSGRDVSYEIIPVEIDALKHAMSLAEENTFITALSDVISNAIDLVQEYQNKEILESGNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X622</accession>
    <name>C6X622_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-binding proteins-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806145.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01412"/>
    <dbReference type="EnsemblBacteria" id="ACU07860">
        <property type="protein sequence ID" value="ACU07860"/>
        <property type="gene ID" value="FIC_01412"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01412"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_2_10"/>
    <dbReference type="OMA" id="WMIASYL"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="196" mass="22803" checksum="4026F6CBF30FA54A" modified="2009-09-22" version="1">MENIDSYLSEILELPREAVNQCSNFYVHKTVAKNEFLLRDGEVCTGTYFVEKGLLRMYSIDKNGKEHIIQFAPEKWLISDRSSLHFNEKSRYYIEAVEESEVLVLGNDFFSGINQQFPGTSGNNDLLLQKHIRNLQNRVNSLLADTAEERYLNFIKMYPDILQRVPQWMVASYLGITPESLSRVRKELARKNFQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X654</accession>
    <name>C6X654_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806177.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01444"/>
    <dbReference type="EnsemblBacteria" id="ACU07892">
        <property type="protein sequence ID" value="ACU07892"/>
        <property type="gene ID" value="FIC_01444"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01444"/>
    <dbReference type="eggNOG" id="ENOG5031D3D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133122_0_0_10"/>
    <dbReference type="OMA" id="GVRVTFK"/>
    <dbReference type="OrthoDB" id="1825972at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032577">
        <property type="entry name" value="DUF4920"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16267">
        <property type="entry name" value="DUF4920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973737" evidence="1">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="18172" checksum="62D9B34325D08037" modified="2009-09-22" version="1">MKKIALVLSLAFSTVLFSQEAAKKTGPPEGSALVGDIYGATVSATAEQTAISPKKLDKKLKTSKKIDKVAVKGKVTDVCDKKGCWLTVETDNNEKFFVKMKDYAFFVPTALKGKNVVLEGSAETKVISVDEQKHYAEDAKKSQAEIDAITRPQEETRFVATGIKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A3</accession>
    <name>C6X6A3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="5">IGPS</shortName>
            <ecNumber evidence="5">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trpC</name>
        <name evidence="7" type="ordered locus">FIC_01494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806226.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01494"/>
    <dbReference type="EnsemblBacteria" id="ACU07941">
        <property type="protein sequence ID" value="ACU07941"/>
        <property type="gene ID" value="FIC_01494"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01494"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_2_0_10"/>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="261" mass="29246" checksum="14845941EB38F22A" modified="2009-09-22" version="1">MTILDQIIKRKKEEIAAAMASVSVSELKDAAFFSRKTLSLKETLTAKSGIITEFKRQSPSKGIINNKADIAQVAHSYEKFGASGISVLTDRDFFGGEMRDIINIREQINIPILRKDFMIDEYQFYEAKSMGADVILLIAACLSVQQVEEFTALSHQLGLEVLLEIHIEDELSHFNNNIDLVGINNRNLKDFKVDLQHSVNLRNLLPKGSLAVAESGISGPEDFEFLKQKGFDGFLMGEYFMKNENPGAAFQEFIAKIHPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D2</accession>
    <name>C6X6D2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806255.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01523"/>
    <dbReference type="EnsemblBacteria" id="ACU07970">
        <property type="protein sequence ID" value="ACU07970"/>
        <property type="gene ID" value="FIC_01523"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01523"/>
    <dbReference type="eggNOG" id="COG5368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023287_1_1_10"/>
    <dbReference type="OMA" id="CLITYVM"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016883">
        <property type="entry name" value="UCP028431"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028431">
        <property type="entry name" value="UCP028431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoamylase-like" evidence="1">
        <location>
            <begin position="210"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="453" mass="51777" checksum="D462532380481049" modified="2009-09-22" version="1">MIRILTYFSFISAFTLSCASVDNQTKQSARLTDEQLMDKVQQQTLKYFWDFAEPNSLMGRERYHEDFYPRNDANVVTTGGSGFGLMTLIVGIERGFIPRKEAVQRLTHIADFLAAADRHHGAWPHWLDGKTGKTVSFGKKDNGGDIVETAFLVEGIIAVREYFKNGNAEEKALAKKMDDLWKGVEWNWYTKGGEKVLYWHWSPINGWEMNHKLQGYDETLVTYILAASSPTYPIDAETFYQGWTRNGTYLTDHTKYGLPLFVKHNGAEEYGGPMFWAHYSYLGLDPTGLSDKMVPDYFGLNRNHALIQYNYSLENPKNYKGYGENYWGFTASYTRNADGSVGYRAHNPKEDNGIITPTAALSSFPYTPKESMKVLRFLYEEKPEFIGSAGPYDATSVHFDNWFTPRYLAIDQGTIAPMIENYRTGLIWKLFMNAPEIKAGLKKLGFKSTKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E0</accession>
    <name>C6X6E0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
            <ecNumber evidence="2">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806263.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01531"/>
    <dbReference type="EnsemblBacteria" id="ACU07978">
        <property type="protein sequence ID" value="ACU07978"/>
        <property type="gene ID" value="FIC_01531"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01531"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_0_1_10"/>
    <dbReference type="OMA" id="MQRPIVT"/>
    <dbReference type="OrthoDB" id="1650947at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="115" mass="13569" checksum="CA97562A84312B13" modified="2009-09-22" version="1">MIKVLHNNACSKSRAILEHLDENNVHFEIIDFIENPLSETELRTVVKKLNTDVKDLIRKNDPLFREKYCDKEYTEDEWIKILLESPSLMQRPILIKGSVAMIGRPIENVRFFIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G0</accession>
    <name>C6X6G0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806283.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01551"/>
    <dbReference type="EnsemblBacteria" id="ACU07998">
        <property type="protein sequence ID" value="ACU07998"/>
        <property type="gene ID" value="FIC_01551"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01551"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_10"/>
    <dbReference type="OMA" id="NARENCM"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="13560" checksum="DC873D095F40B323" modified="2009-09-22" version="1">MNSKKIIIVDDDTAILDSLSVMLDYEGFDVNAFQRGTEIFPFVESVSKPDLILLDIWLSGEDGRDICKKLKENEFTKNIPVVMMSAGRDLEKAAYNSGATAFISKPFEIEEVVDTLYQLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H8</accession>
    <name>C6X6H8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806301.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08016">
        <property type="protein sequence ID" value="ACU08016"/>
        <property type="gene ID" value="FIC_01569"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01569"/>
    <dbReference type="eggNOG" id="ENOG5033RJS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721113_0_0_10"/>
    <dbReference type="OrthoDB" id="1316013at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="383" mass="42573" checksum="895BF0A90F2E5523" modified="2009-09-22" version="1">MKNLFLIIFFATAAISCEKGSIQQTTDNLKRADSLFTKANDGIKTLDSISKTISDSNGIAKKVILPEIQKQKKSIDSTIKSGGWRIDSINKQIEKITKNVVVGTEVVKALDSANNALQSGENALKVLTRTADKILNQTKKQNPTTENSTQNNSVTPQEPTAPVVVPPAVVRDPLVKTATLEIQVDDLNSAKALLKQRIRENNADFVSENFSQNEGIEREYITVKVPLQNFDGLVNDLTNGLGDVKVKNTESEGKDYIASQMCDIQITLLQNENIAQNQFGKDNTETGENSFSSAFLKGFEVLKKGLLFLLPFWPIFLIAAGIWYFANRNKRKKAQQEFERQQILSQQNNAPYPVENQTSTAEAPIEKTTDPDEPDYSKYLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB6</accession>
    <name>C6WZB6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ordered locus">FIC_00526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782131.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00526"/>
    <dbReference type="EnsemblBacteria" id="ACU06984">
        <property type="protein sequence ID" value="ACU06984"/>
        <property type="gene ID" value="FIC_00526"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00526"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_3_1_10"/>
    <dbReference type="OMA" id="FKNFIMK"/>
    <dbReference type="OrthoDB" id="1863650at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU06984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="127" mass="13683" checksum="240BCAF16E2FF02D" modified="2009-09-22" version="1">MKLFQEFRAFAFKGNVIDLAVGVIIGAAFGKIVSSLVEDVITPLLLNPALDAVGAKNIAQLSWHGVTYGNFLSAVISFLCIALVLFWLIKAANKVVTPAEAAAPTITKEQELLTEIRDLLKAKQSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC1</accession>
    <name>C6WZC1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00497"/>
    <dbReference type="EnsemblBacteria" id="ACU06955">
        <property type="protein sequence ID" value="ACU06955"/>
        <property type="gene ID" value="FIC_00497"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00497"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_4_1_10"/>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="257" mass="29666" checksum="066C959B1B087FB6" modified="2009-09-22" version="1">MNFQTFRYQLLHDMILRKVLPQNLFDMKLFYGEIFPEVKINEEEQQHILKVLRMRDGEEISVTDGKGNLATGKLITEGKKVSLNVSETHQNLPNFSTQLHIAIAPTKNIDRIEFFLEKATEMAVSEVTILQTEKTERKNLNIDKLRKQSVSASKQSLRYHFPKVNDITKFSDFIKNLDPETTFVAHCNESLERFNLKDIQPQKHTTFLIGPEGDFSEKEINMLADKGIKAVSLGNQRLRTETAGIFVAAWNYQKMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC8</accession>
    <name>C6WZC8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00504"/>
    <dbReference type="EnsemblBacteria" id="ACU06962">
        <property type="protein sequence ID" value="ACU06962"/>
        <property type="gene ID" value="FIC_00504"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00504"/>
    <dbReference type="eggNOG" id="COG5483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077467_0_1_10"/>
    <dbReference type="OMA" id="RHNPQFN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014519">
        <property type="entry name" value="UCP024492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024492">
        <property type="entry name" value="UCP024492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="191" mass="21896" checksum="FA016072073DC3CF" modified="2009-09-22" version="1">MLIFELNHFSMATPKNIIYTIGHSTRSLEEFLVLLRSFDIKVLADIRRLPGSRKFPHFDQGELKKSLAENGIEYIYIEDLGGRRRPAANSKNTAWRNKSFQAYADYMETETFKNAAELLKTYALQNPTAMMCSEAVWWRCHRAMVSDYLKAQGWTVLHIMSEAKATEHPYTTTAKIQGNTVSYEADDQAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF6</accession>
    <name>C6WZF6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase, divergent, Flavobacterial type</fullName>
            <ecNumber evidence="2">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.75" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781638.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00013"/>
    <dbReference type="EnsemblBacteria" id="ACU06491">
        <property type="protein sequence ID" value="ACU06491"/>
        <property type="gene ID" value="FIC_00013"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00013"/>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104160_1_0_10"/>
    <dbReference type="OMA" id="NCFCVGE"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="PTHR12390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="45"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="224" mass="25602" checksum="F0BB30D2247F5F27" modified="2009-09-22" version="1">MKILFTKKFNKMMISKKLGSHFSYDFVEVIAITPMEVEAFNLKDQSLIFTSVNAVRSFFKNGFEPDENFASKNYNKIYTVGITTKRELRKFGFGTFKVTKHAKELSEFIIENSSKEKFLHFCGNLALDVLNKTLPLQNVSYRKIPVYETTLLYPQIAGNYDAVCFFSPSGVRSFAKFNSFENLAIFSIGETTANELKKFTQNPIITSKESNLDDLLKLISDHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH1</accession>
    <name>C6WZH1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00028"/>
    <dbReference type="EnsemblBacteria" id="ACU06506">
        <property type="protein sequence ID" value="ACU06506"/>
        <property type="gene ID" value="FIC_00028"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00028"/>
    <dbReference type="eggNOG" id="COG3137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057100_1_1_10"/>
    <dbReference type="OMA" id="EVAFVNW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021428">
        <property type="entry name" value="DUF3078"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11276">
        <property type="entry name" value="DUF3078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="371" mass="42967" checksum="4C9F5723A0D8EE26" modified="2009-09-22" version="1">MQAMRHLLCFFITCTSIFVYAQERRSIQQEIDSFSQRRWDSVTLDLDSLANPKLINFNAHFRDTLVIRDEVVIATVTNEIPVTPYNFLKLKEPKRWFYYGQNNLVFNQSSFSNWNSGGNNNIGIIGKVNYNLSYKNGRHFLDNHIQLGYGFVASEGESSRKTEDYINLMTNYGYDIGKDFYLSTGFQFLSQFSPGYNYTLTPDPVFSDRISRFLAPGYLNAGLGVSYNPNENFQVIFRPVNGKFTFVTDPFLQKAGRYGLEEDGQSVRSELGALLNILYRLKIHKEITFVNQINFFSNYVNHAERVDIAYNGTLNFRFNRFISTVISLDLVYDHDQLEKLQMKQTLGIGFSYNLGIENREKNKKLIKPFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH7</accession>
    <name>C6WZH7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease III</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nth</name>
        <name evidence="7" type="ordered locus">FIC_00034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781659.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00034"/>
    <dbReference type="EnsemblBacteria" id="ACU06512">
        <property type="protein sequence ID" value="ACU06512"/>
        <property type="gene ID" value="FIC_00034"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00034"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_10"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="208" mass="23696" checksum="314B51A2F6C13BD4" modified="2009-09-22" version="1">MTKKQRALTVMTELEKLYPEVPIPLDHSDPFTLLVAVGLSAQTTDKKVNQITPKLFEVAGDPYKMSILEVDEIRFLIKEIGLANTKAKNLKRMAEILVEKHQGVVPQTFEELEALPGVGHKTASVVMSQAFGVPAFPVDTHIHRLMKQWKLTDGKNVIETERDAKKLFPKTAWNRLHLQIIFYGREYSPARGSQEKDFITRMLFQPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ3</accession>
    <name>C6WZJ3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781675.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00052"/>
    <dbReference type="EnsemblBacteria" id="ACU06528">
        <property type="protein sequence ID" value="ACU06528"/>
        <property type="gene ID" value="FIC_00052"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00052"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_0_10"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="131"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="482" mass="54005" checksum="B0376EA009D1A71D" modified="2009-09-22" version="1">MSKYTEDDLRVDLENQKYEYGWETDIEYDEFPIGLNEGIVRMISAKKNEPEWMTEWRLEAFRIWLKMEEPTWANVKYEKPDFQGITYYAAPKKKPELASLDEVDPELLKTFEKLGINIEEQKRLSGVAVDIVIDSVSVKTTFQETLKEKGIIFCAISEAIRDYPDLVRKYIGKVVPRGDNFYAALNSAVFSDGSFCYIPKGVKCPMELSTYFRINQSGSGQFERTLLIADEGSYVSYLEGCTAPARDENQLHAAVVELIAMDDAEIKYSTVQNWFPGDASGKGGVFNFVTKRGICETRAKISWTQVETGSAVTWKYPSCILKGDHSIGEFYSIAVTNNHQYADTGTKMIHIGKNTRSTIISKGISAGKSNNSYRGLVKVMPSAKGARNFSQCDSLLMGNDCGAHTFPYIEIKDPTAQLEHEATTSKIGEDQIFYCNQRGINTEKAIALIVNGFGKEVLNKLPMEFAIEAQKLLEISLEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK2</accession>
    <name>C6WZK2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00061"/>
    <dbReference type="EnsemblBacteria" id="ACU06537">
        <property type="protein sequence ID" value="ACU06537"/>
        <property type="gene ID" value="FIC_00061"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00061"/>
    <dbReference type="HOGENOM" id="CLU_3403658_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="30" mass="3530" checksum="AC7DABF120D2DC35" modified="2009-09-22" version="1">MKFLNGKHKDDESGVFKLRNGKFIQKKHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU4</accession>
    <name>C6WZU4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781776.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00154"/>
    <dbReference type="EnsemblBacteria" id="ACU06629">
        <property type="protein sequence ID" value="ACU06629"/>
        <property type="gene ID" value="FIC_00154"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00154"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_1_10"/>
    <dbReference type="OMA" id="WWKGYNT"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973424" evidence="2">
        <location>
            <begin position="26"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="425" mass="48519" checksum="75487B9E1869F1D1" modified="2009-09-22" version="1">MTAFRRIIFLMILSFLLLSCKKETAQDQNPVSTLPNFGEIELDEIFKGRDNRLKNKDSIVSVIDQYYQKVWMKGDLWGGFLVAKGDEILYESYLGYGQGNKQMPVNDTVALHVASISKSVTAMAAMKLVEARKIELADPVTKFFPKFPYPKVTVFSLLTQRSGLPKYEYFIEKIEPEPAELSKKFLTNQDVLNMLVRYKPELSRQTDTGFMYCNTNYALLALIIEKVTATPFPEAMQQIIFRPLKMKNTYIFQEKDTATAAKSFFQRGPAVYPYDKLDAIYGDKNVYTTPRDLLNFSKAMFAENFLREDLHNMIFEPYSNERPGINNYGIGFRMKIYGNGEKLTYHNGWWHGTNSVFAHLLKSNVTIIAIGNKYSRRVYSSLALSGLFEDFPAETEKLQKIIQGSDTAKNGVAPDPTHGSDTYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW1</accession>
    <name>C6WZW1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781793.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00171"/>
    <dbReference type="EnsemblBacteria" id="ACU06646">
        <property type="protein sequence ID" value="ACU06646"/>
        <property type="gene ID" value="FIC_00171"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00171"/>
    <dbReference type="eggNOG" id="ENOG5030TGE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1624202_0_0_10"/>
    <dbReference type="OMA" id="LIMFATH"/>
    <dbReference type="OrthoDB" id="1410131at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973281" evidence="1">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="162" mass="17881" checksum="9F830DFB706D753F" modified="2009-09-22" version="1">MKKIIAFSAFLIMFATHFMQAQMAVHRALHVGYVYQNQSFGEVGGRLLFLSSDDVVYRLGASALMGSANGEFAIMPKVQGDILLNFERNVDFYHAYYFLAGAELTTKYIAPKIGATLFGLVDLTGGYAFSLDKKGINGKELKGLNINVTLNIPLVMLQDLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY2</accession>
    <name>C6WZY2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine-protein kinase wzc</fullName>
            <ecNumber evidence="8">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781814.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00192"/>
    <dbReference type="EnsemblBacteria" id="ACU06667">
        <property type="protein sequence ID" value="ACU06667"/>
        <property type="gene ID" value="FIC_00192"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00192"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_6_0_10"/>
    <dbReference type="OMA" id="VYGPKHP"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="7">
        <location>
            <begin position="608"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="825" mass="93883" checksum="C10225258C9BB3FE" modified="2009-09-22" version="1">MIPEKENKGKTADKSAVFALFDVEHFIRRVLQNWYWFVLMAALGYSVSWVYSKYYAQRIYASSLSLSISNNTASYFTPNQSINFIWGQNGNQDGIYLKKMLLSRSHNEYLVKQLDLFINYSTKGLIKQTYLDKYDSPVFLEVDKAHLQQVDYPITLIPKGGSRYEVVLPDEGETTSLYSYQTENFQNVRPYTRPANKIISVNEWYVTPNLKFKLVKNPQHTPIILENIILTLSTVNNTVNHLVSTIGVEFDKEINTIMIISKSGYNLNGTVNFLNTSVAELEKKRLVDRNTVDKNTEDYLYENLSKIRSKLDSSANVLNRMKVTEGLYDITDRDEKALKTIKELEAKKADLITKVNSLNNIRASLSSQNLDRMISLNAAGVEDGLFSASVSELKALHLKKREFALIYTPNSEPMREINRLINEARSNSTGSISNYYNTYSNEIAKINRDIAVESTGLVSYPEKERRYLDAERGYNMIEATYNSLLAKQNETQIRVATNKSDLTVIDPAKNLGQGPIAPDVQRTKYTIIGGLLLLPLLILGLSEVLDNRIRNIKELLQATRIPLLGVIGKNNHDNNLTVLEQPRSSISEAFRGIRANLRFLHKEDKQSKVILLTSSVGGEGKTYISINIASVLGLSGKRTILLGMDLRKPKIFGDFKIDNKFGISNYLTGEVEMDRIINQTKIPNLHVATAGPIPPNPSELLMSDRNIQFIEELKNHYDFIIIDSPPVGLVADPFELMKHADASIYVVRHEYTEKYMLKMITEKYHNHEVKNLGLIYNDYQAKQGYGYGYGYGYGYGYGYFDEDKNYREPTLIRIRNKITAILGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X017</accession>
    <name>C6X017_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_Swt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781849.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00228"/>
    <dbReference type="EnsemblBacteria" id="ACU06702">
        <property type="protein sequence ID" value="ACU06702"/>
        <property type="gene ID" value="FIC_00228"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00228"/>
    <dbReference type="eggNOG" id="ENOG5033CYR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060693_0_0_10"/>
    <dbReference type="OrthoDB" id="1489180at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041650">
        <property type="entry name" value="HEPN_Swt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18731">
        <property type="entry name" value="HEPN_Swt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_Swt1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="262" mass="31035" checksum="175BA3900456655B" modified="2009-09-22" version="1">MIDLQEFCAKSNIDDKKSKIDAVILLLYYAIAFEGSDGLSPNEINSLFEKAHLPLYNRTYLKRDLSKDKRTTPIPKTNKYKLTLGELKKLNMEYGYLLEKEIQINVRVDLNKTPLFDQSALEGAKKMSQLYIILYCWENSVRKVIEQTLTKKIGLDWWDDTKNKELENKYLDRKNKEEKQKWISPRGTQSPLYYLDWGDLIKIIRKNEHHFISQIPDIKFIELRLEELERLRNIIAHNGLVPDENDIDRIVVHFNDWCSQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X033</accession>
    <name>C6X033_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-succinylbenzoic acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781865.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00245"/>
    <dbReference type="EnsemblBacteria" id="ACU06718">
        <property type="protein sequence ID" value="ACU06718"/>
        <property type="gene ID" value="FIC_00245"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00245"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062005_0_0_10"/>
    <dbReference type="OMA" id="YHVSGLM"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="345" mass="38766" checksum="67CECC7964501AB6" modified="2009-09-22" version="1">MTLSFSENIDPSLLPQTEFEEKVVSFLEEWHSVRETVPVQTSGSTGTPKVFAIRKERMRHSANMTCDFLNLSPESSALLCLPVEYISGKMMVVRAAERNMKLTVSTPTSQPLQNITEFIDFCAMTPLQVQNSLDKIHLIGNLIIGGAQVAEHLKVNITDALKHSNTQSRVYETYGMSETLSHIALKQIYPKSEEFFTVLGDVQISQDERSCLSVFAPKLNPDRLQTNDLVEIKNATQFRFIGRLDNIINSGGLKIHPEELEELVKKHLKTEVIFAGLKDDRLGQKLVLGVEGARSTQLSNALNTALDAVETAFSKNHRPREIFYLNEFPRLPNGKISRRALIELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X059</accession>
    <name>C6X059_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplK</name>
        <name evidence="9" type="ordered locus">FIC_00276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4 6">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781891.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00276"/>
    <dbReference type="EnsemblBacteria" id="ACU06744">
        <property type="protein sequence ID" value="ACU06744"/>
        <property type="gene ID" value="FIC_00276"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00276"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_10"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="7">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="147" mass="15554" checksum="4CA5D81FBA785C34" modified="2009-09-22" version="1">MAKKVFKMVKLQVKGGAANPSPPVGPALGSAGVNIMEFCKQFNGRTQDKPGQVLPVVITVYEDKSFEFVIKTPPAAIQLMEAAKIKSGSGEPNRAKVGSVSWAQVQKIAEDKMTDLNCFTLDGALTMIAGTARSMGLRVTGTKPTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D4</accession>
    <name>C6X0D4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781966.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00352"/>
    <dbReference type="EnsemblBacteria" id="ACU06819">
        <property type="protein sequence ID" value="ACU06819"/>
        <property type="gene ID" value="FIC_00352"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00352"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081811_2_0_10"/>
    <dbReference type="OMA" id="GAHCIIN"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="206" mass="21462" checksum="C14D80275E0CA695" modified="2009-09-22" version="1">MIVYGASGHAKVIVDILLGIGIKVDKIVDADPAADEIFGIRVEKVSSETVFNADTQAVIAIGSNRIRKEIALRHPFLYTEAIHPRSCVSPYVIIGEGTVVMANVSVNPDVVIGKHCIINTGAVVEHDCILEDYVHISPNAALAGNVTVGEGSHVGAGVSVIPGIRIGKWATIGAGAVVIRDVPDGATVVGNPGRIIKTDTSDENAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0H7</accession>
    <name>C6X0H7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00396"/>
    <dbReference type="EnsemblBacteria" id="ACU06863">
        <property type="protein sequence ID" value="ACU06863"/>
        <property type="gene ID" value="FIC_00396"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00396"/>
    <dbReference type="eggNOG" id="COG1747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228605_0_0_10"/>
    <dbReference type="OMA" id="GEVWFNE"/>
    <dbReference type="OrthoDB" id="345734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026377">
        <property type="entry name" value="Cell_surface_SprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025684">
        <property type="entry name" value="SprA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14349">
        <property type="entry name" value="SprA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04189">
        <property type="entry name" value="surface_SprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972173" evidence="1">
        <location>
            <begin position="27"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="domain" description="SprA_N" evidence="2">
        <location>
            <begin position="51"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="SprA_N" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="2356" mass="265769" checksum="076A67E8C5DC3ADD" modified="2009-09-22" version="1">MEKNSFFQHKFFVFIILCFCSAQTFAQVTPSDSSSVRQDFSLPNPIRYDAFYDVSSGMYVLYPKIGNMVVGNPVSMTSEEYYQYMLNNQLSEYYREKSSVNNLGYRKDQSDAIQKGLLPSVNVKNKIFESIFGGNKIELIPQGFASFDIGGLYQKIDNPLILPQNRTNFAIDIQQRIQLGLLGKVGENLQLKANYDTQSGFAFENRMNLVWQAKGTWRDLQSKGLNDKTTGGEDKIIKRVEFGNVNMPLSTSLIRGSESLFGLKTEFQLGKTYGTVVFSQQQGEARNIIAQGGGVMNTFKLNAIDYEDNQHYYLGHYFLNSYDNALLNYPQINSRISITRIEAWVLDQGSGNLQDQKGILGIRDLGEGISGYPDNSQNGLYQGIVNLGAGIRDVNTAYNAINGQSFPNANGSPETYTDGEQFIFNRKARKLNANEFKYHPQLGYMSLNQRLNDNQLLAVAYSYTLNGDNKVYKVGEFSEESPVLITKLLKSNTKTTTTTPMWDLMMKNIYSLNSNDINQDGFLLNVYLRDAQNGKVNYLPGTPVQDVNLLKLFNWDRLNMNNDLQQNGTTTGDGIFDFVPGITVDPENGKVIFTKAKPFGAYLQSVLGSSDPKFVFNELYDQFKNVASENRLALSYTLEGRFKGSQGTGISLGAINVPQGSVKVTANGVQLQEGIDYTVDYMLGSVNIINETVKQSGQAINISLENQLSFNTQRKRFLGLNLERKFNEHLTVGTTVVNYAETPLTQKVNFGQEAVNNTMAGFNILYNNQLPFLTRLTDKIPFVNTEAPSNLSFTAEGAYLIPGQNKGIGDQSYIDDFEQTTSKISLKEPAMWSLASKPERNPEPYFQNATLNDNLAHGNGRGLLTWYNIDPRFYGIGGSAPGGINAQAVSNHASRRVQTQELYNSRDFVAGEQLYTNTFDITYFPNERGPYNVNPNNETTQERWGGLMRPISVSNFINSNIEYVEFWMMDPYADGNNLGSNPKLLLQLGNVSEDVLKDGKLQYENGLPTPTVPANTTTTNWGAQPNQFPILYAFSTENEERAAQDLGYDGLDAFGEQARFNTNFINPVTNTPDPASDDFLFYLSDKFQGPQASSLTERYKYFRNPEGNSQSNSLEVATQTPDAEDVNRDYNLDQSENYTQYTINLDRGSLAKGQKFIVDEKEVDVKFQNGQTGKNKWYLFRVPVTQFDDEPNSGGVRDLSILNNVRFARMLLTGFDQAATVRFGTLDLVRSDWRKYTKDIAALGNDSEGVNQVDNKNLDVGSVNLEENGLNQPPYVLPPGIDRQILSGNAGAQRQNEASLYMKAAPMEPKTSRGVFKNVALDMRRYKKLELFVHAEDARDVANSSLDADAKFFIRFGSDASDNYYEYEASLKYTPKNATSPMEIWPSENNVDLMIQNFVDAKLRRDGNDQIQIDERTEDMEFGTLDPDKKIFIKGRPSLGNVTTIMLGMRNNAAAESKEIVLWVNEIRLSEIENKGGYAGNASLNFNLGDFALVNANASYSTIGFGGITEKPAERAQSTFSAYSVNTTVNVDKFIPEKVGMKIPVNFSYTQTIEDPKYNPIDNDVTFEQAPNKEELKTVARTYTQQRSIGVVNMRKERMNPNKKPKFYDVENLSLTTVYNDDYFRDVYTKKNYRQYLRGYVDYNYSFKPWVLRPFNKIVSDTAKSYKYLRFIKEVNFNPIPTRLSFRTEIDRNYNELEFRNIEAILNGTTGQDFDVIKNRNFYFGWQYGLGFNFTKSLKLEINSAMRTLNDHLSVADMNSKSIFSDPLRAGRPVLYNHRVQLNYRFPFEYLPYLDFINAELGYGFTYNWNARSTVMTGFTNPETGVTESLGSIGQNTSNIVATSTVDVPKFFSKFKYFQNINTTMQKRKQEVDSLNNAYNLAWQKKNSKRNFKSYKFKNKLSPMQSVAYALTSIKTLDISYNENNGTVLPGLLSAPNWYGYGQTLGGPTYGFLLGSQADIRRTVIERGWISDSPYMNDPYTQIKNQNFLANVQIMPVNEFRIDVNFLKNYNSIFTQGGYNVDADSNAANGFQFSFGTDLITYSRTAWTFRTAFTDGKSIYDTMYQNARQIYQNSGAVFNEEEFANGKGLGDAYVLIPAFQAAVEGKSVNGELTDPKKSGFPLPNWRVTYSGLKNIPLVNTQFSKFDILHGYTSTYTASGIQSSVDYYNVQNNADAPQTDAFGNGFNPYTFSQVGYVEAFAPLIGADVTMRNNMQFRAQYNRDRMFMLGLVNHTLTEDVGKEYIVGFGYILKDLKMKINFKGKARNIKSDLNIRGDFSLRDSQTRITNILQNDSQVTGGQQMMSLKLSADYNMSQNFNLRFFYDQLLTKYKISTAFPLSTIRAGISATFTFTGAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K0</accession>
    <name>C6X0K0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate ABC transporter, phosphate-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00419"/>
    <dbReference type="EnsemblBacteria" id="ACU06886">
        <property type="protein sequence ID" value="ACU06886"/>
        <property type="gene ID" value="FIC_00419"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00419"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061152_1_0_10"/>
    <dbReference type="OMA" id="SSTVRYM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="16"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="278" mass="30922" checksum="4A9AA9B86E82F480" modified="2009-09-22" version="1">MVFLASCKKSDHVVDDPQQGHIAIAADESFKSVAEALTDRYMALNPGTKIDLIIKKEDLAFLDLLENKVRVIIMSRDLTDREKKAYKDKVDMDLLPAKFAADAVVFITAKDSQRNGVSVEELKKELNSDTKNIIFDGTNSSNLNFVAQKLGKKPGDLKFSIISGNTNIIKAIAAQPEKIGVVSLNTISRAYDKESQELRNSVKILPVVSGSSSISPDITNLRNMTYPFARILYFITNEGYYGLGNGLIRFSCQQLGQIVVQKEGLQPYNIFPREVQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0K3</accession>
    <name>C6X0K3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 6">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782036.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00427"/>
    <dbReference type="EnsemblBacteria" id="ACU06889">
        <property type="protein sequence ID" value="ACU06889"/>
        <property type="gene ID" value="FIC_00427"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00427"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_4_0_10"/>
    <dbReference type="OMA" id="CAPQVAG"/>
    <dbReference type="OrthoDB" id="715502at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="495" mass="54112" checksum="1C09F3715DD8B75B" modified="2009-09-22" version="1">MIYGTDILTIEDIIKIVADPSIATLNDEATERILKSQRNVREIVASDRTVYGINTGFGPLCDVKISEEETAQLQYNLIISHAVGVGKPIAKDLSKVMMIAKIHALSKGFSGVSLQVIERMILMVNKDIIPVVPEQGSVGASGDLAPLAHLVLPLLGLGKIWQDDEIIDTASVLEKHGLQPLTLGPKEGLGLINGTQFILAHAVLGLQRFEYLLDLADLTAAMSLEAYRGSASPFRAELHEIRPFDGSRKVAARMRKFLEKSENLHEHELCDRVQDPYSIRCVPQVHGASRNAFEHLKNLTETELNSVTDNPIILSAEESISGGNFHGQLLALPLDYSTLAAAELGNISDRRSYLLLEGKYGLPRLLTESSGLNSGFMIPQYTSAALVTENKTLCFPASADSIPTSLGQEDHVSMGSISGRKFNQVLGNLENILAVELMFAAQGLEFRRPAKCSVFVENAYSVIRSKVAKLEDDRLIGEDMLAIAELIRGRKFEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L9</accession>
    <name>C6X0L9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00443"/>
    <dbReference type="EnsemblBacteria" id="ACU06905">
        <property type="protein sequence ID" value="ACU06905"/>
        <property type="gene ID" value="FIC_00443"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00443"/>
    <dbReference type="eggNOG" id="ENOG5032RG9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139605_0_0_10"/>
    <dbReference type="OMA" id="FEDHTER"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="20389" checksum="1B4D5C7FC56DD034" modified="2009-09-22" version="1">MRRLKKNRNAEVIFSIQFNGKIKHMRKTLFILLFVLSGLGLKAQYGTISAILDELEERRGINKNLKDVNLDNSKFVLIKDFEDHTERSFIVIKGNLATYVEMFDDKQTGKSSSNVFSGDIVRSQHNIISLRADKLEGERIAMPVTKTLMLTKQKKVLYLIDVNTKDRWIEEGALNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M0</accession>
    <name>C6X0M0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="7">1.13.11.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00444"/>
    <dbReference type="EnsemblBacteria" id="ACU06906">
        <property type="protein sequence ID" value="ACU06906"/>
        <property type="gene ID" value="FIC_00444"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00444"/>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_1_1_10"/>
    <dbReference type="OMA" id="DPFPVKG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="115"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="313" mass="35741" checksum="2F80B00576816957" modified="2009-09-22" version="1">MVQQGKIRLVFTSGLNSNSPICEHQKKHGDGVKVLALWVDDAYSAFEETTKRGAKPYLEPLTLTDEQGEVRMSGIYTYGETVHMFVERKNYHGDFMPGYQKWVSNYNPTEVGLLYVDHCVGNVDWNRMIPTVEWYENVMGFVNILSFDDKQINTEYSALMSKVMSNGNGFAKFPINEPAEGKRKSQVEEYLDFYEDEGVQHIAVATKDIIRTVTELKARGIEFLPAPPNSYYDMVPERVGTIDEDIKKLSDLGILIDCDEEGYLLQIFTKPVEDRPTLFFEIIERHGAQSFGAGNFKALFEALEKEQERRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P4</accession>
    <name>C6X0P4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylmuramate--L-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00468"/>
    <dbReference type="EnsemblBacteria" id="ACU06930">
        <property type="protein sequence ID" value="ACU06930"/>
        <property type="gene ID" value="FIC_00468"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00468"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1419596_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="191" mass="21105" checksum="02117555950EEAB8" modified="2009-09-22" version="1">MKLKFQLLRNNFQMVSTGNFQSENFRTRVLILSSSVDHSVFIKQIFDFHGKSVDWSGAGSHSAKSDFTVLQTSDVTEAVHFKPTIVLISSEIADTDSAPVFSHITPGGVLVYPQSFEAVVEQANVYFRKLPYSPTDLNEKGGTQYLHTDMGDLPVSGLEVGVLADLDGIKLFCAQFGIMEEQFYEALAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0U4</accession>
    <name>C6X0U4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A2M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806342.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01611"/>
    <dbReference type="EnsemblBacteria" id="ACU08057">
        <property type="protein sequence ID" value="ACU08057"/>
        <property type="gene ID" value="FIC_01611"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01611"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001849_0_0_10"/>
    <dbReference type="OMA" id="SMYAPEF"/>
    <dbReference type="OrthoDB" id="231654at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041246">
        <property type="entry name" value="Bact_MG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17973">
        <property type="entry name" value="bMG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A2M" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1952" mass="224379" checksum="15B950207F4DC92E" modified="2009-09-22" version="1">MKNFTRIFILFLLISVFSPLFGQKYYDDQWKKVATNYKTGKYKSNLPIILEIQNQAMKDDNANQLIRSLKAEFSIVNQTQDDENNDSASQFFTKLSTFGNKLKGEQKLLYEVLLGEFFIDYYENESWEINQRTNINNQDFAQIETWSKLDFKNFLTKQFAELETKIAALQQVQLGKYKDIFEGTEDLGYFPTLFDWNTVNQIEFLKNSNFFTPNELKVNHAKIITLYDELIAKNTGNAKLYFQHKKINYNCGFLNCKDKFNQLQTLLNSGIDGDYKVLVIAEMMDLLSAEQKFTQALQLADSAKKQYPKSKFLDNIKNRENQITNPLLIIKFEDHTQSNRPIHLVAEAKNVSQFSLNIYELKDDVQNFMKYVRNSYDKNSFAAVKKSLVRKDMFELRDQKDYKPHKTSLEIKPLPSGIYLAEYVVDGAIQEHFYFIATQSRILYDKKDDRKLVDNQLKLVNRENGQSVSNEGLKIYEYSGAKTVTTTNQNTDKAANFRFPDSGSKEYYRYYLVQQPKSNDFNLIQVYGDRYYGGEDNNDRETAQIFLDRAIYRPGQTVYFKVIATAFNGKSKTENVVSKSKLNITLNNANGDEVSKQQLTTNEFGSVNGSFVLPLGKLNGQFYIEVDNDNEESDFLIDGTKYFQVEEYKRPKFEVTFEPVKDEYKYGQTIEVKGKAMMFSGVPLSNATVNYEIKKKNIRWMYFWWYPRGNDNENSILGDVKTNEKGEFTIRIDLKKDENLDGIQVDNYEINASVTDINGETQSETTNVKVASVSHYIKADDIKDSFTNENIKVKVETKNYNDQNLNKPYQVKLSKLLPPERIFRSNFQNEIQDLPKLSKQEFIQKFPHDYFSIDEKEPAIQSVILNGVQKTDESLDLGKLAAGKYSLELYNIEGKDTIKTEKTFEVFDKRFLVDTQKPFLKVLQPKSEFKRSEKARIYVYSAIPNALVNVYMQNGNGETITEQWKLRNGVLEYDLAFPNDESIDQVNVQFQIVAFNDVQTESINLKISSDKKPLRIETVTFRDKLQPNSKEKWTVKILGDDKEKVNAEVLANMYDMSLDQFAVNSWSWQQLYQKYFRMISYGIDQNLAQEHYSKRVPYINQKYINIPNFNWFDGGVYGRMVRQSAVVASAVRAQSEKMESRFEGMQMADSAIPSAPPPPPTAQEYPGQDGPLENEELKKIPVRQNLNETAFFYPNLMTDKDGNVTFEFTSPEALTQWKLMFLAHTKDARAATLEKEVVTQKEFSITPNYPRFLREGDELNLQSKLSSLVSQSLNGTAQLQILDAFTNEDISDRFGLIRNNSSAFALKENGNSVVNWNLKVPNDVSLIIIKVIAQAGNFSDGEQKAIAVLPNRMLVTDAVPIFVKEGQTKTFTLENLAKNNSTTATNVANTLELTTNPIWEIMFALPSLKNNQNGSADVVFNKWFADVLASEIFKANPKLKTVFDEYQQKGLLTSNLEKNQELKQLLLEETPWVLDSKDETEQMQKLARLFDANTMRNSIQTDWAELKQLQNPDGGFSWYQGYPSSYYTSLYILKNLGRINEWLKGNMTDYQGSEQKELVSKLIGYVDQEVNKYGNIDKKFVVNNFVLDYLDTRSYWEAQYPLKAKGTSLKNAVIAKAKTEKITDFTFFGLHRLALLFDKFGMKTESKKFLTYLKETSTETETQGVYWKQNLNDWGWYSSKTVNHAGALEVFNTLTPNDTDFIEEMKIWLVTQKEVNSWGSSRGTAEVIFTMLNSGKSWTSPESDKATIVWGGKELVNPDTKATGYVKSTVKPELIDKSLGTVTVTKPGPGIVQGGLFWQYYEDLDKIRSSESYISITKELYKKVKTVNGEELQKITSSTPLKVGDKVTVRMILNTDRNMEFIHLKDMRAAGFEPVNVISGYEWKNGLGYYQSTKDASTNFYIEYMPKGKYVFEYDYICNASGTFSNGITTLQNYYAPQMNAHTMGTRVTISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X5</accession>
    <name>C6X0X5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806373.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01643"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08088">
        <property type="protein sequence ID" value="ACU08088"/>
        <property type="gene ID" value="FIC_01643"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01643"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_19_1_10"/>
    <dbReference type="OMA" id="FQPRSFN"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="333" mass="38258" checksum="021390518CF2CFC3" modified="2009-09-22" version="1">MPTLSLIIAIYNRKNELFELLNSLSHQSDRAFEVIIVDDGSLIDLRPTCELFNESLAIQFFRKDNSGPGLSRNYGARRAKNDWLVFVDSDVIVEKNYIENIRKNLREKPCDAFGGADKAHKGFNLMQKAISYSMTSVFTTGGIRGNKKSITKFQPRSFNMGVRKSAFEKVGGFSEMRVGEDPDLSMTLWENGFTTAFYDDIGVYHKRRVDFGKFSKQVYQFGCARPIINQRHPAYVKISFAFPSLFLLGYVLGFLEYFAFQNGFILAMYGLYTILVFFHALYKTRNISTASFAIIATYIQMFSYGYGFLKSWILLNILRQKPEEAFPKHFHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X106</accession>
    <name>C6X106_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806404.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01675"/>
    <dbReference type="EnsemblBacteria" id="ACU08119">
        <property type="protein sequence ID" value="ACU08119"/>
        <property type="gene ID" value="FIC_01675"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01675"/>
    <dbReference type="eggNOG" id="ENOG50329R5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142887_0_0_10"/>
    <dbReference type="OMA" id="HDELHKW"/>
    <dbReference type="OrthoDB" id="1720941at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="159" mass="18016" checksum="5E5B32E5B0407EE0" modified="2009-09-22" version="1">MKNIIVPALLCLILFTACEKKHDSSADEDHTASIEQMATDHDKEDDHSATGVSLELDNGKKWATNAEMLPFIQQQEKLINEYDYDSGDYHKLAEDLNSANEKLIKSCTMTGKSHDVLHVWLNEHTSKITSLSKAGSKAEADKILDELEHSMETYRQYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X109</accession>
    <name>C6X109_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ordered locus">FIC_01678</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806407.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01678"/>
    <dbReference type="EnsemblBacteria" id="ACU08122">
        <property type="protein sequence ID" value="ACU08122"/>
        <property type="gene ID" value="FIC_01678"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01678"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_10"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="451" mass="50428" checksum="1EBA307E4CCDE539" modified="2009-09-22" version="1">MKPSLAKGTRDFTATEVVNRRAIINILQKNFELFGFQPLETPSFENLSTLTGKYGEEGDRLIFKILNSGDYALKTNGDDWNAKNSQKLIAQISEKALRYDLTVPFARFVAMNHGQLVFPFKRYQIQPVWRADRPQKGRYREFYQCDADVVGSESLWQEVELTQLYLKSFSELQIPVTIHLNNRKILSGLAEYAGITEQLIDFTVALDKLDKIGKDGVIKELLEKNISEESISKLDFLFSQSENALDNLKELKTKFAGNEIGTAGVDELEVVLTKCMDLGISSASLKFDITLARGLDYYTGAIFEVKANGVAMGSIGGGGRYDNLTEVFGVKNIPGIGISFGLDRIYLVMEELALFPQNAANAVKYLFANYGESEALEATKIIAKLRANGISAELYPESSKLKKQFTYAEKKGIPNLVFFGEQEIADRNITVKNLQSGEQETINLDTFLDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X122</accession>
    <name>C6X122_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806420.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01692"/>
    <dbReference type="EnsemblBacteria" id="ACU08135">
        <property type="protein sequence ID" value="ACU08135"/>
        <property type="gene ID" value="FIC_01692"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01692"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_10"/>
    <dbReference type="OMA" id="DWSGIYS"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="556" mass="63552" checksum="07F6884AC5E63BD0" modified="2009-09-22" version="1">MCGIICLLDAKQKTEILRPQVLEMSKKIRHRGPDWSGIFQDEKVIFSHERLAIVDPTSGKQPLFTKDGKVVLAVNGEIYNHQELRAEFPDYEFLTQSDCEIILALYRRDGKDFLEKLNGIFAFALYDTENDIYLVGRDHMGICPLYQGWDKNGNYYVASELKALEGVCKKIETFLPGHFLYSPDGYEMQKWYHREWDDFDNVKDNVTDISKIRESLEAAVHRQLMSDVPYGVLLSGGLDSSIIAAVTAKYARNRIESGDTQEAWYPRLHSFAVGLEGSPDLIAAQKAAEHIGSIHHEVHFTVQEGLDAVRDVIYHLETYDVTTIRASTPMYLLARVIKSMGIKMVLSGEGSDELFGGYLYFHKAPNAKEFHEETVRKLGKLHLYDCLRANKSLMSWGIEGRVPFLDKEFMDVAMTVNPKDKMINKAEGKMEKWVLRKAFEDLLPESIAWRQKEQFSDGVGYSWIDSLKELAEKEVSDEMMLNSRFRFPLNTPQNKEEYRYRTIFEEHFPSETAAATVPSVPSVACSTPIALEWDEAFKKMNDPSGRAVISVHEDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X150</accession>
    <name>C6X150_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806448.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01720"/>
    <dbReference type="EnsemblBacteria" id="ACU08163">
        <property type="protein sequence ID" value="ACU08163"/>
        <property type="gene ID" value="FIC_01720"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01720"/>
    <dbReference type="eggNOG" id="COG4867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055391_0_0_10"/>
    <dbReference type="OMA" id="GPYHTNT"/>
    <dbReference type="OrthoDB" id="171570at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="380" mass="43590" checksum="FB7B89D97E4527F6" modified="2009-09-22" version="1">MTDRQFTFRQGFTFTKHTPEEISHFDRVFEVFKDLLTHTSGDIEEAFEWLEMLDKEYDIFTDEYTLADFEEDLKKRGYIKEEKDPDDGNTGTGKGKNILTPKLEKALREFALDQIFGKLEKTGIGNHRTAKVGVGDERDGEHRAFQFGDDLSAVNMTESLKNAQINNGISDLRMTEDDLIVEETRHKAQMSTVLMIDISHSMILYGEDRITPAKKVAMALVELIKRKYPKDSIDIIVFGNEAWPIKIKDLPYLNVGPFHTNTVAGLELAMDILRRKRNTNKQIFMITDGKPSCIKLPTGELYTNSFGLDEMIVSECLTKAAQARRLKIPITTFMIAQDPYLRKFVEAFTAQNRGKAFLTGLSNLGEMIFEDYERNRIRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X164</accession>
    <name>C6X164_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar (Glycoside-Pentoside-Hexuronide) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806462.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01734"/>
    <dbReference type="EnsemblBacteria" id="ACU08177">
        <property type="protein sequence ID" value="ACU08177"/>
        <property type="gene ID" value="FIC_01734"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01734"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_0_2_10"/>
    <dbReference type="OMA" id="LPMAEWF"/>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="246"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="481" mass="53050" checksum="B2CC906E6D92DD0A" modified="2009-09-22" version="1">MSNNTQKITVVEKVGYSLGDLAANLVFQTLVTYLAYFYTDIYGLKAEDASLITLGVGLVAGFGFNPVIGALADRTTTRMGKFRPWILWTAVPLGVAALLAFSTPDFDYKGKVIYAAATYTLLLLLYAGNNLPYSALSGVITGDMGERNSISSYRFVAVMFAQFFVQVFMLPIILSAGDGDKAVGIEIVMTWLAIIGTIMLLITFFTTKERVIPKAGQVSNLKSDLKDLFNNRPWIIMLSVTTLIFITLAMKGGSYVYYFNNYVDEESLKNFISPITGFFSSIGLNFFGEDTRSAGFGLFNAGGIIMMIIGITFSKIFADKYGKRDVFMASLFISTLFVLLFIFYPPKSVGLMFTSQIMHGFFYGISTPLLWAMIADVADYSEWKNNRRATAIIFSAMMVGLKVGLSIGSSFVAWTISQYGYISSDGATSIIQPETVATGARMLVSIFAAIPFFIACGLLFFYQINKKMESQIESDLAERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X182</accession>
    <name>C6X182_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha-dextrin endo-1, 6-alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806480.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01752"/>
    <dbReference type="ESTHER" id="flab3-c6x182">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08195">
        <property type="protein sequence ID" value="ACU08195"/>
        <property type="gene ID" value="FIC_01752"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01752"/>
    <dbReference type="eggNOG" id="COG2819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039834_1_0_10"/>
    <dbReference type="OMA" id="AMSSAFW"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970532" evidence="1">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="376" mass="42094" checksum="F4BD0B5D493BAB34" modified="2009-09-22" version="1">MIKKGLPFVLFLCALSVQAQVQLVVTSVPADTPAGAKIYVAGSFNNWNPAATVLNKSSDGKFTVTIPETEGIAEYKFTRGSWETAEGNSAGNQLPNRSFTFTAKPQTINHQILSWPKPQIRKSTASPNVKILNENYAVPQLQTTRRIWIYLPADYETSKRKYPVVYMHDGQNLFDELTSFSGEWKVDETLDQLFGNGGKQAIVVGIDNGGSERLNEYSPWKNATHGGGKGGLYADFLANTLKPYIDKTYRTRPQARHTALMGSSMGGLITFYTGMRYPQKFGKLGIFSPSFWFAKDDVKSFIANNSNEIKRTRFYFLAGRKESAQMTADVEEIVPILLKNGARKKNIQTKFDDEGTHSESYWAKEFPAAYRWLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A0</accession>
    <name>C6X1A0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01770"/>
    <dbReference type="EnsemblBacteria" id="ACU08213">
        <property type="protein sequence ID" value="ACU08213"/>
        <property type="gene ID" value="FIC_01770"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01770"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_4_10"/>
    <dbReference type="OMA" id="HTGGIDG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973330" evidence="1">
        <location>
            <begin position="30"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="449" mass="50250" checksum="F39F8EB27D69CC9F" modified="2009-09-22" version="1">MLPIKKKPMIMYNKLFAVAFSGLVSLCYAQQGNREKLSGYLDSLAVHHKAMGSYAMATGGKPDFVKVTGFADVETKQRANMNTQYRIGSVSKIFTAVLVMQAVEEKKLSLQTKLSEFYPAIPNASKITVEQMLQHRSGIRNLTDEAEYWDYNLKPQTEKQITDTITKYASVFAPGEKHEYSNSNYILLGYILEKVNKKSYADLIQTKIAKPLKLTLTSVGSKISGSENQANSYIYNAGTFDKNTETDMSVPIGAGNLISTPTELLKFIIALENGKLVSKTSVDQMKNFQDGYGFGLAKVPFINKYGYGHSGRIDEFRSVLFYFPEDKVGISFVTNQSDYDVNQISINMLRTAMNMDFDMPDFKEKTVDVSILKKYEGTYKAPGFPLDIKIFTENGKLMAQATGQGAFALEVVSDTEFQFMPAGIKIKFNPQNNTFNFKQGANELIFTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B6</accession>
    <name>C6X1B6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806514.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01786"/>
    <dbReference type="EnsemblBacteria" id="ACU08229">
        <property type="protein sequence ID" value="ACU08229"/>
        <property type="gene ID" value="FIC_01786"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01786"/>
    <dbReference type="eggNOG" id="COG2732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121832_2_0_10"/>
    <dbReference type="OMA" id="PVEIDFI"/>
    <dbReference type="OrthoDB" id="2047621at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="11315" checksum="EF26DCF1A956AD27" modified="2009-09-22" version="1">MKTIYLDFAEIGDYEDFYAQLKEKLALPEFFGDNLDALNDFISGFSELPLHIEFVNLSVDQLETFEDLLLTLEDAEEEVEDFSFAYYLEQYEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B8</accession>
    <name>C6X1B8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806516.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01788"/>
    <dbReference type="EnsemblBacteria" id="ACU08231">
        <property type="protein sequence ID" value="ACU08231"/>
        <property type="gene ID" value="FIC_01788"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01788"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_10"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="262" mass="29703" checksum="9078EA66833F0EF5" modified="2009-09-22" version="1">MQTEKITERIVTWLKDYATKANVKGYVIGISGGVDSGVVSTLCAMTGLKVLAIEMPIRQKEDQINRAQEHIKFLESKFPNVEGQTVDLNEPFEALFRTFEVDEAHFPDQKLAFANTRARLRMLTLYYYGQINGLLVCGTGNKVEDFGIGFYTKYGDGGVDVSPIADLYKTEVYELARSLDLPESIKNAIPTDGLWDAERTDEQQIGATYPELEKIQKEWGNKTESDYSGRDLEVFRIFSKMNKAAQHKIQPIPVCDIPEEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C5</accession>
    <name>C6X1C5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5 YciO YrdC YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01795"/>
    <dbReference type="EnsemblBacteria" id="ACU08238">
        <property type="protein sequence ID" value="ACU08238"/>
        <property type="gene ID" value="FIC_01795"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01795"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_2_10"/>
    <dbReference type="OMA" id="LVDAFWP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="190" mass="21067" checksum="64BC51D4DF44E655" modified="2009-09-22" version="1">MPKSTLNTMQNLIDTLISGGTILYPTDTIWGIGCDATNVEAINKIFEIKRREKSKSMIVLVESVKRLQDIVDVPELAWDIMDLSEKPVTIIYDNPKGLPAELLAEDGSIGIRLIKDPYLKKLIGKLNKPLVSTSANLSGSKSPMKFSDISDEIISSVDAVSDENHDKVSEYSGSSVIRMWMDGRVKILRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q9</accession>
    <name>C6X1Q9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806657.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01930"/>
    <dbReference type="EnsemblBacteria" id="ACU08372">
        <property type="protein sequence ID" value="ACU08372"/>
        <property type="gene ID" value="FIC_01930"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01930"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_10"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="OrthoDB" id="1618609at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="181" mass="20886" checksum="3EFE087B9C63AD46" modified="2009-09-22" version="1">MNIKKTPLKDCYIIEPTIIGDERGYFYEKFNEKKWEDLTGLNGHFVQDNISKSTYGVLRGIHLQKGDHAQAKLVSCLEGKVFDVAVDLRESSPTFGQWFGVELSPENKLQLYVPRGFGHGFSVLSETAVFSYKCDNFYHKESEGSVIWNDKDLNIDWKLPENDILLSEKDRHLPTFSERNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1X3</accession>
    <name>C6X1X3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ordered locus">FIC_01994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806721.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01994"/>
    <dbReference type="EnsemblBacteria" id="ACU08436">
        <property type="protein sequence ID" value="ACU08436"/>
        <property type="gene ID" value="FIC_01994"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01994"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_0_1_10"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="19752" checksum="912253C73324F13B" modified="2009-09-22" version="1">MRHGKKFNHLGRTTSHRSALLSNMACSLIEHKRINTTVAKAKALRVYVEPLLTKGKEDTTHNRRTVFSYLQSKEAVAELFRTVAPMIAERNGGYTRIIKTGFRQGDAADMAMIELVDFNDIYNPNEEEKKATRRSRRGSSAKAETVTAEVKEAPAKEEAKAEETTGEAAESADHKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1X6</accession>
    <name>C6X1X6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="9" type="ordered locus">FIC_01997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806724.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01997"/>
    <dbReference type="EnsemblBacteria" id="ACU08439">
        <property type="protein sequence ID" value="ACU08439"/>
        <property type="gene ID" value="FIC_01997"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01997"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_3_10"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="129" mass="14016" checksum="52A1599BB0CDA012" modified="2009-09-22" version="1">MAKQTKVVKKRKVKVEAIGEAHIQATFNNIIISLTNKSGEVISWASAGKMGFRGSKKNTPFAAQMAAENCSQVAHDAGLRRVRVFVKGPGAGRESAIRTIHNSGIEVSEIVDVTPMPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X244</accession>
    <name>C6X244_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806791.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02065"/>
    <dbReference type="EnsemblBacteria" id="ACU08507">
        <property type="protein sequence ID" value="ACU08507"/>
        <property type="gene ID" value="FIC_02065"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02065"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010929_0_0_10"/>
    <dbReference type="OMA" id="PYSEQFY"/>
    <dbReference type="OrthoDB" id="470487at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Omp85" evidence="2">
        <location>
            <begin position="468"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="781" mass="88865" checksum="442E157F058937DD" modified="2009-09-22" version="1">MIKFNLTTYTKTAAICSVLLLNSCSNTKFLQEGQMLYIGGEVKIKNDTLSKKEKSNLSEALEEQLRPKPNTSFLGLRPQLYIYNITKEPKKEKGLRNWLKYKIGEKPVLLSDVDREFNEDIIVNYSENKGFFNAKAVSDTVSKNRKAKVIYTLTPGARYLISNVNFPEDSTVINSEIQAIKGETFLKSGNPFDLDVIKAERERIDEHLKNRGFYYFSDDNIVVQADSTVLKEPKVELFVKLKNNTPALAKEQFTINKTIVFPDYNIDDVKVGKYGIPYNTDSVEVIDDLYIVDPEKKFNPRIFNRALYFDKGDLYNRKDHNLSLNRLISLGVFKFVKNEFVVSDSLNHEFDAYYLLTPRPFQSLRLETLGKTSSANYTGGEVNLNWTHRNFFRGAEQLKAAVYGAFDVQIGGPKDANNIIRVGANAQLSIPRLVAPFRFRSSSAYVPRTNVELGYEYLSRTELYTLHNFNASFGYLWKENERKEHDLKVLDVTVVAPQNVSDKYNEQIYGNEAEGIRPNPSLQRVIDKQLIFGPTYTYTYTNTMLPQKNTFYYKGSLDLAGTIAGIASGADAKAGDQKEMFGIPFSQYTKMEHDLRYYRKVGDKSTIATRIIAGVGYPYGNSITIPYVKQFFVGGSNSIRAFRARTLGPGSYDPTVQNASFFFDQSGDIKLELNAEYRANIYKFLNAAIFADAGNVWLVNEDPERPGGKFSKDFVKEIAVGAGVGLRLDFNILILRLDLAMPLRIPYYEAGERWTFDRVNFGDRAWRRDNLILNIAIGYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X285</accession>
    <name>C6X285_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806832.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02111"/>
    <dbReference type="EnsemblBacteria" id="ACU08548">
        <property type="protein sequence ID" value="ACU08548"/>
        <property type="gene ID" value="FIC_02111"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02111"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OMA" id="KTTDITH"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="237" mass="26510" checksum="7CC6394C49938A3C" modified="2009-09-22" version="1">MIEIKSLTKKFNKFTALDNLNLSFTDSKSIALIGPNGCGKTTLIKCILGLNVIETGDILVSGKSVKDDYRYRKDIGYMPQIGRYPENMTIGQTIQMIKDTRKVPEDQLDKELMGDFELEKMYGKKMSTLSGGTTQKVSAVLAFMFDPKIIILDEPTAGLDPLASEILKNKIIKEKNKGKLIIITSHLLSELDDIVSEIVFMNEGKIIVQQSVTDLMSEHKSEKISESIISILKEMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E2</accession>
    <name>C6X2E2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="7" type="ordered locus">FIC_02169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806889.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02169"/>
    <dbReference type="EnsemblBacteria" id="ACU08605">
        <property type="protein sequence ID" value="ACU08605"/>
        <property type="gene ID" value="FIC_02169"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02169"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_10"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="318" mass="34681" checksum="E6A4366FC32FE6D9" modified="2009-09-22" version="1">MSWIKNIFKKEEKETLDKGLEKSSQGFFEKISKAVVGKSKVDEEVLDDLEEVLIASDVGAATTIKIIQRIEDRVARDKFVGTDELDRILREEISGLLLENPHASTGNIDETKKPYVIMVVGVNGVGKTTTIGKLANQFKSEGKSVVLGAADTFRAAAVEQLVIWSERVGVPIVKQQMGSDPASVAFDTVQSGVANNADVVIIDTAGRLHNKVNLMNELTKIKRVMQKVIPDAPHEILLVLDGSTGQNAFEQAKHFTTATDVNALAITKLDGTAKGGVVIGISDQFQIPVKYIGVGEKINDLQLFNGTEFVDSFFRKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H4</accession>
    <name>C6X2H4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoplasmic alpha-amylase</fullName>
            <ecNumber evidence="8">3.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_02202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806921.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02202"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08637">
        <property type="protein sequence ID" value="ACU08637"/>
        <property type="gene ID" value="FIC_02202"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02202"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_10"/>
    <dbReference type="OMA" id="FFHWYYP"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="DUF1939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="3"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="489" mass="56205" checksum="34169898DAE87FFB" modified="2009-09-22" version="1">MNPTMIQFFHWYSDGDAQLYEQVKNSADYLRELGISSVWLPPAYKSAGGGFSVGYDPYDLYDLGEFDQKGTVSTKYGNRQQLVEACRSLQQNGISVIADIVLNHKAGGDEKEIFHAVKVDPENRQQNISEPFEIESYTKFTFPGRGDQYSEFKWNFQCFSGVDYAEGHDGIFQIIHDHGDGWEEMIDDEKGNYDFLMYNDIEHRNPFVREELHTWGKWYHDQIFFDGVRLDAVKHQTPEFYKGWLYTLRADTGKNIFAVGEYWAPGELHLLQKYIDATEGSMSLFDSSLQHNFHQASNQGADYDLRQIFDETLTLANPLLSVTVVDNHDTQPLQALEAPVEYWFKPLAYALILLRENGYPCVFYPDLFGAHYTDKDAEGNDREIFLNKVEKIEELLKARQLFAYGPQRDYWEDANCLGWVREGDGEHPGCAVVLSNKDAYTKPMEMGLTYAGQNFYDYLGWFPEQVTIEENGWGNFPVPAGNVSVWVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2J6</accession>
    <name>C6X2J6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806943.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02224"/>
    <dbReference type="EnsemblBacteria" id="ACU08659">
        <property type="protein sequence ID" value="ACU08659"/>
        <property type="gene ID" value="FIC_02224"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02224"/>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057855_0_0_10"/>
    <dbReference type="OMA" id="CENSETI"/>
    <dbReference type="OrthoDB" id="1018664at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="276" mass="32322" checksum="1B4BC618D28DE68F" modified="2009-09-22" version="1">MKIKLLFALLFVYGWPAAQIKFENGYFIGNSGEKTEALIKDLDWNANPTSFLYKYSESDEVKTGAIKDVQEFRAYNGSKFVRTDVKIDRSGQRLNDLNYEREPEYRNETVFLKELVDGKVGLYKYSDGSNHRYFYKINDEEITPLIYKPYLVRHDQVSYNMDFQKQLEKSFTCKNATRPKFTDIKYEEKALFNLFVAQNQCLDPAFVQAEQTKSDKFNLNIRPRVNFSSLTLTRSSTGLETDLGSKTNFGVGVEFEYFLPFHKNKWAIIVEPNYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2M3</accession>
    <name>C6X2M3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NADP-dependent malic enzyme</fullName>
            <ecNumber evidence="12">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_02253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="12"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806970.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02253"/>
    <dbReference type="EnsemblBacteria" id="ACU08686">
        <property type="protein sequence ID" value="ACU08686"/>
        <property type="gene ID" value="FIC_02253"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02253"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012366_0_0_10"/>
    <dbReference type="OMA" id="NIWVTDL"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012188">
        <property type="entry name" value="ME_PTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036684">
        <property type="entry name" value="ME_PTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="11">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="10">
        <location>
            <begin position="170"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="765" mass="85036" checksum="CB1BAFA18AC07470" modified="2009-09-22" version="1">MPNKTNRDEKNFNQAALDYHRLEPKGKIEVIPSKPHSSQRDLSLAYSPGVAIPCLEIERDPRLAYEYTGKGNLVAVISNGTAVLGLGDIGAEASKPVMEGKGLLFKIFADINVFDIEIDEKDPDKFIEIVKGIAPTFGGINLEDIKAPEAFYIEQRLKEELHIPLMHDDQHGTAIISAAALINALEIAGKKIEDVKMVVNGAGAAAIACTKLYVELGLSKENILMCDSKGVINHKRENLTPEKIDFVAQTEIQTLQDAVKNADVFIGLSKGNVLTPEMLLSMAENPIVFGLANPDPEIEYDLAMATRPDTIMATGRSDYPNQVNNVLGFPYIFRGALDVQATGINEEMKLAAVHAIAQLAKEPVPEAVILTYNLKSLNFGREYFIPKPFDNRLITKVSMAVAKAAMESGIAGKPIENFDDYETALLDRMGRDEKLIRMMQNRAKANPKRVTLGNAEEYNVLKAAQILHEEGIAQPILLGDKKYIKEQMQKFGIDLDVPIVDPTDDDQEENRKIYRDDLWKLRQRKGVNEYKAKKYVRQRDYFGPMMLRNGHTDALIVGFSKNYSSTLRPVLEIIEREKGVDRVSSMMMILTEKKPIFFSDASIIQNPTSEDLVNIARMSEMVVKSFAIEPRIAMLSFENFAGISETSKKVAKAVSILHEKFPNMIVDGEIQPDFAMDADHLSDYPFSKLGTTPANVFVFPNLESANISYKIIRGMKVAQVVGPILMGLKQPVHVLQMRASVDEIVNLATIAVLDAQRREEAINKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z3</accession>
    <name>C6X2Z3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807090.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02373"/>
    <dbReference type="EnsemblBacteria" id="ACU08806">
        <property type="protein sequence ID" value="ACU08806"/>
        <property type="gene ID" value="FIC_02373"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02373"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_1_10"/>
    <dbReference type="OMA" id="HNVDILS"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="237" mass="26868" checksum="3DC8B66F458FA052" modified="2009-09-22" version="1">MKALIFAAGKGTRLKPFTDHHPKAMATVNGVPLLERNIQYVQSFGINDFVINIHHFGSQIREFLDKANNFGANIEISDEKDELLETGGGLVFARKFLDHGEDFLILNADILTDLNLNEFISYHQKNKAFATLAVSERKSSRKLLFNSDMILRGWLNSDTGEKKLADSDENLKPLAFSGIHCINPVIFNKITRTGKFSIMEEYLDLMQTEQIRGYEHHAKLIDVGRPESVLEAEKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X346</accession>
    <name>C6X346_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02426"/>
    <dbReference type="EnsemblBacteria" id="ACU08859">
        <property type="protein sequence ID" value="ACU08859"/>
        <property type="gene ID" value="FIC_02426"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02426"/>
    <dbReference type="eggNOG" id="ENOG5031W1I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198346_0_0_10"/>
    <dbReference type="OMA" id="FLYICTL"/>
    <dbReference type="OrthoDB" id="1637682at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="231" mass="26976" checksum="8575B8AF3B4BF963" modified="2009-09-22" version="1">MEGGGVCLLITTFAKKYKLIRLEQQNDWVIIIIVCCIFLYIFMLRSLRRDSSIPEFLLQKFPDSTNNFPSWVIIGAVFCLLFSVMISQYIPAVPKLIRSYHVFGYELNKFGFTFITIAAFYVTRGIMTYLFFAGTGWGRRWDVFYFTASKFYFIFSLLLLGMCVVEFYFPVDRGQLFSVYVAVVGVTFCAKIIFYMAHPAGMLPAEWYYKFLYICTLQIVPVLVLWKVFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X373</accession>
    <name>C6X373_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807170.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02453"/>
    <dbReference type="EnsemblBacteria" id="ACU08886">
        <property type="protein sequence ID" value="ACU08886"/>
        <property type="gene ID" value="FIC_02453"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02453"/>
    <dbReference type="eggNOG" id="COG3491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_10"/>
    <dbReference type="OMA" id="WHFGQYV"/>
    <dbReference type="OrthoDB" id="400496at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="168"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="315" mass="35496" checksum="DF3587BBE7BDC65D" modified="2009-09-22" version="1">MNKIPSVDLSDFLSGNPERKQKFVNEIGKAYEEIGFVALKGHFLDDDLVKDLYGEVKNFFDLPVETKQKYEIPGIGGQRGYVGFGKETAKGSKKGDLKEFWHFGQYLEEGSEYSSVYPDNLKVAEVPKFNEIGKEAYKMLEKTGVYVLRALALHLGLDEFYFDKFVGEGNSILRPIHYPPITEEPDNAVRAAAHGDINLITLLMGAQGRGLQVMNHDGEWIDAIAEPDELMINVGDMLSRHTNNKLKSTIHQVVNPPRELWGTSRYSIPFFMHPVGDMPLNALEGTYDENNPKLYPDTTAGEFLHERLVELGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X380</accession>
    <name>C6X380_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807177.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02460"/>
    <dbReference type="EnsemblBacteria" id="ACU08893">
        <property type="protein sequence ID" value="ACU08893"/>
        <property type="gene ID" value="FIC_02460"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02460"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_2_10"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="148" mass="16189" checksum="B3548EF5BA9E16BE" modified="2009-09-22" version="1">MSLENTISEAIKTAMREKDKTALDALRAVKAQIILLKTEGKGTEVSEDQEIAILQRMIKQRRDSFDQFTAQNRSDLAEVETAQMKVIEKYLPQQLSADELEAAMKAIIEETGASSVKDLGKVMGIAGKTLAGKSDGKSISEMAKKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A5</accession>
    <name>C6X3A5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807202.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02485"/>
    <dbReference type="EnsemblBacteria" id="ACU08918">
        <property type="protein sequence ID" value="ACU08918"/>
        <property type="gene ID" value="FIC_02485"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02485"/>
    <dbReference type="eggNOG" id="ENOG502ZTTK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2057214_0_0_10"/>
    <dbReference type="OrthoDB" id="2075393at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="13111" checksum="AF7540E9DFF50A04" modified="2009-09-22" version="1">MRNLLLLPLLYFLSSCGQEPQENEMVVRETPEMLSYDTTAIDSFSAGATSVDVAAEIRRSSRLYQDSIQKAKDLKAQTELLEKAKKTEEARKQSDAEKLKEQNRTKKAEEGASPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E9</accession>
    <name>C6X3E9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807246.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02532"/>
    <dbReference type="EnsemblBacteria" id="ACU08962">
        <property type="protein sequence ID" value="ACU08962"/>
        <property type="gene ID" value="FIC_02532"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02532"/>
    <dbReference type="eggNOG" id="ENOG502ZB6J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066214_0_1_10"/>
    <dbReference type="OMA" id="FASIKTH"/>
    <dbReference type="OrthoDB" id="1509557at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005901">
        <property type="entry name" value="GLPGLI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09697">
        <property type="entry name" value="Porph_ging"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01200">
        <property type="entry name" value="GLPGLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972268" evidence="2">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="298" mass="34388" checksum="B788563873D90133" modified="2009-09-22" version="1">MKKLLTLMFVSAFFALQAQQTVNRFFYELTFKPKKDSAKLEKVMMILDITKEKSIYRDYTMVAQDSILKIQVEQMQKSGVFKDMSKMVTMPKFSEKVYKFYPEMKVQYVERISSGFTPLNIGYNDETKMNWKITEEKAKIGSYNTQKATADFGGRKWNAWFTSDIPLQDGPYKFHGLPGLIVKIEDEGQNYSWELKGNKKVENFNEITYLESISPGGSGGKVSEVSREKFDKTFSDYKKDPFASMRPMLKPEMLTQKMPGSDTTIGDMVKQQEKMLKDFYGSNNNPIEINTQPAKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G1</accession>
    <name>C6X3G1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807258.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02544"/>
    <dbReference type="EnsemblBacteria" id="ACU08974">
        <property type="protein sequence ID" value="ACU08974"/>
        <property type="gene ID" value="FIC_02544"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02544"/>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106694_1_0_10"/>
    <dbReference type="OMA" id="VFMGVEN"/>
    <dbReference type="OrthoDB" id="1232828at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="19249" checksum="310F7D976724C98E" modified="2009-09-22" version="1">MSYKSKLKNIKAFVFDVDGVFTDGSVYLMPDKSMCRVMNVLDGYAVVKAIKNGYDICVITGGDDPSVRNRIHYLGITNYYAKISQKLEKYEEFRLKYNLQNDEILTMGDDLPDMSIMRASGISTCPENAVPEVKAVADYISPISGGKGAVRDVIEQVMKIQGKWHEDDTKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G3</accession>
    <name>C6X3G3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02546"/>
    <dbReference type="EnsemblBacteria" id="ACU08976">
        <property type="protein sequence ID" value="ACU08976"/>
        <property type="gene ID" value="FIC_02546"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02546"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116201_0_0_10"/>
    <dbReference type="OMA" id="WFFNGVF"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="206" mass="24143" checksum="0A68E7233BFB8A7D" modified="2009-09-22" version="1">MIQMSTDPRIDAYIENSGSFAQPILTYLRAVIHETCPEVVEDWKWSYPHFMYKGKILCAFMAFKQHCGFGFWLEQEMKTIKELTKNSERTRMFTLGKIKSMEQLPSEALLKAAIKEAMDLTDMGVTLKRNIPDKREIEVPDYFTEALHADKNALKVFENASPSFRKEYIQWITDAKTDATRTKRLEQALEWISEGKGRNWKYEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K1</accession>
    <name>C6X3K1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782136.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00531"/>
    <dbReference type="EnsemblBacteria" id="ACU06989">
        <property type="protein sequence ID" value="ACU06989"/>
        <property type="gene ID" value="FIC_00531"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00531"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_0_2_10"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="196"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="279" mass="31741" checksum="B7E182EC715885D0" modified="2009-09-22" version="1">MKIAFLGPQASFTQLATSQIFPDDDLIPQSNILDCFNAVKNGEVDKAVVPLENSIEGTVSMTLDYLYDFEDIYIETEAIMPISHHLMIHPNNENFTKVISHPQALAQTFHFRFDHYKNTETQDYSSTAAAAKLVSENPTEKWAAIANAYAAKLYGLKIIQQNIQDFEQNHTKFIVISRKRDQLKLKYSKTSEKTSLIITLPDDRAGALHQVCSVFAWRKMNLSKIESRTLKTGLGKYFFFINVASEWHPVLSQNAIQELELLGAKVKFLGHYDEYLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K5</accession>
    <name>C6X3K5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxybenzoyl-CoA thioesterase family active site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00535"/>
    <dbReference type="EnsemblBacteria" id="ACU06993">
        <property type="protein sequence ID" value="ACU06993"/>
        <property type="gene ID" value="FIC_00535"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00535"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_3_2_10"/>
    <dbReference type="OMA" id="YHASYLR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="151" mass="18004" checksum="4F40D9B22561153F" modified="2009-09-22" version="1">MIINKYICMLHLKCLMIHTTHSLRVRYAETDPMKYVYYGNYATYLEVARVELFRSLGMSYDEIENQGIWLPVSEFSIKYLRPALYDEMIEIHTFIKKTPGVRIDFEYEIYNSSNLKITEAKTTLFFLDAKTGKVIRCPDFLMELIEKNWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R5</accession>
    <name>C6X3R5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782200.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00598"/>
    <dbReference type="EnsemblBacteria" id="ACU07053">
        <property type="protein sequence ID" value="ACU07053"/>
        <property type="gene ID" value="FIC_00598"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00598"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_10"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="4"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="338" mass="38013" checksum="50D0192F6BD11B43" modified="2009-09-22" version="1">MTILVTGGLGYIGSHTVVELLKNNFQVIIVDDMSNSEKFILDNIEKVAGKRPVFFPFDLKRKELLSQVFDAYEIDGCINFAAFKAVGESQEKPLDYYENNLFSLINILQEFKTRNISNFIFSSSCTVYGQADQQPIDENTPLKTPESSYGKTKQMGEEILKDFATVHQRKISLLRYFNPIGAHPTALLGELPIGVPNNLVPYVTQTASGIREKLNIWGNDYPTEDGTAIRDYIYVVDLAKAHVKALQKLIASDEETVIDIFNLGTGRGSSVLEVVEAYERANNVAVPYQICERRAGDITIAYANADKAERELGWKAETSLEEALRTTWEWQKYLESRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y7</accession>
    <name>C6X3Y7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00670"/>
    <dbReference type="EnsemblBacteria" id="ACU07125">
        <property type="protein sequence ID" value="ACU07125"/>
        <property type="gene ID" value="FIC_00670"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00670"/>
    <dbReference type="HOGENOM" id="CLU_3025622_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="55" mass="5990" checksum="121A98EFDD0B4113" modified="2009-09-22" version="1">MKVLSRIVGGSFFGVSSASTLATAEDRAFRYIFFLQKKDAAAIAHAVTYSLKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X463</accession>
    <name>C6X463_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypoxanthine-guanine phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.8" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00746"/>
    <dbReference type="EnsemblBacteria" id="ACU07201">
        <property type="protein sequence ID" value="ACU07201"/>
        <property type="gene ID" value="FIC_00746"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00746"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_2_10"/>
    <dbReference type="OMA" id="TMDWMAV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="21931" checksum="05006F1745927F96" modified="2009-09-22" version="1">MLKYMESIHIHDKTFIPYLRDAEIQEIVKATALKIYEDYKDETPIFVGVLNGVIMFFSDLLKHYPGKCEIAFIQMSSYSGTQSTGIVYQKMELTKDIRDRHIILVEDIVDTGNTVESLFKYFTETQRPKSVKLASFLLKPDVYKKDFKLDYIGKEIPNKFVLGYGLDYDELGRNLKDLYQLEEGRINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X479</accession>
    <name>C6X479_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase subfamily IB, PSPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782363.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00762"/>
    <dbReference type="EnsemblBacteria" id="ACU07217">
        <property type="protein sequence ID" value="ACU07217"/>
        <property type="gene ID" value="FIC_00762"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00762"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052657_2_1_10"/>
    <dbReference type="OMA" id="FAWFAFG"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="195" mass="23064" checksum="404C9702E6273DEF" modified="2009-09-22" version="1">MKKLYLFDFDGTLTYKDTMFLFLKFYNPGKFYVEFAKHIPLFVLLKLKLTDAEKVKKSFISTILKGERQTRIEQKAKEFFDRFHKDIIRANARDFIKNIDRNQTESYIVTASLDIWVKPFAELFGMKLLATRAEFENEIFTGNFIGKNCNGDEKRCRIEQEFAGRKFDKTIAFGDTAGDREMMAWADESQFEFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X492</accession>
    <name>C6X492_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782376.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00777"/>
    <dbReference type="EnsemblBacteria" id="ACU07230">
        <property type="protein sequence ID" value="ACU07230"/>
        <property type="gene ID" value="FIC_00777"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00777"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_4_10"/>
    <dbReference type="OMA" id="QEWDVDE"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="422" mass="47037" checksum="EFD6F972EC5AB373" modified="2009-09-22" version="1">MKPSVISIVLGGGRGSRLFPLTYSRSKPAVPIAGKYRLVDIPISNCLNSGYNRILVLTQFNSASLNSHIKNSYHFDIFSRGFVDILAAEQNVESDKWYQGTADAVRQSMKHLTKYEYDYILILSGDQLYQMDFRELIEFHCQNESQITIATIPVNAADAPGFGILKSDEQGNITSFIEKPAPELLQDWKSEVSEKSKSEGKEYLASMGIYVFSKTILKKMFDEDPGDDFGGELIPNAIGSYKIMSFQYDGYWTDIGTIQSFFDANLELTQDLPKFNLFSNSPIYTRARMLPPSKILGSYVSKVIFGDGCVVMADKIENSIVGNRSRVDKGSTLINTYMMGADYYQNTEEIVSNDAQGRPNLGVGKYCYIERAILDKNCSIGDNVRILGAKHLPDGDFPTYSIKDGVVVVKKNAFIQPGTIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A2</accession>
    <name>C6X4A2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00787"/>
    <dbReference type="EnsemblBacteria" id="ACU07240">
        <property type="protein sequence ID" value="ACU07240"/>
        <property type="gene ID" value="FIC_00787"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00787"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110659_0_0_10"/>
    <dbReference type="OMA" id="QIGGNWC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970650" evidence="1">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="196" mass="22081" checksum="E40D4BB2B1BAE82E" modified="2009-09-22" version="1">MNKFKIKGMTMAMLLVSAVAFSQTAATKNAAETKNSVTPASKVDPAAALEEKKRIAAEEKAKLPKPYDAEENAEQKISELVKQAKAENKNIILQAGGNWCIWCLRFNQFVQTTPELKQIVDDNYLYYHLNYSPENKNEKVFAKYDNPGAKFGYPVFVVLNQDGKMIHTQDSAVLEEGKGYSIEKVKDFFLKWTSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4D8</accession>
    <name>C6X4D8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00823"/>
    <dbReference type="EnsemblBacteria" id="ACU07276">
        <property type="protein sequence ID" value="ACU07276"/>
        <property type="gene ID" value="FIC_00823"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00823"/>
    <dbReference type="HOGENOM" id="CLU_3118082_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="50" mass="5596" checksum="9DD0697EBF1B3952" modified="2009-09-22" version="1">MVFGVAKKINDYFGVESNLLTIAIGFAAMGLAFYSLIKQLNKIQKNETKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K1</accession>
    <name>C6X4K1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782485.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00886"/>
    <dbReference type="EnsemblBacteria" id="ACU07339">
        <property type="protein sequence ID" value="ACU07339"/>
        <property type="gene ID" value="FIC_00886"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00886"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142227_0_0_10"/>
    <dbReference type="OMA" id="GEWVRYS"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="120" mass="13568" checksum="73D3A0046911FA9E" modified="2009-09-22" version="1">MKNYKIQKSPFVVPTDDGKLIEEIWGNSTGNPEISIAHMVAPANWSEPFQTPEFDEFTYIIKGRKQFEIDGETVVLEAGESIRISKGARVRYSNPFAEPCEYIAICLPAFSMDLVNREAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L9</accession>
    <name>C6X4L9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782503.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00905"/>
    <dbReference type="EnsemblBacteria" id="ACU07357">
        <property type="protein sequence ID" value="ACU07357"/>
        <property type="gene ID" value="FIC_00905"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00905"/>
    <dbReference type="eggNOG" id="ENOG5031XRX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1466278_0_0_10"/>
    <dbReference type="OMA" id="WMIMCIP"/>
    <dbReference type="OrthoDB" id="1896564at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="183" mass="19800" checksum="B01C3262C378006B" modified="2009-09-22" version="1">MTNNLQTAQQDMRNGYGYGSSGVFSSGLVWLCAAVAVKLYGVNSGIWTLIIGGMMIFPLSMLIGKLLGIAGKHSSGNPLGKSAMEGTVWMIMCIPLAFGLSMQRPEWFFQGMLLIIGGRYLTFATLYGMRVYWLLGGLLAAAAWMLFTAQAGAFYSALSGGIIEVVFGTFLFVWFRKSRATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4M0</accession>
    <name>C6X4M0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782504.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07358">
        <property type="protein sequence ID" value="ACU07358"/>
        <property type="gene ID" value="FIC_00906"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00906"/>
    <dbReference type="HOGENOM" id="CLU_2259628_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973460" evidence="2">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="103" mass="11942" checksum="ACFFB137BF152BA2" modified="2009-09-22" version="1">MKKLLILGLMITGSATMYAQEGDNRYESIYRYYFYKITNEYPKNIPANPNCWQLKGDGSSCYAEGKRDGTYAGQQYMLNKNKEEKPGTTKDRKKLKSLMPYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N0</accession>
    <name>C6X4N0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782514.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00916"/>
    <dbReference type="EnsemblBacteria" id="ACU07368">
        <property type="protein sequence ID" value="ACU07368"/>
        <property type="gene ID" value="FIC_00916"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00916"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_0_0_10"/>
    <dbReference type="OMA" id="FNGTHED"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973690" evidence="1">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="111"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="340" mass="37718" checksum="2BA32F8A9565397D" modified="2009-09-22" version="1">MKKLLLPLLSAVVLTGCATVNYSYEGKAFQKSIHTITQGDLKEDLYVVASDDMEGRQTGSEGQKKAGRYMIEQYRKMGVSFPAPLKSFYQTVPASFMKTKTRGGSLPESENILAYIEGSEKPDEVIVLSAHYDHVGISNGQIFNGADDDGSGTVALLEIAEAFQTAKKAGHGPKRSILFLHVTGEEHGLIGSDYYSQNPVFPLANTVANLNIDMIGRCDPDNCGKDYVYVIGSEMLSTDLKKINVAANEKTVKLDLNYKYDDPADAQRLYYRSDHYNFAKHNIPVAFFFDGIHADYHKPTDDADKIDYSALQKRTQLVFATAWELANRAERIVVDGKNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4N1</accession>
    <name>C6X4N1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">FIC_00918</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782515.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00918"/>
    <dbReference type="EnsemblBacteria" id="ACU07369">
        <property type="protein sequence ID" value="ACU07369"/>
        <property type="gene ID" value="FIC_00918"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00918"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_10"/>
    <dbReference type="OMA" id="GSMYILD"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="586"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="626"/>
            <end position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU07369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="929" mass="104252" checksum="A684653E0AC23D6D" modified="2009-09-22" version="1">MTTTPDIDIKKQIFVKNAHLNNLKNIDVLLPKNKLIVITGVSGSGKSSLAFDTIYAEGQRRYVESLSSYARQFLGKLEKPKIDDIKGLAPSIAIQQKVISSNPRSTVGTSTEIYDYMKLLFARVGRTYSPVSGHEVKKDSVTDVIEHIQQNANQDFLLRSPLHFEVEKFQDLLNTLKVSGFTRLEVNGNVAGIEDLESFGFIPEKDMVIFLVIDRFRYDDDESFLQRLADSIQMAFYEGLGYCSLKNTETGKITEFSNKFELDGMEFMEPNVHFFSFNNPYGACPECEGYGKVIGIDEDLVISNKNLSVYEDAVASWKGESMSEWKKSFIKKVGTTFPVHKPYYQLTKEQKNFLWKGDGTRGFPSINSFFKMVEENLYKIQYRVMLSRYRGKTLCPTCEGLRLREETKLVKIDGHNIQEMIELPLDELLPLINALELNSHDAEIAKRLLYEITSRLEFLLKVGLGYLTLNRTSNTLSGGESQRINLATSLGSSLVGSIYILDEPSIGLHSRDTENLITVLKNLRDLGNTVIVVEHDEDVMRAADYIIDIGPEAGYLGGELVFAGNFEELQNSTSLTAEYLTGKLEIKVPEKRRKAKEFIQIKGARENNLKNIDVDIPLENLVVISGVSGSGKSTLMKEILTNEIQIQLGMGGKKGDYDSVEFPKKLIKNIELIDQNPIGKSSRSNPVTYLKAYDDIRDLFAKQKLAKIQNLKPKHFSFNVDGGRCDECKGEGVINVSMQFMADIELECETCKGARFKNEILEIKFDEKNISDILHMTVDESLEFFAENNEQKILTKLKPLQEVGLGYLQLGQSSSTLSGGEAQRIKLASFLVKGVTTDKTLFIFDEPSTGLHFHDINKLLTSLQALIELGHSVIVIEHQPDIIKSADYIIDIGPDAGKYGGEVVFSGTPEELVKSKKSHTAKFLVEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X520</accession>
    <name>C6X520_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805793.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01058"/>
    <dbReference type="EnsemblBacteria" id="ACU07508">
        <property type="protein sequence ID" value="ACU07508"/>
        <property type="gene ID" value="FIC_01058"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01058"/>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_5_0_10"/>
    <dbReference type="OMA" id="PIRNSAY"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="162" mass="17637" checksum="8785099522E9D166" modified="2009-09-22" version="1">MENKVNKNLAQIAELLIKNKLTIAVAESCTSGLLQNKFSLADDAMTFFQGGMTVYNAGQKAKHLNINPIFAEQCNSVSKEIAERMALNIADSFNAEIGISITGYAQPVPEDGIDSCFAHIAISKNDKVVLSSKINGDATLSLAENQEIYAVKIFEKLLRILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X522</accession>
    <name>C6X522_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01060"/>
    <dbReference type="EnsemblBacteria" id="ACU07510">
        <property type="protein sequence ID" value="ACU07510"/>
        <property type="gene ID" value="FIC_01060"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01060"/>
    <dbReference type="eggNOG" id="ENOG5033772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2022605_0_0_10"/>
    <dbReference type="OMA" id="NLEEWEN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="119" mass="13896" checksum="B815341BF1B527B7" modified="2009-09-22" version="1">MRVKLSTEIKKNLKMMSVLSLTFHTPEDLCQEWETYVKTDLLQMAENLMDVEKYILSEVASDMIGEGKNTNLLLIFENDEKRTDFVEIELINITEIIDAKFGQEIMIFETHLNPFGSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X539</accession>
    <name>C6X539_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805812.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01077"/>
    <dbReference type="EnsemblBacteria" id="ACU07527">
        <property type="protein sequence ID" value="ACU07527"/>
        <property type="gene ID" value="FIC_01077"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01077"/>
    <dbReference type="eggNOG" id="ENOG50330IV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142057_0_0_10"/>
    <dbReference type="OMA" id="GRIREWI"/>
    <dbReference type="OrthoDB" id="1753156at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="128" mass="14034" checksum="79803E95571290FE" modified="2009-09-22" version="1">MKKQKIIMAITTGIFGLSMLFSAYMYLTDAEVKAGFSSHLGIPDYLRVELAVAKILGSLALMLPFVPKGFKYFAYAGFTINLISASVAHIAVGDPASQVVMPFVYLVILAVSFIYYRKLEKGKQNIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X561</accession>
    <name>C6X561_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805834.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01099"/>
    <dbReference type="EnsemblBacteria" id="ACU07549">
        <property type="protein sequence ID" value="ACU07549"/>
        <property type="gene ID" value="FIC_01099"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01099"/>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019601_1_0_10"/>
    <dbReference type="OMA" id="YTPRIIE"/>
    <dbReference type="OrthoDB" id="1339473at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="762" mass="89192" checksum="D42575E073A84C22" modified="2009-09-22" version="1">MEYDFSKLNDREFEILAASVIEKDLENKVEIFKSGRDGGVDGRFWIGDKKEGIIQCKHYQETPYPQLISKLKTEESDKVEKLNPCRYVFVTSKKLSRINKQEIKSIFQPYILTEGDIWGQEDLNTFLSKKENQDIVERNYKLWITSTSVLEILYNSAIKGRSQSTIREIEEKTHRYVVTENHNKGLRILEENNVIILTGEPGIGKTTLGDNLAIHYIAKGYEFCDIEENVSEAESLFRENEQKKILFYCDDFLGSNIYDAVNNKRDSHIVKFINRIRKDNSKKFILTSRTNILNKAYLSSHSFQNLKIRENEFLLTIENLTNIDKAKILYNHIYHSNLPKQYIDIIYEDKRYKDILKHRNFNPRIIEFINDSSVVGNIKPEDYWSHIIKSLNKPQVIWEGYFQNQTDDCVRALTFLTVFNNGKIPEDDLRNSYNNFLNIHQVNLGDYSDKSFEAVRKLATKSLLNRNLLGDNKYEYVLFNPSIADFVLGSYSSEVELICNIVKSLDSEVSLDFLHGLLRSEKITNNNLNRILESLFDYFFERKLQEEDWDFLIALSYINFFNDIINKRIGLFLNTLVNTDKPSGDRLWELLMILSDFEPAIKYKNFNFLYNFINDVDDEDSLKKLLDFVDENEIGDENILVQIDILIDRYLRSIVDNNDLDIDFHKHIRQTYSYEGHPEMDVDISGIEDEIRENLDSFLDGFNVNVLDRISFSTSSIVSGVDIDSKVTRYLENYEPDYDKDAHRPYFSDSSSGDDIDAIFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X573</accession>
    <name>C6X573_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01111"/>
    <dbReference type="EnsemblBacteria" id="ACU07561">
        <property type="protein sequence ID" value="ACU07561"/>
        <property type="gene ID" value="FIC_01111"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01111"/>
    <dbReference type="HOGENOM" id="CLU_3025623_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="55" mass="6215" checksum="83E2BD0D652B893C" modified="2009-09-22" version="1">MLEKGRQELAVSCGIMSSSNFLHLFSEIYGTSLSEYREQCRKKFAGEEGQNHSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X576</accession>
    <name>C6X576_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01114"/>
    <dbReference type="ESTHER" id="flab3-c6x576">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07564">
        <property type="protein sequence ID" value="ACU07564"/>
        <property type="gene ID" value="FIC_01114"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01114"/>
    <dbReference type="eggNOG" id="COG2819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448884_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="608" mass="71448" checksum="DBF70941FB79B828" modified="2009-09-22" version="1">MGEDHAVKENLDFVKSLIPELYEAGVYNLCMEFGSYEKQQELDELLNADLFDERKAKDMFFFYNVGWAYKEYFDLYKAVWAFNRTLPRDAKKFRIVNLSYQYRWENFKGGARTPENMKAVFNLGTPDRFRTEIIKKEIISKDEKALIYMGHVHVFTRYRMPILKMNSDDFCDYDEGMVGNRLYRLMPGKIFNIMFHTPMFSKTQYNPAYVSPATGELENALQQLNYPQIGFDLINTPVGKLRDNSFFSFCHSDFKMEDFFDGYIFLKPFKDLTGCTFDDDFFTGKDWTSIENNFPDPDWRKPKNLEEYKTAVKKYVNLKDRYKEVIQTSVPSVGFGKIIRINQFPSKYVAPRNVDVWLPEHFNPNKKYAVLYMHDGQMLFDGAVNWNHSEWKVDENYTALSTKIKLKDCIIVGLWNTGATRHSEYFPQKVFERLSEELQNQTLEKYFAGKVQSDHYLKFIVEEVKPFIDKNYPTLKDRANTYIAGSSMGGLISMYAMCEYPEIFGGAACLSTHWIGITDLLNDEIPTAFQNYLRQKLPDPKTHTIYFDYGTEGLDSHYEKHQKKVDQLMKEKGFDKNNWATRKFEGADHSENAWSQRFSIPLEFLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X578</accession>
    <name>C6X578_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805851.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01116"/>
    <dbReference type="EnsemblBacteria" id="ACU07566">
        <property type="protein sequence ID" value="ACU07566"/>
        <property type="gene ID" value="FIC_01116"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01116"/>
    <dbReference type="eggNOG" id="COG2094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060471_4_1_10"/>
    <dbReference type="OMA" id="VEAYHHT"/>
    <dbReference type="OrthoDB" id="1385409at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="175" mass="19354" checksum="CFD3B7673E0ABDFB" modified="2009-09-22" version="1">MPERLPISCFQKNDAVHMAQTLLGKILVRKFPDGRELRSHITETEAYCGSGDLASHASKGRTPRTELMFGDGGFVYVYLIYGRYWLLNIVTGKAGQPEAVLIRGLSTVSGPGRIGNLLELDKSFYGENLGSSKRLWIEDSVMEGTVTAGPRIGVDYAGEVWKNMPWRFVLNAVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X588</accession>
    <name>C6X588_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01126"/>
    <dbReference type="EnsemblBacteria" id="ACU07576">
        <property type="protein sequence ID" value="ACU07576"/>
        <property type="gene ID" value="FIC_01126"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01126"/>
    <dbReference type="HOGENOM" id="CLU_3025624_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="55" mass="6119" checksum="46C721F983F40719" modified="2009-09-22" version="1">MATSVRKTSGIIPETVPATNKNQLHPNTITMTALFILAIAVFLYIVYVLLKPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5A4</accession>
    <name>C6X5A4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805877.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01142"/>
    <dbReference type="EnsemblBacteria" id="ACU07592">
        <property type="protein sequence ID" value="ACU07592"/>
        <property type="gene ID" value="FIC_01142"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01142"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074799_0_0_10"/>
    <dbReference type="OMA" id="WEAKAFI"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="257" mass="29619" checksum="3996AA1B39EAEC06" modified="2009-09-22" version="1">MSILSDNMRVLRDRLAISQQKTADSLKITRGRYVKYEDGSSEPPIEILVRIARFFNISIDLLLTVDIRKYPLDNIAALPNNRIVLPIIVDEQGENKIEIVTQKASMGYLTGYTDPDYIESLQTLSLPFLRNGKYRAFPAGGDSMPPYSDGTFIVGKYVERREDLKKGKTYLFITREGIVYKRYAKQNKNGTLISSDNTFYEPYEIPWSEVLEIWEFASSINTKEISPEWVENLNTKEMFLNLIEEINHLKNLVSDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C3</accession>
    <name>C6X5C3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01161"/>
    <dbReference type="EnsemblBacteria" id="ACU07611">
        <property type="protein sequence ID" value="ACU07611"/>
        <property type="gene ID" value="FIC_01161"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01161"/>
    <dbReference type="HOGENOM" id="CLU_1553027_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="105"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="20166" checksum="B4EC337B8657D305" modified="2009-09-22" version="1">MPDNSSMIIKTQVTFKQYARLLFGLTYQRPVMKLLLGVAALLALWITFYYLNLFDLPMPIVYQYITLGLILLVQPIVIFTTIYTVYHSSNQICEPLEMEFLPVAIKIHGNSFYMEVKWEKMFKIIEKPSWFLIYQNSLSAIIIAKKDLENEEILELRKILHAIENVPIQLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F5</accession>
    <name>C6X5F5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805928.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01195"/>
    <dbReference type="EnsemblBacteria" id="ACU07643">
        <property type="protein sequence ID" value="ACU07643"/>
        <property type="gene ID" value="FIC_01195"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01195"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_10"/>
    <dbReference type="OMA" id="MGTDNIP"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="267" mass="29259" checksum="71738DB156DEF102" modified="2009-09-22" version="1">METQKTYTLITGGSSGIGYELAKLFAKDGHNLILAARDETALSNAAEALKNLGNIDVITISKDLFHMEQADELYREIRGKNLTVDILVNNAGHGWYGKFEETELEMELSIIHLNICSLVILTKHFLKDMVAQGSGKILNTSSIASKFPGPWQSVYHGTKAFVQSFTEALRAEVKEHGIVVTALLPGPTDTDFFNKAGMEVSKVYEQDKLADPADVAKAGYDALMSDKDMVVPGLKNKMQAAQTAVTPDEMLAKKTYKDQEPKDSEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H4</accession>
    <name>C6X5H4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805947.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01214"/>
    <dbReference type="EnsemblBacteria" id="ACU07662">
        <property type="protein sequence ID" value="ACU07662"/>
        <property type="gene ID" value="FIC_01214"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01214"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038153_1_0_10"/>
    <dbReference type="OMA" id="GHVLRCE"/>
    <dbReference type="OrthoDB" id="763914at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026889">
        <property type="entry name" value="Zn_Tnp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14319">
        <property type="entry name" value="Zn_Tnp_IS91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS91" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="368" mass="41901" checksum="6F572D0E5503F9E3" modified="2009-09-22" version="1">MQARSNDGSVAEVLRKINLSSQNFSVHQEKTLRALSNCRTSALGGHIDTCDGCGNLSISYNSCRNRHCPQCQGHKKEEWIQKREQDLLPCTYYHVVFTLPEELSALALALPKLIYKALFEAAWATLNQFGKTEGLQLGMIGVLHTWGQNLSLHPHLHCIVPGGGLTMQGKWRKKVRTNKYLFAVKALSKVFRAKFVASLRACGITDRDLMEKLFTKNWVVYAKRPFGGPKQVIEYLGRYTHKVAISNHRIKEITDQQVRFGYKDYRKGGAKKEMTLSNQEFIRRFSLHILPRRFVRIRHYGILSSSWKRGKLQALQSDLKIRVTAAKPKTLLRKCRSCKEGNLVTIAVFGQRGPPQDFLFVTQPLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K5</accession>
    <name>C6X5K5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01245"/>
    <dbReference type="EnsemblBacteria" id="ACU07693">
        <property type="protein sequence ID" value="ACU07693"/>
        <property type="gene ID" value="FIC_01245"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01245"/>
    <dbReference type="HOGENOM" id="CLU_3153079_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="48" mass="5383" checksum="8437029161B261EF" modified="2009-09-22" version="1">MRNEPDADPGIVMGRYRRLDVQRTAFFDEGNAPENVAAVRCGPAGWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L6</accession>
    <name>C6X5L6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805989.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01256"/>
    <dbReference type="EnsemblBacteria" id="ACU07704">
        <property type="protein sequence ID" value="ACU07704"/>
        <property type="gene ID" value="FIC_01256"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01256"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="OMA" id="HKHDFFI"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="297" mass="33600" checksum="BA58D97C1FABE0F8" modified="2009-09-22" version="1">MPDTSTSYRAVTVTNLNMPTPFGGEFAVLCAEKLNTVLAAEKSFKSKFYLLITVKSGTGTLSLDNTAYEIKGGRVFYINYNQIFSFSADTDFEGKLLFFTRSFYNMIYTGNTKIKNDTAFSGLPTYLDFKKNDFTGFMLGIADIHNETSKNALRSKEIVCLLLKVAMLKYIQKSGNAQHADFRTDRKVSYVEDFASLVDANFKELKRTSDYAAKLSITPNYLNAVVKERLDISAERYIQNRVILEAERLLLNTHLSVTEISYELGFSDKSHFGKYFRKIAGETPNRFRKKAGAAEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L9</accession>
    <name>C6X5L9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01259"/>
    <dbReference type="EnsemblBacteria" id="ACU07707">
        <property type="protein sequence ID" value="ACU07707"/>
        <property type="gene ID" value="FIC_01259"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01259"/>
    <dbReference type="HOGENOM" id="CLU_3396630_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="31" mass="3708" checksum="2D6065F4AB61E6A5" modified="2009-09-22" version="1">MKTTPDSPMDFPFYLQYSHFFYIFTPKISGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M8</accession>
    <name>C6X5M8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01268"/>
    <dbReference type="EnsemblBacteria" id="ACU07716">
        <property type="protein sequence ID" value="ACU07716"/>
        <property type="gene ID" value="FIC_01268"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01268"/>
    <dbReference type="HOGENOM" id="CLU_3356318_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="36" mass="4275" checksum="36D299B0564BB017" modified="2009-09-22" version="1">MNSAQRICRNFLLKNLIFAHFEKNIMITANHLRVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5N3</accession>
    <name>C6X5N3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase, P-type (Transporting), HAD superfamily, subfamily IC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806006.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01273"/>
    <dbReference type="EnsemblBacteria" id="ACU07721">
        <property type="protein sequence ID" value="ACU07721"/>
        <property type="gene ID" value="FIC_01273"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01273"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_10"/>
    <dbReference type="OMA" id="GVHRMAK"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="739"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="786"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="890" mass="97250" checksum="D009B5437D842D8D" modified="2009-09-22" version="1">MWFTKSIDETLKELSVNPATGLTAEEVLSRKSKYGPNRLKAKKKKSVFQIFISQLNDWLIYVLFAAVIITFFMGEYIDSVIIILVILINAGIGVFQEVKAGKAIEALMQMSSPRALVRRDSHTAEIDSAELVPGDIVILDAGRVVPADLRLIESANLQTEESALTGESVPGSKEAGNVHDDPKIPLGDRDNQAFMSSIVTYGRGVGVVVETGMRTEVGKIAHLIDNEEVTKTPLEKKLSELGKMLGKMAVGICAFIFVLSWFQRRDLGEMFLTSVSLAVASIPEGLAAIVAVVLSVGVTTMSKNNAIIRQLPAVETLGSVNVICSDKTGTLTMNKMSVTQVYTTQGLLDLDDLVPNDVPNAAKFAAKAMILCSDATLHNDDATGDPTEIALLALGDTLRLDRKNLENDTNRINEKSFDSDRKMMSVLVKEEDGDYKVFTKGALASLKKVSTRIFNNGEVREITEADLQNFSHAARQMSDHALRTLAVAYKPAARDTHPDEMEQDLVLLGLVGMIDPARDEVKPSIKLAKDAGIKTIMITGDHKNTAFAIAKDLHIADHVDQVITGPEMDSFSEDELKQKVNSYRVYARVSPEHKVKIVRALKANGNIVSMTGDGVNDAPSLNAADIGVAMGITGTDVAKGAADMILTDDDFSTIVKAIEQGRNIYNNIKKSVIFLLTCNLGEVVVMFLALLVGWQSPLIATQLLWINLLTDSLPAIALGMDNGDPDVMKEKPRAINENFFSHGAGMQAVVGGIFIGLITMLAYWYGYYELGYSPSDDNIPEEVVKNARTLAFMVLVCSQLFYSLGLRNMKKPLYKIGIFGNRYLVGAIVLGILLQVLVMFVPVLREAFKLHMLDQKGWMMAIVLGLLPLTALEIYKIVFANRKQPSTTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P6</accession>
    <name>C6X5P6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">FIC_01286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806019.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01286"/>
    <dbReference type="EnsemblBacteria" id="ACU07734">
        <property type="protein sequence ID" value="ACU07734"/>
        <property type="gene ID" value="FIC_01286"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01286"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_10"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="236" mass="25731" checksum="F2353794248D5F21" modified="2009-09-22" version="1">MKYQRILLKLSGEALMGDRPYGIDNERLKEYAAEIKKVVDLGCQVAIVIGGGNIFRGLAGAAKGMDRVQGDYMGMLATVINGMALQGALEDAGIHTRLQSAIEMDKVAEPFIKRKATRHLEKGRVVIFGAGTGNPYFTTDTAATLRAIEIGADVILKGTRVDGIYDSDPEKNTNAVKFNSLTFDEVYAKDLKVMDMTAFTLSHENKLPIIVFDMNKEGNLVKIVEGEEIGTLVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q3</accession>
    <name>C6X5Q3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpD</name>
        <name evidence="12" type="ordered locus">FIC_01293</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806026.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01293"/>
    <dbReference type="EnsemblBacteria" id="ACU07741">
        <property type="protein sequence ID" value="ACU07741"/>
        <property type="gene ID" value="FIC_01293"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01293"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_10"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="147"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU07741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="502" mass="54306" checksum="C41374F710CC69D0" modified="2009-09-22" version="1">MANQIKGKISQIIGPVLDVVFADAAELPNIYDALEILKEDGNKVILEVEQHIGEDTVRCIAMDATDGLQRGQEVISQGRQITMPTGDAVYGRLFNVVGDAIDGISQVSKENGLPIHREAPKFDQLSTSAEVLFTGIKVIDLVEPYSKGGKIGLFGGAGVGKTVLIQELINNIAKGHGGLSVFAGVGERTREGNDLLREMLESGIIKYGDEFMHSMENGGWDLSKVDLEEMKDSKCTFVFGQMNEPPGARARVALSGLTIAENFRDGDGQGQGRDVLFFVDNIFRFTQAGSEVSALLGRMPSAVGYQPTLASEMGAMQERITSTKNGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLDRKIASLGIYPAVDPLASTSRILTPEILGAEHYDCAQRVKEILQKYKALQDIIAILGMEELSEEDKLSVYRARKVQRFLSQPFHVAEQFTGLKGALVDIKDTIKGFNMIIDGELDHLPEAAFNLKGTIEEAIAAGEKMLAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T9</accession>
    <name>C6X5T9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein, LuxR:Response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01329"/>
    <dbReference type="EnsemblBacteria" id="ACU07777">
        <property type="protein sequence ID" value="ACU07777"/>
        <property type="gene ID" value="FIC_01329"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01329"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_10"/>
    <dbReference type="OMA" id="YKKRLMQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="221" mass="25291" checksum="6A062AE4B5796A5A" modified="2009-09-22" version="1">MKLMETNINVVIIDDHNIIIEGLEMLLSLRKEINIVQTYNDANDFISDLRNQKYIPHIVLMDLMMPTINGYEAAKILKKEFPVVRIIILSMDCASKTIYDLVEKIGVEGYLSKKISAKELYFALKQVDSGYVHFSDEAAKALDSFREKIISYPSIKLSEREKQIVKLMFAGFTNTEIAAALFISISTVETHRKNIYRKTETHSLPKLMQLVTDLQLLDGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W3</accession>
    <name>C6X5W3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806086.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01353"/>
    <dbReference type="EnsemblBacteria" id="ACU07801">
        <property type="protein sequence ID" value="ACU07801"/>
        <property type="gene ID" value="FIC_01353"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01353"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_18_3_10"/>
    <dbReference type="OMA" id="YTTDFFQ"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="138" mass="16197" checksum="3651B8072ABA305F" modified="2009-09-22" version="1">MIDKINIRVYGAVVKDRKVLVLHEEYVGQNLMKLPGGGLEFGEGVLGCLHREFEEELNVKIKIKEHLYTQEDFLVSRFRANEQLLTLYYIVEIIDEEEFLILDPCIEKTEWVPIDTDENPFPLPIDKIAFEKLKEKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W5</accession>
    <name>C6X5W5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01355"/>
    <dbReference type="EnsemblBacteria" id="ACU07803">
        <property type="protein sequence ID" value="ACU07803"/>
        <property type="gene ID" value="FIC_01355"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01355"/>
    <dbReference type="eggNOG" id="ENOG502Z7JA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089286_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025636">
        <property type="entry name" value="DUF4294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14127">
        <property type="entry name" value="DUF4294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="243" mass="28715" checksum="4A5C2C1EE80F9712" modified="2009-09-22" version="1">MILYDVKIMNFNKLAAVILVFSSLQIYAQQDTVLIAKPISQYPPELLKTDELGNKYYYDEAQKAKIYEIEGENVIVMDELILLNKPRFNNQLDQNYYFFLNKKLNRVYPLFLTALEQYQDIQDELKTLDRSAQKKYVGSRQKQLADQYEVQLRDLTTTEGKVFAKLMNRATGKTVYEIIKELRGGWSAFWWNVKGNVADIELKEPYDPYRNRSDEFLESLLQSNWNAGYFLPYPGYRDFKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W7</accession>
    <name>C6X5W7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">FIC_01357</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806090.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01357"/>
    <dbReference type="EnsemblBacteria" id="ACU07805">
        <property type="protein sequence ID" value="ACU07805"/>
        <property type="gene ID" value="FIC_01357"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01357"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_10"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU07805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="216" mass="23792" checksum="7287052A71ECEC90" modified="2009-09-22" version="1">MKTKLIAPSLLSADFGNLQRDIEMLNRSQADWLHIDVMDGRFVPNISFGFPVMKAVQQHSKKFVDVHLMIVEPEKYVEEFIRMGADLISVHYEACTHLHRTISLIQESGAKAGVVLNPSTPVLMLEDIIADVDLVLLMSVNPGFGGQKFINNTYKKIAETKDLILSNNSTALIEVDGGVNLENAGKLFEAGADVLVAGNAVFSSENPERTIELLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W8</accession>
    <name>C6X5W8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pathogenesis-related protein 1B (PR-1B)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806091.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01358"/>
    <dbReference type="EnsemblBacteria" id="ACU07806">
        <property type="protein sequence ID" value="ACU07806"/>
        <property type="gene ID" value="FIC_01358"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01358"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843993_0_0_10"/>
    <dbReference type="OrthoDB" id="1705869at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="PTHR10334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973494" evidence="1">
        <location>
            <begin position="19"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="185"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="329" mass="36094" checksum="7A89D3E96508D052" modified="2009-09-22" version="1">MKTLILTLLICLFSGTQAQTKFWLSGNYSNGSMKYLNNGKAENIAVSWDKGAARSNSYVVLHGDFRRDAQGKETFFVDSESPKVNLYSGIVNRQKFNCPLNALEGKLTISSDGKSIDFASAVSLKDKANITVTKAELGTKFCDGKRYRVYYIKEIKEFVMPLGSNSTPTNSTNSSAATGSSLTSAEAEAALAFHNKARADVGVNPLNWSSKLSEYAQNWANHLVVQGKCNLEHRPDSGEWKSMYGENIAMLVPARNAASEASKLWYDEIKDYKHEVLNNSNWAVAGHYTQMVWHSTQSVGIGAAKCANGYTIVVANYDPSGNMIGQKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y0</accession>
    <name>C6X5Y0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium and cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806103.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01370"/>
    <dbReference type="EnsemblBacteria" id="ACU07818">
        <property type="protein sequence ID" value="ACU07818"/>
        <property type="gene ID" value="FIC_01370"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01370"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_10"/>
    <dbReference type="OMA" id="MVSVRIF"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="300" mass="35104" checksum="44223885C08E17E0" modified="2009-09-22" version="1">MPIELIFRNHHCEWLDVEAPTQQDLDFLHEKYGINSLLLEDTIDPNHLPKFEQDRSVKFFLMRENTELERTNLNTLSDISTKLGIFLIRNVIITVHRMKNRSIYELKKEILLPECADATPDKIALILALKVMKSFDDESKSLLETMDNIENEIFLKNTGNSNHIRRLYQLKRKSGLNTRILHISGGFIDHFKDLKINDTEFTDLKDKHDDVITDFEHLTAQATNLISMFLAMSDQRANQVMKVLAIYSMYFFPITFIAGIYGMNFDNMPELHHPLGYFLTLGLMAFIALITFVYVRRKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X630</accession>
    <name>C6X630_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M23/M37 peptidase/aminotransferase, class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806153.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01420"/>
    <dbReference type="EnsemblBacteria" id="ACU07868">
        <property type="protein sequence ID" value="ACU07868"/>
        <property type="gene ID" value="FIC_01420"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01420"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104232_0_0_10"/>
    <dbReference type="OMA" id="GDYPGVC"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="92"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="226" mass="25521" checksum="1B803309D7C57FD5" modified="2009-09-22" version="1">MTTFNDILQKQTAVKVIDASIDYKDYVAFDLSAQHTDELNLDLTDAEKFEEFVENHLSVNHAKVAFGGYLEKRNLYKRSTNFNDENSEERNIHIGLDLWIKAGTAVVSALDGTIHSFQNNTFFGDYGPTVIVEHEIECFTFYTLYGHLSLESLNGKKVGQPVKKGEKIAELGKPPVNGDYAPHLHFQIIKDIENKKGDYPGVCSISELDFYRENCPDPNLLLKIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X642</accession>
    <name>C6X642_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2384 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01432"/>
    <dbReference type="EnsemblBacteria" id="ACU07880">
        <property type="protein sequence ID" value="ACU07880"/>
        <property type="gene ID" value="FIC_01432"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01432"/>
    <dbReference type="eggNOG" id="COG5642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109353_4_3_10"/>
    <dbReference type="OMA" id="RIQYNVY"/>
    <dbReference type="OrthoDB" id="1850771at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024467">
        <property type="entry name" value="Xre/MbcA/ParS-like_toxin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09722">
        <property type="entry name" value="DUF2384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2384" evidence="1">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="159" mass="18221" checksum="5F1BA2AC5E3177E8" modified="2009-09-22" version="1">MMATNNRKQMPIPAKKTVVKDAAAAYGRPILQNFIMKDDYSLVKKAREGIDTKIFYSLAEQIKMPEKTLASVINLSPRTISNYREQNKDLDANYSEHLLKIINLYHLGQEIFGSLDEFTFWLQRPFYNSTEKPMDLMKTVGGVDLIAQEVEKLAQGYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X663</accession>
    <name>C6X663_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Possible POT family proton (H+)-dependent oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806186.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01453"/>
    <dbReference type="EnsemblBacteria" id="ACU07901">
        <property type="protein sequence ID" value="ACU07901"/>
        <property type="gene ID" value="FIC_01453"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01453"/>
    <dbReference type="eggNOG" id="COG3104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_0_2_10"/>
    <dbReference type="OMA" id="GMMMGLW"/>
    <dbReference type="OrthoDB" id="470322at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="503" mass="56051" checksum="B599A46863F3460F" modified="2009-09-22" version="1">MNLTLEQIQDFKGKYPRQIWSLFFSEMWERFCFYGMRGMLVFFMISELKFDDEKANLQYGATQAFVYAFTFVGGLFADKILGFRKSLFWGGLLMIVGSLILATNPHDFFFLGISFTVVGTGFFKPNISTMVGKLYSGDDSRRDAGFSLFYAGINLGALLGGYLCIAIGKGEMLSNLIPEDKRWNVAFGLAAIVMVISLINFVFTQRRLGPIGLMPQKISFDGRVIPTEKWKIYGVYALTLAFVPLIMIMVSVPQYTDYFMITVGPLTLIYLFYEMTKVSSSERKKLWAALVFIIFSIIFWGIYEQSGGSLSIFAANNLNKDLLGLDPNGVNNSGGAFFIIFLAPIFGLIWIWLSKKRLEPNTLIKFGLGFIFLGLGYYVLFATRFFADLQGITSLNIFTIALLVITFGELCLSPIGLSIMTKLSTEKLQGMMMGLWFLASAYGQYVAGIIGANMATAKEGSSNMDALLAYTEGYKQLGIYAVVAGLVLIAISPLVKKLMQDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X670</accession>
    <name>C6X670_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806193.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01460"/>
    <dbReference type="EnsemblBacteria" id="ACU07908">
        <property type="protein sequence ID" value="ACU07908"/>
        <property type="gene ID" value="FIC_01460"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01460"/>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041394_0_0_10"/>
    <dbReference type="OMA" id="LTFYSAY"/>
    <dbReference type="OrthoDB" id="1194226at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="361" mass="40687" checksum="F6E3AA16CAAE3664" modified="2009-09-22" version="1">MKAVLRIILALIFIASGFVKAVDVVGFSFKLQEYFSPAVFNLPLFESIALSIAIIVVGLELILGFMLLLTIRLKFTLSALIALCVFFAFLTFYSAYFNKVTDCGCFGDAIKFTPWQSFIKDIVLLLGLLVLWFLYRTKFGLLQPKRPAKFIALSVFTAAMVLITLHGILHEPLIDFRDYKIGTDLNAEKANIEKNPSEYKTFYSLKNEKTGEILEVNQDQYVSDKKYWDEGSPWKIEDGKTTSKIIKQGYESEISKFKPETPEGTDHTLEILKAPKAVLVFSYDPKNADSEILAETEAKLAAQKDTFVLGISTDPRTFKTIKNALMDGTAIKTIARSNPFVLILERGRIIDKMSADDYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X671</accession>
    <name>C6X671_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806194.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01461"/>
    <dbReference type="EnsemblBacteria" id="ACU07909">
        <property type="protein sequence ID" value="ACU07909"/>
        <property type="gene ID" value="FIC_01461"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01461"/>
    <dbReference type="eggNOG" id="ENOG5032KNH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2104217_0_0_10"/>
    <dbReference type="OMA" id="SIAGYHL"/>
    <dbReference type="OrthoDB" id="1744197at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="116" mass="13738" checksum="56730B910E13A217" modified="2009-09-22" version="1">MKKSNKSIAGYHLLMLLSSVDGEFSPEEGLKFQEFLADEFPFKIDLDDELDIIATLHPEDWKNHFEFHAQCFYDDSTEDERKSFLEFAKSLIKADEAVTDKEHDYYTMLKKMWKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X674</accession>
    <name>C6X674_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ordered locus">FIC_01464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806197.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01464"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="ACU07912">
        <property type="protein sequence ID" value="ACU07912"/>
        <property type="gene ID" value="FIC_01464"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01464"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_1_10"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="228" mass="25385" checksum="CEA1037B3221D6C5" modified="2009-09-22" version="1">MDIKKDFRDFSVKHLGNSGLATDQYMGMYGPTNLTPYIMEERRLNVAQMDVFSRLMMDRIIFLGTGIDDQVANIVTAQLLFLESSDASKDIQIYINSPGGSVYAGLGIYDTMQIIKPDVSTICTGMAASMGAVLLVAGEKGKRSALKHSRVMIHQPSGGAQGVASDMEINLREMLKLKKELYDIISIHSGQTYEWVEKASDRDYWMTSSEAKEYGMVDEVLERKTDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X677</accession>
    <name>C6X677_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806200.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01467"/>
    <dbReference type="EnsemblBacteria" id="ACU07915">
        <property type="protein sequence ID" value="ACU07915"/>
        <property type="gene ID" value="FIC_01467"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01467"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_5_0_10"/>
    <dbReference type="OMA" id="RIWILEG"/>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="135" mass="15465" checksum="DD6E077ADBFC44A1" modified="2009-09-22" version="1">MNFQINTLESWQSVVDQILPELQHNILLLKGNLGAGKTTFTKFLLKNIGSTDDVSSPTYAIVNEYNSPKGKIYHFDLYRMNSIEEVYDIGIEEYLDNAFLCIIEWPEIYETELTGLPHHEISITTDSDVRTVTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X682</accession>
    <name>C6X682_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinone biosynthesis monooxygenase UbiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806205.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01472"/>
    <dbReference type="EnsemblBacteria" id="ACU07920">
        <property type="protein sequence ID" value="ACU07920"/>
        <property type="gene ID" value="FIC_01472"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01472"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_10"/>
    <dbReference type="OMA" id="RRDYKRV"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="557" mass="63358" checksum="461E0D7CA51BDA41" modified="2009-09-22" version="1">MATIPEKFNNYSKFISFIYKYWNSDVFKTASENALNNTPDHDTAEDYPSYQEPEELAEDLKKMGPTYVKLGQLLSTRPDLMPEPYIKALESLQDDVEAIPYTIIQQIVEEETGQRISKAFESFDEEPLASASIGQVHRAVLRSGKHVAVKIQRPGIRKKFLEDLDTLKEMTDFAVKLNQTAKKYAVDYVLDELRFILLNELDYIKEAENLRALGKNLEDYTRIFVPQPIDGYTTSKILTMEYVDGKKVTSVSPLSRTEYDYTPLVDELVAVYMKQIIIDGFAHADPHPGNVHLTKDHKLALMDLGMVAKFGPELREYILKLMIAISKYNGAEVAKVLLQMSEYEKDADLQNFQKEINRLVMEAQNKTANDMQTARMLIQMNRVAADNGIKLAVELNIFGKILMNMDQIVAVLAPNYDLQKAIERNVESMMQKKVLNELKPEHFFTQLLEAKKLAERLPERLNIISERMANNEFEIKIDAIDEQRLTDGFQKVANRISIGLIIAALIIGAALLMKVPTSFTVLGYPGLAMIFFCAAAVFGVWLVLKMILNDEELKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I0</accession>
    <name>C6X6I0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, short-chain specific</fullName>
            <ecNumber evidence="9">1.3.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806303.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01571"/>
    <dbReference type="EnsemblBacteria" id="ACU08018">
        <property type="protein sequence ID" value="ACU08018"/>
        <property type="gene ID" value="FIC_01571"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01571"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_10"/>
    <dbReference type="OMA" id="NMATWML"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004085">
        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="379" mass="41170" checksum="E1297EFBAB9ADFEC" modified="2009-09-22" version="1">MDFNLTEEQVMIQQAARDFAQTELLPGVIERDNAQKFPHEQVKKMGELGFLGMMVDPKYGGAGMDSISYVLAIEEIAKVDASAAVVMSVNNSLVCAGLEKYCTEDQKMKYLKPLASGEVIGAFALSEPEAGSDATSQQTTAIDKGDHYLLNGTKNWITNGGNATYYIVIAQTDPEKKHKGINAFIVEKGWEGFEIGPKEDKLGIRGSDTHSLLFTDVKVPKENRIGDDGFGFAFAMGVLGGGRVGIASQALGIASGAYELALKYAKTRKAFKTEIINHQAIAFKLADMATNIMAARMLCYKAAVDKDAGKDIAEIGAMAKLYASQVAMDTTIEAVQIHGGYGYVKEYHVERMMRDAKITQIYEGTSEIQKIVISRSIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I4</accession>
    <name>C6X6I4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806307.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01575"/>
    <dbReference type="EnsemblBacteria" id="ACU08022">
        <property type="protein sequence ID" value="ACU08022"/>
        <property type="gene ID" value="FIC_01575"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01575"/>
    <dbReference type="eggNOG" id="ENOG5033A64">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675299_0_0_10"/>
    <dbReference type="OrthoDB" id="2197291at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="157" mass="18271" checksum="36FDC558D1E3B6E2" modified="2009-09-22" version="1">MIKVFLILLLSLISCNTEYKTFYNLHELKPKTFETESSKGNTNLIHIYSFDNNILDRRIKGFKSLTYSTLTSERVYIATETKNRKKYIASPSKRKHFEEFDFILDQYLKGNTEYLKTLVNSFSGAEIGSNFYLFDFRTNKVLEIAAIGFDSDGKLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD2</accession>
    <name>C6WZD2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782122.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00517"/>
    <dbReference type="EnsemblBacteria" id="ACU06975">
        <property type="protein sequence ID" value="ACU06975"/>
        <property type="gene ID" value="FIC_00517"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00517"/>
    <dbReference type="eggNOG" id="COG3027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164748_2_0_10"/>
    <dbReference type="OMA" id="QDVLAMC"/>
    <dbReference type="OrthoDB" id="1802106at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="95" mass="10719" checksum="EE79D86570A224CA" modified="2009-09-22" version="1">MEVRRITINIAGRNYPLNVPAAEEETLRKVGKQIEGMIKDFEQNFDVRDKQDALAMCALKLGTNAEVSVLSNEKNIIAANERLTYINQLLEAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH2</accession>
    <name>C6WZH2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MG(2+) chelatase family protein / ComM-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781654.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00029"/>
    <dbReference type="EnsemblBacteria" id="ACU06507">
        <property type="protein sequence ID" value="ACU06507"/>
        <property type="gene ID" value="FIC_00029"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00029"/>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_10"/>
    <dbReference type="OMA" id="STNPCPC"/>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="214"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="511" mass="56869" checksum="2A016EF3D2D1F5E4" modified="2009-09-22" version="1">MLVKIYGSAIFGVSAQTITIEVNVDTSGVGYHLVGLADNAIKESSYRISAALKNVGFKIPGKKITINMAPADLRKEGSAYDLSIALGILAASDQIKAENIGRYIIMGELSLDGGLLPIKGVLPIAIKAREEGFKGIILPKQNIREAAIVDQLEVYGIENIKEVIDYFNEDIPLERTTIDTRKEFQDRINFFPTDFSEVKGQETAKRAMEVAAAGGHNIILIGPPGSGKTMLAKRVPSILPPLTLKEALETTKIHSVAGKIGTETSLMTVRPFRSPHHTISDVALVGGGSYPQPGEISLAHNGVLFLDEMPEFKRTVLEVMRQPLEDREVTISRAKFTVNYPASFMLVASMNPSPSGYFPDDPNNTSSQFEMQRYMNKLSGPLLDRIDIHIEVQKVEFEQLSDKRKGERSDEIRNRVLKAREIQTERYRDSDIHYNAQMGPKDIEKHCDLDEASQNLIKTAMEKLNLSARAYDRILKVARTIADLENAERLSSVHIAEAIQYRSLDREFWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZS0</accession>
    <name>C6WZS0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781752.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00130"/>
    <dbReference type="EnsemblBacteria" id="ACU06605">
        <property type="protein sequence ID" value="ACU06605"/>
        <property type="gene ID" value="FIC_00130"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00130"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023843_0_1_10"/>
    <dbReference type="OMA" id="IVFEWGM"/>
    <dbReference type="OrthoDB" id="1201303at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="343"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="588"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="716" mass="79182" checksum="60FC64AA45E6A372" modified="2009-09-22" version="1">MAILGQIRNRPWLLMGIIAVAMLAFVVNPDSLEQLFGAKPGVYGKVNGEEITKEEYDDQLFMLQQQAQQQGQPATGLDEQAWQMMVQSKLIKQQFDKMGLTLTEDMFWNQLQFDPMFAQNQENFDAKGNFKGQEIKKQIAELQTSGNVEMYNNWLRTRRTIEYRMMARQVFANVSTGITASKKEAEEMMKQRDQVANIDFVKIDYNSYAQKNPVKVTTQDLADYIKKHPILFKRDASRNIGLVYFPAAASPQDEAVTQAEINKLFAQGTEMSGGKENFQNTTNDSMFVSLNSDLPFNPQYFSAEQLPVSIKDKVAAASVGTTFGPYKEQNFYVVSKLLDKKPSDSTLSRHILVSYKGNQAGGNETRSKEEAKKLADSIGAVLKSAPQKFTEFLKYSADPGSAGQGGSVGWTTPATPFVPQYLSFLANNGKGATGVVETDYGYHIINIEDKKTGAMTYKVANLVKTIKASDKTENEVYTKATRFIQQVQGKSFNDFSNLAKKGNYQFFNPKEIGRFSGQLPGLGTDKDQDIIAWAFHKKRSKGDTEIFTVDGTGDRIVAYVNGIQDAGTADPEAVRDQIEPIIKNKILAKRIVEKINTTKASSLDQIAKAFGSTKMSGQVNMLSPQVAGAMEPKVAGAAFGVAKGKLSMPVEGMTGVYVLVKNSETINKQPGDIKQVTQAIAGQNSQQFGQALLKSLQDNADIEDFRIELFNQTSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZX1</accession>
    <name>C6WZX1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00181"/>
    <dbReference type="EnsemblBacteria" id="ACU06656">
        <property type="protein sequence ID" value="ACU06656"/>
        <property type="gene ID" value="FIC_00181"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00181"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028525_0_0_10"/>
    <dbReference type="OMA" id="HINIEIV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="7TMR-DISM_7TM" evidence="3">
        <location>
            <begin position="51"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="312"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="516" mass="59340" checksum="31B70EE028E1E855" modified="2009-09-22" version="1">MALFDKGKHLTFRVSVRIVRVNFSTFEKNTILLMKNLFQTMIEHDTYGGILYLVLGGLILLSLFHLAMYFQNRERSYLLYSAYCFFSFLAYIPLVEGGIVATFSPLLGFNDHTKILFTIVFNCIYFFFFAEFLNIKLHKPAWYRIMVYPAGALLIMGILAFVTQIYFGTNHLYIFKNLFTLLITVHTALCFYLLTKLKNNLKYYIIFGGLVLFVCSVIGIHFIRELPFINITRKMGDFIYFGGLLIENLAFSLALGHRQKITFINKVSYQKGLVIQLKKNEMLKDQVNIENEKRLTAENEKFKYLQEISDLKLSVLQSQMNPHFIFNALNSIRYCILENDSQNALNYLTKFSKIMRTILTASKMKDFTLAEELHTLQLYVDIENLRFHEPIDFSIQIDQRINVDQVKLPPMVLQPYIENAILHGVSSVPDKKININISLQSGQVKICITDNGIGREEAGRLKTATENPAKSVGTDIARDMLKNYFGADRFAVEYEDVYNNGSPAGTKVHISIPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZY8</accession>
    <name>C6WZY8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781820.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00198"/>
    <dbReference type="EnsemblBacteria" id="ACU06673">
        <property type="protein sequence ID" value="ACU06673"/>
        <property type="gene ID" value="FIC_00198"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00198"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053320_3_0_10"/>
    <dbReference type="OMA" id="MSKMPAM"/>
    <dbReference type="OrthoDB" id="1548641at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973526" evidence="4">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="164" mass="18022" checksum="2BA8DFE13105F5C9" modified="2009-09-22" version="1">MKKLSVLFAAVMMLVTVGNANAQKIASIDYESVLAAMPETKKMTADLDTFSKTKGDELNKQAEAFQKEVQQYQAEGAKMTEAQRTAKEGELQKRQQNLQQLQQTAQQDLAQRRDAAVKPIIDKLNNAVTKVAKANSFDFIIDSTALIYKGGADATPLVKKELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ2</accession>
    <name>C6WZZ2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00202"/>
    <dbReference type="EnsemblBacteria" id="ACU06677">
        <property type="protein sequence ID" value="ACU06677"/>
        <property type="gene ID" value="FIC_00202"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00202"/>
    <dbReference type="HOGENOM" id="CLU_3356315_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="36" mass="4257" checksum="9ACC595D8F696CA4" modified="2009-09-22" version="1">MRRPQTAAKKDFHCNPGYNFRHFVLTRHVSSLKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ5</accession>
    <name>C6WZZ5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00206"/>
    <dbReference type="EnsemblBacteria" id="ACU06680">
        <property type="protein sequence ID" value="ACU06680"/>
        <property type="gene ID" value="FIC_00206"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00206"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_10"/>
    <dbReference type="OMA" id="RVMHDLR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="66"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="383"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="417"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="600" mass="68186" checksum="23D677D3843730F6" modified="2009-09-22" version="1">MRAKITFFCKRAGALAIVWACLTCIKFHFITFADHGAGEKQAQEHLFMNALKTLNPYFYKHRILLFWGFLFIIASNFFSIYKVQFVGRSVDEIANTTNLGFNRQVLIYVGIIVVSSILTGFFTFMMRQTIIVASRRIEYELKNKIYSHYQDLSLTDFKKTTTGDLMNRLSEDVVAVRMYLGPGVMYVVNLLILLIITSVYMLKTDVSMTIWSLVPLPILSFVIYKVSSIINQKSKIMQKSQSAISTFVQDSFSGIRVVKFFAKEKYIEKNYGTKVKDYQDKALDLAKTEAYFFTIILFVIGILNVIILLVGGQKYLNNELSVGKIADFFLYINILIWPFSMVGWVTSVNQRADASMARINEFLDMKTDIINTNHDIYPIEGNIEFRNVSYVYPNTGIKALDNLSFSIEAGKSLAIMGKTGSGKSTIALLLCRLIDPTEGEILVDGKNLKDHNLQNYRKYIGYIPQESFLFSDTIEHNIGFSIDNPTLEKVTEYAKKADVHKNIVEFKEQYKTLVGERGVMLSGGQKQRICIARALIKDPSILIFDDALSALDTETEENILQNIENEIQKSTSIIITHRESSAKRADKILNLTAIETDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ7</accession>
    <name>C6WZZ7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781829.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00208"/>
    <dbReference type="EnsemblBacteria" id="ACU06682">
        <property type="protein sequence ID" value="ACU06682"/>
        <property type="gene ID" value="FIC_00208"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00208"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122784_0_0_10"/>
    <dbReference type="OMA" id="KSTCGCT"/>
    <dbReference type="OrthoDB" id="1046637at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="164" mass="17170" checksum="444802FA7C0AC0C4" modified="2009-09-22" version="1">MKNLVKLLPVVAVLSLASCKKDQSADQLVTTEEAVVVDQPTADATVPTVDGATAQAVSGPLTTLALSESAFAFGKVKKGEQVEHVYEVTNTGTNPLIISQVKPGCGCTVPDYTKDPILPGQKGKITLKFDSGQFDGLVNKQAEVFANVEKAPVIIGFSADVQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X019</accession>
    <name>C6X019_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00230"/>
    <dbReference type="EnsemblBacteria" id="ACU06704">
        <property type="protein sequence ID" value="ACU06704"/>
        <property type="gene ID" value="FIC_00230"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00230"/>
    <dbReference type="HOGENOM" id="CLU_3373895_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="34" mass="3998" checksum="A664AA891F2FCF65" modified="2009-09-22" version="1">MGSIKIKKYIAELVKFQVNILSVMNDIWHIRVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X041</accession>
    <name>C6X041_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ser/Thr and Tyr protein phosphatase (Dual specificity)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781873.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00253"/>
    <dbReference type="EnsemblBacteria" id="ACU06726">
        <property type="protein sequence ID" value="ACU06726"/>
        <property type="gene ID" value="FIC_00253"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00253"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080647_1_0_10"/>
    <dbReference type="OMA" id="MEWERNI"/>
    <dbReference type="OrthoDB" id="1332843at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="6">
        <location>
            <begin position="83"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="271" mass="31248" checksum="BFB48000DABDF8DA" modified="2009-09-22" version="1">MKKMDSKVWALVIFSGAFAVIYKFSLWYAAGLGNVSSFVFSFEKNIPFIPWTIIPYLSSGVFFCVIFFIIRSEERLRVFLKRVLLMTALAGIGFIAMPLQYSYPRPEVSNPILNSLFWLLDGFDDPYNQSPSLHVAFAFAFWTVFRKLKAKWKPFAAVWLILVALSTLTTYQHHLIDVFAGSMLAHFTFIVFPSQQRSFGFRNLHAANLCFFAGWSTVTASFLLAEFYGSEWLNFNIVALIMFAVGYFYQRDMIGFVRREAVRISVFKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X084</accession>
    <name>C6X084_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781916.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00302"/>
    <dbReference type="EnsemblBacteria" id="ACU06769">
        <property type="protein sequence ID" value="ACU06769"/>
        <property type="gene ID" value="FIC_00302"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00302"/>
    <dbReference type="eggNOG" id="ENOG50332IT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145905_0_0_10"/>
    <dbReference type="OMA" id="CTNPEEW"/>
    <dbReference type="OrthoDB" id="2058305at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972162" evidence="1">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="151" mass="16171" checksum="0C04DD6B65283AA3" modified="2009-09-22" version="1">MKNLVIILAAVVSLSSCKSKNAADTANLPKDISLKPENNVAQNKEREMLSAMIQDIESSIGTQTCSDASQWAFAAIGSKPCGGPSSYIAYPKAMEDEILAKIDDFTRAQAAFNTKYQLMSDCRMVMPPSGIQCVDGKAVLINASSEMGEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B9</accession>
    <name>C6X0B9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hexapeptide transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781951.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00337"/>
    <dbReference type="EnsemblBacteria" id="ACU06804">
        <property type="protein sequence ID" value="ACU06804"/>
        <property type="gene ID" value="FIC_00337"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00337"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081811_2_0_10"/>
    <dbReference type="OMA" id="TIGHDCI"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="214" mass="23068" checksum="B3964C0B2D8D42B3" modified="2009-09-22" version="1">MIIVGAKGFAKELLEIQHQTNKLHNLCFYDDWNEEGPEMLHGTFPVLKKERAAKAYFQNIDRYFALGIGNPNLRFALFEKFIALGGLCQSTISTMAEIGHYGVTIGAGCNILSGVKISNDVRIGIGTMIYYNSVVTHDAYIGNFCEISPNVTLLGRCSIGDFVQIGTGAIIFPDVVIGNNTVIAAGAVVRTSMPASVLVAGVPAVIKKQLIQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E1</accession>
    <name>C6X0E1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781973.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00359"/>
    <dbReference type="EnsemblBacteria" id="ACU06826">
        <property type="protein sequence ID" value="ACU06826"/>
        <property type="gene ID" value="FIC_00359"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00359"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_101_4_10"/>
    <dbReference type="OMA" id="RKHEIAR"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="45"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="82"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="409" mass="45941" checksum="96E6C4FAFB0210EE" modified="2009-09-22" version="1">MNCNIAIKAVDISKQYRLGEVGTGTITHDLNRAWARLRGKEDPFLKIGESNDRATKGESDYVWSLKDINFEIEKGDAVGIIGRNGAGKSTLLKLLSRVTKPTTGHFEVQGRIASLLEVGTGFNPEMTGRENIFLNGAILGMRRHEIKRKFDEIVDFAGVERYIDTPVKRYSSGMYVRLAFAVAAHLESEILIVDEVLAVGDAEFQKKCLGKMGDVSKGEGRTVLFVSHNMAAVKNLCNHGILLENGNIDCIGNIDKVVNNYLYLSKNDAKSNFYAKDNQVLKSVEIITDFANIKIGESLRIKFDLNCISPTTQIHLGIHDLENLKISHLTTEYFADLKLRQNSITCVLPKLNLTEGDYYINVLIKDKSVNERYENCLQFHVSSGSYYVDKIPVVRQYSSILMDHFWCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L4</accession>
    <name>C6X0L4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00438"/>
    <dbReference type="EnsemblBacteria" id="ACU06900">
        <property type="protein sequence ID" value="ACU06900"/>
        <property type="gene ID" value="FIC_00438"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00438"/>
    <dbReference type="eggNOG" id="COG3590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_7_2_10"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973546" evidence="8">
        <location>
            <begin position="30"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13_N" evidence="10">
        <location>
            <begin position="64"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="9">
        <location>
            <begin position="495"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU06900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="700" mass="78386" checksum="450CA934B7A1556F" modified="2009-09-22" version="1">MKLFMKRVTISALAFSGIVLLHSCGTANTADQSATENQTVATETKAAPAEEGLNLDYMDTAVRPQDDFFSYVNGNWVKTAEIPSDKASWGSFNALREDVDVASLEILNKILSDQFSAGSEGQKIQALYGTFMNWDKRNADGINPIKADLAKIDQLKTIADLQKYLIEATKTGDNPLYAWRVGADLKNSKMNAVYFGGPSLGLGRDYYQKESESNTATLAEYKNYLAQLYTVLGYKNADQTAQRVVAFEKQLAKDLLNNEQNRDANLRYNPKNVSELPALVKSINLPNYLSAVGVNTDKVIVSEIKYLQNMDSWMNARTLPLIKEYLKARMVAGNATNLNQQLDDINFNFYSKYLQGQKEQRSMDKRGLGIVNGTLGEAFGKLYVEKYFPAGAKEQMETYISYIKKGFEHHIANLDWMSPETKVKAQEKLSKFSVKIAYPDTWKDYSKLQLASDADGGSYYTNLQKVTEWQYAKNLDKVGKPVDKTEWGMAPQTVNAYYSGSNNEIVFPAAILQPPFFNFKADPAVNFGGIGAVIGHEISHGFDDSGSRFDGDGNLNNWWTDADRKNFDGKVGQLADQYSKYEPVKGSFINGKFTSGENIGDLGGVAVAYTALQMYLKDHGDPGLISGFNQDQRFFMSWATVWRTKSTEQYMVNQVKTDPHSPGYFRAFGPLVNQDSFYKAFDVKPGDKLYKAPEERVKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0M4</accession>
    <name>C6X0M4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00448"/>
    <dbReference type="EnsemblBacteria" id="ACU06910">
        <property type="protein sequence ID" value="ACU06910"/>
        <property type="gene ID" value="FIC_00448"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00448"/>
    <dbReference type="eggNOG" id="ENOG5032YSV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180763_0_0_10"/>
    <dbReference type="OMA" id="MQFTSEV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="109" mass="12191" checksum="DD20E3B3BDCAEA5A" modified="2009-09-22" version="1">MYYKVLSNFKTRIMMNTTQRNLAIYGLPAMLLSLPLIAMQFTREVNWTFSDFVIGGVLLFGTAGVIDLVLRTVKTRRNRIILCVSVLVVLFLVWAELAVGVFGTPFAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N9</accession>
    <name>C6X0N9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein HU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782072.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00463"/>
    <dbReference type="EnsemblBacteria" id="ACU06925">
        <property type="protein sequence ID" value="ACU06925"/>
        <property type="gene ID" value="FIC_00463"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00463"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_2_3_10"/>
    <dbReference type="OMA" id="IYVRGFG"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="10678" checksum="46B0FCA25C37604C" modified="2009-09-22" version="1">MTKAELVSTISNKLGTEKNETQKVVEAFMQEIRTSMYNGDNVYLRGFGSFVIKTRAAKTGRNISKNTAIEIPAHNIPAFKPSKTFVEKVKTKVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P0</accession>
    <name>C6X0P0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic axial filament protein CafA and Ribonuclease G</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782073.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00464"/>
    <dbReference type="EnsemblBacteria" id="ACU06926">
        <property type="protein sequence ID" value="ACU06926"/>
        <property type="gene ID" value="FIC_00464"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00464"/>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003468_5_3_10"/>
    <dbReference type="OMA" id="TKGPRIS"/>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1" evidence="6">
        <location>
            <begin position="37"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="519" mass="59598" checksum="00524F86A24AC3A3" modified="2009-09-22" version="1">MKKELIISHEAEKSKIALLEDGRLFELHEQEDKSDFVVGDLFIGKVKKLAPNLNAAFVSIGYEKDAFLHYQDLGPQYLTYKKFLKDTVSKKQQTTSLKNFEIQPEINKNGLIDKVLAKDDSVILQITKEPISTKGPRISTQISLTGRFLVLIPFDKSVSISKKIESAEERERLRTLIESIKPEGFGVIIRTVAEGKKVAELHNDMNQLVQKWDTAFKNLQKNKVPSRVLSEEDKASAILRDNFNSDFVSIICDDEQMVDDMKAYIEVIAPERKNIVQFYDKPVPLMEYYNVEKQLKQSFGKHVNIPSSKGAYLVIEHTEALHVIDVNSGNNISSGNSASREHALTVNKMAATEIARQLRLRDMGGIIVVDFIDMISADHRRELYDHLKNEMSRDKARHKILPPSKFGLIQLTRQRTRPENIIETKEENPNAAGEILAPIVVVERMEEVIRNIIQTEKGKIFLHAHPFVEAYLTKGFMSIQMKWYLKYKKWVTIIPRDSFKYLEYKLINAKKEELMSYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Q0</accession>
    <name>C6X0Q0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00474"/>
    <dbReference type="EnsemblBacteria" id="ACU06936">
        <property type="protein sequence ID" value="ACU06936"/>
        <property type="gene ID" value="FIC_00474"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00474"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094493_0_0_10"/>
    <dbReference type="OMA" id="LMPFENE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972184" evidence="1">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="2">
        <location>
            <begin position="74"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="264" mass="29476" checksum="17FE97C41E98878E" modified="2009-09-22" version="1">MQKQIFISMKHKFLLLVPALLLISACRTPLSIVQTETQKNISINADLPEDQRLKSVIEPYKKEVEAKMNTRISHTSVDLNKQGDNSNLGNLLADYTFEGADKWAKDNGIPGGVDAVVINIGGIRSTIGAGDILTRHVFEVMPFENEVIIVKMKGSDLSGLFDYYLKTQTNNPVSRLYIETDNGNLTKQLINGKEVVPTQFYYIATSDYLALGGDNMAFFGKGEMISTGIKLRELFLEKFKADPEIVPPVDIRLNFKNKKNRTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Q5</accession>
    <name>C6X0Q5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-associated heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782088.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00479"/>
    <dbReference type="EnsemblBacteria" id="ACU06941">
        <property type="protein sequence ID" value="ACU06941"/>
        <property type="gene ID" value="FIC_00479"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00479"/>
    <dbReference type="eggNOG" id="COG1188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101003_2_0_10"/>
    <dbReference type="OMA" id="IDKYLWC"/>
    <dbReference type="OrthoDB" id="2006597at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025708">
        <property type="entry name" value="HSP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="17385" checksum="EB6BF03C498EE42D" modified="2009-09-22" version="1">MRIDKFLWCVRFYKTRSIAAAEIKKNRISVGNNVAKSSKEVTLGDVIKIRKNQIDYQIKVLQIPKSRMGPKLVPLHIEDKTDKEQYEILKLRNLNQDYYRNRGEGRPTKKDRRSMDDFIDGDGGNNESDIADDSSWELFFSDVDDHSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S8</accession>
    <name>C6X0S8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhnB protein putative DNA binding 3-demethylubiquinone-9 3-methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806326.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01595"/>
    <dbReference type="EnsemblBacteria" id="ACU08041">
        <property type="protein sequence ID" value="ACU08041"/>
        <property type="gene ID" value="FIC_01595"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01595"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_17_2_10"/>
    <dbReference type="OMA" id="LEKQMWG"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="148" mass="16551" checksum="CCA96BCA2047E250" modified="2009-09-22" version="1">MAQINAYLTFNGNCGEAFRFYQEVFGTEFQNFSRFGDMPAEEGRQLPETDRDKIMHVALPISQETILMGSDTGEGYSARFVAGNNISLSVNTDSKEEADRIFNGLSAGGTVTMPLAETFWGAYFGMWTDKFGINWMVNYDDPTKVQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X7</accession>
    <name>C6X0X7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prmA</name>
        <name evidence="3" type="ordered locus">FIC_01645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806375.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01645"/>
    <dbReference type="EnsemblBacteria" id="ACU08090">
        <property type="protein sequence ID" value="ACU08090"/>
        <property type="gene ID" value="FIC_01645"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01645"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_0_0_10"/>
    <dbReference type="OMA" id="EFFFIFP"/>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="277" mass="31606" checksum="B145518F4DED3028" modified="2009-09-22" version="1">MNSYLEFNFKISPLQPWNEILMAELIEIGFDSFTEEHDGILGYIQKEQFNEDSLKEIGLMSHPDVQISYTFSEMPNINWNEEWEKNFDPINVENQVSIRAEFHENQNLPHEIIIQPKMSFGTGHHATTYLMIQQMLDMNFDSKTVLDMGCGTSVLAIFAKQKGAGKTVAIDIDEWSVENSKENAARNNVELEISQGTADNLGDEKYDIILANINRNILISDIPTYVSVMNEGGQLLLSGLCFFDVDDILEVCTAQNLKLKKQLQREEWVSLLMENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X131</accession>
    <name>C6X131_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806429.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01701"/>
    <dbReference type="EnsemblBacteria" id="ACU08144">
        <property type="protein sequence ID" value="ACU08144"/>
        <property type="gene ID" value="FIC_01701"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01701"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_19_1_10"/>
    <dbReference type="OMA" id="RFERWRP"/>
    <dbReference type="OrthoDB" id="1840839at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="354" mass="39810" checksum="3390CD4C9ABD4075" modified="2009-09-22" version="1">MKQIKVGLCAFGMSGKVFHAPFIKEHSGFSLTAIVERNREESKEKYPDAVIYQSVTEMLQNADVDLVVVNTPVQMHFDYVKASLEAGKNVIVEKPFTVSTAEAEELVRLAAEKNLFLSVYQNRRFDRDYLKVQKVIQSRKLGQIKETEIRFDRYRTEPSAKAHKENPELAGSGALHDLGSHLIDQATQLFGFPEKLFADVFSMKGEAFANDYFEILLYYKTGLRVRLKSSVFTREAHYAYAVHGSNGSFLQERTDNQESELVAGSAPVYGADWVKPLRDNDGILHFLNENSAEERSFTHSEPGNYMNYYQAIYDHLTDGSPLPSPGSEIIGNMKVIEATIESAKKGAVVSLNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X145</accession>
    <name>C6X145_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheB methylesterase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806443.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01715"/>
    <dbReference type="EnsemblBacteria" id="ACU08158">
        <property type="protein sequence ID" value="ACU08158"/>
        <property type="gene ID" value="FIC_01715"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01715"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_2_10"/>
    <dbReference type="OMA" id="PGYHLSV"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="186" mass="20063" checksum="AA7F28E5EED73A6F" modified="2009-09-22" version="1">MEHCEALIIGGSAGSLEVLLKVLPGLKETLSFPIIIVLHRKSGKDRILTDLLASKTVLNVSEATEKDKIEPATVYIAPPDYHLLIENDRTFSLDASEKVNFSRPSIDVTFENAAAVYGENVVCLLLSGANTDGTAGLKDVQISGGRVLVQDPETATVRYMPENALLHVAADAVLDPEHIADFINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X163</accession>
    <name>C6X163_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806461.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01733"/>
    <dbReference type="CAZy" id="GH10">
        <property type="family name" value="Glycoside Hydrolase Family 10"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08176">
        <property type="protein sequence ID" value="ACU08176"/>
        <property type="gene ID" value="FIC_01733"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01733"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_6_1_10"/>
    <dbReference type="OMA" id="PENQMKW"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="5">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="372" mass="42424" checksum="1C24CA01632D48CC" modified="2009-09-22" version="1">MNKSILIALFALVSCGVTQKSVSTEASLKDAFEDRFYIGTALNLNHIHGADTKGIDIVEKHFSSIVAENCMKSMFLQPQEGQFFFDDADKFVAFGEKNNQFIIGHTLIWHSQAPDWFFTDKDGNNVSAEVMKQRLKSHINTVVSRYKGRIQGWDVVNEAILEDGSYRKSKFYEILGEEFIPLAFQYAREADPEAELYYNDYNEWYPKKIETVTKLINDLRSSGIRIDGIGLQGHVGLDTPSIEEYEKTIVAYKNAGIKVSVTELEISALPSPWGTSANVADTVGYEAKMNPYTTGLPAEVQSRWEQRYIDFFSLFKKYQETVQRVTFWGVADGDSWKNDFPIVGRTDYPLLFDRNYQAKPVVKKLVELNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X196</accession>
    <name>C6X196_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01766"/>
    <dbReference type="EnsemblBacteria" id="ACU08209">
        <property type="protein sequence ID" value="ACU08209"/>
        <property type="gene ID" value="FIC_01766"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01766"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250893_0_0_10"/>
    <dbReference type="OMA" id="NTAICER"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1418" mass="156251" checksum="0BFAEFEDC7E01683" modified="2009-09-22" version="1">MSRAVFGKKSKIMNRIFIFLYLLLSGCFGLLSAQTCIPMDVKDVWGNDNVLIDCSYPLVNGECVSLTATAPSTRETSSYRVDPIHFEPYIPFNAGTPLNANYDDLFAEIIDIPFAFCFFGKNFNKLLIGSNGLVTFDASQLGKISYPNVEQTNPNPLLPGNSIFGVFQDLVFSNADSSEIYYSVINDGNCRKLVINFFEGRIAGCQDRSSTQIVLSEFTNEIEIFIDQKALPCATARFPNALLGITNANGTLGYSPPNRNTGVWEAQQEAWRFSPDGAVINPLIEWFDERNVRLGSGSTFNVCPKQNTRYSAKATYNMCGAPFTLTDTIDVTFAADFPLARNYTKVFCTSADGVENINLDDYRQFLTPQNPADLQFTYHNTLAEAQAGTNATPTTLVLNEERLIYVRIQHPQNTECFRVALLRFQFISAVIITDIVSVCDTNNDGVENNFPLSTFNAVLFAPGISGAVTYYLSEVDAQNGTNPVATATLRDGMRLWLKFATAQCSQVIGPVTVNFTPGPAVSTPIDLEITICDINDNDTEPYDFDLSVSGLISSDPNVTFSYYSSFQQAYSGAGAQINTIKEGNYSIYVRVEQPGGCFSVAEVRLKVEFTEIEAKNETEYICFNGTEDVTVDLSALSASMLLSPASGLTVSFHATEADAEEDVSPISPMQLITANGNSVSMRYFVRFAESPTCYTVRVITIVLIHPVAAKNNFNVCDFNNDATETFSLNQYTGPISGAQPATVSYFQSLQNAQDNSGALTSFTLTGSAQLFARIVVQGCVEIYPITFNLIPTPVVNPAVTITRRSFCDHNNDGGEAYDLTQHQSEIYAGSGSVVLSYFTGYNAANQSFSGPIADPKRFIATGSNTVYARVQFTTGGCFSVSTLQLNIDFIPAPVIKEATLRICDEQFNFNETFNLADAIPQMFDPAANSTALSDIKVTYYRTLAAANAGISSTAVSPTQLTLQSLVTFYARFEAKSTDCYSVKPIHLRTYFPPKAINSAVTGICDSNLDGLFELNLLQYTSQVVDFADPENTFTFYRTLSDAQSETNAIADPENFAVFPLPDRIYVKVQNIPGCNDISFITLQAGTKLQLIQPGPFPLDVCDTANDGQEVINLTQFESQMYPGAQFEYYPSLTDLNKARNQITGPATYTFNKSSNLSAFYAKVSFAGFCPVYAVINVNLKKTPQFSIEDHFFCPYNGDSVDIEPDFTGQDIVSYEWRNPAGEIVSTTKYLRDVNVTGMYSLLVTASNSCTFSTTFEVKHYEVPIITQLTANGSNYTVTATGSKTILYSIDGLTWQSGNIFYNLPTGQTTFYVKFADEDCIGLPKKGVILDIPNAFTPNEDGINDVWQVSGLDVFDGANSSIQIFDRQQVLVHQEEGPDRLSWNGRWMGRPVPTSTYWYVLRLPDGRIFYGWIFLKNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C4</accession>
    <name>C6X1C4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806522.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01794"/>
    <dbReference type="EnsemblBacteria" id="ACU08237">
        <property type="protein sequence ID" value="ACU08237"/>
        <property type="gene ID" value="FIC_01794"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01794"/>
    <dbReference type="eggNOG" id="COG4628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151208_2_0_10"/>
    <dbReference type="OMA" id="VNINCFK"/>
    <dbReference type="OrthoDB" id="1457473at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018668">
        <property type="entry name" value="DNA-binding_VF530-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09905">
        <property type="entry name" value="VF530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="84" mass="9811" checksum="0E775E44B2C0201A" modified="2009-09-22" version="1">MEEKSKDPLHGKRLDAILEELVDYYGGFEKLGEQINIKCFTDNPSISSSLKFLRKTDWARTKVESLYLYVLRQKKKAARKDDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D0</accession>
    <name>C6X1D0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2807 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806528.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01800"/>
    <dbReference type="EnsemblBacteria" id="ACU08243">
        <property type="protein sequence ID" value="ACU08243"/>
        <property type="gene ID" value="FIC_01800"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01800"/>
    <dbReference type="eggNOG" id="ENOG5031S92">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102881_0_0_10"/>
    <dbReference type="OMA" id="LKLRMPF"/>
    <dbReference type="OrthoDB" id="1303157at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972209" description="DUF2807 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2807" evidence="2">
        <location>
            <begin position="26"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="220" mass="23438" checksum="5C24F6CFBEDAD460" modified="2009-09-22" version="1">MKKVLGSFLLVAAQFALAQTARNVGEFSSLKVYDKIKVTLIQSDNSRVVLENDDPDVEIVNKNGELKIRMAPAKILQGNNTSVKVYYENLNDIQASQGSSVSSENELDSKMLTLVSNEGSVIELPVNTSKLNIKTNSAGEIKLTGIADNQDVIVNSGGKYFGETVESENTKVTANAGGVAVVTATGSVNATTRAGGIIDVFGDPEDRKVKNVIGGKINFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D4</accession>
    <name>C6X1D4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806532.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01804"/>
    <dbReference type="EnsemblBacteria" id="ACU08247">
        <property type="protein sequence ID" value="ACU08247"/>
        <property type="gene ID" value="FIC_01804"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01804"/>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_1_10"/>
    <dbReference type="OMA" id="VVDEWHE"/>
    <dbReference type="OrthoDB" id="35275at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026362">
        <property type="entry name" value="DEXH_lig_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04121">
        <property type="entry name" value="DEXH_lig_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="247"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="818" mass="92630" checksum="F4B72A709EF62450" modified="2009-09-22" version="1">MAGKFLESEGYGIVERWLAAKGFTPFSFQRETWEKFGRGYSGMVVAPTGFGKTYSVFLAVITDFLNRPGNYKDGLQLLWITPLRALAKDIAKAMTEAIDEIGLDWKVSVRNGDTPQAERVSQTKKMPEILIITPESLQLLLAQKNNQRFFKSLKCVAIDEWHELIGSKRGVLVELALSQILSYQNSIKIWGITATIGNLDEALEVLIPYDLKKTKVVAKEKKKIDIISIFPDEVEVLPWAGHLGAKLVDKVVPVILQSQTTLVFTNTRSQAEMWYQLLLKEYPDFAGQIAIHHSSIDRELRIWIEENLSSGYLKAVISTSSLDLGVDFKPVDTVIQIGSSKGVARFLQRAGRSGHSPFETSKIYFVPTHSLELIEVSALKEAVKQKVIEPRTPVVMSFDVLIQFLMTLAVGDGFDEKALFPRIKSTFAFSEITPDDWQSLLQFITVGGGALKNYEEYRKVSIENGIYKVTSRRIAMLHRMNIGVIVSDAMLKVKFLGGGYIGMIEEYFITRLKKEDKFILAGRVLEISHIKEMTVFVRNSKGKAMIPSYLGGRLPLTSHLSHFLRLKLSDSLQAKSSEKELKFLHPLLVSQQRNSHIPKDDEFLVELIETRDGHHLFMYPFEGRLIHEVMAALVAFRISKIMPISFSMAMNDYGFELLSSQEIPVTEEVLKKILTKDNLIQDVMSSVNATEMARRKFRDIAVISGMVVQNYPGIQKNNKSLQASSGLIFNVFEDYNPENLLFRQAYAEVFNQQIDEHRLMNAFKRIAKSKIILKFANAFTPLSFPIKVDSLRQSLTSEDLDSRILRLQKESMKRAINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F7</accession>
    <name>C6X1F7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806555.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01827"/>
    <dbReference type="EnsemblBacteria" id="ACU08270">
        <property type="protein sequence ID" value="ACU08270"/>
        <property type="gene ID" value="FIC_01827"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01827"/>
    <dbReference type="eggNOG" id="ENOG5032FC3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106179_0_0_10"/>
    <dbReference type="OMA" id="VKWIFII"/>
    <dbReference type="OrthoDB" id="1324838at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="224" mass="25954" checksum="ACC3AE943FD515FF" modified="2009-09-22" version="1">MPEFDIDSFKKTWQEHKVQPKYSSTEIEAMLNKSSRNYVKYILWISIAEFLLFLSVNIYYTFIGDDTQSFITVLGKLGVHSTLELEKDFAHLYFLLKVISLALTTIFVIKFYQNYRLINVESNLKKLILQIIRFKKTVNVFILANLVLLVVFTAVLTIFTFSVLASQNVHLNNPSLIGFVVGLVAVTLLSLLLIWLYYKLLYGILLRKLGRNLRELQKIDTEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I3</accession>
    <name>C6X1I3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BatA (Bacteroides aerotolerance operon)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806581.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01853"/>
    <dbReference type="EnsemblBacteria" id="ACU08296">
        <property type="protein sequence ID" value="ACU08296"/>
        <property type="gene ID" value="FIC_01853"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01853"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024570_0_0_10"/>
    <dbReference type="OMA" id="RYFRATD"/>
    <dbReference type="OrthoDB" id="736429at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="93"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="334" mass="37792" checksum="C46DD2EF2B0E059F" modified="2009-09-22" version="1">MKIDLLHFEFYSPWFLLLFLAFIPLAIIDMRKKKRRGIRVPSTQNMSENRGILFVLFLLKISKYILLSALIIAMARPRTFTISENNDDTKGIDIMMSVDVSLSMLARDLEPDRLTALKNIAKKFVDKRPGDRIGLVTYSGEAFTKVPVTSDHAVLLEELENLNPLELQPGTAIGEGLSVAVSHLRHSKAKSKIIILMTDGVNTIENAMPAQVGAQLAKSNDIRVYSIGIGTNGYALMPTQTDIFGDLVFTEVEVKIDEPVLREIAQTTGGKYFRATSNQSLEEVYEEINQLEKSELQSSKLYNYEEYFRIFLWIALGILLLDAVLRWVFYKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1K2</accession>
    <name>C6X1K2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806600.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01872"/>
    <dbReference type="EnsemblBacteria" id="ACU08315">
        <property type="protein sequence ID" value="ACU08315"/>
        <property type="gene ID" value="FIC_01872"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01872"/>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053817_0_0_10"/>
    <dbReference type="OMA" id="RYEGPGW"/>
    <dbReference type="OrthoDB" id="982403at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032342">
        <property type="entry name" value="DUF4861"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16153">
        <property type="entry name" value="DUF4861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973592" evidence="1">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="324" mass="36494" checksum="CA26E5F903CED903" modified="2009-09-22" version="1">MKFIPGILVLPALALLANCTTVNNASTAQNAKTYAEISIKEGGQWNGKKYEGGTFKNVQDLTLPSTHTDHSYYIRYEGPGWESNKVGYRLYLDWRNAIDIFGKLTEDMVLQEVGQDGFDSYHNMSDWGADILKVGKGLGIGSIGRVVNNELLHFNKVENTSARVENSNSNSKVFVNYKGWETNGESTDLSSELTIFPDQRYTRHTIQSSNALNGIVTGIVNLYKLPAIKKTSANQKWAYVASYGKQTLFDDNLGMAVFYRTEDAEKIFEGATDHLVQFRPTTKKITFYFLGAWEKEINGIKTEAEFLKYLDENLDKLNKTNQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L8</accession>
    <name>C6X1L8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxygluconate kinase</fullName>
            <ecNumber evidence="2">2.7.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.45" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806616.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01888"/>
    <dbReference type="EnsemblBacteria" id="ACU08331">
        <property type="protein sequence ID" value="ACU08331"/>
        <property type="gene ID" value="FIC_01888"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01888"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_10"/>
    <dbReference type="OMA" id="CIGIEPL"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008673">
        <property type="term" value="F:2-dehydro-3-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="346" mass="37856" checksum="46A50A4197DB9A55" modified="2009-09-22" version="1">MSRVVTFGEIMLRLAPQGYLRFSQADNFDVVYGGGESNVAVSLANYGIPVDFVTRLPKNDIGQCAMMEMRKRGVGVDKIVWGGDRLGIYFLETGAVSRGSKVVYDRAHSAMAEIQSGMVNWEEVFEGAEWFHWTGITPAISQSSADVCLEAVKAASKLGLTISTDLNYRAKLWKYGGDREKIMTELTSYCDIILGNEEDAEMHFGIKPEGAAVQTHGHDVKAEAFLSVCQQMMEKFPKAKKVITTLRGSISASHNTWAGVLYDGKEMLQTRQYQITDIVDRVGGGDSFMGGLIYGLLTYPDDDQNALDFAVAASCLKHTIKGDANLVTVDEVMKLMGGDASGRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M6</accession>
    <name>C6X1M6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloromuconate cycloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806624.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01897"/>
    <dbReference type="EnsemblBacteria" id="ACU08339">
        <property type="protein sequence ID" value="ACU08339"/>
        <property type="gene ID" value="FIC_01897"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01897"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_0_0_10"/>
    <dbReference type="OMA" id="INGLVWM"/>
    <dbReference type="OrthoDB" id="951991at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="335" mass="37496" checksum="3DFC0ED969C06CD1" modified="2009-09-22" version="1">MTARFYPYLLQFKRPGGTSRGVLHTKETFILEVFDGAEKGVGECGLFRGLSHDDVPEYEAKLQWLCENINAGYETLKAELKHFPSIWFGYQQAVLNLKNGENLYFPSAFASGESFIKINGLIWMGEAGFMQTQIEEKISEGFTCIKLKIGTDWPTEKKILQQLRNAFPQDQLELRVDANGAFDAEEALSVLDDLAKLKIHSIEQPIKAGNHSQMQQLCISTPTPIALDEELIGVVETADKRELLEKIKPQYIILKPSLAGGFSGSDEWISIAEDMGIGWWITSALESNIGLNAIAQYTFTKKSKIPQGLGTGGLFTNNFETELYLRGDRLWTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S3</accession>
    <name>C6X1S3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FdtA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806671.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01944"/>
    <dbReference type="EnsemblBacteria" id="ACU08386">
        <property type="protein sequence ID" value="ACU08386"/>
        <property type="gene ID" value="FIC_01944"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01944"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127501_0_0_10"/>
    <dbReference type="OMA" id="RSYWIYD"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd20292">
        <property type="entry name" value="cupin_QdtA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008894">
        <property type="entry name" value="QdtA_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05523">
        <property type="entry name" value="FdtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FdtA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="134" mass="15881" checksum="D786911ABC2B823A" modified="2009-09-22" version="1">MYQPIIIKLPKIVDPRGNLSFFENPKQLPFEIARTYWIYDVPGGETRGSHAFKEQQEFIVALSGSFDIVLHDGEKEEKFSLNRSYYGLYIPEMYWRRLENFSTNALALIVSDKQYHGDDYIRDFDDFKQLKNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S4</accession>
    <name>C6X1S4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Tyrosine-protein kinase wzc</fullName>
            <ecNumber evidence="19">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">FIC_01945</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="19"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01945"/>
    <dbReference type="EnsemblBacteria" id="ACU08387">
        <property type="protein sequence ID" value="ACU08387"/>
        <property type="gene ID" value="FIC_01945"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01945"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_6_0_10"/>
    <dbReference type="OMA" id="QQIYIQL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="16">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="18">
        <location>
            <begin position="447"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="17">
        <location>
            <begin position="588"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ACU08387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="791" mass="88358" checksum="EC87F008E60921C3" modified="2009-09-22" version="1">MHTSMSDVSNAEVKASEDISLNEIIKPYIRKWWWFILSVSACVALAVFYIKTATPVFNVKSTALIKDTKKTPAADMGMLSELGGFGSMGTNSIENEIEVLKSKKLMHDVVTELRLQTSLISKDGLKEKELYGKTAPVIVQIINEKLYDERIDEPLVLTIKGDRIEVASEELPKTIITTYKKTISLPYANIMILKNPAYEPDKKEKLGELHITYMPTTAAVNTYQKMVQVDLVNMDATVLELSINYPNKDKARNIINKLVQAYNNDAISDKNAESKKTKDFIDERVRIIASELGEVESQKEQFKVANKITDIPTEASLTLGSSASARARLLETDTQLQLTNDLIFYMSKLGSNQTLPSSVGLSNPTASANINSYNQLILERNNLLESATPQNPLVADLNKQISVLRSSVQDGLVKHRIGLEMARSQIAGEQNVINSKITRIPAQEKLFRSIERQQQIKENLYLLLLQKREEAAISLAITAPKARIIDAAYPSEKPVSPKKIIVLGAALLLGMLLPFGYIYLRELFNNKIRSKHDLEKLSHAPILGELPSVASGQSELVEVNDLSPMAEAFRIIITNMNFMIPRTEKGKTVFVSSSVKGEGKTFVSVNLALTLASGKNRVLIIGSDIRNPQLQRYNPARKGLIGLTEYLHDSQTSLQDIIHVSSFNPQCDVIYSGSIPPNPTELLSNGRYEQLIDAVKPMYDYVILDTAPLMLVTDTFLFAHMADATLYVTRSGYTEKGLIDFANKQIDAKKIKNVAFVLNDVNRDYFGYGNKYGYGYTVDNRTFFQKLKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1X9</accession>
    <name>C6X1X9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ordered locus">FIC_02000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806726.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02000"/>
    <dbReference type="EnsemblBacteria" id="ACU08442">
        <property type="protein sequence ID" value="ACU08442"/>
        <property type="gene ID" value="FIC_02000"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02000"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_10"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="71" mass="8179" checksum="F26C763B4FE8ACAD" modified="2009-09-22" version="1">MAKQKHIEQDGVITEALSNAQFRVELENGHILIAHISGKMRMHYIKLLPGDKVKLELSPYDLSKGRITFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X202</accession>
    <name>C6X202_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative iron-regulated transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02023"/>
    <dbReference type="EnsemblBacteria" id="ACU08465">
        <property type="protein sequence ID" value="ACU08465"/>
        <property type="gene ID" value="FIC_02023"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02023"/>
    <dbReference type="eggNOG" id="COG3182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031962_2_0_10"/>
    <dbReference type="OMA" id="QHTVYVD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="406" mass="46000" checksum="8AD2CFA2F7751CF6" modified="2009-09-22" version="1">MTFVHLMKTSPLKKTLLRKRRKKESLFKYIMGLLHLWLGLLSGIVIVVVCLSGCIYAFKNQFTDLLNRDKVYVEAVGTQKTPDQIQQMLAKDQKVLTGIFMPAQKDRSYVLNYSQNGIASSGYFNPYTGKNLGNADVSLNNFFEVILDIHKNLAMGNVGRQINGVAVLMFCILLFSGFILWFPKKLKHMRQALTVKFNAKFQRLNYDLHNTMGFYACILLFFMAVTGLYVTYPWVKNALIVSLGGTLVSNTAATNTGEEDNAFDDLFNDMLSRQKEKSSLKEEKAATLGQIIAAANKILPYEAATTVEYPNKENPRFVVTKINTDNWLGAMLPDQITFDKTGELKSKDLFQDKPLDQQFTSLAKPLHTGEILGLKSIILYFIVCFIGFSLPVTGFIFWFNRFRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X210</accession>
    <name>C6X210_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component regulator three Y domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806757.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02031"/>
    <dbReference type="EnsemblBacteria" id="ACU08473">
        <property type="protein sequence ID" value="ACU08473"/>
        <property type="gene ID" value="FIC_02031"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02031"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502269_0_0_10"/>
    <dbReference type="OMA" id="LEFRNEF"/>
    <dbReference type="OrthoDB" id="413399at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="374"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="542" mass="61333" checksum="F3B9E93FD03F9243" modified="2009-09-22" version="1">MKKTLFFLLFTQLFFSQQYTISNAERTALVNIYNATSGNEWSQTWDFEKDPRHWYGIKIQNGNVIEINLRGNALKGSFPVYFSTFSKLKKLDLSSNQLTGEISNSVSSLTDLVRLDISNNRLTGDPAAATAMLINLEELSLGNNQFVFNDVESFLQNFPNLRILDLAHTQLLAVPQKISGFPKLQSLNLSNNTLSQNFSALSTLLQLTELNLSGTQLIKIPVELSGLPLVTLDVSNNAFAPNYSMVLSNMSELEWLSLENNQLTALPRELAQLKKLVHLNLSGNKITGGFDGFSALKNLEQLYLNHNQIEGNFPAALLQLDKLQMLSLTGNQLTGEIPENIPQLTFLENNRFSQQDIRNFMLKEKVMAGFSYSPQRYDEAKAVPAVLGSSASLPQSLSGNSYEFSWFKNLDQKTPQTTENYHISKVEETDYTAYTCEAYYFEKLPKELLEISFFREPVTLVKQLGTEEIFRDLIVYPNPTSDYLTIRTTKLDIEKVYIFDLSGKLLFSSSTKHIDVRHLPSATYIISIKTYEGVKSFKFIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X251</accession>
    <name>C6X251_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02077"/>
    <dbReference type="EnsemblBacteria" id="ACU08514">
        <property type="protein sequence ID" value="ACU08514"/>
        <property type="gene ID" value="FIC_02077"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02077"/>
    <dbReference type="eggNOG" id="ENOG50323PV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116590_0_0_10"/>
    <dbReference type="OMA" id="WGLFNPP"/>
    <dbReference type="OrthoDB" id="1869492at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="159" mass="18925" checksum="B5264557AA00E178" modified="2009-09-22" version="1">MREKLRNMPLYLKSQEIFETVQTICDLIPPENEYLRDAKMHLLQNSMLIQVKISGAEAVLLWDQKIENAAIIRKCARELMVSYHSLKVFGFDEAEYYMIVRRQIEEFRILFREWVAGFNPKHFIVDEWGLFNPPGISQDYVQRDDELNFLDDEDLGFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X286</accession>
    <name>C6X286_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrous oxide reductase maturation transmembrane protein NosY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806833.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02112"/>
    <dbReference type="EnsemblBacteria" id="ACU08549">
        <property type="protein sequence ID" value="ACU08549"/>
        <property type="gene ID" value="FIC_02112"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02112"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071765_2_0_10"/>
    <dbReference type="OMA" id="RWSYVYF"/>
    <dbReference type="OrthoDB" id="1433825at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="255" mass="28213" checksum="A69414409AB922EF" modified="2009-09-22" version="1">MNKIARFILFDILKNKIIIFYTILLFIISWSVLGLEGNFTKATLSLLNVVLLVVPLVSIIFSTIYVYNSSQFIELLLSQPVPRAKVWFNIFLGLSTALILAFLIGCGIPIFLYSSIETGFSLIIIGILLSVIFTSFAMLSAIMSRDRAKGIGISIFIWIFFSIIYDGILLVLMFQFADYPIEGIMATLAGLNPVGLSRIFVLLQLNISAMLGYSGAVFQQVFGSGGGMGISMLILLLWTTVPFLMSLISFNKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X288</accession>
    <name>C6X288_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02114"/>
    <dbReference type="EnsemblBacteria" id="ACU08551">
        <property type="protein sequence ID" value="ACU08551"/>
        <property type="gene ID" value="FIC_02114"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02114"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682891_0_0_10"/>
    <dbReference type="OMA" id="HFQYNGW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="408" mass="46324" checksum="051598E7D64C396C" modified="2009-09-22" version="1">MQRTFWLKFSVFNFLLVALLGVLMRYKILYSLPFLDQKHLQEAHSHFAFYGWITHVLYVLLTNYLLKNKPQINYKTYNILIISNLIASFAMLGTFIYGGYFWASIAASTMALLTSFVFCYFFVRDVRSITDASKIWFVAGLFFAVISSAGVFNLAYMMGSKNVSQDMYLASEYYFLHFQYNGFFIFSCIGLLLYSIKEVGAVISEKQNKLMFWLMFFGCLIGFGLSVLWMKIPAFIFGLIVVASVSQTVGSLMLFNFVKKSWTNLVLAWSPTQRFVLIFVGFAFAAKIALQLGSNIPALNQFAFGFRNVVIAYLHLVLLMCIATFLVSQILATNYFTVGKRLLLGLKLVLLGIFLNEAILGIMGTFSIKYISVPFANQLLLLFSLLIFVGLALVFVNLKIKNAPLRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A6</accession>
    <name>C6X2A6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ordered locus">FIC_02133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806853.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02133"/>
    <dbReference type="EnsemblBacteria" id="ACU08569">
        <property type="protein sequence ID" value="ACU08569"/>
        <property type="gene ID" value="FIC_02133"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02133"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_10"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="16273" checksum="3A1C64DC36CC8EA3" modified="2009-09-22" version="1">MKVVIQRVSEARVKVDEQTVGQINSGLMLLIGIDEDDENTDADWLVHKILNLRIFGDNEGKLNLSVTDTGGEILCISQFTLIADYKKGNRPSFIGAAKPPKAIPLFEYFKNKIAGSGLKTESGIFGADMKVSLLNDGPVTIVMDSKTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K5</accession>
    <name>C6X2K5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="9" type="ordered locus">FIC_02234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806952.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02234"/>
    <dbReference type="EnsemblBacteria" id="ACU08668">
        <property type="protein sequence ID" value="ACU08668"/>
        <property type="gene ID" value="FIC_02234"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02234"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_3_2_10"/>
    <dbReference type="OMA" id="NRYQHKT"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="84" mass="9810" checksum="DD137E63214E7422" modified="2009-09-22" version="1">MANHKSALKRLRQNEKKRLRNRYYHKTARTALKVLRNEEDKTAATEQLPKVISLLDKLVKKNIIHKNKAANLKSKLTKHVNKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2K9</accession>
    <name>C6X2K9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806956.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02239"/>
    <dbReference type="EnsemblBacteria" id="ACU08672">
        <property type="protein sequence ID" value="ACU08672"/>
        <property type="gene ID" value="FIC_02239"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02239"/>
    <dbReference type="eggNOG" id="ENOG5030J41">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142320_0_0_10"/>
    <dbReference type="OMA" id="YAKVAYA"/>
    <dbReference type="OrthoDB" id="1687345at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="151" mass="17104" checksum="78A80238939D775B" modified="2009-09-22" version="1">MNFLRNTIAVLVGLAVAAVLISLGVRLNSAWITYDEFAPFEHWEELLAAMEHKPYFFVALLISSGIAATVGGVVTAIIVKYAKVAYAILIGFILLFIAMLDIIIFPYHPTFYKILIFLTFFPFSWIGGKITEVIYERKKKKLRRLNKKNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L6</accession>
    <name>C6X2L6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF3817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806963.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02246"/>
    <dbReference type="EnsemblBacteria" id="ACU08679">
        <property type="protein sequence ID" value="ACU08679"/>
        <property type="gene ID" value="FIC_02246"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02246"/>
    <dbReference type="eggNOG" id="ENOG5032QVX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120964_3_3_10"/>
    <dbReference type="OMA" id="GIAMIWK"/>
    <dbReference type="OrthoDB" id="1709780at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="112" mass="13595" checksum="81C716A0B811D272" modified="2009-09-22" version="1">MNIIEKFFAKYPEDKIIRWFKQICVAEALSWLFLFSAMIWIRYDRDGLLPTIYIIIIGNIHGLFFTLYLLFWLPARKIYRWDDEDSVFALIAAFFPFATIWIDKKLARFDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U6</accession>
    <name>C6X2U6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02326"/>
    <dbReference type="EnsemblBacteria" id="ACU08759">
        <property type="protein sequence ID" value="ACU08759"/>
        <property type="gene ID" value="FIC_02326"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02326"/>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080165_0_0_10"/>
    <dbReference type="OMA" id="FVEFHAY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="107"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="291" mass="33678" checksum="CD5DF9BAA99FEC89" modified="2009-09-22" version="1">MSMIMALFSDDINGNKMINKLKKLWEVYRHERYRENLQNVMNPKTGITPAERERVLAFPEFVPGEAHFFGQQLSFSHGPSFIHSIDEIFEEELYKFTSATQTPYIIDCGANIGLSVLYFKRLFPNSEIIAFEPDEKIFKILKKNTISLENVTLEKKAVWTEETTLEFFSEGALAGSVVTDFSNKNDIIKIEAVDLKKYLNRKVNFLKIDIEGAENTVFFDIADHLHQVQNLFLEYHGLINEPQNLGEILNILKDEGFQYYIRLAGETIKFPYCGEKPSTFNQQLNILCYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X7</accession>
    <name>C6X2X7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">FIC_02357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807074.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02357"/>
    <dbReference type="EnsemblBacteria" id="ACU08790">
        <property type="protein sequence ID" value="ACU08790"/>
        <property type="gene ID" value="FIC_02357"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02357"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005373_0_0_10"/>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="OrthoDB" id="1709134at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="195"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU08790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="531" mass="58876" checksum="B0BE8A606AC4CDCF" modified="2009-09-22" version="1">MTQKETLSSLIHGNFARELSISDGKMPPNAVDFEKLVIGTFLIDKKGLDYSIDLLTPEVFYDPRHQEIFRAILKLYEGNHPVDLMTVIQELKKNEKLGFAGGDHYIIDLTMGVSSSAHIEYHVRVILEKFILRSLINVSANVIDSSYKESTDVFELLDKAEQSFFEITNGTIKKGFDTANTLVKQAIETIKSLKDKEGISGIPSGFRDIDKETGGWQNSDLIIIAARPAMGKTAFLLSMARNIAVEHQVPLALFSLEMASVQLITRMIASETGISSEKLRKGQMSDEEWQRLFSNVSALENAPLFIDETPSLSVFDFRAKCRRLVMQHGVKIIMVDYLQLMTANSGKGGAGNREQEIAMISRSLKAIAKELNVPVIALSQLSRSVETRPGKRPMLSDLRESGAIEQDADIVSFIFRPEYYKIATWDNDEDGGESSTENQAELIIAKHRNGATADVRMSFFKNIAKFADLDLFGNQHGNGYQPSNFGAMDAPGGFEKIKATIDPGAAFDLPGNQNVSGSSMNDLDDDDEFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X304</accession>
    <name>C6X304_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807101.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02384"/>
    <dbReference type="EnsemblBacteria" id="ACU08817">
        <property type="protein sequence ID" value="ACU08817"/>
        <property type="gene ID" value="FIC_02384"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02384"/>
    <dbReference type="eggNOG" id="ENOG5031M58">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132526_0_0_10"/>
    <dbReference type="OMA" id="KRQNQFV"/>
    <dbReference type="OrthoDB" id="1921482at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025635">
        <property type="entry name" value="DUF4293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14126">
        <property type="entry name" value="DUF4293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="129" mass="14550" checksum="DA961DC77628CFD1" modified="2009-09-22" version="1">MLQRIQTVWIFLAILGAIFLFITGQDFSVFGPVPFISVVCSVLVFLGFSAILSYKNRKRQILLNHISIFINALLLGLLAYWLLMLSGGINFPEKGIEPAFPILSIICLLLANLSIRRDDRLVKSVDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X315</accession>
    <name>C6X315_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine aminopeptidase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807112.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02395"/>
    <dbReference type="EnsemblBacteria" id="ACU08828">
        <property type="protein sequence ID" value="ACU08828"/>
        <property type="gene ID" value="FIC_02395"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02395"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047420_0_0_10"/>
    <dbReference type="OMA" id="NNDMIGN"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972264" evidence="3">
        <location>
            <begin position="19"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="111"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="447" mass="49437" checksum="5BE23C2B5BA4DC0E" modified="2009-09-22" version="1">MKKIISLMLLLTAFNINAQNRVTDPEIEALVKKVNKDSLRAHVEKMVSFGTRHTMSSTTDANRGIGAARNWVLSKFKDYAQNSGGRMEVYLQNKDLQPDGRRVNNTTNLGNAVALLKGTDPNDNRIIIVSGHLDSRVSDVMNAESDAPGANDDASGVAAVIEAARILSGAKLSASVLFVAVSGEEQGLLGAKMLADQAKAEHWNILVVLNNDMIGNNSFDAQNKNEKPKLRVFSEGLPAFETEKSAVNLRNLGLENDGSARQLARYIKETGENYVKNIDIKLIYRNDRFLRGGDHTPFVVNGFTAVRLTDYYENYDHQHQDIRTENGKQYGDLIEFMDVDYLKTNTQVNVAVLANLAKSPASPLNVRMDVKELSYTTKITWDKPSTGTVKGYHILVRETASPVWQQKIFTKETTISIPYSKDNFLFGVQSISEAGNESLPIIPGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X342</accession>
    <name>C6X342_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable glutathione S-transferase-related transmembrane protein</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02422"/>
    <dbReference type="EnsemblBacteria" id="ACU08855">
        <property type="protein sequence ID" value="ACU08855"/>
        <property type="gene ID" value="FIC_02422"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02422"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_6_0_10"/>
    <dbReference type="OMA" id="ERWWGPP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="173" mass="20184" checksum="A0F122D92115C7A8" modified="2009-09-22" version="1">MIKNTVMATEIVFNKDYDSAGIFVMKVLDADIPTVWAHFSQAQLLDLWWAPKPWKCETLHLDFREGGSWTYAMIGPENDRQFAGATYHEINLNRSFDWTDYFTDENGNKDTRMPTVKWLFGFTGVEEGTKLTINIHFNSEEEMKQLVEMGFEQGFKQGLNQLEELLRQKDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X389</accession>
    <name>C6X389_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ordered locus">FIC_02469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807186.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02469"/>
    <dbReference type="EnsemblBacteria" id="ACU08902">
        <property type="protein sequence ID" value="ACU08902"/>
        <property type="gene ID" value="FIC_02469"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02469"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_0_10"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="413" mass="46445" checksum="44AE1747470B81D4" modified="2009-09-22" version="1">MLYYLYEYLTSHGIHVPGLGMFRFISFRAGMAVLLSLVIALIFGKKIINYLRKKQMGEQVRDLGLEGQKQKEGTPTMGGLIIILATLIPVLLFTRILNIYIVLLIISVVWMGAIGFIDDYLKKIKQNKDGLSGKFKVIGQVGLGLIVGVIMYFHPDVTVKRKYADAKEINRNTVERNFMPTEKSTVSTVPFVKNNEFDYSGILFWMTPEEAHEWAWIVFIPMVIFIVTAVSNGANISDGIDGLAAGTSVVILLTLAFFAYISGNIIFADYLNIMFLPNMGETTIFALALVGAVIGFFWYNTYPAQVFMGDTGSLMLGGVIAVLAIILRKELMIPVLCGIFLIENISVMLQVAVFKYRKKKFGLEYAQNNRLFKMSPLHHHYQKEGYHESKIVNRMIIMGVLFAIICLITLKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X391</accession>
    <name>C6X391_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein ftsI (Peptidoglycan synthetase)</fullName>
            <ecNumber evidence="3">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.129" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807188.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02471"/>
    <dbReference type="EnsemblBacteria" id="ACU08904">
        <property type="protein sequence ID" value="ACU08904"/>
        <property type="gene ID" value="FIC_02471"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02471"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_4_10"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="604"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="663" mass="74294" checksum="D4BFF1C492F20EFF" modified="2009-09-22" version="1">MAVKNEFEAKRSKTLRWGYLFVGAAFILFVVFLARILVLQNTNVQAIKQDYISKNYREATLKAARGNLYAADGSILATTVMRYDVFLDFKTIKDTVYSNNIAALTDSLSNMFGKPRSYFRDRLDQQRKAQNQYYSLVKGLDFDDYDRIRKFPIFKKGKNKGGFIIDRNFKRELATTQIGAGTIGMDNGVAKSGLEGAFSKYMTGSDGTRLEQRVNSSQWKPIDYWRVKEPVDGQDVYTTIDLRIQDIAHSALEKQLINFDADHGSVLVMEVATGKVKAMVNLKRTEPGMYVDSYNYALKDATEPGSTFKAVSLLAAMDDGFIDENTTVNVGNGVWTYAKQRISDGHGGGVYEIADVLAKSSNVGSAKLITQYYADKPDVFLDHLKRWKMFDKMEIELPGITKPFIVTPENKRWNAATLASLSYGYSSRFNLLQLTTFYNGIANKGKMLKPLFIDKIMKDGQELYTAKPEVMVNKMASAKAITMMTNALTKAVEKGTAKSIFTPNLKMAGKTGTARFEYWKPGPAKYQASFAGFYPADNPKYTCIVMVNQPDPSKSYYGSTVAAPVFKEIAGKTFLKTPQNVEPEMLVDKKVDLSRMVGPNVKVAVRGKQMPKVVGLIGKNVIPQLENQGYRVDYKGVGRIREQFPLEGTTINKDQRIYLSLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C2</accession>
    <name>C6X3C2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02502"/>
    <dbReference type="EnsemblBacteria" id="ACU08935">
        <property type="protein sequence ID" value="ACU08935"/>
        <property type="gene ID" value="FIC_02502"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02502"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109792_0_1_10"/>
    <dbReference type="OMA" id="NSIQGWR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021474">
        <property type="entry name" value="DUF3127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11325">
        <property type="entry name" value="DUF3127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="156" mass="17874" checksum="A2BFE58B8D230527" modified="2009-09-22" version="1">MNFLFVQKNQCPLSFSSYNLLLLHLNIKTMELQGTIKKITDVQTFPSGFQKREMIILTEEQYPQPISIEFLQDKTDLLNNYNEGDKVKVSINIRGREWTSPQNEVKYFNSIVGWRVEKSEGGSAHEPVEARPSQPNTTSAAGNTNVFEEDEDDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C3</accession>
    <name>C6X3C3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807220.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02506"/>
    <dbReference type="EnsemblBacteria" id="ACU08936">
        <property type="protein sequence ID" value="ACU08936"/>
        <property type="gene ID" value="FIC_02506"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02506"/>
    <dbReference type="eggNOG" id="ENOG50333R9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152583_1_0_10"/>
    <dbReference type="OMA" id="TREMDTI"/>
    <dbReference type="OrthoDB" id="1997313at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="113" mass="12957" checksum="6A995D5D38E671D5" modified="2009-09-22" version="1">MQPRPMLTLSQVMAKLAAKDVTQEFTMNDACEMKLRETGEIYQPEDLKILRTYRFEADSSPEDNAVLYVAQATDGNIGMIIDSYGAQSNYEGPEFDNFIREIPIEEDENYNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D2</accession>
    <name>C6X3D2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807229.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02515"/>
    <dbReference type="EnsemblBacteria" id="ACU08945">
        <property type="protein sequence ID" value="ACU08945"/>
        <property type="gene ID" value="FIC_02515"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02515"/>
    <dbReference type="eggNOG" id="ENOG502Z8VK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108506_0_0_10"/>
    <dbReference type="OMA" id="GWGQLIA"/>
    <dbReference type="OrthoDB" id="1728591at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="204" mass="23556" checksum="5B441B94470FAC02" modified="2009-09-22" version="1">MRYEKLRENNFNHWFIIHLRYVLGVAFIPSGFTKLVGNRFTSISANHPIGYFFEALYQSGFYYNFIGFAQLLAGFLLMTQRFSTLGNLIYFGLTVNICIITISLSFKGTWIITSLMLFASTVLLIWDYQKLKPLFSYGSLQSVRPYIEPSVYWQIAGLVYFFSIISLSVFNFNTGSGLFVAGLIVVTFIVSNIMSYRKYRQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E4</accession>
    <name>C6X3E4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807241.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02527"/>
    <dbReference type="EnsemblBacteria" id="ACU08957">
        <property type="protein sequence ID" value="ACU08957"/>
        <property type="gene ID" value="FIC_02527"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02527"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_18_1_10"/>
    <dbReference type="OMA" id="PYCEVAW"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="456" mass="53938" checksum="7C1D6CA9673CDB0A" modified="2009-09-22" version="1">MEEFFENELVKKFEEMVENNDELYFETEEYEDIIIYYLEMGDISFAETATNFALKLHPNSLELKIKKFEVFLELENYTQAKELMLELKESSMESTDFLVCCAKYYSNLGNPRRAIEYCEKALELEEEENFLHNFIADECVNLEDPFNALKHYKLALTFDQQDEYSLENIMVCYNQLNRSDEAIEFLNGYLNKFAFSETAWYEYGQFYFNRKNYEEAIRGFDYLLAINPQSVGVYANKAACLEAMGEWLKAIAVYEEMLELEYTKSFTYYKIGLCYKENKQQTLALQAFQKSLRDDPQFYLSMMEQSYIYEEMGGMKEALHFAKEAVSMNDTNLDYQKRLAYLYIDSGRFEESLVCLRKLADLEPSRFYNWYAYSEVLMLIGEYEEAIQVLNKATNLHNRAEIYYQLSNCCFHVNNQKGGRAALATALELDPNLLEDMKQKYPFLREEAERVKTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G4</accession>
    <name>C6X3G4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ordered locus">FIC_02547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807261.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02547"/>
    <dbReference type="EnsemblBacteria" id="ACU08977">
        <property type="protein sequence ID" value="ACU08977"/>
        <property type="gene ID" value="FIC_02547"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02547"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_2_1_10"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="211" mass="22755" checksum="D6F42542A2D5C4A0" modified="2009-09-22" version="1">MKSITIQGTKRENVGKKSTKALRDAELVPCVVYGGAETLNFSAEERSFKGLVYTPEAHTVSIEVDGNTIPAVLQDIQFHPLTDKILHADFYQLDENKPVVMEVPVRLTGRSKGVVAGGAMRQSFRKLKLKALPANLPDEIVVDVTPLKIGSKLYVGDIPTENFTFMHPDNAVVVAVKMSRTASKGGAAADDDEEETTAEGEAPAAEETSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K4</accession>
    <name>C6X3K4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-aspartyl dipeptidase Peptidase E</fullName>
            <ecNumber evidence="4">3.4.13.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.21" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782139.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00534"/>
    <dbReference type="MEROPS" id="S51.002"/>
    <dbReference type="EnsemblBacteria" id="ACU06992">
        <property type="protein sequence ID" value="ACU06992"/>
        <property type="gene ID" value="FIC_00534"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00534"/>
    <dbReference type="eggNOG" id="COG3340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071689_0_0_10"/>
    <dbReference type="OMA" id="RDHDKYT"/>
    <dbReference type="OrthoDB" id="1485646at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="230" mass="25587" checksum="A437DBEFF49CA15F" modified="2009-09-22" version="1">MNIVLASTSTLFGGNYLEYLKDQITVLFEGCDEIIFVPFARPGGISHEDYTQKAGEFFSKIGIKLRGLHEFEDKSAAINAAQGFFTGGGNTFLLVKMLHDLDLMRTLKQNVESGKPYLGCSAGSNIGGLNMKTTNDMPIVYPPSFECMGLVPFNINPHYLDPNPELKHNGETRETRIKEFLTQNDTRVVGLREGNWIRRTGDTITVEGSEMTRIFVKDAEPYELPPGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K8</accession>
    <name>C6X3K8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782143.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00538"/>
    <dbReference type="EnsemblBacteria" id="ACU06996">
        <property type="protein sequence ID" value="ACU06996"/>
        <property type="gene ID" value="FIC_00538"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00538"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_4_1_10"/>
    <dbReference type="OMA" id="MSEAGCP"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="232" mass="26204" checksum="934CFD98BFC6C388" modified="2009-09-22" version="1">MLFLIPAYLSENSSQSYFAPAIKEYILKTDFFFVENEKTGRKVIKFFAPEKKQADLKLFLLDKYSQTSDVKEALALMKNGQDFGLLSEAGLPCIADPGNLVVKWAHEHSVKVVPVNGPSSIILALISSGFNGQEFTFHGYLPIDKSEKKARIHALENEVQKTGYSQIFMETPYRNNPLFEDLCRFLSPNTKLCIAANINDPADEFIRSLTVREWANNKPELHKIPAIFILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M3</accession>
    <name>C6X3M3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">GAR transformylase</fullName>
            <shortName evidence="4">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">purN</name>
        <name evidence="7" type="ordered locus">FIC_00553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GART family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00553"/>
    <dbReference type="EnsemblBacteria" id="ACU07011">
        <property type="protein sequence ID" value="ACU07011"/>
        <property type="gene ID" value="FIC_00553"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00553"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645218_0_0_10"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042281">
        <property type="entry name" value="GpdQ_beta-strand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042283">
        <property type="entry name" value="GpdQ_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos_2" evidence="6">
        <location>
            <begin position="195"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="4">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="4">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="425" mass="47312" checksum="B19B97EAB08D981D" modified="2009-09-22" version="1">MSVAKKKITVLVSGSGTNLQRIIDCVQSDEIRNTEISAVIADRECLALERAAKHGIKNVRLQRGPDFSSQLNKVIPADTDLIVLAGFLSILDKHFCENFSGKIINIHPALLPKFGGKGMWGKHVHTAVLSAGEKESGASVHYVTAGIDEGGVILQQSFPVSEKETPDTLAEKVHAIEHEILPKAIDQLLNKSDQIAFITDLHLHEKNVSKKGVDAVANWKTVLQDVKARGISRIILGGDLGEKEALKIIFDDIKDFDFRLILGNHDKISDFRTFFAETVGKQELYYSAQISGNDCIFLDTSSYKLSQEQRSYLKNWLGSTENPVVFIHHPVLDDGSWMDKEHPLKNKTQVEEILRQSGKNVTLISGHYHHFYKVTSDKIRQVISPAVSYQILNSKSYQADTKSFGYLILGFSEQEVSIEAVNFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q9</accession>
    <name>C6X3Q9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782194.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00592"/>
    <dbReference type="EnsemblBacteria" id="ACU07047">
        <property type="protein sequence ID" value="ACU07047"/>
        <property type="gene ID" value="FIC_00592"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00592"/>
    <dbReference type="eggNOG" id="COG2352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_10"/>
    <dbReference type="OMA" id="PWVFGWT"/>
    <dbReference type="OrthoDB" id="398146at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="846" mass="97389" checksum="F3DABB9969879C83" modified="2009-09-22" version="1">MQNQEKTEKFRQIVENKFQIYNSLFMSLPYDKMTNIGMLLPFLYEESKAGYENGKNPVEIVEEFFSKHTGLESEGQKTELLFKIIQYIERQVVLFDSIEDAAFAELHPAGETGTLLQLYDRSLQQHQLEATRAKMKDFAVRVVFTAHPTQFYPSSVQRILHDLRSAIMKDSVTEIDMLLQQLGKTPFLNREKPTPLDEAMSIIFYLRYVYYDSLGELYAKIKNSFGDGDFVPPHDIFQLGFWPGGDRDGNPFVTAETTLQVAKELNSSVLKSYYEHLKKLRRRLSFRGVSEVLDMLSDALYDAIFKDQHITSDEILNRIHEAQQILNGKHNGLFGDLLDDFEDRVKIFGTHFATLDIRQDSRVHQNVIDEIVMKKSDLQSENIMNEDKLKWLLETDVILNPEDFEGITQDTLRNICNIKDIQKINGARGMSRYIISNSDGIKDVLNVFGLFRLCGYKEDDINIDIVPLFETMEGLDAGEGVMRELYELPVYRKHLERRGNAQTIMLGFSDGTKDGGYLKANWEIYETKEQLTKVSDENNIKVIFFDGRGGPPARGGGKTHDFYASQGKTIANNKIEITIQGQTITSVFGNKDQAKYNFEQLLTAGIENDVFKNSKKDLTENERNLIRELAEISFKKYSDLKAHPMFVPYLQEMSTLQYYGKTNIGSRPSKRAGNDELKFEDLRAIPFVGSWSQLKQNVPGFFGFGFALHQLKMQGRFDEIRALYKGSDFFKTLVLNSMMSMNKSYFPLTYYMKNNLRFGGFWSILFEEYELSKALMLELTGFKMLMEEEPLSRKSVKIREKIVLPLLSIQQYALMKIQKGEGNREAYEKLVMRSLFGNINASRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R7</accession>
    <name>C6X3R7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ordered locus">FIC_00600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782202.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00600"/>
    <dbReference type="EnsemblBacteria" id="ACU07055">
        <property type="protein sequence ID" value="ACU07055"/>
        <property type="gene ID" value="FIC_00600"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00600"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_0_10"/>
    <dbReference type="OMA" id="RFGYHEF"/>
    <dbReference type="OrthoDB" id="708179at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="344" mass="39309" checksum="FF2F47E912748106" modified="2009-09-22" version="1">MKKEIKILAGVALLIVLIAGVFGYQFYKKYYGNNVAKEAFILIPHSANFNSILDSISPFLKNKEQFIEVAESKSLPKFFHAGRYQIKSGTNNTDLVNMIKAGNQTANTFRIGDFGDVYQMIGRVTKKTELDSLRFAKDLDKIAASKGYNNAEDLKKYFFIDTYDFFWTVTPDEFFKRFEGIYTDFWTADRLAKEKASGLTRDQIYALASIVYKESGGKPDEQKTIAGLYLNRYRKGMKLQSDPTVIYAINKESNFTTPIKRVFYKHLRHPSPYNTYANAGIPPGPICITDKNSVDAVLNAEKNSYIFMAADPERFGFHRFTASDTEHAKNAKDYQEWLNSKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3U2</accession>
    <name>C6X3U2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07080">
        <property type="protein sequence ID" value="ACU07080"/>
        <property type="gene ID" value="FIC_00625"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00625"/>
    <dbReference type="HOGENOM" id="CLU_1265381_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="218" mass="25324" checksum="5503DEC35684B832" modified="2009-09-22" version="1">MKICASVSRPNAKPRNVTGNTIKSTNMKFILYIFTIFYVFAGCSEKKEMKLSNEKQSGIVSDEFIYSFVNDALSQNDIYKYCENIIDIKTFIATNGDSTLISKIDTIFSQEDKTFIGEQYLRGNKFVWKNKLRNKKIIKVDTTINNEDSSKEYWKNLLQEKKCFGYLELPLFNKAKNMAIVTISYNCGMLCAEGGTYIYKLDKKNQWKLYLTLEHWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3U3</accession>
    <name>C6X3U3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07081">
        <property type="protein sequence ID" value="ACU07081"/>
        <property type="gene ID" value="FIC_00626"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00626"/>
    <dbReference type="HOGENOM" id="CLU_118509_0_0_10"/>
    <dbReference type="OMA" id="RETHIPY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="199" mass="23230" checksum="4E86F3091B170B49" modified="2009-09-22" version="1">MEFCGYKSVESLIVLQSILSLSFLNKSNIPIFLFCSNCFILFMLFTHCEKSNEEYLDDFKNYDVTLSNSDFDINLKNGKIESDYFKMMDSIKFSKKEKIEFAKLFFDNNLKKLNGDLVIYNNDGISIHPDIGTSIRIKYFAIDKSTVSISGFADSLKVRETHIPYLRFESKAYKILENNKEFQKIKKKIASKEDDRVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V7</accession>
    <name>C6X3V7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical Membrane Spanning Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00640"/>
    <dbReference type="EnsemblBacteria" id="ACU07095">
        <property type="protein sequence ID" value="ACU07095"/>
        <property type="gene ID" value="FIC_00640"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00640"/>
    <dbReference type="eggNOG" id="ENOG502ZBSZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003812_0_0_10"/>
    <dbReference type="OMA" id="ANDCDGL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="277" mass="32075" checksum="1859E29B28D1CC45" modified="2009-09-22" version="1">MPRQITAVWQKSGRKFSVWKFCLDLKGGFIKKILAARFCAKPPTVVRYFNPSYRKMNEILEINGTIFLKINSDSIEENLRFAEKNKIFNFLISARIGNYKLNNIDFVKDFSQLEMLYISVYENINYQAIKHLKNLNTLSIDVLSNDTQEIDFSNLLNLQKLVFTWRPKAKNIHSLKLLKDLTITKFSKINLALLSSLENLEDLGIFQSKIENLEGAEKLLNLKKLTIVDCKKLENIDSLGSLENLHQIKIHNCGNIKKPENITFINKIELLESSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W9</accession>
    <name>C6X3W9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription elongation factor GreB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00652"/>
    <dbReference type="EnsemblBacteria" id="ACU07107">
        <property type="protein sequence ID" value="ACU07107"/>
        <property type="gene ID" value="FIC_00652"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00652"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_3_1_10"/>
    <dbReference type="OMA" id="NWGSPLG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GreA_GreB" evidence="1">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="183" mass="20639" checksum="FB257520A47F4447" modified="2009-09-22" version="1">MMVRTENCSFKLLKRTIMSRGFVKEDDQEEIPLVPPRADLPIWAENWVTPAGMEALQQERADLISEQEKLDPSHEREYRIAFNHLNARLQLLNGRMASAKIIDTARLSQGEVHFGATVTFKNLNNNLRQTFQLVGVDEANISKGKLAFTTPLAKALINSKVGEKVTLQLGDKTNIFEILSIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X445</accession>
    <name>C6X445_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782329.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00728"/>
    <dbReference type="EnsemblBacteria" id="ACU07183">
        <property type="protein sequence ID" value="ACU07183"/>
        <property type="gene ID" value="FIC_00728"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00728"/>
    <dbReference type="eggNOG" id="ENOG502Z8EB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796187_0_0_10"/>
    <dbReference type="OMA" id="LLEQWYL"/>
    <dbReference type="OrthoDB" id="1074060at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="351" mass="41329" checksum="2669BF9B15336EBC" modified="2009-09-22" version="1">MKKIAYIELDTHAEIAVNFMDLMHDSSEFSVDYFFSSKILKQTNNTGKNIFEVTHATLFNQLQQTDYDLVIIGTVHRYFDIFFKVAEKFNSAVVVHNINFTKLSGFQLFKNVFKADFKYRLKLLLKEGLFSAPNVFAGAKNLMVLDESLIEKNKELELKFMPVFYFHKYEKPRKSIITIVIPGAVSQQRRDYLHVLKQIESFKRNTHFQFVFLGKARGKELSWIKEFEQSKLKNISLKYFTEKVPQTIFDRWMQAADILWCPIQSETEFFSNKEFYGITKISGNVGDAIKYGKLAIFPENYPNSHPFIIPEHTNIEEEIYTYNKWMDYDLEQNFAKQKVLKSLEKTLSELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X460</accession>
    <name>C6X460_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00743"/>
    <dbReference type="EnsemblBacteria" id="ACU07198">
        <property type="protein sequence ID" value="ACU07198"/>
        <property type="gene ID" value="FIC_00743"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00743"/>
    <dbReference type="HOGENOM" id="CLU_2649164_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="76" mass="9028" checksum="DB193DCCA6312D61" modified="2009-09-22" version="1">MILKIGQKPKHAPASYSICEYFGEAVVAQDIINANANRVNRYFIFIIWLMVSTIIPKKKDLRYFKSIFNFYWFLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A8</accession>
    <name>C6X4A8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782392.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00793"/>
    <dbReference type="EnsemblBacteria" id="ACU07246">
        <property type="protein sequence ID" value="ACU07246"/>
        <property type="gene ID" value="FIC_00793"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00793"/>
    <dbReference type="eggNOG" id="COG5061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072282_2_0_10"/>
    <dbReference type="OMA" id="TEYILIG"/>
    <dbReference type="OrthoDB" id="1452951at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="233" mass="26918" checksum="B4FE8483F8F6C3F7" modified="2009-09-22" version="1">MIFIPLILAHLFGDFLLQPNYWVADKERKKTRSIYLYIHVLLHAALSYIVLWNIKLWWIAMIIGVTHFIIDSAKLHFQNHKTKRIWFFTDQLLHILVIAALSVFYFPYLQWSDIFTPENLKIITAIVFLTVPSSIFIKTLISIWTPITAEQSSFQTESLVNAGKYIGILERLLVFVFILVNHWEGVGFMIAAKSVFRFSDLADAKQRKLTEYVLIGTLLSFGIAVVTAILVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B2</accession>
    <name>C6X4B2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-dehydroquinate synthase</fullName>
            <ecNumber evidence="10">4.2.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782396.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00797"/>
    <dbReference type="EnsemblBacteria" id="ACU07250">
        <property type="protein sequence ID" value="ACU07250"/>
        <property type="gene ID" value="FIC_00797"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00797"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_1_10"/>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="53"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="346" mass="38707" checksum="572BF0A004BE86DF" modified="2009-09-22" version="1">MITFLEKDFAPFSQFLDHLRPSKLFILVDENTHELCLPTLLGNLETEIPLEIIEIEAGEDLKTIETTTQLWEILAEFEADRKAVLLNLGGGVITDLGGFVASTYKRGIRFINMPTTLLGMCDASIGGKTGIDHQFLKNIVGTFAEAEQIFVFPDFLSTLPFTELRSGFAEMLKHGLIADEKHWKDLSSITDLTPQNIAPYLETSMRIKQNVVGQDFREQHIRKTLNFGHTIGHAAESLFLQMNEPVAHGEAVALGMICETRLSFLQNLITEETADHIISNIRKFFPKLDISAFSEQNLISLMQNDKKNTGGYISFSLIDGVGSGVFDQKISDEIVISALQYYQNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C3</accession>
    <name>C6X4C3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaerobic C4-dicarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782407.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00808"/>
    <dbReference type="EnsemblBacteria" id="ACU07261">
        <property type="protein sequence ID" value="ACU07261"/>
        <property type="gene ID" value="FIC_00808"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00808"/>
    <dbReference type="eggNOG" id="COG2704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036056_1_1_10"/>
    <dbReference type="OMA" id="PKQINYL"/>
    <dbReference type="OrthoDB" id="591678at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015556">
        <property type="term" value="F:C4-dicarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004668">
        <property type="entry name" value="Anaer_Dcu_memb_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36106">
        <property type="entry name" value="PTHR36106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03605">
        <property type="entry name" value="DcuA_DcuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004539">
        <property type="entry name" value="C4-dicrbxl_trns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00770">
        <property type="entry name" value="Dcu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="443" mass="47020" checksum="A5ED6B7BD50B3657" modified="2009-09-22" version="1">MDYAIYLQLLVVLAAIFIGAKVGGIGLGIFGMIGMAILVFVFGLAPGEAPIEVMLMIVAVITAASALQAAGGLDYLVQVAEKILRKNPAAITFLGPLVCYVFTFLAGTGHIAYSLLPIISEIATDSKVRPERPMSISVIASQQAITASPISAATAALLSTSLLGGQGIEMIDILMVCVPATIIGVLVGALAVNFIGVDLEKDPIYLKRLQEGLIQTKEHKASVAENSSTRPLIAVILFLVGVFSVVIFGSFSDLRPSFLIDGEMLKITMPQIIEIVMMSAAGLILVFAKADVTKAVNGSIFIAGMQAVIAIFGIAWLGDTFFNGNLAFFKDNIQSIVTTYPFLFAFALFVMSILLFSQAATVRTLYPLGLALGIPPLALLAMFPAVNGYFFLPNYPTVVAAINFDRTGTTRIGKYVINHSFQIPGMVSTIVAIAVGYLIISFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4G8</accession>
    <name>C6X4G8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="7" type="ordered locus">FIC_00853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00853"/>
    <dbReference type="EnsemblBacteria" id="ACU07306">
        <property type="protein sequence ID" value="ACU07306"/>
        <property type="gene ID" value="FIC_00853"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00853"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_0_10"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="5">
        <location>
            <begin position="80"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="168" mass="19601" checksum="96B363EC5046CEB4" modified="2009-09-22" version="1">MHQINEKIRAKEVRLVGDNVEPGVYPLSKALEIAKDQELDLVVISDKAEPYISRILDYKKFLYEQKKKTKELKAKQVKVVVKEIRFGPQTDDHDYEFKKKHAEKFLEEGSKLKTYVFFKGRSIIFKDQGEILLLKLAQELEHVGKVDQLPKLEGKRMIMMMSPKKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I3</accession>
    <name>C6X4I3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloprotease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00868"/>
    <dbReference type="EnsemblBacteria" id="ACU07321">
        <property type="protein sequence ID" value="ACU07321"/>
        <property type="gene ID" value="FIC_00868"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00868"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007507_0_0_10"/>
    <dbReference type="OMA" id="NNMMHDI"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973688" evidence="1">
        <location>
            <begin position="39"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="465"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="808"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="881" mass="95431" checksum="8FDED3B14E47795B" modified="2009-09-22" version="1">MIFFINSVPINQLYMKNRNLSLKIAAVCFMFSFGSASAQDFQSIIQQHISAKNTFMKPDLNNFEIIAQDFSKSMNADVIKVQQAYNGIPVYNAVATAMIKDQKISYFNDSFAKNYVNTSNTSSAKASKAVFEDVAQALGLKNSDIYRLISVKDADLDVPFAKTRLVYLLTPQNDLRLCHEFIFEEKGTSNYWDILADATTGEILNKENLTVSCTFKHDAYHHGYSAHTPEGFTNDFTQSGKSAEATTLAPLDASYRVFPLPVESPSHGGRALVSNPWFTDASPEGWHTIPGGTYAGVFTTTRGNNVMAYDDKNSMNTAGAYAEGGAGRVFDFPFVLNDTPGNLNAATTNLFYINNKIHDIFYRLGFTETARNFQAWNFGKGGNQNDYVQAESQDGGGTNNANFSTPGDGSRPRMQMYLWEPSVIERVFYNSPPEAVGREVQNYISTTFGPALDATGVTADVKLSPILDACTALPAESLTGRIGLIERGTCDFVVKVKNAQNAGAVAAIIYSLPTSTPTAGMAGVDATITIPSVLIENSEGVYMKGLLQASTPVNVTLKYDPLMQKTRDGSFDNGIVIHEYGHGISTRLVGSLSSSVNKEQMGEGWSDFFALMLTNRPGDDASVPRGIGTYATTEPISGGGIRPAQYSPDFGINNYAYGDTNGMEYTNTAGVLVPDVHSIGFVWASMLWDLHWKFVEKYGYSSDVMSNSTNGSTKVLQLVVDALKLTPANPGFIQGRDAILAADEATSGKADKCMIWSVFARRGLGVNASAGLANNINDQVQDFTEPPLDPACTGLATSETNANNALSIYPNPAKNEFFLKSPKSIVGKVHVEIFDASGKLVSSQKISSSDAVNTQAIPNGFYLVKVTGLGVNYSSKLIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q5</accession>
    <name>C6X4Q5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, short-chain specific</fullName>
            <ecNumber evidence="9">1.3.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782539.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00942"/>
    <dbReference type="EnsemblBacteria" id="ACU07393">
        <property type="protein sequence ID" value="ACU07393"/>
        <property type="gene ID" value="FIC_00942"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00942"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_3_10"/>
    <dbReference type="OMA" id="TRQVFFN"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004085">
        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="147"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="257"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="595" mass="65734" checksum="AFB8BD0E063368E6" modified="2009-09-22" version="1">MSDTIQNLKGGEFIIRDIPANEIFSLEELSDEQKMLRDSIREFVDKEVVPHRERFEKKDYALTEEVMRKMGEMGILGVAVPEQYGGLGMGFITTMLACDMASGANGSVATAYGAHTGIGTLPILLYGSEELKNKYLPDLAAGTKFGAYCLTEPDAGSDANSGKTKARLSEDGKHYVINGQKMWISNAGFADTFTFFAKIEDDKNITGFVINRSELEDPAQMTMGEEEHKLGIRSSSTRQVYFNDMKVPVENVLGERNNGFKIALNALNVGRIKLAAANLDGQRRILALATQYANERKQFGVAIATFGAVRKKIAEMATGIFVSEAGSYRAARDIQDKIDELVAGGMNHQEAELKGVEEYAVECSILKVFVSDLTQHTADEGIQIYGGMGFSEDAPMEAAWRDSRISRIYEGTNEINRLLAVGMLIKKTMKGEIDLLKPAMAVGKELMGIPSFDVPDYSELLSEEKALLTNLKKVFLMVSGAALQKYMMDIEKQQHLLLNASEILNQIYMAESAILRAEKHFSADSVEVAMAQLNLYKAVEKIIAAAKEGIVSFAEGDEQRMMLSGLRRFTKYTNQPNVIALTEKIAAHYVERGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R9</accession>
    <name>C6X4R9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782553.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00956"/>
    <dbReference type="EnsemblBacteria" id="ACU07407">
        <property type="protein sequence ID" value="ACU07407"/>
        <property type="gene ID" value="FIC_00956"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00956"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038123_0_0_10"/>
    <dbReference type="OMA" id="IYIDPSR"/>
    <dbReference type="OrthoDB" id="1249244at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="333"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="388" mass="43586" checksum="BA2AD04B307E2C88" modified="2009-09-22" version="1">MQQGFNPQILSEDVQKYINANLQTDLHSLLLKKSPFGGVTMSEIVQQIKGRNVAARKFPFLLKDGIVFPPNLNLEQASSQATAEFKSKDLRGNTFLDLTAGFGIDAYFLSQNFDEVTLVEQNAVLSETVKHNWQVLGRNANFCIENLESFLARNSGPFDLVYLDPARRDLDKNKKFLLGDLSPNLLEIHAKLLQISRSIIIKLSPLIDISYLISVLPRITKIQIIAVRNDVKELLVFISLDAGSNDVQISCVNLESDEAVFNFNFAEEKSAVADYSEPLAYIFIPNNSVLKSGAFSLTSEKFGLRKFHPNSHFYTSNTSVADFPGRMLKAERIDSKQIKKSEKFNIISKNYPLSPDEIKKKYKISDGGENYLIFTQTINGKVILKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T3</accession>
    <name>C6X4T3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent outer membrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00970"/>
    <dbReference type="EnsemblBacteria" id="ACU07421">
        <property type="protein sequence ID" value="ACU07421"/>
        <property type="gene ID" value="FIC_00970"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00970"/>
    <dbReference type="eggNOG" id="COG4772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_13_2_10"/>
    <dbReference type="OMA" id="DWDYAPR"/>
    <dbReference type="OrthoDB" id="514956at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973692" evidence="1">
        <location>
            <begin position="20"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="47"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="733" mass="82973" checksum="40107149A9125E6D" modified="2009-09-22" version="1">MKIKYIFIVLLSTSGWANAQETEKNIEAVDIHARNKVSKEREEFKRHAQSTEIISEYEINRNNPAFIEQSLNTMAGVQVEKRTQVGGQRIILRGYGNDQKFNSWGVKMYLNNIPITGADGVTVLDDVNFGLIDHIEVIKGPAATLYGGGSGGAVRFYVRPENKKGSSVAEQFTTGSFGLFQSSTTLTNVGDNHSITANYSHFGSDGYRPHGKSIKNFYTVNGEFKLNTKQKITLFASHGNSLEQVSGQISYDDYYNGIDNGNNAYIRRNAKTKFITSRVGIGHIWDLSPNLKNNTTLFYSGTTSDRIAAGASETYSAPNYGLRSVFNYTKDWEDFKSQSEFGLEIQQSRSLISNYRFKSVKSTEAPVLRPAYDGSYFKYINRQSSFFAVEKMTYKPWELMFLAGISLNQISYDREDLFAMPGLFMINGTDMYNKNLSFSKKFDLVATPHFALQKSWRNQIFNLSYSEGYNAPTSATAFIAGLSKTNDNLKAERAKMWDFSIQGLFADTAIDYQFSVFSINIEDKLTQLRATLANAENTAYSYWANTGNQQNRGLEMSFGYVYKPRNSFVTNIQPFVSYTYSDFKYTSFNTYLKEHDSPAAVMNYDQNIVPGVPKNRLALGFDIETKAGLYLQNTYNYMGSVYTDFANSNEVKSFGLFNSKIGYKRSFSRFEFDIFAIGNNLTNQINYTFLFYGNSINDTDQDNQYNDPSVYTDVNPGPSKAYFFTGFNAKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4T7</accession>
    <name>C6X4T7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <shortName evidence="2">Tpx</shortName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peroxiredoxin tpx</fullName>
            <shortName evidence="2">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpx</name>
        <name evidence="4" type="ordered locus">FIC_00974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782571.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00974"/>
    <dbReference type="EnsemblBacteria" id="ACU07425">
        <property type="protein sequence ID" value="ACU07425"/>
        <property type="gene ID" value="FIC_00974"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00974"/>
    <dbReference type="eggNOG" id="COG2077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_12_2_10"/>
    <dbReference type="OMA" id="ITQEPNY"/>
    <dbReference type="OrthoDB" id="1738458at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="165" mass="17963" checksum="C98134DF46EDE824" modified="2009-09-22" version="1">MAEITLKGNAVQTIGQLPEIGLSVRDFALVNDKLEVKTLADYDGKKKIFNIFPSIDTGICAESARKFNEKAGELDNTVVINVSKDLPFALGRFCAAEGLDHVESLSDFRGTFGDDYGVTMMDSPMKGLLSRAVIVTDETGKVIYKEQVPEIAQEPNYDNALNALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X8</accession>
    <name>C6X4X8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ordered locus">FIC_01016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782612.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01016"/>
    <dbReference type="EnsemblBacteria" id="ACU07466">
        <property type="protein sequence ID" value="ACU07466"/>
        <property type="gene ID" value="FIC_01016"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01016"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_10"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="OrthoDB" id="662268at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="360" mass="39485" checksum="3916ACCD9B1CDF72" modified="2009-09-22" version="1">MNKKLILESGEVFRGQSFGIDQEIEGEVVFNTGMTGYQELLSDLSYCGQIVCMTYPLIGNYGINRDDYESINPAIKGLIVKEISDYPSNFRSQMDLGEFFQKKNLSGISGIDTRRLTRVLRNSGVVKGKIVNEDADESLVIADLKASVIPTDQVAQVSTKTSYANPGRGLKVVLVDFGSKLGILRELAHRDCDVIVVSQDTTAEEILLINPDGVMLSNGPGDPEDVKGATEMIQKLLGKVPIFGICLGHQLIGLACGAKTFKLKFGHRGGNHPVLDLAKNKVAITSQNHGYAVDQESLLNTDLVETHIALNDRTNEGLKHKIHPCFSVQYHPEASPGPEDANYLFDEFIVLMEQFKNVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X550</accession>
    <name>C6X550_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805823.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01088"/>
    <dbReference type="EnsemblBacteria" id="ACU07538">
        <property type="protein sequence ID" value="ACU07538"/>
        <property type="gene ID" value="FIC_01088"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01088"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278452_0_0_10"/>
    <dbReference type="OMA" id="FGTTNTH"/>
    <dbReference type="OrthoDB" id="53190at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1099" mass="125321" checksum="A1BD8734E7DE4337" modified="2009-09-22" version="1">MAKVFRLFDDIDVQHWENTNQIGPAQINTIGDVSGGIMSKDPTSIPSPFARMDLAKSAFKNVVDLKNVDGQTVFNKIVSDNFDLMELLFHSNEIGGIEITSWDANQSVAHLIGSNNRKHRLLGKTLQLFINQDRIFVDNPKIFIFSRNHKILGGTSPLSVVFTTGNSLRDTNIQLTERALFTSPYQPLYKRDADFQKYVYSLVYNNTAFGNKFLELKEYLDYSLKILDNDNHSLYLELQNIKLDQNFYSNTFAELNGSVDGNTVTLFNIPLRKSKGTVLESDFFIDTNLPQPNGIPLILQNEYTLPLNYIGTTRWTENNINVPFNDERALHERTLPGLIKKYPYKTVDDFLEPVIFRLPYELDSAKFLSVSAVENKSFLLPLKSTFFKYFTTDDLLNRRVGGQPMLSMEVLQNSVTVQLRIPIKKQGHYITLSRKYKVDGEIDISRNIGAVKNLFMNVGVSPFLQLENSDASDHYRIGLFNMIDRGVNLSFSYQGKATPVENSYVRTSEVFFSSRYFVLNHKFDAVKVEFDGYSALLIPKLRKQSEGPRSFTFGVDFGTTNTHIEYKEDQGRPIPFTIHPEDLQTVYTISNISQSNIEVSRLTELKKLSEYEYIPEFLRGDLNEFPIRTVISNSAKLGVADVKFSLSQMSIPFNYILEDSLESNTYTQNLKWGSNQVDALHADKIRLFLDELFFLMRNKVLTNNGNLSSTKIHWSYPLSMPIRQISDLENFYTNLYKKYISSTQSTSNVKKYNESIAPFEYLKTEGGLVAFTKPVALLDIGGGTTDIVIYKNNNAEKITSFRFGANKIYSNSNSGIHGNGFTKEIEKFKEGNNLSPIFLSILNKFMTSENMTEGISLLFSADTNIRHKDTVSNKFSDQLRSNENLKSAYVFYYAAIVYHLAKFMKANNYDMPAKIIFSGNGSKILNIIDNNDSAPILTKISTYVFDKVYEATGSNLISIEKRNNPKEMTAKGLTYTNNFAQDINEMKSTLLGTQDNTLLNYNSSVTYETLNNKDAQSVNAEVNDFIDLFVEMYSHLNTEYFDVDAQLLKGFKETLSRDTLNYIMKGIEENKGNDLKITDSLFFYPLENSLYQFVQYVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X559</accession>
    <name>C6X559_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805832.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07547">
        <property type="protein sequence ID" value="ACU07547"/>
        <property type="gene ID" value="FIC_01097"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01097"/>
    <dbReference type="HOGENOM" id="CLU_398294_0_0_10"/>
    <dbReference type="OrthoDB" id="2125211at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="631" mass="75049" checksum="B7DE0BA42C9C277E" modified="2009-09-22" version="1">MDEHIENKIEYWQDLWHHLIDNFLKKSYGLNLYNVHILLEDIIVEIEENNFRNDENRKFFKGKLDEYFSTDKTLSELFYSDFKYLCRIFHEPNKNNLIYTISKDILTKFQKGLYFTKCLENLIEILFNHLSLGDTLKEINYYTQNIIIEFIKKGYVLKDIKKFTDKIFDNYQIINNGEEDILVTTYPHNISYSDYKVDGQIDRENLNLAISNVISNLTLKDRIQEFINIYNKEREEAYYIFVIQGLRGDQGFEIGDIAFYSPSQKRFAVNDNFDDEELQSDKDDKYIQAAVKVDFLASESSLAIAISKLQNAINLLHTYYDTKIEIEIITSKYLVIKDGIIINTSWSNNNNDFIKLHKSLRINRLHKRLAELDKYKILFSSQSDETASTLLNAIHWYSKGENSLKPEDKLLNYWISIENIINSEFENIKNDIQTKNKKKIEIIQSIVSSNYIFNFIYEFGWEYYNHYSVIAHNKLFNKTGLPDNLIEKANLVTKEGEPIYLQKFVESLPEIKDFETNLFLKEKIENLIDFYNNNNYSATIIKQQIKSVEDDLLMTYRYRNLIVHNAHFDNAMLPYYIWKIKDYSGNLIRNLLYRFEKTDDNLSTLLFNIYIEKEKFLIDLKDNKAKLFMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X570</accession>
    <name>C6X570_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01108"/>
    <dbReference type="EnsemblBacteria" id="ACU07558">
        <property type="protein sequence ID" value="ACU07558"/>
        <property type="gene ID" value="FIC_01108"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01108"/>
    <dbReference type="eggNOG" id="ENOG502Z9VN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042391_0_0_10"/>
    <dbReference type="OMA" id="LMIMFTT"/>
    <dbReference type="OrthoDB" id="1334916at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="530" mass="59199" checksum="844992CE590131F0" modified="2009-09-22" version="1">MVISCRNTAVKKLNGNSSILPKTCVMKTILSYLPFITAVFFALLFGYAAFSKGMDFQNFQVQLAQSPLLSAWAGFVSYAVIIVEMVVVLLLCFDRTRLLGLHASFGLMVAFTVYITLILNYSDFVPCSCGGVLEKMTWDQHLVFNIVCVLMALAAIILMEKAMARGWNRPAALLMLTGVLSAGGMVALFLSSEHIIKKANNFTRRFPHHPIREERAYDLKVNSYYFAGSSGNTIYLGNSSTPFRILRMDHSLQKSDTLDLEPATNHRFSNLTYTVQDGMLYAHDGTVPVIYSSPVDSLAKPLREISSKDIYFDKLAAVSPKEFLLRVQDAKSDRLSVASLTVGKPAVVKVNSSALTTNADGGFDADGELLYDSAAGFAVYMFYYRNQILHFNKDAQLTGQKKTIDTISNADLKILTLPDGKRKLSEPPLHVNRSMTFHHGLLFNESGLMGRHESRAQWRKNAVVDIYTTSPAGYWGSMYVQHRGAHRMSQMLVTDRYFFVLAGDEIVRYRFAQTVAQAFIKRGSRKPFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X581</accession>
    <name>C6X581_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na+/H+-exchanging protein (Na+/H+ antiporter)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805854.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01119"/>
    <dbReference type="EnsemblBacteria" id="ACU07569">
        <property type="protein sequence ID" value="ACU07569"/>
        <property type="gene ID" value="FIC_01119"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01119"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_2_10"/>
    <dbReference type="OMA" id="MFVIGME"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="69"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="759" mass="84033" checksum="7442EFA6967CF304" modified="2009-09-22" version="1">MQKYRNIIFYVTTLLFFSGIMYWFISMGRELDTPGANAGTFAPVSVWDSFVVSLGENLRHPLALLLLQIVAILLTARLFGWICVKMRQPSVIGEMIAGIALGPSFLGMHFPEFSGFLFPSESLGNLQFLSQIGLILFMYIVGMELDLKVLRKKAHDAVVISHASIIIPFTLGIGLSYYIYREFAPDNTSFISFALFIAIAMSITAFPVLARIVQERNLQKTKLGTVVITCAAADDITAWCILAAVIAIVKAGSFGSSLFVILMAVAYVFLMIKLVRPFVKRVAELQTGKGLMSRSVVAIFFLILIISSYITEVIGIHALFGAFMAGAIMPENTKFRNLFIEKIEDVALVLLLPLFFVFTGLRTQIGLLNDAHLWQTAGLIIAVAVTGKFIGSALTAKFLRISWRDSLTIGALMNTRGLMELIVLNIGYDLGVLSPEIFAMLVIMALVTTFMTGPALDLINFLFRKTPATPDEEDDAETSRYKVLLSFVEAESGSSLLRLADNLTHKMNGNKSITAMNFAPVNDLHTFAADDYEKQQFGDVLHTAHQLKTAVTTLFKVSNDMESDIISITKKGNYDLLLIMPGGSIFEGTLLGRLLGFTTNIINPGKLLDTVTGRANLFNLSPFDAATLSILDKTQTPVGIMIDRDFRSADKVFVPLFDLNDFYLLEYAKRLINNNDAQIVILDAGGQIRKNVEIRELIRSIEQMAPNHITLRADRSIEKAFLDSQDLMMISRRSWQTLVDSKSLWLSDVPSTLIVSHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X592</accession>
    <name>C6X592_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07580">
        <property type="protein sequence ID" value="ACU07580"/>
        <property type="gene ID" value="FIC_01130"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01130"/>
    <dbReference type="HOGENOM" id="CLU_3328170_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="38" mass="4482" checksum="A6F9BA50CFCF13D1" modified="2009-09-22" version="1">MPWLAGFIGKTYIIKEQRKKTDRSPLSLKSHFLDPYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5A0</accession>
    <name>C6X5A0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805873.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01138"/>
    <dbReference type="EnsemblBacteria" id="ACU07588">
        <property type="protein sequence ID" value="ACU07588"/>
        <property type="gene ID" value="FIC_01138"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01138"/>
    <dbReference type="HOGENOM" id="CLU_506015_0_0_10"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="538" mass="61152" checksum="0C81DFA8EE2C882E" modified="2009-09-22" version="1">MIGMNNFGSKPGDFVAGARQQKCPSVRCNFLHLICPTNYTIEMKFKLLLLLSLLFTLFISCNRDDTSSDIENSIELSISTFTATSVTLNYSIKNISGDKYLIYSKSESFDILNYEQKILLNNSNNIQINDLTPNTKYFFKIAYSENNSFTYSNVVSAITKEVSFLKILDKDIGLIPDSGSFIYLMDSELDESKSFLFLLTRQIKQYGDVKKITLHKVDLNGNLIWSKLIQDSPSPYTYEIQLLSDGNIAVLTGKSNQKSTIVTKLNPINGSIIWQKEYPVIDLNGMQGNFMLAYRYQNNLMKILTSGGAELEELWLNNDGAVISHKTIKANNIVINKATYSEDGDLLDIFKGDKIPSDGSATFDGLIQKFSITDGIATKLWSRYYGDDGGDDLFENYVLKNNNIYIQGYYGGTSGFDDPKKWILKLDMNGEILWQNKQSSRKDFIYQGTDIKVNENNELFCLTHEIYYPNYNAYDYTTLTKFDSNGNLIWMWKSAEDFNTERFSSNKVFETNINEFIITGKKSGGVGSIWIKKIKVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C1</accession>
    <name>C6X5C1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01159"/>
    <dbReference type="EnsemblBacteria" id="ACU07609">
        <property type="protein sequence ID" value="ACU07609"/>
        <property type="gene ID" value="FIC_01159"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01159"/>
    <dbReference type="HOGENOM" id="CLU_1064571_0_0_10"/>
    <dbReference type="OrthoDB" id="1827225at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="261" mass="29552" checksum="07B566AAE88A1F6B" modified="2009-09-22" version="1">MIDKNFYLENLTAFDVLIGADRIEAEKAIFKVYCILQRDKYWLNNVATPEEIGEEDAELLEGVELELKELDQEHGFRFADFHELVMKEIETGGSGIAAIAEQDDDLLGFGDDDEDFDEEDEFEDDDDDEFEEDTSNKMGDFTDEELNLVVDYILNSAKKSFGYDQFAASFPDATMEFIDDQVLLYIIARKAYGEPDEEIAVTLAETFELNGFEIENEELLALTTKLGKDFSKEILAFGIAMDSLQQGTHPVDVVAHISNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5G3</accession>
    <name>C6X5G3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional deaminase-reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805936.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01203"/>
    <dbReference type="EnsemblBacteria" id="ACU07651">
        <property type="protein sequence ID" value="ACU07651"/>
        <property type="gene ID" value="FIC_01203"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01203"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_2_10"/>
    <dbReference type="OMA" id="GYIAKPN"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="177" mass="20157" checksum="0967E02C886FD884" modified="2009-09-22" version="1">MRKTSLFIATSLDGYIAKPNDDLSFLKLVDKEGEDYGYAEFTSTIDTLIVGRKTYDYVLKEIGSSHYDNGQRDVYVITRTEKPQVGRTIFYTGKIDDLVKQLKSEKGENIYCDGGAEVINELLKHDLIDNLIISVIPVLLGNGTRLFKDGRPEQILEFIEAKTFEPGLIQLHYERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I4</accession>
    <name>C6X5I4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07672">
        <property type="protein sequence ID" value="ACU07672"/>
        <property type="gene ID" value="FIC_01224"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01224"/>
    <dbReference type="eggNOG" id="ENOG50343VD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459268_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="21133" checksum="9051E4CBA0DB1BAA" modified="2009-09-22" version="1">MCNRMKTIPITILFAFITILLGCSKESKTIKEDDEKILINAKEILENKNLAGLITKLENTELTEETDINKIPKVILNFLNAILEDKPIANPHENWNPTDVILDKKLPRRKLQYFGSGKNIALMNYFKGGIGKSTIILIFEFNEKKVTNFWCGSVLVDLNNKETTLKYLKANINKERGLNTNILSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K4</accession>
    <name>C6X5K4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805977.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01244"/>
    <dbReference type="EnsemblBacteria" id="ACU07692">
        <property type="protein sequence ID" value="ACU07692"/>
        <property type="gene ID" value="FIC_01244"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01244"/>
    <dbReference type="eggNOG" id="ENOG5033BP4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192201_1_2_10"/>
    <dbReference type="OMA" id="LNCDEYE"/>
    <dbReference type="OrthoDB" id="2014968at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022037">
        <property type="entry name" value="DUF3606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12244">
        <property type="entry name" value="DUF3606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="60" mass="6821" checksum="0518F66858F3A9B7" modified="2009-09-22" version="1">MADNKNKSGEPDRSLINTSERYEMDYWTKKLGVSDEELKRAVKAVGNSAEKVAVYLKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q7</accession>
    <name>C6X5Q7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01297"/>
    <dbReference type="EnsemblBacteria" id="ACU07745">
        <property type="protein sequence ID" value="ACU07745"/>
        <property type="gene ID" value="FIC_01297"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01297"/>
    <dbReference type="eggNOG" id="ENOG50349CI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701602_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="393" mass="45905" checksum="A47D88C6840C2994" modified="2009-09-22" version="1">MMINQLRREFQEIYFNNISTTKGLEELAKNIGISKNSLRRFLQKIKDDTTLRVSTLTLIAQQLGYKDYADFCDSIGRQKYSLDFELLDIYYGIVKGQGTTLNETRFQKANYYFAQKIISDPLNLKEFVKRFADNYEALEYVLAWHPSYENIANSNYQAALLQLARSSPKAHIKVFAYSFVVFGKFMSEKLAVSEAKELIAKIEKYVYKMREEEGEFHAFPEARYVIAKTIYAYLTGTDAKSRRPDAALQRLIGLQHISASPIDKIIFGTYVTNILNILHDYENADLCLGELLSEKTLLKIKEENPHLSTHIFLYKLNWVITQFHLGRKDEALLVFETLPSDLIKVHTSSFDSKIYFELKYLYFARSLYPKRQDIKRRFDFLVEKTQFTFLHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R8</accession>
    <name>C6X5R8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806041.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01308"/>
    <dbReference type="EnsemblBacteria" id="ACU07756">
        <property type="protein sequence ID" value="ACU07756"/>
        <property type="gene ID" value="FIC_01308"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01308"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047829_0_0_10"/>
    <dbReference type="OMA" id="NERWFAK"/>
    <dbReference type="OrthoDB" id="1463166at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970711" evidence="1">
        <location>
            <begin position="19"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="424" mass="47915" checksum="2E63B7E922D0E3C7" modified="2009-09-22" version="1">MKRIFVLPLVSAGFFLNAQTIGNSPYAAFGIGDVKYDNTTDINAMGGISTAYIWDFNNSFNFSNPAANKNLDLTTIKVEATNENNFFKSDFDNSNVTKHSSYLSNLSIAFPLSPKVKFGLGYQPYSSKKYSVIVQDDLPENVTRANLFRGEGTISTMQAALGYQISPEFALGLRTNFYFGNLFDINEIAYTNAELINGYETKNKIKTFNFTLGTAYQKRYGLDRKLTLGATYTFGSTGQMETQYTNSTYFYGNGDTRNNVSIIDEDFSTDKNLIPMEFSLGAGYGRDAKWFLGTQFDYKKGETIQFLGQPFSNENSYRIAAGGWYLPNYNNFRSYFSRVTYRYGAYYEKGNLSFNGTNINQFALTGGVTFPFENRSASRMSGIDVGVELGKRGTLENNMIRQNFVNFRIGLNFADKWFQKRLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S3</accession>
    <name>C6X5S3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Curli production assembly/transport component CsgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01313"/>
    <dbReference type="EnsemblBacteria" id="ACU07761">
        <property type="protein sequence ID" value="ACU07761"/>
        <property type="gene ID" value="FIC_01313"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01313"/>
    <dbReference type="eggNOG" id="ENOG5032EF8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096116_0_0_10"/>
    <dbReference type="OMA" id="FYLEANQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018900">
        <property type="entry name" value="Curli_CsgE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10627">
        <property type="entry name" value="CsgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972353" description="Curli production assembly/transport component CsgE" evidence="3">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="240" mass="26882" checksum="E4D3595A41AFEE07" modified="2009-09-22" version="1">MKMKTLITTLVVVFLANKSIAQVNEQVSGKIITENKEGTLKIKAAAISSSETYLSLNYIMVSVKKGKSGNSTNKQSGKFSLGPKETKTLSETALNLAKNDALKVYLFVKDEETDAVLSKDSLEINAEKFASEVNYIPENRIELSGLTIDDTKTRFGQQFYETFFKKYNQLPQKYEGTVTVSELPSMGRNSRISVSLDDQVIYTFITRPADEAMDAEADRTMALLADYSKRNAVRDQQFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5T3</accession>
    <name>C6X5T3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensory transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01323"/>
    <dbReference type="EnsemblBacteria" id="ACU07771">
        <property type="protein sequence ID" value="ACU07771"/>
        <property type="gene ID" value="FIC_01323"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01323"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_6_10"/>
    <dbReference type="OMA" id="LTNAKRH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="259" mass="29755" checksum="35A98072EB2EC80A" modified="2009-09-22" version="1">MQLQLSSTDIIFILSTVIIVIVLLILIVIYGVFIKKKSELLLIQQKKEAIFEQELARSQEELQNQTLKYIGQELHDDLGQKLSVARLMTNKIAYAPESDHTQIAEEINLLVGECLQDIRNLSKSFIGQNNDGFNFIESLEREVYRMKRLALLEVDYKINQQNLKFNAEHGLILFRIIQECITNVIKHSRSKSIQLVVEDHPRYTKFRIKDAGVGFKSARHTDGIGLKNMISRAKIINAELKINSIENKGTQVTLTYKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U3</accession>
    <name>C6X5U3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806066.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01333"/>
    <dbReference type="EnsemblBacteria" id="ACU07781">
        <property type="protein sequence ID" value="ACU07781"/>
        <property type="gene ID" value="FIC_01333"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01333"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124949_0_0_10"/>
    <dbReference type="OMA" id="GHRLILW"/>
    <dbReference type="OrthoDB" id="1822108at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016769">
        <property type="entry name" value="Phage_SP01_Orf1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020079">
        <property type="entry name" value="UCP020079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="143" mass="16513" checksum="7482351C71023342" modified="2009-09-22" version="1">MQSNKKLAIDFDGTVVEDAYPGIGKPKTFAFETLRKLQSEGYRLILWTYRHGKTLDEAVEFCRKNGVEFYAVNSSFEGEIFDCDTASRKIDADLFIDDRNLGGFPGWGEIYNIIRDRIEFRVEGSEVLAYSKMKKDKKKGLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V3</accession>
    <name>C6X5V3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806076.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01343"/>
    <dbReference type="EnsemblBacteria" id="ACU07791">
        <property type="protein sequence ID" value="ACU07791"/>
        <property type="gene ID" value="FIC_01343"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01343"/>
    <dbReference type="HOGENOM" id="CLU_1852217_0_0_10"/>
    <dbReference type="OMA" id="CEGFYGY"/>
    <dbReference type="OrthoDB" id="1962311at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="138" mass="15651" checksum="492B005AE0385E65" modified="2009-09-22" version="1">MRNIFKFCIPVVMALTLTNCNDRLEGDEIVSTEPLKIDSVKIAQDTMDVFSTQTIKTYSTYSAQCEGFYGYDYAHVAPLQREVATYKFKTSATCGDEVPRASQINFRPQETGIYTFRFWTGEDSAGEGIWLEKTIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W2</accession>
    <name>C6X5W2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01352"/>
    <dbReference type="EnsemblBacteria" id="ACU07800">
        <property type="protein sequence ID" value="ACU07800"/>
        <property type="gene ID" value="FIC_01352"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01352"/>
    <dbReference type="eggNOG" id="COG4121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061971_1_0_10"/>
    <dbReference type="OMA" id="LIYFDAF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016645">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008471">
        <property type="entry name" value="MnmC-like_methylTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05430">
        <property type="entry name" value="Methyltransf_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_30" evidence="1">
        <location>
            <begin position="148"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="233" mass="26908" checksum="9410C9B34B6239FB" modified="2009-09-22" version="1">MKKNSMDRETKMTNDGSKTLHIKELNENYHSSHGALQEAMHVFIDNGLNLVEKCEINILELGFGTGLNVLVTIDEFLKTDKNHIIHYFTVEKYPVNDGEVRELAYEKLFSNPDMKFYNDQVHSCDWNASTEILPNFFLTKFQCDFFEIKSLSLPQIDLVYYDCFGARVQPDLWEKPLLQTVADKMADGALLTTYSSKGSVRRILKDLNFTPEKRQGPPGKREMMIAWKVQPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Z5</accession>
    <name>C6X5Z5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucyl aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01385"/>
    <dbReference type="EnsemblBacteria" id="ACU07833">
        <property type="protein sequence ID" value="ACU07833"/>
        <property type="gene ID" value="FIC_01385"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01385"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_6_0_10"/>
    <dbReference type="OMA" id="DVHNTGG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="161"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="472" mass="52554" checksum="E83D9BC0700AABD6" modified="2009-09-22" version="1">MINIQISNKLSENHRQEFSFFTESSWANLNETFNNIPPAHFSAKKDETFVAVLNDVVHYFIGLGKDPQNFEIQATASKFSNDFRKKIQSQDTLLNMANLNEGQIKSIIEGLYLGTYNYPFKGDHPFFNLKFTLVSDALNEEDLQNLQQRTKALCEGQFTCMEWLNKPQNHKRIPQITQFFHSVAEKYGLKISVFDRQKCLELGLGAFLAVNQGSSQDAAFTVIEYNCGRTDAKTVGLVGKCVLFDTGGISIKNSENLHYMKSDMGGATAVIGTLISAAELKLPVNIIAVLPVTDNAVSNEAYLPSDVVKAYNGKTIEVLDTDAEGRMTLADGLSYLAKNYQTDALIDLATLTGSSVRMFGGTCAAYFSNNAELRQALEKSGDLTNQRLWNLPLWDVWKDEFKSDVADFKNISLKPYGDCIVAAKFLEQFIEEHASWAHLDIAGTAFGNVPYMKEKGATGYGVQLLVNFLENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X601</accession>
    <name>C6X601_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806124.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01391"/>
    <dbReference type="EnsemblBacteria" id="ACU07839">
        <property type="protein sequence ID" value="ACU07839"/>
        <property type="gene ID" value="FIC_01391"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01391"/>
    <dbReference type="eggNOG" id="COG2308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703380_0_0_10"/>
    <dbReference type="OMA" id="RIYNRVI"/>
    <dbReference type="OrthoDB" id="386421at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="395" mass="45789" checksum="A00C4C30A192AB83" modified="2009-09-22" version="1">MIPKYRARFNAEFSPEKYAELFADLKQKSGTDAAFRVAESPVFLTMDFKAKLQEACDSIITQIKEMPAEELRKAIPQSEMVPNDTLQPHFFTIDFGICTNADGEVVPQLIELQAFPTLYSFQKELQNSFIKIYPFLEELKPKISDEAYYADLKELIVGDENPENVIILEIYPEKQKTLIDFLLTGKKLGIKTVCLTKVNKSGRKLYYDNNGRQTEIKRIYNRVIFDELSRIPDLKLAFDFRDELDVKWVTHPNWFFKISKFLLPKLNHQYVPTSYFLNEFPDKANLEEFVLKPLFSFAGSGVNLNPTAEDLRRIDDPENYILQKKVSYAPLFEDTEGNFSKAEIRLLYIWKENEERPILMEHLVRLTKAAMVNVDFNKKDAIWIGGSTAYFAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X651</accession>
    <name>C6X651_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01441"/>
    <dbReference type="EnsemblBacteria" id="ACU07889">
        <property type="protein sequence ID" value="ACU07889"/>
        <property type="gene ID" value="FIC_01441"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01441"/>
    <dbReference type="HOGENOM" id="CLU_3328171_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="38" mass="4248" checksum="632F76519E028937" modified="2009-09-22" version="1">MQRHPFFVAEAPEATKKDTAESGYHFVPGKNFVAPQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X660</accession>
    <name>C6X660_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl peptidase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01450"/>
    <dbReference type="ESTHER" id="flab3-c6x660">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.013"/>
    <dbReference type="EnsemblBacteria" id="ACU07898">
        <property type="protein sequence ID" value="ACU07898"/>
        <property type="gene ID" value="FIC_01450"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01450"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_2_0_10"/>
    <dbReference type="OMA" id="MRTPQEN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="90"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="524"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="716" mass="81202" checksum="5FCE8AF6C8BC5258" modified="2009-09-22" version="1">MKSYQNNFMNKIFLSVSLIASVATFSQEITLDKIYSGYYRGKGISGIASLKNGENYAVIEPAGIAKYSYKTSQKEGNIVDGSFQSYIFNEDESKVLLLKDSEPIYRHSFLGKFDVKDLKSGKVLNLNNGNFVQEPGFSPDGSKVAFIADNNLYYQDLNSGKITQITTDGKKNYILNGLADWVYEEEFGHAKLYEWNKNSDAIVFVKSDETEVPEMYIPIYGKQLYPSEMRFKYPKAGEKNSVVSAQLYRLDSGKTTSLDLSAFKNYYIPNVYKTAKADEIILITSARTQNASDVLKVNTKTGNVRKLFTETDEKWVDTDNVTLEFLDDNSFIWGSERDGNRHLYWYDQDGKLKKQITKGNWEVTDYYGFNPKTKEVLIQTTEKGSINKVVSKVNINTGKSTLLSNSEGNNRASFSGNYNYFIETSSTAARPFTYILKDGNGKTVKELQNNNDLLQKLQADNMATKEFLTVPNEAGDQMNAWIMKPKDFDPNKKYPLFMFQYSGPGSQSVSNSWDAGNGLWFNHLVQKGYIVVCVDGRGTGFKGTKFKKSTYMNLGKYEIEDQIAAAKWFGNQSYIDKSRIGIFGWSFGGYMASLALTKGADVFKTGIAVAPVTNWRYYDTVYTERFLRTPQENPKGYDENSPTEYADLLKGKFLLIHGTADDNVHFQNSVEFSEALIQNKKQFEFMAYPDKDHGIYGGQTRPQLYQKMTDFLLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C8</accession>
    <name>C6X6C8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806251.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01519"/>
    <dbReference type="EnsemblBacteria" id="ACU07966">
        <property type="protein sequence ID" value="ACU07966"/>
        <property type="gene ID" value="FIC_01519"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01519"/>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_6_0_10"/>
    <dbReference type="OMA" id="PMISGSG"/>
    <dbReference type="OrthoDB" id="1560952at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="454" mass="49814" checksum="983116E968670105" modified="2009-09-22" version="1">MLRFLVYIRRGIKKAFDNLQNEKFKYNLLQAIPFWIGSIITGVLAVIYAKLFTWGETLMNAIFEWNALLIFIIAPVCFVLSWWLVKEFAPYAKGSGIPQVMAAVELANPKEHYKIPYLLSVKIIVLKILSSLILVIGGGAVGREGPTIQIAGSVFRKVNEYLPDWWPKISKKNMIMTGAAAGLSAAFNTPLGGIVFAVEELSKTHINYFKTALFTAVIIAGLTAQTLAGSYLYLGYPKTSGVALTIMFPVILVAGISGICASQLSVFMIKITAWKKNLKTQKAHIIFLVISALIIASLAYFVNREILGSGKEIMERTLFTDDKHEDWYMPLFRMIGPALSFTSGGAGGIFAPALSAGASIGSVISGWINLTPNETNVVILAGMVAFLTGITRAPFTSAIIVLEMTDRHSLIFHLMLAGMVSSLISLIISRKSLYDSLKINYLSELRSETIKKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF1</accession>
    <name>C6WZF1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycoprotease family exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00008"/>
    <dbReference type="EnsemblBacteria" id="ACU06486">
        <property type="protein sequence ID" value="ACU06486"/>
        <property type="gene ID" value="FIC_00008"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00008"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_1_0_10"/>
    <dbReference type="OMA" id="PFYLKDF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="50"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="26631" checksum="6C692695C378D790" modified="2009-09-22" version="1">MNGRFLPPNIQHDMKILHIETSSRNCSVAISDGDELLCLCEEVSENYKQSESLHTFVEWALEGAGIALNDLDAVSLGMGPGSYTGLRIGSSAAKGFCYGLQIPLIAVNSLETMIEPFLDQNFDFIVPLLDARRMEVYTAHFDGNSGQMLTQTEASIIDQDSFQEFLGKKVVFVGDGALKAKGVLQLPDAEFNSDVYPSAKFLIKKAVEKFRNKDFEDVAYFEPFYLKEFQGLKKKKTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF5</accession>
    <name>C6WZF5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ordered locus">FIC_00012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00012"/>
    <dbReference type="EnsemblBacteria" id="ACU06490">
        <property type="protein sequence ID" value="ACU06490"/>
        <property type="gene ID" value="FIC_00012"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00012"/>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_1_0_10"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="226"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="311" mass="34951" checksum="777CABFB7A993044" modified="2009-09-22" version="1">MNSPITNSMRSIKIGTRNSPLALWQAREVARHLQNNNHTTDITPIISKGDKNLSQPLYTLGITGIFTKDLDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQLKIATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGLSVDYEHLPLMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGGCTAPIGAFAEINDLGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGRELMQEIKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZI5</accession>
    <name>C6WZI5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrofolate synthase</fullName>
            <ecNumber evidence="5">6.3.2.12</ecNumber>
            <ecNumber evidence="5">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="5"/>
    <dbReference type="EC" id="6.3.2.17" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781667.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00042"/>
    <dbReference type="EnsemblBacteria" id="ACU06520">
        <property type="protein sequence ID" value="ACU06520"/>
        <property type="gene ID" value="FIC_00042"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00042"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_1_10"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="4">
        <location>
            <begin position="54"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="412" mass="46208" checksum="B93A74B65D3A635D" modified="2009-09-22" version="1">MTYSEYQDAVAWLFAQVPNYQTDGKTAYKPGLENIIALCEHFGNPQRKIKTIHIGGTNGKGSVSNMLASVLYEAGYKTGLYNSPHLIDFTERIKVNGKTCEKEFVFEFIQKLKDLPAEITPSFFEFTTIMAFEYFHQQNVDIAIIEVGLGGRLDSTNIISPMISAITNVALDHQDILGETIEEIAFEKAGIIKDGVTVISGAEDETVRNIIRSTAQQKNSRFVDAGTIQSELKSDLKGDYQQKNIKVVVALVDQLRESGLNVTAKNVERGLLKVHQNTGFIGRWFEFSSEPLIICDTAHNQAGLQAVFAQLESIPKHKHIILGFVNDKKIDDVLGILPRNSTYYFAKPKVNRGRHPLDYEDLLKNSKINYKIFDEVQLAYVSAKQNIKNNEMIFIGGSNFVVGEFLENNLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ5</accession>
    <name>C6WZJ5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781677.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00054"/>
    <dbReference type="EnsemblBacteria" id="ACU06530">
        <property type="protein sequence ID" value="ACU06530"/>
        <property type="gene ID" value="FIC_00054"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00054"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_5_2_10"/>
    <dbReference type="OMA" id="PNCESHQ"/>
    <dbReference type="OrthoDB" id="422804at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="436" mass="50171" checksum="3E145D87D7F47D3C" modified="2009-09-22" version="1">MALLDNITSNHPAFLETLKHRFLDENRVFALQNFLQMGLPTKKDEEYKYTNLREITEKSYNFFPKEAHNISKEKIEELHLGEENFDWIVFVNGVLHKELSKISIENVEFLSFNYALNDPKHKEVFEHYFNTIAAKDLAFTNLNTAYCKQGFFLKVPKNVVIEKPVHVFYLSQNQDENTIYNTRNLLIAEAGSKVEIIESHHNFDETFVLTNTVTEIFTYENAKADWHKLQNDSDHSYMIDHTFAKQERDSRTTVNTFTFGGKLVRNNLDFIHNGENINSYMNGITIIGKEQLVDHHTAVHHKTPHCESYQNYKGIYKDKSHGVFNGKVFVDKLAQKTNAYQQNNNILLDEGATIDTKPQLEIFADDVKCSHGCTVGQLNEDALFYLRARGISKKEAQALLLFAFASDAIQNIDIEPLKVKISRLLASKLGVASEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN1</accession>
    <name>C6WZN1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781713.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00090"/>
    <dbReference type="EnsemblBacteria" id="ACU06566">
        <property type="protein sequence ID" value="ACU06566"/>
        <property type="gene ID" value="FIC_00090"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00090"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_1_10"/>
    <dbReference type="OMA" id="QVWPGHG"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="268"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="372"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="468" mass="51522" checksum="6F7409575F6AD392" modified="2009-09-22" version="1">MKIEQIYTGCLAQGAYYIVSGTEAAIIDPLRETKPYIERLQKDGVTLTYIFETHFHADFVSGHLDLSKKTGAPIVYGPTAEPDFDAIIAKDNQIFEVGKIKIKVLHTPGHTLESSTYLLIDENGKETAIFSGDTLFLGDVGRPDLAQKSAHMTQEELAGMLYDSLQSKIIPLADDITVYPAHGAGSACGKNMQKETVDTLGNQKKTNYALNQPDKESFVREVLDGLSAPPKYFGMNVALNKGGYDSFENILEKGNTPVSVTDFEKIAEESGALILDTRSAADFHKGFVPNSINIGLKGDFAPWAGAMIVDVLQPILLVCDTGTEEEVITRLSRVGFDNVLGYLEGGFDAWKTSAKETDTVKRISPEKFAAEFNEDSKVIDVRKETEYDAEHVDNAFRRPLAEINEWVNSLNNDEHFYVHCAGGYRSMIAASILNSRGIRNFTEIDGGFNKIKETSVPKSNFVCADKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN6</accession>
    <name>C6WZN6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781718.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00095"/>
    <dbReference type="EnsemblBacteria" id="ACU06571">
        <property type="protein sequence ID" value="ACU06571"/>
        <property type="gene ID" value="FIC_00095"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00095"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_0_0_10"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="181"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU06571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="445" mass="50121" checksum="6D80C512C5F43053" modified="2009-09-22" version="1">MTLIQLFQFILSISILVVLHELGHFIPAKYFKTKVEKFYLFFDPWFSLAKVKFRGTEYGIGWLPFGGYVKIAGMVDESMDTEQLKKPAEPWEFRSKPAWQRLIIMMGGVTVNFFLAWFIYSSLSYFKGETYHDNTKFENGIAVSDAGRKMGLQTGDKILRIDGKKADRMETSTVNMLFADEVTVERNGKEVTFPVNELGVADVLAGNQAKAYFTPRFAVVVDSLFPNGTAKAAGIIKGDRIMAVNGTPVKFFDEFSAELLKYKNQDITLTVQRNNAVQQLPTKVNPEGKIGFATDVKVAQAELSKARVTKNYTLLEAIPRGLTRTIDVLTMQIKQFKIVFNTTTEGYKKVSGPIGIIKQMPETINWEFFWGFTAMFSVWLAFLNLIPIPGLDGGHVVFTLWEIITGKPVPQKVLENAQMIGVIFLLGLMVLIFGNDILKWITGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZP7</accession>
    <name>C6WZP7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00107"/>
    <dbReference type="EnsemblBacteria" id="ACU06582">
        <property type="protein sequence ID" value="ACU06582"/>
        <property type="gene ID" value="FIC_00107"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00107"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015077_1_0_10"/>
    <dbReference type="OMA" id="GGMEYAM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="400"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="673" mass="77776" checksum="764CF422996C4C18" modified="2009-09-22" version="1">MRKFWPAAKHRCRTKIQININPSMARLEGFFVHRIQRYDQNSYLSACKNLNKMNKGLLLMLSLVFGLFSAQQTAYYQQSAKYKMDIDVDAPNFTYKGNQTVSYTNNSPDELNVVYFHLYWNAFKPGSMMDQRVQNQGKNGDSRLQRDGISRLASIPEGEEGAQNIRWIKQNGKEVKFEVQETIMKVVLNSPLKPNSSTTFTMEWDAVIPHQIRRAGRNNREGIDMTMTQWYPKIAEYDYDGWATFDYIGREFHAPFADFDITIKIDKEYVIGAGGTLENPSEVKGYDANANIKSDNKNKATWRWTAKNLLDFAWAADRDYTVEEFTVLDGPKVYYVYQKSEKTQLWEESKQYVTKFFQLMNAAFGRYVYPSYSFIQGGDGGMEYGMCTMILGEGRSLEGLVGLMVHEGGHSYNQQILAYNESVRPWMDEGFTSYYDDYVMHQLFPPKEPVANPFVGSIRSYVNFTKTGKEEPAVWLADHHDNGSAYSIASYVKGDLFLVQLGYIIGEQKLSLVMKEFYNQWKLKHPTDRDFMHIAQRISGMDLKWFHHYWINTTKTIDYAVKDVQYGETSTTVTLENKGSVPMPVDFSILTTDKKVVNYQIPLNMTHTWKSSDIYGDFKTLNYWPWTQKEYTFTIPYSKSQISALGIDFSQRMADVNPEDNFVDVEAPKAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT0</accession>
    <name>C6WZT0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781762.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00140"/>
    <dbReference type="EnsemblBacteria" id="ACU06615">
        <property type="protein sequence ID" value="ACU06615"/>
        <property type="gene ID" value="FIC_00140"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00140"/>
    <dbReference type="eggNOG" id="ENOG50343UG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286926_0_0_10"/>
    <dbReference type="OMA" id="MEANILM"/>
    <dbReference type="OrthoDB" id="1231601at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973520" evidence="1">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="262" mass="29357" checksum="5AF14316A588ADAB" modified="2009-09-22" version="1">MTKLKLWMLATGIFALQSCSVNTETTYYKDAATSMEANILMDQSALGMLSMMGNQPGSLAQSKTFANLSTDWKSLYDIQKDGKVTLNGDSVKVLKKMFLKLNKAKGEVYGLSLKYDKLLPSEIASLFAQNKQLKNLPLQNVAKWDGKTLTIDTDKFNTTEFLSEMSKNSKDGPITQPKTKSDSVEVYGRQMAQGLLGMMKMFNMNFTSTMKFQKPITSITGQHDFVKQIDNKTIQINVRTKELLDDGKTLTHKDKNVIITTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW6</accession>
    <name>C6WZW6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="8" type="ordered locus">FIC_00176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781798.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00176"/>
    <dbReference type="EnsemblBacteria" id="ACU06651">
        <property type="protein sequence ID" value="ACU06651"/>
        <property type="gene ID" value="FIC_00176"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00176"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_0_1_10"/>
    <dbReference type="OMA" id="DWFKLHY"/>
    <dbReference type="OrthoDB" id="1575081at2"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="24020" checksum="6DFFCECE2462EB79" modified="2009-09-22" version="1">MKKIALITLIILVIDQVSKFYIKTTFHLGESVDVMPGFKLTFVENPGMAYGFHFGGLLGKYALVILRIFLIGGMVYLFRKWLKEGIHSNYLFIPMAMIFAGAIGNLIDGMFYGLIFDSGTVYDDSVGRWIDYGGISKVVPFGEGYSHFMKGCVVDMLHFPLVDWWVPESWPLIGGKHIEFFKYIFNVADSAITVGGLLLLIFRKKAFPEGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZZ4</accession>
    <name>C6WZZ4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781826.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00205"/>
    <dbReference type="EnsemblBacteria" id="ACU06679">
        <property type="protein sequence ID" value="ACU06679"/>
        <property type="gene ID" value="FIC_00205"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00205"/>
    <dbReference type="eggNOG" id="ENOG5031HSR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144077_1_2_10"/>
    <dbReference type="OMA" id="KHKIYLY"/>
    <dbReference type="OrthoDB" id="2077597at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032422">
        <property type="term" value="F:purine-rich negative regulatory element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021694">
        <property type="entry name" value="DUF3276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006628">
        <property type="entry name" value="PUR-bd_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11680">
        <property type="entry name" value="DUF3276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00712">
        <property type="entry name" value="PUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="111" mass="13440" checksum="2FF0618E79BE5283" modified="2009-09-22" version="1">MNDYKDRHENEIFTKVLKAGRRTYFFDVRETKAGDYYLTITESKKHFSESGEPSYEKHKIYLYKEDFKSFEEMFNESTDFIIKQKGEDVISERHDKDFKARSFTVDSDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X024</accession>
    <name>C6X024_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781856.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00235"/>
    <dbReference type="EnsemblBacteria" id="ACU06709">
        <property type="protein sequence ID" value="ACU06709"/>
        <property type="gene ID" value="FIC_00235"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00235"/>
    <dbReference type="eggNOG" id="ENOG5033200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383352_0_0_10"/>
    <dbReference type="OrthoDB" id="1947951at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="181" mass="21172" checksum="60B19E4E70C8DEF3" modified="2009-09-22" version="1">MRRSKTPLTPEVEFMTAKQKERIQLKIAKIRKELAADKKRWGGYYDDSRGLRYLPPELYLRIQDYSGALRYFNWFSKNFPDDSGYPVFLFEWVITLFKTGRLKEAKAKTLQTDLANSWIMPAFLQIRYSRPPAKIFSGWQTPEVAEEMSYSNDDAELADFAAWLRDFVSSAEFTGLRGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F8</accession>
    <name>C6X0F8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Capsular polysaccharide biosynthesis glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00377"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06844">
        <property type="protein sequence ID" value="ACU06844"/>
        <property type="gene ID" value="FIC_00377"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00377"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_8_0_10"/>
    <dbReference type="OMA" id="INGCNEI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="29"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="188"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="418" mass="46708" checksum="C0F29271DC2E0E3A" modified="2009-09-22" version="1">MKLFRIATVPISLNILLSGQLRFLNTHFDVTAVSGSGKDLDRVAEREGVNTHSVRIERKISILHDIVSLIRLYLLFRREKPTVIHSITPKAGLLSMIAGKWAGVPVRMHTFTGLIFPYRTGILRFVLVLMDRLLCSCATNIYPEGNGVKEDLLKYRITAKPLKVVADGNVNGVDTGFFCPRAVPQHERNKLRRQLGISPNDFVFIFVGRLVKDKGINELITAFEHLKKTYPEPGQNISIKGKTRIKLLLVGPMEPKESKLSRSTLHEIKTNPSIISVGYQDDVRSYYAASDALVFPSYREGFPNVVLQAGAMSLPAIVTDISGCNEIIKDGVNGYCIPSRNAEALGNVMLKLINDPKHFSEMKHVTRLIIRSKYQQATVWKALLSEYYSNLETLEESSVSPEVIGVQTQLISEPTADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G3</accession>
    <name>C6X0G3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00382"/>
    <dbReference type="EnsemblBacteria" id="ACU06849">
        <property type="protein sequence ID" value="ACU06849"/>
        <property type="gene ID" value="FIC_00382"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00382"/>
    <dbReference type="HOGENOM" id="CLU_3216567_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="44" mass="5057" checksum="D76EFEFE1F2E621D" modified="2009-09-22" version="1">MTVDIGKSDNKSIFAKKFIYEEISIVGSCTFSFIFMCTKIRSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0G9</accession>
    <name>C6X0G9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="5">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782002.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00388"/>
    <dbReference type="EnsemblBacteria" id="ACU06855">
        <property type="protein sequence ID" value="ACU06855"/>
        <property type="gene ID" value="FIC_00388"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00388"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031740_1_0_10"/>
    <dbReference type="OMA" id="APCVGCK"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02376">
        <property type="entry name" value="Cu_nitrite_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="343" mass="37028" checksum="53FAD3D2D4142FB8" modified="2009-09-22" version="1">MKQILTSFALALLTLQACKQNSTEGSASTENAMDIKVSGETETQTKLNPPMVPAPIGDRAAKKVIVHLESTEEEGVLADGVTYKFWTFNSTVPGSFIRVRVGDEVELHLKNASNSVMPHNIDLHAVNGPGGGAEATNVAPGKTAIFNFKALNPGLYVYHCAAAPVPLHIANGMYGLILVEPAGGLPKVDREYYIMQGEFYTKGKTDEKGLQEFDQDKGVDENPTYVVFNGKKNALMGDKMLEAKVGETVRIFVGNGGPNLASSFHVIGEIFDRVYMEGGSKINENVQTTLIPAGGAAIVEFKVEVPGEYVIVDHSIFRAFNKGAIGKLKVTGEENQKVFHKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0H3</accession>
    <name>C6X0H3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microcystin dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00392"/>
    <dbReference type="EnsemblBacteria" id="ACU06859">
        <property type="protein sequence ID" value="ACU06859"/>
        <property type="gene ID" value="FIC_00392"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00392"/>
    <dbReference type="eggNOG" id="COG4675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087872_0_0_10"/>
    <dbReference type="OMA" id="TYCICAS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011083">
        <property type="entry name" value="Phage_tail_collar_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07484">
        <property type="entry name" value="Collar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973303" evidence="1">
        <location>
            <begin position="38"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Collar" evidence="2">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="20102" checksum="30EB14E70BED8F4F" modified="2009-09-22" version="1">MRNCIVRNLSTSKLKTMKKFILSLTVLLSVTNLKAQAEPYLGQIAFVAFTFAPKGWAECNGQLLPISQNTALFSLLGTTYGGNGQTTFALPDMRGRVLIHNGQGNGLSNYELGQTGGTENHTLTIAEMPQHIHNVNAVSAEGNQNVPTGNLPANTKALDKEYADSTANTTMNLGMISPAGGSQPHENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N0</accession>
    <name>C6X0N0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type III effector HopPmaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00454"/>
    <dbReference type="EnsemblBacteria" id="ACU06916">
        <property type="protein sequence ID" value="ACU06916"/>
        <property type="gene ID" value="FIC_00454"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00454"/>
    <dbReference type="eggNOG" id="ENOG5032RP0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121622_1_1_10"/>
    <dbReference type="OMA" id="FGEHYRS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014984">
        <property type="entry name" value="HopJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038604">
        <property type="entry name" value="HopJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08888">
        <property type="entry name" value="HopJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="132" mass="15053" checksum="A0533CD80C1C5BE9" modified="2009-09-22" version="1">MTHENSVNNWNFEPRKINKNNMLLTQLQTSPETIAFQDVIAYIHQHYHFTPTKFTNGNAVNEAGQNNGSCKVFSFAKLKGLNEEETLALFGDFYRTDVLQNPEGADHQNIRNFMQSGWDGIAFEGEPLAEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N4</accession>
    <name>C6X0N4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PpiC-type peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00458"/>
    <dbReference type="EnsemblBacteria" id="ACU06920">
        <property type="protein sequence ID" value="ACU06920"/>
        <property type="gene ID" value="FIC_00458"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00458"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_13_0_10"/>
    <dbReference type="OMA" id="EGGDMGW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="189"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="292"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="467" mass="52882" checksum="53F0DB1E2320E3BA" modified="2009-09-22" version="1">MQNDNFADCKKQIMSKHIKFALLTSFILTFFGVQTHAQLKTGDLVDGIAVVVGNEIILESDIEDQANYAQQQGAAVADKCEFVESIINNKLLIYEAKRDTLIENRSESIKETANQKYAQILGQFPDEKTMLSTYKFRTSYEMKNAIEKIDTDNYYGQMKFGRITEKADVTPNEVTDFFNTYQFQLPEVKDEVSLSQITMYPKLTDAHKDEIIARLNKIKADIAAGESFESQARIYSEDPGSAATGGLYKNVARGKMVKPFEAAALNLQEGELSEPVESEFGYHLIQLVKKSGKMYDARHILLKAEPNADEIASARKELDSIRTLINEGKLTFKEAAFRFSDDKQTKFNAGILTSQDGSDRLEKLNLPPVVSYQIAGLNKGDITDVFQDTVQDRKVVTLIKVDDVIAAHRLDITTDYDRIKQMALNKKKNEMVEKWVKEKLPNIFISINDRYKACTFKTDWRKTTAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0R3</accession>
    <name>C6X0R3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782096.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00490"/>
    <dbReference type="EnsemblBacteria" id="ACU06949">
        <property type="protein sequence ID" value="ACU06949"/>
        <property type="gene ID" value="FIC_00490"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00490"/>
    <dbReference type="eggNOG" id="ENOG502Z7S0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039600_0_0_10"/>
    <dbReference type="OMA" id="DKMNVVY"/>
    <dbReference type="OrthoDB" id="326868at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019859">
        <property type="entry name" value="Motility-assoc_prot_GldM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022719">
        <property type="entry name" value="Motility-assoc_prot_GldM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022720">
        <property type="entry name" value="Motility-assoc_prot_GldM_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12080">
        <property type="entry name" value="GldM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12081">
        <property type="entry name" value="GldM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03517">
        <property type="entry name" value="GldM_gliding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="GldM_N" evidence="3">
        <location>
            <begin position="31"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="GldM_C" evidence="2">
        <location>
            <begin position="339"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="523" mass="55942" checksum="C205404A0EEF99E6" modified="2009-09-22" version="1">MAQGKQTPRQKMINLMYLVFIAMLAMQIDQEIIRSYNDTNQTLTDTRDLVEQKNDKIFEKTLEAKAANTPETYTKPLADYQGLKTRANDLVSFIEGLKTKLKQEAEYVDGIDVSENFAALNNTEPSSKMFFNGADENKPSKSSADLKAKMAALQTYIAQTFGGNSDMKHVVDRAKTTLTTELKKEQAIKNKNWLQYKFYGQPLIAALSNLEVIQSEARNLQSDALMTMLQEKVDADIKFDAYQAIVSAPTSVVLGEAVQAKVAIGNYSSNVPGLSMPGLSESNGQGIASLNTSSLGEKSFSGNISFTDVKGNVISLPYNHTYNVVAGSKEVAFESGALLSADKMQVLYRGLPNPISGSILGANNAQTTLSASGASVSKTGGGTWVVTPGGGSSTTLTISGKGPKGETISKAFTFRIKNVPPPVGEIQGKSVVSMPASSIPNQRVTADMPDFDFPVSFTVNSFMFKVPGRAAMQVSGNSLSSVAALTKNLRAGDIAYVFNINATATGLGGQALKQIPPVVINVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0W0</accession>
    <name>C6X0W0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01628"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08073">
        <property type="protein sequence ID" value="ACU08073"/>
        <property type="gene ID" value="FIC_01628"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01628"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015112_1_0_10"/>
    <dbReference type="OMA" id="GWEACGT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="561" mass="64847" checksum="5F6AD90A7F5FAF76" modified="2009-09-22" version="1">MRLNFLQSNYMDFDQFKMPFSINPDYSKKVAYFSMEFAIDQALKIYSGGLGFLAGSHMRSAYNLKQDLVGIGILWKFGYYDQARNHDQTLQPTWTKKMYTFLQDTGIKFQIEIHSAPVWVKVYYLDPEIFHTAPMFFLSTDVPENDHLSKTICHRLYDANESTKIAQYILLGKGGAKLLDEIKLERDVYHLNEAHGLPAAFYLLKKFGGDLAKVKEKLVFTTHTPEEAGNEKHDLYLCHNMSYFSGLSIDEVRNIEGEEDDRFNHSLCALKMARIANGVSQLHGEVSRKIWSKYEGICEIKAITNAQEFKYWADKPLYDAKDESDDMSFDFRKKHLKKRMFKIIADQTGNLFDPNIFTIVWARRFAGYKRADMLLHDKERFEKLLNNPKYPVQIIWAGKPYPMDYSAISTFNSLVEESKNHKNMAVLTGYELSLSKSLKQGSDLWLNNPRVPREASGTSGMTASMNGSVNLSTDDGWIPEFAKNGVNGYVVPQADYDNLSVYDQDNFDLENLYQALENEILPTYYDRPDEWRKIQQTAMDDVKTAFNSDRMADEYYKQIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0W3</accession>
    <name>C6X0W3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="8" type="ordered locus">FIC_01631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01631"/>
    <dbReference type="EnsemblBacteria" id="ACU08076">
        <property type="protein sequence ID" value="ACU08076"/>
        <property type="gene ID" value="FIC_01631"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01631"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_10"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="387" mass="41809" checksum="4A29BD74B3DD1E43" modified="2009-09-22" version="1">MKLPVTYYPSLIKIKMAKRDYYDILEVSKSASADEIKKAYRKMALKYHPDKNPGDKSAEEKFKEAAEAYEVLSDDNKKARYDQYGHAGMNGGGFGGGGGGFGGGMNMEDIFSQFGDIFGGQFGGGGGGGQRQQARGSNLRVRIKLNLEEMVNGTQKTIKVKKMKMAAGATAKTCTTCGGSGVQMKVMNTMFGQMQTQTTCGTCQGIGKIADKIPAGANAQGLVKEDEEVTINIPAGAREGIQLNVRGKGNDAPFGGNPGDLLVVVEEETDSKIKREGDNLHQELYISFAEAALGTQKEIPTVGGKVKIKVDPGTQSGKILRLSGKGLPSIDSYGKGDMFVHINVWTPQHLTPEQRAFFEKQIANNEMMAEPSGKEKTFFDKVRDLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0W4</accession>
    <name>C6X0W4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="6" type="ordered locus">FIC_01632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01632"/>
    <dbReference type="EnsemblBacteria" id="ACU08077">
        <property type="protein sequence ID" value="ACU08077"/>
        <property type="gene ID" value="FIC_01632"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01632"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_2_10"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="199" mass="22991" checksum="B1F8BD73BA7B29B4" modified="2009-09-22" version="1">MSVNRIWQNLCEPRLINSIIMSENKEILDDDLNPQEEITQNIEEETTENVTTPPSSDDLLADEKERYIRLFAEFENYKKRTSKEKMEFFQYANQDMMISMLGVLDDFERALKEIAKNGNEADLQGVELIYQKLKSKLTEKGLKPIEVNVGDTFNVDFHEAITQIPAPTEELKGKIVDVVETGYQLHERVIRFSKVVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Y7</accession>
    <name>C6X0Y7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806385.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01656"/>
    <dbReference type="EnsemblBacteria" id="ACU08100">
        <property type="protein sequence ID" value="ACU08100"/>
        <property type="gene ID" value="FIC_01656"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01656"/>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_1_0_10"/>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="OrthoDB" id="1777855at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="22843" checksum="22EC24C62AC3DB6C" modified="2009-09-22" version="1">MKFEYNTLKTSVSEVLIKEKGSKFIGFAFPLGGEADLKKNLDKIRAEHPKATHHCYAFRLGINGENYRANDDGEPSGSAGLPIYNQLLAHEITNVLVIIVRYYGGTKLGVAGLVKAYKECAKQTIESAEIVTKELETTVVIHFSFEKQNQIFTLLNKFDARIEEFMSEENCSISARIKTSIKENISEQMFEMQNISFEFLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X124</accession>
    <name>C6X124_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="9">OPRT</shortName>
            <shortName evidence="9">OPRTase</shortName>
            <ecNumber evidence="9">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrE</name>
        <name evidence="11" type="ordered locus">FIC_01694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806422.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01694"/>
    <dbReference type="EnsemblBacteria" id="ACU08137">
        <property type="protein sequence ID" value="ACU08137"/>
        <property type="gene ID" value="FIC_01694"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01694"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049275_1_0_10"/>
    <dbReference type="OMA" id="DHLGQQY"/>
    <dbReference type="OrthoDB" id="1150446at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OMPdecase" evidence="10">
        <location>
            <begin position="235"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="9">
        <location>
            <begin position="117"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="453" mass="50297" checksum="7CB955AE7531636F" modified="2009-09-22" version="1">MESKKKFFLECYQLGIIKFGRFTLKSGIESPFYVDLRPLASDPKILKRLANYMLDMLPLDNFDLICGVPYAALPMATAMSLESYLPLIIKRKEAKEHGTKKLIEGIYRKGQNCLLVEDVITSGKSLLETIPEIENEGITVSDVVVVLDRQQGGKELLEGKGYRVHTLFTISEVCKMLQEEGLLSDDEVLRIGDFLQGNQVVFDEGKRLSYEQKLQSVEHSVAKKLLETAIAKKSNLIASADVLTTQELLDLADKIGPHIVALKTHIDIITDFDPDNTILPLKDLALKHNFLLMEDRKFGDIGNTQELQFSYGMYKISNWADFVTSHVIGGYHALDCFLNVGVVAILGMSSKGTLTDKNYQEEALKVAQAHPNVIGGVSQKAIPDELLLFTPGISLGEASDGKGQQYHSPKHAFSNLKSDFIIVGRGIYKADDAESAALTYKIEGWNAYEQTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X184</accession>
    <name>C6X184_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01754"/>
    <dbReference type="EnsemblBacteria" id="ACU08197">
        <property type="protein sequence ID" value="ACU08197"/>
        <property type="gene ID" value="FIC_01754"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01754"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_1_10"/>
    <dbReference type="OMA" id="AMIPAFF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="15"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="313" mass="35142" checksum="5A18A0C62CA4265C" modified="2009-09-22" version="1">MYFCRVKFSNDYRLILAVLTVAIVWGTTFLGIRIAVESIPPWFVAGIRQFIAAALLLVILLFSKELKWIGWKNLGIQIIFSILMLIIANGMMTVAEKHITSSLASLISAASPLLVFLGSIFFRLQKFTVRALVGIIIGFIGILLIFKDGLEDLLNPDYRMGVLFSFIAISGWALGSIFTKKLHLQKQNISLNLFYQFAFSAVVQITFGFILSDKIEVETWTFRSMFATVYLAVFGSVAAYFAFHYALKKISPTQISLLSYINTIIAIFLGWLVLDEEISAAFITATVLIICGVFITNYQKGMFSRSRPSREID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X191</accession>
    <name>C6X191_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PspC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806489.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01761"/>
    <dbReference type="EnsemblBacteria" id="ACU08204">
        <property type="protein sequence ID" value="ACU08204"/>
        <property type="gene ID" value="FIC_01761"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01761"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017085_0_0_10"/>
    <dbReference type="OMA" id="MGQPEDY"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="567" mass="63499" checksum="ED81C66D0081CC36" modified="2009-09-22" version="1">MNKTLSIGLAGFSFTIEEHAYIKLSDYLAALRSSLEASEADEVMHDIEIRMVEIFKDTLGKREVINDSDVERVIAQIGRPEQIEEQEEAYFSEKAARKDHKTSANFTGQKQLFRDPEKQKIAGVCAGLAHYVGMDVSAMRAIWLGIAILGVFTAAISTSLIVLIYIILWIVLPRAETATDFLKMKGKPMNFDNLKSESNKLVQFANESTQRVGEIYTENKPYISNAGSGIWNVIRYVLGGIFGLMALGSIIGAFFIFGLFGGSDFAPMQEFNFLFDDDGMSNVLYAMMLIGVLIPAILFSLLSIKLISPKTQLRNVGYVLGALFLILIAFGTYFGINMAKKDMIYKGHKEDVENVAINTTSDSLYVDVKQITIPQNFTAYDDDIFSDKKMVYEEDYPYVEVTRKADITAPYLIIKKDGKGYNLPVQLNVPVEIQGNRVLLPNFVKYPYQDRFRDYNVNYELVVPMTTRIFKVKDNALNLDGDLNGDGTDDDDDDSNGIIFENDKIKINGSTIQYSSDEADSVIINGTKMPKAAADKIIDSMKLNLRHMENVNISVKDGKKEISIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1A7</accession>
    <name>C6X1A7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806505.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01777"/>
    <dbReference type="EnsemblBacteria" id="ACU08220">
        <property type="protein sequence ID" value="ACU08220"/>
        <property type="gene ID" value="FIC_01777"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01777"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786982_0_0_10"/>
    <dbReference type="OMA" id="RTHWIAG"/>
    <dbReference type="OrthoDB" id="1180520at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="352" mass="39359" checksum="E7AE686557FD803C" modified="2009-09-22" version="1">MLSISLHFLVIAFIILLCVVSLLIVVVLLYGLYQYRKQGKIDLWQEIIDEEISHAIVNEDEASARPKLDALSGKPAFRMIFLEKLVSAESKFSGMAGGVIRSLFGRYGLEKEALNKLNQKRPFLIAGGIQELTSMQVEKALPAISGYLQHLSPQVYQEAQYSVVSFKGFEGLAFLDDAMGILSEWQQLRLLNSIPSVPADAGERISFWLQSGNSSVIIFTLRLITKYQLLSLYDEVLLLLNHHELSVRLQAVQSLQSLENSGTLTDLQSVYTSQPVDVQIEILKAIKKMGDLRAVIFFREKLYSNAPASVRIHAAEGLFELGMASELKELASRTDTETELIMIIKHALQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B0</accession>
    <name>C6X1B0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="2">2.4.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806508.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01780"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08223">
        <property type="protein sequence ID" value="ACU08223"/>
        <property type="gene ID" value="FIC_01780"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01780"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032719_1_0_10"/>
    <dbReference type="OMA" id="VFMLAEW"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="23"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="450" mass="51897" checksum="AC3E89B2CAA1D322" modified="2009-09-22" version="1">MKKILFAAIVGFGLVSCTTQKNTTMTELPSEWKRTTNIYEVNIRQYTKEGTFRAFEKEMPRLKEMGVKTLWFMPITPIAQKNKKGPLGSQYAAQDYTAINPEFGTMADFKHMVDEAHKMGFKVIIDWVANHTGWDHVWTKTNPEFYLKDPNTNDFQKASGMDDIIELDYSNPQMRLAMIEAMKFWVRETNIDGFRCDLAAWVEVDFWQQARPEVEKVKPLFWLGEFDELDNPDYGKVFDASYIWNWMHKTKDYNEGKASYGDLKTLLSRYSAIGDSSMRAWFTSNHDENTWNGTEYEKYGLLAKPLAVFSVTWNGVPLIYNGQELPLKSKRLEFFTKDPIPWTGTYELHDFYKTLLNLKSNNPALRGGDPAVTTYLLKTSADDKIMAYLRKNGKDEVLTVLNMSQEAVTFRLDDAMINGVYTNVFENSARDFSQDKGFVLKAGDYAVFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E0</accession>
    <name>C6X1E0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ordered locus">FIC_01810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806538.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01810"/>
    <dbReference type="EnsemblBacteria" id="ACU08253">
        <property type="protein sequence ID" value="ACU08253"/>
        <property type="gene ID" value="FIC_01810"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01810"/>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_10"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="1184806at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="54"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="288" mass="32947" checksum="DC64F3CF4E37B45A" modified="2009-09-22" version="1">MNDNLIVSPIQKPKWIRVKLPTGKNYRELRTLVDKYKLNTICQSGSCPNMGECWGEGTATFMILGNICTRSCGFCGVKTGKPLDVNWDEPEKVARSIKLMKIKHAVLTSVDRDDLKDMGSIIWAETVKAVRRISPGTTMETLIPDFQGITKHIDRILEVRPEVISHNMETVQRLTREVRIQAKYERSLEVLRYMKEAGQNRTKTGLMLGLGETKDEVLQTIEDIRGANVDVITIGQYLQPTQKHLPVRRFVDPEEFEEFRLFAVDLGFRHVESSPLVRSSYHAEKHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E8</accession>
    <name>C6X1E8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806546.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01818"/>
    <dbReference type="EnsemblBacteria" id="ACU08261">
        <property type="protein sequence ID" value="ACU08261"/>
        <property type="gene ID" value="FIC_01818"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01818"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_10"/>
    <dbReference type="OMA" id="GIMNITF"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="311"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="409" mass="44825" checksum="73C8482D52E9C2A0" modified="2009-09-22" version="1">MFDLDRWREIFESIRSNILRTVLSGFTVALGLYIFIVLFGIGSGLKNAFTEGFTRDAANLISIFSGKTSLAYGGLQSDRQIVLKNEDFDNVVDSDPEKVESATPRYSTNMTVKYGKESGSYQISGANPNEQIIENRVLTEGRYLNNRDMSEKHNVAVIGRMVQRDLIKNGSPIGKDLAINGTFFKVVGVFSDDGGDWDERMITVPITTLQQLKKGSDTVSTIFVTYDQKLSPAQAIEYGEQLQKQLKAKNKVSPDDEQGIIVRNNAKNMGDTIQFLFIITLIVGFIGMGTLLAGIIGISNIMVYIVKERTQEIGVRKAIGAKPGSIVGLIMQESVVITVISGVIGVALGILSLELIGDNLEKYFIKDPSVGWGLIFVAFISLVLSGLIAGFVPAYRASRIKPIEALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P3</accession>
    <name>C6X1P3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lpxD</name>
        <name evidence="7" type="ordered locus">FIC_01914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01914"/>
    <dbReference type="EnsemblBacteria" id="ACU08356">
        <property type="protein sequence ID" value="ACU08356"/>
        <property type="gene ID" value="FIC_01914"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01914"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049865_0_0_10"/>
    <dbReference type="OMA" id="QIQIAHN"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="6">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="362" mass="39091" checksum="FC66E0C0DE207BD4" modified="2009-09-22" version="1">MHKRQKTFAIFGIFLSLQDMEFTASQIAAFIDGKIIGDENATITGVSPIESCEPGHLSFVAQERFAEYIGKAKCSVLIVSEKLLTAETYPTTVIAVEDAYLSFQVLMNLYKEMQGRKTGIEQGAVFHESATVGEDVYVGAFTCVSEKVKIGDGSQIYPQVYIGKNVKIGKNCIIYSGVRIYDYCVVGDDCVIHSNTVIGSDGFGFQPTKDGYQKIPQLGNVILEDHVEIGSNCSIDRGTIGSTVIGRGTKIDNLIQIAHNVKIGQNNVIAAQAGIAGSTTIGDWNQIGGQVGIVGHINIGNQVKIQAQSGVNSGAKDGDVLYGSPAINAGEYRRNYVHFRNFTEIVKRITAIENTSKNNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1S9</accession>
    <name>C6X1S9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08392">
        <property type="protein sequence ID" value="ACU08392"/>
        <property type="gene ID" value="FIC_01950"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01950"/>
    <dbReference type="HOGENOM" id="CLU_3025625_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="55" mass="6072" checksum="2F425B1BC0D89DD9" modified="2009-09-22" version="1">MMAQSYKPGGVFGTESAVTGPLMVYRDRDLSTIKSSSKKFTSLELFDSSGRLVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T1</accession>
    <name>C6X1T1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806679.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01952"/>
    <dbReference type="EnsemblBacteria" id="ACU08394">
        <property type="protein sequence ID" value="ACU08394"/>
        <property type="gene ID" value="FIC_01952"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01952"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283974_0_0_10"/>
    <dbReference type="OrthoDB" id="253033at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1095" mass="117838" checksum="6493722ED18864AB" modified="2009-09-22" version="1">MMKTNLLCLINSYRNSPVKLLLLGFILSYVMYNGQTTIVSYQFNNNLNSDTTPVPPLNTSLTYNYANGNPRTPGYDNSWLRAVGGGDYLELSIDASAYQNMVVSFDGRFSAFFGTGSWTVYANTGAGNSFQNLGDLQLLSLFGSTATDSFSVALPAGANNKTGLKIRIEVYLGLDLGDNLRIDNLKLSTGTPKIQVYSATPPANTHIPHLSPASAALTTDFGTRQTSLGPQTKGYRVRNLQGTSGSQLTVNSITVSGANPGDFTVSPSSLSPVGVATTPSGTFVLFYISFKPLADGIRTAEINLYSNAAPSPYKFTVMGVGASCSLESTAYVTNNFALTDQTLESSCSAADLVAGSSSPSGSNSLTTQLYPGAQNLYSSATSSLMFRGNTEKTIEFCGLNGVNVAQKKDVAIAFNVAAFTTTDKPQHWWNNPTVNDDTENGLNINSTIKVSVLKPDNTWSDEIVLRGSESSGLYFRNHFLSGNQAVATMGLGTVISNTNSTKYNSVVLNIPASAGVTNLKFRIKGKTENNNKLWLIDDVRILSSNAVYKVWNTVAGNTNWRSSSGVVIPAPTLDEKVFIDSDYTGVRPSIDACECEINPGKSLTVEADRHLQLRGALINNGTVTVNSDGSLIQLEDEAVNTGNILLKRNLSFRNNDRKEYNYLISPVEGANLKTDIYKTGTMAAVAAPFALYYNEATSFFNNSTGAYIEGRSLAVKEPPLSSGALPTAFFTGKPFNGVLEYALAYSGAVSGYNLVGNPYPSNIDLNMLYEDNNTEIESTFRFWDNTVNSFYEQQGSTYDGSAYAIFNAATGTGGEGLPAPGYGQMATAPGASKVPNNIVKTGQGFMVRSLGPGKVLKFANALRLADNAGSVFYGKQNTDDRFWLSMAAPSGITSNMALVYFSGGNNLFAVDDSEAFGGSDDVFSIVENEKLSIDGRSAFVDTDAVTVETRHFSAGSYTFSLNMKTGVFANGQAVYLKDKHTGIITNLNEGNYTFSADAGESTGRFEIIYKPTTILAVDFDTKDELTVYRDGNRFVVKAQSKKITQLELFDTAGRLIYRAQPNALEAFISAEDLRNGMYITRIDQSGLITAKKIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T2</accession>
    <name>C6X1T2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806680.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01953"/>
    <dbReference type="EnsemblBacteria" id="ACU08395">
        <property type="protein sequence ID" value="ACU08395"/>
        <property type="gene ID" value="FIC_01953"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01953"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_292007_0_0_10"/>
    <dbReference type="OrthoDB" id="1197565at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1044" mass="113061" checksum="77D88168644BA9A5" modified="2009-09-22" version="1">MKKKSIYSIQRATFQKAIFLLLFLPALMMSQSTLVRWFNSNLQPTVMQNSITAQPVSGVVHQEYWSQEAFYITHNTISSSAAPDPLKFIQFTVTASAGYKINLTNFSFSARKHGGDDVQKFTVKYSRKADFSDAQTLLAETVSNLAYQAFSPNFPANTVVGSGETMYVRIFVYNTYNNFHLLHNEAGNLGPALSGNVTADIATVPLAVDDRSGTTKNKEVTIDVLANDVYSIGHPVTAVSFVAAPQNGVAVVNSDKKIVYTPAMGFTGYDLFYYTITNSAGVSNTAKVELQVIDGSATVTERWNRSDFMPVNYISGITGSALQPHGGVTISNFDSYWVNNKKHQAFRIEQMPTLTDLNGALVPTKFIQFSVTSTLQDELLLVKHFNMRYNAEGPGNFTIRYSKNADFSSGVKTLVDHYRYSHQDNGWSDLNAEFTEDAFLYPAETLYVRIYFYNTGYSSAKFYINYGYPDTPNVLAGPTLTGIKSEIYAGSCTSTAVWGGSSWSETPSIRKKARIDADYNSAVHGGFEACSLEVTNGLLTISEGTAVKLTNQLDVRPSGSVVVANGANLIQVNDSAAPNSGNIKVLTNIKISEGRAQYNYLGSPVTFAPGHSLKTIYPGISFVTYHNEANNLFYSSSGANIPGRGLAVKEPTVAAIPATATTVTATYVGVPQNGVINYALANSNTSTSTHLGFNLLGNPYASNLDLKALYKLNKDKVAQDAPVPFSSSFYLWDNTVNTIYVQQGSSYKGQAYAVYNALAGTNGTGTPAAGSGSKPQSSKIPSNVMKVGQGFMVKALLKNSTFVFNNSVRTAESCPIEFLGKTASQTEDDRYWLTLTTPTDMATSLAVVYFEEGNAALGAEDSESGGSDDELFSIVNGKNVSINGKGSFSNTDAVELGTRHYSAGVHTISILKSEGVFANGQHIYLKDRQTGAITNLSQNSYSFAANAGDSTGRFEIIYKPEVVLATDNAVKQEVAVYKDGNNFVVRSKHDRISSLQLYDAVGRLVYTAKPNAGTAEISKESLAAGVYILRIMHADQVTVKKIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1T7</accession>
    <name>C6X1T7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806685.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08400">
        <property type="protein sequence ID" value="ACU08400"/>
        <property type="gene ID" value="FIC_01958"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01958"/>
    <dbReference type="eggNOG" id="ENOG5032X6Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2181950_0_0_10"/>
    <dbReference type="OMA" id="IYFLAGT"/>
    <dbReference type="OrthoDB" id="2019738at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="112" mass="12415" checksum="77F45080F478DA63" modified="2009-09-22" version="1">MQRTLIYFLAGTAISFLLNYFLLGSAGWALDLYYAVAFGAAWAIAYFLDDEKFSLIQKLGISFISMVALVALGTLIFSLELAVPSVIKFSMVFVAYYVLASFRGTKSLRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U7</accession>
    <name>C6X1U7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08410">
        <property type="protein sequence ID" value="ACU08410"/>
        <property type="gene ID" value="FIC_01968"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01968"/>
    <dbReference type="HOGENOM" id="CLU_3135933_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="49" mass="6054" checksum="94A0D01449D8DB02" modified="2009-09-22" version="1">MDGIESKKRGKQKKLLHIERKNNSIFAQLGIYRIFRWVKVWLKYNLKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1V3</accession>
    <name>C6X1V3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="2">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="2">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806701.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01974"/>
    <dbReference type="EnsemblBacteria" id="ACU08416">
        <property type="protein sequence ID" value="ACU08416"/>
        <property type="gene ID" value="FIC_01974"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01974"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_10"/>
    <dbReference type="OMA" id="CPKGISL"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="255" mass="27818" checksum="EF9BF73043FE1A38" modified="2009-09-22" version="1">MSAKKGLNLTLKIWRQKNNKSKGQFETYKISDVSTDSSFLEMLDMLNENLINDGIEPIAFDHDCREGICGMCSLYINGRAHGPDTGITTCQLHMRMFKDGETIHIEPWRSAAFPVIKDLVVDRSAFERIMAAGGFISVNTSGNTLDANAILVPKEDADKAMDAAACISCGACVATCKNGSAMLFVGAKVSQYALLPQGRVEAKRRVLNMVKAMDEEGFGNCSNIGACEVECPKGISLENIARMNREFMSANLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z6</accession>
    <name>C6X1Z6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="8" type="ordered locus">FIC_02017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806743.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02017"/>
    <dbReference type="EnsemblBacteria" id="ACU08459">
        <property type="protein sequence ID" value="ACU08459"/>
        <property type="gene ID" value="FIC_02017"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02017"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_10"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="92" mass="10164" checksum="291C09E6B973A81D" modified="2009-09-22" version="1">MARSLKKGPFIHHTLDKKVQTNIESGKKTVIKTWSRASMISPDFVGQTIAVHNGKSFIPVYVTENMVGHKLGEFSPTRSFRGHGGNKNKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X218</accession>
    <name>C6X218_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806765.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08481">
        <property type="protein sequence ID" value="ACU08481"/>
        <property type="gene ID" value="FIC_02039"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02039"/>
    <dbReference type="eggNOG" id="ENOG50334XX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169686_1_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="74" mass="7447" checksum="B147D8B44E9455AE" modified="2009-09-22" version="1">MKKSFFVAGIAALALVACKKTETVETANATDSLEVAADSTINVIDSTETAAIDSVQATAEAATDTIKAGVDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X226</accession>
    <name>C6X226_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_02047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806773.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02047"/>
    <dbReference type="EnsemblBacteria" id="ACU08489">
        <property type="protein sequence ID" value="ACU08489"/>
        <property type="gene ID" value="FIC_02047"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02047"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_10"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="9">
        <location>
            <begin position="55"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="410" mass="45676" checksum="857B31EE83033DE2" modified="2009-09-22" version="1">MFLQKSKLTGNKTIEISGSKSISNRLLILQHLVKNIKIINLSDSQDTQLLQEALNSDKDLIDVHHAGTAMRFLTSYFAIQDGKTVTLTGSARMKQRPIKNLVDALRDLGADIQYLENEGFPPLKIVGKNLEKNTVTISADISSQFITSLMLVGAKLENGLQINLSGKITSKPYLEMTLKILRTLEIPNQWTGNTISISPAIRSQKSSQPVPFVVESDWSSASYFYSLAAISRETVNLRCFKPYSLQGDSVLKEIYWKFFGVNTISEGAESRISLMPEPFFSLPESISLDMNDCPDIAQTLCVTATALQIPFGITGLATLKVKETDRLLALKNELFKIGCIVEITDDSISSVKFFDPNENICIATYNDHRMAMSFAPYCLVKSLTIENAEVVEKSYPKFWDDLNEITVITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X228</accession>
    <name>C6X228_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02049"/>
    <dbReference type="EnsemblBacteria" id="ACU08491">
        <property type="protein sequence ID" value="ACU08491"/>
        <property type="gene ID" value="FIC_02049"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02049"/>
    <dbReference type="eggNOG" id="ENOG50333JQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101328_0_0_10"/>
    <dbReference type="OMA" id="NTRDENA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="27161" checksum="043F3163F07797F5" modified="2009-09-22" version="1">MYICVDSKLTNYRLMKTFFSVMALSLAGLTIHAQQISLGEISRMAKFSKMIDEVNNGKQKIKYSDIEGRPYYKPDFAVARVGDTSGSVPVRYNSFLDTVEILAGMEVYEIPREESYPKFTFEKTGEKLVLVNTRDENAGYFFELEGGKNRLLKKVVTKFHDAIPPPNTMIPGTPARFEMLKPMYFIKSEAGLVKIPKNAKDLAESFPEKKSELNAFIKTNKIKLNQEADLVKLTKFLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X254</accession>
    <name>C6X254_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806801.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02080"/>
    <dbReference type="EnsemblBacteria" id="ACU08517">
        <property type="protein sequence ID" value="ACU08517"/>
        <property type="gene ID" value="FIC_02080"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02080"/>
    <dbReference type="eggNOG" id="COG3685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102561_2_0_10"/>
    <dbReference type="OMA" id="FEMIGKP"/>
    <dbReference type="OrthoDB" id="1739824at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="1">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="20601" checksum="1479E1C6F4839AA2" modified="2009-09-22" version="1">MDTKKTNSKAAEQPGDANSLRELFTDGLKDIYYAENALLKALPEMYEKAVNTKLKTAIKDHITQTEMQVIRLEEAFSHMGMKAEGKKCLAIEGIIAEGRQCVSSTTEGPVRDAAIIGSSQKVEHYEIASYGTLAAHAKVLNEREVLDLLLRTLGEEKKSDCLLTIIADTELNSQAAGGMHQSKDFKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X297</accession>
    <name>C6X297_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02123"/>
    <dbReference type="EnsemblBacteria" id="ACU08560">
        <property type="protein sequence ID" value="ACU08560"/>
        <property type="gene ID" value="FIC_02123"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02123"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_2_2_10"/>
    <dbReference type="OMA" id="TWGFAYG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="485" mass="52286" checksum="EF1FA8E361B249B0" modified="2009-09-22" version="1">MLTNMSTTTTKTNWAQFIPLVTVFFFWGFVAASNDILIPVFKKAFNLSQSQSQLVSVAFYIAYTVGSLIYLFISKALKNDLVNRIGYKNGLIYGLLISVVGTLFFIPAANNSSFILMITGLFVIGLGFSLLQIVANPLAIALGPKETGSQRLTLAGGINNFGTTVGPLIVSFAIFGAASAENTEASIESVKTPYLALGVAFILVAILIKFSKLPKITSVVSEDTDDAPDGHHRTSAFQYPQLWLGMIAIFVYVGVEVATASNLPAYMENDLGFETKDIAPYISLYWASLMIGRWGGAVDAFDVKAGTKKILRFLAPYLAFALFLGVNAIARHDLSPFYVYGIIILVMIAADIMSKGNPARMLLIFSSLGIASLLVGMATTGMVSVYAFTSVGLFCSTLWPCIFALAINGLGKHTNQGSSYLIMMIMGGGIVSWLQGVLADYTNIHFSYVIGIACFAYLAFYAIRVTGILKAQGINLDRLKTEGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A7</accession>
    <name>C6X2A7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02134"/>
    <dbReference type="EnsemblBacteria" id="ACU08570">
        <property type="protein sequence ID" value="ACU08570"/>
        <property type="gene ID" value="FIC_02134"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02134"/>
    <dbReference type="eggNOG" id="ENOG50311VN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1486966_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="181" mass="20735" checksum="BB32F35D8348E0B4" modified="2009-09-22" version="1">MRYFLSTFEKHPPQMKSLFFVLIATIICSCTPNENPAPRAISAEAQRIDSINAERRKWNDSIAIKNQQNIFKDESGKHRLKFSTDGVAFSGWLTFIKSDRDFYNVSGLAKSGSNTLNIRGTIKKVSEKHLNFDGEIMQNINGNTFKRTKKSTFLDGGKGNFWRLQNKINSDGFVDYIDIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B4</accession>
    <name>C6X2B4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
            <ecNumber evidence="2">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.20.4.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806861.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02141"/>
    <dbReference type="EnsemblBacteria" id="ACU08577">
        <property type="protein sequence ID" value="ACU08577"/>
        <property type="gene ID" value="FIC_02141"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02141"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093779_0_0_10"/>
    <dbReference type="OMA" id="VTCYSGG"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="23119" checksum="AAC49F8E01ECF1F7" modified="2009-09-22" version="1">MYAKLLQTISEFSESQISDERKKTLQPFIEFISQKQTEGEDVRLNFICTHNSRRSHLAQVWAQAMAYHFRLKNVCCYSGGTEATALYPQVAETLRKQGFEIDKLSETQNPVYAVKFSVNAHPVIGFSKKYGYHFNPTSGFCAVMTCSSADHDCPFIPGAEKRIAIPFEDPKIFDGTNQMDNKYAEKSIEIGREMWFVFKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D3</accession>
    <name>C6X2D3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02160"/>
    <dbReference type="EnsemblBacteria" id="ACU08596">
        <property type="protein sequence ID" value="ACU08596"/>
        <property type="gene ID" value="FIC_02160"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02160"/>
    <dbReference type="eggNOG" id="ENOG50338AH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095611_1_0_10"/>
    <dbReference type="OMA" id="ANFIKYN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="192" mass="21535" checksum="B92A886D4D8A45CB" modified="2009-09-22" version="1">MEKYFYFLFFFMSVLACGQSKYTAAQVEQSTDPKVIANFIKYNPNHPKTPEFKRKLFAAINNNKPAAAKATVAKPVVKPISTEKLKTAIKKDVARDGSNDKNKRTAELLTHLFNTDPSSKNAYVQIVNKSKCNLIVKISGRKFYNLDVPARNQNYILVDKGNYTLTTSVCDAKYSSAKNINKDIVVTLNAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2D4</accession>
    <name>C6X2D4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08597">
        <property type="protein sequence ID" value="ACU08597"/>
        <property type="gene ID" value="FIC_02161"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02161"/>
    <dbReference type="HOGENOM" id="CLU_3403662_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="30" mass="3655" checksum="1C15A3E53FA48CFE" modified="2009-09-22" version="1">MVFRSLNFTYNGEMFFLVYVEFIIFATLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2G0</accession>
    <name>C6X2G0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maebl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806907.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08623">
        <property type="protein sequence ID" value="ACU08623"/>
        <property type="gene ID" value="FIC_02187"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02187"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034061_0_0_10"/>
    <dbReference type="OMA" id="IDADNTQ"/>
    <dbReference type="OrthoDB" id="990092at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="1">
        <location>
            <begin position="168"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="246" mass="27654" checksum="A0B20B65628AB344" modified="2009-09-22" version="1">MTDDKLAVLIDADNVPYANVTQMLEEISRYGTPTIKRIYADWTKPTVSGWKGVLLENAITPIQQYSYTTGKNSSDSALIIDAMDILYSEKVTGFCIVSSDSDFTRLATRLREAGMTVIGFGEKKTPKPFISACDKFIYLEILKNTATETAVEKKTAKPKRKAEPLSKVDARTVKLIVESVNDLADESGWTFLGNLGNFIIKKKPDFDPRNFGFPKLLPLIRNTGKFEIDERETGLNNIRHIYIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2I0</accession>
    <name>C6X2I0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806927.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02208"/>
    <dbReference type="EnsemblBacteria" id="ACU08643">
        <property type="protein sequence ID" value="ACU08643"/>
        <property type="gene ID" value="FIC_02208"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02208"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056519_2_0_10"/>
    <dbReference type="OMA" id="MGYDTRP"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="42"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="288" mass="33081" checksum="516E44C2F5F44CDF" modified="2009-09-22" version="1">MKLYPIQCGKFKLDGGAMFGVVPKSLWERTNPADEKNLIELGTRSLLVEDGKKLILIDCGLGNKQDEKFFGHYSLWGDDNLDKSLKKYGFVREDITDVFLTHLHFDHCGGAIEWNSDRTGYQPAFKNAQFWTNEEHWKWATEPNPREKASFLKENILPMQESGQLNFLPTPVTGNYGFAPDLKMDVIFVDGHTEKQMLPVIRYQDKTVVFAADLIPTAGHIPQVYVMGYDTRPLLTMEEKGKFLKQCIDNEYLLFFEHDAHHELASLKMTEKGVRLDETFSLNDVFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S6</accession>
    <name>C6X2S6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807023.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08739">
        <property type="protein sequence ID" value="ACU08739"/>
        <property type="gene ID" value="FIC_02306"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02306"/>
    <dbReference type="HOGENOM" id="CLU_2478801_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="87" mass="10500" checksum="3A7461E23C6AF2C0" modified="2009-09-22" version="1">MMILNLFSKKKKALFFEEADWRHDEHQRNYCLRLPLKKTKITPQTKIYLYKQQGERYIFMSEGHEIVEGNEVVYFSQAPFSGKVRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V9</accession>
    <name>C6X2V9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02339"/>
    <dbReference type="EnsemblBacteria" id="ACU08772">
        <property type="protein sequence ID" value="ACU08772"/>
        <property type="gene ID" value="FIC_02339"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02339"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_2_10"/>
    <dbReference type="OMA" id="GKNCNIA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="20727" checksum="17626B0D5DCE665D" modified="2009-09-22" version="1">MAMAQHSIIQKDFFRESGKIFSSAEIWAKCINPNLHFIYILRKCQSHPKKSVLGMFWRLVLRRHQIKYGFQIYPETQIGEGFYLGHWGAVVINPKTKIGKNCNIAQGVTIAQANRGKNEGVPTIGNEVWIGPNAVLVGNITIGNNVLIAPNAYVNFDVPANSVVIGNPATYTENLNATEGYINNKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2W0</accession>
    <name>C6X2W0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 6">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807057.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02340"/>
    <dbReference type="EnsemblBacteria" id="ACU08773">
        <property type="protein sequence ID" value="ACU08773"/>
        <property type="gene ID" value="FIC_02340"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02340"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_3_1_10"/>
    <dbReference type="OMA" id="GWVFDIH"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="226" mass="26120" checksum="237FD3411837CA9B" modified="2009-09-22" version="1">MKKSYEVIFENNRKWVESKLAEDKDFFKTLSGSQNPDYLYIGCSDSRVSAEEMMGLKPGEVFVSRNVGNLVNNLDLNVTSAIQYAVEHLKVKHIIVCGHYGCGGVRAAMTPEDLGILNPWLRNIRDVYRLHQQELDAITDEQKRYDRLVELNVLEQCINVIKMAVVQEEYLVDEYPIVHGWVFDLRTGKIIDLEIDFESTLKDIQKIYNLTNSDWVMSKKNNKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X5</accession>
    <name>C6X2X5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807072.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08788">
        <property type="protein sequence ID" value="ACU08788"/>
        <property type="gene ID" value="FIC_02355"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02355"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133067_1_3_10"/>
    <dbReference type="OMA" id="FEIAWAI"/>
    <dbReference type="OrthoDB" id="1990300at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="112" mass="12179" checksum="53EF6BBC62287422" modified="2009-09-22" version="1">MNWIILIIAGLFETGFATCLGKAQETTGRESYFWWAGFAASLFISMFLMYKAISVGSNPIPIGTAYAVWTGIGAVGGVMAGIFIFNEPATFWRMFFVFTLIASVVGLKVVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X339</accession>
    <name>C6X339_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02419"/>
    <dbReference type="EnsemblBacteria" id="ACU08852">
        <property type="protein sequence ID" value="ACU08852"/>
        <property type="gene ID" value="FIC_02419"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02419"/>
    <dbReference type="eggNOG" id="ENOG503175Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1509486_0_0_10"/>
    <dbReference type="OMA" id="CTTKEST"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973409" evidence="1">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="176" mass="19811" checksum="7F7AB6B77404AF8C" modified="2009-09-22" version="1">MRSILKILPFLFFFTTFTVQAQQIVKNDTISGTPLVIRMDEKVDALLGNLEDKCTSNIGNSSGNTGSDSPRTPVIAVPERELSKAEICRRNPRIMGYKIQIAVVKSNEEAREVGMYFRRRFPNMKVEIDASLRPNYKVMAGSYLTKQSAASDLAKVKPFFKSAMSVQYRVFCVEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A9</accession>
    <name>C6X3A9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807206.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02489"/>
    <dbReference type="EnsemblBacteria" id="ACU08922">
        <property type="protein sequence ID" value="ACU08922"/>
        <property type="gene ID" value="FIC_02489"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02489"/>
    <dbReference type="eggNOG" id="COG5473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150264_0_0_10"/>
    <dbReference type="OMA" id="KMADCAD"/>
    <dbReference type="OrthoDB" id="1350329at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="243" mass="27444" checksum="DD3B68AEC0E2B176" modified="2009-09-22" version="1">MNSFQEFSENHQRRSFSEIITHAFETYKGIFLYALLAMVLYTLVSIAVEPASGFDSDGFSKEIIDADGDFSQMDIWAFPGFKFYYGLSGIVTLLLAPLFVGIIYMANKYNFKQPLHVGDLLIGYKQNFINILIYSLLSSVIITFSFLLCFLPVFFVLPLLLLGYPILLFENASFTEAFQKSFRIAKEHYGTFLLTSFVGLLISLAGIFLCIIGIFATLPFYMVVMYSAYCAYCGSPRPVNPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C0</accession>
    <name>C6X3C0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807217.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02500"/>
    <dbReference type="EnsemblBacteria" id="ACU08933">
        <property type="protein sequence ID" value="ACU08933"/>
        <property type="gene ID" value="FIC_02500"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02500"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_2_10"/>
    <dbReference type="OMA" id="TSPLWGM"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="150"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="294" mass="31922" checksum="CCD37F54DD4CDD7D" modified="2009-09-22" version="1">MNSEREKWVLLIGLTVIWGSSFILIKKSLEHFNPYEVGALRVLIAGLILLPFALMNIKKFPRKNVKWLILAAVTGNFVPMFLFPIAETAVSSSIAGIVNSMMPIFVIIVGALMWKFQTTKRQIIGVVISFSGACILAFSGGEGGEFKLVPVLLLLLATLCYAVSTTTVKSKLNHIPAKILSAFVFSFVLIIPSAVSLVLAGFFNDLENDQNLWAGLGFVSLLSIFGTGLAMMLNYRLLSISTPLFASTVTLLMPVVAIIWGVIDGETLTPIQCIGAVIILAGLIFLRQRAVICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F9</accession>
    <name>C6X3F9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807256.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02542"/>
    <dbReference type="EnsemblBacteria" id="ACU08972">
        <property type="protein sequence ID" value="ACU08972"/>
        <property type="gene ID" value="FIC_02542"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02542"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_10"/>
    <dbReference type="OMA" id="TWMYRIV"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="185" mass="22351" checksum="B2488992A73E460C" modified="2009-09-22" version="1">MKIKEEEIIRLMSGEKTREKGVRMMMDAYQSRLYWHIRRIIVDHSLAQDVLQDSFIKAYQNFHQFKQDSQLYTWLYRIATNESLQQLNKLKRMQKTDEDPEYYLQNMVADNVSPEAEDIQILLQKAIHSLPEKQKLVFTMRYYEELPYEDMSQILDMSVGTLKTNYHYAKQKVEDYIKLNYNDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3G9</accession>
    <name>C6X3G9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GldH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807266.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02552"/>
    <dbReference type="EnsemblBacteria" id="ACU08982">
        <property type="protein sequence ID" value="ACU08982"/>
        <property type="gene ID" value="FIC_02552"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02552"/>
    <dbReference type="eggNOG" id="ENOG50313I2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109250_2_0_10"/>
    <dbReference type="OMA" id="KLWYKEN"/>
    <dbReference type="OrthoDB" id="1850223at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020018">
        <property type="entry name" value="Motility-assoc_lipoprot_GldH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14109">
        <property type="entry name" value="GldH_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03511">
        <property type="entry name" value="GldH_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970615" evidence="1">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="158" mass="17959" checksum="1DB0B34B15261B5C" modified="2009-09-22" version="1">MMTVHKLWPALIILLIFSSCGSSSDTVDMKNLDGNWGKKAEQKFSFEIADAQTPKNIIFVVRNNNEYPYSNIRLIVKMNEHQSKSVMRTDTLNYILAQPDGTWLGKGFGDTKEIMFQYKLNYKFPRNGGYTIGITQAMRTDSLKGIEDIGVKIETPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I0</accession>
    <name>C6X3I0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807277.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02563"/>
    <dbReference type="EnsemblBacteria" id="ACU08993">
        <property type="protein sequence ID" value="ACU08993"/>
        <property type="gene ID" value="FIC_02563"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02563"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173284_0_0_10"/>
    <dbReference type="OMA" id="INTILYI"/>
    <dbReference type="OrthoDB" id="1942353at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025698">
        <property type="entry name" value="2TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13239">
        <property type="entry name" value="2TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="2TM" evidence="2">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="11047" checksum="49A9D26C7D548786" modified="2009-09-22" version="1">MEDFNSNDRKYQEAKKQVKAIKGFYIHAAVYILVNLFIVAQNVKGGASAGDMDNYWTAIFWGIGLLAHGIGVYVPKFILGRKWEEQKTRELMDKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M2</accession>
    <name>C6X3M2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ordered locus">FIC_00552</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782157.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00552"/>
    <dbReference type="EnsemblBacteria" id="ACU07010">
        <property type="protein sequence ID" value="ACU07010"/>
        <property type="gene ID" value="FIC_00552"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00552"/>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_10"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="OrthoDB" id="923547at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="56"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="171"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU07010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="329" mass="35725" checksum="2653B2A7DB421D6C" modified="2009-09-22" version="1">MSNTYQSAGVNKEEGYKTVDKIKSAVAETHNKNVLNNLGSFGAFYEIAGYKNPVLVSGTDGVGTKLKVALDSKNYSSIGIDCFAMCANDILCHGAKPLFFLDYLACGKLDSDIAAEIVMGMVKACKDNNCALIGGETAEMPGMYKPGDYDVAGFCVGIVEKDQIIDGSQIRVGDRIIALPSSGFHSNGFSLVRKVFEDFDEVFEGKPLHETLLIPTKLYYTEVHKLLDEVEVAGIAHITGGGIIENIPRIIPEGLCAQIETSKIKIPSIMLELEKRGNIERHEMFGTFNMGVGMVIVVDAKHAEKVLDLLDSAYEIGEITQAESKIELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Q3</accession>
    <name>C6X3Q3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative alpha-dextrin endo-1, 6-alpha-glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.41" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00586"/>
    <dbReference type="ESTHER" id="flab3-c6x3q3">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07041">
        <property type="protein sequence ID" value="ACU07041"/>
        <property type="gene ID" value="FIC_00586"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00586"/>
    <dbReference type="eggNOG" id="COG2819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039834_1_0_10"/>
    <dbReference type="OMA" id="CKEALAD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="397" mass="46533" checksum="C745964599C11F74" modified="2009-09-22" version="1">MQHSAAPALNISLLLNLQKPEQIQMKFTVISHEEDDRPVYITGNFNKWNPRDPLFELREVGRNTYTIDIDDEVLPEHIEYKFTRGGWENGEIDRHGNILRNRKADKSTAEKTDTAERWRTNWAPFKEEFSPIVEIISEDFYIPQLNKTRKIWALLPYNYHESTSAYPVLYLHDAQNLFNEGSSFGNWEIDKKMSILAEYGRGDLIIIAIENAREDRIKEYVLDDHSITENAEGKKYVRFLADTLKPYVDAHFRTLPEREFTGIGGSSLGALISIYSGFLYPEVYSKLMIFSPSLWINPENNYPQMNFSKPYGIKVYLYGGENEGSEMTERIAEFERTMETWETSHSLQFDFRVSINPEGKHQEFYWSQEFPRAMEWLFFDSDEDPKDLSEKAMKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3R1</accession>
    <name>C6X3R1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00594"/>
    <dbReference type="EnsemblBacteria" id="ACU07049">
        <property type="protein sequence ID" value="ACU07049"/>
        <property type="gene ID" value="FIC_00594"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00594"/>
    <dbReference type="eggNOG" id="COG4898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133735_0_0_10"/>
    <dbReference type="OMA" id="HQVIEWL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023204">
        <property type="entry name" value="SP1917_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014580">
        <property type="entry name" value="UCP033199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09966">
        <property type="entry name" value="DUF2200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033199">
        <property type="entry name" value="UCP033199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="14467" checksum="982A8E1C32FE7123" modified="2009-09-22" version="1">MSFNVKMKAANTRIYRMSFASVYPHYIAKAEKKGRTKAEVDEIIFWLTGYDHDGLQTIIEDQTNFEDFFNQAPKLNPGVSKITGVICGYRVENIEDPLMQKIRYLDKLVDELAKGKTMDKILRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S8</accession>
    <name>C6X3S8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782213.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07066">
        <property type="protein sequence ID" value="ACU07066"/>
        <property type="gene ID" value="FIC_00611"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00611"/>
    <dbReference type="eggNOG" id="ENOG5033FIU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281616_0_0_10"/>
    <dbReference type="OMA" id="WIFRIEK"/>
    <dbReference type="OrthoDB" id="2091467at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="215" mass="24904" checksum="F3C3C2DDC43BF949" modified="2009-09-22" version="1">MTTQTTDIKREFKTPLGVVRCGLICNRQDNAIETKKYENGSSEIFNTDGHKIEIVSFKIRVPLYNGDTLTDSFGWIFRIEKTADVDEKIETYCLLDKINDEVTYDTATGEHLDAIQADSNEWTLHIGTEDGEVLNSRAENDDWFPPRLKHKVDFYQSITEMKQNGFVTKIPDLKNGEKIHIQYLTAYDKKDEQKVNTWLAVDEFKGKLENWIGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3T3</accession>
    <name>C6X3T3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07071">
        <property type="protein sequence ID" value="ACU07071"/>
        <property type="gene ID" value="FIC_00616"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00616"/>
    <dbReference type="eggNOG" id="ENOG50343VD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459268_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="199" mass="22691" checksum="4E169ACCF8C265B9" modified="2009-09-22" version="1">MCSETRPNAKPENVMCNRMKTIPITILFAFITILLGCSKESKTIKEDDEKILINAKEILENKNLAGLITKLENTELTEETDINKIPKVILNFLNAILEDKPIANPHENWNPTDVILDKKLPRRKLQYFGSGKNIALMNYFKGGIGKSTIILIFEFNEKKVTNFWCGSVLVDLNNKETTLKYLKANINKERGLNTNILSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3W8</accession>
    <name>C6X3W8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YceI like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782252.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00651"/>
    <dbReference type="EnsemblBacteria" id="ACU07106">
        <property type="protein sequence ID" value="ACU07106"/>
        <property type="gene ID" value="FIC_00651"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00651"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_10"/>
    <dbReference type="OMA" id="RFSYSHF"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973434" evidence="1">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="190" mass="21069" checksum="E1F405BF88F0B55E" modified="2009-09-22" version="1">MKKLLSLLAVAMFSVLSFAQLTLKSDGAHSRIQFTIVHLGINDITGSFDKASLTINADEKNFVNSKLTFSADVNSVNTHIEARDKHLKNADFFDVEKYPTMDFTSTSLTKVKNNYYTLKGNLTMHGVTKPVTLNLLYRGSTVNANSKKTTYGYQITGSVKRSDFDFGTKYPEAMLSDLVSIKGDFELAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X0</accession>
    <name>C6X3X0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dithiol-disulfide isomerase</fullName>
            <ecNumber evidence="2">5.3.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.4.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782254.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00653"/>
    <dbReference type="EnsemblBacteria" id="ACU07108">
        <property type="protein sequence ID" value="ACU07108"/>
        <property type="gene ID" value="FIC_00653"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00653"/>
    <dbReference type="eggNOG" id="COG2761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_2_10"/>
    <dbReference type="OMA" id="KPTNTFD"/>
    <dbReference type="OrthoDB" id="996965at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="234" mass="26384" checksum="A900A15A52C43517" modified="2009-09-22" version="1">MKVDIWSDIRCPFCYVGKKKFEKALAQFPEAENVEIIWHSFQLDPNLETQHDRNPYEYFSEAKRIPVEQAKAMHEHAKNAGREAGIEFNFDESKIANSFKGHLLIQLAKTQGLANQMEEALFAAQFIKGQNIDDEQTLYDIARSVGLSEEQTQNALKSDEFAHAVAQDGLMARQLGINAVPFFVFNDKYGVSGAQQPEHFLEVLSKSWEEFSAGDKGLQIISRGESCDTDGNCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X432</accession>
    <name>C6X432_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782316.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00715"/>
    <dbReference type="EnsemblBacteria" id="ACU07170">
        <property type="protein sequence ID" value="ACU07170"/>
        <property type="gene ID" value="FIC_00715"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00715"/>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008305_0_0_10"/>
    <dbReference type="OMA" id="MPTYQLG"/>
    <dbReference type="OrthoDB" id="946896at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="853" mass="95842" checksum="3317E314809244C4" modified="2009-09-22" version="1">MAKNRKLILIIGSLVAFAVLALLYANPVLLGKQLYQHDIVQYKGGAKELLDFRAQNGKETYWSDSMFGGMPTYQMGAQFRGDVIKKVDDVLNFLPKPANYIFLLFSGFFLLGLVAVRNWKYALLGATFFGLSTYFYIALAAGHNGKIHTVAYFAPLLAGILLVYIRKKYVIGFIVTALFMGLQIAANHPQMTYYLFIALGFLFLSELVRAVQGKTDWKHFGISSAVLALAFVLGVGMNSQRIMANAEYVSETVRGKQILDTDTHSSGKSGMDKESMLMWSYGKMETLNLFIPRLMGGSSNEEGSEEMMARVQEMVQANVSSQEEMDQISKGFGSLTYWGEQPGTSGPAYQGAVVVFLAILGFFFAWKKYRYWILGASILTILLAWGSNFLIISDFFIDFVPFYNKFRAPSSILVVVELLFPLIAIVGLYRFFNSDENTETRAENILTDNYKKKILTYVSAATLGITLILLIFGKSVLGFHTAVEKTYLPPYLLDFLIDERYSMFRIDAIKALMYVGITAAVLFLGLKKKLSQNVVIVVIGLVSLFDLWSVNKRYLNNENFIDKTFTENPFQTETSELLMQKVGDNSSLQALLAGANVNKVLETIAEKDQTHYRVYNQVLGTFSETNTSYFKPSVGGYHAVKLRRYDDLINEYFGKMDTAKVPRILNMLNTKYMIFGDTAEPQVVPNPQANGNAWFVSDVKFVKSANEEIKLIGELDTKKIAVVADADKAYFNGKTIAPDAAAVLNLTKYQANELEFKSQSKTPQLAVFSEIYYPKGWKIFIDEKEVPYIKANYLLRAVHVPAGNHMVKMIFEPEVIQTGKIISMIAFGIFIILSGLGIFFLYRKRDKSRMAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X456</accession>
    <name>C6X456_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative deoxyribonuclease YcfH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782340.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00739"/>
    <dbReference type="EnsemblBacteria" id="ACU07194">
        <property type="protein sequence ID" value="ACU07194"/>
        <property type="gene ID" value="FIC_00739"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00739"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_10"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="257" mass="29165" checksum="D218B2FDE84FF114" modified="2009-09-22" version="1">MIDTHTHLYSEEFSSDRDEMIQRAVAAGVTKFYLPAIDSSTHANMLALEDQYPDKVIAMMGLHPCSVKAETWKKELALVEDYLSKKNFAAIGEIGIDLYWDKTTLDIQIKAFERQIDWAIERDLPIVIHTRESFDEVFAVLERKQHPKLRGIFHCFSGNLDQAKRAIDLNFILGIGGVVTFKNGKIDQFLHEIPLEKIVLETDSPYLAPVPHRGKRNESAYIGLVAGKLVDIYGKSFAEIDKITTENAERVFSPKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X466</accession>
    <name>C6X466_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782350.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00749"/>
    <dbReference type="EnsemblBacteria" id="ACU07204">
        <property type="protein sequence ID" value="ACU07204"/>
        <property type="gene ID" value="FIC_00749"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00749"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065795_0_0_10"/>
    <dbReference type="OMA" id="NDPGYGL"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="272" mass="29308" checksum="AC132C6345F335B5" modified="2009-09-22" version="1">MKNLSTSSQEFRFNEILFENRNKSYGAYVLRNEEGKTMQKALFIGLSLLAAVSIAPLLLSTLGAAEEIPQPVPPEHVLKNVDRPEALPPVATPVMPPRSPETTVSIEMPTPAVNPPVETPPASLTQIKDANIGTENVIGEPASQTYTPPVSTSGTAAPTQPVPPVSVNNDPVSVVDVEAGFVGGINTFRTKVVQNFGTDQFEDAAGLMQTTVTFIVEKDGTISNIKANGKNAQFNAEAEKTVKKVKGKWSPAKLRGENVRSYFKFPISMQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X495</accession>
    <name>C6X495_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782379.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00780"/>
    <dbReference type="EnsemblBacteria" id="ACU07233">
        <property type="protein sequence ID" value="ACU07233"/>
        <property type="gene ID" value="FIC_00780"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00780"/>
    <dbReference type="eggNOG" id="COG0567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_10"/>
    <dbReference type="OMA" id="IMIDQYI"/>
    <dbReference type="OrthoDB" id="29166at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="5">
        <location>
            <begin position="588"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="932" mass="105392" checksum="E01CB28A7156DFE8" modified="2009-09-22" version="1">MDKFSFLNAAHSQLIEDLYQQYLKYPDSLEPSWKAFFQGFDFALETYEDEIAGSSQAPSVVRAATQSAAKGEIPEDIQKEFKVLNLIEGYRQRGHLFTNTNPVRARRNYEPTLAIENFGLSQSDLQTKFNSATETGLSAAASLQDIIKHLEKIYCESVGVEYMHINNVEEKKFIRKWLQVNENQPQLTASEKTDILQKLNQAVAFESYLHTKFVGQKRFSLEGGESLIPALDQLITRSSQLGVDEVVLGMAHRGRLNVLTNIFGKSYKQIFSEFEGKEFEEDVFSGDVKYHLGSSKKIKTASGEEVAINLTPNPSHLETVAALVEGICRAKVDNKYKDYKKVLPIVIHGDGAIAGQGIVYEIAQMMTLEGYKTGGTIHIVINNQVSFTTNYLDARSSTYCTDIAKVTESPVMHVNADDVEAVVYAMKFAADFRANFGKDVYIDLLGYRKYGHNEGDEPRFTQPNLYKLISKHPNPREIYKEQLIKEGIVSDEILKKMETEFKTLLDADFDASKEIERNTMNIFMEDDWKDYTMGARGVMQNEVETGFDLDKLKELALKMSTLPADKKFINKTTRLFDNRKKMIEGNSLDWALGEWLAYATLLTEGNNVRISGEDVERGTFSHRHAVVKTEDTEEEYIPLRHISESRFDIFNSHLSEYGVLGFDYGYAMASPNTLTIWEAQFGDFVNGAQIIVDQYLAAAEEKWKIQNGLVMLLPHGYEGQGAEHSSARLERFLGLCANENMAVANVTTPANYFHLLRRQQKWAFRKPLVVMTPKSLLRHPKVVSPLEDFANGSFQPVIDDQTAVADNVDKLVLCSGKIYYELLAKQEERKCDNIALVRIEQLYPLHKESIDAVLSKYGSRKKIIWAQEEPENMGAWAYILRNLRDTGIQVIAPVSSGSPAPGSHKMFERNQNNVLNQVFDCNDEPATRPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4A9</accession>
    <name>C6X4A9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ordered locus">FIC_00794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782393.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00794"/>
    <dbReference type="EnsemblBacteria" id="ACU07247">
        <property type="protein sequence ID" value="ACU07247"/>
        <property type="gene ID" value="FIC_00794"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00794"/>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061495_2_0_10"/>
    <dbReference type="OMA" id="EFCYKND"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="27315" checksum="8B072755C4FC053B" modified="2009-09-22" version="1">MKKGAMLYEGKAKQVFETDHPDEVIVRFKDDATAFNAQKRGSVDLKGEMNNAITTLIFEYLNKKGIPTHFIKQIDEREQLVKKVNIIPLEMVVRNYSAGSMAQRLGVAEGIKSPVTIFDICYKKDELGDPLINDHHAVFLGAATYEELDEMYELTSDINDILIELFDSMNIILVDFKIELGKTSNGKIILADEISPDTCRLWDKDTMKKLDKDRFRRDLGGVTEAYVEIYERLKKVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H4</accession>
    <name>C6X4H4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782458.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00859"/>
    <dbReference type="EnsemblBacteria" id="ACU07312">
        <property type="protein sequence ID" value="ACU07312"/>
        <property type="gene ID" value="FIC_00859"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00859"/>
    <dbReference type="eggNOG" id="COG4696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097934_3_0_10"/>
    <dbReference type="OMA" id="IPCWDEV"/>
    <dbReference type="OrthoDB" id="1654302at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11530">
        <property type="entry name" value="NTP-PPase_DR2231_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033653">
        <property type="entry name" value="NTP-PPase_DR2231-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023292">
        <property type="entry name" value="NTP_PyroPHydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="158" mass="17950" checksum="9D8691533DDF149D" modified="2009-09-22" version="1">MEKIDSLNQVAEFHRTFNAPILDTPQIPSKERCELRLTLLQEELNELREAIADDNIVEVADALCDLQYVLSGAVLEFGLGDKFVELFNEVQRSNMSKACSTQEEADETIAFYKEKGEEAFSEISGSKINVHRKSDYKVLKNKYYSPADLHMILTDKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H7</accession>
    <name>C6X4H7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00862"/>
    <dbReference type="EnsemblBacteria" id="ACU07315">
        <property type="protein sequence ID" value="ACU07315"/>
        <property type="gene ID" value="FIC_00862"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00862"/>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019348_2_1_10"/>
    <dbReference type="OMA" id="WHYGDLP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973576" evidence="1">
        <location>
            <begin position="31"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="304"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="635" mass="71214" checksum="67F27D4A148BB6D4" modified="2009-09-22" version="1">MIKLAQLNYYCMKRFLFLALLLPFSGFAQAPSGYYDGTAALTGYALKSKLHEIISEKNINWHYGDLPAFYNQTDLDRYYDHGVNNSTILLDIYSEIPAGADAYEYTSANLIGSASAEGLGWNREHMVPQSTFNSSYPMYSDLFYVIPTDARINQLRSNYPYGKAGSLNYYTFRNGSKISRNGTPNSGYTGRVYEPVDEFKGDIARSLLYFAVRYEGKLSSFNFYNGTSAANDTSPFDGTEEKAFENWYIAMLLQWHQLDPVSPRETDRNNVVFTLQKNRNPFIDHPEWVTAIWSQTADAVAPQAPTNLQLQQNSAYFVNLSWATAPETDVLGYKIFQNGVLVATTRDTQVTIDHLQPATTYNFTVKAYDNGYLESSDSNILEVSTLASDVFAKDLMITKYIEGSGQNNAIEITNKTGHPVNLNKYRLSIQFYNGTNANYYFPDPYELEGTVQNNEPFVVLNPYSNLSCITNDEARFVTAAPQLTFSGSQYLELRYASTTIDAIGTRSADNFAVLGNVSLYRLNSVSQPNSSFTLNEWQTYPVNYCENIGTLAASGVATNQPKYSLYPNPLHGNTLYVSGQNLEKVLNIAVYDLSGKRIIDRVSPFKNTNAIDVGTLKSGVYILKIDDQSLKFIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4S0</accession>
    <name>C6X4S0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00957"/>
    <dbReference type="EnsemblBacteria" id="ACU07408">
        <property type="protein sequence ID" value="ACU07408"/>
        <property type="gene ID" value="FIC_00957"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00957"/>
    <dbReference type="HOGENOM" id="CLU_2287375_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="101" mass="10956" checksum="0A09AB766FBF72BB" modified="2009-09-22" version="1">MSHQKFYMKKIILGLSLAGLFMSCQKVQEGSNKSVMRLNNVAPEGLPYNADAQGVRTKQLAAPRTQTAPATVVVTDSTKMPDMKEVASPTDATKSPQMDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4U5</accession>
    <name>C6X4U5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate dehydrogenase complex, dehydrogenase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782579.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00982"/>
    <dbReference type="EnsemblBacteria" id="ACU07433">
        <property type="protein sequence ID" value="ACU07433"/>
        <property type="gene ID" value="FIC_00982"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00982"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146109_0_0_10"/>
    <dbReference type="OMA" id="VKGWSGS"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="147" mass="16834" checksum="CEC5AB71740BD3D3" modified="2009-09-22" version="1">MATLNYEIIINAPAKKVWDALWDEKTYPQWTQFFTPDSKFKTDWQIGGETLFLDGQQNGMYSTIKSISEPTEVIFSHLGMVRNGVVDTATVNQLEWSGAEEKYFLREIDPNTTELRAEVHTTGEMQNMMNEGFNRGFEVLKKLVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V8</accession>
    <name>C6X4V8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07446">
        <property type="protein sequence ID" value="ACU07446"/>
        <property type="gene ID" value="FIC_00995"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00995"/>
    <dbReference type="eggNOG" id="ENOG5033I78">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265382_0_0_10"/>
    <dbReference type="OrthoDB" id="2123738at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970675" evidence="1">
        <location>
            <begin position="27"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="218" mass="24650" checksum="67E35AFFC9DF8772" modified="2009-09-22" version="1">MAEIYIFRKKIYMTKLLTLLSLAAFGLGFSQNFSPAQYPKGVYETYEDFRTKTPSSDPGISAPITDDQIAFRFNNLDDKGKKLKKAFAISDGKDVYIHVVNLIKKFNSEDKGQGYDGGIYYLKAENKGGYLFVRDYFTSNSAAMWGGIIAATAARRTKGVIYDEEKESFNLFKNIEEFKTFMEVNHPNVSLDLEKGKGESKLDEGEIEAKNLEFIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4W7</accession>
    <name>C6X4W7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782601.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01005"/>
    <dbReference type="EnsemblBacteria" id="ACU07455">
        <property type="protein sequence ID" value="ACU07455"/>
        <property type="gene ID" value="FIC_01005"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01005"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651687_0_0_10"/>
    <dbReference type="OMA" id="FIDMSAY"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="420" mass="46064" checksum="AE3C8726C93A9C4C" modified="2009-09-22" version="1">MHKFLSTFLFIGVLVSSQQQWSTFSYPPATQGRYDDVFFLNENLGWAARGGSGAVFKTTNGGANWTQLSLPNPNNEYYRNIEFLDENIGFLGTLNNSFYKTTNGGATWQKVQNISPYPEAICGLDTIGTSTVYGCGAWFQPAYIIKSTDSGNTWQFIDMSAYATALVEILFITENLGFVSGSDDQGAVILKTLNGGATWTKIYGSNIPNEYVWKMQILPGTDNMRMFCSIESVAPNSGKLLKTVDGGATWETKNFPDVDVQAVGFVSSTKGWMGGHHTGFHETNDGGETWTNLGIGGSLNRIFFLSETLAYASGNNIYKMTGSGLSVAGVGDQSVKELKVDIAPNPVTDVLNLKIHYEHSDHIIIALYDTSGKFLEYILKGDVPGKGIKNYSLKFDYPAGVYFLNVHSNLGRRSIKIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z1</accession>
    <name>C6X4Z1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine specific DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782625.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01029"/>
    <dbReference type="REBASE" id="21508">
        <property type="entry name" value="Fba3519ORF1029P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07479">
        <property type="protein sequence ID" value="ACU07479"/>
        <property type="gene ID" value="FIC_01029"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01029"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009503_0_0_10"/>
    <dbReference type="OMA" id="ENVFNIM"/>
    <dbReference type="OrthoDB" id="45009at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="378"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Type_ISP_C" evidence="2">
        <location>
            <begin position="701"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1063" mass="123451" checksum="03B83D04048B69C7" modified="2009-09-22" version="1">MTIQQYIDNLNRLYQTGNAREHSYRGDLQNLLSTLLPEILVTNEPARIECGAPDYVLTRGTNHIPVGYIEAKDIGVKLDSKVLNEQFDRYRLGLSNLIITDYLTFEFYRDGEKYKTVIIAGNIEGKIVSRPENFPEFESLIKNFVQTVSQTIKNPQRLAEMLAGKARLMADIIEKSLNADDEHESSSELKNQMTTFKNMLIHNIDNKAFSDIYAQTIAYGMFAARYNDPTLETFSRLEAANLIPKSNPFLRKLFQDIAGFDLDDRLVWIVEELVQIFLATDVEKIMKNFGKATKMEDPIIHFYETFLAQYDKNLRKVRGVWYTPQPIVNFIVRAVDDILKDEFNLQQGLADTSKTKIKVDSQIPDARSATGFRLVEKEVHRVQILDPATGTGTFLAETVKHIHSKFKGMEGMWSKYVKNDLIPRLNGFELLMASYAMAHLKMDMLLKETGYKSDDEQRFRIFLTNSLEEAHPDSGTLFSSWLSDESTQANKIKKETPVMVVMGNPPYSGESANKGKWIMDLMEDYKKEPGGKEKLKERNPKWINDDYVKFIRFAQYFINKNGTGILAFINPHGFLDNPTFRGMRWNLLKEFDKIYTIDLHGNLKKKEISPDGSIDQNVFDIMQGVSVNLFVKTGNKKENELGQVLHYDLFGKRDFKYQFLNENNISTIPFNLLQNTAPNYFMVQKDFGVQKEYDHGFKINDLFFLNSLGLTTARDHFTIHNSKQAVEKVINEFLLLDDETARTKFRLGADVRDWQINFAKKDLNKNYPDQGSFEEVAYRPFDTKWTYFTGNSKGFHCFPRSEVMNNLKFPNLGLSLIKRARSDSFNTPVISNKITDKGISSSLDNAYVFPLYLYNEISSQTTTEETPSRVPNLNMEIVKQIGEQLNLYFSPERPDYSKQTEETNQFYPEDILDYIYAVLHSPKYRETYKEFLKIDFPRVPYPTDPKQFWKLVELGTQLRELHLLESEKVNDFISSYPEDGSNIVEKLIYKDGKVYINKTQYFDNVPEVAWNFYIGDYQPAQKWLKDRKDRELSYEDIVHYNRMIVALTETDRLMREIDNIFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Z9</accession>
    <name>C6X4Z9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01037"/>
    <dbReference type="EnsemblBacteria" id="ACU07487">
        <property type="protein sequence ID" value="ACU07487"/>
        <property type="gene ID" value="FIC_01037"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01037"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107963_0_0_10"/>
    <dbReference type="OMA" id="MATWLET"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973697" evidence="1">
        <location>
            <begin position="33"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="23878" checksum="D7E4B8A2CA4F0685" modified="2009-09-22" version="1">MFSPKISIFKKKLFMKKLILSAFIAASVSTYAQISLPAASPRQTVEQQFSTSKITVDYGRPGVKGRKVFGELVPFGKVWRAGANSATKITFEQPVNFGGKTVAAGTYGLFAVPTEKEWKVILNKDAQQWGAYTYDEKLNVVEITVPVQKLAEKQEWFEIELNPVDDMAMDMVIKWDMAKVTVPVKVANPELTLKVMDKLKEIRQLERDAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X502</accession>
    <name>C6X502_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805775.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01040"/>
    <dbReference type="EnsemblBacteria" id="ACU07490">
        <property type="protein sequence ID" value="ACU07490"/>
        <property type="gene ID" value="FIC_01040"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01040"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_1_1_10"/>
    <dbReference type="OMA" id="VWEQHPN"/>
    <dbReference type="OrthoDB" id="1374795at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="179" mass="20937" checksum="7BE0B0C64F566E3C" modified="2009-09-22" version="1">MNFSIQPLLENENFQLLPLKESDFEPLYLVASDPKVWEQHPNKERYKKDVFENFFTGAIESKGAFLVVSRTTGEVLGCTRFYDYDPDTKSILIGYTFYGRSSWGKNVNPQVKKLMLDYIFQFVDSVIFHVGKVNIRSQKAMERLGAERVGEEEIAYFGELPQINVIYEIRKESWLRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X508</accession>
    <name>C6X508_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01046"/>
    <dbReference type="EnsemblBacteria" id="ACU07496">
        <property type="protein sequence ID" value="ACU07496"/>
        <property type="gene ID" value="FIC_01046"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01046"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350462_0_0_10"/>
    <dbReference type="OMA" id="SGSHERY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="3">
        <location>
            <begin position="500"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="833" mass="93562" checksum="14AC51B57B1BAD3D" modified="2009-09-22" version="1">MNNRVRKLFLKFPYFRTFVKYPFVMQETYIETEEISFQDFRNSVIEDYRLGRISREMSYLGRREVLTGKAKFGIFGDGKELPQLAMAKVFKNGDFRSGYYRDQTFAMAIDAVTVESFFAQLYADTSVEREPASAGRQMNGHYATRSLNADGSWKNLMAQKNISSDISPTAGQMPRLLGLAMASNIYKSVSFEGSEKFSNGGNEVAFGTIGDASTAEGHFWETLNAACALQVPMIVSIWDDGYGISVPTQNQRAKADIAEMLSGFQRNEGENQGCEIIQVKAWDYPSLLDAYAKAEHFARTESVPVVVHVIEVTQPQGHSTSGSHERYKNEERLKWEGEFDGLNKFKEWILNYSIEIEGKEQQLTTSEELEKIEEEAKKFVKEGQKKAWENYQATIKNLKDSVLPLLDSLGRQNPEILSEIEKFNKIISVGKKDIFHVARKSLMLTRGKQSDARQALQSKLDEIYAVEKDNYSSDLYSKSEWKATNVKEIAPVFTDESETVDGRVVVRNNFDKIFEKYPETLVFGEDAGNIGDVNQGLEGLQEKYGELRVADTGIREATILGQGIGMAMRGLRPIAEIQYLDYILYCLQGMSDDLATVQYRTKGGQKAPVIIRTRGHRLEGVWHSGSPMAGIINLSKGILILVPRNLTKAAGFYNTVLQSDEPALIVECLNGYRLKEKQPDNIGEFTVPVGKIEVTKEGSDVTLVTYGSTWRLVMEAAAELEQMGISAEVIDIQSLIPFDLSNEIAQSVKKTNRLVVIDEDVEGGTSAFILQQVVEKQKAFRFLDSDPLTICAENHRPAYGSDGDYFSKPSVDDITEKVYALFNETNPDRFPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X524</accession>
    <name>C6X524_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805797.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01062"/>
    <dbReference type="EnsemblBacteria" id="ACU07512">
        <property type="protein sequence ID" value="ACU07512"/>
        <property type="gene ID" value="FIC_01062"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01062"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043019_0_0_10"/>
    <dbReference type="OMA" id="NIGVINM"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970684" evidence="1">
        <location>
            <begin position="19"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="462" mass="50461" checksum="C1035CFBB2E11A80" modified="2009-09-22" version="1">MKKLFLSIALVSATLAVAQKKEIAAAVKAADAGDIAGTNAQIAAAEAAMGGKTYLVEPAVLEQYYYAKGMALLKSGKNAEGASYLAKMSDLGKNKIYTGKDSSKNKVYYVGKAEADKSGVQGLKEETYTPALSAKIGNTINPLIEKANKTAMDAYSAKNYSVAAPKFKEVYDLLKAGGQDNKQYLYYAGLNYALADKKSEAVDVYNELISSGYTGIQTTYSAKNKKSGELEPMDKVTWELNKKMGATSEYSDFKTETSPSIERELYETNAALLIESDKNEDALKLIETGLKKFPSSVKLSELQGTAYYKSGKMDEFVANLKTQTEKNPTDANNWYNLGVLQSKNPGSEADAIASYKKAVELKPDFVQAWQNLTYTVMGDDAKAIDDYNAAKKAGKTDQANKIIEARRERLAAALPFAEKWYESDQKNIDAVTLLKGLYMSNKKEAKFQEFKAKEAAMQAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X526</accession>
    <name>C6X526_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805799.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01064"/>
    <dbReference type="EnsemblBacteria" id="ACU07514">
        <property type="protein sequence ID" value="ACU07514"/>
        <property type="gene ID" value="FIC_01064"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01064"/>
    <dbReference type="eggNOG" id="ENOG502Z7JZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101335_3_0_10"/>
    <dbReference type="OMA" id="PIKWTGP"/>
    <dbReference type="OrthoDB" id="1735899at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="143" mass="16415" checksum="252A00774243D455" modified="2009-09-22" version="1">MPPLKTISRYHFIAEWGGNRVEFTEISGLEIYIDVISMRNGSSSENSELKIPGITKFPEIVLKRNIVQGDQQFFDWIRTNSFGTVERRDVVIRLLDYQHQPVMMWRVRNAFPSKYIGPVLLSGDSNLATESLVLSHDGLDLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X545</accession>
    <name>C6X545_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805818.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01083"/>
    <dbReference type="EnsemblBacteria" id="ACU07533">
        <property type="protein sequence ID" value="ACU07533"/>
        <property type="gene ID" value="FIC_01083"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01083"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1254110_0_0_10"/>
    <dbReference type="OMA" id="ANNTTHL"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="220" mass="25001" checksum="35A1D5C46B934917" modified="2009-09-22" version="1">MHTRVLIAEDHEIENIGVINTLKELNITDYAFTNYCDDAYKLIAEALKAGHPFDVLVTDLGFISDHRTQHLTSGQELIRDARALQPNLKIIAFSIEKRAAVIDELFREYGVDGFVSKGRNDGRELRSTLLKVMAGEKVMPQQILNSIRNTTQNLSSYDIQLLKLIAKGWKQKEIGDYFKENGIRPDSRSAIEKRLNDLRETLDAKNNIEMIVLCKDLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X546</accession>
    <name>C6X546_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component system sensor histidine kinase</fullName>
            <ecNumber evidence="2">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805819.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01084"/>
    <dbReference type="EnsemblBacteria" id="ACU07534">
        <property type="protein sequence ID" value="ACU07534"/>
        <property type="gene ID" value="FIC_01084"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01084"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_106_3_10"/>
    <dbReference type="OMA" id="NMKKHSQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="547" mass="62352" checksum="ADFDE55BCED4C3C9" modified="2009-09-22" version="1">MKIIHSPFLCILLLVFACSDKKEVSAADTLYKKAERLYDGGEYEQAFPGFYSAYQAYMTEQKPRDAAYSLVFLAIIQTEKGDFLGSNENLSKALKLSATDETLLTSVYNQFAINHNLLQNHENAVYWYHKALPLTEHQYYKLSIKNNIGIAYLKMGRYATAESLFKEIAGEDAIKDSISFHNRVADNFAYSKFLAGKNNPAEREMLTVLESRKRNGDRYGLTTSYSHLADFYKATDRRRSYEFAGAMHDNARITGNAADQLEALGKMIDAGEAARIKSLFGTYRKLNDSLQNSRNRSRHHFTSVIYEAEKNKADLLSSRNEILTQRLLIVALMIIAGLATVLFLKWRRKQAHKNEIAVRDTQLKYSKKVHDVVANGLYHTMVEIQNAEVLNRHKVLNSIEKLYEESRDIARDDFDTVIEQDFSVRLYEMLESYSSGRHRVLVIGNTWELWRRIAPEVQVEIFYVLRELMVNMKKHSEARTASLLFEETAGGIHIKYTDNGVGISDSAKWKGSGLRNMENRIDKLGGKINFGPNPSGGLITDILIPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X568</accession>
    <name>C6X568_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805841.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01106"/>
    <dbReference type="EnsemblBacteria" id="ACU07556">
        <property type="protein sequence ID" value="ACU07556"/>
        <property type="gene ID" value="FIC_01106"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01106"/>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_1_10"/>
    <dbReference type="OMA" id="KPQNTGY"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973477" evidence="5">
        <location>
            <begin position="26"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="75"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="341"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="463" mass="52496" checksum="0C924D68D3E09632" modified="2009-09-22" version="1">MKIQYTLKRIYTVSLGALLLSALHSCENLLDVNTPVSQTGSEQVFESVGTADAALSHLYTEIQAYSLLNGGSGGAGALLGAYTDDLISYDVYSQNGDMDIYQNVQGPSNISIKGVWTNAYSEIYTANAIINGVEKSTGIGEDDRRRIKGEALFVRTLIYYYLNQLFGDIPYTATTDYTVNQMLKKIPSAEVQLKIQEDLYSAAALLNDEYRNPERIYPNRKTAELLLATVLMTRQQYATAEALLRGIIQSPLYQWQPAVQETFKKNGQHILWQLKPLYPTQATNEVLLYYFESAHPTMYTLSDHLITSFSAGDLRKQWWTKEITVEQTAYYRADKYTRIFDNTDEYSIVFRLEEAYLLLAEALAQQGKLSEALPYLNAVKAKAGIPHVAPSVTKEQLLDEILAENRKEFFTERGIRFTTLKRMNRLSDLTSHKPNWKAHHQVWPLPFSELSLNPNLNPQNNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C9</accession>
    <name>C6X5C9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07617">
        <property type="protein sequence ID" value="ACU07617"/>
        <property type="gene ID" value="FIC_01167"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01167"/>
    <dbReference type="HOGENOM" id="CLU_3396629_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="31" mass="3482" checksum="3F0B5B18A5EFD372" modified="2009-09-22" version="1">MRHVKFAVVCVVLFIHKNELSKMLPKTAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5I6</accession>
    <name>C6X5I6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAPS_reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01226"/>
    <dbReference type="EnsemblBacteria" id="ACU07674">
        <property type="protein sequence ID" value="ACU07674"/>
        <property type="gene ID" value="FIC_01226"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01226"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027799_2_1_10"/>
    <dbReference type="OMA" id="GDSRFGC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017598">
        <property type="entry name" value="SulphurTrfase_DndC_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03183">
        <property type="entry name" value="DNA_S_dndC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="453" mass="52701" checksum="E29F79509FAE864A" modified="2009-09-22" version="1">MIIKNKKVEGIIAEIIDQYAYADKSDRPWIIGFSGGKDSTVLLMLVWIALQRIRQEMPFPYQLRRKVYVVCNDTMVENPIISNYVEDVLAKIAEAARDQDLPIFVQKTTPKLEETFWTNVVGKGYPVPNNAFRWCTDKLKIRPTSNFLLEQVDEKGEAIVLLGTRYDESKTRERSIRKHEVTGSRLSKHQTTANTYVYAPIKEMIVDEIWYIINAVKSPWGFDNSILFKIYADASADDYECPTVVVNKEHNSCGQSRFGCWTCTVVKNDKSMSSLVNNGQNWMEPLLAFRNRLVEGRNISENRYDTRRNGQEAVREDGTFNGNYTVEYRYKILKDLLLVQKEIQKERPHLTLINNQELIAIQVTWNRDGYFDHTVGELYKEIYNKDISTNNIKSLDDTERRILRDVCEEEPGYYHLIDNLIALQETKTLMISKYGLHNDVEKRIESFVNDQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K2</accession>
    <name>C6X5K2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805975.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07690">
        <property type="protein sequence ID" value="ACU07690"/>
        <property type="gene ID" value="FIC_01242"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01242"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_10"/>
    <dbReference type="OMA" id="HKRANIS"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="182" mass="20833" checksum="6CAB4B8402B624E3" modified="2009-09-22" version="1">MKSILETPRLLLRALHPADAESFYRLNLNPNVIRYTGNSPFKDVGEAKAFLERYPDYQLNGYGRWAVISKETDVFIGWCGLKFGEIPNETDIGFRFFEEEWNKGYATESAAACIRYGFEQLNLRRIVGRAMKANTASIKVLEKIGLVHERDVIFDGMEGVIYRIEEEQDPGDGLITKPYVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S9</accession>
    <name>C6X5S9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NorM-like multidrug efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01319"/>
    <dbReference type="EnsemblBacteria" id="ACU07767">
        <property type="protein sequence ID" value="ACU07767"/>
        <property type="gene ID" value="FIC_01319"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01319"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_6_3_10"/>
    <dbReference type="OMA" id="TGNQKVG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="466" mass="51164" checksum="0DD0D2660F30B329" modified="2009-09-22" version="1">MQYFCCKFFCIMAFLNKEYTKACLTLALPVMITQVGQVSVNLFDNIIVGKLLGAQALASVSLGNAVFFSMFVFALGFSFAIPPLVSEAHSQEKHSVINSVFRHGFVINIGVGLALMLLLFLAMPILYHMDQPPEIIPDTVGFLSIMTLSILPFMAFQTLREVSEGLSYTIGVTKATIIANVINIVLNYVFIKGMFGFPAMGVEGSALASLIARIFMVVFLYYVLIKEKSTRRYVKDFSLKIAGFSKEMFRKMLKIGFPTALQMFFEVTAFAGAAFICGLVSAHDIASHQIALSMASFTFNLCIGFSVASTVLIGRKLGEGDYVGLQKVGVNNLKIVFLFMLFCGLVFIVGRHVLPTFFTRKEDVDVIQLAAKLLIIAALFQLSDGIQVVALGCLRGIQDVKIPSIITFVAYWLIAIPLGYFLCVPFKMGAFGMWIGLGLGLTVSALLLVRRFLKLSQNKINSLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5V9</accession>
    <name>C6X5V9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01349"/>
    <dbReference type="EnsemblBacteria" id="ACU07797">
        <property type="protein sequence ID" value="ACU07797"/>
        <property type="gene ID" value="FIC_01349"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01349"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_5_0_10"/>
    <dbReference type="OMA" id="GIYAKFN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970717" description="Peptidylprolyl isomerase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="281"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="374" mass="40638" checksum="142E2A8993C4556A" modified="2009-09-22" version="1">MIKKNLLIAIAAISLSSCAPIYKKMNVEKETYEGLKDGLYANFQTSQGNMIVKFEDKKSPVTVANFVGLAEGKIENKAKAKGVPFYDGTIFHRVIKDFMIQGGDPQGTGMGDPGYKFDDEKNDLQHTGKGILSMANSGPNTNGSQFFITEIATPWLDGKHTVFGEVVNGEEVIDAIANVEKGPQDKPKTNIVLEKVSVFSKGDEYKGYDAAKIFAEGKSKIQENNKAIIAKIEADKKKKEEEFAANQQKLVDDMKAGMQVTASGLYYKITKTTAGVAPAKGDDVAVHYAGRLVDGTEFDSSFKRNEPIEFPVGIGQVIRGWDEGILLLKEGEAATFLIPSDLGYGPRGAGGVIPPNAWLIFDVELVKVNAKLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W0</accession>
    <name>C6X5W0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806083.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01350"/>
    <dbReference type="EnsemblBacteria" id="ACU07798">
        <property type="protein sequence ID" value="ACU07798"/>
        <property type="gene ID" value="FIC_01350"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01350"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110184_0_0_10"/>
    <dbReference type="OMA" id="TYYVDKQ"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="86"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="169" mass="19506" checksum="1B79614183B74053" modified="2009-09-22" version="1">MKKILFISSVLLIGCAQNSQTHPPVGGFLSEKDLEASKNRARYLNETERLQIEDWIKQQPEKYYPMSLNYWVNIENLQQNQRKTEGETVSYEYEIFDFDQVKLSSAPIRKTDVQFGKFEELKAVEDVLRYLDKGQSATLLVPSVIAFGTYGDNDKIPNDLPLIIRIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Y9</accession>
    <name>C6X5Y9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806112.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01379"/>
    <dbReference type="EnsemblBacteria" id="ACU07827">
        <property type="protein sequence ID" value="ACU07827"/>
        <property type="gene ID" value="FIC_01379"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01379"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_10"/>
    <dbReference type="OMA" id="IILTMFE"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="218" mass="25126" checksum="0E7EB41BEE22F7B0" modified="2009-09-22" version="1">MRNEIILYDNHYLSMEAFCCFLDSNGYSKTYDYRFTSDYNELVELVSDRASIAIINICGIPVNDAVELPDKLLAINPNLKIIILSSNPDVKIIKKFFEKGVKSFLTKTADSKEFVFALKEVLAGKVYLTEDTKTALYNFICNVEQIEEHDPSRLEELTVREKEVLHHICEGLRTREIADELFISPHTVESHRRNIMQKLDVRSSSMLVKFAMNNNLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X625</accession>
    <name>C6X625_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01415"/>
    <dbReference type="EnsemblBacteria" id="ACU07863">
        <property type="protein sequence ID" value="ACU07863"/>
        <property type="gene ID" value="FIC_01415"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01415"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105789_1_0_10"/>
    <dbReference type="OMA" id="GWTIRQV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01256">
        <property type="entry name" value="YfiT_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023774">
        <property type="entry name" value="Put_metal_dep_hydrolase_YfiT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DinB_2" evidence="5">
        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="180" mass="21427" checksum="408DFAC6D7212B4D" modified="2009-09-22" version="1">MMDSLEHKKYPIGKFEYAGEITDQHIDQYIGTIKNFPTKLKDAIRNFSDDMLDTQYRMDGWTVRQLVSHLADSHMQSFSRFKLALTEDNPTIKPYDEAKWAELQDCRNEPVKASLMILDGLHCRWTHLLKTMTNKDFERTFFHPEHNKKIYLRDNVAFYAWHCRHHLAHIESLIKEKGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X627</accession>
    <name>C6X627_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TSPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806150.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01417"/>
    <dbReference type="EnsemblBacteria" id="ACU07865">
        <property type="protein sequence ID" value="ACU07865"/>
        <property type="gene ID" value="FIC_01417"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01417"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032380_0_0_10"/>
    <dbReference type="OMA" id="LYWYISK"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSPc" evidence="1">
        <location>
            <begin position="243"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="512" mass="59176" checksum="86A902F1D3414EE7" modified="2009-09-22" version="1">MRFFLLLLFALLTSCVSVKKHNQKLEQLIPPEKLRNDVDFAREKLQKLHPNIYWYISEVDFNHKFDSLKTSISKPLKPNEFYRKLAPVIAQVKEGHLRLLPMGKRLTRAEIKHLKNQKGLLNRYNFTLDGNRIFVKDNADKIPNMDVGSEILKINDVPAADMLQKYRPFINSDGENKTFQKYILALRWPAYFTAEYGILDSIKLETKYRNELKTFYLKREKISKEEKKTEEIRNKKLTKSEQGKTKHYNLITKSFNRDLQFLTKDSSVAYMKIRTFSGTFSKKFYRESFAALKKSPAEYLVLDVRDNLGGSLSEINNLYSYLVSDEFRFINDIEITSRGAMFKADYFSGFPLLTKPIAVLAYPFYLLGTALSVKKDNDRFLLKNNGIFALKKPKKDNFEGQVYVLINGSSFSAAAVLPSKLKDDKRAFLVGEETGGANDGTVAGRYSFERLPNSRLYLPIGLMLIQPNIEFTHTKKGVVPHQEILRTTQQIIDKSDAELDWVMNDIKNQQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X665</accession>
    <name>C6X665_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recG</name>
        <name evidence="9" type="ordered locus">FIC_01455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01455"/>
    <dbReference type="EnsemblBacteria" id="ACU07903">
        <property type="protein sequence ID" value="ACU07903"/>
        <property type="gene ID" value="FIC_01455"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01455"/>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_10"/>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="282"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="477"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="696" mass="79605" checksum="153BC3CBC216D83E" modified="2009-09-22" version="1">MNLDTPIEFLKGIGPERAKFIKNVLGIAMVEDFLTFYPIRYIDKSKLYFINDLKEEPEAEIQLKGKITDLQEMGYGNGKKRLSAKFRDETGTLELVWFRYSKWMKDQLPLNTDIFIFGKVNLFNGTFSMAHPEIEINEKKALSGSLLPIYPGSEKLSKRGINNKFFQVVLAEITRNLPALIQENLPDALMKKLKLISRIHAFYHIHFPKDFNHFEHANRRIKFEEAFFFQLGYGLKKQHHKTSVVGNPFSKIGKNFKGFYEHSMPFELTNAQKRVLKEIRTDMKKPVQMNRLLQGDVGSGKTMVALLAMLIAMDNGFQSCLMAPTEILAQQHFNSIKELTEKTDIKIRLLTGSTKTSDRKIIHEELLSGELTILVGTHAVLEDIVRFRNLGLAIIDEQHRFGVAQRARLWAKNKIAPHILVMTATPIPRTLAMSFYSDLDVSVIDEMPVGRKPIITAHRREKDRLSVFRFAKDEIEKGRQVYFVYPLIEESETLDYKNLLENYDHIVEFFEGKNATMLHGRMKPAEKEAAMKYFASGKAEIMVATTVIEVGVNVPNASVMIIESAERFGLSQLHQLRGRVGRGGEQSYCILMTSDKLTKESRTRVKTMTETNDGFKISEVDMQLRGPGDILGTQQSGVVDFKKLDLVADGTIIQVAKKTVEVLLKHDPHLQSDENRSLKNYYVKQYKGKNKWSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X673</accession>
    <name>C6X673_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ordered locus">FIC_01463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806196.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01463"/>
    <dbReference type="EnsemblBacteria" id="ACU07911">
        <property type="protein sequence ID" value="ACU07911"/>
        <property type="gene ID" value="FIC_01463"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01463"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_10"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="253" mass="28062" checksum="8A65A19BCEF05D74" modified="2009-09-22" version="1">MRKNIVAGNWKMNKNVIEAQQLMFQLLEYKKNNSTNCEVWIAPPSLYLMMAKDLYEQDEIGVFAQDMSEYESGAYTGEISADMLESIDATGAIIGHSERRQYHGETDSHCNRKVKLALDKGLIPIYCNGETLEQRKSGQHLEVVKNQTETALFTLTADEIKKVVIAYEPVWAIGTGETASPELAQEIHAHIRKLITDKYGKEVADEISILYGGSVKPDNAKEIFSQPDIDGGLIGGAALKVDDFAKIIEGFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E8</accession>
    <name>C6X6E8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP pyrophosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
            <ecNumber evidence="3">3.1.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
    <dbReference type="EC" id="3.1.7.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806271.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01539"/>
    <dbReference type="EnsemblBacteria" id="ACU07986">
        <property type="protein sequence ID" value="ACU07986"/>
        <property type="gene ID" value="FIC_01539"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01539"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_2_10"/>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="404"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="734" mass="84782" checksum="D354388B857C06E2" modified="2009-09-22" version="1">MVYDIEQENKEILARYKDLISNTYRTLDEEHNKLIRKAFDIALDAHKDQRRKTGEPYIYHPIEVAKIVANEIGLGATSIACALLHDVVEDSDYTYEDLKKLFGEKIADIVNGLTKISVMNHQNISIQSENYRKLLLTLSEDFRVILIKIADRLHNMRTLESMTPDKQKKIASETVYIYAPLAHRLGLYNIKSELEDLSLKFNNPDVYFDISERLELAKESREKYIEEFKTEVSEQLETEGLKCSIKGRAKAISSIYRKMLKQGVTFEEVFDNYAIRIIYRSDAKNEKFLAWKIYSIVTDLYHSNPQRMRDWISQPRSTGYESLHLTVLGPDKKWIEVQIRSERMDDIAEKGVAAHYKYKEGFRQSSDEKNFENWVTEIREVLENQQALTTTELLDNIKLNLYSKEVFVFTPKGEIKILPIGSTALDFAFSVHSDLGTKCLGAKVNGKLVPISYVLQNGDQVDILSSQNQKPKADWLDFVITSKAKSKIKAILNSEKNHLSEEGKEILQRKMRHAKINFNDEEINKMQKFFNLKTSQELFLNFQNGSLDISDIKKYTEGKGIFSNIMQRFRKSPNKNEVYTELPDTNLDMIVFGKDEEKMNYSFSKCCTVIPGDKIFGFITISEGIKVHNDACPNAINLRAQYDYRVLPAKWVNEESFKNRIKIEIEGLDRMGMINDITAVISNSMNMDMKSMSIESNNGIFLGNINLEVRNKSQLEETFKQLKNINGVSRVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F6</accession>
    <name>C6X6F6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock protein, DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01547"/>
    <dbReference type="EnsemblBacteria" id="ACU07994">
        <property type="protein sequence ID" value="ACU07994"/>
        <property type="gene ID" value="FIC_01547"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01547"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128058_1_0_10"/>
    <dbReference type="OMA" id="TEKYFFH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="104" mass="11562" checksum="F15AAA9FEAA9A8B8" modified="2009-09-22" version="1">MFLYVDANGQLTETRPEDQNREGVNLDDIQLGAAPIEAEELVKTGIVTFLSDKGYGFITEAGSQENVFFHENNCAHQVKKGNKVSFEKERSPKGFSAINIQIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC0</accession>
    <name>C6WZC0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanosine(18)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA [Gm18] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmH</name>
        <name evidence="4" type="ordered locus">FIC_00496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00496"/>
    <dbReference type="EnsemblBacteria" id="ACU06954">
        <property type="protein sequence ID" value="ACU06954"/>
        <property type="gene ID" value="FIC_00496"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00496"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_4_1_10"/>
    <dbReference type="OMA" id="KIPMVGF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009020">
        <property type="term" value="F:tRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052665">
        <property type="term" value="F:tRNA (uracil-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002938">
        <property type="term" value="P:tRNA guanine ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18092">
        <property type="entry name" value="SpoU-like_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02060">
        <property type="entry name" value="tRNA_methyltr_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033671">
        <property type="entry name" value="TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453">
        <property type="entry name" value="PTHR43453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="255" mass="29064" checksum="0DA2AD7BC67C693D" modified="2009-09-22" version="1">MLFGARFARATSAVISERQALTALAPPNKKHYFCPMNDQQTFDYLKQFLTDERLAKIEHYAPESSGFVLPVMEDIFQFRNAAAIVRSVEACGFHKIVAMESENEFNPNLRVTKGAETWVEVEKMPHNLESLTEIKNRGYKILAVSPEKNATMLPDYQLKEPVALVFGTEKEGVTEEILDFADETVAIPMYGFTRSFNVSVAAAICFYELKQKLIRSNIDYKLSEEKLWEIKVRWAKNSIASGEQILAKYRSDQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZE8</accession>
    <name>C6WZE8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781630.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00005"/>
    <dbReference type="EnsemblBacteria" id="ACU06483">
        <property type="protein sequence ID" value="ACU06483"/>
        <property type="gene ID" value="FIC_00005"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00005"/>
    <dbReference type="eggNOG" id="COG4270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128738_4_2_10"/>
    <dbReference type="OrthoDB" id="1606159at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="119" mass="13648" checksum="DBE8FD0CAD55A779" modified="2009-09-22" version="1">MDYLDISKYLLATLLIIAGILHFIQPKFFERIVPKYLPAAKLLVLLSGIAEVICGVLLITHQTQSIGAYLTIALLIAVFPANIEMARLYYVKKKKGFWITVLRLPLQILLIWWAFKFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF4</accession>
    <name>C6WZF4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ordered locus">FIC_00011</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00011"/>
    <dbReference type="EnsemblBacteria" id="ACU06489">
        <property type="protein sequence ID" value="ACU06489"/>
        <property type="gene ID" value="FIC_00011"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00011"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_2_2_10"/>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="141"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="280"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="154"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACU06489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="383" mass="44148" checksum="EB6911B47004A54E" modified="2009-09-22" version="1">MTEIHDQNLGDAFVVSTCNRTEIYTTSQNYLLIAELYCKTIGVSLSEFMLYVNILKHEEALNHLFRVAAGLESQIIGDFEIIGQIKNAYHRFKKVKRNANPFLERAINSAIQISKRIKNETGISTGAASVSYAAVHYILKNQPHLSDKNILLLGVGEIGQNTVENLVKHVYKPRVKVVNRTADKAEKIAEKYKIPHIEYDQFNKELSQTDILIVATGAQHPIINKTHFPNGKETLVIDLSIPNNVEKNITENTNVRLVDVDDLSLQINETMVSRQKEIPKAEAIIKEMTKDFLEWEKKRKLAPNIHHFKAVLKNMERNEMHNIHKKHKYVDVHDMQLSDKMIQKITNRFAKYIIDNPWKADEVSRLMHEILVEQPNNEFNEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ8</accession>
    <name>C6WZJ8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781680.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00057"/>
    <dbReference type="EnsemblBacteria" id="ACU06533">
        <property type="protein sequence ID" value="ACU06533"/>
        <property type="gene ID" value="FIC_00057"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00057"/>
    <dbReference type="HOGENOM" id="CLU_2395384_0_0_10"/>
    <dbReference type="OrthoDB" id="2065525at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="93" mass="9250" checksum="3DE5AAF73C02420C" modified="2009-09-22" version="1">MKKTLFVGIAVIAFAVTSCKKSENTETMSSDSAMTGTTDSMMMNTDSAMTPNADSINTTVMPDATGTGTTGTTGTGTTGTTGTSGTTGTDSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZL1</accession>
    <name>C6WZL1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781693.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00070"/>
    <dbReference type="EnsemblBacteria" id="ACU06546">
        <property type="protein sequence ID" value="ACU06546"/>
        <property type="gene ID" value="FIC_00070"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00070"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_1_4_10"/>
    <dbReference type="OMA" id="CTHRLEE"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041474">
        <property type="entry name" value="NicS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17938">
        <property type="entry name" value="TetR_C_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="208" mass="24144" checksum="137E5CA93091EB88" modified="2009-09-22" version="1">MKKKFSDKQIHILDVAEKLIAKKGFEGTSIRDISSQANINVAMISYYFGSKEKMMSYLYRYRVQKTREHFAEFAEIIKDGKPEMQMKELIKHVVSQLFKYNYFHGFVTQELRHTEHLKDDLLEFYTTFTAKLEDVVKKGVVTGVFTNAPKAEDILTIIIGSALFVIRNKNFYELYVAGKEENYLKDAEEKVLANLLVTVFSLLGYHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ3</accession>
    <name>C6WZQ3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_pol_B_exo2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781735.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00113"/>
    <dbReference type="EnsemblBacteria" id="ACU06588">
        <property type="protein sequence ID" value="ACU06588"/>
        <property type="gene ID" value="FIC_00113"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00113"/>
    <dbReference type="eggNOG" id="COG3298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188834_0_0_10"/>
    <dbReference type="OMA" id="AHNGKEF"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019288">
        <property type="entry name" value="3'-5'_exonuclease_PolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10108">
        <property type="entry name" value="DNA_pol_B_exo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol_B_exo2" evidence="1">
        <location>
            <begin position="62"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="231" mass="27080" checksum="3C0171003908AE35" modified="2009-09-22" version="1">MLQHVPLEKVLFLDIETVPQHGNWDGLGESGQYLWDKKTKMQRKDDYTAEAFYAERGGIMAEFGKIICISVGILDKSEKLMIKSFYGDDERKLLEEFGEIFNRPKLREVILCAHNGKEFDFPWIARRFLINGLQPPKPFQMFGKKPWEIPHLDTMELWKFGDYKSYISLELLAHVFGIPTPKDDIDGSMVASIYYIEKDLFRIVQYCEKDVLTLANIFRRMRQEGLLEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ7</accession>
    <name>C6WZQ7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAO/AO transport system ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00117"/>
    <dbReference type="EnsemblBacteria" id="ACU06592">
        <property type="protein sequence ID" value="ACU06592"/>
        <property type="gene ID" value="FIC_00117"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00117"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_2_2_10"/>
    <dbReference type="OMA" id="WMWERID"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="328" mass="36420" checksum="FEDA77223D5F5A92" modified="2009-09-22" version="1">MIMDFSVQQVTEGIRKGDKRILGKAITLVESKKPEHRALAEELLRNILPFTGNSVRVGITGTPGAGKSTFIENFGKLLVNKGKKVAVLAIDPSSAINKGSILGDKTRMEELSKEENAFIRPSPSSGFLGGVANATFETMLICEAADYDYILIETVGVGQSEVLVADITDVFLFLKIVGGGDELQGIKRGIMEMVDIVFINKVDPQNRTKAKSTKTELMRALHFMSPKEKNWKVPVLLGSALNNEGLNEVFGKLEDFITLKTQSGSFTETRKRQAEKRFDYWVQNYILQMMSQENHTGNLYESHKKNASELRANPSTEAKLFVDQLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZQ9</accession>
    <name>C6WZQ9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent protease with chaperone function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781741.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00119"/>
    <dbReference type="EnsemblBacteria" id="ACU06594">
        <property type="protein sequence ID" value="ACU06594"/>
        <property type="gene ID" value="FIC_00119"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00119"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_5_0_10"/>
    <dbReference type="OMA" id="QWEVNLI"/>
    <dbReference type="OrthoDB" id="1530824at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="86"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="268" mass="29060" checksum="15B819B51A7FAFFE" modified="2009-09-22" version="1">MKNVNKLVGTGVLAAMMVACTTNPITGRKSLQLANDQEITAMALQQYRQTLAAAKVVSGTTAANSVKNVGTRIKNAANNYYRGIGRETDMSNYQWEFNLIDDKQVNAWCMPGGKVAVYTGILPITKNDTGLAVVMGHEISHALAGHGNERISQAMVAQYGGAVLGSATSGQMASIFQQVYPIGAQVALLKYGRGQELEADEMGLYLMAMAGYDPRQAQPFWERMESASSGNRPPEFLSTHPSPESRRSDLEKRMPKALEYYKTAGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZT4</accession>
    <name>C6WZT4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase subunit CcoP</fullName>
            <ecNumber evidence="8">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781766.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00144"/>
    <dbReference type="EnsemblBacteria" id="ACU06619">
        <property type="protein sequence ID" value="ACU06619"/>
        <property type="gene ID" value="FIC_00144"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00144"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061347_1_0_10"/>
    <dbReference type="OMA" id="ILDHNYD"/>
    <dbReference type="OrthoDB" id="1315115at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032858">
        <property type="entry name" value="CcoP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038414">
        <property type="entry name" value="CcoP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14715">
        <property type="entry name" value="FixP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="183"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="292" mass="32745" checksum="5A6AC582E39D0E69" modified="2009-09-22" version="1">MKQRTPVYITILIIVALIMVVCYMFIQSSAFFLSPYFWGTVIIAAIIAMIQHSIGDLVENTKFKTLTEEEKLAYIESKKVPYYKALYDSAFKKQSATEEKDILIDHGFDGIMELDNQLPKWWLGLFYFGVAYCVVYLLAYSFTDFAHPLPEYEEEYQAQIVSIDEYMKNTPPPTIENAAYSPDNIAAGEEVFKTNCVSCHGDGGKGGIGPNLTDNNWINQPEKTLFKNVFHMVENGSQNNPTMQAFGKNNVLSGFDIQNVAAYVYHINQEQPPVTPAAGGAAPQGDPAVWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X013</accession>
    <name>C6X013_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="6" type="ordered locus">FIC_00224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781845.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00224"/>
    <dbReference type="EnsemblBacteria" id="ACU06698">
        <property type="protein sequence ID" value="ACU06698"/>
        <property type="gene ID" value="FIC_00224"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00224"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_1_2_10"/>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="OrthoDB" id="1669228at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU06698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="143" mass="15694" checksum="9A57BAA504033E9A" modified="2009-09-22" version="1">MKIKVINRSRHPLPKYQTELSAGMDLYANIEEEISLASLERKLIPTGLFLELPAGFEAQVRPRSGLAIKNGITVLNAPGTIDADYRGEIGVILINLSKDTFTVKDGDRIAQMVIARHETATWEETVELQVTQRGAGGFGSTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X023</accession>
    <name>C6X023_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00234"/>
    <dbReference type="EnsemblBacteria" id="ACU06708">
        <property type="protein sequence ID" value="ACU06708"/>
        <property type="gene ID" value="FIC_00234"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00234"/>
    <dbReference type="eggNOG" id="ENOG5033ZC6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456902_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="597" mass="69912" checksum="09B7C95BB515052F" modified="2009-09-22" version="1">MPKFETLAKLSPATRCTPISPTKVLKYRCPNLIPLRYFTRPQNILSRTSRLPLFHQPPNTVIMKAHLNTISRQNLPPKVKQQLNLLIMENDAELIFFSREHLCSLPTLTVIIGKNTDSRQLQELQQHDWVRNSIEKPGLIIAVNAHSSHAPEPDLHFSYIVLNCHPRHLIYARTEKSWNSRFQNDYSLKQSRNEKQFRAWQSGIENQCAAYYSQFIAPNSDTRSEDVLQAGLKAVYEELLSGFRKIFLPKNLHSFYKGAAVLDFMQQHVPELKQPLAQIEGHAIKRILDRSTTVMNETQRQEHLDYVQILRGIFSTNLAHLFYGKFRQTLSWNQYAEVYLQKPVAAEKPERDLPAAIAEIIKQQYKTQYIYWVPQKASEGQPRRYLLIMLGSSLKITQLHFVQQLMATHFPELQICILLHKTDWIKKHYGLFYGFIDRYLSSEYLIDRSQKELSFPAKVEQERDGLVRRYWAERKEIIDVQWTSVGFPESEFTEGQVLYLRSIFQQLFLGTLYHYAHYLPNTLNLNYLWELITWFAPELPQKIRMNRPMQEVLAFIGTPVHNFPNIDEPEVDISTISFQEAVSCCSRLYEHLNNELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X050</accession>
    <name>C6X050_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781882.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00262"/>
    <dbReference type="EnsemblBacteria" id="ACU06735">
        <property type="protein sequence ID" value="ACU06735"/>
        <property type="gene ID" value="FIC_00262"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00262"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026364_0_0_10"/>
    <dbReference type="OMA" id="EGYDWAN"/>
    <dbReference type="OrthoDB" id="305021at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972161" evidence="1">
        <location>
            <begin position="19"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3857" evidence="3">
        <location>
            <begin position="60"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="292"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="641" mass="73553" checksum="E8EDC615D7AD2B18" modified="2009-09-22" version="1">MKKTLLAFSLLVTGFIFAQHKFLDVPALSDEDLKSDKSAKFGDVPAEIIYRSVHFRVDYDGQMYQNVVSRIKIYNKDNASDYLDREISLYDNNNGSRETLSALKAFTYNYENGKSVATKVSKDEKYKSREDKNYNITKFAFPNVKNGSVIEYSYTILTPFLSSTPRILIEDDIPSRYVEFVLDVPKPLGYNINYKGELHPQHRLVQEKQLYGNLYQTYRFAYENVEGYKEEQYVMNNNNYKTGIKAELNSTMINNVFKSYATSWEDIRKRLYEHGDFGGQLSKESMVKNLMPAQTKDLPLISRADAILKYVQDTYTWNDEDDVVTDKGVRNLISTKVGNSAEINLLLTMLLRNAGIDADPVVLSTVSRGALLAYLPSIAQLNYVVASFADQGRIYLLDGAQKYSEINMIAPKALNYYGLVMGKKDVKQINMFYPEVSKTFLTVDAKLNPDGTFEGQFADRDTKLYAMVVNERYTDDKDKFAKSYKDQYRFSLANMKHGMQQNKDFETSFDFTSDTFSDAIGNKIVFNPLLFLYAQNHDFKQPGARKAPLEFYSPNDKIKKVTITLPDNYVFENVPKSKKFRTDDNALQYTYLVTQTGNQLTVETITQIDDSVFPKEYYPAFTQIFDNITKMEAQVVTAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X052</accession>
    <name>C6X052_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_00264</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00264"/>
    <dbReference type="EnsemblBacteria" id="ACU06737">
        <property type="protein sequence ID" value="ACU06737"/>
        <property type="gene ID" value="FIC_00264"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00264"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010638_0_0_10"/>
    <dbReference type="OMA" id="KQSIYRW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="496"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU06737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1064" mass="122896" checksum="B1CF26009928D54C" modified="2009-09-22" version="1">MLLLKSIYNSMVQKNYRVINASAGSGKTYALVQNLLVICLKHPSQPDKIRNILALTFTNKAANEMKQRIIKWLREFSSAEYANNQDLKNIQQKMKVQGIELSLETLHKRSRKILDYVLHNYSTLNIGTIDKFNSRLVRSFSYELGLAQNFNLEINAEPYLVEAVEKMLADIGAENDVSDAFMDFVNYSLDNNERVNLNKTLYDSAKEFVQDKHYFRLSQNKEFDWKVYGEAKQRLRDNIKSLKEDSLKITETCINLLNEKNLEIADFSGGSKNSIAKFIIEAARFYKKERADFPFPSNEETALTNFQSGASSKSKNRQSEILEILDFLIESRSKIIKNYIETQREEKILHALLPLKVNKDIQDKLAEIEEKNDVVLLSKFNILIHENLREEPSSFIYEKVGTQFSHYFFDEFQDTSFLQWQNFIPLRDHAVSSDEMSFTLVGDPKQSIYRFRGGDSQLMLDIINKQEKSLVLADLENLGDNWRSAKNIVDFNNQLYQFLSAHTQEAHCDIFGKGSQQTPKSESSGRVRINLIENSTKAIYYEDVAEKMCEDLQACVDNGFRFADITILCRGNFDIFSFSNLLGNLKINYNGKEEFIKTISESGLTLNLSSTLLALTEFLRWEQNPKNFQFPVKMLYYLNILGRITIEDFSADMMEMLAFKTKPEIQDFIENRYGIRLRNETLLQLNLYNFVEHFLQEFSVAGKETDFLFNYLEMLYAFSQNAGANLKDFLRFWDEEAQEATIQASDNLDAVKLMTIHKAKGLEFPVVFLPMANSHKDGKFSNWLDIKDHAGLAAVNVPSFGKELEVYDEDMAKFNQENNYQNKIDRFCLQYVATTRAAEQIFLYIEKPNKTTNNLEIYEFLEPNIPLNEHLEPLSSFDLYEVSPEILKKKESDKAETAVTQAVRFKNEKVPNPAAIQIATPSKSYQNRVEKVRTGIFTHEILAKINSKDDVEKTLENYLLDGIITQTEKQYISERLLTIINDGRYAQYFAPNQRVINEKDIMISAGGESKIYRPDRLIDTGDGYIIIDFKTGGVKEKHQQQVDEYQSVLEKLGMKVRETAIVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X058</accession>
    <name>C6X058_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="9" type="ordered locus">FIC_00275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781890.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00275"/>
    <dbReference type="EnsemblBacteria" id="ACU06743">
        <property type="protein sequence ID" value="ACU06743"/>
        <property type="gene ID" value="FIC_00275"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00275"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_0_10"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="180" mass="20431" checksum="B0DE10DD316A805B" modified="2009-09-22" version="1">MSDLKWYVLKSISGQENKVKTYIENEMKHHGFEAFVTQVVIPMEKVIQLKNGKKVPKEKPYYPGYLMVEANLVGEIPHIIKNIPGVISFLSLTKGGDPVPMRKSEVNRMLGRMDELSEFAVETSIPFVVGENVKVIDGPFNGFNGTIEKLHEDKKKVEVSVMIFGRKTPMELSYMQVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X083</accession>
    <name>C6X083_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hexapeptide transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781915.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00301"/>
    <dbReference type="EnsemblBacteria" id="ACU06768">
        <property type="protein sequence ID" value="ACU06768"/>
        <property type="gene ID" value="FIC_00301"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00301"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_7_1_10"/>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="OrthoDB" id="1242595at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="171" mass="18342" checksum="1D0160875C22000D" modified="2009-09-22" version="1">MAIIRTLLGKTPQIGAGSFLAETATVIGDVTMGDNCSIWYNAVIRGDVNFIKIGSKVNVQDNVMLHCTFEKFPLIIGDNVSIGHNAIVHGCTIKDNVLIGMGAIVMDDCTVESNSIVGAGSVVTQGTHIKSGEVWGGIPARKIKDISSELLEGEVNRIANNYVKYSGWYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X095</accession>
    <name>C6X095_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00313"/>
    <dbReference type="EnsemblBacteria" id="ACU06780">
        <property type="protein sequence ID" value="ACU06780"/>
        <property type="gene ID" value="FIC_00313"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00313"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868041_0_0_10"/>
    <dbReference type="OMA" id="NSARIID"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="320" mass="35707" checksum="3269E8B52FCE46A9" modified="2009-09-22" version="1">MIHIMRKLGALLFIFIFINQYKSQETLPFYQQYLMEGDLLFNPAQYGKTDDVVLNLNYQKQFSNFDQSPNVQSIALHANVFDRVGAGLTFFRDQNGPVSSNGITGGGSYFIPIDDDGERLSQFSFGTSVSLYNMNIDLAMLNPEDPGDPTLSEDNNSIFLAYANFGMAVTYRNFFAGVSINDIAITNDIPIVNGIEPEPTKYIFNAGYDYYLTEGFYVSPSVMMNLNTNSARIIDMNLLATVGDEYNSFSGGVSFRTAKNKFGSQNLGISPIIKATVNDFFFGATYNFGLSDIQQYAGSSFMLSVGYNLENFINTRGFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X098</accession>
    <name>C6X098_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781930.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00316"/>
    <dbReference type="EnsemblBacteria" id="ACU06783">
        <property type="protein sequence ID" value="ACU06783"/>
        <property type="gene ID" value="FIC_00316"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00316"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_10"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="196" mass="22291" checksum="0107AF2B4AF8BDE2" modified="2009-09-22" version="1">MYRIISGRWKSKRISAPKNFDVRPTTDFAKEALFSIIENRFNIDVSAGSVLDLFAGIGSVSLEFASRGCQDVTSIEMNARHAGFISSTAVELEMAPQVNVQRGDVYEYLKKNRNRKSYDIVMADPPFDTDQPKYDELISLVLNNPYLKPGGLFILEHQSRMKVEHPNLLDTRKYGNVSFSFFKPNTPEETEEPTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A0</accession>
    <name>C6X0A0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00318"/>
    <dbReference type="EnsemblBacteria" id="ACU06785">
        <property type="protein sequence ID" value="ACU06785"/>
        <property type="gene ID" value="FIC_00318"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00318"/>
    <dbReference type="eggNOG" id="ENOG5032S06">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167494_0_0_10"/>
    <dbReference type="OMA" id="CDLAVRI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045950">
        <property type="entry name" value="DUF6370"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19897">
        <property type="entry name" value="DUF6370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="82" mass="8879" checksum="DBB486A2CAED306E" modified="2009-09-22" version="1">MHVVEASCGQCQFKMKDKKGCDLAVRLDGKAYFVDGTDIDDHGDAHSSAGFCNAIRKAEVTGKIKEGKFVATSFKLLPDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0A5</accession>
    <name>C6X0A5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06790">
        <property type="protein sequence ID" value="ACU06790"/>
        <property type="gene ID" value="FIC_00323"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00323"/>
    <dbReference type="HOGENOM" id="CLU_2972805_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="58" mass="7120" checksum="13D2CC33D152C6C1" modified="2009-09-22" version="1">MMQKNEKIKTWIFFDHFILFFWLKPKEPKVQDLDLFAKKLKFLKKTSKLGRTARLFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0D3</accession>
    <name>C6X0D3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid carrier: UDP-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781965.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00351"/>
    <dbReference type="EnsemblBacteria" id="ACU06818">
        <property type="protein sequence ID" value="ACU06818"/>
        <property type="gene ID" value="FIC_00351"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00351"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_4_10"/>
    <dbReference type="OMA" id="QVQNIDM"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="202" mass="23084" checksum="A699EE2FAC1DD353" modified="2009-09-22" version="1">MYKLFWKRLIDFTAALVGLIILSPVFLLITLCLAIANSGKPFFFQKRPGIKEKIFSIIKFKTMNDRRDSKGDLLSDYKRLTRIGSFVRKTSLDEIPQLINVLKGEMSLIGPRPLLPEYLPLYTSIQKRRHEVRPGITGWAQVNGRNAISWEDKFTFDVWYVDNLSLSLDLKILLMTVKKVFKSEGINAAGQATTEHFKGSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F2</accession>
    <name>C6X0F2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound O-acyl transferase, MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_00371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781985.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00371"/>
    <dbReference type="EnsemblBacteria" id="ACU06838">
        <property type="protein sequence ID" value="ACU06838"/>
        <property type="gene ID" value="FIC_00371"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00371"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_1_3_10"/>
    <dbReference type="OMA" id="IIWGAWH"/>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU06838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="476" mass="55733" checksum="7A37A1AB6A3176A6" modified="2009-09-22" version="1">MIFNSFAYLFFLPVVFILYWFFTRKSIKLQNILLLLSSYVFYATWNWKFLFLLIFSTLLDYYTGIKMSKAKNRMSKKFWFWLSIGVNLGFLGVFKYYNFFITSFAEALDKIGFQANLSTLQIILPVGISFYTFHGLSYVIDIYRDKIEPERNFLDYAVFVCFFPLLVAGPIERATHLLPQIQTKRTFDYSKAVDGLRQILWGLFMKIVVADNCAPVVNEVFSNQSSYNAPSLIIGAVFFAFQIYGDFAGYSNIALGSAKLFGIDLLKNFSFPYFSRDIAEFWRRWHISLSSWFKDYLYIPLGGSKGGKWMQIRNTLIIFVVSGFWHGANWTFIIWGFLNALYIMPLVVFNLNRKNTDTVAENRLLPSFKESSQIIFTFIITTIAWVFFRSETVNGACDYLGRIFNVHNYAYPQTALRPFVFIFLLIVVEWLQRKRQHGLELDHCRNVVIRWFIYAVLLLIILVFGANSDSFIYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0H1</accession>
    <name>C6X0H1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VcbS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782004.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00390"/>
    <dbReference type="EnsemblBacteria" id="ACU06857">
        <property type="protein sequence ID" value="ACU06857"/>
        <property type="gene ID" value="FIC_00390"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00390"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596834_0_0_10"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970510" evidence="1">
        <location>
            <begin position="21"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="458" mass="50635" checksum="297396EC6D033E59" modified="2009-09-22" version="1">MIKKLLFSCLLAAAAVPSAAQSLDATFGNGGTRIYNDLGSFYDAEVAADGKIILPGNYYANDVSALLVRFNTDGTLDTGFSGDGKYEINQFSDPNYYEEFYNARVLPDGKLLVMYYYEFDNGTTDFSSSKLMRFNANGTVDNTFNSPATTGGNYYESFEVLPNGKILAVGNNALHRLMPNGALDTSYGTNGVRPLNFEFWQIYVTPQGIFFQDYVENRMVKMPNEDSSVFTYYDVNSSFNYKLKHGFLYLQVYDGQEKIIKLDQTLQPVASFGSAGVFTVPVGMYFVLSEVQENGSILSVTRTYNPGTGNTAVDIVRINPNGTLDLTFGNQGTFTQNYDGEYWSYSFYHPTQKKLYVWNEIDNSMDMLVSRFNLPQEQLAVADSAAKTTVRVLQNPVSDILKLSAKLDNAQVYSAAGGKTAVEFSGDQVSVANLRTGLYLVSGKDAQGNTVTLKFVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Q1</accession>
    <name>C6X0Q1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782084.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00475"/>
    <dbReference type="EnsemblBacteria" id="ACU06937">
        <property type="protein sequence ID" value="ACU06937"/>
        <property type="gene ID" value="FIC_00475"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00475"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_0_1_10"/>
    <dbReference type="OMA" id="QGTPYFN"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="39"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="315" mass="35250" checksum="CAFF337EE7BCAA54" modified="2009-09-22" version="1">MDRKKFLKTIGGGSLALTLAPNILLAENLNLLSSSDKKLTILHTNDQHSRIEPFDSTYSKNPNQGGFARRAALIQKIREQDKNVLLLDSGDVFQGTPYFNFYGGELEFKLMSMMGYEASTMGNHEFDNGLEGFKKALPSAKFPFICSNYDFENTVLEGQTVPYKIINKNGIRVGIFGLGIELAGLVGKKSYGETKYLDPVEIAQHYSDLLRKEKKCDLVVCLSHLGYDFRDYPTKVSDKILAAKTDGIDLILGGHTHTFLPEPQKMKNVSDQTVLVNQVGWAGLLLGRIDFYFDKNKAVKNISWHNQVIDDTILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Q8</accession>
    <name>C6X0Q8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen synthase-like protein</fullName>
            <ecNumber evidence="4">2.4.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00485"/>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06944">
        <property type="protein sequence ID" value="ACU06944"/>
        <property type="gene ID" value="FIC_00485"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00485"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085315_0_0_10"/>
    <dbReference type="OMA" id="HQLHEVI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="3">
        <location>
            <begin position="21"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="272" mass="31869" checksum="A1832994D1A26985" modified="2009-09-22" version="1">MHDRIFCSLYRRTIELMPNQKILYVTTEMFPYQEDSNIGVTVNKMSLKMHQQGNDVRVFMPRFGQISERKFQLHEVIRLSGMNIIINDLDQPLIIKVASLPGERLQVYFIDNDEYFKRKQFYVDDEGQPFADNDERAIFFARGVIETIKKLNWVPDVIHLNGWMASFIPLYLKTFYKNDSYFKDSKIVLSVYNEEDSELDPSVENKLKFDNITSLKAFTKPSFRQFVIESMDLVDVVVKGDEFLQESLEEAFNNTKTQKSDVLGAESIETLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0T5</accession>
    <name>C6X0T5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase of the beta-lactamase fold-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01602"/>
    <dbReference type="EnsemblBacteria" id="ACU08048">
        <property type="protein sequence ID" value="ACU08048"/>
        <property type="gene ID" value="FIC_01602"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01602"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_0_2_10"/>
    <dbReference type="OMA" id="QHWTRRT"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="123"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="371" mass="42906" checksum="E4948F849FDC2C64" modified="2009-09-22" version="1">MKTLKKIMISLLIFIVLLASGTSLFLNQSQFGKAPSGKRLERIQKSPHYKNGRFDNLNKTPQLAEDTSMPEVMFRMFFGKTQDTKPRKPFSFTKTYLKTLKPEENVYIWMGHSSYFIQIDGKKILVDPVFSGNASPVSFTTKAFAGADLYSTDDIPELDYLIISHDHWDHLDFKTVKKLKPKVKKVITGLGTGEHLEYWGYDPAKLIELDWAESADLGDGVKVYCETARHFSGRGLKRDQAIWASFVFETPTQRIYIGGDSGYDTHFKKIGDKFGGFDLAILENGQYNRDWRYIHFMPGENINAMKDLNAKRMIPVHNSKFTLAPHAWYEPLDKMIELNTENLRIIMPKIGEKVNWQDDGKVYEKWWEQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0U3</accession>
    <name>C6X0U3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01610"/>
    <dbReference type="EnsemblBacteria" id="ACU08056">
        <property type="protein sequence ID" value="ACU08056"/>
        <property type="gene ID" value="FIC_01610"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01610"/>
    <dbReference type="eggNOG" id="ENOG502Z8PF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117646_0_0_10"/>
    <dbReference type="OMA" id="VMHVREC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970520" evidence="1">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="195" mass="22470" checksum="31F30C55BC401C1A" modified="2009-09-22" version="1">MKQKSMKQLLTLGFTVAFFTLNAQTADLPSEKFWQNLKKHCGKSYEGKITAGAKEGDGFSGERLVMQVLSCDEHRIRIPFYVGANQSRTWVLTKNENSILTLKHDHRHEDGSEDKVTQYGGTNSNHGFENLQMFPADQETAQRISYASTNMWWVTLDDKTYTYNLRKIGSDRVFTATFDLTKPVEFNEKPWGWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0W2</accession>
    <name>C6X0W2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806360.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01630"/>
    <dbReference type="EnsemblBacteria" id="ACU08075">
        <property type="protein sequence ID" value="ACU08075"/>
        <property type="gene ID" value="FIC_01630"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01630"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_6_0_10"/>
    <dbReference type="OMA" id="CGIAKMN"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="230" mass="26129" checksum="98B4DE1B1CF62FB5" modified="2009-09-22" version="1">MGNFESWKDLLNPEFYIQMGGFWLILFIIFAETGLFIGFFLPGDSLLFVSGIYAVEIIEEAIGSTGSDFWDTTILATAVAVAAVIGNEVGYWFGLKAGPALYKKEDTFLFKKKYLFQAHDFFEEHGALAVIMARFLPVVRTFTPIVAGIVKMNKTRFLIDNIIGAFLWSFSLIFAGHYLDKLFLEQFDIDLKTHLEMIILIIVLLTTVPLLMKFFFGKKKDESHYKDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X1</accession>
    <name>C6X0X1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01639"/>
    <dbReference type="EnsemblBacteria" id="ACU08084">
        <property type="protein sequence ID" value="ACU08084"/>
        <property type="gene ID" value="FIC_01639"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01639"/>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099364_0_0_10"/>
    <dbReference type="OMA" id="FESSEGH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="233" mass="25778" checksum="36AD2838D92219FC" modified="2009-09-22" version="1">MISIIILLILSVILGVFLGKYFGAQQKFAKNLLILSAGFLITVCLNEVFPEVYAHGGANIGLFVIGGVLLQMLLENLTKGFEHGHFHHHHEEKNILPLALMIGMFVHAFLEGIPLANEHDASNPYLMGILFHNLPISFVLGAFLFHKNKKLSTSSWLVIAIFAIASPLGLLLGNYFNPDFKVYFLALVGGIFLHISSVIIFESNKNHNIDWPKILMVICGVALGMIGHLFHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Z7</accession>
    <name>C6X0Z7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase chain G</fullName>
            <ecNumber evidence="5">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806395.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01666"/>
    <dbReference type="EnsemblBacteria" id="ACU08110">
        <property type="protein sequence ID" value="ACU08110"/>
        <property type="gene ID" value="FIC_01666"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01666"/>
    <dbReference type="eggNOG" id="COG1034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_0_10"/>
    <dbReference type="OMA" id="LHMNRCI"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="4">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="335" mass="37855" checksum="B0C3DFB800D38990" modified="2009-09-22" version="1">MSEDIKKFKITIDGQTTEVAPGTSILEAARQIGGRSVPPAMCYYKPLENSGGRCRTCLVEVSKGSDADSRPMPKLVASCRTGVMDGMEVKNLTSEKTQEARKAVTEFLLINHPLDCPVCDQAGECHLQDLGYEHGLERTRTEFERRTFDSEDIGPYIKLNMNRCILCARCVLAANQLTDKREHGILFRGEQAEIATYLNKSLDNDFIGNVIDVCPVGALTDKTARFAQRVWFTKPVNASCSCEKCSGKVVLWMKGEEVIRVTARKDQYDEVEEWICNECRFERKDVKLWTIEGPRNIDRHSVISLNHYEKPQNMINLLNNPDAKEISVKDEKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X110</accession>
    <name>C6X110_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806408.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01679"/>
    <dbReference type="EnsemblBacteria" id="ACU08123">
        <property type="protein sequence ID" value="ACU08123"/>
        <property type="gene ID" value="FIC_01679"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01679"/>
    <dbReference type="eggNOG" id="ENOG50339XQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192796_0_0_10"/>
    <dbReference type="OMA" id="CRGLSNC"/>
    <dbReference type="OrthoDB" id="2042516at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972198" evidence="1">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="71" mass="7874" checksum="9978EE9E996F65B8" modified="2009-09-22" version="1">MKLLYLLFLTFLLSAGANHSQSGVYLCDSDGGKKYHFTKNCRGLSNCQHEIIKVTLKKAQSLGKTLCGHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X111</accession>
    <name>C6X111_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01680"/>
    <dbReference type="EnsemblBacteria" id="ACU08124">
        <property type="protein sequence ID" value="ACU08124"/>
        <property type="gene ID" value="FIC_01680"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01680"/>
    <dbReference type="HOGENOM" id="CLU_3043629_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="54" mass="6226" checksum="989CEE74A1EBCC28" modified="2009-09-22" version="1">MAYMLLPALLAGVFAGYLVYLFFWKNDPATLKSVLYPGLFFVSIWALLYYLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X136</accession>
    <name>C6X136_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806434.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08149">
        <property type="protein sequence ID" value="ACU08149"/>
        <property type="gene ID" value="FIC_01706"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01706"/>
    <dbReference type="HOGENOM" id="CLU_1537817_0_0_10"/>
    <dbReference type="OrthoDB" id="1566441at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="174" mass="19834" checksum="785F762313158AC2" modified="2009-09-22" version="1">MMKKLLFAVVLISGWSFGQETVKDSKGNSIKLNSDKTWEYVPNAEPGKLQMSDFTPLSTKISAGVLPKKKIAVLNGVNEPTETEFLFLSDRDKFANITIEKINRMIDLSRAALIVKSRNWPSFSPKAVTVAWSDSTNSWMIGWTYTILNTDAEPTEQYKIYYFTNESEELFERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X137</accession>
    <name>C6X137_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01707"/>
    <dbReference type="EnsemblBacteria" id="ACU08150">
        <property type="protein sequence ID" value="ACU08150"/>
        <property type="gene ID" value="FIC_01707"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01707"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062378_0_0_10"/>
    <dbReference type="OMA" id="THWEYWP"/>
    <dbReference type="OrthoDB" id="1086102at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="382" mass="44475" checksum="6FACBAB051E8E2D7" modified="2009-09-22" version="1">MCAFASEHVNDGPTPTANENWLHRLSSEHYMLVKNIIYKINHWETWDWRLKYVPILPVWIWNCIRAKSWWFFSPSNPKLTFGGFEGVSKMSIYQHLPPGTYPPSTGIKANLTFPEMQKLVEDRYAYPFVVKPDVGRMGYMFRIVRNASELKAYHEIMPVDYLVQELVLHPLEVSVFYYRFPDQKSGTITGFVRKEFLEITGDGHSTVDELMAASPHTCFRLEELRAKHLDKLHLVLQKDEIFCLSYALNLSRGCSLISLEDEIDENLVKVFDELSSYSDTLFYGRYDIKCASIADLKQGKNFSIIEYNGCGAEPHHVYGNGNTLFKACRILAQHWLILAEISRYNYSKGVRYISFRQGWETMRSCRKYFAKLRKLDAAFPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1D5</accession>
    <name>C6X1D5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806533.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01805"/>
    <dbReference type="EnsemblBacteria" id="ACU08248">
        <property type="protein sequence ID" value="ACU08248"/>
        <property type="gene ID" value="FIC_01805"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01805"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_2_10"/>
    <dbReference type="OMA" id="WLFEESY"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026333">
        <property type="entry name" value="ATP_dep_DNA_lig_pp_1105_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04120">
        <property type="entry name" value="DNA_lig_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="6">
        <location>
            <begin position="303"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="526" mass="60699" checksum="43528CEF2BDD3336" modified="2009-09-22" version="1">MKHFAELISSLESSNKTTAKVDAMVHYLRTAPENDKLWFLALFTGKRPKRPVNTNLLRQWALEIIQLPEWLFLESYSSVGDLGETISLILPPPQNDISKSLSQWMDELGDLAHKTEAEKKAYVTESWNGLDYTERFIFNKLIGGSFRIGVSKKLLISALSKYSEIDSSQLMHSIMGKWDINEINFEDLIAGININPDNSKPYPFCLAYPLEKETDELGDPAEWQAEYKWDGIRGQLIRRNDEVFIWSRGEELVTPQFPEIVSALEKMTGNFVIDGEILAVTEKGVLNFNELQKRLNRKTISAKMLKEIPVKVFAYDILERDDEDLRGKPLTYRRKILEELIHSQAPENITLSDIVPFQKWEDLVEVRDNSRLNNSEGLMLKHKESLYHSGRKKGDWWKWKVDPLTIDAVLIYAQKGSGRRSGYYTDYTFAVKKEDQLVTVAKAYSGLTDKEIMEVSRFVTKNSLEKFGPVRTVKPELVFEIAFEGIGLSNRHKSGVALRFPRILRWRRDKKADEIDDIEEVKKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1F4</accession>
    <name>C6X1F4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01824"/>
    <dbReference type="EnsemblBacteria" id="ACU08267">
        <property type="protein sequence ID" value="ACU08267"/>
        <property type="gene ID" value="FIC_01824"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01824"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_10"/>
    <dbReference type="OMA" id="VTEWRTH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="355"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="388"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="602" mass="68412" checksum="8A884793ABAC1DE9" modified="2009-09-22" version="1">MPKRFNRTINLYHIYKQLIPFIKPYRRMIYGTLLLTFVGALLAQVNPLVLKYTVDEVTELTKLPDPMAEGIHVLVLISAILLGKELLNIFIQFGQKFYGEKIRISTSSVLAQSVIDKILLYRVAFFNDENHESGKLQIRIDRGIESLTKLVQNFFIDILPLFSNAIIALVIMYMQNMYVGLVSTIVVPIYFYISALQAKKLSGVRRTLRNQREQKTSGLLNLINSIMVIKSFVREKFEGKKQYDLQMKLMDSQLFTRRTNFIYDGLKTFIEQFGVVLIILLTVFLVLDQQMTIGAIMLHILLFNNVSAPIRQLHRIYDDMNDAMIYAEGFFDILEADDQVEPTGDFVTESVEGKFELKNIDFSYPNGAKALNNVSMLIENGKTTALVGLSGAGKSTVINLLCKFYLPDSGEILLDDHRLDRFENTALRNDIGLVLQKNHIFQGSIEDNIRYGNMNATLEEIETAAKKAYLHEQIMDLPEKYQHDATQLSGGQQQRIAIARLFLKDPPIIFLDEPTASLDAIATEQIKNSLDAIKEGRTVVIISHSLSQILDADHIYVMRKGEVAESGTHDELIAMHGVYREIFDASARSLNLDKLVSSYREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M7</accession>
    <name>C6X1M7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01898"/>
    <dbReference type="EnsemblBacteria" id="ACU08340">
        <property type="protein sequence ID" value="ACU08340"/>
        <property type="gene ID" value="FIC_01898"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01898"/>
    <dbReference type="eggNOG" id="ENOG503257C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089968_0_0_10"/>
    <dbReference type="OMA" id="VLDWWIA"/>
    <dbReference type="OrthoDB" id="1226328at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021958">
        <property type="entry name" value="DUF3575"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12099">
        <property type="entry name" value="DUF3575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="264" mass="29262" checksum="B2BD2BFDCCFF0A48" modified="2009-09-22" version="1">MNAINAALRALIKRSRLSLKKLLNQITMRNLILTLLLPAAMFSQTAPVQKMNIVKTNVTGYVFRNVNLTYERVINQRFSVAVGFGTVAKGGVPFSKSFIDDTEFSDVEVSQTNFTIEPRIYLGQGYGRGFYFAPYYRHTTFNAEQITLDVDFSGDTVPMNIAGEAKGNSAGLMVGAQWFLGKTDSWVLDWWIAGAHYGGGKGDFRAQSPRSLTADEQAELRDEIENLDIPYVDYTVTTDPNGANINVDGPWAGLRTGLSIGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P1</accession>
    <name>C6X1P1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.129" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806639.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01912"/>
    <dbReference type="EnsemblBacteria" id="ACU08354">
        <property type="protein sequence ID" value="ACU08354"/>
        <property type="gene ID" value="FIC_01912"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01912"/>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061249_0_0_10"/>
    <dbReference type="OMA" id="ECVTINR"/>
    <dbReference type="OrthoDB" id="971098at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="6">
        <location>
            <begin position="173"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="262" mass="28523" checksum="5DB93D42CBFCDB72" modified="2009-09-22" version="1">MVHQLAAVDKRAQIKKNVIVEPFTTIAGDVIIGEGTWIGSNVTIMDGARIGKNCRIFPGTVISAIPQDLKFDGEDTQVIIGDNTTIRECVTVNRGTKALGYTKLGNDCLIMATSHIAHDCIIGNGVIIVNGCGIAGHVEIGDYTVMGGLSAIHQFGKIGKHVMISGGTLVRKDIPPYVKVAREPMTYAGINSVGLRRRGFTNEKIFEIQKIYRAIFQMKMNVSQASSFIEKEMLPTVERDEILEFIKNSPRGIVKGYGTGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q6</accession>
    <name>C6X1Q6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="11" type="ordered locus">FIC_01927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806654.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01927"/>
    <dbReference type="EnsemblBacteria" id="ACU08369">
        <property type="protein sequence ID" value="ACU08369"/>
        <property type="gene ID" value="FIC_01927"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01927"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_10"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="134"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="367"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="440" mass="50407" checksum="9451477BA04BB795" modified="2009-09-22" version="1">MRTKSVGKKQINIVTLGCSKNVYDSEVLMGQLQANGKKVVHEDRGDIVVINTCGFIDNAKEESINTILDFVEAKNRGEVEKVFVTGCLSERYKPDLIREIPDVDQYFGTRDLPILLKQLGADYKHELIGERMTTTPKHFAYLKIAEGCDRPCSFCAIPLMRGKNISTPIENLVIEAEKLAKKGVKELILIAQDLTYYGLDLYKKRALGDLLLRLVKVDGIEWIRLHYAFPTGFPEDVLEIIKNEPKVCNYIDIPLQHINSDILKAMKRGTSHEKTNALLDKFREKVPNMAIRTTLIVGFPGETEERFQEMKEWVRTQRFDRLGCFTYSHEENTTAFVLEDNVQQEVKEARVEEIMELQSQISWEKNQEKIGKTFRCIFDRKEGNYFVGRTEFDSPDVDNTVLVSAENTYLAIGTFENIRITSAEEFDLYGEVVTNNEFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U2</accession>
    <name>C6X1U2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01963"/>
    <dbReference type="EnsemblBacteria" id="ACU08405">
        <property type="protein sequence ID" value="ACU08405"/>
        <property type="gene ID" value="FIC_01963"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01963"/>
    <dbReference type="eggNOG" id="ENOG5031C3G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066214_0_2_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005901">
        <property type="entry name" value="GLPGLI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09697">
        <property type="entry name" value="Porph_ging"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01200">
        <property type="entry name" value="GLPGLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="249" mass="29432" checksum="BA41E69A1002949C" modified="2009-09-22" version="1">MQYRYTKQTSKVDTALLRQHVFLVMRDNESMFFSEAAYVSDSVFAENTKNGVRTDFKNLPEDHLRGFVKKNLNLQTITYYSDEFDDLEFQYDEKPDFKWQITAQNKQVLGYKVFLAKTSYMGRQYSAYFTTEIPVSDGPYKFFGLPGLILEIFDDEKKHHFEAVGIAEGRQIHLDLESRKFKETDKLKFNTAREAYRKAPLQRLIQLMNSSQIYEVPDKNGDVVDLRKLFEENQRTMIKQFQNENNIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1W9</accession>
    <name>C6X1W9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806717.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01990"/>
    <dbReference type="EnsemblBacteria" id="ACU08432">
        <property type="protein sequence ID" value="ACU08432"/>
        <property type="gene ID" value="FIC_01990"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01990"/>
    <dbReference type="HOGENOM" id="CLU_2395385_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="93" mass="10701" checksum="C1957306D4736895" modified="2009-09-22" version="1">MFKSQKSKWIALAIILLLALNFIALYVLNQSIDNRKLIPHANAGMKDSFQQQEMFSDIFSSAVFTFDIFGVLILLYFLIKMLFRKMKTSSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Z5</accession>
    <name>C6X1Z5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 9">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplV</name>
        <name evidence="10" type="ordered locus">FIC_02016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6 9">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806742.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02016"/>
    <dbReference type="EnsemblBacteria" id="ACU08458">
        <property type="protein sequence ID" value="ACU08458"/>
        <property type="gene ID" value="FIC_02016"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02016"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_1_10"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="132" mass="14887" checksum="790573D1872D04F8" modified="2009-09-22" version="1">MGSRKRESALARKIANQDVAKALHNDCPSSPRKMRLVADIIRGIEVDKALAILKFSKKDASNKLEKVLLSAMANWQLKNEDADIEEANLIVKEIFVDSARQLKRLRPAPQGRGHRIRKRSNHITLILGTKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X219</accession>
    <name>C6X219_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806766.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08482">
        <property type="protein sequence ID" value="ACU08482"/>
        <property type="gene ID" value="FIC_02040"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02040"/>
    <dbReference type="eggNOG" id="ENOG502Z84C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_882320_0_0_10"/>
    <dbReference type="OMA" id="PRIDMLN"/>
    <dbReference type="OrthoDB" id="1111183at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="385" mass="44860" checksum="50E36F5867C8B483" modified="2009-09-22" version="1">MSDLDLLHFEQLKNEVQTQYLEKHSPSSDDIAKWKGIDIIYFQEDLRKKAKGNISEKSFYTYFKTSPVTKLPRIDMLNILSVYAGYVSWYDFKKNHLFSDEILKDNEDYAEAEPNSTVINNSDDPDPEKLNSEEKTLQKDDIKSDENHVLQNTDYVNQTVNENNSVLETYDIQDRKTTFSVVKKYIWIGVSVILALLVGLLGFKDEIFSKKYYYSFIDADRNSKINAELQVQILKENESPILYVAKPNEPFVYTTKSKNLTMVVSSPYYRTDTIHRNLETAPEAENIELKPNDYAIMLFYYSKSITDLKKKRISLNYLISNDALIYQVFDNQFYGVETMDKQRYINLVTLPSTSLENLDVIDTQTDKSGKIIMIKFKIDNDEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X220</accession>
    <name>C6X220_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_02041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02041"/>
    <dbReference type="EnsemblBacteria" id="ACU08483">
        <property type="protein sequence ID" value="ACU08483"/>
        <property type="gene ID" value="FIC_02041"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02041"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_0_2_10"/>
    <dbReference type="OMA" id="MPLVGFD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="145"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="209" mass="23733" checksum="97D1DB3B2777C0BD" modified="2009-09-22" version="1">MALRRSAIFCLNLNMNKSEIRKLYLAKRKGLPIEELMRMSEEIFKNFIAEFKPVTNQKVHCFLSITDKHEVNTVPFLNYFFTNSIRVFVPKIVDGKMISLEINSDTRLVKNSWGIAEPESSKDSGESSFDFVLVPLLYADRSGNRVGYGKGFYDTFFATVNANAFKIGLNFFSPAEEISDVWENDVSLDYLVTPTEVLSFAGGTSKFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X238</accession>
    <name>C6X238_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806785.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02059"/>
    <dbReference type="EnsemblBacteria" id="ACU08501">
        <property type="protein sequence ID" value="ACU08501"/>
        <property type="gene ID" value="FIC_02059"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02059"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_10"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="320"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="540" mass="61436" checksum="2FD147F348432B6F" modified="2009-09-22" version="1">MLTVSNLSLQFGKRILFDDVNIMFTKGNCYGIIGANGAGKSTFLKILTGQQDPTTGSISLEPGKRMSVLEQDHFAYDDLTVLETVLRGNKKLFVIKEEMDALYAKEDFSDADGIKAGELGVIYDEMGGWNSESDAMTMLSNVGIKDEMHYQLMGELENQNKVKVLLAQALFGNPDVLILDEPTNDLDIETIAWLENFLADYENTVIVVSHDRHFLDTVCTHIADLDYSKLNLYTGNYSFWYQASQLATRQRQQANKKAEEKKKELQDFIARFSSNVAKAKQATARKKMIDKLNIEDIKPTSRRYPAIIFDTEREAGDQILEVKNLEKTKDGELLFSKIDLNLKKGDKVAILSKNSLAITEFFEVLSGNTTADKGEFNWGITTNQSYMPLDNNGFFQDDINLVDWLRQYTKNDEERHEEYMRGFLGKMLFSGDEALKSCKVLSGGEKMRCMFSRMMLQKANVLLMDEPTNHLDLESITTLNNSLTNFKGNILLSSHDHEMLQTVCNRIVELTPKGIIDREMSYDEYLADKKVKELQQQMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X243</accession>
    <name>C6X243_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AsmA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_02064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02064"/>
    <dbReference type="EnsemblBacteria" id="ACU08506">
        <property type="protein sequence ID" value="ACU08506"/>
        <property type="gene ID" value="FIC_02064"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02064"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002997_0_0_10"/>
    <dbReference type="OMA" id="FIRSPWG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA" evidence="6">
        <location>
            <begin position="17"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1682" mass="186889" checksum="2467D484CC27DA62" modified="2009-09-22" version="1">MFKLRILHIQHSMTTFKKILKYTAIFIGSLLLLLVILALSLQLPGVQNFAKGKLVNYLEEKIHTKVRLDRVYVGFPNSLVMENLYLQGQEVDTLLFAKKLDVGLNIPKLLKNTADLTSIDLQGVKANVVRSKDGRFNFDYIIDAFATKDSEESESKPFIISLDKIKLRDIRVSFIDQQSRNDIALYFKSFDTRVKTFDLQNNSYAAGDINMDGLRLKLKQDLLEEVAENVEEKVDSLNQQKPMKIGLNKIKFTNFNIDYGDDNSKTFAKVIFKELSTKINQLDLEKNTYGIENLILKGADINAKLFMPAQNANPSNEDKKDESSQTEGSLALLLNKLQLEDVKVVYDNTAMARTRSGIDFNHLNFTKMNLEVRNFRMQDGTFAGTVNSAEIKESRGLDIQKFNTDFVYDNEQAYLKDLYLQTPKTVLRDELALNYNSMEQLSANPGAVRIAANIQNSKIGFSDILMLAPSLRSTAPFNKYPNAILKINTRLRGTLNDLQIQTLQLSGIDQLKVNASGKIRNAMNPAQLAYDLNVRELSSSAKTIYNLVPKNTIPSNISLPSHLNISGTAKGTTEIVNANLRMISTLGNAAVRASVDMRRKNQERYDILANLQNLQIGKIIQNKDLAGITGQVSVKGQGFALNSAIADIKGNIGSVYYNGYTYRNMALAGKINRGAYVLNLDSKDPNANLKLLASGVYRENNPTVKVNGSIRKLDLNKLGFYSDPMILAGNLDADFTSLNPDAPNGYLHLENFAISDTKDIFPLQEVYLTAVSTADSNRIVLQSQVADVDLSGKYKLTQIFGSLQQTINQYYQFQKPGTKAARIDPNQYFTFNAIIKDDNLLRRFVPDLTEFEPITLAGNYDADSRKLQVNGQIPQVTYGKNIIRGGTIAVDNQNDALVYNVQLAEFNNESIALMKVGLVGDIRDNLITYNASTKDEKDETKFLVAGNAQKVGDLTQIRLNPDGLKLNYTNWQVTPDNYLQLGNGGIFANNFGISNEGSQILLQSESRSANSPLNISIKDFKIETVTELVKKDSLLASGNINGTAQLRNLQSNMTFDADIDMTELFVYGSPVGNLDVKANSESGNLIRADVALSGFNNDAKLFGTFNSATSTFNMNLDLNQLQMQTVQGLTMNAIENAEGYLSGDLKITGNTSAPQIRGDVKFNDVGLGITQLGSKFSNINDEINFTSRGIDFNQFKINDDSGNSIIIDGAVLTQTYTDFTFNLDVDADDFKVVDSEKNNDRMMYGILAIDADLSIRGDLDLPRVDGNLSVTDVTDFTFVLPTSSPSLQDREGIVEFIDQDQIALQETITTEALTHQSDIKGMDVNVNIDVTKEAKISLIIDRANGDFVKLQGDAQLTGGIDPSGKTTLVGVYEVDQGAYEMSVSLLRRKFDIQKGSTITWTGEPTTANLDVTAVYKTDAAPLDLLQQQLTGASGSELNQYKQRIPFNTLLIMKGELMKPVISFDITTDEENSSVSATVLDNTKTKLEQLRREEAELNKQVFALLLLNRFIGENPFQSDSGLSASTIAKQSVSRILSEQLNDLASDLIGGVELNFDLESTEDYSTGSRNERTDLNVGLSKTLLDDRLTVTVGNNFGLEGDARKNEQMTNIAGDITLDYKLSRDGRYMLRAYRKNDYQVALQGQIIETGVGFIITLDYDKFREIFERAKRNKELRKQKRLQKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2A5</accession>
    <name>C6X2A5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02132"/>
    <dbReference type="EnsemblBacteria" id="ACU08568">
        <property type="protein sequence ID" value="ACU08568"/>
        <property type="gene ID" value="FIC_02132"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02132"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124370_0_0_10"/>
    <dbReference type="OMA" id="NAPHICP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="168" mass="19002" checksum="71396BE87947F231" modified="2009-09-22" version="1">MPDNDFFVDSFYKYINLFRMMVKFSSVLSAIVLIFSLLITSSCREREETVRCFPDVPISVILNLNLPAYYNLQNVNGFIYVNEQQSGTRGLIIVRTTNGFKVYDRNAPHICPDTDTTLEVASNTKIVCPKDGAEWILITGEPIKNATISPKTYRHSFDANSGILTVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B5</accession>
    <name>C6X2B5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="7" type="ordered locus">FIC_02142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02142"/>
    <dbReference type="EnsemblBacteria" id="ACU08578">
        <property type="protein sequence ID" value="ACU08578"/>
        <property type="gene ID" value="FIC_02142"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02142"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_10"/>
    <dbReference type="OMA" id="RMASVNG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="52" mass="6095" checksum="EF18C15C8676518C" modified="2009-09-22" version="1">MSKRTFQPSERKRRNKHGFRERMSTPNGRRVLAARRAKGRRSLSISGARAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F1</accession>
    <name>C6X2F1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02178"/>
    <dbReference type="EnsemblBacteria" id="ACU08614">
        <property type="protein sequence ID" value="ACU08614"/>
        <property type="gene ID" value="FIC_02178"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02178"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035211_1_0_10"/>
    <dbReference type="OMA" id="RAWGIGQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="273" mass="29151" checksum="4E1B6070A555EE0E" modified="2009-09-22" version="1">MNCRMRLPSLKNFLAFLFLGLNIFVFAQLVPARPAKIFPVTDEVGLLTATEREQINSKLIKFHDSTSTQIAVIIVPTTKGEDINYLATMYGEKWGIGEKEQDNGIVFLIATEDRKFSIQQGRGVERYLTASVTGQILDYLVTPSFKQGLYYEGINRGTTALMEVVEGKFKPIAKTNSKGGVSPFKIVLIAFFIFMILSVLFKNKGGGGRNDDDDDVILSRRGRRSYPGGFFPFPGSFGGGGFGGGGGFGGGSGGFGGFGGGGSFGGGGASGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H2</accession>
    <name>C6X2H2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02200"/>
    <dbReference type="EnsemblBacteria" id="ACU08635">
        <property type="protein sequence ID" value="ACU08635"/>
        <property type="gene ID" value="FIC_02200"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02200"/>
    <dbReference type="HOGENOM" id="CLU_3183953_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="46" mass="5406" checksum="3CE7C2DB280F12C0" modified="2009-09-22" version="1">MLGLNLVGNLIVSKQNLIVSKKSNFIRKFYFSYDFGIINHNVFSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2L3</accession>
    <name>C6X2L3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806960.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02243"/>
    <dbReference type="EnsemblBacteria" id="ACU08676">
        <property type="protein sequence ID" value="ACU08676"/>
        <property type="gene ID" value="FIC_02243"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02243"/>
    <dbReference type="eggNOG" id="COG4874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077407_0_0_10"/>
    <dbReference type="OMA" id="FIEFCED"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014541">
        <property type="entry name" value="Amdntrnsf_FN0238"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43224">
        <property type="entry name" value="PTHR43224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028188">
        <property type="entry name" value="Amdntrnsf_FN0238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="309" mass="35344" checksum="490D17E0A4D293BD" modified="2009-09-22" version="1">MQAASTVLMIEPIAFGFNAQTAENNYFQTDQQNVDTQLKALHEFNTFAEQLRSKGIRVITVKDTLNPHTPDSIFPNNWVSFHHDGKVVLYPMFAPNRRVERRADILEILKNEGFEINEVEDISHSESDERFLEATGSMIFDHDHKIAYGSVSLRLDEKLFRKFCADYGFTPVVFHSYQNANGARLPIYHTNVMMCVADQFVVICLECIDNELEREKVQEVIKSTSKEIIEISEDQMQQFAGNMLQVKNVDGKKFLVMSETAYKSLTQDQIDRIEKYCEIIHANLDTIETNGGGSARCMLAEVFLPLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P6</accession>
    <name>C6X2P6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ordered locus">FIC_02276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806993.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02276"/>
    <dbReference type="EnsemblBacteria" id="ACU08709">
        <property type="protein sequence ID" value="ACU08709"/>
        <property type="gene ID" value="FIC_02276"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02276"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_10"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp_2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="7">
        <location>
            <begin position="272"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="331"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="398" mass="42650" checksum="2886301F855D00C0" modified="2009-09-22" version="1">MNLHEYQSKEILAKYGVTIQRGFVANNVEEAVDAANKLKEMTGGAEGWVVKAQVHAGGRGKGGGVKFSPNLEKLKENAQNIIGMQLVTPQTSAEGKLVNSVLVAEDVYYPGASETKEFYVSILLDRAQGKNMIVYSTEGGMDIEHVAEVTPHLIHNETIDPATGLQGFQARKIAFNLGLSGAAFKDFTKFITSLYNAYVGIDASLFEINPVLKTSDDRIIAVDAKVSLDDNALFRHKDLAELRDTREEDPTDVEAGEAGLNFVKLDGDVACMVNGAGLAMATMDIIKLSGGNPANFLDVGGTADAERVQKAFGIILKDPNVKAILINIFGGIVRCDRVAQGIVDAYKAMGSLPVPLIVRLQGTNAVEAKQLIDDSGLPVHSVITLEEAANKVKEVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S8</accession>
    <name>C6X2S8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807025.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02308"/>
    <dbReference type="EnsemblBacteria" id="ACU08741">
        <property type="protein sequence ID" value="ACU08741"/>
        <property type="gene ID" value="FIC_02308"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02308"/>
    <dbReference type="eggNOG" id="COG1577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918117_0_0_10"/>
    <dbReference type="OMA" id="SGYDIAC"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="302" mass="34049" checksum="CCD3C52531F157CE" modified="2009-09-22" version="1">MTGRIFSPGKLLLTAEYTVLDGALALAVPTKWGQEFFFEEIEDGEAIVCWEALHQDKLWLQATINYAAWEVAQTNLPEPAQFILKVLQNVAQLSSLKFKSTTSYRLKTNLQFPPDYGLGSSSTLINNLAEWAAIDAFTLNEMSLGGSGYDIAVAKEKSAIVFQNTAGRKISEPVNFSPPFLDELIFIHLNQKQNSREGIELYRSKNVSADVIDWFSEFTQKVILCEDVEQFSGLMASHEQKLSNYLLIKTAKEKHLPGCPVFVKSLGAWGGDFVMSRKFPNYESYFSELGFTHIYTWKELIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U3</accession>
    <name>C6X2U3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02323"/>
    <dbReference type="EnsemblBacteria" id="ACU08756">
        <property type="protein sequence ID" value="ACU08756"/>
        <property type="gene ID" value="FIC_02323"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02323"/>
    <dbReference type="eggNOG" id="ENOG502ZIRP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823232_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="337" mass="38306" checksum="81E68E5C66013DDA" modified="2009-09-22" version="1">MNSTFLKHTHLKINLFPRLIFAALLAFAVSTVIYFSFGNIYSSALFTYGEFKAQFDSGIYRYRILSGYFVLAVYGVLSDLNIDFEVLKLKFFAKNADPAMYLSFYIVNTFFLMISAVVMMLITETKSFTATHAEKILLVSVAVFTIALSQFVIVPYDVPGYFMQLLFFLLLIKYTAKPNTAQLLVLVILVVVSTLNRESSALSIALAATVLYTKYGLKKETLIPLALIVAPFLAVYLGMRLFNDSFVTNDGNLLWQNFTQPKNILGLFIWILFLVFSLILAKDQTAAKYILLFHVFSAPYIMMCFYSGILYEIRLYVPIFITSLFLGRTVMTRHSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2U5</accession>
    <name>C6X2U5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807042.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02325"/>
    <dbReference type="EnsemblBacteria" id="ACU08758">
        <property type="protein sequence ID" value="ACU08758"/>
        <property type="gene ID" value="FIC_02325"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02325"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_101_4_10"/>
    <dbReference type="OMA" id="NEFTIHE"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="42"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="408" mass="45698" checksum="13BFB152D1566E48" modified="2009-09-22" version="1">MLALKAENISKQYRLGQVGTGTLTHDINRMWHQMRGKEDPYLKIGEANDRSTKGASEYVWSLRDINFEIEQGDAVGIIGRNGAGKSTLLKLLSKVTKPTTGKIYTKGRIASLLEVGTGFHPEMTGRENIYLNGAILGMTRKEIARKFDEIVDFSGVERYIDTPVKRYSSGMYVRLAFAVAAHLESEILIVDEVLAVGDAEFQKKCLGKMGDVSKGEGRTVLFVSHDLNAVSQICNSGILLNQGLVEYKGNIRETVSTYLNSDSDAVIYLNSNKKVGKKMFIQEIQVVKTNGEISKEYLYDEPINFKFTIAINEFVPGTSFFVTVLDSRKKRVFSCEKLMVDPDMTLTIEPHTLVRGNYSIHAFINQPKVAQLDVAEDVCKFTVSDPDSYLAKHGEYDYGSVFGRYQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z0</accession>
    <name>C6X2Z0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807087.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02370"/>
    <dbReference type="EnsemblBacteria" id="ACU08803">
        <property type="protein sequence ID" value="ACU08803"/>
        <property type="gene ID" value="FIC_02370"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02370"/>
    <dbReference type="eggNOG" id="COG3178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021467_0_0_10"/>
    <dbReference type="OMA" id="HSRNLMV"/>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="339" mass="39073" checksum="405D32751110805E" modified="2009-09-22" version="1">MGIDKAQLFFGEFIGEPVQDLVLLAQSGSARKNFVGQTTDKKYIITSNGNVAENESFFYFSTLFSALNFNTPEILKISNDRKMYVQEFLGAQTLSEIIADDGINARTEALVKQTLKKLAELQRKTQTGVDYTKTFEYEKYDSLPITNDLFYFKSFVADVLEIPYHKSSLLKEFRKLTELLEDLGPQGLMIRDFQSRNIIVNERDEVFFIDYQSAMQGPLMYDVVSFLFQAKANFPKEFKEEMLGYYLSLWEDEAEIAQLKHSVEPLQLIRYLQVLGAYGFRGLIQKKEHFLSSLEKGIENLNSFAQNWEDMKEYPELAKLISALKSDIVGQKIERFASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X308</accession>
    <name>C6X308_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS</name>
        <name evidence="11" type="ordered locus">FIC_02388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02388"/>
    <dbReference type="EnsemblBacteria" id="ACU08821">
        <property type="protein sequence ID" value="ACU08821"/>
        <property type="gene ID" value="FIC_02388"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02388"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_3_1_10"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="619"/>
            <end position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="868" mass="98446" checksum="A90A67659D718DC9" modified="2009-09-22" version="1">MAPNQPHPMAKKETPLMTQYNTIKAKYPDALLLFRVGDFYETFGSDAVRTAQILGIVLTRRANGEGHIELAGFPHHSIDSYLPKLVRAGLRVAICDQLEDPKTVAKGIVKRGVTELVTPGVTFNEQVLSSKKNNFLLSVHKEKEKFGMALVDVSTGEFLVSEGNLEKLLHIVHTFDPSEIIYQRSTELPSQLKNKSSFKLEDWAFQHNYAYEKLTNHFRTASLKGFGIEEYKLGIVAAGAIFAYLVEDTHHALLQHITKIKLIPQEDYLMMDNFTLRNLEIVYPSNPQGKSLLDIIDKTSTPMGGRLLRRRLILPLKSVDEINRRLSLIEFFNKEDHLKYEIQQLLKSVSDLDRLMGKLASEKICPKEVGYLRQSLVNIHQIKNLLHKFDEVFAWLDPLNDLEELIRYLQNYLNDELPVNIAKGNVIKEGISEELDHLRGLQRKGKNFLDEMCERETARTGISSLKISFNNVFGYFIEVRNTHKDKVPTDWIRKQTLVNAERYITEELKEYEEQILGAEEKISKIEHELYRKVCDNVMVYIDSIQDNSKIISELDCGVGLSELAVSESYTRPVLNDSFEISLKEARHPIIENALPLGEKYIPNDLFLDKDSQQIIMVTGPNMAGKSAILRQTAIICLMAQVGSFVPAKYAEIGILDKIFTRVGASDNISAGESTFMVEMNEAANILNNISDRSLILLDEIGRGTSTYDGVSIAWAIAEYLHQHPTQAKTLFATHYHELNEMTVNFERIKNFHVSIQENKGNIIFMRKLLPGGSEHSFGIHVAKLAGMPAKVVNRANEVLKTLEKSRTQSGSKDKTKAITDENMQLSFFQLDDPVLENIREELTKIDINTLTPIEALMKLNSIKKMIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X332</accession>
    <name>C6X332_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807129.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02412"/>
    <dbReference type="EnsemblBacteria" id="ACU08845">
        <property type="protein sequence ID" value="ACU08845"/>
        <property type="gene ID" value="FIC_02412"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02412"/>
    <dbReference type="eggNOG" id="ENOG502Z9H6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762332_0_0_10"/>
    <dbReference type="OMA" id="LMTDNNF"/>
    <dbReference type="OrthoDB" id="1086709at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="386" mass="40945" checksum="418210F424E179C4" modified="2009-09-22" version="1">MKRILFLLMFSFLMISCKKDKVDASSTQALQSSINDMASGLATLQQVKFNEALYILKTFGVDAEGDVNELNALGKLINGMKVPQILALADQVAQQNGIDWTSTGPPSLGEMNIFGDEQATESDPNDISAKSLSLAITPVGNDSILGPKALQIVPRLLDTSGKPIVFSGAALEVTLEVFSSGNRILTAKNLMTDNNFKGFSLRFASLPSQKIVDNRIDITVSAKTAKKTFKMSKIGVAVNPKALLMPSGTPTDNPGTPITDPGTELPSDTSAGTEIQPAAPAADPKVSVTRFLNNLGSQNLRGAYDVADNPNWGSYETFSNPTSGFGAVKNINVKNITTNNAAGSSASVNATYDVTDKTGKTTALQVTFGLKNVNGEWKISSYKINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X398</accession>
    <name>C6X398_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807195.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02478"/>
    <dbReference type="EnsemblBacteria" id="ACU08911">
        <property type="protein sequence ID" value="ACU08911"/>
        <property type="gene ID" value="FIC_02478"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02478"/>
    <dbReference type="eggNOG" id="COG0700">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037414_0_0_10"/>
    <dbReference type="OMA" id="SNAQIMF"/>
    <dbReference type="OrthoDB" id="325457at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="2">
        <location>
            <begin position="108"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="2">
        <location>
            <begin position="334"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="467" mass="50415" checksum="B43F9CB9198A4138" modified="2009-09-22" version="1">MVLSRIWSAFIIVAIIVASIKYLASDHYKAIYNDMVVGKSGDTVQIASKNINQLDPEAQKALLIQPDFEQNRIHYRADSATSVVNVYRVQETDGVIGTSETAVKICIGLIGIMTLFMGFMSIAEKAGGINLLSRMIQPFFSRLFPEIPKNHPSFGHMLLNFSANLLGLDNAATPFGLKAMESLQTLNPDKERASNSQIMFLCLHAGGLTLIPVSIIAIRASMGSATPTDIFLPCMIATFAATMAAMIIVSLYQKINLLQPVVIAYVGGISVIVGLLVVYLVNLTKEGLEGFSMLLSNGIILLIFFAIVLGALYKKINVFDAFIDGAKEGFWTCVKIIPYLVGMLIAISLLRTSGVFDVLIDGMKWVAAVAGFDTRFVDGLPTALIKPLSGSGARGMMVDTMQTFGADSFQGRLAAVLQGSSDTTFYVIAVYFGAVGIKNTRYTVTAMLLADLVGIITSVILAYIFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3B8</accession>
    <name>C6X3B8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">FIC_02498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807215.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02498"/>
    <dbReference type="EnsemblBacteria" id="ACU08931">
        <property type="protein sequence ID" value="ACU08931"/>
        <property type="gene ID" value="FIC_02498"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02498"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_3_10"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="288" mass="32641" checksum="E5FD45DA696DDD34" modified="2009-09-22" version="1">MKAAVYSQKSDLDTFLYLSKFVSELEKRGIQAILYEEMANAMEFSKIFKTFAGKEDLKEQKVDWFFTFGGDGTIVNSLLFVQDLEIPVVGVNTGRLGFLSSFTKEEVFLKLDDIIKGEVNVSRRSVIEIVSPDKTIFFPFALNDITVSRKETTAMITVDSYIDGEFLNVFWGDGVIISTPTGSTAYSLSCGGPIITPNNNTFVITPIAPHNLNVRPLIVNDDVEIRLKVESRVPQYSLSLDSRLVNMETDVEIILRKARFQILLIHPRDLSFYETIRQKLLWGKDKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D8</accession>
    <name>C6X3D8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase (GDP)</fullName>
            <ecNumber evidence="2">2.7.7.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.22" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02521"/>
    <dbReference type="EnsemblBacteria" id="ACU08951">
        <property type="protein sequence ID" value="ACU08951"/>
        <property type="gene ID" value="FIC_02521"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02521"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_10"/>
    <dbReference type="OMA" id="QRPMYEE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008928">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GDP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="360" mass="40889" checksum="D839EDBD6922DCE9" modified="2009-09-22" version="1">MSKSNNYCVIMAGGIGSRFWPMSTQKYPKQFQDILGTGRTMIQQTFDRISQIVPVENIYVITNKEYISLTEQQLPELSLENIVGEPMMKNTAACNIYMANKIAAKNPDANMIVLPADHLILKENVFLEKVQLAFGLAEKNDYLITLGITPTRPDTGFGYIQFLEKKDSDYFKVKTFTEKPNAEIAKSFIESGDFLWNAGIFVWNVKSILSAFEHHLEEMAQQFVSCDYNSKDEETCIETIYPKVAKISIDNGILEKAKNVYVIPADLGWSDLGTWTSVYENSAKDDDRNAIQSKHILTYNSKGNIIQFKNKNKAAIIDGLKNFIIVDTEKALLICPRDNDQLIKDYIHDLKTQKKGDKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I3</accession>
    <name>C6X3I3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable periplasmic tail-specific proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02566"/>
    <dbReference type="MEROPS" id="S41.001"/>
    <dbReference type="EnsemblBacteria" id="ACU08996">
        <property type="protein sequence ID" value="ACU08996"/>
        <property type="gene ID" value="FIC_02566"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02566"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016199_1_1_10"/>
    <dbReference type="OMA" id="HHYSKPP"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020992">
        <property type="entry name" value="Tail_Prtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040573">
        <property type="entry name" value="TSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11818">
        <property type="entry name" value="DUF3340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17804">
        <property type="entry name" value="TSP_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="325"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="765" mass="87331" checksum="7F3292FEFB9A085C" modified="2009-09-22" version="1">MMPSSLVTSISGLCIQKWFSTKLLKIIASYINKVLILIPCTIAVTKRQIFLQIQISNYNMFKKLKINTLLLFIPLTSLAFCFNSPKNDDDKMSTIMVSVKNTLSYLHYSPKQINDAYSEDVYTQYFDMVDASKRYFLQSDMNEFAKHRTKLDDYLNRGDLTFYKLTIDRLYQRVDEIDKITQDILSKPINLDEEETLVLEPKIKKNPTNTAELSAEWKKYIKYNILQEMESLSAKEQSQKEKKDSVQKFNLKDTIKLEILTPEQKRVKATAEVKDLVTDTFRRFKKRNKMDWFTVYMNAYTEVFDPHTNYFSPKNKEDFDTQFTGKVIGIGAIIQEKKGFLHLGALTIGAPAWKSKQLSEGDKILKVRSKPDQDAVNVVGMLSDEAVRLIRGEKGTKVTLTVEKKDKTIKEVTMIREEVAIEDTFARSIIVNSADGKKYGFISLPSFNADFEDSKGRNASDDIKNELIKLKTQNVEGIILDLRNNGGGSLTEVGDIMGLFMNAGPYVQVKDGNGKIQTLKNKTNAPLWTGPLVIMQNELSASASEILAGAVQDYGRGVVIGSPQSFGKGTVQTFVDLNRFLNTNDDFGSLKLTIQKFYRVTGESTQRKGIESDIKMKDFYTYAEIGERYDDFALAWDKIPAVAYQPVSYFTMKALQSGVEERLANNKNYQLMQESAQWKENLDKEESISLNQAKFSQLMSARKSQIEKFRALEKYNNGLKFTLNTDEVGREKKDEAFAKKTQNWTKNLQRDMYLQEAVTVASQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3I5</accession>
    <name>C6X3I5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807282.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02568"/>
    <dbReference type="EnsemblBacteria" id="ACU08998">
        <property type="protein sequence ID" value="ACU08998"/>
        <property type="gene ID" value="FIC_02568"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02568"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101390_0_0_10"/>
    <dbReference type="OMA" id="RYASKAH"/>
    <dbReference type="OrthoDB" id="1705284at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="21265" checksum="6453FA1561E96B15" modified="2009-09-22" version="1">MEEILAKITDFGDKAHGDQRRKYSPDRYMVHPVRVMHTCRIYTNDISVLAAALLHDVLEDTPVTAAEIEQFLNGLIDAEETQNALGLIIDLTDVYTKEAYPKLNRRARKSKEVERLSKIRPNAQTVKYADIIDNSSEIVSSDPSFARVFLMEARAILQKMDRGNPELYKIAVETVNNALKAVDRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L9</accession>
    <name>C6X3L9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782154.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00549"/>
    <dbReference type="EnsemblBacteria" id="ACU07007">
        <property type="protein sequence ID" value="ACU07007"/>
        <property type="gene ID" value="FIC_00549"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00549"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064194_2_3_10"/>
    <dbReference type="OMA" id="ERGYADH"/>
    <dbReference type="OrthoDB" id="729805at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="148"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="237" mass="27049" checksum="E715666D946F22F4" modified="2009-09-22" version="1">MKTVYHKADTRGYADHGWLKSHHTFSFANYYNPERMNFGALRVLNDDQVASGMGFGKHPHRDMEIISIPLEGDLEHQDSMGTSAVIRKGEIQVMSAGTGVQHSEFNRNKDQLVKFLQIWVVPNKMNVTPRYDQISIKENEKINDFQQILSPNADDEGVWIHQDAWFNLAKFEKGNAKEYAIHQAGNGVYAFVLKGSAKIDEQILETRDGFGIWETETLTLEALEDSEILLMEVPMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3M4</accession>
    <name>C6X3M4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">purH</name>
        <name evidence="10" type="ordered locus">FIC_00554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782159.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00554"/>
    <dbReference type="EnsemblBacteria" id="ACU07012">
        <property type="protein sequence ID" value="ACU07012"/>
        <property type="gene ID" value="FIC_00554"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00554"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_10"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="505" mass="55682" checksum="E8A7500CB411520E" modified="2009-09-22" version="1">MSKKRALISVSDKTNLIEFAEFLEQNNYELVSTGGTFKHLKNAGLNPIQIDEVTGFPEMLDGRVKTLHPKVHGGLLAVRDSEEHMNTASEHGIGLIDMVIVNLYPFFENANSDISLDEKVEFIDIGGPSMLRSGAKNFKSVTVITDVADYAVIKKEIEETGNSTSETRKLLAGKVFNLTAAYDAAISQMLLTTDYPQYLNASYKKVSDLRYGENPHQTAAYYVSTTESGSMKDFEILGGKELSFNNLRDMDLCWKVVNEFKGEMACCAVKHSTPCGVAVGTLALETYRKTFECDPVSVFGGIIGMNFTVDAETAEELNKTFLEIVMAPDFDADALEILGKKKNLRIIKIKNAVSDDQTWVKIDGGMLVQDNDNKFSENIETVTDCKPTDVQIKALLFAQRVVKYVKSNAIVVSNGDQALGIGGGQVNRIWATQHAIERAKEKFSGDLVMASDAFFPFRDVVDFCAAEGITAIIQPGGSMRDNDSIEAANEHGIPMMFTGMRHFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3P4</accession>
    <name>C6X3P4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07032">
        <property type="protein sequence ID" value="ACU07032"/>
        <property type="gene ID" value="FIC_00574"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00574"/>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3007640_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="56" mass="6944" checksum="D22741D29DD98FD5" modified="2009-09-22" version="1">MFLNFKKMYFCYILYSKSLDRYYVGHTGENLDERLRKHLSHHHGFTSRAKDWIIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S2</accession>
    <name>C6X3S2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase, BNR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00605"/>
    <dbReference type="EnsemblBacteria" id="ACU07060">
        <property type="protein sequence ID" value="ACU07060"/>
        <property type="gene ID" value="FIC_00605"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00605"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064269_0_0_10"/>
    <dbReference type="OMA" id="FFDRRHG"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="384" mass="43784" checksum="D8DA6D75C18EF51F" modified="2009-09-22" version="1">MIWREFFIFRAAVSVFHSRFRRGGELRSSRAAIPLNFQKCIMKNIFLFCFSVLTGILYAQKPEIQTLLKDNISIRAIQIWDGKVWYAGTDSKFGYVSLKDTADQKQVSLSEKKLQFRTLAQDEQAFYAINIESPAYFFRIDKRTLKAEIVNGDDSKNAFYDALYFHKHTFYTFSDPEADLELKFAEFKMDNGTFYAKYYSDYLLNSGEAAFAASNTNIAAAKNYVWLATGGMSSRIFRLNTKNKDIEIFSTPFIQGTSSQGIYSIDFYSKKFGIAVGGDYTKQAENFNNIATTNDGGKTWQIQASGKNAGYKTCVKFRPGSKGKEIIAVGDQYIEFSGDYGQTWTIISEEKGLYVCEWIDRDTVILAGKNRIVQMKLNERGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S4</accession>
    <name>C6X3S4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_00607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782209.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00607"/>
    <dbReference type="EnsemblBacteria" id="ACU07062">
        <property type="protein sequence ID" value="ACU07062"/>
        <property type="gene ID" value="FIC_00607"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00607"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_5_10"/>
    <dbReference type="OMA" id="RIEVKHY"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="79"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="179"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="356" mass="41266" checksum="CFC28FDF84EFAC68" modified="2009-09-22" version="1">MDFTDKRYRFSPGSHHGSSVIWIAFEKDHELIAHLRAQTKARWSATQKKWYVADRRHYRELFGLPEEITGKAVLAKINLINLPEFKRFQEHLVLKGYSQSTLRTYSIEFAQLLYVLKGHPVNELSPERLRAYFLYCHENLKLSESEIHSRINAVKFYFEQVLHRHKMFFDIPRPKKKQQLPKMLSKAEIKKIILSVENPKHLMILKVCYGMGLRVSEVVALKLTDIDGAGKRVRIEQAKGKKDRITVLPESLLPELRAYYLAYRPKTFLFEGQHGGQYSVRSAQAVFKKAVEKAGIHRKLGIHGLRHSFATHLLETGTDIRFIQELLGHNSIKTTQIYTHVTDIAKAQIKSPLDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3S5</accession>
    <name>C6X3S5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782210.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00608"/>
    <dbReference type="EnsemblBacteria" id="ACU07063">
        <property type="protein sequence ID" value="ACU07063"/>
        <property type="gene ID" value="FIC_00608"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00608"/>
    <dbReference type="HOGENOM" id="CLU_118509_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="157" mass="18438" checksum="53E34F7B6E3CADAE" modified="2009-09-22" version="1">MLFTHCEKSNEEYLDDFKNYDVTLSNSDFDINLKNGKIESDYFKMMDSIKFSKKEKIEFAKLFFDNNLKKLNGDLVIYNNDGISIHPDIGTSIRIKYFAIDKSTVSISGFADSLKVRETHIPYLRFESKAYKILENNKEFQKIKKKIASKEDDRVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V2</accession>
    <name>C6X3V2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07090">
        <property type="protein sequence ID" value="ACU07090"/>
        <property type="gene ID" value="FIC_00635"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00635"/>
    <dbReference type="HOGENOM" id="CLU_3251862_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="42" mass="4601" checksum="462EA0891E9C69D5" modified="2009-09-22" version="1">MLAANVWPLTEVADERGLSSSAKIMFLREIATSGYRKLGNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X461</accession>
    <name>C6X461_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase Obg</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">obg</name>
        <name evidence="8" type="ordered locus">FIC_00744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782345.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00744"/>
    <dbReference type="EnsemblBacteria" id="ACU07199">
        <property type="protein sequence ID" value="ACU07199"/>
        <property type="gene ID" value="FIC_00744"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00744"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_3_10"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="7">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="160"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="307"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="327" mass="36028" checksum="0B5BF2F0360BDA34" modified="2009-09-22" version="1">MSNFVDYVKIHCKSGHGGAGSAHLRREKYIPKGGPDGGDGGRGGHVIMKGNAHEWTLLPLRFTRHIKAERGHNGQKNQLTGAYGDDVYINVPIGTIAKNEEGEVIAEILEDGQEIIIMHGGKGGLGNEHFKSSTNQTPRYAQPGLPGEEGFVTFELKLLADVGLVGFPNAGKSTLLAAVSAAKPKIADYAFTTLTPNLGIVDYRNYKSFVMADIPGIIEGAAEGKGLGHRFLRHIERNSILLFLIPADAEDYFQEFKILENELKEFNPELLDKDFILSISKADMLDEELKKEISKKFPENRQPIFFSSVTQEGLMELKDAIWKKLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4E4</accession>
    <name>C6X4E4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="9">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpA</name>
        <name evidence="13" type="ordered locus">FIC_00829</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782428.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00829"/>
    <dbReference type="EnsemblBacteria" id="ACU07282">
        <property type="protein sequence ID" value="ACU07282"/>
        <property type="gene ID" value="FIC_00829"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00829"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_10"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="12">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="10">
        <location>
            <begin position="151"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="11">
        <location>
            <begin position="396"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="525" mass="56410" checksum="F3233EC4F13FAC09" modified="2009-09-22" version="1">MAEINPAEVSAILKQQLANFDTQSNVEEVGTVLTIGDGIALVYGLENVQYGELVKFDSGIEGIVLNLAEDNVGVALLGESKMVKEGDTVNRTKRISSIKVGEGMLGRVVDTLGNPIDGKGPIGGELYEMPLERKAPGVIFRQPVTEPLQTGIVAIDSMIPVGRGQRELIIGDRQTGKTTVALDTILNQREFYDAGQPVFCIYVAVGQKASTVAQIVKTLEDKGAMPYTVVVAANASDPSPMQVYAPMAGAAIGEFFRDTGRPALIIYDDLSKQAVAYRELSLLLRRPPGREAYPGDVFYLHSRLLERSAKVIADDTIAAQMNDLPDTLRPIVKGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESDLFNSGVRPAINVGISVSRVGGNAQIKSMKKVSGTLKLDQAQYKELEAFAKFGSDLDASTQGVISKGERNVEILKQPVNSPLPVDSQVAMIYAGTENLLRNVPVKKVKEFQKEYVAFLRSKHPDTMAAIKSGKIDDGITGILKQAAIELASKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I1</accession>
    <name>C6X4I1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00866"/>
    <dbReference type="EnsemblBacteria" id="ACU07319">
        <property type="protein sequence ID" value="ACU07319"/>
        <property type="gene ID" value="FIC_00866"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00866"/>
    <dbReference type="HOGENOM" id="CLU_3365101_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="4226" checksum="A8F8AAD6D386F0F0" modified="2009-09-22" version="1">MITKYLRIFAPLFVDRFGEAKTLTINIFRIFQQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L4</accession>
    <name>C6X4L4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782498.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00900"/>
    <dbReference type="EnsemblBacteria" id="ACU07352">
        <property type="protein sequence ID" value="ACU07352"/>
        <property type="gene ID" value="FIC_00900"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00900"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_6_10"/>
    <dbReference type="OMA" id="EEMQLQC"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="29456" checksum="0D6D8AD05A4AC020" modified="2009-09-22" version="1">MEKYSDLKLFFWLGTATMALLAVAVILLALFYQRRLYKLKKSETFLRMRAILNKEKEERARISSELHDTVIGNLVSISIYFGMLKNRLKDPEVLGVISEIDEELKDTKQLIRQITYNLMPPLLYNSGFIASVEDFLRKSSTRYGFVYELHHFGFIEFSKQSSYDVLLILREFITNSCVHGGSKNIKITLSTTKNHNIITYTDNGKKYDFYRKIQSSTGYGLKNILSRVENLNGNLHQRESATQNEFVMFVKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L6</accession>
    <name>C6X4L6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782500.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00902"/>
    <dbReference type="EnsemblBacteria" id="ACU07354">
        <property type="protein sequence ID" value="ACU07354"/>
        <property type="gene ID" value="FIC_00902"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00902"/>
    <dbReference type="eggNOG" id="ENOG5033KQC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174020_0_0_10"/>
    <dbReference type="OrthoDB" id="1891165at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="102" mass="11306" checksum="8B9AC7978F81ABEC" modified="2009-09-22" version="1">MEFSTTSGEIISLEEARRYTHAFQKRYPHEKKAFFAGAENLRKILEQPGCLGIRIYNGYSEDEETSNKVLIGVDAEGNDITEGIIVEKLTACPPICTALPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P1</accession>
    <name>C6X4P1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, Gfo/Idh/MocA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782525.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00928"/>
    <dbReference type="EnsemblBacteria" id="ACU07379">
        <property type="protein sequence ID" value="ACU07379"/>
        <property type="gene ID" value="FIC_00928"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00928"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_10"/>
    <dbReference type="OMA" id="GWHHARV"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="320" mass="36340" checksum="3126887592A51403" modified="2009-09-22" version="1">MLRAGLVGAGHLGKIHLKLLNQSEKYELVGFHDADKENGKKLETEFGYTYFESFEALLAEIDMLDIVTPTLYHYDYAMQAIAHRKHFFIEKPVTQTLQQAEEIMFKCREFGIKSQVGHVERYNPAFIGSRNFIQNPMFIEIHRLAEFNPRGTDVSVVLDLMIHDLDILLSIVKSKVKAIHASGVAVVSKSPDICNARIEFENGCVANLTTSRISMKSMRKSRFFQKDAYISVDFLEKKAEVIRMKDAPENPTDFDMIIENAEGERNQIIFEYPNIQPNNAILDELESFASAISEDKNVEVSLEDGTEALKVALEIVRLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P6</accession>
    <name>C6X4P6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782530.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00933"/>
    <dbReference type="EnsemblBacteria" id="ACU07384">
        <property type="protein sequence ID" value="ACU07384"/>
        <property type="gene ID" value="FIC_00933"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00933"/>
    <dbReference type="eggNOG" id="ENOG5030K00">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1501376_0_0_10"/>
    <dbReference type="OMA" id="VMLKSNV"/>
    <dbReference type="OrthoDB" id="1914649at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="179" mass="20677" checksum="AE3DF524338CF8E4" modified="2009-09-22" version="1">MGRSEDKENKIQFLTRVTDNIMWWMGSIPSLIVHSIVFLTAFLLPIFGIVSVDKMLLVLTTVLSLEAIYLAIFIQMSVNRSQEHIEDIREDIEEIQDDIEEISEDIEEISEDIDDIQEDIEDIAEEEDEEDHSERARTVMLKSNVSSNKNDIKALREVIAKLQTELEMVKKEEGQNPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R8</accession>
    <name>C6X4R8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methylmalonyl-CoA mutase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782552.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00955"/>
    <dbReference type="EnsemblBacteria" id="ACU07406">
        <property type="protein sequence ID" value="ACU07406"/>
        <property type="gene ID" value="FIC_00955"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00955"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_6_1_10"/>
    <dbReference type="OrthoDB" id="720283at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="138"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="388" mass="43950" checksum="138F4F30B159F73E" modified="2009-09-22" version="1">MFNKTSLQDWEALVQKQLKTDDIYSVLSKENLEQISVKPYYGSAPKSLPNLPKIEESTQLVSRYSEDLEEDVFAFLLDTNVENLVEKVIFVNNKDLAEHILVDETNRYISLVDVFSDDQHGVIDEQLAKELLAKNFGRNICIDVSLHQNAGASISQQLAFALGKTKDLTELFGSEILKNLSFRFAVGANYFFEIAKLRAFKLLFNQFSKEFGLDEFPYIFAETSLRNKSKSDPENNLIRSTLELSAAMLGGADAVFSHDFRIGAETSLSEEISFKQQIVLAYESIINVFDDAGNGSYYVEDITRQLAEKAWALFLEVEEKGGYAENLRTGNIQKMISEHAVEEQNWVAEGKIKLIGVNLYPKHEITKNVEAMYDPAVIKPVRLSEMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4X0</accession>
    <name>C6X4X0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782604.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01008"/>
    <dbReference type="EnsemblBacteria" id="ACU07458">
        <property type="protein sequence ID" value="ACU07458"/>
        <property type="gene ID" value="FIC_01008"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01008"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_9_10"/>
    <dbReference type="OMA" id="IIFIDIM"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="120" mass="13699" checksum="95709DE4F45E5423" modified="2009-09-22" version="1">MKKILIADDEHKIIMTLEYAFRKAGYEVYIARDGAEVLEIIKTEIPDIILLDIMMPNVDGYTTLSEIRKDKSYENIKVVFLSAKTGEADIKKGLERGADAYVTKPYSIKKLTEKVEKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X521</accession>
    <name>C6X521_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01059"/>
    <dbReference type="EnsemblBacteria" id="ACU07509">
        <property type="protein sequence ID" value="ACU07509"/>
        <property type="gene ID" value="FIC_01059"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01059"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050037_0_0_10"/>
    <dbReference type="OMA" id="KYANNYD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008670">
        <property type="entry name" value="CoA_reduct_LuxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05893">
        <property type="entry name" value="LuxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="355" mass="40839" checksum="848EAC4FCD20346C" modified="2009-09-22" version="1">MRTFAQPNFRLMNRDLQITGLCRLSVYIKNFLQKDPADFDADDQQFQSVLLKSETENPWFTPENQRFALNQWANLLTQEKLGNWLAAYSVAKQPKRVGLILAGNIPMVGFHDVISVVLSNHIPVIKLSSKDRLLLPFLLEKWNDLSEGAVRFETVERLQNFDAVIATGSNNTARYLEFYFKNHLSIIRKNRTSVAVLSGNESDAELQLLAQDIFRYFGLGCRNVTRILIPEDFLVDRLFENFIAFKGVINHNKYANNYEYNRAIYLLNQEKFWDNNFVMLKEDENLFSPLSVINISRYSDIAEVQKFISENTLDIQAIVAKEELGLASVGFGEAQNPALDTYADHVDTMRFLEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X541</accession>
    <name>C6X541_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805814.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01079"/>
    <dbReference type="EnsemblBacteria" id="ACU07529">
        <property type="protein sequence ID" value="ACU07529"/>
        <property type="gene ID" value="FIC_01079"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01079"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_11_10"/>
    <dbReference type="OMA" id="DEGVMTF"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="203"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="306" mass="35919" checksum="5D925137A4A15698" modified="2009-09-22" version="1">MKEPVHKPYIIHSISDLHRLLELPKPKHPLVSVIRFEEIKCFDDEMLRTVSYNFYCIAIKKNFDGKMKYGQQYYDFDEGVMTFFSPKQVITTDIVEDLKLSGYWLVIHPDFIRNYPLGKAIKNYGYFSYAVNEALHLSEDEEKSVIAIMQNIENEYRSVIDNFSQDVMVSQIEVLLHYCNRYYNRQFITRRTAGNGLLIKLEELLAECFEEDRLQNTGLPSVQYLSDQLNISADYLSDMLRNLTGQNTQQHIHNHLIEKAKDLLITTNLTVGEIAFQFGFEYPQSFSKLFKQKTNQTPLEFRQAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X544</accession>
    <name>C6X544_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01082"/>
    <dbReference type="EnsemblBacteria" id="ACU07532">
        <property type="protein sequence ID" value="ACU07532"/>
        <property type="gene ID" value="FIC_01082"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01082"/>
    <dbReference type="HOGENOM" id="CLU_3216569_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="44" mass="4820" checksum="0E0ECC0B534939E4" modified="2009-09-22" version="1">MIPERSANPGNLENVSDTCKFFTGNCEGGWQPASQFTLQTEVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X567</accession>
    <name>C6X567_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane protein, probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805840.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01105"/>
    <dbReference type="EnsemblBacteria" id="ACU07555">
        <property type="protein sequence ID" value="ACU07555"/>
        <property type="gene ID" value="FIC_01105"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01105"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OMA" id="QSWIIEP"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973706" evidence="5">
        <location>
            <begin position="27"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="119"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="409"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1001" mass="109343" checksum="3B1C33477AE398D1" modified="2009-09-22" version="1">MKKKFCRPAGIAFAFLLSGVYTTVHAQSRTVTGTVNDGDKPLSGVTVSQEGSSQMTTTTASGAFSLQASGENPVLVFRHPEYGERKIVADRSSFVVSLTEKVNTIQEVVLNAGYYAVNARESTGSIAKVTAKEIENQPVTNVLSAVQGRMAGVSITQNSGTPGGGFDVQIRGRNSLRNLLNSMTDGNAPLYIIDGVPLAGDLISTLSTSALPLQRISPLNSINPNDVESIEVLKDADATAIYGSRGGNGVILITTKKGKASPVRLKVNSSQGFSQVGSVLKMMNSAEYISMRKQAYANVGTTVYPANAYDINGTWDQTRYTDWQKELLGGTAENTNILVNVSGGSDRNSFSVSAGYGNQTSVFPGGQQYRTNTLSSHFDHHSADRKFSLGFSNLLTLTKNRTLNTDFTNAALRLAPNAPALFDTAGNLNWENGSFNNPLAQLNARYRNATQHVNQNLNIAYRFWGGFSAKLNAGATLQQLEEYSLLPNTIYSPSSGLHSSSAYSSSSRGTSSVFSYLLEPQLTWTKKYDAHEWSVLTGVTFQESVNKNSGMNGYGYASNSLLENIAAATNVTVLPLEENQYRYAAFFGRTNYQFKNRYILNLTARRDGSSRFGPNRRFASFGAAGAAWVLSEESFLKDFSWLSFAKLRGSIGRTGSDAIGDFQFLNTYSIGYYAYDGLPGLYPSRLYNPDFSWEKTDKLEAALDVSVFNDRIALTAAWYRNRSSNQLVGIPLPSTTGFSSILANLGATVENSGFELELGVHPLKGSAWEWSSSFNISIPRNKLLAFPGLEGSTYANRYVVGESIYVVKLLDYNGINAEGQYTFTDFNGDGKISSPDDSKALRTLGPKYFGGFQNTVRYRDFSLAFLVQFVKQQGWNYFRTMATPGLMVNQPVDLLNVWSPTNPGGIIMPYTPGNDSLTNTLSDHFMNSTAAVSDASFIRLKNIQLNYAVPLQNTLIKEAHIYVQGQNMLTWTNYFGLDPEFVTSGFLPPLKTLSMGLQLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5N8</accession>
    <name>C6X5N8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-like beta Propeller</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806011.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01278"/>
    <dbReference type="EnsemblBacteria" id="ACU07726">
        <property type="protein sequence ID" value="ACU07726"/>
        <property type="gene ID" value="FIC_01278"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01278"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014266_0_0_10"/>
    <dbReference type="OMA" id="TTCGWIH"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="431"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="662"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="741" mass="81676" checksum="B0C6D57952381544" modified="2009-09-22" version="1">MNKSRTVSAIALLGIFVGLSAQENNLRNIRKLTFGGDNAEAYFSPDSKKLTLQVTNPEIGAQCDQIYLLDLTKKDTSVGDLKLISTGDGRTTCSFFMPDGKHILYASTHEASKACPEKPKPRTDGKYLWPVYEEFDIYIADLNGKITRKLTDSPGYDAEAVVSPDGKYIVFTSMRSGDLELWRMDIDGKNLKQLTTGLGYDGGAFFSHDSKKLVFRSSRPTSEKEVKEYRELLGENLVAPTNMEIYTMNVDGSDLKQVTNLGKANWSPYFHPSDRKIVFSSNHHSTRGYDFQIYSIDTDGRNLTQITYESEFNAFPMFSPDGKQLVFSSNRQAGKAHETNVFVADWVESDAKQTVSEENLQRSVSYLASDDLKGRLAGSDGEKKAAEYIANAFRQLKLKPLEGNGYVQNFSYDLKLNPHAADSSAKIDGRNVIGYLDNKAGKTVVIGAHYDHLGLNEHHNSTLANSGGQIHNGADDNASGVAAVLELARIFSQNGTKEQANYIFALFSGEEDGLIGSKKFAESVKIKYPNVVTMINLDMIGRLNKDKDLTVGGVGTSPIFGELIRKYKPAGFNLAVDSSGVGPSDHTSFYLKDIPVLFLFTGTHEDYHKPSDDTDKINFPALKIITNYVFNLANELSKTTDIPFTKTKNTMSKEVPQYKVTLGIMPSYADTTDGLHIDGVSENRPAANAGILAGDILTRIGTCEVKEVYSYMDCLSKVNSGDEMPVTVIRDGKPITLTVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5R9</accession>
    <name>C6X5R9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III subunits gamma and tau</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806042.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01309"/>
    <dbReference type="EnsemblBacteria" id="ACU07757">
        <property type="protein sequence ID" value="ACU07757"/>
        <property type="gene ID" value="FIC_01309"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01309"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_2_10"/>
    <dbReference type="OMA" id="YHIERNG"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="372" mass="43076" checksum="1575264D58A18DEE" modified="2009-09-22" version="1">MNWDQIVGQKKIKHLLTESISDNRVGHAQLFLGADGYGTLALAMAFAKEILKKENEHSCSKVAHLNHLDLHFSFPVFKEKSSGLSSNFAEEFREMVLNNPYSDNEDWSRILESENKQLTIYADEIDQVNQKFALKSFEGGSKILIVWQADKMNISAANKFLKFLEEPPKDTFIILTAENGDSILPTILSRTQLVEIPRIDDKDIEEFLKKTYDISEEKISEIVFQAQGNWNTAQKLMLSDDSDDEFEKLFVLWVREAFQVKKKPQFLKNIVLWGRNIAVWNREKQKNFLHYCAEMFRLALLQNYGNENLVYKKIDSGGFRWDSFSKYIHGANIEAILNEISEADYHLERNANPKIVWTDLGIKLSRYIHKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S7</accession>
    <name>C6X5S7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable Co/Zn/Cd efflux system membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806050.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01317"/>
    <dbReference type="EnsemblBacteria" id="ACU07765">
        <property type="protein sequence ID" value="ACU07765"/>
        <property type="gene ID" value="FIC_01317"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01317"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_2_10"/>
    <dbReference type="OMA" id="SVIKLDF"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="69"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="351" mass="37441" checksum="890C926F81438A18" modified="2009-09-22" version="1">MKKRTLITILVIVAVAAGFFFILENNKKKNEEQVAIVAEKNTNVAVRTVPVKREEISGEFAVNGTFLPNRQSQISAEIGGQLIALYVKEGSYVRAGQSIGRLGGEKLNVNVGNAQANLSQAQSALSRYEAAYKTGGVTALQLDQARLQVQNARSQVQSANLQSGDTNIISKISGIVNQKMLEVGAVVNPGTPIVEIVDISSVKLKVDVDQALVSQLAVGNTVKVKPDVVEGTIDGRITFIAPSASGALKFPVEITIPNSFNKLKAGMYGTATFNRTGVNNVLTVPRDAFVGSVSDNRIFVVKNNVAYLTQVQTGINYGDKVEIVSGLNEGDLVVTSGQINLADKTKVQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U8</accession>
    <name>C6X5U8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806071.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01338"/>
    <dbReference type="MEROPS" id="S09.021"/>
    <dbReference type="EnsemblBacteria" id="ACU07786">
        <property type="protein sequence ID" value="ACU07786"/>
        <property type="gene ID" value="FIC_01338"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01338"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017120_0_0_10"/>
    <dbReference type="OMA" id="FPIQSER"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973728" description="Peptidase_S9 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="646"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="800" mass="90034" checksum="0A1F3B77563750DE" modified="2009-09-22" version="1">MRIKSAAVALLFVGFTYAQENITYQQPSAEILQLADFQRAPSVMMNSKKDWMVFSYRATYKSLDELNQPEMKLAGLRVNPVTNIASTVTYVNNLKIRKLKDKSETQVKGLPANPKISFTVFSPDEKKMAFTNTTAKGVELWVLDLATATAKKISSDNLNANLGMPYVWMKDSESLLVKRIPANRNALIDSKTEIPTGPTVSNSDGKVSQNRTYQDLLKNPQDEANFETLAKSELVKVTLNGEQQDYKTSAIYSGMSFSPDGNYLMLTTIQRPYSYIVPLNRFPMNSEVYDFNGNLVKTVNEVPLTEIMPKGFSSTRPGKRSMSWRDDQPATLVYAEALDGGDQAKTVENRDEIYLWEAPFTEAPKSFFKTKQRFSGIDWSNGGFAIVSDSWYDTRNTKSYLIDLKTNSSKLIEDRNYQDVYQDPGTFNTTKNQFGRTVIDAKNNKAYLVGEGFTKNGQYPFIDEIDVNSLSKKRIYTSKLKDSKESIIDILDAKAGSVLVVEQSPNLYPNYFIRNIKNGKATALTSFANPFASIKDVYKEVIKYKRNDGVELTGTLYLPAGFDRKTPKEKLPLLIWAYPTEYKDKNTAGQITQNPNDFTFPSYGSFIYWVNKGYAVLDDASFPIIGEGKTEPNDTFLPQLVANGKAAIDAVDALGYIDRKKVAVGGHSYGAFMTANLLSHSKDYACGIARSGAYNRTLTPFGFQAEQRNYWDVPEIYNTMSPFMNADKMKTPMLLIHGEADNNPGTFTLQTERYFQALKNLGAPVRMVLLPLESHGYAARENILHVLWEQDQFLEKCLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5U9</accession>
    <name>C6X5U9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806072.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01339"/>
    <dbReference type="EnsemblBacteria" id="ACU07787">
        <property type="protein sequence ID" value="ACU07787"/>
        <property type="gene ID" value="FIC_01339"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01339"/>
    <dbReference type="eggNOG" id="ENOG5032YX9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126586_1_0_10"/>
    <dbReference type="OMA" id="NSHQEVN"/>
    <dbReference type="OrthoDB" id="1866745at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="18747" checksum="CD28609E623EF9AD" modified="2009-09-22" version="1">MKNIILSALSVFFILSCDKKSTEITDLESTATDSVVVPETNEPVESSTLQTCYVAVSGKDSVFVSLDDNLGTIIGKMRYKNFEKDSSFGDVSGTQNGDTLKLNYVFQAEGTTSDREIYFLRKDGNLIEGIGEHNVDADKDTYADAGKLKFEGHTLKPVDCTDFDKKFVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X656</accession>
    <name>C6X656_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, TerC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01446"/>
    <dbReference type="EnsemblBacteria" id="ACU07894">
        <property type="protein sequence ID" value="ACU07894"/>
        <property type="gene ID" value="FIC_01446"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01446"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_10"/>
    <dbReference type="OMA" id="ADHAREY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="369" mass="42029" checksum="13C46B952F23351E" modified="2009-09-22" version="1">MRLFFYMNSETYFLLGFLAFIVFILALDLGLLKKKSDTVSMKQAGLMSFFVVALSMCFYFVLITYGHLLHGIDSMEKLQSVISSHHHPVKIIPGDLGNSIQLYNQNLGLEYLTGYVVEYALSIDNIFVMVLVFTAFGVAPKNYHRVLFWGILGAIVMRFIFIFVGAALIEKFSWIMYVFGAFLVFTGIKMFFDKDGGDKIDTQNHPVVRFANRFFKVHNHFVGNKFFVTIDGVKKITPLFLVLLIIEATDLIFAVDSIPAIFSVTKDPYIVFFSNIFAIIGLRSMFFLLAGIIDKFRFLKVGLSVLLTFIGLKMLAHSYLDTWGFTTGHSLIIIVGILGASIMFSLIFPKQEKERKLKFDPKNDEHLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6A4</accession>
    <name>C6X6A4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpD</name>
        <name evidence="6" type="ordered locus">FIC_01495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806227.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01495"/>
    <dbReference type="EnsemblBacteria" id="ACU07942">
        <property type="protein sequence ID" value="ACU07942"/>
        <property type="gene ID" value="FIC_01495"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01495"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_10"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="72"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="107"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="328" mass="35919" checksum="29E3512D863EC2AE" modified="2009-09-22" version="1">MKQILQYLFNHNTLSKAEAKAILTEIAQNKFNENEVTSFVTVFLMRAITLEEMEGFQEALLRLAVPVDLGTDDLVDIVGTGGDGKDTFNISTLASFVVAGAGQKVAKHGNYGVTSVSGSSNVLEELGYQFKTNSEDLQKDLAKGNICFLHAPLFHPALRAVAPLRKGLGLRTFFNILGPLVNPAKPKFPMIGVYSLEIARIYQYLLQKKHENFLLVHALDGYDEISLTSDTKIFEPEGEFIYSAEELGFRNISPEAIFGGNSKQEAAVIFKTILEGKGSYEQNSVVLANAAMALKNTGKFGGYENCLTLAKNSLENGHALRCLNNIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B2</accession>
    <name>C6X6B2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator (Contains diacylglycerol kinase catalytic domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806235.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01503"/>
    <dbReference type="EnsemblBacteria" id="ACU07950">
        <property type="protein sequence ID" value="ACU07950"/>
        <property type="gene ID" value="FIC_01503"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01503"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_1_2_10"/>
    <dbReference type="OMA" id="VNSCVGG"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="283" mass="32084" checksum="6FAA30C7CEB775A6" modified="2009-09-22" version="1">MNNVAFIINPFSAKKNYEPFFEALKKRIDQPVVYISDSVQGTFDFIDSNFAQIDIFVAVGGDGTISTVARKIIGTDKILAVFPAGSGNGFSNETKFTRNLEDLLSKIKNKKVKKIDTFTVNGRLSINVSGTGFDGKVVKEFEKTSRGFRNYIQVSMRTFINYKPIKVNFLTENLKSYNGEYLMLNIANTRQFGNHAYIAPHASKSDGLLDIVLVKKFPLQYAVRFAYRMFTKKLKDDEFVTYLPVAEVEFEVNTTNWHLDGEFHRIESPVKIKIAPKSLNILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6D0</accession>
    <name>C6X6D0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806253.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01521"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07968">
        <property type="protein sequence ID" value="ACU07968"/>
        <property type="gene ID" value="FIC_01521"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01521"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_10"/>
    <dbReference type="OMA" id="TLITDWD"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973504" evidence="4">
        <location>
            <begin position="19"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="5">
        <location>
            <begin position="694"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="775" mass="84820" checksum="859BFE69AEC7A2E9" modified="2009-09-22" version="1">MKKLVLVAAMALSPCIAAQEMVSKPVQSYRTEQYKTKKQAFVNALLAKMTVDEKIGQLNLPSAGDFTTGQAQSSDIGKKIEDGLVGGLFNIKGAEKIHAVQKVAVEKSRLKIPLIFGMDVIHGYETSFPIPLGLAASWDMNLIQQSARVAANEASADGISWTFSPMTDISREPRWGRISEGSGEDPYLGSEVAKAMVYGYQGKDMSLSNTIMACVKHFALYGAGEAGMDYNTVDMSHVRMFNEYFPPYKAAVDAGVGSVMASFNEVDGIPATGNRWLQTEVLRNQWGFDGFVVTDYTGINEMIDHGVGDLQQVSAMALKGGIDMDMVGEGFLKTLKKSLEEGKVTQAEIDQAAKRVLEAKYDLGLFDDPYRYGSAKLAEKEVYSQKNRDIARNAAANSMVLMKNDNSVLPLKKGGTVAVIGPLVNNALNMAGTWSVAAKHINAIPLMKGLQDTFGKGTKFISAKGANIDYSEKLENIYAAHGKLTDRDNRPKETLLKEATDAANKADVIVLAIGESAEMSGESSSRTEIDIPQSQVDLLMELKKTGKPIVMVLFTGRPLALTNVKDIPDAILNVWFAGSEAGHAIADVLYGKVNPSGKLPVTFPRSLGQVPIYYNHKNTGRPLNADKTGKCEYERFRANYMDECNTPLYPFGYGLSYTKFTYSDIAVSNPKPQGNQAIQASITLTNAGNYDGAEVVQLYIRDLVGTITRPVKELKGFQKVFLKKGESRKITFNITPEDLKFYNNALKYDWEPGEFEVMIGTSSSDVQRTKINWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6E2</accession>
    <name>C6X6E2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806265.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01533"/>
    <dbReference type="EnsemblBacteria" id="ACU07980">
        <property type="protein sequence ID" value="ACU07980"/>
        <property type="gene ID" value="FIC_01533"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01533"/>
    <dbReference type="eggNOG" id="ENOG502Z9ZK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078172_0_0_10"/>
    <dbReference type="OMA" id="YIYRNKD"/>
    <dbReference type="OrthoDB" id="1264224at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973750" evidence="1">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="29852" checksum="912D8173B8662E9F" modified="2009-09-22" version="1">MKIFTIIFFSLFCSLSAQRTVDAEFLNLHDADHLFADDYGNIYIYRNKDFSFTKYDSLGTQRGKLMFTLPFKIQSVQNPLNIPAFSENAQEIRFYDQNLNERQKLDFSQKFGFIKMAYAEDQQTIWLLEESTKRLLQYNFREDRLINSFPFNIGFEDITDLIVYENTAYILTKNAVTSYNFQTQKLFEIPLANPLKLRRDNGNILVVQQHKVSVIRNDSLKTLLQADEAQIVDKNSASYFEIRGNKLYLYPINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F5</accession>
    <name>C6X6F5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein CspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806278.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01546"/>
    <dbReference type="EnsemblBacteria" id="ACU07993">
        <property type="protein sequence ID" value="ACU07993"/>
        <property type="gene ID" value="FIC_01546"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01546"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_7_2_10"/>
    <dbReference type="OMA" id="TEEIFVH"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="63" mass="6960" checksum="ECD5FC910B75FFAA" modified="2009-09-22" version="1">MQEGTVKFFNETKGFGFITPLNGGEDIFVHTSGVNTKIRENDKVTYEVQQGNKGLNAVNVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6F9</accession>
    <name>C6X6F9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806282.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01550"/>
    <dbReference type="EnsemblBacteria" id="ACU07997">
        <property type="protein sequence ID" value="ACU07997"/>
        <property type="gene ID" value="FIC_01550"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01550"/>
    <dbReference type="HOGENOM" id="CLU_2522657_0_0_10"/>
    <dbReference type="OrthoDB" id="2035611at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="84" mass="9951" checksum="A57D8C8381D5CFD4" modified="2009-09-22" version="1">MSENILSVEDLKFLERLHSHYGLEFIRFDDSGIKLNNQDLLDDDIAKTDYFNLLTEISKKLKYRLNSNFQMNFTTSFNLDVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H2</accession>
    <name>C6X6H2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent exoDNAse (Exonuclease V) alpha subunit-helicase superfamily I member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01563"/>
    <dbReference type="EnsemblBacteria" id="ACU08010">
        <property type="protein sequence ID" value="ACU08010"/>
        <property type="gene ID" value="FIC_01563"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01563"/>
    <dbReference type="eggNOG" id="ENOG502ZB4S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073797_0_0_10"/>
    <dbReference type="OMA" id="FRIHYGI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="30098" checksum="1ECBE97569A3D8B1" modified="2009-09-22" version="1">MWQIICKTKHMNKFFGFLGILFFALGFSQKLDNIQSGESLNYRIHYGLLNAGSATLSTSKTTYKGQPHLHVKGYGKTTGAVRAFFKVEDFYESYINSKTGLPSFYVRNVKEGGYTQHLQTSFNHNNQTLLLTDKEKNTTQTMKSVKGVQDMLSAFYYLRSLEASDLRVGSVKKLNVWIDDEFFPFQLKVIGTENVKTKFGTINCLKIVPQVISGRVFKDKEGVTLWVSNDRNYVPIAIKAELAVGSLKASIDSYKNVKYPMKFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H5</accession>
    <name>C6X6H5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806298.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01566"/>
    <dbReference type="EnsemblBacteria" id="ACU08013">
        <property type="protein sequence ID" value="ACU08013"/>
        <property type="gene ID" value="FIC_01566"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01566"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_10"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="191" mass="21595" checksum="E1BA18F98148235C" modified="2009-09-22" version="1">MAREILIATHNQHKKEEIQQILGEDFHVDSLTDYDIHDEIVEDGDSFHENALIKAKYCFEKTGKPSVGDDSGLVVEALDGRPGIYSARYAGDHDFAKNMAKVLDELKETENRNAYFVTVMCHVDGAGEHYFEGRVYGQLTREIRGAKGFGYDPIFIPDGHDITFAEMKAEDKNKISHRSQALEKLLAFLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6J1</accession>
    <name>C6X6J1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01582"/>
    <dbReference type="EnsemblBacteria" id="ACU08029">
        <property type="protein sequence ID" value="ACU08029"/>
        <property type="gene ID" value="FIC_01582"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01582"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_1_10"/>
    <dbReference type="OMA" id="QGAYYIT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="268"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="373"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="501"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="586" mass="63919" checksum="A844028B6824D7C1" modified="2009-09-22" version="1">MKIEQIYTGCLAQGAYYITSNGEAAIIDPLRETQPYIERLEKDGVALKFIFETHFHADFVSGHLDLSEKTGAPIVYGPTAEPEFESIIAEDGQIFAVGDVKIKVLHTPGHTMESSCFLLIDEKGNETALFSGDTLFLGDVGRPDLAQKAAHLTQEELAGLLYESLSNKILPLADDITVYPAHGAGSACGKNMQKETVDTLGNQKQTNYALNQPNKEAFINAVTDGLLPPPAYFGMNVAMNKKGYDSFQDVKRSGMTAFSPDDFETAAENTGALILDTRNNADFAKGFIPQSVNIGLNGDFAPWVGTMIVDVNQPILLVTEEGQEEEAITRLSRVGFDKIAGHLAGGFSAWKDSGKSTDTVNRITAAQFASEVKIGENTIVDVRKESEYAAQHVEDAYSKPLAYINNWITDIDPQQHFYLHCAGGYRSMIAASILQARGYRNFTEVEGGFAAIAKTEVPTTDFICQSKVLSSNPQFNNRKTMFNFLKNIFTPPDNSALGDIINSGAFLVDVRTPGEFRSGSVKGAVNIPLDVITKHLGKFAGKKNTVVFCRSGNRSGQAKRILEQNGISNVSDGRTWQNVNHLLNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZB9</accession>
    <name>C6WZB9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00495"/>
    <dbReference type="EnsemblBacteria" id="ACU06953">
        <property type="protein sequence ID" value="ACU06953"/>
        <property type="gene ID" value="FIC_00495"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00495"/>
    <dbReference type="eggNOG" id="COG0252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_2_2_10"/>
    <dbReference type="OMA" id="AIVPKLM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="6">
        <location>
            <begin position="265"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="387" mass="44302" checksum="45E44AED4B7682DA" modified="2009-09-22" version="1">MFLFNILCLNAVTAPRLERSSPPRRKREWKTETGAQIICHIFKYRIFEFMKRKVLLIYTGGTIGMEKDYDTGSLRAFDFGNIFDKMPEMNLIECEITVHPFKKPLDSSDMGPKEWKIIANYIGKNYEDYDGFLILHGTDTMSYTASALSFMLKNLRKPVILTGSQLPIGDLRTDAKENLLTSLYYASLYENDEAVIQEVTVYFEYKLLRGNRTLKYSAEYFDAYQSPNYPTLGQSGVHLNIEKDFLYRPKQDEEFSVDDHISRDVLFWRIFPGMHLDHFEEIPKMKVLILQVFGSGTIFNTRHTQQTLQLLRERGTEIVVVSQCVSGGVSFGKYSNSNIFNEIGAVSGHDMTAESAITKAMHLLDNPNYDGSFAENFAKNLCGEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD4</accession>
    <name>C6WZD4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alaS</name>
        <name evidence="12" type="ordered locus">FIC_00507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782112.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00507"/>
    <dbReference type="EnsemblBacteria" id="ACU06965">
        <property type="protein sequence ID" value="ACU06965"/>
        <property type="gene ID" value="FIC_00507"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00507"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_10"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="11">
        <location>
            <begin position="1"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="749"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU06965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="893" mass="100400" checksum="1C3C384CCE1D2603" modified="2009-09-22" version="1">MTSQQIRQQFLDYFQSKGHLIVPSAPIVLKDDPTLMFSNSGMTQFKDYFLGYKDPKAPRIADTQKCLRVSGKHNDLDDVGRDTYHHTMFEMLGNWSFGDYFKEEAIGFAWELLTEVYKIPKEDLYVTVFEGDSVEDLARDQDAYNFWKKHIDEGRIINGNKKDNFWEMGESGPCGPCSEIHVDLRTAEEKGMVSALDLVNNDHPQVVEIWNLVFMEFNRKADGSLEKLPAQHVDTGMGFERLCMALQGKTSNYDTDVFTPLIQKVEEISGLRYTGILTDEKDIAIRVVVDHIRAVAFAIADGQLPSNGGAGYVIRRILRRAISYAYRFLGMKEAFLFELVGVLQTEMGSYFAELSRQQKLVTEVIKEEEISFLKTIELGLKRIDLVINDTISKNEKTLPGAAVFELYDTYGFPADLSRIIAEEQQLTIDEAGFNEEMAKQKQRSKKSSAQKVYDWVILEEKEQQFVGYDDTETETYITRYRKVENKDGEYYQIVLSKSPFYPEGGGQVGDHGILVPSYAKNFNIVSPQKFLDQLASENNSDRPSEVIEVLDTRKENNLIISLIKEMPKDAGAVFYAKVNRDERRNTQANHSVTHLLHEALREVLGTHVEQKGSFVGPEYLRFDFSHFAKLTDEELKLVEEKVNTKIKENISLEEFRNIPISEAMEKGAMALFGEKYGDNVRMIQFGTSRELCGGTHVRNTAEIGFFKIQSESSTAAGIRRIEAIAGDQATAYFNNLESQFKEISALLKTKDISKTVEKLLEENAALKSEIEAFKKEKAKAETGNWKNDFTESAGKKLLVKKVSLDSASVKDIVFQLKKEVAGSVIIIISDADGKPMITVGVSADLETQYHAGNIVKELAKEIQGGGGGNPGFATAGGKNLAGIDEAYNKALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZF8</accession>
    <name>C6WZF8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00015"/>
    <dbReference type="EnsemblBacteria" id="ACU06493">
        <property type="protein sequence ID" value="ACU06493"/>
        <property type="gene ID" value="FIC_00015"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00015"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_10"/>
    <dbReference type="OMA" id="MCGLIKR"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="187" mass="21452" checksum="DA59C4412731F7DA" modified="2009-09-22" version="1">MNLKRTAMQQLNTVETERLTLKAISEADADLIFRLYNEPKFIEFIGDRNIGSPEDARKYIIARFLPLAQKLGFGNYVIFRKLDHEKLGAVGIFERDGLDVYDIGFSLLPEFENKGYAFEAAKALLDAAFSKLGIHRISAITTHNNFSSQKLIEKLGLKYIKTVRLPNDTEELRYYEIQDQSIKKETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG6</accession>
    <name>C6WZG6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06501">
        <property type="protein sequence ID" value="ACU06501"/>
        <property type="gene ID" value="FIC_00023"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00023"/>
    <dbReference type="HOGENOM" id="CLU_2273225_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973406" evidence="2">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="102" mass="10819" checksum="76513268978DCC0A" modified="2009-09-22" version="1">MKKSLIAIVFLVAGAVMVNAQTTQKTTKATKESVKANVPAVSTNASAELRTDTLTPNAPAVQSVDTAATIKIDRDSALKAEATDLKQNEATRKTEAKKFESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG7</accession>
    <name>C6WZG7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781649.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00024"/>
    <dbReference type="EnsemblBacteria" id="ACU06502">
        <property type="protein sequence ID" value="ACU06502"/>
        <property type="gene ID" value="FIC_00024"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00024"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_10"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="207"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="452" mass="49576" checksum="53159361527F5FE6" modified="2009-09-22" version="1">MEHFNAEQKIQDFIAKIEARNPNEPEFLQAVKEVAITVIPFISTKKQYNGMKLLERMAEPERTIIFRVPWVDDKGEIQVNRGFRIQMNSAIGPYKGGIRFHPTVNLSVLKFLAFEQTFKNSLTTLPMGGGKGGADFDPQGKSDMEVMRFCQAYMTELCKHIGPETDVPAGDIGVGAREIGYLFGQYKKIRNQFTGVLTGKGLAYGGSLIRPEATGYGVVYFAEQMLKTIGQDFQGKTVSVSGFGNVAWGVVKKVTELGGKVVTISGPDGYVYDKDGITGDKIEYLLELRASGNNRAEDYVKKFPTAEFHAGKRPWEVPCDVAIPAATQNELFVEDAKVLVDNGVICVTEAANMPSTLEAINYFLDHKVLFSPGKASNAGGVATSGLEMTQNSIRLNWSSEEVDARLKEIMIGIHKACRDYGKEEDGYVNYVKGANIAGFVKVAEAMLAQGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZH9</accession>
    <name>C6WZH9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system sensor histidine kinase/met hyl-esterase/transferase hybrid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781661.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00036"/>
    <dbReference type="EnsemblBacteria" id="ACU06514">
        <property type="protein sequence ID" value="ACU06514"/>
        <property type="gene ID" value="FIC_00036"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00036"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387250_0_0_10"/>
    <dbReference type="OMA" id="DEFRIVW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="343"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="396"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="470"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="526"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="747" mass="86299" checksum="A1676F274997B030" modified="2009-09-22" version="1">MEASFPPSFSVKEHVFGTILQKAQFGFALVNSSYVIEYTNQTWLEIIGLNKKTAVGKKIFDFFPEAADQLTAFFEETKETREPASAADFKLRIKRSGSVQPAYFSFMYQPVYEDNGAFLYYAVVILEISALVTIKYKMREDEERLRLATESSLTATWDLNLKTREIVHSPLLAKIFGYEAGENISHEQFRSHLFEYDRINIVDVAYKKALKTGIYKYEARITDRNGVQKWISTNGKIFSDENELPDRMLGILQDITERKKNEIRQHQSHHQLNTAMEATKLGLFDMNPETLEKYNFSPRFLEIFGYDPSSETIDTHVFEKHIHKDFIDVRAQALQKAQETGDLHYQTKIVLRDGSVKWIELYGRLLRESAASNAYISGTVRDITDLKNYEQKLSASEKKYRFLADVMPQIVWTGEPDGRLTYFNQSTLNYSGKSYKELLEGDGLNQMVHPEEQEETGKRWAASVRTKKPFFFEHRFRDSNNEYRWFMSKAFPEMDDAGNVTKWVGTSTDIDDMKRQEQQKDDFIKMASHELKTPVTTIKGYVQLLKRTRKDSDDKFLVNSLNTIENQVNNLSVLIGDLLDISRMENGYLLLNKHKFSLVELVTESIEDIKASEQSHEINFEMKHFADIEVFADKERLKQVLTNLLTNAIKYSPKANSVNVELWVEDGRGIVSVEDFGIGMEASELGKIFERFYRVSGDDEKTFPGFGIGLYIVKDIIQRLDGKIWVESEKNQGSKFYFSLPVSNKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR3</accession>
    <name>C6WZR3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system involved in resistance to organic solvents, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781745.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00123"/>
    <dbReference type="EnsemblBacteria" id="ACU06598">
        <property type="protein sequence ID" value="ACU06598"/>
        <property type="gene ID" value="FIC_00123"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00123"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_10"/>
    <dbReference type="OMA" id="NYLVFPK"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="250" mass="27319" checksum="46446A07B005B0EF" modified="2009-09-22" version="1">MFKNLLSQIGAYFLLLSKTMKRPQKSSVFGKLFMREIHDLGVNSFGLVLFTSTFVGAVVAIQMFNNFSASSFPIPNSFIGYATKVVLILEFAPTIISVILAGKVGSYIASSIGTMRVTEQIDALDIMGVNSPNFLILPKILASIIFNPLLIAISIVFGIWGGYLAGIATGSWSKADYITGIQMYMPQHFIWYAFFKTAVFAFLIATVPAYFGYNVKGGSLEVGRASTQAVVWTIVAIIITNLILTQMFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZR5</accession>
    <name>C6WZR5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="7" type="ordered locus">FIC_00125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781747.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00125"/>
    <dbReference type="EnsemblBacteria" id="ACU06600">
        <property type="protein sequence ID" value="ACU06600"/>
        <property type="gene ID" value="FIC_00125"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00125"/>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066739_0_1_10"/>
    <dbReference type="OMA" id="CDVKESW"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="210" mass="23655" checksum="07F0B369F1E8AFA9" modified="2009-09-22" version="1">MTKEEENILLAEGEMLPVMEHFYTLQGEGAHTGKAAYFIRLGGCDVGCHWCDVKESWDPTLHPLMSAVQIAETAAKHCKTIVLTGGEPLMWNLEILTSRLKELGCTIHIETSGAYPMSGHLDWITLSPKKTGLPKDQIYAKAHELKVIVFNNNDLKFAAEQAAKVSPTCRLYLQSEWSKREEIYPKITDFILANPEWQASVQTHKYLNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZS1</accession>
    <name>C6WZS1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mce4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781753.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00131"/>
    <dbReference type="EnsemblBacteria" id="ACU06606">
        <property type="protein sequence ID" value="ACU06606"/>
        <property type="gene ID" value="FIC_00131"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00131"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054524_1_0_10"/>
    <dbReference type="OMA" id="KLNPKRY"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="318" mass="35131" checksum="FC81F85B97171F07" modified="2009-09-22" version="1">MKFSKEIKAGLIALLAIIGFVILFQFMKGKSLFTTDNIFYAQFDNVEGLAASNPVSINGLKVGQVDEIIPITQNDGKIHFVVKVTIDDNFEFSKRSTLEIFEPGLMSGKEMRVNLAYGSPMAKDGDTLKGAFTLSMMNNISSQVGPVKDQLQIVLRRVDSLTNNANQILNEENKMEIRALLRNLNTTVSSFESTARQTNALVANNDPRVQRMLDNANLATISARTAIDKYGRVADEVDVQKLNNTIDKLSQTADKLNGVISGIQNGEGSLGKLTQDEELYRNLNESSANLNNLILDLKTNPKRYLNFSVFGKNSTPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZW4</accession>
    <name>C6WZW4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-haloalkanoic acid dehalogenase</fullName>
            <ecNumber evidence="1">3.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.8.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00174"/>
    <dbReference type="EnsemblBacteria" id="ACU06649">
        <property type="protein sequence ID" value="ACU06649"/>
        <property type="gene ID" value="FIC_00174"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00174"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_10"/>
    <dbReference type="OMA" id="DHTLWDF"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018784">
        <property type="term" value="F:(S)-2-haloacid dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011951">
        <property type="entry name" value="HAD-SF_hydro_IA_YjjG/PynA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02254">
        <property type="entry name" value="YjjG/YfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="234" mass="27817" checksum="72B33C22EA78EB58" modified="2009-09-22" version="1">MCSMKIKHIFFDLDNTIWDHRRNAYLTLKDIYSRENVKDRYNVGFEEFHKEYFTINERLWAQIRDGEIDKEHLRKHRFHDSFLFFGIDDYALAQLFERNFLDEILNYNDLVEGAFDLLEYLAEKNYRLHILSNGFEEVTYRKCELSGIKNYFETITSADEINIRKPHPEIYEHALKKAGATIEESVMIGDDWIADVEGGKSYGLKVIFFDVFNDNFEAEDVLVIKKLAELKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X006</accession>
    <name>C6X006_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="5">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ribA</name>
        <name evidence="7" type="ordered locus">FIC_00217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781838.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00217"/>
    <dbReference type="EnsemblBacteria" id="ACU06691">
        <property type="protein sequence ID" value="ACU06691"/>
        <property type="gene ID" value="FIC_00217"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00217"/>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_1_10"/>
    <dbReference type="OMA" id="GQGFILY"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="6">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="49"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="204" mass="22996" checksum="75A8C6E700050030" modified="2009-09-22" version="1">MLKIQAEANVPTEFGSFRIIALSETDNNWMPHLAIVAENTDFCQPVNVRFHSECITGEVFHSKKCECGQQLDAAMKYMHENGGIIIYLRQEGRNIGIINKLKAYSLQEKGFDTVEANLELGLPADDRNFAVAVEILNILEVKDVNLLTNNPEKIKVVENSNIHLNSRIPLQISSTTDSASYLKVKKDFFGHFLDDENDIKDITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X049</accession>
    <name>C6X049_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781881.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00261"/>
    <dbReference type="EnsemblBacteria" id="ACU06734">
        <property type="protein sequence ID" value="ACU06734"/>
        <property type="gene ID" value="FIC_00261"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00261"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027424_1_0_10"/>
    <dbReference type="OMA" id="LGYGDCK"/>
    <dbReference type="OrthoDB" id="956262at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973433" evidence="1">
        <location>
            <begin position="19"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3857" evidence="3">
        <location>
            <begin position="52"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="279"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="627" mass="71020" checksum="A6F7601C170B4CBE" modified="2009-09-22" version="1">MIKIYTLCFAFLSIILSAQDYGVASIPENLLENSKAIIRESSKDHILKAVNEMEIKSTRAVTVLNASGEEFGVVGIAYSPTHKVSNIKVELYDDTGKMVRTFSRKDFSDYTHNPSAGLYVDDRILVLRPVYTKYPYTVKASYEVNTSDTAFLNFTPVSSYHLAVQKSSFTMLNKSGIKIRTKISDKPLAKVNHSEDGGLWQYSYENIPAVLREDLAPSIDYLVPEVEFSPEKFSLAGRQGDMTTWDSFGKWYYHQLMSPVSELTPQIKAEVAALNLTGSTEEKVKKIYHYMQDKTRYVFIAMGIGGWQPMPASEVSAKGYGDCKALTNYMRTLLLAAGIPSYYAIIYADDSVISFDKDFPKFSGNHAILMVPTEKETIWLENTSQKVAYNHLFYSSHNRNALAVKENGIEIVNTPIYQPEQSKEKMFATIALQADGSIASEAKFEFSGGQYDSNLPLIGLKDDEVQETMKSRHYNLKIDKIGVQNLRNDRENGKIGYDLKLSANGFAKKLGDDLFFPVMPYYQSMTLSGNDERKHPFENSFPFQDDYEIEYSLPAGYRFTDIPAPSTVTTEFGTYSINFKVNENKLRVHRILTIHKGLYPKEKYKEYLAFRKKTASNDNTKILITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X053</accession>
    <name>C6X053_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsU</name>
        <name evidence="7" type="ordered locus">FIC_00265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781885.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00265"/>
    <dbReference type="EnsemblBacteria" id="ACU06738">
        <property type="protein sequence ID" value="ACU06738"/>
        <property type="gene ID" value="FIC_00265"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00265"/>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159258_2_0_10"/>
    <dbReference type="OMA" id="RQQFTKP"/>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="65" mass="7548" checksum="80E25F215E4DEF93" modified="2009-09-22" version="1">MLIIPVKDGEAIDRALKKYKRKFDKTGTIRALRSRQQFNKPSVVNRQSKLKAAYKQKNASREEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X072</accession>
    <name>C6X072_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781904.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00290"/>
    <dbReference type="EnsemblBacteria" id="ACU06757">
        <property type="protein sequence ID" value="ACU06757"/>
        <property type="gene ID" value="FIC_00290"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00290"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114536_0_0_10"/>
    <dbReference type="OMA" id="WCGDAAH"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="186" mass="21760" checksum="AA6812E4C32FF1A0" modified="2009-09-22" version="1">MKKYWQLALTFDEYMQESKRRVTDTPRTDEYFEYYELGLHRMERTLKTFKIDEQMLETLKSKDFVGRILIISEPWCGDASATVPAVATFFEAAGIDVKVFLRDSDTSLIDQYLTNGTQSIPKILILDQDLSVKNVWGPRPEFGNQLLAKFKENEASYPREEFYNDLQVYYAKNRGRDAINEIINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X086</accession>
    <name>C6X086_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ordered locus">FIC_00304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00304"/>
    <dbReference type="EnsemblBacteria" id="ACU06771">
        <property type="protein sequence ID" value="ACU06771"/>
        <property type="gene ID" value="FIC_00304"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00304"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_2_10"/>
    <dbReference type="OMA" id="YVALVPW"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="166"/>
            <end position="192"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="237"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU06771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="555" mass="62988" checksum="BE46A16B3A73CA4A" modified="2009-09-22" version="1">MIRNLYKPASMKYIILSLISAMLLSISWPTYGIPFFIFFALVPLLMMEHDISKFSNLKNKGWAVFGLSYLCFMIWNIVTTGWLYGSKNPDGTNSLAAVVLPVIFNSLFYALVFQLYHWYKNAQGTYFGLAFFVAIWMCFEKFHMSWELTWPWLNLGNVFADYPKIIQWYDTFGATGGSFWILLVNVYAFYTLRIYEAGRKRKSLILNSSIILLGILLPMLISVVKYNNFYLKPTGSVNVLMLQPELDPYTEKYSKDSLTILNDLLTLAEQNSKGQIDYFVGPETSIPGFGSISESSFEQSMLLNSVKDFLTRHPKSVFATGISSHQFYPNAELKSKTAYQTSSGIFVDSYNSAVQIIPNQKVEVYHKGKLVPGVEIFPYINFLQPVLGDAMLNLGGTVASLAIDEERKVFANPFNSGKMAPIICYESIYGEFVTDYVKKGANFFAIMTNDSWWGVTQGHKQLMSYAKLRAIENRREIARSANSGISAHIDARGEVLADTLYGDKTALFAKVNLYEHMTFYSRAGDLISRLMVYVLGFLIFYTLIKKFQNRKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X091</accession>
    <name>C6X091_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein yicC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781923.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00309"/>
    <dbReference type="EnsemblBacteria" id="ACU06776">
        <property type="protein sequence ID" value="ACU06776"/>
        <property type="gene ID" value="FIC_00309"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00309"/>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_076609_1_0_10"/>
    <dbReference type="OMA" id="EIKSVNH"/>
    <dbReference type="OrthoDB" id="1509828at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
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    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="201"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="285" mass="33061" checksum="AF3604407A19F382" modified="2009-09-22" version="1">MILSMTGFGRSEGVYEGTKITIDLKSLNSKSLDLNIKMPVRYKEKEFDLRKILNDGILRGKVDCYINVENLNDAADVNVNHDLVNAYIAELKKIAADGPEFEYLKMAVRMPDAISAKQDELEEKEWLFITGLVKEALAKFDNFRKTEGDILFEELKRNIHNIETYLSMVVPYEGVRLEAVKERYLNTLQEFGQLDETRFYQEMAYYTEKLDIAEEKVRLTQHLKYYSEVMKNEDYNGKKLGFISQEIGREINTLGSKANHAEIQKLVVMMKDDLEKIKEQTLNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B3</accession>
    <name>C6X0B3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_00331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00331"/>
    <dbReference type="EnsemblBacteria" id="ACU06798">
        <property type="protein sequence ID" value="ACU06798"/>
        <property type="gene ID" value="FIC_00331"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00331"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_2_0_10"/>
    <dbReference type="OMA" id="KYADNAF"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="307"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="249"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU06798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="395" mass="44283" checksum="56F1CC6D27D675B2" modified="2009-09-22" version="1">MTANCKLMKITVVGTGYVGLANAVLLAQQNDVVALDIIPEKVAMINERKSPLEDAEISEYLANRQLRLRATTDPADAYSDATYVIVATPTDYDPKTNYFDTRSVEAVVRQVQHYNPQAVVIIKSTVPVGFTADLSTQLNFSNIIFSPEFLREGKALYDNLYPSRIIIGEQSDRAVRFAALLQQGAIKQDIDVLYTDATEAEAIKLFSNTYLALRVAYFNELDTYAQTHELNSRQIIEGVSLDPRIGSHYNNPSFGYGGYCLPKDTKQLLANYDAVPNNIIKAIVDANRTRKDFIADSILAKNPEKVGVFRLIMKAGSDNFRASAMQGVMKRIKAKGIEVIVYEPVLQEEQFFGSRVEKDLERFKEECDIIITNRLTTELVSVKNKVYTRDLFGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F3</accession>
    <name>C6X0F3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781986.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00372"/>
    <dbReference type="EnsemblBacteria" id="ACU06839">
        <property type="protein sequence ID" value="ACU06839"/>
        <property type="gene ID" value="FIC_00372"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00372"/>
    <dbReference type="eggNOG" id="ENOG5030S7G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079297_0_0_10"/>
    <dbReference type="OMA" id="WLFTERE"/>
    <dbReference type="OrthoDB" id="1553745at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="303" mass="35979" checksum="9762476B37D046E7" modified="2009-09-22" version="1">MKKFLLKTFLFFLLTVFGLSIILVNYGGYVDYFYEKFTVSKQTSMILGDSRSLQGIQPRIVDQHLNDSGFELPMFNYSFTIAQINYGKPYTESIIKKLQPSKKGLFIVSVHPWLFTEREGDDLENHVYSETTKPPYNMAFVNVNPNFEYLIRNFQYFHFGTIIRKTVRLHKDGWLEESNLPKDTVDLNHWKNVQNKMYKDFSIRWEESPKRVEDFTEMIKFLQQNGRVVLVRMPVDSTILNIENRFWSNFDEEMNRLGDEHNITYFNFSKSDKFRTYDGNHIDKYGGIAFTKELCDSIKLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F9</accession>
    <name>C6X0F9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00378"/>
    <dbReference type="EnsemblBacteria" id="ACU06845">
        <property type="protein sequence ID" value="ACU06845"/>
        <property type="gene ID" value="FIC_00378"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00378"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1033251_0_0_10"/>
    <dbReference type="OMA" id="YNELPTI"/>
    <dbReference type="OrthoDB" id="1148617at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="311" mass="32105" checksum="DEF968CB72CB035E" modified="2009-09-22" version="1">MTSRLQLVSLWHSVCWDFTLTTKLFVMKKFFTLVGCVSALAFSNAQIVINEVYTGGGVLGAAITSDFIELKNIGAASATLSGATIQYGSAAGPFTQYNELPTITLGPGQTYLIQQASGGLGILNLLNPNLIVDVVLNFDGTGPLLGVGINLGLTSGKVALASNSAQVTGPTASNVLDFVGYGISNQFEGSGAAPSPTILNSISRTAGDTNDNDVDFTISLPTPQSGGVLATGEGSTGAKNTLIRNSRVNNGVIVFAADAEQVKIYSFTGQLLRSVTAKAGGALNVADLPNGNYIISGSVNYQPVSQKFVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0H5</accession>
    <name>C6X0H5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ordered locus">FIC_00394</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782008.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00394"/>
    <dbReference type="EnsemblBacteria" id="ACU06861">
        <property type="protein sequence ID" value="ACU06861"/>
        <property type="gene ID" value="FIC_00394"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00394"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_10"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="340"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="387"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU06861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="486" mass="52168" checksum="5905ABE91E046E5B" modified="2009-09-22" version="1">MSIHNKIVETAITFDDVLLIPSYSEVLPNQVSLKSRLSDKITLNAPIVSAAMDTVTEAEMAIAMARVGGIGFIHKNMPIEEQAAQVYRVKRSENGMISDPVTLSKDHTLMEAKEMMANFKISGLPVVDADNKLIGIITNRDVKYQENLSAKVEELMTKDKLITSDKATNLEQAKQILLKNRVEKLPIVDSEFKLVGLITIKDIDNQLEYPNANKDANGRLIVGAGVGVGEDTMDRVAALVEAGVDIIAVDSAHGHSKGVLDKIVELRKNFPELDIVGGNIVTAEAAKDLIEAGANILKVGVGPGSICTTRVVAGVGVPQLSAIYNVFEYAKSKNVAVIADGGIKLSGDIVKALASGANAVMLGSLLAGTDEAPGEEIIFQGRKFKAYQGMGSLSAMRRGGKERYFQSEAKKFVPEGIEGRVPHKGKLEEVVFQLTGGIRAGMGYCGTKDIDTLQREGKMVMITGSGLKESHPHDVIITQEAPNYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J5</accession>
    <name>C6X0J5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_00414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782028.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00414"/>
    <dbReference type="EnsemblBacteria" id="ACU06881">
        <property type="protein sequence ID" value="ACU06881"/>
        <property type="gene ID" value="FIC_00414"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00414"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_4_3_10"/>
    <dbReference type="OMA" id="TSLEMPM"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="149"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU06881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="287" mass="30918" checksum="C30C22C784691DD3" modified="2009-09-22" version="1">MEMNVSNNEEQVVAKKLGGLNPALILPILILIGYLIYYFVLGNPGNFREDARLTGASVGFSGLDTKELHPEGFMGIIYMGGPIVPILISFMIIVLVFSIERAMVLRKASGAGNVDNFVLSIRRLLNQNKVDEAIEECDRQQGSVGNVVREGLTTYKALAHDTTMNKEQKMVALNKSIEEATTLEMPMLEKNMMILSTLGTVATLVALLGTVIGMIKAFNALGSGGGTPDSAALSIGISEALINTALGIGTSAVAIIFYNYFTSKIDGLTFKIDEIAMSIQQSFAEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0L1</accession>
    <name>C6X0L1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782044.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00435"/>
    <dbReference type="EnsemblBacteria" id="ACU06897">
        <property type="protein sequence ID" value="ACU06897"/>
        <property type="gene ID" value="FIC_00435"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00435"/>
    <dbReference type="eggNOG" id="ENOG5032V4W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1388425_0_0_10"/>
    <dbReference type="OrthoDB" id="1914696at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970514" evidence="1">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="196" mass="22122" checksum="5D36CBABE189D795" modified="2009-09-22" version="1">MKKNLVFFALIVFTFGFSQCYVDGSPTIYVGETQTYTVKNNVAKCATCYSWSATEGNINIKTSKTENLEITGLAEGTSMIFLTMQTAKGEARCNKNISILPAVIRENPDCDVYYSGFSEKKSGDGQVTFVHKKSDAYSYRWTALFDDGTSETSTDAFPTFKFTKNNQIGKISVQILAEQCMRTYSKTYEKNFWTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0N2</accession>
    <name>C6X0N2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase, NPD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00456"/>
    <dbReference type="EnsemblBacteria" id="ACU06918">
        <property type="protein sequence ID" value="ACU06918"/>
        <property type="gene ID" value="FIC_00456"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00456"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_1_1_10"/>
    <dbReference type="OMA" id="IDDLPSC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="61"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="292" mass="31826" checksum="C173C513445D37C6" modified="2009-09-22" version="1">MIWHSGWRLASAVSNSGGLGLIGAGSMYPDILRENIRKCKSATDKPFGVNVPMLYPNLDEVIKIILEEGVKIVFTSAGNPKTYTQMLQKEGLKVAHVVSSTKFAMKCEDAGVDAIVAEGFEAGGHNGRDETTTFCLIPNVKKHITKPLIAAGGIALGSQMKAAMILGADGVQIGSRFAATEEASSHTDWKNKVISLDEGDTQLTLKELAPVRLVKNKFFHDLEKLYETGRDAEALKQTLGRARAKRGMFEGDLEEGELEIGQVSALIDEILPVEKVFENLLKEYREATSFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P8</accession>
    <name>C6X0P8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Fe3+-siderophores transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782081.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00472"/>
    <dbReference type="EnsemblBacteria" id="ACU06934">
        <property type="protein sequence ID" value="ACU06934"/>
        <property type="gene ID" value="FIC_00472"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00472"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_7_10"/>
    <dbReference type="OMA" id="FSWYGSR"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="239" mass="27281" checksum="B766B3E918F003B1" modified="2009-09-22" version="1">MRIISLVPSITETLFDLGADEIVGRTKFCIHPKDKVSDVEIIGGTKNVNIQKIINLEPDLIIANKEENVKEQIVELQQSFKVLLTDISTLEDNYYLLKTLGNLLGKQEIAQKYNSKINEIFNGLQISEKKSCVYLIWKNPYMTVGGDTFIHAVLQQAGFENIFKDQRRYPEISVEQMKGAEYIFLSSEPFPFKEKHVDELQKLLPGSRIILVDGEAFSWYGTHLAKCEDYFKKLAGNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0S1</accession>
    <name>C6X0S1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01587"/>
    <dbReference type="EnsemblBacteria" id="ACU08034">
        <property type="protein sequence ID" value="ACU08034"/>
        <property type="gene ID" value="FIC_01587"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01587"/>
    <dbReference type="eggNOG" id="COG4068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148614_0_0_10"/>
    <dbReference type="OMA" id="CRNAYNN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="118" mass="13916" checksum="C368EF2DFBC21E1D" modified="2009-09-22" version="1">MIAMQDCLECGEKIIGRSDKKFCNDGCRNAYNNKHNKDSSNLMRNINNKLRKNHRILSEQKFTEGKAKTTRNKLTSEGFDFGYFTSLKIYKNGAEYRFVYDIGYKLLEEDWILLVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0U1</accession>
    <name>C6X0U1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806339.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01608"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08054">
        <property type="protein sequence ID" value="ACU08054"/>
        <property type="gene ID" value="FIC_01608"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01608"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_10"/>
    <dbReference type="OMA" id="PLYVIVH"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="360" mass="41457" checksum="2583912E11342F8B" modified="2009-09-22" version="1">MKKTSIIFILPDLETGGAERIITTIANELPRGIFEPKILLLRKTGAFLGNVKDDVEIIDIKTQKIRFALKPILLEIKHRKPDIVFCGFGEINAYLSLFIPLFPKTKFIARETNVVSQHVKRPEIRFFYKFYNNFHRIVAQSDDMKNDLIANFSVRPEKIIKINNPVDLDYIGRQTENATLPESFKQDFKNVVAIGNLSARKGFDHLLKVFSQLRNEKFLLHIIGSGRDYGMLEQLRTDLNLENVIFHGQQDNPYRFLKFADLFILSSRYEGFPNVLLEAGACGIYSLANNCPGGILEIIQPKINGETDNITNHEAFAEKIKLILREDHNEDNIRFSIKSRFEKNLIMKQYENILINIALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0X9</accession>
    <name>C6X0X9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="2" type="ordered locus">FIC_01648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806377.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01648"/>
    <dbReference type="EnsemblBacteria" id="ACU08092">
        <property type="protein sequence ID" value="ACU08092"/>
        <property type="gene ID" value="FIC_01648"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01648"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_4_1_10"/>
    <dbReference type="OMA" id="NPIENRD"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="120" mass="13631" checksum="5FF406871A454A54" modified="2009-09-22" version="1">MNESNRQRKVAQIIQQDLAELFRKQASDSKQNFLVTVSDVKITADLSIAKVYLSIFPPAVRAAVMKEIEQNTSAYRNFIGQKMGKQVRIIPDVKFYLDTTLDDVEKIEKELKGEGDNPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X113</accession>
    <name>C6X113_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkylphosphonate utilization operon protein PhnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806411.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08126">
        <property type="protein sequence ID" value="ACU08126"/>
        <property type="gene ID" value="FIC_01683"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01683"/>
    <dbReference type="eggNOG" id="COG2824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134486_0_0_10"/>
    <dbReference type="OMA" id="SCLYEWN"/>
    <dbReference type="OrthoDB" id="1507972at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="110" mass="12061" checksum="BA2BF931E898B2C0" modified="2009-09-22" version="1">MSDTLTCPKCNSEFTYAQDELMVCSQCFHEWNPADEENGDAILDMNGNVLVDGDSVIVMKDLPVKGAPKPVKAGTKVKNIRLRPLSDHNIDCKIDGFGAMALKSEFVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X153</accession>
    <name>C6X153_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806451.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01723"/>
    <dbReference type="EnsemblBacteria" id="ACU08166">
        <property type="protein sequence ID" value="ACU08166"/>
        <property type="gene ID" value="FIC_01723"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01723"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_31_8_10"/>
    <dbReference type="OMA" id="CRYLDCQ"/>
    <dbReference type="OrthoDB" id="2040098at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="71" mass="7967" checksum="6535E94184BB4335" modified="2009-09-22" version="1">MPIIVNLDVMMAKRKMSLNELSEKVDLTLSNLSILKTGKAKAVRFSTLEAICKALDCQPGDLLEFVREEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X155</accession>
    <name>C6X155_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01725"/>
    <dbReference type="EnsemblBacteria" id="ACU08168">
        <property type="protein sequence ID" value="ACU08168"/>
        <property type="gene ID" value="FIC_01725"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01725"/>
    <dbReference type="eggNOG" id="ENOG5033FCV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2584593_0_0_10"/>
    <dbReference type="OrthoDB" id="2079169at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="80" mass="9255" checksum="C2F4034A19181161" modified="2009-09-22" version="1">METKVKIKSKGKIFIIHKNDADPFPSNPHAHWIDTNLKIDLSNGKCYHIRKHISTLSKKEFNELRTKAVEIGIKLPEPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>C6X173</accession>
    <name>C6X173_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Xylose isomerase</fullName>
            <ecNumber evidence="2 8 9">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylA</name>
        <name evidence="11" type="ordered locus">FIC_01743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8 9">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the xylose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2 8 9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01743"/>
    <dbReference type="EnsemblBacteria" id="ACU08186">
        <property type="protein sequence ID" value="ACU08186"/>
        <property type="gene ID" value="FIC_01743"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01743"/>
    <dbReference type="eggNOG" id="COG2115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037261_1_0_10"/>
    <dbReference type="OMA" id="TLAMYEI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013452">
        <property type="entry name" value="Xylose_isom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02630">
        <property type="entry name" value="xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0859">Xylose metabolism</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="461" mass="51746" checksum="5F8166E524C7F1C4" modified="2009-09-22" version="1">MTGKSYANIKENLLNKNYNMNILKGTKEFFPGVEQIKFEGVESRNPLAFRYYDADRVVMGKPMKEWMRFATAWWHTLCADGSDPFGGPTIHHPWGTASDVIDRAKYKMDAGFEFMTKMGFGYYCFHDVDLVDPSDNWKEYEANLQTIVEYAKEKQAASGIKLLWGTANVFSHERYMNGASTNPNFDVVACAATQVKNSIDATIALGGENYVFWGGREGYMSLLNTDMKREKDHLARFLTMSRDYARSQGFKGTFLIEPKPMEPTKHQYDYDAETVIGFLRYYGLDKDFKLNLEVNHATLAGHTFEHELQAAVDAGMLGSIDANRGDAQNGWDTDQFPIDTFDLTQAWLAILPNGGLGSGGINFDAKIRRNSTDAEDLFIAHVAGMDAFARGLIAAAGILENSDYNKLRTERYASFDSGNGKAFEQGTLTLEDLRKIAHESGEPQPKSGKQELFEAIVNMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X186</accession>
    <name>C6X186_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01756"/>
    <dbReference type="EnsemblBacteria" id="ACU08199">
        <property type="protein sequence ID" value="ACU08199"/>
        <property type="gene ID" value="FIC_01756"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01756"/>
    <dbReference type="HOGENOM" id="CLU_3365106_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="35" mass="4146" checksum="910A0CD375E02292" modified="2009-09-22" version="1">MNFFCSKIAFVFLLKSLRKQIFSGDRPQDLLKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E4</accession>
    <name>C6X1E4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensory transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806542.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01814"/>
    <dbReference type="EnsemblBacteria" id="ACU08257">
        <property type="protein sequence ID" value="ACU08257"/>
        <property type="gene ID" value="FIC_01814"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01814"/>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470713_0_0_10"/>
    <dbReference type="OMA" id="MAREDST"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_2" evidence="2">
        <location>
            <begin position="387"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="579" mass="67204" checksum="E6E204DC13B93099" modified="2009-09-22" version="1">MVKIYACFFFLLLMIVVRAHDNFSALRSEVEQKILYSQYREALELANHERRSYPKHQQSELDVLKLECLNKLNLVDEAFALSQNILSQTHLSPKLKLRTHLQRALIYELGRNLSSCKKEVDIAEQILNRNPALKPANFTYFLIRKASYYNQAGDKQKAMQTAMDADKFAAKNKDQKNGAMLNVLLGHAWSAEPEKALRYFEKAVRLFKNHNNQGGTAGMYNIISRFYFDRSETALARKYVDSAVAKHSNIEVFHIMAESYRIRSLINERQNNYPQALKDFKTAAEFTKKDNEEQRETKVRELDLMYDFETNKLREKEMFNSMKSTRKWNSMLAICTLVLVFFTAVLLYVVRLFSRSRARIKVQNQSISEKNAALKKNVDEKEFLVRELNHRVKNNLAVILSLVGFQRDETRDVLYKNKFEQLYARINTIALAHQLFTYNVDNFDHTSVELMQYSEKIIDLHKAGSTQPLKVETEFDEVQMPVDQGLSYGLLLNELLTNSMKHAVPSDGETLKIFLKVRQNNGQAEVEYSDNGRLFTKKERKSSLGRFIIDAMIEQLRGTCSREGSYYSITFPLDGRIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E5</accession>
    <name>C6X1E5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase of class Ia (Aerobic), alpha subunit</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806543.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01815"/>
    <dbReference type="EnsemblBacteria" id="ACU08258">
        <property type="protein sequence ID" value="ACU08258"/>
        <property type="gene ID" value="FIC_01815"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01815"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_7_0_10"/>
    <dbReference type="OMA" id="LEIWHID"/>
    <dbReference type="OrthoDB" id="357568at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013350">
        <property type="entry name" value="RNR_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02510">
        <property type="entry name" value="NrdE-prime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="2">
        <location>
            <begin position="81"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="2">
        <location>
            <begin position="204"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="2">
        <location>
            <begin position="378"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="551" mass="62130" checksum="000D71A3D39E60FF" modified="2009-09-22" version="1">MEENTNIWWLNEESEQMLNRGYLLKGETVKGAIERITTAAAKRLYKPELQPAFEEMITKGWISFSSPVWANMGTQRGLPISCFNVHVPDHIEGITHKLGEVIMQTKIGGGTSGYFGELRNRGTAVTDNGKSSGAVSFMKLYDTAMDVVSQGGVRRGAFAAYLDIDHGDIEEFLSIKDIGSPIQNLFTGICVPDYWMQDMIDGDMDKRKIWARVLESRQQKGLPYILFSDNVNRNKPQVYKDLGMTINASNLCSEIMLPSNAEESFICCLSSMNLELYDEWKDTNAVKLAIYFLDAVLSEFIEKTEGNYYLTGARNFALRHRALGLGVLGYHSYLQKNMIPFESFEATQFNARAFRQIKEQSLAASQELANIYGEPELLKGYGMRNTTTMAIAPTTSSSAILGQTSPGIEPFASNYYKAGLAKGNFMRKNKYLAKLLQEKGLDNEETWRTIMLNHGSVQHLNELTEEEKAVFKTFREISPMEIISQAAQRQQYIDQAQSLNLQIPSTMPVKDVNYLYIEAWKKGVKTLYYQRSSSVSKEMMVNFVTCSSCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1I0</accession>
    <name>C6X1I0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase in aerotolerance operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806578.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01850"/>
    <dbReference type="EnsemblBacteria" id="ACU08293">
        <property type="protein sequence ID" value="ACU08293"/>
        <property type="gene ID" value="FIC_01850"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01850"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_10"/>
    <dbReference type="OMA" id="SRAWAWL"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="54"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="260"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="334" mass="37760" checksum="86FAA23C718F6971" modified="2009-09-22" version="1">MSEQYQAEDIRILTEKVREQNYFFTLLKQEINKAIIGQEYMVDRLLIGLLGNGHVLLEGVPGLAKTLAIKTLADAVQGDFSRIQFTPDLLPADVVGTMMYNIKDNDFTIKRGPVFANFVLADEINRAPSKVQSALLEAMQEKQVTIGDETMNLPKPFLVLATQNPIDQEGTYLLPEAQTDRFMLKCTITYPDFEDERKIMKMVATSHQLEIRPVISLQNIVEAKNLINQIYLDEKIEKYILDMVFATRFPEKYGLAELKNYISFGASPRASINLAIASRAMAFLKNRAFVLPEDVKEIAKDVLRHRIGLSFEAEAEEITADEIVDRILGKVQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1L4</accession>
    <name>C6X1L4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Altronate oxidoreductase</fullName>
            <ecNumber evidence="3">1.1.1.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.58" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806612.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01884"/>
    <dbReference type="EnsemblBacteria" id="ACU08327">
        <property type="protein sequence ID" value="ACU08327"/>
        <property type="gene ID" value="FIC_01884"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01884"/>
    <dbReference type="eggNOG" id="COG0246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027324_1_0_10"/>
    <dbReference type="OMA" id="VVIVRPI"/>
    <dbReference type="OrthoDB" id="1442117at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009026">
        <property type="term" value="F:tagaturonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="1">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="2">
        <location>
            <begin position="211"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="489" mass="55665" checksum="AE23B5250FF41B5F" modified="2009-09-22" version="1">MTTDINTKPRLNREAYSAGNKLPVKILQFGEGNFLRAFVDYAFQALNNELGFNAGVAVVQPLPGGMVGMLEEQDGIYTVFLNGIKNGKKIQEVHLIDNIVQCINPYTDFQALLDVAREESLEFIISNTTEAGIEFVDTDVLSDESPKSFPAKVAAVLYERYTHFKGDRSKGLTIIPCELINYNADTLKTVLLQYHELWKLEDDFAAWINEACTFHNTLVDRIVPGYPKDEEAEFQNKLEYHDKFMVTAEPFFLWVIEGDEKLKEKLPFDKTNLDVKIVADMQPYRDRKVRILNGIHTAMVPFSVMYGNETVQETVGDPFTMKYVSEIAFNEILPTLNMDKDELNKFTEEVLDRFRNPFIRHQLSDIALNSISKFKVRVLPTIVEYFGKYQKLPVNLVFGFACLIRFYKGSWNGKILPVKDSPEIIAAFDAAWINTSLEGTVSEILENTEFWGEDLNQISGLSAAIVYAIENAEEHGIEIGYQNFISHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1P8</accession>
    <name>C6X1P8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806646.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01919"/>
    <dbReference type="EnsemblBacteria" id="ACU08361">
        <property type="protein sequence ID" value="ACU08361"/>
        <property type="gene ID" value="FIC_01919"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01919"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_3_1_10"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="254" mass="29643" checksum="0AF0C574E5E6D684" modified="2009-09-22" version="1">MKIISYNVNGIRAAFTKNFVGWLEVADPDIICIQESKAGNDQIDIESFEKIGYHSYWHSAQKKGYSGVGIASKIKPNYVEYGCGIEHYDSEGRIIRADFDDFSVISVYVPSASNIERLGYKMEFCYDFLQYIKNLKKTIPNLIISGDFNICHKPIDIHNPEGLKNASGFLPIEREWLSKFIDECELIDSFRYFNDQPDYYTWWSYRQNSRERNKGWRLDYNFVSNSLKEKLSRAVILKEVFHSDHCPVLVEIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Q2</accession>
    <name>C6X1Q2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806650.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01923"/>
    <dbReference type="EnsemblBacteria" id="ACU08365">
        <property type="protein sequence ID" value="ACU08365"/>
        <property type="gene ID" value="FIC_01923"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01923"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_3_10"/>
    <dbReference type="OMA" id="SFKIDVR"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="156" mass="18267" checksum="EC26AA43EEA4A12D" modified="2009-09-22" version="1">METSKKIIGITFSCFDLLHAGHVRMLAEAKQQCDYLIVGLQTDPTIDRPEKNKPTQTVVERYIQLKGCKYVDEIVPYTTEKDLEDILKLYPIDVRIIGVEYKDKEFTGRDFCERKNIKLFYNERNHRFSSTNLRKEVYKRESLKLNGASHGMEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y1</accession>
    <name>C6X1Y1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ordered locus">FIC_02002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806728.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02002"/>
    <dbReference type="EnsemblBacteria" id="ACU08444">
        <property type="protein sequence ID" value="ACU08444"/>
        <property type="gene ID" value="FIC_02002"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02002"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_10"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="148" mass="15734" checksum="6B08FF4D1C1B87D1" modified="2009-09-22" version="1">MNLNNIRPASGSTHNSKRLGRGQGSGKGGTSAKGHKGQKARAGYSQKIGFEGGQMPLQRRLPKFGFTNVNRKEYRAINIDTIQLLADAKGITEITKDILVENGLAKKSEIVKIMGRGELTTGVSVSAHKFTKSAEEAIAKAGGKAITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X279</accession>
    <name>C6X279_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c551/c552</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806826.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02105"/>
    <dbReference type="EnsemblBacteria" id="ACU08542">
        <property type="protein sequence ID" value="ACU08542"/>
        <property type="gene ID" value="FIC_02105"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02105"/>
    <dbReference type="eggNOG" id="COG4654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141558_0_0_10"/>
    <dbReference type="OMA" id="MGPALHD"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002324">
        <property type="entry name" value="Cyt_c_ID"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00606">
        <property type="entry name" value="CYTCHROMECID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="128" mass="13687" checksum="B6AC85E7F74636F9" modified="2009-09-22" version="1">MNKYCAVAILMIAVSCGKNEVDSGKESNVMLEEPTIQVVDSAAAGKHEGLALIEGADCLTCHKVDARVVGPSYQEVADKYTEADIEMLAGKIIDGGKGNWGEIPMTPHTGMSEANAKKMVEYILTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B1</accession>
    <name>C6X2B1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02138"/>
    <dbReference type="EnsemblBacteria" id="ACU08574">
        <property type="protein sequence ID" value="ACU08574"/>
        <property type="gene ID" value="FIC_02138"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02138"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_10"/>
    <dbReference type="OMA" id="PKVKYCI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="12861" checksum="9E179A6550E0F83B" modified="2009-09-22" version="1">MQYKNKGMGITKSELFTNKQNQIADLAKALAHPARIAILEYLLTVETCICGDIVNELPLAQPTISQHLKELKNAGIIKGSVEGTAICYCIDEKNLEVMQAFFSNIITQTKNKISGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E6</accession>
    <name>C6X2E6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">murB</name>
        <name evidence="18" type="ordered locus">FIC_02173</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806893.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02173"/>
    <dbReference type="EnsemblBacteria" id="ACU08609">
        <property type="protein sequence ID" value="ACU08609"/>
        <property type="gene ID" value="FIC_02173"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02173"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_0_0_10"/>
    <dbReference type="OMA" id="MQNIGAY"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ACU08609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="339" mass="37472" checksum="A7ACC75EB97BC362" modified="2009-09-22" version="1">MKIHQNFSLKNHNTFGVDVTARCFVEVSSVGDLTEALNYAKNHSLTTLFLGGGSNILFTQDFDGMVIQLNLKGISEESTSENEVFVTAKAGENWHEFVQFCLSKNYGGLENLSLIPGNVGTSPMQNIGAYGTEIKDVFGNCKVLNLDTLEVEIFNAQQCRFGYRESFFKKEGKGKYVILEVAFKLTRKNHQIRTEYGAIQAELEKLNLTNPTVQDVSMAVINIRQSKLPDPKVVGNAGSFFKNPTIPLAQFEELHVKFPLAPGYPNGDVVKVPAGWLIEQCGWKGRQIGNVASHPLQALVIVNATGKATGKEIFGFSSMIIDSVEERFGIELEREVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E7</accession>
    <name>C6X2E7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02174"/>
    <dbReference type="EnsemblBacteria" id="ACU08610">
        <property type="protein sequence ID" value="ACU08610"/>
        <property type="gene ID" value="FIC_02174"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02174"/>
    <dbReference type="HOGENOM" id="CLU_3310139_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="39" mass="4662" checksum="E8D6CB279858AB20" modified="2009-09-22" version="1">MEILSARRNDAQKDWERKTEKGAKKIITFYNITAPDLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2F8</accession>
    <name>C6X2F8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ordered locus">FIC_02185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02185"/>
    <dbReference type="EnsemblBacteria" id="ACU08621">
        <property type="protein sequence ID" value="ACU08621"/>
        <property type="gene ID" value="FIC_02185"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02185"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_1_1_10"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="134"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="339" mass="37817" checksum="E5E2F0388013BF41" modified="2009-09-22" version="1">MFKFALITLKIMNKKNVAVVMGGYSDEYVVSLKSGQLIYDSLDRDSYNVYKVIVLKDEWYFLDDREQKVPVNKADFSVNLDSGFDVKFDVCFNIIHGKPGENGELQAYWDTIGQKYTGCGFYQSALTFNKKDTLAVLSKYGIPAAKSVYIRKGEAIDEDGIIEDLKLPLFVKPNQSGSSLGISKVKDKSEFQKAIDFAFEQDDEVLIESFLDGMEVSVGVVDFNGESIVLGITEIVSHKEFFDYEAKYEGASEEITPARIDDETRQKVEEIAKKAYNSLGMSGFSRSEFIIMGGTPYMLEMNTNPGFSPASILPQQAKIYGISIKDLCGNEVEKALAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2N0</accession>
    <name>C6X2N0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02260"/>
    <dbReference type="EnsemblBacteria" id="ACU08693">
        <property type="protein sequence ID" value="ACU08693"/>
        <property type="gene ID" value="FIC_02260"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02260"/>
    <dbReference type="eggNOG" id="COG3145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048788_5_2_10"/>
    <dbReference type="OMA" id="TQHHWQH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="204" mass="23338" checksum="222B9BC1C554B13F" modified="2009-09-22" version="1">MMSLFDNISDPNLNLLPKDGTVNYYGKILSEDESSSIYQDLLDNIEWKNDEAVIFGKTMITKRKVAWYGDREFSYTYSKSTKTAIPWTATLLKLKKMVENATGEAFNSCLLNLYHSGEEGMGWHSDAEKDLKKNGAIASLSLGAERRFLFKHKHTADKVETVLEHGSLLVMKNETQSFWQHRLPPARKILTPRINLTFRSIDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Q5</accession>
    <name>C6X2Q5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807002.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02285"/>
    <dbReference type="EnsemblBacteria" id="ACU08718">
        <property type="protein sequence ID" value="ACU08718"/>
        <property type="gene ID" value="FIC_02285"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02285"/>
    <dbReference type="eggNOG" id="ENOG5033G3J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2507822_0_0_10"/>
    <dbReference type="OMA" id="TWPHIRT"/>
    <dbReference type="OrthoDB" id="1949296at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="85" mass="10178" checksum="AC8EBA07A8A7F1A2" modified="2009-09-22" version="1">MSHWKFAKAIRENEEFRIEGLNIWNHYWHCVNKKVEVIGPERGNMYHFKEYEIEHEGKTVHFVAGELMDSTVGIYLKDKLRDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2R8</accession>
    <name>C6X2R8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_34 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807015.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02298"/>
    <dbReference type="EnsemblBacteria" id="ACU08731">
        <property type="protein sequence ID" value="ACU08731"/>
        <property type="gene ID" value="FIC_02298"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02298"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142189_1_1_10"/>
    <dbReference type="OMA" id="KARLGIM"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="10935" checksum="B5EC1B1525EE6220" modified="2009-09-22" version="1">MINISNLNKEFESRVRLGIMSVLMVNEWVDFTEMKNLLEITDGNLASHSTALEKSDYIEVKKEFVGKKPRTSYRATASGKKAFDEHLTALEKLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V4</accession>
    <name>C6X2V4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolysaccharide biosynthesis protein, acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807051.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02334"/>
    <dbReference type="EnsemblBacteria" id="ACU08767">
        <property type="protein sequence ID" value="ACU08767"/>
        <property type="gene ID" value="FIC_02334"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02334"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_7_1_10"/>
    <dbReference type="OMA" id="PARIKRY"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="180" mass="20071" checksum="26B4BFFF6DF7A3EA" modified="2009-09-22" version="1">MVSLSKVFLRILKNKNLGALRNNPNIQTGRNMKLGDFCNFQMNPELQSVQIKSNVSLRNYISLLVGKNAELIIGENLFFNNYCSVNALHRIEIGDNTLFGEGVKIYDHNHQYTAEKIQHQQFNTAPVKIGKNCWLGSNVTVLKGVTIGDNVIIGAGVLVYKDIPANSIVKLKQELVTQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y0</accession>
    <name>C6X2Y0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_02360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807077.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02360"/>
    <dbReference type="EnsemblBacteria" id="ACU08793">
        <property type="protein sequence ID" value="ACU08793"/>
        <property type="gene ID" value="FIC_02360"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02360"/>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_10"/>
    <dbReference type="OMA" id="HCVQWLI"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="5"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="524" mass="58924" checksum="BD1C21B2AE481F30" modified="2009-09-22" version="1">MIKADVLVIGSGISGLSYAIKIAEKMPDAQIVIVTKADEDESNTKYAQGGLAVVTDFSNDGFHKHIDDTMRAGDGENKRDVVEMVIKEGPARFKELVDWGTNFDMEKDGDFKLGREGGHTENRIVHHKDITGSEIERALLETVNKSSKIEMLSHHYVIDLITQHHVPGKELNTGDISCYGAYVLDEKNKKIKKITAKITMVATGGAGHVYKNTTNPVIATGDGIAFVHRARGKVSNMQYYQFHPTALYSKRDGMLFLISEALRGDGAKLRTKNGEKFMHKYDEREELASRDIVARAIDNELKISGDDYVGLDCRDMDHEKFKEHFPNIYQKCLSEGIDPFQQLIPVVPACHYLMGGIETDMNGQSSIKNLFAVGECTNSGLHGANRLASNSLLEGLVFGHNAALRTVELLQANDFNFTDLKAVPEWNEEGMKMMDEMVMISYFRRHLQEMMSDLVSIVRSNERLELARKKQREIFEAVNELYSYSIMSPQLSELRNLVNVSYLIIKHSLAMKQNKGAFFNKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Z1</accession>
    <name>C6X2Z1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807088.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02371"/>
    <dbReference type="EnsemblBacteria" id="ACU08804">
        <property type="protein sequence ID" value="ACU08804"/>
        <property type="gene ID" value="FIC_02371"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02371"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134960_1_0_10"/>
    <dbReference type="OMA" id="KIAPVHK"/>
    <dbReference type="OrthoDB" id="1879806at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="136" mass="15478" checksum="65284F0B11A8C207" modified="2009-09-22" version="1">MLVTKKYATQLSYDITGLAIKVHKNLGPGLLESIYETCLKYELERNGYSVAQQVVANIVYDGLLIENNLRLDLLVNDLVIVELKTVDELKPVHQAQLLTYMKLLEKPQGLLINFNTDNIIKSMKPLVNEYFTLLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X312</accession>
    <name>C6X312_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807109.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02392"/>
    <dbReference type="EnsemblBacteria" id="ACU08825">
        <property type="protein sequence ID" value="ACU08825"/>
        <property type="gene ID" value="FIC_02392"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02392"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_10"/>
    <dbReference type="OMA" id="FAGIHFT"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="57"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="541" mass="59900" checksum="9B11ABB039ADDA5E" modified="2009-09-22" version="1">MTKAISQVPFAANEPVRTYEPGSAEVKSLISMYKKMWNEKAEIPMIINGKEVITEDKVAINSPQDHEHDLGFYYKGNMQHVDDAINTALAAKEKWNKLGWEHRAAIFLKAAELIAGPYRDRLNAATMIGQSKNVHQAEIDAACEFIDFLRYNVEFMTEIYSEQPVSDTGIWNRSEYRPLEGFCFAVTPFNFTAIAGNLPTCMAMMGNVVVWKPSNNQVLSAQVIMDVLIEAGLPAGVINLIFTDGKETAEKVLAHPEFAGLHFTGSTSVFQGMWKMIGNNIHQYKTYPRIVGETGGKDFVMVHPSANAAAVATALVRGAFEYQGQKCSAASRAYIPKSLWNEVKEIMGAQLKTVKMGSPEDPSNFVNAVISQGSFDKCKGYIERAQNSADAEVIFGGKCDDSKGWFVEPTVIETTNPNYESVCEEIFGPILSVYVYEDLKWNETLKLVDQTSIYSLTGSIFAQDRYAIEEAYNALENAAGNFYINDKPTGAVVGQQPFGGARASGTNDKAGSKMNLLRWTSVRSIKETFVSPKDYKYPYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X322</accession>
    <name>C6X322_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807119.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02402"/>
    <dbReference type="EnsemblBacteria" id="ACU08835">
        <property type="protein sequence ID" value="ACU08835"/>
        <property type="gene ID" value="FIC_02402"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02402"/>
    <dbReference type="eggNOG" id="COG1510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120349_3_1_10"/>
    <dbReference type="OMA" id="TGDRKKY"/>
    <dbReference type="OrthoDB" id="1646730at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="151" mass="17714" checksum="BB3A89289D79C33A" modified="2009-09-22" version="1">MAAALQFDEKLFGELVKFYGETFHLPPLSAKIYAYLIFDFERTGICFDEFVQVFAASKSSVSSNLNLLINARLIKDFNTINERKRFFTVNDDFISIRFTEIVNKMKQELVILDKLHEFRSQTDDSAAQRFEIYKELLNKNIKNIEETLHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C5</accession>
    <name>C6X3C5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02508"/>
    <dbReference type="EnsemblBacteria" id="ACU08938">
        <property type="protein sequence ID" value="ACU08938"/>
        <property type="gene ID" value="FIC_02508"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02508"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030408_3_0_10"/>
    <dbReference type="OMA" id="ERWALAN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="601" mass="68967" checksum="979CEBD5B4BE323E" modified="2009-09-22" version="1">MRCFFVCLIFILLSCANEGQSIDLSKSNISYQEHDHETGWKRIRLLKPNKWGFVNDRNKIMIPFDYDFLNPFEKGLSYAKRDGKDFFITRKNLKLSGDYDEAGIFTFGLAPVSKNNKWGFIDENGVVVIPMLYDEVQYFTQNNLSAVTKNGKSGFIDKHGREIIPIAYDQVISEQLDNMVITRKDDKWAFFDNTGKQLSGFIYDKVQRAWKGDDTTFFENGPASVKLNGKYLFLDKNLQPVFSKVRFDSATSFDSNGNAIVMKKARFGILKNDGRLVIPIEYSAIENYNSNGDPNPKFYSLKKDGRYALLNLDLLKIAESDENYFNLTVVNGTEYISFKNGKNRYGLVDQKGNIKVPFIYNETLYFDRNPFSIAKKDNRQGIIGINNRVIIPFDYGEIVQIDDEETDLFIASNKGGDAVMNLDHKTILTGEKIHSIYNHPLKFIVKRKGKYGIVDLQNKIILPFEYDEISNWTEYGPRVSKFIIKDGKTGLIDENTFKITIPPVYDEFKYVNGLIFAKRNKKAGIIDESGKVLCPFVFDQIYPSLLDVYDPRSNELRIFARKGRDYYQVDHSGKILKSNITLPEVLKQTVLPELPPPPKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3E2</accession>
    <name>C6X3E2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02525"/>
    <dbReference type="EnsemblBacteria" id="ACU08955">
        <property type="protein sequence ID" value="ACU08955"/>
        <property type="gene ID" value="FIC_02525"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02525"/>
    <dbReference type="HOGENOM" id="CLU_3389562_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="32" mass="3540" checksum="36C2FC9D08A0A096" modified="2009-09-22" version="1">MLRSSVFTEGTNTLPKANNDVMAGKTFASHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3F0</accession>
    <name>C6X3F0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DinB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807247.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02533"/>
    <dbReference type="EnsemblBacteria" id="ACU08963">
        <property type="protein sequence ID" value="ACU08963"/>
        <property type="gene ID" value="FIC_02533"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02533"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1633040_0_0_10"/>
    <dbReference type="OMA" id="AQLGVYY"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="19133" checksum="32C33F0FBF995051" modified="2009-09-22" version="1">METLNNLRTEFAEEFKITKKFLERYPEELNTYAPHEKSMKMLPLATHIAEIFGWPAFIMNSEKLDFAAGDYQPPMLSTKAELLNTLEDGYSKSEATLNNMSEQDLDGRWTINMGDQIISDFSKYGAIRHALNQITHHRAQLGVYYRLNNIALPDSYGPSADTENNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H0</accession>
    <name>C6X3H0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FIC_02553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807267.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02553"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08983">
        <property type="protein sequence ID" value="ACU08983"/>
        <property type="gene ID" value="FIC_02553"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02553"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_10"/>
    <dbReference type="OMA" id="ADWAGKT"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="82"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="445"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="747"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="792" mass="89350" checksum="8534539CA19450E9" modified="2009-09-22" version="1">MEKKKTSGSKPQQKFPLPPTKVKSRGWRRWVKFVWMALIAAVLGIAALFFAVSQGFLGSMPDVKELENPDIYVASEIYASDGRLLGKFEKEKTQPVTYKELPPYLIYALQAKEDERFKEHSGIDLQSVARAVVYGGQRGGGSTITQQLAKLLFTDRVSRNKVERAFQKLKEWVVAVSLEKRYTKEEIITLYFNKFDFLYNANGIEMASKIYFNKPTSQLTLPEAAMFVAMLENPVKNNPMRNMDRAKNRRDVVLDQMLKTGYIDQQTFTKAIGTPITLDYHPVKSIDEGYSAYYKFYLRKEIDGYLKDYEKKTGKTLNLFKDGLKIYVTLDSKMQVYAEEAIKEHLTDLQKRFDAEQRGRKQRPFYFLDDKQIQGVMMQAVKRTGRYKQLKNAGVSDDSIMIEFKKPIPTSRFTWNGEEEVEMSPWDSIRYHKQIAQAGLMSMVPGTGEIRAWVGGINWQHFQYDHIKQGKRQVGSTFKPFVYATAIMKLGMTPCSTVSNATYTKGTWKVEGSGGSLTLRDALAHSKNPVAVRLIEMTTPRSVIQTARDLGVTEEIPNEYAVALGSSDITIFEMLGAYSTFANYGNYIKPEMIWRIEDANGRVIKEVKPVTKEVMNELYAYTMIDLMKGVAEFGTASGELGRRGVEKGIEIAAKTGTTQNNSDGWFIGITPNLATGVWVGWEDRATHFRGTGEGQGAKMALPIWAIFMKKVWADAQSGVTKEDKFIKPSNWTGSCADLQGLGGYGDDGGLQTMDELKNPTVETPQRAPTRAAPKDENLNENLNSGDEIDFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3H3</accession>
    <name>C6X3H3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Superoxide dismutase, copper/zinc binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_02556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807270.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02556"/>
    <dbReference type="EnsemblBacteria" id="ACU08986">
        <property type="protein sequence ID" value="ACU08986"/>
        <property type="gene ID" value="FIC_02556"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02556"/>
    <dbReference type="eggNOG" id="COG2032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_8_2_10"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015673at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668725" evidence="4">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="5">
        <location>
            <begin position="36"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="167" mass="17647" checksum="5B62B3A95D14A93B" modified="2009-09-22" version="1">MKIATISTLLFGSALALSCGTTKNLVIEPKSGTDTQGTAKFTQQGKNVELDLNVYKLTPGAHAVHIHEKGDCSAADASSAGGHWNPTTESHGKWGHDQHHKGDIGNLNANQQGTARIVFKTDQWCLGCGDETKNIVGKSLVIHAAEDDFKTQPTGNAGGRVGCIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K3</accession>
    <name>C6X3K3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00533"/>
    <dbReference type="EnsemblBacteria" id="ACU06991">
        <property type="protein sequence ID" value="ACU06991"/>
        <property type="gene ID" value="FIC_00533"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00533"/>
    <dbReference type="eggNOG" id="ENOG5033JZ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144071_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="153" mass="17126" checksum="505B8086C308F7D0" modified="2009-09-22" version="1">MNLTPNKILKMKYTVVGLFESQNQAKELSAELEFSGVKHEDYIIYKTNRNSSPAQKQAFWKKVLGINKPAQSTEDDKLITSVAVYSDAELQEVKDTFAQNAAVKIYEFKDMSIDQAKDLDYIKKIVALRAKSHIYAMPAVSVSTGNISEGSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3K9</accession>
    <name>C6X3K9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782144.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00539"/>
    <dbReference type="EnsemblBacteria" id="ACU06997">
        <property type="protein sequence ID" value="ACU06997"/>
        <property type="gene ID" value="FIC_00539"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00539"/>
    <dbReference type="eggNOG" id="ENOG5032R1W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162562_0_0_10"/>
    <dbReference type="OMA" id="KQFGVWM"/>
    <dbReference type="OrthoDB" id="1881173at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="125" mass="14021" checksum="FE0C50961AF8DB89" modified="2009-09-22" version="1">MSDKKLAGLWLDGNKAVVVKNHDAQNAFKFFLCSPVKATVQHGNSNENTGNNAEQTNKIKFFKEIAHLLTNSEEVYITGPGQIQEELKSYLHDTPQFKNLKLTLDTAQQMSDEQVLEAVKSHFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3U4</accession>
    <name>C6X3U4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07082">
        <property type="protein sequence ID" value="ACU07082"/>
        <property type="gene ID" value="FIC_00627"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00627"/>
    <dbReference type="eggNOG" id="ENOG5033UT7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101906_0_0_10"/>
    <dbReference type="OMA" id="THEMAEN"/>
    <dbReference type="OrthoDB" id="1210950at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="285" mass="33094" checksum="C053E0D07CB3457B" modified="2009-09-22" version="1">MLKDRQRMKRINQIVLTILMVSLLTSCDFIKNSFTYKDKTKDFVETLIKEDYTKCVDQMAMTHEMAENTNIDTMKIGLANFRQLIVNNWGTELEYSFMKSEKKFSTVEADNTPPNTTLALIEFNNKKEFGVLEVLFDDKSQKILNIKTLDVKAPIPTMTYFWLFGLLAICIPIFNIYVIRQIKRSDLKKKWLKYIAVIFLNTPAITYAAVSGLSFKLINLQILLGVSFGYMGFLNSYWTFGIPLGGLYWFWKLRQQKNEVTETELTTDQNINTEPIIDNDKPTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y1</accession>
    <name>C6X3Y1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ordered locus">FIC_00664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782265.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00664"/>
    <dbReference type="EnsemblBacteria" id="ACU07119">
        <property type="protein sequence ID" value="ACU07119"/>
        <property type="gene ID" value="FIC_00664"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00664"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_10"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="176"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="436" mass="49623" checksum="68B2C9D81A489167" modified="2009-09-22" version="1">MSNIVAIVGRPNVGKSTLFNRFLERREAIVDSTAGVTRDRHYGKSDWNGVEFTVIDTGGYEVNTEDVFQEEITKQVQLAVDEATSIIFMLNVQDGLTDTDQDIYEMLRRSNKPVYVTINKVDSATDELAATEFYQLGIEKYFTLSSATGSGTGELLDAIVNEFPTTEYKDPFEGLPKITIAGRPNVGKSTLTNALLDKQQNIVTDVAGTTRDSIQTLYNKFGHEFVLVDTAGMRRKAKVKEDLEFYSVMRSIRSIEYSDVVIIMVDATLGWESQDMNIFGLAQKNRKGIVIVVNKWDLVEEKHTNTTRDFENEIKERIGQFTDIPILFISALTKQRILKSVEVAMEVYENRAKKIKTSKLNEVMLPVFEHTPPPAIKGKYVKIKYCVQLPTPSPQFVFFCNLPQYVKEAYKRFTENQLRKHFGFTGVPIEVYFRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z6</accession>
    <name>C6X3Z6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Possible ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782280.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00679"/>
    <dbReference type="EnsemblBacteria" id="ACU07134">
        <property type="protein sequence ID" value="ACU07134"/>
        <property type="gene ID" value="FIC_00679"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00679"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_28_3_10"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="218"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="380" mass="42576" checksum="FB732078D1D79B19" modified="2009-09-22" version="1">MSFESLGLSHNIIKSVRKLGFLKPFPVQEQTIPVILSGKDLMGVAQTGSGKTACFVMPILDKLQNEDIKKDRNIQVLVLAPTRELVIQIDEVFRVFTENLKREIRTMAVYGGVSINPQMKGMLGVEVLVATPGRLLDLIDHKALSISQITHLVIDEADKMFQLGFEEEMNTLFAMMPPKKQTVLFSATLNDKVEEIKQRLTIEPVLVEIKQEEVDIDQITQIAYHVTNESKGPFLRYLIKEQDIKQALVFASSTRSADHLAEKLNKNKIPATAIHGQKSQGSRSGNLQGFKEGETQILVATDLIGRGIHIDALEVVINYELPRSPLDYIHRIGRTGRANGHGTAITLLTDDELQHFRVIQKKMGKRVELIRTGDINLHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X402</accession>
    <name>C6X402_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782286.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00685"/>
    <dbReference type="EnsemblBacteria" id="ACU07140">
        <property type="protein sequence ID" value="ACU07140"/>
        <property type="gene ID" value="FIC_00685"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00685"/>
    <dbReference type="eggNOG" id="ENOG5032V4E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122746_0_0_10"/>
    <dbReference type="OMA" id="DIHEHEE"/>
    <dbReference type="OrthoDB" id="1441473at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="186" mass="20514" checksum="D4A932B7F39D8C1D" modified="2009-09-22" version="1">MKNILKISFIVLVATLLFSCRNNDDIPQDIHEHEEIEKLVVTVANVNTPADKQTVNYIGGVADGKFFLLAGETYSVALDFQVRHDDHYHSVNDEIIEERDEHFVTYEFAGSDIAVRRAADDVVRTDGNKIGLRTEWTVNSVTGQGNAAIKLVHGSTSVQQNFPSELNQQGKTTGGETDVNANIGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X413</accession>
    <name>C6X413_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2147 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782297.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00696"/>
    <dbReference type="EnsemblBacteria" id="ACU07151">
        <property type="protein sequence ID" value="ACU07151"/>
        <property type="gene ID" value="FIC_00696"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00696"/>
    <dbReference type="eggNOG" id="COG4731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108869_0_1_10"/>
    <dbReference type="OMA" id="CTDARKD"/>
    <dbReference type="OrthoDB" id="1848240at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019223">
        <property type="entry name" value="DUF2147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09917">
        <property type="entry name" value="DUF2147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970641" description="DUF2147 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2147" evidence="2">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="139" mass="15485" checksum="BF343F7917FC1366" modified="2009-09-22" version="1">MKKIMFAFVALFCATMSYAQIEGKWKTIDDETGQAKSIVEIFKKSDGKYYGKVTQLLIKPAVATCVDCKDDRKGKPILGMEVVRGMKKEGATFTGGTITDPKTGKTYKCNIERNGDKLDVRGYVGFSLIGRSQTWHKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X420</accession>
    <name>C6X420_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminodeoxychorismate lyase</fullName>
            <ecNumber evidence="1">4.1.3.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.38" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00703"/>
    <dbReference type="EnsemblBacteria" id="ACU07158">
        <property type="protein sequence ID" value="ACU07158"/>
        <property type="gene ID" value="FIC_00703"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00703"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_2_0_10"/>
    <dbReference type="OMA" id="MIAFESQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="266" mass="30907" checksum="751CB7F478AA7554" modified="2009-09-22" version="1">MDHFQFHSGDFQPHNRAFLHGDVVRVSFFVREAKLIMAEESYFFLMASMRKMRMNIPLSYTLEFFEQLLSAKVLSNGISEAVVTLHVYRGFGPALEKAEVSFFAEIKLGDVLQIREAIEMDLVKEINVNTNLLSNIRVHCPENIYAEIYARENDLDDVILLNPNRRIARSIYGNLLFLQDHVIKIPKQSEGAYISPLMENLVTFLHKKQLAEIQEVEMIAFESQKADEILMLSDEKGIFPLRKIRNKTFDFERFSGFVEQWRSSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>C6X424</accession>
    <name>C6X424_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="14" type="ordered locus">FIC_00707</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782308.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00707"/>
    <dbReference type="EnsemblBacteria" id="ACU07162">
        <property type="protein sequence ID" value="ACU07162"/>
        <property type="gene ID" value="FIC_00707"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00707"/>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115305_2_0_10"/>
    <dbReference type="OMA" id="MLYSKIH"/>
    <dbReference type="OrthoDB" id="1751990at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5014006418" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014006421" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU07162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="116" mass="13041" checksum="687FD2BA4A5E53B6" modified="2009-09-22" version="1">MLIEVFKSKIHRVHVTESDLNYIGSITIDEDLLEASGIIVGERVFIVNVNNGERFDTYAIKGKRKSGEVCLNGPAARRVQKGDIIIIIAYAQMTPEEAQHFQPKIIFPDEKTNLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X430</accession>
    <name>C6X430_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00713"/>
    <dbReference type="EnsemblBacteria" id="ACU07168">
        <property type="protein sequence ID" value="ACU07168"/>
        <property type="gene ID" value="FIC_00713"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00713"/>
    <dbReference type="eggNOG" id="ENOG502ZAPK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808304_0_0_10"/>
    <dbReference type="OMA" id="EMMPQEM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046230">
        <property type="entry name" value="DUF6263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19777">
        <property type="entry name" value="DUF6263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="356" mass="38664" checksum="28A04C796A5E5F2D" modified="2009-09-22" version="1">MKNHWMKNFTAIALIAIALVSCKKETKTITKVDPETGKTITVEVPVEDSAQAATAVMQEAAIKDSLGVYRQSFKLKVGSTYPLTTYQKDVQTMTAPDGKAQSGTSESTDEMTFTVNKFENGVYDITINLLAKKNSQAANGKTISVDTKQAEPKEEQLKMMYKVNKALVGNKLSLKMKENGEVVSITGFDPIYTKVTAAAGSLIKDAKQKTAFTQSFKESFNERILKDQFTKNLLLIPAKGVKLGEKWTQSENATPDGKVKLSTTYTLKSVDNGVAVITVAGGIPKKSDKKTQEGITRSMSSELTQNGTVTLDQMSGWIKNQTIAVKTSQSETLSDGKQSQTMKSVSNSTVVVNPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X439</accession>
    <name>C6X439_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782323.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00722"/>
    <dbReference type="EnsemblBacteria" id="ACU07177">
        <property type="protein sequence ID" value="ACU07177"/>
        <property type="gene ID" value="FIC_00722"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00722"/>
    <dbReference type="eggNOG" id="ENOG5033108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123239_0_0_10"/>
    <dbReference type="OrthoDB" id="1945089at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972285" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="247" mass="25648" checksum="C5F035CA8701D96F" modified="2009-09-22" version="1">MKKFYSLFAAVVLAVMVSAQGSENLDSRPTTAGTSYTTVNFTGEDATSWAFATTRIVDTSANYNISGTSALLNSNGTATITFANGLGTLNFQYRKAFTGGAARTVQVSVDGVIVNTSPAFGSGSGAQADVYDYSLLINKSGSVVVEVKVLGAQTTLDNFSWTAYDSTLAVGDVNATKANLVKNTVVANTILFAAKADVQILSMNGQVVKTASVDENTAMDVSSLAKGIYIVAGTVNGKAVSQKIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X448</accession>
    <name>C6X448_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782332.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00731"/>
    <dbReference type="EnsemblBacteria" id="ACU07186">
        <property type="protein sequence ID" value="ACU07186"/>
        <property type="gene ID" value="FIC_00731"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00731"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_15_0_10"/>
    <dbReference type="OMA" id="DLDWIPR"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970644" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="171" mass="19776" checksum="461758D7AE74F76E" modified="2009-09-22" version="1">MKQLFTVLSLFFALSVFGQKVPQINKTEFSKTSLAQKITSQTGTKLSVGEVLKKHEGKILIIDFWASWCQDCILALPATKELKENNPEVEFVYFSLDRSHEQWNRGLAKYGIDAEENYWFDEGWKNSFNNFIELNWVPRFIVVDQRGAIADYYAVSPSDPELLETIKKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X449</accession>
    <name>C6X449_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782333.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07187">
        <property type="protein sequence ID" value="ACU07187"/>
        <property type="gene ID" value="FIC_00732"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00732"/>
    <dbReference type="eggNOG" id="COG5587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036742_2_0_10"/>
    <dbReference type="OMA" id="YKTHQGA"/>
    <dbReference type="OrthoDB" id="1258218at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02453">
        <property type="entry name" value="TIGR02453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="223" mass="25740" checksum="446995F5AA960F53" modified="2009-09-22" version="1">MPVTINSSTLQFLKDLAHNNNREWFADNRERYIAANTNVAAFVEDLIDEIGLFDEEILKLDARKTLFRIYRDTRFSLDKTPYKTNFGAGLGFKRGNGSAGYYLHIEPGKSFLAGGLYQPQRDALREVRKEISMNKTEFIEILEKDEFRNNFRGLSVEHKLTRVPNGFEKDDPMAEYLKLKSFNVSHPVSDEVLMNENAAQNFAFIFKSMKPLNDFLNRPLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>C6X464</accession>
    <name>C6X464_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="9" type="ordered locus">FIC_00747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782348.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00747"/>
    <dbReference type="EnsemblBacteria" id="ACU07202">
        <property type="protein sequence ID" value="ACU07202"/>
        <property type="gene ID" value="FIC_00747"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00747"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_10"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU07202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="428" mass="47825" checksum="8CCA2181D5F33087" modified="2009-09-22" version="1">MSTYVVVGLQYGDEGKGKITDVLSAKSDYVVRFQGGDNAGHTVYAGEEKFVLHLLPSGVLQCKGKCIIANGVVVNPKAFLKEIGQIEEKGMRTDHVFISRRAHVIMPYHILLDTYREEETGGTFIGTTKKGIGPCYEDKIARVGIRMVDLLNPDVLAEKIRKNLKIKNSLFEKYFEKPTLEFDQIYNEFLELGEKLKDRIVDTEVELNEAIRDGKNILFEGAQAAMLDIDFGTYPFVTSSSPTTGGVCSGAGVPPTSLKNLIGVAKAYTTRVGEGPFPTELNDDLGEKIRKIGFEFGATTGRPRRTGWLDLVSLKHATMINGINNLVITKLDVLSGISPLKIATKYKTEDGKIIDYFTSSTTKLYNYEPVYEELEGWEEDITHARTYDELPQNAKKYIEFIENYLGINVYLVSVGPERSQNIIRKELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X473</accession>
    <name>C6X473_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Secreted subtilase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782357.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00756"/>
    <dbReference type="EnsemblBacteria" id="ACU07211">
        <property type="protein sequence ID" value="ACU07211"/>
        <property type="gene ID" value="FIC_00756"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00756"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022359_0_0_10"/>
    <dbReference type="OMA" id="WNFLGDA"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973444" evidence="6">
        <location>
            <begin position="19"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="275"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="566" mass="62176" checksum="3E2BF8840A354BDE" modified="2009-09-22" version="1">MKRILIAAYFLAGFAAFAQTDTKATDPMQDKDLMTWYHKDFASANVYGVNTDNAYKYLESKGLKAKPVIVGVLDSGVEVDHPGLIKNMWKNPNEVPNNGKDDDGNGYIDDIHGWNFIGGKNGDIDIDNMEVTRVVKKYQSVFEGPDSASNKANQAKMPEEFAMYMRSKEIFTKKSIEARQSFETYSMIQKNIPSMIALLNGQNLTPEAVAAIKPTTQEQAMASSILAQVVRDPSVQGKSPAEVQKFLEGQMKEAIDYYGPQANKQYNLDFDPRAEIVGDNYDDYSQKKYGNNNYEGPDAQHGTHVAGIIAGVPHGTEPQYGVGYKTAKIMTVRTVPNGDERDKDVANSIRYAVDNGAKILNMSFGKPVSPGRNVVWDAFKYAEDKGVLLVKAAGNENEDISEHTYYPSNFKDAKDEKAFISNMVVVGASTNDNEFLRANFSNYNQKMVDVFAPGDKIYSTVPDGKYEYLQGTSMASPVVAGAASVLLAYMPNLTPQQIIDSLVKTSNKSSVNAMIASNTNNRFDLISKAGGVIDVRKAAEYAFTNFYKAGAASKPAPKAKKKAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X478</accession>
    <name>C6X478_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier protein] reductase paralog</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782362.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00761"/>
    <dbReference type="EnsemblBacteria" id="ACU07216">
        <property type="protein sequence ID" value="ACU07216"/>
        <property type="gene ID" value="FIC_00761"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00761"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_10"/>
    <dbReference type="OMA" id="ARRANFI"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="241" mass="27224" checksum="59C79C9F03F9D7DA" modified="2009-09-22" version="1">MIILGSNSEVAQAFVEKVLDEGEKFSTIFLFTSNRETTEKFAKHIDVKYLQQSEIFDLDLMKELDYASFDHLTSNLLFCATGFLGEGTNEGLYNAKNTEKIIEINYAKLVQVLTFFAEKMERQRSGTMIVLSSVAGDRGRQSNFIYGSAKAGLTAYLSGLRNYLFSRKVHVMTVKPGFMATKMTEGLPLNPKLTASPKQAAEAIYSAYKKQKNVAYVLPIWSIIMMVIRNIPEFIFKKMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4F9</accession>
    <name>C6X4F9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine biosynthesis bifunctional protein HisB</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Histidinol-phosphatase</fullName>
                <ecNumber evidence="9">3.1.3.15</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Imidazoleglycerol-phosphate dehydratase</fullName>
                <shortName evidence="9">IGPD</shortName>
                <ecNumber evidence="9">4.2.1.19</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisB</name>
        <name evidence="10" type="ordered locus">FIC_00844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the histidinol-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="9"/>
    <dbReference type="EC" id="4.2.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782443.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00844"/>
    <dbReference type="EnsemblBacteria" id="ACU07297">
        <property type="protein sequence ID" value="ACU07297"/>
        <property type="gene ID" value="FIC_00844"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00844"/>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_0_0_10"/>
    <dbReference type="OMA" id="PEDTFWP"/>
    <dbReference type="OrthoDB" id="1278103at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01022">
        <property type="entry name" value="Bifunc_HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020566">
        <property type="entry name" value="His_synth_bifunc_HisB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005954">
        <property type="entry name" value="HisB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01261">
        <property type="entry name" value="hisB_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Histidinol-phosphatase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Imidazoleglycerol-phosphate dehydratase" evidence="9">
        <location>
            <begin position="174"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="364" mass="41438" checksum="26DEEF67CF419BCA" modified="2009-09-22" version="1">MKKVLFIDRDGTLIIEPPEDFQIDSLEKLEFYPKVIQNLAKIYNELDYELVMVSNQDGRGTASFPEDDFIKPHNKMLKTLENEGILFKDILIDSSFEEDNSPNRKPRTGMLQKYIYGGYDLENSYVIGDRQTDLELATNLGCKAIYLSETPDAVAELSTTDWSDIYSFLKSKPRKGVVRRTTKETDVLVELNLDGSGNSQIRTGLAFFDHMLEQIARHGNFDLKILVNGDLQVDEHHTIEDTALVLGSCFKQALGIKKGIERYAFLLPMDDCLAQIAIDFGGRNWLVWDVDFKRERIGDVPTEMFYHFFKSFTDTADCNLNIECRGDNEHHMVESVFKAFAKVLRDAVKVGGQNFSIPSTKGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H1</accession>
    <name>C6X4H1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782455.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00856"/>
    <dbReference type="EnsemblBacteria" id="ACU07309">
        <property type="protein sequence ID" value="ACU07309"/>
        <property type="gene ID" value="FIC_00856"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00856"/>
    <dbReference type="HOGENOM" id="CLU_2897559_0_0_10"/>
    <dbReference type="OrthoDB" id="2099818at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="62" mass="6967" checksum="50422CAB98201B96" modified="2009-09-22" version="1">MNPEKQTKKGPPAEVRKQNQDLPNIPASSEKIHSGEKAKKEIKESSKLHKDGKTESQDQNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4H5</accession>
    <name>C6X4H5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782459.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00860"/>
    <dbReference type="EnsemblBacteria" id="ACU07313">
        <property type="protein sequence ID" value="ACU07313"/>
        <property type="gene ID" value="FIC_00860"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00860"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006954_0_0_10"/>
    <dbReference type="OMA" id="SYDVDYK"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973454" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="651"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="744"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1058" mass="111226" checksum="C2C46C0C42E09D36" modified="2009-09-22" version="1">MKTKLLSFAFAAVAGLTFGQTGSLWTQTARPAQSEVLGNKVSIQAPKLFQLNIDGLKSALKNAPKKLAADEKSGKIITFPSSEGMMEDFKVSEHSNFEPALAAKYPDIKSYVGQSLADPSKIIYFSVSPLGLSSMEIQADNSAVFIEPYTTDASTYVVYKRADKKDNLSKFECTTIDEVRAQTDLTARPNADDGFLRTFRLALSCTGEYAVYFGGSKAQALAAMNNTMTRVNGVFEKDFSVRMVLIANNDAVIYTNASTDPYSNSSSMSQWNNQLQSTLTSVIGEANYDIGHLFGASGGGGNAGCIGCVCVNGSKGKGITSPADNIPAGDNFDIDYVAHEMGHQFGGNHTFTQSNEGTGVQMEPGSGSTIMGYAGITSVDVQPHSDPFFHAVTIQQITNNIKTKTCPVNTPTGNSIPTASAGSDYTIPKSTPYMLTGTSTDANGDALTYIWEQMDNQSTSAAPSATKTTGVNFRSWIPSTSPTRYFPRMQSVLAGATTTAGQEVTVEALSSVARNLNFRFTVRDNRPGGSGNNSDDAVITVNSTAGPFTVTSQTSAVTYSGGSSQPVTWNVAGTTANNINAANVDILWSTDNGNTWTTLLAGTPNDGSQNVTLPNSATTNGRLMVKGSNHVFFNVNKGNITVTAGTSDTQAPTAPTLSATGTTQNSTTLSWSGATDNVGITGYEVYRGSTLLGNTTAATYTVSGLAASTTYAFTVKALDAAGNSSIASNSVSVTTLAPANDTTAPTAPSLATSGTTSSSTNLSWNGASDNVGVTGYDVYQNSALIGSTSSTSYSITGLAASTNYSFTVKAKDAAGNISAASNSVSVTTLSSSVTYCTASATNTADERIGNVKFGTINNSSTGTAGYEDFTNVTTNVTRGTSYQISVTPTWTSTKYKEAYAVYIDYNGNGVFTDSGEKVWTKSATTTSPATGTVRIPTTAKVGSTRMRVMMQYNAIPSSPCGTFTYGQVEDYTLNIVSANKEMDRVPTPSADMRIYPNPLRGNILNVANADSSDYRIFDMSGKLIGSGTISGQQINLNQLTKGVYIIQVGKTSKRFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I7</accession>
    <name>C6X4I7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00872"/>
    <dbReference type="EnsemblBacteria" id="ACU07325">
        <property type="protein sequence ID" value="ACU07325"/>
        <property type="gene ID" value="FIC_00872"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00872"/>
    <dbReference type="HOGENOM" id="CLU_2751906_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="70" mass="7662" checksum="1CB1D2DFCB8FB98D" modified="2009-09-22" version="1">MKFSNLGNCLGFSAQLRKGWKQHPFIVCGGFAAANNKRYSGQPGPSEGMEVARPKAVQPERLNEGTRPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4K6</accession>
    <name>C6X4K6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin reductase</fullName>
            <ecNumber evidence="1">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782490.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00891"/>
    <dbReference type="EnsemblBacteria" id="ACU07344">
        <property type="protein sequence ID" value="ACU07344"/>
        <property type="gene ID" value="FIC_00891"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00891"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_10"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="314" mass="33653" checksum="FA8CFA2F68C28D06" modified="2009-09-22" version="1">MEQNILDCVIVGSGPSGYTAAIYAARADLKPELYTGLEPGGQLTTTTEVDNFPGYPDGVTGPVMMMDLQKQAERFDTKVYYEMITKAEFATEAGGIHKLWAGNKEIFAKTVIISTGATAKYLGLDDEKKYAGGGVSACATCDGFFYKGKDVVVVGAGDTAAEEATYLAKLTNKVTMLVRKDAFRASKAMVHRVNSTPNIEVKFNHELIAIEGENALVERAVVINNQTQETSKIDVHGIFIAIGHKPNTDIFAGQINLDENGYIKTIPGSTLTNLPGVFAAGDVQDHIYRQAITAAGSGCMAAMDAEKYLAELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4L1</accession>
    <name>C6X4L1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00897"/>
    <dbReference type="EnsemblBacteria" id="ACU07349">
        <property type="protein sequence ID" value="ACU07349"/>
        <property type="gene ID" value="FIC_00897"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00897"/>
    <dbReference type="eggNOG" id="ENOG5033D63">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836006_0_0_10"/>
    <dbReference type="OMA" id="NTRIMYV"/>
    <dbReference type="OrthoDB" id="1585031at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="343" mass="36847" checksum="6255FD13B5A1068C" modified="2009-09-22" version="1">MSFFLSLLKHTTMKKNLFILIACGSALSAQTVITKAFHDPIIGESAGYFTVNGTVDNSATGAGVTFSNGSLTQGTLTTTSYAAPTATELLAFPGSTIKMTAAGNTILYRQTATKLEITGLTASDVTLNFLANNGTVITYPAGFGYTETDQAQGTFTSSLASGLFRGTITNTADASGTLIVGTNTYGNVLRIKSVQSFNLHQSVDTFFLFPIGTITNTTFTYYNNTRKFPLLTYTSANISVPLLGINQSSESAQVLSDVFLNTASQAARAKIKIFPNPARETIQFSGDVSKYTQARIYNRDGKLIKTSDMKSEKIQVSELLPAAYLIEFSGKETQPQTVKFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R7</accession>
    <name>C6X4R7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782551.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00954"/>
    <dbReference type="EnsemblBacteria" id="ACU07405">
        <property type="protein sequence ID" value="ACU07405"/>
        <property type="gene ID" value="FIC_00954"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00954"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148655_2_0_10"/>
    <dbReference type="OMA" id="VWMLFFD"/>
    <dbReference type="OrthoDB" id="2063332at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="117" mass="14312" checksum="EDCED35CEEBF3ED4" modified="2009-09-22" version="1">MKDLIKDIKPKSPAFRRMRKYMLNKYAITIALFLCWMVFFDSTSFLVINEMNGEIKKYEKQLAYYKEEYKKNDDFFRKLMNDKQEKEKFARENYFMKKPNEEIFILVVDSSNLKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y3</accession>
    <name>C6X4Y3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782617.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01021"/>
    <dbReference type="EnsemblBacteria" id="ACU07471">
        <property type="protein sequence ID" value="ACU07471"/>
        <property type="gene ID" value="FIC_01021"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01021"/>
    <dbReference type="eggNOG" id="ENOG502Z8F9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188462_0_0_10"/>
    <dbReference type="OrthoDB" id="1972507at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="25345" checksum="FDEFA6D4CE8F9A3D" modified="2009-09-22" version="1">MAELKGVLKITGKLGGLSFYEMNGKIIVRTPGGFDGEKIRNDAKYVNVRNNAAEFGRCSKFGGRLRRALQPFVKDLNDHQIHGRMAKMLHQVMKHDKQSEKGKRSVLCGLQAMEGRAELARFVWNQREGNNCRYNFEKRMLYFDHIPAGSTQALVTLRFIHPDGGEGSLEYLETIFEVVLPCAEFSVPEHACFADVEEGMLRFALIRFYDAKGELLSGRTAVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X560</accession>
    <name>C6X560_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01098"/>
    <dbReference type="EnsemblBacteria" id="ACU07548">
        <property type="protein sequence ID" value="ACU07548"/>
        <property type="gene ID" value="FIC_01098"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01098"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198345_0_0_10"/>
    <dbReference type="OrthoDB" id="1048840at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="162"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="231" mass="27095" checksum="ABE236EB90C88841" modified="2009-09-22" version="1">MSQKEYYEIGKNKNLPIRCPILNYCSRRAFTIYFNSDYDKYDAGQNVQEALLKDGTLPSDFESKKIDIQGEAPTWIKGNSSYCFSGMCPEVNLFDAMNSLFKDEACVSAEYDKYYTEPKHRVLKTQHYSECPEFNFYNFEKGRKKVSESKPRKTISYKIRSILQKEIKSVCPFCYNEDVEHFHVHHIDENPANNKIDNLLMLCPNCHSKITKGDIKYEEVITMKRNLNKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B2</accession>
    <name>C6X5B2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805885.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01150"/>
    <dbReference type="EnsemblBacteria" id="ACU07600">
        <property type="protein sequence ID" value="ACU07600"/>
        <property type="gene ID" value="FIC_01150"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01150"/>
    <dbReference type="eggNOG" id="COG5579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124534_0_0_10"/>
    <dbReference type="OMA" id="WFVFPQI"/>
    <dbReference type="OrthoDB" id="1625285at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014937">
        <property type="entry name" value="DUF1810"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036287">
        <property type="entry name" value="Rv1873-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08837">
        <property type="entry name" value="DUF1810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008546">
        <property type="entry name" value="UCP008546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140736">
        <property type="entry name" value="SSF140736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="147" mass="16430" checksum="9930AA7E726EE8A3" modified="2009-09-22" version="1">MNLQRFVGAQEGVYETAVEELQSGRKKSHWMWFVFPQLKGLGKSSTAEHYGIADLAEAKAYLEHPVLGARLREITAILLHLAVTDARAVFGTPDDLKLKSCLTLFAQVNPTEHTLFHEALELWFNGNSDVNTLELLYGKPGFRTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B9</accession>
    <name>C6X5B9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805892.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01157"/>
    <dbReference type="EnsemblBacteria" id="ACU07607">
        <property type="protein sequence ID" value="ACU07607"/>
        <property type="gene ID" value="FIC_01157"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01157"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_6_1_10"/>
    <dbReference type="OMA" id="PWYGIGR"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="226" mass="25165" checksum="169236237025BC5C" modified="2009-09-22" version="1">MEVIQSVLDFFLNLDKHLFTMIVDYGPWIYLILFLIIFVETGLVVMPFLPGDSLLFAAGTFCAGVIGASGEVASLNLWLVLALLFVAAVLGDSLNYYLGKNIGLKILGWKIGEKQLVNPKYIAQTQEFYQKNGPKTIIIARFVPIVRTFAPFVAGIGSMNYGTFIKYNIIGGFVWVFGLTLLGYFFGNMPIVQENFETVIIGIIVISVLPMIWEFISAKLKKNKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C4</accession>
    <name>C6X5C4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805897.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01162"/>
    <dbReference type="EnsemblBacteria" id="ACU07612">
        <property type="protein sequence ID" value="ACU07612"/>
        <property type="gene ID" value="FIC_01162"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01162"/>
    <dbReference type="HOGENOM" id="CLU_2422599_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="91" mass="10622" checksum="C5B0B0D9BCD7E6D8" modified="2009-09-22" version="1">MKIEIQENEINLLRLGQSHGEAEVVKREIFFEVQGKEYACDVILDRNNTGAEYDSPENFYMMNKEMVDAALITFLSEKHLYNNMDSDREAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H8</accession>
    <name>C6X5H8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01218"/>
    <dbReference type="EnsemblBacteria" id="ACU07666">
        <property type="protein sequence ID" value="ACU07666"/>
        <property type="gene ID" value="FIC_01218"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01218"/>
    <dbReference type="HOGENOM" id="CLU_1213348_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="228" mass="26346" checksum="DBEDC69A0662CE2B" modified="2009-09-22" version="1">MNFCAKLKICASITPPSQSPGTLHESAYPKPNKTLMKRIYLIFLLIIAQTVFSQKDNRIENIGEATSQLLIKGDDIDNFKYAIKIQSLYPNEDFSKFKDSPAEVILNMLHGAELELPKAWNEVVKESGEYKIDKTSKYVFTYSHKMGVDNYIATSVIESQSKYYAFSYNLLQWGEDIYISRFYKKVMEFETVEQIDSNPFVIIHDEMQKELNEIDENHSEEILIGPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M6</accession>
    <name>C6X5M6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_M56 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805999.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01266"/>
    <dbReference type="EnsemblBacteria" id="ACU07714">
        <property type="protein sequence ID" value="ACU07714"/>
        <property type="gene ID" value="FIC_01266"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01266"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503216_0_0_10"/>
    <dbReference type="OMA" id="KMENGMT"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="3">
        <location>
            <begin position="162"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="541" mass="61744" checksum="E5217068345DEECD" modified="2009-09-22" version="1">METLMLYSVKVILCSAVMFLYYKFFLKDRTFHHYNRFYLLASMLISILLPLLKVSYFTLEVNSSIYLLFSSLGTLNSADTLNHDFIYFRFIILAVGAVSVFFLSRFITGLTKIQQLKSRFRHEEIEGINFYHTDLAEAPFSFFRNLFWKDSIPLHSDLGRQILKHEMVHIDQKHSTDKIVLEILTAVFWFNPVFHLIKKEINLIHEYLADKKAVKNSDTRAFAQMLLASHFSGKGLPATSPLLSSNLKKRLTMLKKSKTKYGYARKILALPLLFALAFIYLVNAENREIKMTNQEVEAYLFKMKSDTIPPPPVPEVAPLPAAAALPAEPAVPSVVPEVPEIPQETLKAMNKAAAKQSAEAQKISITLKKKSDELQKLANRKDFESPKFKALEKELNQLGEKLDAIYNTAEFKNVDQHYAKLDEHYNSDAFKATIKAAELAAAEAEKKVNSPEFKKKIKEAEQRAKEVEKQINTPEFQQKIKDAEARAQKAIDEKPVIYIDGILSGDTEMNELDPNRIAKMNVFKKGHGGKKNSEIWIETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P1</accession>
    <name>C6X5P1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806014.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01281"/>
    <dbReference type="EnsemblBacteria" id="ACU07729">
        <property type="protein sequence ID" value="ACU07729"/>
        <property type="gene ID" value="FIC_01281"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01281"/>
    <dbReference type="eggNOG" id="ENOG5032WMD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607943_0_0_10"/>
    <dbReference type="OMA" id="YIGNYAR"/>
    <dbReference type="OrthoDB" id="1722677at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="165" mass="18458" checksum="25913E5C9C807B4F" modified="2009-09-22" version="1">METKYNSLEELKRKKAILKKDVSEMEDLLTFDNTKQSLSAFTNGFTDKFLKEEVKPGGGTELKFDGSGIFKEFAENVKDSVLNKNTVRSIAANPGTVAMAENALKLGAVSYIGNYARKNLNNTSWKKKAIGLALIYVAPAVLKMVRERLENYQRNKTTSSMEHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X600</accession>
    <name>C6X600_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GATase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01390"/>
    <dbReference type="EnsemblBacteria" id="ACU07838">
        <property type="protein sequence ID" value="ACU07838"/>
        <property type="gene ID" value="FIC_01390"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01390"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007788_0_0_10"/>
    <dbReference type="OMA" id="ICHSFQL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="283" mass="33183" checksum="34A0338CC7FBBCBA" modified="2009-09-22" version="1">MHRNSIVMKEIKIALLNMNNNHPNQGMRNITEISEAFKEHSADRVSIDVFDVRYKDEMPDTADFDIFISSGGPGNPHREGHAWEQRYADFLDEIWANNMKSDRKKYLFLVCHSFQLACIHWKLGNVCERKSYSFGVMPIHKTYQGEDDFLLKNLPEPFYAVDSRAYQFIEPNHAVFEEMGMKIMGLEKMRPHIHLERAVMAIRFSNEIFGTQFHPEANPKGMLENLKDPKNRDAMIENYGMEKYLETVDRMDDPDKIVFTQSQILPRFLRHASEQIVKEFQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X639</accession>
    <name>C6X639_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical signal peptide-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806162.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01429"/>
    <dbReference type="EnsemblBacteria" id="ACU07877">
        <property type="protein sequence ID" value="ACU07877"/>
        <property type="gene ID" value="FIC_01429"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01429"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081300_0_0_10"/>
    <dbReference type="OMA" id="GWKVRPF"/>
    <dbReference type="OrthoDB" id="1915733at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970729" evidence="1">
        <location>
            <begin position="22"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="220" mass="25334" checksum="19A6C6E3D5377F2A" modified="2009-09-22" version="1">MKKAILVFILCIGGLFSAQTAKEIIDQNIELSGGLTNWKLLNSIIIQGKLTLGVNDQYPIKIYQQRPNLTKTVIVINKKETAVEGYDGKKGYAMNYATNKIQEYPNYSAESFDTDFIDWESKGFEAKYLGKEKVGEIYCHKVELTKNVNKTMYYFDAKSYMLLKEVQKDETLVYSDYRKIGSLMMPFRIESASPKKDSDYVMVINRIETNKVLPENTFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X690</accession>
    <name>C6X690_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806213.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01480"/>
    <dbReference type="EnsemblBacteria" id="ACU07928">
        <property type="protein sequence ID" value="ACU07928"/>
        <property type="gene ID" value="FIC_01480"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01480"/>
    <dbReference type="eggNOG" id="ENOG502Z848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650446_0_0_10"/>
    <dbReference type="OMA" id="HMENNYG"/>
    <dbReference type="OrthoDB" id="535406at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970733" evidence="1">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="453" mass="50396" checksum="1969B8E61A6892F2" modified="2009-09-22" version="1">MKTMLMRVSMLAVIFSAAGLQAQDNSSTMRDYLAPEKTTRDIFEDPKVAAPEYDGVKVSVGGDFALQFQALDHETTATLGPDYVLNTLGSDFNLPTANLDINAYLAKGVKMHLRTYLSARHHNEAWVKGGYIQIDNLDFISEGFMSSLMTDVRVKVGMDEINFGDAHFRRTDNAEAINNPFVENNIMDSFTTQAFGEVYYYKNGFMGMLGLSNGKLNQTATKGTNENAPSIYGKLAYDKQIDQDLRVRLSGSVIKTNGLNTNGKLYGDDRAGSRYYYPLLVTNTVNSALSDAMGANNAMTGRFDPNFKEMTAIQINPFVKYQGLEFFGTYEYVTGNKPLNATTLRDSDGTYNQYAGELLYRFGGKEQFYLGGKYNAINGKDYEGALERKIDRFNIAGGWFMTKNVLAKIEYVSQTYNESDVWNVLDASTPKQQKSPLSGGKFNGIMFEATIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X695</accession>
    <name>C6X695_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806218.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01486"/>
    <dbReference type="EnsemblBacteria" id="ACU07933">
        <property type="protein sequence ID" value="ACU07933"/>
        <property type="gene ID" value="FIC_01486"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01486"/>
    <dbReference type="eggNOG" id="COG1956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077738_2_2_10"/>
    <dbReference type="OMA" id="DNYIACS"/>
    <dbReference type="OrthoDB" id="1739746at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="16898" checksum="79AB216C5B130F3C" modified="2009-09-22" version="1">MSEIKKRLSIILESPNHDLNDKLQKVCHLLDQEIPYFNWTGFYFKNGDKDELILGPYVGAETDHTIIPFGKGICGQVAVSNETFVVPDVHDQDNYLSCSIDTKAEIVVPIIKNGENVGQIDIDSHTLNPFTAEDREMLEWLCDEIAKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B4</accession>
    <name>C6X6B4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytoene dehydrogenase</fullName>
            <ecNumber evidence="6">1.14.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806237.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01505"/>
    <dbReference type="EnsemblBacteria" id="ACU07952">
        <property type="protein sequence ID" value="ACU07952"/>
        <property type="gene ID" value="FIC_01505"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01505"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_10"/>
    <dbReference type="OMA" id="INYPKGG"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970735" evidence="4">
        <location>
            <begin position="18"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="489" mass="55571" checksum="170A52B71261D78A" modified="2009-09-22" version="1">MVKVLILGSGFSSLASACYMAKAGYDVTVIEKNEQIGGRASMLEIDGFKFDMGPSWYWMPDVFERFFADFGRKVSDYYSLEKLSPGYRVYFGKDDYIDISDDLEQIIETFEDIEPGSGQHLREFMKKAKANYEIAIEDLVYNPGKSVLELVNYETAKRLPLFVRNISETVRKNIRSPKLRSILEFPVLFLGAKPGDTPAFYNFMNHADFGLGTWYPKGGFNAVAKGIETLARELGVKFILNEAVTEIITENNSATKIITKNESYHADIVISGADYAHTETLLNKNQRNYSENYWQKKTFAPSSFLYYVAFDRKIPQLQHHNLFFDTDFGKHAEEIYDTKVLPTRPLFYANFSSKTDPGLSPEGMETGFFLIPVAVDLVDSKEIHDEYFELIMQRIEINTGMDLRSHVLFKKSFGVQDFTERYNSCRGNAYGLANTLLQTSVLRPSINNNKVKNLFYTGQLTVPGPGVPPALISGKVVTDYILKHINRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B7</accession>
    <name>C6X6B7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-carotene hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sterol desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01508"/>
    <dbReference type="EnsemblBacteria" id="ACU07955">
        <property type="protein sequence ID" value="ACU07955"/>
        <property type="gene ID" value="FIC_01508"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01508"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054855_1_1_10"/>
    <dbReference type="OMA" id="HKHLGKE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045019">
        <property type="entry name" value="BETA-OHASE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31899">
        <property type="entry name" value="PTHR31899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="20157" checksum="F5E398FA597F6B8E" modified="2009-09-22" version="1">MYAGSGNISKYSDMEILGFALITLAVFVGMEGVTWLTHKFIMHGLGWYFHEDHHQPGYPHVFEKNDFFFVIFATPSILLFYFGSRGELNWMFFVGLGILLYGICYFLVHDVLIHRRFKWFDKTNNWYFRGLRKAHKIHHKHLDKEDGECFGMLFVPMKYFREARSVPQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B8</accession>
    <name>C6X6B8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lycopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_01509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806241.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01509"/>
    <dbReference type="EnsemblBacteria" id="ACU07956">
        <property type="protein sequence ID" value="ACU07956"/>
        <property type="gene ID" value="FIC_01509"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01509"/>
    <dbReference type="eggNOG" id="ENOG502ZZTD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083013_0_0_10"/>
    <dbReference type="OMA" id="EWLFFIC"/>
    <dbReference type="OrthoDB" id="1912994at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18916">
        <property type="entry name" value="Lycopene_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene_cyc" evidence="9">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene_cyc" evidence="9">
        <location>
            <begin position="131"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="243" mass="29228" checksum="B6338F3FD4BA7924" modified="2009-09-22" version="1">MEQYYYLFLNILSFSVPFLFSFETKRMHFIRYWKPFFAAILIVGLFFIAWDVYFTHEDVWGFNDQYLIGLRIFKMPLEEYLFFLLIPYASVFIHYALEYFYPRMMLSQAVSNVISLVLFILSLAIAVFNYDKIYTVCSFGLFALLMLMQIIFKWNVIRRFYLSFIIIYIPFFFVNNALTGNYSENPVVFYDSAEIIGIRVGTMPLEDSFYCFTLLYSIVLLFEFFKNKWKYPPLKLNDADQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G2</accession>
    <name>C6X6G2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_01553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01553"/>
    <dbReference type="EnsemblBacteria" id="ACU08000">
        <property type="protein sequence ID" value="ACU08000"/>
        <property type="gene ID" value="FIC_01553"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01553"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_1_1_10"/>
    <dbReference type="OMA" id="EKATWTL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="124" mass="13030" checksum="FCD056F3C997CED9" modified="2009-09-22" version="1">MHFENFKNGMSTIFTLFMILIMILSILLVIIVMAQNPKGGGLSGTFGGTSSAQFGVQRTNDFMEKATWILGGSIVFLILLSVILTAKPSVSMKQQLPASTEAPAPQTAPGTNSTTTLPAAPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I1</accession>
    <name>C6X6I1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806304.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01572"/>
    <dbReference type="EnsemblBacteria" id="ACU08019">
        <property type="protein sequence ID" value="ACU08019"/>
        <property type="gene ID" value="FIC_01572"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01572"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_10"/>
    <dbReference type="OMA" id="GEGEKMP"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="590" mass="66241" checksum="DF5BCD5E593A45DF" modified="2009-09-22" version="1">MTIKRIFDFPKHALENYPREDMFVTKYNGVWEKTSTQEFHNMANKVSRGLLKLGIKPGDKISLITTATRTEWAIMDMGISQIGAVSVPVYPTISSDDYGFIFNDAEVKYCFASDRELLDKVLKIKSIVPSLQGIFTFDQIEGAANWNEVLDLGSDEASQNEVEDIANSINSEDLATLIYTSGTTGKPKGVMLTHHNIVSNVLASNSRIPRVKGLEYTDIKILSFLPICHIFERMLFYLYQYNGYSVSFAESIEKMGENIKEVKPHIMSVVPRLVEKVYDKIYDKGSSAGGLKAKIFHWALELNESKQNISKPSGLKEIIADKLVFKKWREGLGGNIITLVSGSASLSARLNKLFQNAGIPILEGYGLTETSPVISVNSFGKIKVGTVGHVLENLDVKIQEDGEITVKGPSVFKGYFKNEEMTKEAFTDDGYFRTGDIGHIDDEGYLHITDRKKEMFKTSGGKYIAPQVIENLAKASKFIEQIMVVGDGEKMACAFIQPDFNFAGHWAERKGYKIGTTPAEMAANKELKERIGKEIDLLNSKLGNWEQIKKFELTPEAWTIEQGVLTPTLKLKRKALKERYLDLYNQMYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I3</accession>
    <name>C6X6I3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806306.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01574"/>
    <dbReference type="EnsemblBacteria" id="ACU08021">
        <property type="protein sequence ID" value="ACU08021"/>
        <property type="gene ID" value="FIC_01574"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01574"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_6_10"/>
    <dbReference type="OMA" id="VCAYTEL"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="172" mass="19483" checksum="E32F38628AB83080" modified="2009-09-22" version="1">MKFPPYKTFPTLDNERVSLREIRSSDMEALVEISYYDAIKAEDAQQAAEMHAKINEDYFDGNSIHWGIADRATDCIIGTCGYYRGFENGRGELGCVLLPDFRGKGYMSDAMKLAVDFGLNTIGLKQIWAATDRTNIAAVKLLERVGFRKTAEREDGEVEYFLCVINHVEKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZC6</accession>
    <name>C6WZC6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein (Putative transcriptional regulator)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782107.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00502"/>
    <dbReference type="EnsemblBacteria" id="ACU06960">
        <property type="protein sequence ID" value="ACU06960"/>
        <property type="gene ID" value="FIC_00502"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00502"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_4_10"/>
    <dbReference type="OMA" id="FSKTCEY"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="144" mass="16373" checksum="3203D9CE0EE027A4" modified="2009-09-22" version="1">MFSKACEYGIKAAIYIAQQSQLNRTVNVKDVALSIDAPVAFTAKILQLLCREEILQSVRGKQGGFFFSEEKQRQFRIYDLVTRIDGDGLFTQCGLGLQRCSSENPCPVHNDFKIVRDRLFEMTSKHTFFDLALKTQSGLAWLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZD8</accession>
    <name>C6WZD8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00511"/>
    <dbReference type="EnsemblBacteria" id="ACU06969">
        <property type="protein sequence ID" value="ACU06969"/>
        <property type="gene ID" value="FIC_00511"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00511"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_6_0_10"/>
    <dbReference type="OMA" id="MQFGIEI"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="169"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="409" mass="47127" checksum="6FD942D424B61B1E" modified="2009-09-22" version="1">MCFFNLQTMQKNFLIITGITFILEFYVYQAFKTLTTNSWLRSAYWVITVITYAFFIYELLNFRRSDRDAQRIQIVASVFLIFMLPKLFVIFFLFLEDITRFFNYLFTFFARPESYYPERRKFVSLAALGIAGVFSALIIDGIVFGKYRHSVRRVKIKIPGLPAAFKGYKIVQISDVHAGSFLNPEKLQPAIDLIKAQNADLVLFTGDMVNNYAQEFKPFVQKFAGINAKDGKFSVLGNHDYGDYAEWLTKADKDRNIPLLTELQKQAGFELLRNEHRVIERGGEKLYLLGVENWGLKPFPQYGDLNKAAAGIPRDAAKILMSHDPTHFDEIVKKHPANIHLTLSGHTHGMQFGLDLKNVRWSPVQYRYKKWADLYESEGKLLYVNRGFGVIGFPGRVGITPEITLFELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZG1</accession>
    <name>C6WZG1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted DNA alkylation repair enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781643.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00018"/>
    <dbReference type="EnsemblBacteria" id="ACU06496">
        <property type="protein sequence ID" value="ACU06496"/>
        <property type="gene ID" value="FIC_00018"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00018"/>
    <dbReference type="eggNOG" id="COG4912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079880_0_0_10"/>
    <dbReference type="OMA" id="NWDLVDT"/>
    <dbReference type="OrthoDB" id="1933111at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="237" mass="27910" checksum="E4A2BB7398CD3CA3" modified="2009-09-22" version="1">MVVDAIKSALQDLSLPEKAAFYPRFFKAGKGEYAEGDIFIGVTVPDQRKVAKEFYAKISLEQLHDLLASPIHEYRHTALLMLVIKYEKSADTASKEEIVDFYIRNRKYINNWDLIDNSCYKILGRHAFETSNEDLLRTLAAEENMWSKRIAVVATMYYVKRDKFQLLKELVLLNLHHPHDLMHKANGWLLREMGNKNERELIDFLREHYDTMPRTTLRYAIEKLDENLRQDFLKGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZJ0</accession>
    <name>C6WZJ0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable Co/Zn/Cd efflux system membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781672.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00049"/>
    <dbReference type="EnsemblBacteria" id="ACU06525">
        <property type="protein sequence ID" value="ACU06525"/>
        <property type="gene ID" value="FIC_00049"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00049"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012669_0_0_10"/>
    <dbReference type="OMA" id="PEIAWNY"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972144" evidence="1">
        <location>
            <begin position="22"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="142"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="896" mass="99988" checksum="AA72485291B75C39" modified="2009-09-22" version="1">MKSLLKSLVAFSLLLTTTLSAQTITKSTFKVKGECGMCKERIETTAKNTGATYANWSADSQQLSLEFDPEKTTPEAILKKIAEAGHDNEQFTAPDAVYNDLPGCCLYERQPSFLKTSETPAANTKVANLPKKADNQFYVRGNCGSCKARIEKAAHTAGATAADWNTDTQTVTLLFDAAKTSADTILKKIADVGHDNEKYQATDAVYKQLPDCCLYDRELPLGVKSPLVHHEEETPARKDHTQHADHVDKSIEEVKLIRLGEATALNKKETGLTFNISSKELLKAACCNLSESFETNATVDVSFSNAVTGTKQLKMLGLDQKYTSLTKELLPSIRGLAAPYGMNLIPGRWIGGIQLTKGGSTVTNGYESITGQINTELLKLQDTPETAINFFGDLNGRFESNITSTSALSDHWNQTVLLHGNATLAKMDTNDDGFLDQPTGNQINAAYLLNYNDLEHSGLGTHFGISFVKDERFGGQTDFDKNTDRSQQSYYGVGIDISKFDIWNKTGYVFKGKPYQSIGLMNQFTYHQQDSFFGNRNYLGNQKTFYSNLIFESIFGNTNHKYKTGASFLYDQFDENYLTQSYQRTETVPGLFFEYTLTGLKYTLVAGARTDFHNLAGTQFTPRVNFKYDLSPKTILRLSAGKGFRTANIFAENQQYFASNRQIEILANGGNIYGLKPEIAWNYGASLQQEFKLFGRKSTLVADFFRTDFQDQVLVDLDVSPNKMVFYNLDGKSYANSFQTQLDFTPAKNLEIRLAYKYYDVQADYLGGKREIPFMAKNRGFFNASYATDKNEKDAFWSFDTTLQLVGRQKLPHLDGNPSEFQLPEYSASFATLNAQISRNVNKNIRVYLGGENLTSYTQDQPILDAANPFGNYFDAGMVYAPIMPANVYLGLDVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZK0</accession>
    <name>C6WZK0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00059"/>
    <dbReference type="EnsemblBacteria" id="ACU06535">
        <property type="protein sequence ID" value="ACU06535"/>
        <property type="gene ID" value="FIC_00059"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00059"/>
    <dbReference type="HOGENOM" id="CLU_2843424_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="65" mass="7140" checksum="F17874A96E12C0E1" modified="2009-09-22" version="1">MAEASEATKKMQRKAGGVVANCINTVAPKTTKMSKKKNQALKKEPDLYILWCFVIAFPGIKVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X009</accession>
    <name>C6X009_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="8" type="ordered locus">FIC_00220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781841.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00220"/>
    <dbReference type="EnsemblBacteria" id="ACU06694">
        <property type="protein sequence ID" value="ACU06694"/>
        <property type="gene ID" value="FIC_00220"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00220"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_6_2_10"/>
    <dbReference type="OMA" id="WQHILIV"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="66" mass="7362" checksum="4F8375DEFC95BB94" modified="2009-09-22" version="1">METLTILALSWQHLLIVAVVLLILFGGRKIPEMMRGLGSGIKEFKDAVKEEDKKPEEPKSNSNPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X014</accession>
    <name>C6X014_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781846.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00225"/>
    <dbReference type="EnsemblBacteria" id="ACU06699">
        <property type="protein sequence ID" value="ACU06699"/>
        <property type="gene ID" value="FIC_00225"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00225"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_7_2_10"/>
    <dbReference type="OMA" id="ETAFFRF"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="343"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="485" mass="55157" checksum="8057B68330F3ADCD" modified="2009-09-22" version="1">MYKKLLGQTALYGLTTVVIRLFPFIINPYITDAFGPQAYAPFADFYSVAGVIAVLLTHGMETTFFRFSLEEKNDKKLISTAFFSVAVATLLFLVLSLLFRNDLAVAFKTPTEVNLLTILVVILSLDAFSAMPFVMLRKNEKPLRYASVKITNGIINFALVVFFLQILPRLPDGIMGYRYNASFGIGYVFVANLVASAVTFILLFKDIFIAKLKYFSWELWRKMMKYSWPITIAGLAGIINETLDRQFLKFLLPEDIARYELGVYGAVAKLVTFVVLFRQAYVLGIEPFFFSHSKSENAGKTYAKLMDVFIAANCLIVLFLCINLDWISKFYLNNSAYYEGISILPVLFFASLFLGIYLNLSVWYKLSDKTLIGAYISVIGAAVTIGVNFWFIPEYGYWACAWATLASYFVMVTVSYIWGQISHPIPYNLYGNIVIILITIILSMVFYQHFKYDIWLGNIIFIVLAAVLIKVQRLIPQSLLDKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X029</accession>
    <name>C6X029_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperone protein HtpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00241"/>
    <dbReference type="EnsemblBacteria" id="ACU06714">
        <property type="protein sequence ID" value="ACU06714"/>
        <property type="gene ID" value="FIC_00241"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00241"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_3_2_10"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU06714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="653" mass="74519" checksum="5A622399BB1870CA" modified="2009-09-22" version="1">MPNCHYFGHGTLFEKRIQNKLTVMTKGNINVSVENIFPLIKKFLYSDHEIFLRELISNATDATLKLKHLTNIGEANVDYGTPQIEVKIDKEGKKLHISDQGIGMTTEEVEKYINQVAFSGAEEFLEKYKDSAKDAGIIGHFGLGFYSAFMVAEKVEILTKSYKDEPAVRWICDGSPEYSIEETTDKSDRGTEIILHIAEDSTEFLEESRIRELLMKYNRFMPVPIKFGTKTETLPLPEDAAEDAKPDTQDVDNIINNPTPAWTKTPAELKDEDYSNFYRELYPMQFEDPLFHIHLNVDYPFNLTGILFFPKLANNLNIEKDKIQLYQNQVYVTDEVKGIVPDFLMLLRGVIDSPDIPLNVSRSYLQTDGAVKKISSYITKKVGDKMASLINENREDFEKKWNDIKIVIEYGMISEDKFYDKSDKFALYPTVDGQYLLWNELEEKIKANQTDKDGNLVILYASNEHDQHSYVQAAKDKGYEVLLLDSPIVPHLIQKLEGSKEKIQFARVDADHVNNLIKKDEPVISKLNETEKETLKKTVEEGISDTKFTVQLEDLDSSDAPFIITQPEFMRRMKDMQATGGGGMFAMGGFPEMYNLVVNTNSELAGKILNNENADEKTTQIKHALDLAKLSQNLLKGKELTDFIQRSYQSLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X093</accession>
    <name>C6X093_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781925.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00311"/>
    <dbReference type="EnsemblBacteria" id="ACU06778">
        <property type="protein sequence ID" value="ACU06778"/>
        <property type="gene ID" value="FIC_00311"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00311"/>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061566_0_0_10"/>
    <dbReference type="OMA" id="NPSGYKK"/>
    <dbReference type="OrthoDB" id="1531747at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="179"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU06778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="351" mass="39147" checksum="6339EE5925DB317B" modified="2009-09-22" version="1">MLKSLFHWKVLVNILLAAVVFTGLVWLTFRWLELHTNHGKEIPVPNVMNKSVHDAIKILDDSGLDYEVDSFKFDPKFRPFQVLQIYPSPGSRVKDGRTIILKVNPRTYAQVSVPDVLDRYKGLAFRQLEQVGLKVGDTIFEPSIQRDAVLRMTYNGTTLKPGALLPRFSTIGLVIGAGPKRNISVPNLVGLTVQEAKAVIAQNLFEVGLVESEDGAQDESDIVYYQDPAPYDVRDQGMQIDIWASKKTPAEMGAKISQLNSIYRIKLEDVEPLPRFDDAPVYREPSPQPVEPKREIPRTEAPKAETPKTQPSATPKTTPDVKPKAPATNTSTKTTPAKTDEKPKARKVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X097</accession>
    <name>C6X097_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ordered locus">FIC_00315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00315"/>
    <dbReference type="EnsemblBacteria" id="ACU06782">
        <property type="protein sequence ID" value="ACU06782"/>
        <property type="gene ID" value="FIC_00315"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00315"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_0_2_10"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU06782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="31764" checksum="F7F7CC11233EACC8" modified="2009-09-22" version="1">MHKLLPLKKIKQDFSHLSPDQPIGIFDSGVGGLTVAKEIKRLLPNENLIYFGDTKHLPYGEKSRDAIVGYSTKITRFLLEKNCKAIVIACNSATANALKEVLDEVADRVPVIDVINPVAEKVAYEIHNNVGVIATKATVNSGLYRKSIRKHNKFIKVDELATPLLVPAIEEGFKNHPITHSIVYNYLSNNKLKNIETLILGCTHYPLLIDEIRQYYGNRVRVIDSPGIVANQLRIILDKHQLLNAKNSNTAYQFYLSDLTKNFEKISKKFFGNSIQLDLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0B5</accession>
    <name>C6X0B5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781947.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00333"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06800">
        <property type="protein sequence ID" value="ACU06800"/>
        <property type="gene ID" value="FIC_00333"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00333"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_10"/>
    <dbReference type="OMA" id="FACPCGP"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="181"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="362" mass="41219" checksum="C190B5A924AF88CC" modified="2009-09-22" version="1">MHIVYLTEQIDQVGGIERSLTTRANYLAEVFNYQITIVCTSRKSGKPAFKINDSINVLFLEKLTSRKTVYGRILLRFIQTKKIITELKPDVVISVKYTLHNLFFTLYPSRIRFISELREPFGQANQHVTSSLKSFISKKIRNFVLKRQDVVIVLTEEDKRNWGYKNIRVVPNPHTIQTDVVSDLSKKQVLALGRLHKVKGFDKLLEVWKIVNTAHPDWILKIGGAGEEYENLLAKIRFLGLNDSVILNNQFLPVVSEFLNSSIFVLSSRFEAFGNVLVEAKICGVPSIAFNVPSGPKEIIVDGEDGFLVDYLSINEMANKIIYLIDNPSVRVRMGRRAKINSESFSVDAILALYNKTIMQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0C0</accession>
    <name>C6X0C0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00338"/>
    <dbReference type="EnsemblBacteria" id="ACU06805">
        <property type="protein sequence ID" value="ACU06805"/>
        <property type="gene ID" value="FIC_00338"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00338"/>
    <dbReference type="HOGENOM" id="CLU_766737_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="252"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="361" mass="42100" checksum="DE744580AC3FEA25" modified="2009-09-22" version="1">MVSILSQTKVKRPSKFRHYLMNSYLNNLRSIIFIKINNLKPSVLIISDFPQWAYHGIQHFIAESLNSEYDFYYDFLIFNSKRRSKNPKTILSNYFLKKKYTKLKNDRHYDIVLYLAFYFDEQMKINFTATKTIKGIYTDGFPPSNSTYEGDVTGFMKRFFSNTDAMVCGSQNIRGFYEPVFSKVYFANGVIDDKLFSRKSARSKDKFVIGWTGNPNREFKGYYSHILPAIEILKKKYEDIEFVSRFSGPLVTLPQFYEQLHLVIIASEADAGPALFGEASLMEVPCVTTKIGWPAEVIQDGLSGFFVEREVRDIVSKVEVLYNNRSLLESMAVRIRVDYQNHFNKDQMIDNWRTLFNNVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0E6</accession>
    <name>C6X0E6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06832">
        <property type="protein sequence ID" value="ACU06832"/>
        <property type="gene ID" value="FIC_00365"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00365"/>
    <dbReference type="HOGENOM" id="CLU_3183952_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="46" mass="5306" checksum="6CD9996C88D937C1" modified="2009-09-22" version="1">MVGGAIVNQQQFEIAASLIQYGINAFFQMFFRVVNGYDNRKIHLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0I1</accession>
    <name>C6X0I1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00400"/>
    <dbReference type="EnsemblBacteria" id="ACU06867">
        <property type="protein sequence ID" value="ACU06867"/>
        <property type="gene ID" value="FIC_00400"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00400"/>
    <dbReference type="eggNOG" id="ENOG5033J36">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064693_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="365" mass="43316" checksum="EF05D5E7329F9865" modified="2009-09-22" version="1">MNLGFNFLFIFESNLRKLFANALLIEVYSGFANVFGMLFLLSIMNKRRNIKMKKILFGLSVFFTTLMSAQIYQDYYPTSDNSAGYSDVYDDEFYFPDDYYYEYPADYYSNDLYRSYYDDYRRSIYDVNWNRFFSAYQLAPWQIQQIMMLNDQFRSYSAWNSYYRYNPDRWYYDRFYSLERILGPRIFVIFQNNYYNGYNPVVYYQNYRRQHYVPHVYVVPRYRNININRYRVDRVKYHQTNPRQNIGFRDNPRTANSNGNIAPRADGFREGAQKSGSTQGFRNEGDGVVRSAPRVQNGGLRSPEVKPQAESPKSNSGLRNDRSEIRNSAPQRRIENNSPSPRNQTPGLRTPAASARTSGQRLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0J4</accession>
    <name>C6X0J4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="15" type="ordered locus">FIC_00413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782027.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00413"/>
    <dbReference type="EnsemblBacteria" id="ACU06880">
        <property type="protein sequence ID" value="ACU06880"/>
        <property type="gene ID" value="FIC_00413"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00413"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_10"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="38"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="278"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="791"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="712"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACU06880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="937" mass="108097" checksum="A0653C5F7EFAC2CC" modified="2009-09-22" version="1">MFYDHQSIEKKWQKFWKENQTFKTEDNTQKPKYYVLDMFPYPSGAGLHVGHPLGYIASDIYARYKRHEGYNVLHPVGYDSFGLPAEQYAIQTGTHPAITTEQNITRYEEQLRKIGFSFDWSREVRTSDSSYYKWTQWIFIELFNSWYNKAEDKAEPITTLIEYFAKNGSAELSAAQNDELNFSAEEWNNACELDQQDILLNYRLAFRAETTVNWCPGLGTVLANDEVKDGKSERGGFPVFQKKMMQWSMRITAYSERLLQGLQNIDWPQPLKDAQEYWIGKSQGAQVTFGLDNGTEQITVFTTRPDTIFGATFMVLAPENPLVETITTPNQKEEVENYIQETSKKTERDRMADVKNVSGAFTGAYAVNPFTHEKMPVYISDYVLMGYGTGAVMAVPAHDERDHRFAKKFALPILNVIKNDEDINETSYDSKNSVCVNSGFLDGLNYTEAKAKIISEIEKLGIGRGTTNYRQRDAIFSRQRYWGEPVPVYYKDGMPYPLPVSALPLELPEVEKYLPTEDGDPPLGNAKNFGWDEKNEKVVATELIDEKSVFALELSTMPGWAGSSWYFLRYMDPHNDEVFAQKELTDYWGQVDLYIGGSEHATGHLLYSRFWNMFLKDRGYVQHDEPFKKLINQGMILGMSAYVFRIEGTNQFISKNLIQDHTTQKIHVDVSLLKGTSDELDIERFKNWRSEYADAEFILEDGKYITEREVEKMSKSKYNVVNPDDICEEYGADCLRLYEMFLGPLEQSKPWNTQGLSGVYGFLKKFYNLYFNGDQFEVSDEEPTKEEYKILHTLIRKVVSDIANFSFNTSVSSFMIAVNEYQKLKTNKRQILEAMAVIVSPYAPHLCEELWSRLGHNSTVELEKFPEFDEKYLVEDEFEYPVSFNGKMRFKLSLPADYTVSEIEESVMKDQRVINQLAGNSPKKIIIVQKKIINIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P5</accession>
    <name>C6X0P5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ordered locus">FIC_00469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782078.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00469"/>
    <dbReference type="EnsemblBacteria" id="ACU06931">
        <property type="protein sequence ID" value="ACU06931"/>
        <property type="gene ID" value="FIC_00469"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00469"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_1_10"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU06931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="89" mass="10091" checksum="549299E125E654B2" modified="2009-09-22" version="1">MYLTTDKKKEIFAKHGKSDADTGSAEGQVALFTYRINHLSSHLKANHKDYATERSLVALVGKRKALLDYLKKKDIARYRAIIAELGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>C6X107</accession>
    <name>C6X107_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01676"/>
    <dbReference type="EnsemblBacteria" id="ACU08120">
        <property type="protein sequence ID" value="ACU08120"/>
        <property type="gene ID" value="FIC_01676"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01676"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_2_0_10"/>
    <dbReference type="OMA" id="WIENTEW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="123" mass="13811" checksum="5568A3F53210236E" modified="2009-09-22" version="1">MRPASNCLIINFKAMSLRNKVTLVGRTGKDVEIVNFENGKLAKVSLATSDYYTNGLGEKVEETQWHNLVAGGKLADIMQKYVEKGKEIAVEGKVMYRTWDDKTGAKHYMTEIRVEELVLLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X130</accession>
    <name>C6X130_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphohydrolase MazG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01700"/>
    <dbReference type="EnsemblBacteria" id="ACU08143">
        <property type="protein sequence ID" value="ACU08143"/>
        <property type="gene ID" value="FIC_01700"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01700"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_10"/>
    <dbReference type="OMA" id="HPHIYGD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="272" mass="31626" checksum="F3D81CCB99050EA6" modified="2009-09-22" version="1">MCSIQYKHSTMNSRQEKLEAFGRLLDIMDDLREKCPWDKKQDFQSLRHLTLEEVYELSDSILEEDLPEIKKELGDVLLHLVFYAKLGSEKESFDIADVINSLNEKLIYRHPHIYGDVEVKDEDEVKENWEKLKLKEGNKSILAGVPKGLPSLVKAYRIQDKVKGIGFEFADADDAWKKVDEELAEFHAETDLHEKEKELGDLFFSLINYARISGLNPDSALERTNIKFIARFQHMEQLAVAQNIKIEDLTLAEMDKLWEKAKEAEVQNEQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C6X138</accession>
    <name>C6X138_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FOG: PAS/PAC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01708"/>
    <dbReference type="EnsemblBacteria" id="ACU08151">
        <property type="protein sequence ID" value="ACU08151"/>
        <property type="gene ID" value="FIC_01708"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01708"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472284_0_0_10"/>
    <dbReference type="OMA" id="LTHEIRY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="349"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="572" mass="65553" checksum="F566A19E8CD502D5" modified="2009-09-22" version="1">MTINSMTENRNNRPLVHYSLIAATLLIQVVIAVFIYNEYFNQKKLESIESQLRDSRTLEKAAREARTDLLQAQNHLQLYMDTQGRENLEAYFASLRKLSRNLDSISGSPDLNPELAKLIQRKKSELTSLPDLDGLIRSVYQESQKPKSERKPIVIKEINIPAPATSYRTDIERRADTLAKKPLLSRLKDAINNETEVQREVVLVTTNRTDSLDTSKIRTDMDSIVRNLQSHYQDEIRKYEAGIVSARQQSDNLYRTYDQLIRISNNWMEVYTYAIGDYNAKLQEQLDDQRSVNSQVRRYTLVGLIVLMFLVLLLIIYFTRQSFEYQRELRAANAEIRNNLKFKNRVLGMLSHEVLAPLKIINLFIDRISRKNGDSVIEGHLQSMKFTNSSLLIQAGQILEYAKNQERKPVLHPEKFNLFNETERILQVFGPFIESRNNVFEVENTIPADTAVFADKILIYQLFTNILGNANKFTENGRIAVSTRISSEEKLRYRMDVTVADTGSGISSADLKRIFEPYYQGQSSAGPENIGAGLGLNLCRETVELLGGKIWAESQSGRGTTINFYIHLDKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>C6X179</accession>
    <name>C6X179_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="9" type="ordered locus">FIC_01749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01749"/>
    <dbReference type="EnsemblBacteria" id="ACU08192">
        <property type="protein sequence ID" value="ACU08192"/>
        <property type="gene ID" value="FIC_01749"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01749"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_10"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="452" mass="51332" checksum="5C845B13D89FC08D" modified="2009-09-22" version="1">MGLFNFTPKHLYLRLQKNCKKMNPFIEELKWRGLYADMMPGTDEQLNKETTTAYIGFDPTADSLHIGSLIQIKILAHFQQHGHKPIALVGGATGMIGDPSGKSTERNALDEETLNHYVSCLKSQLSKFLKFDGTESNSAELVNNYDWMKEFSFLEFIRDIGKNITVNYMMAKESVKKRITGEGGAEGMSFTEFTYQLLQGYDFLHLYREKNVKLQMGGSDQWGNITTGTELIRRKAQGEAFALTVPLITKSDGSKFGKSESGENYWLDPKKTSAYKFYQFWVNATDEDAERFIKFYTFLSKEEIETLIAEHKTAPHERKLQKKLAEEVTVWVHNQAEYEKAVKASEILFGRSTAEDLVNLDEATFLEVFEGVPQKELTKDEVLAGNIIDLISEKTGFLKSKGEARRELQSNAISVNKEKVTDSFEVAAKDLIDGKFLLIQKGKKNYFIVKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1B1</accession>
    <name>C6X1B1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806509.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01781"/>
    <dbReference type="EnsemblBacteria" id="ACU08224">
        <property type="protein sequence ID" value="ACU08224"/>
        <property type="gene ID" value="FIC_01781"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01781"/>
    <dbReference type="eggNOG" id="ENOG502ZZB9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108362_1_0_10"/>
    <dbReference type="OrthoDB" id="1719611at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="193" mass="22047" checksum="26E059A47DC644B6" modified="2009-09-22" version="1">MVYKIRIILDARDDIFRDVEIKDKQNLWNLHLGIKSAFTLMGEDLSVFSILDEEGTVVKTVPLEDMSDDGEGEIMSDVYISEAFEKVGDKLHFQYGFMDLWEFFLELVEITDEKPAVNYPITVFRFGNMPLKAPSKTGAKKPKNSAPLMDDEFGSFEDEFAAGSFADEDEDNFDDEEDDYNDDPFADDDSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1C1</accession>
    <name>C6X1C1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806519.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01791"/>
    <dbReference type="EnsemblBacteria" id="ACU08234">
        <property type="protein sequence ID" value="ACU08234"/>
        <property type="gene ID" value="FIC_01791"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01791"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_10"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="380" mass="41573" checksum="0B44F7DE18020A11" modified="2009-09-22" version="1">MNFNTKVIHGGQHHESATGSVNVPVFLTSTFAQKSPGIHSGYEYSRAANPTRQALEDSLASIENGARGLAFGSGLAAIDCVLKLLNPGDEIIAVDDLYGGTYRMFTRLFEKYQLKFTFVGFDDVAKISGLITDKTKLIWLETPTNPLMKLVDIKAVTDLVKGKDILVAVDNTFATPYIQQPLDLGADIVMHSATKYLGGHSDVIAGALIAKTAELGEKLHFIQFASGGILGPHDSYLVLRGIKTLALRMQRHSYNGLEVAKYLENHPAVDRVIYPGLESHPQYELAQRQMKEPGGMVSFTFKSGKKEDAVKFLERVKVFTLAESLGGVESLANHPTLMTHASIPEDKRLELGITDDLVRLSVGIEDKDDLLADLERAFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1H7</accession>
    <name>C6X1H7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806575.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01847"/>
    <dbReference type="EnsemblBacteria" id="ACU08290">
        <property type="protein sequence ID" value="ACU08290"/>
        <property type="gene ID" value="FIC_01847"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01847"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134999_0_0_10"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="149" mass="17201" checksum="24E0B33ECA1A3B5A" modified="2009-09-22" version="1">MRSNTVLKSDVRTFVLGVISEKIQKLEKFLEFTLDASRDIKKTPKYDSIREEIQEEIYRMQRQLGALNDMQRNMTKVLNSPTERVQIGSVVFTNKARFYISVSLGEFFFEGDRFYAISEESPMAKTMFGKQAGDSFVLNNISQTIESVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J3</accession>
    <name>C6X1J3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="2">PNP synthase</shortName>
            <ecNumber evidence="2">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdxJ</name>
        <name evidence="3" type="ordered locus">FIC_01863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01863"/>
    <dbReference type="EnsemblBacteria" id="ACU08306">
        <property type="protein sequence ID" value="ACU08306"/>
        <property type="gene ID" value="FIC_01863"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01863"/>
    <dbReference type="eggNOG" id="COG0854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074563_1_0_10"/>
    <dbReference type="OMA" id="SNAGWDT"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="3-amino-2-oxopropyl phosphate binding" evidence="2">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="258" mass="29252" checksum="048F1155DCC035FE" modified="2009-09-22" version="1">MLHRNSTSKWFRFQKFNNKMVKLSVNINKIATLRNARGGELPSVTEAAVKLQEFGAYGITIHPRPDERHITRKDVYDLKPHVHTEFNIEGNPHQPFIDLVLDVKPEQVTLVPDAEDAITSNAGWDCEVHMDFLKNVIAQFKNAGIRTSIFLDPNPGMVKFAKETGTDRIELYTEAYARNYSEDKEAAIRSYVETALEAERHGLGVNAGHDLSLENLKYFADNIPNLLEVSIGHALISEALYMGLENTVQSYLKRLAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J4</accession>
    <name>C6X1J4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806592.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01864"/>
    <dbReference type="EnsemblBacteria" id="ACU08307">
        <property type="protein sequence ID" value="ACU08307"/>
        <property type="gene ID" value="FIC_01864"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01864"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045354_1_0_10"/>
    <dbReference type="OMA" id="PTWRLMS"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030192">
        <property type="entry name" value="YbdG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30414">
        <property type="entry name" value="PTHR30414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="419" mass="47344" checksum="1F9FBE4DC5AC9B75" modified="2009-09-22" version="1">MNEFNNTKDFLQAMSDSLHYFVKDTVPDSWVLLIQIVLKFSFLVGIIVLAYLALSLLMNGIFKAYFNTDKHPVLKSVYLSKITNSLANLIALLIGSFALFSIFYRHPKSFTFLERMVALAIVIVVAGMLYRGLSAFRHYFVIKQDFYKIIALNAVSQTVQIFGIFVASVVAICVIFGISGSAIVGSLGAITAVLVLVFRDTILGFVTGIHVATSKNLKVGDWIGIPKYNLEGNIMDINLLTTKIQNFDKTISTVPTYDFLTTEIKNIQVMTESNTRRIKRSIIFNIKSFKFLDAETADRLAGINLIADYLEQKKAEINEQRGTMRNAERLINGRQLTNIGVFREYVQNYLKNSPHIDQEGTVIVRQLENTPHGMPLEIYCFTNDSEWATYEDILADIFDHLLVASQEFDLEVVQIPKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1J9</accession>
    <name>C6X1J9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhamnogalacturonan acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806597.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01869"/>
    <dbReference type="EnsemblBacteria" id="ACU08312">
        <property type="protein sequence ID" value="ACU08312"/>
        <property type="gene ID" value="FIC_01869"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01869"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_2_0_10"/>
    <dbReference type="OMA" id="RSDCPGT"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972213" evidence="1">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="31"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="249" mass="28531" checksum="DD081C6901C86446" modified="2009-09-22" version="1">MKIYKLLLLAAVLLVACKANNNYKKVTIHTIGDSTMANKPNPEKNPERGWVQVLDQYFNENVEIKNYAVNGRSTKSFRDRGHWKPVLEALKPGDYVFIQFGHNDGKDTDPERYTNPQTSYRYNLIQYIEEARSKGAVPILFSSIARRKFNKEGVLLDAHGNYTLVARLVASEMKVPFFDMQYLTENLEMAYGVEESKKLHLHFAKGENEFFPDGIDDNTHLSVLGANEISKIFAAELKRQNHPLAKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M4</accession>
    <name>C6X1M4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartokinase</fullName>
            <ecNumber evidence="3">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806622.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01895"/>
    <dbReference type="EnsemblBacteria" id="ACU08337">
        <property type="protein sequence ID" value="ACU08337"/>
        <property type="gene ID" value="FIC_01895"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01895"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_0_10"/>
    <dbReference type="OMA" id="ESVTIWK"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU08337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="412" mass="46650" checksum="7FD2139BE716F9A6" modified="2009-09-22" version="1">MKVYKFGGASVKDADGIKNVARVLGSQGFERCVLVVSAMGKTTNFLEKVVQQYFAKLDFQHEINEIKQNHLSIAKDLFETDHAVFGEISLLFDDVSAFLQRNKSPNYSFVYDQVVSSGEMVSSKILSAFLNTQGFENSFLDAREYIKTDSTYREGVIDWEQTYRNISDLDIEKSYVTQGFIGSESDNFTVTLGREGSDYSAAVFAYCLNAEMLTIWKDVPGVMTGDPRKFEDVSLLTNISYEEAIEMAYYGASVIHPKTLQPLQQKNIPFYVKSFLEPEKSGTKVGAADNNCYEETYILKENQQLMRIATRDFSFIAEDHMSQIFSLLAKFKIKISLMQNSAISLALCLEDKYGRIDELNRELSQMFTTEIIRGVSLFTVRNADLQNLDSFYAGKNILLEQISKKTVQVVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R9</accession>
    <name>C6X1R9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01940"/>
    <dbReference type="EnsemblBacteria" id="ACU08382">
        <property type="protein sequence ID" value="ACU08382"/>
        <property type="gene ID" value="FIC_01940"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01940"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787245_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="358" mass="41037" checksum="4267468ECD49807F" modified="2009-09-22" version="1">MMKILIPLVGTFGRSGGFRVLSHLANYWIKQGHEVCFLSYIVAEDPYFPTDAEILYYDNKGDVSSAKNLYQRRPMFGMFTLRFSLRKAMDKVEADIILANHCFSALPVMQSSNNARKFYYVQAYEPEYYYNKTVKDLIYKRISKNSYKLGLETIVNAEMYRNYKEIKTDKVVFPGLDLGVFKPDVEERHFGEKVVLGTIGRVEAYKGTAYIIKAFKQLRAEWGDKIELHVAFGDHALADVEGIKVIYPENDAELAKYYRSITMYICAGTVQLEAIHYPVIESMGCKIPIITTGYYPASDENAWIIPPKDSAAIRNTVVKVLNSEVIAKVKCESAYLNVKEFSWDAVGDKMLNYFRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U8</accession>
    <name>C6X1U8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proprotein convertase, P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806696.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01969"/>
    <dbReference type="EnsemblBacteria" id="ACU08411">
        <property type="protein sequence ID" value="ACU08411"/>
        <property type="gene ID" value="FIC_01969"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01969"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006954_0_0_10"/>
    <dbReference type="OMA" id="KYRTMRL"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973353" evidence="1">
        <location>
            <begin position="20"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="657"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="978" mass="104175" checksum="43B5688497590E5E" modified="2009-09-22" version="1">MKRIFTSLLCGLMSTAAFAQWSPTSMQGERIRTTSNVKSYYSLDLDQMRSTLANAQETGRNAVPVEIKLPTLNGKIERFAVYSAPVVVKSLADRYQLGSYIGQGIDDPNAFVRFSVAPNDFQSMVVRNGVYEFVEPQNKEKSVYGVLPKTNKSEADKAFVCSTSEAPLSKSQLDKLYMSGKSFTNNPTDFSKASDKKYRTMRLVMSTNAEYTAYHGGVAGALTAINATITRCNGIFEMDFGLHLILQDFPALIYTDPATDPYSTTLSTWNLSAQKAITAVAGEANYDIGHMFGASGGGGNAGCIGCVCISPPLNTAGVPTGNGKGSGITSPADGIPQGDNFDIDYVAHEIGHQLGANHTFSFQLEGTGVNVEPGSGSTIMGYAGITGATDVQPHSDAYFHHVSINQVQTNLTSKTCDIETAVANNPPVITAMADVTIPKSTAFVLTAQATDPENDPLTYTWEEVDNATTSTTIASLGTLTNGPTFRSWTPTTNPTRYFPKLSTVLAGSLKNNTDWEAVSTVARVQNFRVTVRDNNADVAQKQTQNALQKVTISANGPFKITSTKVYNNAPGPLTWDVVGTNAAPFNVANVKIDYTSDNGATWNVLSASTPNDGTEDFSFATFATNTALKVRISAIGNVFYAVAPVTVSAIVACDGTAPAGLTVSSITTAGASITWDPVVGATYIVRYKKATDATWIEVPVTANSLALTDLEEGTAYNVQVAAVCTGTTGSYTTVTDFSTLMLAYCTLTSSNPNDEYISNVAIAPEGAAGMVSASGPSTYTNYSSDATRLVNLARGTTNNTITVTKFWTGTVYNEAVTAWIDFDRSGTFDNDEIVMSTSADKLNPVSDIFSVPADAYVGDKTVGMRVALRFSTPQTTPCGTYTYGEVEDYAVKISATLGVNDNVKSNSVQVYPNPAIDLLNITKVSDKATYTIFNMAGQAVSKGKVTDNKVQVSQLAKGVYMISVNNDGQVSQVKFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1U9</accession>
    <name>C6X1U9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806697.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01970"/>
    <dbReference type="EnsemblBacteria" id="ACU08412">
        <property type="protein sequence ID" value="ACU08412"/>
        <property type="gene ID" value="FIC_01970"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01970"/>
    <dbReference type="eggNOG" id="ENOG502ZC9Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233448_0_0_10"/>
    <dbReference type="OMA" id="KLGAFYM"/>
    <dbReference type="OrthoDB" id="1459079at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046111">
        <property type="entry name" value="DUF6048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19515">
        <property type="entry name" value="DUF6048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973485" evidence="1">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="219" mass="24231" checksum="1B6007199D640D37" modified="2009-09-22" version="1">MNPRLTFSFFFSCLAAVLCAQQPPDTLQAKWKYQPNFMVGIDLLNAGTSVFSDRKLFQGFVSSRISRNIHAVADAGFEKNIYRKNGYDATANGPFIKLGAFYMLAQDKENHLNGFYAGAKAAASFYSQEYFAVPVRGFGGSDTSAAFPASSQSSAWLEGTVGGRVQLFDSPFYIDVNMQPKYLLYSSTQEEIQPMIVPGFGKSSSKFNMGFSWNIAYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y4</accession>
    <name>C6X1Y4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ordered locus">FIC_02005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806731.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02005"/>
    <dbReference type="EnsemblBacteria" id="ACU08447">
        <property type="protein sequence ID" value="ACU08447"/>
        <property type="gene ID" value="FIC_02005"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02005"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_10"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="115" mass="12479" checksum="1319DF76C9A1498C" modified="2009-09-22" version="1">MALSKVEKRNRIKRRVRGKISGSSELPRLSVYKSNKEIYAQLIDDKDGKTLASASSRSLNATGTKVEISAEVGKAIAEKAKAAGIEKIVFDRNGFVYHGRVKALADGAREGGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X200</accession>
    <name>C6X200_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ordered locus">FIC_02021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806747.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02021"/>
    <dbReference type="EnsemblBacteria" id="ACU08463">
        <property type="protein sequence ID" value="ACU08463"/>
        <property type="gene ID" value="FIC_02021"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02021"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_10"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU08463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="208" mass="22464" checksum="10B8FD20250AAAAB" modified="2009-09-22" version="1">MSGIIGKKIGMTSLFDENGKNMPCTVIQAGPCSVLQVRTIEKDGYKAAQLGFDDKSEKNVGKALIGHFKKAGSAPKAKLVEFYHEFVDKLSVGDEVKVDLFSQGEFVDVTGTSKGKGFQGVVKRHNFGGVMQATHGQHNRLRAPGSIGAGSDPSRVFKGMRMAGRMGGKQVTVQNLQVLRVDEEQNLLVVKGAVPGAKNSYVIIRKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X222</accession>
    <name>C6X222_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.24" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806769.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02043"/>
    <dbReference type="EnsemblBacteria" id="ACU08485">
        <property type="protein sequence ID" value="ACU08485"/>
        <property type="gene ID" value="FIC_02043"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02043"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055419_0_0_10"/>
    <dbReference type="OMA" id="SNKGHDG"/>
    <dbReference type="OrthoDB" id="687997at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023917">
        <property type="entry name" value="Bifunctiontional_GlmU_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13562">
        <property type="entry name" value="NTP_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03991">
        <property type="entry name" value="alt_bact_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="386" mass="43404" checksum="33E09F098C9C39BB" modified="2009-09-22" version="1">MQLVFSDAQFWEDFLPLTFTRPIAEMRCGILTFSERWQRLLDISEISFITEDFLQHKFAKPAKVESLFLVPNFLPTETVLKQIKELKLGEALVYNNELLAVRINMENFSLNQIEKMTDIEGELRFYKQPTDLFSFNQEAIDFDFELITKGRVSAELSATNGFLGNREDLFIEEGASVEFSTLNTKTGKIYIGKDAEVMEGCNLRGPIALCEESKFNLGAKIYGATTVGPHCKVGGEVNNIVIFGYSNKGHDGFVGNSVIGEWCNLGADTNSSNLKNNYAEVKLWNYRTKRFANTGLQFAGLVMGDHSKTAINTQFNTGTVVGVAANIFKSGFPPNLIDSFSWGGMKGDEKFKLEKAYEVAELAMARRKVAFTEEDRNILKYIYSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X258</accession>
    <name>C6X258_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemagglutinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02084"/>
    <dbReference type="CAZy" id="CBM50">
        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="CAZy" id="GH73">
        <property type="family name" value="Glycoside Hydrolase Family 73"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08521">
        <property type="protein sequence ID" value="ACU08521"/>
        <property type="gene ID" value="FIC_02084"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02084"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013771_1_1_10"/>
    <dbReference type="OMA" id="QIGWSAS"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973362" evidence="1">
        <location>
            <begin position="25"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="304"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="355" mass="40863" checksum="916305506FA859FB" modified="2009-09-22" version="1">MTKQQFMKRIFFAFALIIVSKTQAQTWKNDEQYIQKFAAYAVEEMEKYKIPASIKLAQGLLETGGGQSRLAQIGKNHFGIKCKEDWTGKSMKHTDDAPNECFRVYDDPKESYEDHSKFLTNRKYYVNLFKLDIKDYKAWAHGLKKAGYATNPRYAYILIDKIEKNRLYEFDNTNSKEVLYTVLKMYPALRDDRIFMAQLDQSKASSKPVTVKVPYEQTSYARQQQTVEKIKTRAEILNTVLVKNHPNGGKKFVIIPEDTDLELISKKFGISESKLMKWNELDGTALKRNDVIFLEGKASDGNVATYKAKVGETMHDVSQKFGIKLSKLYSKNRMAYGQQPKSGQLIYLQGKKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2B0</accession>
    <name>C6X2B0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806857.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02137"/>
    <dbReference type="EnsemblBacteria" id="ACU08573">
        <property type="protein sequence ID" value="ACU08573"/>
        <property type="gene ID" value="FIC_02137"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02137"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_0_10"/>
    <dbReference type="OMA" id="YTGIMTD"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="247"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="335" mass="37758" checksum="A1EF6C5EEA935B07" modified="2009-09-22" version="1">MFTPSEISSIRKLLTPDSKIVIITHYNPDGDAIGSSLGLKHFLKQKGLEADVIAPNDFPKFLKWMPEAKKIIIADYKRKVAGEAIYNADVIFVLDFNASHRSGNLVGPWLDKARAVKILIDHHQQPDDFDFVYSDVTIPATSQMVYHFIQALEEEDKVNTDIAECLYTGIMTDTGGFRFRSTSATTHRIIANLIEKGADPAMITSSTWDTNTVSRLHLLALILGRIEVVKDGKVAILFLKRDELKEFGFQKGDTEGFVNYGLSIMGTQVSAFFMEDLYEDFIKISFRSKDDVDVNQFSRQHFHGGGHINAAGGKYFKNIEETIEDFKEKIEAEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E3</accession>
    <name>C6X2E3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02170"/>
    <dbReference type="EnsemblBacteria" id="ACU08606">
        <property type="protein sequence ID" value="ACU08606"/>
        <property type="gene ID" value="FIC_02170"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02170"/>
    <dbReference type="eggNOG" id="ENOG5032Y58">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210795_2_0_10"/>
    <dbReference type="OMA" id="AYIFDEQ"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025379">
        <property type="entry name" value="DUF4295"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14128">
        <property type="entry name" value="DUF4295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="51" mass="5507" checksum="7CD0AA96F1A36E19" modified="2009-09-22" version="1">MAKKVVASLQGGAGSKKMTKVVKMVKSPKSGAYVFDEKVMNADEVEAYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E9</accession>
    <name>C6X2E9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidyl-dipeptidase I</fullName>
            <ecNumber evidence="9">3.4.15.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.15.5" evidence="9"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02176"/>
    <dbReference type="MEROPS" id="M03.005"/>
    <dbReference type="EnsemblBacteria" id="ACU08612">
        <property type="protein sequence ID" value="ACU08612"/>
        <property type="gene ID" value="FIC_02176"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02176"/>
    <dbReference type="eggNOG" id="COG0339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_4_0_10"/>
    <dbReference type="OMA" id="KRSGAWC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="PTHR43660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="8">
        <location>
            <begin position="219"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="671" mass="75899" checksum="7D5B88FF05F94633" modified="2009-09-22" version="1">MKKSTLQYQAPEFDKIRDEHFKPAFDYGMKVQLAELDQIANNSAAPTFENTILALENSGEILKRAQLVFYNLTGSNTNPALQKLEEEYAPVFSGLSDKILLNEKLYARINAINTAGLGAEEKRVVELYKTNFEIAGANLSPENKEKVKKINEELATLSTQFTSKLLDARKNGAVVISDVKELDGLSQDEIAAAAADAKAAGHEGKYLLTLLNTTQQPLLQNLKNRATREKLFKASWYRAEKGNADDTRSILERQARLRLQKAQLSGKKSFAEWKLQDQMAKTPEKALDLLAQLATPAVATAKRESNEIQALIDKQKGGFTVEPWDWNYYSEQVRKAKYDLDENEIKPYFEVSTVLEKGVFFAAEKFYGITFKERKDLPVYHPDVVAYEVFDNDGKSMALYYLDFYTRSNKNGGAWMSNFVEQSHLLGQKPVIVNVFNYQKPAEGKPSLISYDDVSTMFHEFGHTLHGLFADQKYVLISGTNTPRDFVEFPSQINEFFALEPSVLKNYALHYETKKPMPQALVEKIKKAASFNQGYSTTELVSAATIDMSWHSVTDESQFKPTLEFEKDALAKFGFNLKQVPPRYHSPYFAHIWGGGYSAGYYAYMWSDLLNADAWDWISTNGGMTRANGDRFRKHILSVGNSVDLNQAYRDFTGRTPDIKPLLINKGFISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H7</accession>
    <name>C6X2H7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02205"/>
    <dbReference type="EnsemblBacteria" id="ACU08640">
        <property type="protein sequence ID" value="ACU08640"/>
        <property type="gene ID" value="FIC_02205"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02205"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_10"/>
    <dbReference type="OMA" id="YRFSIDM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="352" mass="38643" checksum="222B2EAF861595B8" modified="2009-09-22" version="1">MSNTQVKAFGTEAKDKDLELMQIERREVRPTDIEIEILYCGVCHSDLHTARNDWGGTKYPSVPGHEIVGRITNVGAEVTKFKVGDLAGVGCLVDSCRECESCKKDLEQYCLNGSVGTYNGKDQFLGGHTFGGYSEKVVVDEAFGLHIPENLDLKAVAPLLCAGVTTWSPLKHWDVKEGSKVAVVGLGGLGHMAIKLAKGLGAEVTLFSRSPDKIQDALDLGADHVVISTYENEMKAVKGKFDLIIDTVPYDHDINPYITTLNISGTIVLVGYLGKMEDLLFTVPLIVGRKSVAGSVIGGIKETQDMLDFCGEHNILPEIEMIKMQDINQAYERMLKSDVRYRFVIDMQSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P0</accession>
    <name>C6X2P0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806987.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02270"/>
    <dbReference type="EnsemblBacteria" id="ACU08703">
        <property type="protein sequence ID" value="ACU08703"/>
        <property type="gene ID" value="FIC_02270"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02270"/>
    <dbReference type="eggNOG" id="COG4757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058232_0_0_10"/>
    <dbReference type="OMA" id="PRYFFDD"/>
    <dbReference type="OrthoDB" id="891360at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017208">
        <property type="entry name" value="UCP037442_abhydr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037442">
        <property type="entry name" value="UCP037442_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="279" mass="31148" checksum="62FC78CA23B1891F" modified="2009-09-22" version="1">MKELYVKTSANTEIAVSVFAPEISNQKLLLINSATGVKQHLYFSFAQYFCSLGFTVITYDYGGIGKSGPADLKGFKSSMRTWGSQDFKAVTGFILLNYPGYTKFCLGHSVGALILGPNQDSKIFHKFIFVATQDAYIGHLRFKIAMLGLFGFGLLMPVITKALGYFPAHWFGLGEPLPAGVAFDWRTLIVHPQSTSRLLEKATEDHSKSLSQKAVVIHAEDDDWVTMKGMESLMNNAYPNLKKSYRELKVSASEKGEIGHVNFFRTYNKNLWKVVSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2P4</accession>
    <name>C6X2P4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02274"/>
    <dbReference type="EnsemblBacteria" id="ACU08707">
        <property type="protein sequence ID" value="ACU08707"/>
        <property type="gene ID" value="FIC_02274"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02274"/>
    <dbReference type="eggNOG" id="ENOG5031NHZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122784_1_1_10"/>
    <dbReference type="OMA" id="GCTVPKW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973503" evidence="1">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="18131" checksum="AA4D5D82187DD2F2" modified="2009-09-22" version="1">MLISTHQTSPNKKTIKNMKKIFAGLFLTASFAFATAQTISFDKTTYDYGTVKNGADGHTMFTVKNTGDKPLIISKVQASCGCTTPEWSQDPIMPGKTAQIKVGYNTTIVGPFTKIIEVYSNDPANSRSVINIKGTVEGQAAAAEMAAPAMEMSTKAVPASVKTNARKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2S1</accession>
    <name>C6X2S1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807018.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02301"/>
    <dbReference type="EnsemblBacteria" id="ACU08734">
        <property type="protein sequence ID" value="ACU08734"/>
        <property type="gene ID" value="FIC_02301"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02301"/>
    <dbReference type="eggNOG" id="ENOG503327B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182832_0_0_10"/>
    <dbReference type="OMA" id="YLFLAFW"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="73" mass="8579" checksum="E1A144B65EE26640" modified="2009-09-22" version="1">MFKNLRDKMETQWFGVLTRMGAKLGIPVSKLRVFFIYSAFATAGVFFLFYLALAFMLWVKDIFITRRPSVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2T9</accession>
    <name>C6X2T9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="12" type="ordered locus">FIC_02319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807036.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02319"/>
    <dbReference type="EnsemblBacteria" id="ACU08752">
        <property type="protein sequence ID" value="ACU08752"/>
        <property type="gene ID" value="FIC_02319"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02319"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_0_1_10"/>
    <dbReference type="OMA" id="VIFAMNK"/>
    <dbReference type="OrthoDB" id="347113at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="451"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="460"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="507"/>
            <end position="511"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="561"/>
            <end position="564"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACU08752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="953" mass="103937" checksum="9C29FEB617F2BF27" modified="2009-09-22" version="1">MPKIRLNKALKEFNISISRLVEFLQSKGIEVESNPNAQLEESAYSALKAEFAKDSEQRKASHEVVMIKVPEEKLEIEPSKPEIIRARNTARPETKILGKIDLEPKKQEVPVEKPEEKPEEKPREEVVLHSPASEKQEFKVLDKIDLSQMEGNKPRAAKKEEAKPEKVDPPAAQPASEPAAAAPAPEQSAPAQSTPQAETPAAAEPASDVHETVYQKLGGVKILKQTVDLSQFDKKPSANSAAAKKKRKRIEKPGTPGATQQGQAGAQGNRPPAQGGNRPPGQGQNRPGQGGNRPGYQGGGANTGKGGSRRGAPTMPVELTDEQVKNQIKETLEKLTSKGGKNKGAKYRKEKRVYRREQDELQHEIDAADRTLKITEFITVGELASLMNVSPTEVISACFSLGVMVTMNQRLEADTLLLVADEFGYKIEFSDADLEESALEENTDTAEDLLPRAPIVTVMGHVDHGKTSLLDYIRKTNVIAGESGGITQHIGAYNVQLENGQRITFLDTPGHEAFTAMRARGAQVTDIAIIVIAADDDVMPQTKEAISHAQAAGVPMIIAYNKVDKPTANPDNIRQQLSSMNILVEEWGGNVQTQEVSAKFGNNMDALLEKVLLQAEMLELKANPNKNAQGVVIEASLDKGRGYISTILVESGTLKVGDYVLAGKNHGKVKAMLDERGKPMETAGPSIPVTILGLDGAPTAGDRFRVFADEREAKSIATKREQLQREQSIRTKKHLTLDELGRRIALGDFKELNIILKGDVDGSVEALSDQLQSLSTEEISVNIIHQGVGQITESDVLLAAASDAIMIGFNVRAGVNAKELADKEEIEIRTYSVIYAAIDEIKEAMEGMLSPEIKEQVIGNVEIRETFKITKVGTIAGCMVLTGKVTRNSKIRLLRDGIVKFDGELESLKRFKDDVKEVTKGYECGLNIKGYNDIEVGDILEVYEEVAVKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V0</accession>
    <name>C6X2V0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807047.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02330"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08763">
        <property type="protein sequence ID" value="ACU08763"/>
        <property type="gene ID" value="FIC_02330"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02330"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044324_0_0_10"/>
    <dbReference type="OMA" id="WTGITAF"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="32"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="382" mass="43119" checksum="54B2372DB6607306" modified="2009-09-22" version="1">MTAGKKIKIAYLCTVAPKDRKVWSGTFFRMYESFQNRGFEIEWIEVGKYTDFENSLFSRVENLYKKLFQRGFNKNHFLLKAFFASRKLTAKLKNSSADIVFAPTYIAELAFVKTNKPIIYLSDATFHQLLNYYGAMSGFGFASKKLTVLVEKLAFKKAEHLVFSSEWAADHAVNFYRIPLQKVDVIKFGSNSAAPDKIIQKDYSGEIVFLFLGIDWNRKGGQIALDAVKILRERNYSVKFKVVGCVPPVTDPVMEVIPFLNKNNPDEAQHILDILNNSEFVFMPTRADCTPISFCEAASYGLPVISTDTGGVSAVVENGETGILLPPSATAKDYADQIEILLKAPEKIKAMANKARLKYDNELNWNVWGDKMNTLIMNLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2V3</accession>
    <name>C6X2V3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LPS biosynthesis related glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807050.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02333"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08766">
        <property type="protein sequence ID" value="ACU08766"/>
        <property type="gene ID" value="FIC_02333"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02333"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_1_10"/>
    <dbReference type="OMA" id="QDIPWTT"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="331" mass="38822" checksum="ABA9E63A3A22D3FB" modified="2009-09-22" version="1">MNPLVTISVPLFKCENFLADCLESVRLQTYQNVEVILINDQTPDNSVAIAEHFISKNQLAHWKIHHLEKNSGLSVVRNKGIDTARGKYIFFLDSDDQILPDAITDLVKMCEDHGLQMAIGDTETVNLETGAITDAFSVNTSEKMIRGNRNIFRGYVNANFPTTSWNKLVETEFLRKNKLYFTKDLYAQDELHSFQLFLKLESVGCLHKKTYRYFLHKYSVIHNRDKKHFDSWATIATYFDAALKPENPEEVNILIKTYLINYKTMTLIMNWKAKKDEKLWIYSYNLYRKVPNLKLSDYFGTKYSIKTRKKALKLELPAWLAMKLFKYQYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2X1</accession>
    <name>C6X2X1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08784">
        <property type="protein sequence ID" value="ACU08784"/>
        <property type="gene ID" value="FIC_02351"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02351"/>
    <dbReference type="HOGENOM" id="CLU_3403663_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="30" mass="3455" checksum="4214BD3C8332D894" modified="2009-09-22" version="1">MIGTKAVIKKRGIILKFFFEFLKIITVAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2Y3</accession>
    <name>C6X2Y3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OmpA-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_02363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807080.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02363"/>
    <dbReference type="EnsemblBacteria" id="ACU08796">
        <property type="protein sequence ID" value="ACU08796"/>
        <property type="gene ID" value="FIC_02363"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02363"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_1_0_10"/>
    <dbReference type="OMA" id="GHEPFSI"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973390" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1108" mass="120739" checksum="77F38B4DA95A6953" modified="2009-09-22" version="1">MNLKPFKKTVLIAAIAFAGYGNVQAQVTTSNMSGIVTTRDGKTSGARITATHLPSGTVYSASANASGAFNLPNMRVGGPYRVEVTTGTEQPIVYEDVYLELGQPFTVNPVFGEKTENIAEVVLTAARGTNVNKTGAATNVGLKQIQDLPQASRSITEFTRLTPQASGNSFAGRDARYNNLQIDGANFNNGFGLSSNPLPGGNSQPISLDAIQEISVNIAPFDVTQSGFTGAGINAVTKSGTNTFHGSLYGYYNGKELNGWKINGNDIQKVSGGQMTNGFTVGGPIIQNKLFFFVSAERETATGANASGANLWRASQDGISDPANNITRVRESDLIAVKNHLINRWGYDPGRYQGYADEAVQQGDKFLARLDWNINDQHKFAIRYNILNGNSMQVANASSGPSPRSTWGRVSDRAMTFENGNFAVENKVQSLTAELNSTFNSSLSNKLLFTYSKIQDLRSTPSDTLFPFVDIWDGSATGGNYISFGTELFSYLNDVINDNFSITNNLTYNVGKHTLTGGLAYEVQKFGNSYTRMGTGYYRYASVADFLSTGTANEVAPIMFGITYPYEGQDTYSRVNFGLGSAYVQDRVALTDRFNFTVGLRAELPFYLNDLTANPSIDALVLRGQDGNPINYSSGEWPDSKVMLSPRLGFNYDVMGDRTLTIRGGSGIFSGRIPFVWLTNMPTNAGVLQNTVEPTSYSQVAGWINNVTFQPQDIYYHLNNVPAGAENVFIQNPNAGAPNTFALVDRNFKMPSVWRSSLGIDYRIPNTLLTLTSDILYTKDVNAVFQYGANRKPSDATMTYAPRAYYPNAASYQYNTAIGANNATILTNTESKGYAFSATVGANLRPWNGLSGSVFYTYSEAEEVSSNSGSSASSSWLASPVIDSPNQDFLSISNFAVPHRVVANVTYDIKQTGTTIGAYYSGAHQGRFSYYYSNDVNGDGLSNDLIYIPVNTADMKFTNITTGSGANVTTLFTAQQQREAFDQFIADNGLEKYRGQILPRNEFLLPWLNRVDVRIAQNLFTNMVQKGDKVQLTLDVLNFGNLINSEWGIQDNTVSSYGAAVLSRAGALSPDPSFQMQRDGSTLVKAPYRPASSRFTTWSAMFGMKYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X355</accession>
    <name>C6X355_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_02435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807152.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02435"/>
    <dbReference type="EnsemblBacteria" id="ACU08868">
        <property type="protein sequence ID" value="ACU08868"/>
        <property type="gene ID" value="FIC_02435"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02435"/>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_3_2_10"/>
    <dbReference type="OMA" id="FTNDECS"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="291" mass="33036" checksum="A32A1CF2203B343C" modified="2009-09-22" version="1">MDKNLLQRLFGGAIYGLLVILCTTPVGSGLINGISPGFVQQQHLYYGLITFFLFAGAWECVKMMKFNPKSWEKWVVFPIIVFIFYRFSKRYFGHGFYFDYNLSELLALSLIVIAVVTLFKFTKELYFDNGKLIFTVIYTALPFGFALGLPKFSSVNETFTLEVFFLFVLIWSSDSFAYFAGRLFGKHKMAPKISPKKTWEGYAGGVILTLILSFFVEKYNVDLRGNWMVVGFLVAVFAPIGDLVESQLKRSFGAKDSGNIIPGHGGILDRLDSFIITVPVVYLYLILEKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X360</accession>
    <name>C6X360_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02440"/>
    <dbReference type="EnsemblBacteria" id="ACU08873">
        <property type="protein sequence ID" value="ACU08873"/>
        <property type="gene ID" value="FIC_02440"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02440"/>
    <dbReference type="eggNOG" id="COG2081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025174_0_1_10"/>
    <dbReference type="OMA" id="RCNFTNM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="416" mass="46394" checksum="DEE1EDA1D41816AB" modified="2009-09-22" version="1">MQPGCGFGHPRDMQKKKIIIIGGGAAGFFCAANLDATKYSVTILEQNSDVLQKVKISGGGRCNVSHACFDPKELAGFYPRGYRELLSVFHKFQPGDTMEWFESRNVPLKIENDNRIFPESNSSQTIIDTLVAEVNSKKFEVRTQSVVSRIERIADQYQVVTASETYTADFVIYCTGSSPKSLKIIQSLGHQIVPAVPSLFTFNIKNETLKDLMGTSFPHAEVAIPKLKTEESGPLLITHWGLSGPAILKISAWKARELAEMKYQFDIKVNFLGIETEEAAEIFTQYRRQNPKKTIGASKIFDVTTRFWHRILWISKINLDKNISTLTSKEVQSMLGGLCANEMKVTGKSTYKDEFVTAGGVDLKEINFKNMASKVLPNFYIAGEVLDIDAVTGGFNFQACWSEAWLMAQDLNALPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X368</accession>
    <name>C6X368_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA (Ms[2]io[6]A)-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02448"/>
    <dbReference type="EnsemblBacteria" id="ACU08881">
        <property type="protein sequence ID" value="ACU08881"/>
        <property type="gene ID" value="FIC_02448"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02448"/>
    <dbReference type="eggNOG" id="COG4445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056571_1_0_10"/>
    <dbReference type="OMA" id="VFYRELM"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045301">
        <property type="term" value="F:tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07910">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010386">
        <property type="entry name" value="tRNA-Hydrxlase_MiaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42637">
        <property type="entry name" value="PTHR42637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06175">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020736">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="199" mass="23527" checksum="D337B3350182965F" modified="2009-09-22" version="1">MPKIHFMFKLRLLTDPRWANIAEGNLEEILTDHAWCEQKATTNAITLITMLPEYPEIITELIKIAQEELEHFQMVHEIIKNRGYEFGRERKDDYVGELIKFIRHGGTRDERIIDRMLFAAMIEARSCERFKVLTENIKDEELKAFYKELMISEANHYTAFIGFARQLGNPEAVNTRWEEWLDYEAEIIKSYGKKESIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3A6</accession>
    <name>C6X3A6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminodeoxychorismate lyase</fullName>
            <ecNumber evidence="1">4.1.3.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_02486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.38" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807203.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02486"/>
    <dbReference type="EnsemblBacteria" id="ACU08919">
        <property type="protein sequence ID" value="ACU08919"/>
        <property type="gene ID" value="FIC_02486"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02486"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114524_0_0_10"/>
    <dbReference type="OMA" id="RCRIDYN"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="201" mass="23658" checksum="EA401BAF596D4BF0" modified="2009-09-22" version="1">MSRFIESIKIEDQQMYLLDLHQRRVDETFAHFGKEGSINLAKIYKSLEHDGDGLFKLKISYDLDKNFRTQIIPYAISEIDSFRLVENNSYDYSFKFEDRAPLELMLRQAKTDEIIIVKNNHITDTSFSNILFKKGKDWFTPTTCLLNGVQRQHLLKTKKIKSAEITVQNLDEYSHFQLINAMNDFDDMFIYPLSKITNLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3C4</accession>
    <name>C6X3C4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807221.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02507"/>
    <dbReference type="EnsemblBacteria" id="ACU08937">
        <property type="protein sequence ID" value="ACU08937"/>
        <property type="gene ID" value="FIC_02507"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02507"/>
    <dbReference type="eggNOG" id="ENOG502Z80K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326187_0_0_10"/>
    <dbReference type="OMA" id="TILMADE"/>
    <dbReference type="OrthoDB" id="1230371at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="883" mass="99161" checksum="B3333F47540B8B57" modified="2009-09-22" version="1">MKKKYLRPLSIFVAVVVLITLVLNFGANFWLRNNLSGYIKKNSNYNVKYSSLEVDMFTGRISAAGISVRSKNSGDQNTIGLEGSIDTLSVSRLGIYDVLFNKTISSNNLLLVKPDLKITLAKPVDDKTKKKRNPVLFKNLKISNGNITVLRHTKQKFLEVKDLELNVENIQMTEESMERKLPLVFDTYDIKGKDFYFGPDDVYAVTAQTITTEAGQMSIRNFAVKPLLSYQNFRRFHPNDKNLYDFKATEMNFKDVALDDDKVALSHAHFQNPDLKIMTTSAKAVRKKKDLNVTVNMEDVLFKNAKISILNPNGTPKLSAADVTLNINKFVMDSETSKSPLPFEYANFSVAGKQINFVTETQNINIAALAFNPKAVDIRLLRMKPAGQQTTKTIMDLDVDRVRLNINEFRFVENKLKLDVQNILISSMQGKIQAAKNSQKKKGDYSGIEFPLTVKNVELKNSNVAYDNGKAVLILNNLNAKIQNIEMNAATVKNSVPFKTGNYSLAAQKLVYNTEFYNMSAGLLTFGNRSLQLSDFATTPKVSRAQFIRMIPAERDLYDVKVKQITANGIWDLLSDNQYINASQVTLNGMNANIFRSKIPKDDVTEKLLYSSLLRKIKMPLFVQNLDIKNSVLEYEEDTKRSDGPGKLTFGSFAMNVKNLNSGKMKGKPTQVAISVNCRFMNASPMNVKWNFDLLNRSDSFSISGNVADLPASRVNPFIEPYLKVRATGMISDLIFNFKGNSSGLSGILNLKHKDLKVALLKEDGEKNKLLSAVANIFVRSDSGQYPESVPVDNVPRDKTKSFFNFFWKGIEEGLKKTLIGKNVENTEKAVQNTVENTKAALDQNKKDLKDTKQNVTEKVENAKDKVQKKSSGLKNILKKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3D4</accession>
    <name>C6X3D4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidyl-peptidase</fullName>
            <ecNumber evidence="4">3.4.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase S46 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807231.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02517"/>
    <dbReference type="MEROPS" id="S46.002"/>
    <dbReference type="EnsemblBacteria" id="ACU08947">
        <property type="protein sequence ID" value="ACU08947"/>
        <property type="gene ID" value="FIC_02517"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02517"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013776_0_0_10"/>
    <dbReference type="OMA" id="PGRTNRW"/>
    <dbReference type="OrthoDB" id="99817at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070009">
        <property type="term" value="F:serine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019500">
        <property type="entry name" value="Pep_S46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38469">
        <property type="entry name" value="PTHR38469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10459">
        <property type="entry name" value="Peptidase_S46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023152514" description="Dipeptidyl-peptidase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="712" mass="79762" checksum="134290BED6E5C156" modified="2009-09-22" version="1">MKRIFLLLTFSLSFLQLKADEGMWLMTMIKRLNGVDLQKQGLKLTPEEIYSVNKSSLKDAIVQFGGGCTAEMVSKEGLLFTNHHCGYGQIAELSTPEKDHLTNGFWAMKKSEELPAKGLSVRFLVRMDDATQRINSKLNSGMSAEARKAVIDAEYKAIQAENGENGKYTVVVRDFFNGNEFYYFVYQDFKDVRLVGTPPNALGKFGGDTDNWEWPRHTADFSVFRVYADANGNPAEYSPNNVPMKPKHSLPISLKGYKPGDFTMIVGFPGRTNRYLTSYGIEQMVTKDYPAWVEASKVAMDVMKKHMDTDQATKLDYASQYASVANYWKNRQGTIDAVNKNGTIADKRKLEDKFLVWALLPENEAVYGNVLNDLRANYAQISNRNVERNYSSQLQRNAKYIMVAYQLGSMLKTYADQDAAGQAAMKTKVSDAIDRMYDGFNPKLEGDMLSAMVSLYQQRVKKDDGSPAIFAAEATALPTVAYSSIFATKESALNFLNNPDRLKIDADPLMKLANGYVNEQKLVGEKYAKVDEAFATNSRIFLDGLRKSQPETAFYPDANSTMRLTTGSVQTLPVRTDRNYAGINQKNNYYTEINGMVAKYKKGDEEFDLPQDFLDLVKRKDFGQYKDKKGFMPVNFLSNNDITGGNSGSPILDGNGHLLGLAFDGNSEALSGDIIFDPALQKTINVDVRMVLWIIEKYGKAGHLISEMTLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3J2</accession>
    <name>C6X3J2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU09005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807289.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02575"/>
    <dbReference type="EnsemblBacteria" id="ACU09005">
        <property type="protein sequence ID" value="ACU09005"/>
        <property type="gene ID" value="FIC_02575"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02575"/>
    <dbReference type="eggNOG" id="ENOG5032XX9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865318_0_0_10"/>
    <dbReference type="OMA" id="FEFANAK"/>
    <dbReference type="OrthoDB" id="1610379at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU09005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="321" mass="37428" checksum="FF32D73074EDC8A0" modified="2009-09-22" version="1">MANFQNLQQKVFFEVKTILETLSKVSSVEELMTKQELSSELADRISFLRILDKNEDSFAQNNASQDADHQNLTFSDDREMIAEDDGYFDGLAQDDESIEEEVIFTNEINEIENEPEFPESSNTSPEAETEHFEELIDDAAQEVAYEDRVAQKEQELEARRRQIVEFSKKETDHPTQDQIERSETLTPSEKKFKLAHIKGLKAVQNLFDDDPLEKLYEDETESADNRHDTGSIVKSNIPTDFMEAQRKRTEFRLDLNDKVAFTKLLFKGQEAELTKAIARLNSFDNIEDARQYLSELYYAKDWKKADEYAQRLWNLVENKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3L7</accession>
    <name>C6X3L7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00547"/>
    <dbReference type="EnsemblBacteria" id="ACU07005">
        <property type="protein sequence ID" value="ACU07005"/>
        <property type="gene ID" value="FIC_00547"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00547"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119548_1_0_10"/>
    <dbReference type="OMA" id="TDATENW"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668836" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="175" mass="20078" checksum="0D295BDE8B7B3990" modified="2009-09-22" version="1">MIMKNLNLLAIVVMIFGFSLSAKAQNKGFYESVQKKNVSKVLDDLNMYAAKTDFKNYFDLFAEESTFIGTDATEVWNKQDFMVWAKPYFDKGQAWNFTSLKRTITFSKDGTYAWFDEMLDTQMKICRGSGVLEKVGGKWKIKQYVLSMTVPNDVSNEVIGIKTPIEDKLLQTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3V4</accession>
    <name>C6X3V4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782238.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07092">
        <property type="protein sequence ID" value="ACU07092"/>
        <property type="gene ID" value="FIC_00637"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00637"/>
    <dbReference type="eggNOG" id="ENOG502Z8F7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107096_0_0_10"/>
    <dbReference type="OMA" id="IWTETDF"/>
    <dbReference type="OrthoDB" id="1397945at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="225" mass="27390" checksum="871CB3631ED78135" modified="2009-09-22" version="1">MGKYELEKKIWTETDFEKMGWHDCRIYKIRLTDNLELDIDYILQWNKPDIEGLPFTFWAAPATLVFKKISNIQFEIDTAFDEAVEIEDIELSKSDNKLQWTIITQQGDIEFEADGFTQWIRQEPFFQFGQTISYIERCGFSLEQTTDQDNPNRIRQDIVEQQKKDFEHYENVKKRQLKRKEKSDLEDQRENGKIDLKDYLTKKKEIKEMLDYYDYWLKNTRFENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3X2</accession>
    <name>C6X3X2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphinothricin N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782256.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00655"/>
    <dbReference type="EnsemblBacteria" id="ACU07110">
        <property type="protein sequence ID" value="ACU07110"/>
        <property type="gene ID" value="FIC_00655"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00655"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_4_5_10"/>
    <dbReference type="OMA" id="EAAGIWT"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="165" mass="18490" checksum="3E2208A23E1B16C7" modified="2009-09-22" version="1">MKFRIREMKPSDGPNVLTIFGEGIEGGNATFDRDVPSLEAWDSKFFKCCRFVAEDQNNNVAGWAAIQPVSKRDCFTGVAEVSIYISNAVQGQGLGLDLLRKLVEESEAHGYWTLQAGIFPENVASIKIHEKLGFRTVGIRQRLAQMKGVWRDVLLMERRSEIVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Y4</accession>
    <name>C6X3Y4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782268.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00667"/>
    <dbReference type="EnsemblBacteria" id="ACU07122">
        <property type="protein sequence ID" value="ACU07122"/>
        <property type="gene ID" value="FIC_00667"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00667"/>
    <dbReference type="eggNOG" id="COG3800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533901_0_0_10"/>
    <dbReference type="OMA" id="EHYCRRW"/>
    <dbReference type="OrthoDB" id="195775at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="491" mass="56856" checksum="7A749E6FD3BA004A" modified="2009-09-22" version="1">MNSDPAYIKLVFGLKMKQYRKIKNLSLQDLATLTGLSKSYLNEIENGKKYPKHDKIIPLATALGCTYNDLVSTKSDKSLAPILEIVQSDFFKEIPLDLFGINRNNLVSIISDAPKKVKAFVNTLIEISKNYNVRKENFYFAVLRSFQELQDNYFPQIEEAALQYAGENLLSLNPRSHRLQQLLQEQFQYDIREQNLVFYGASGKLRSLYIPEKKLLLLNTLLTENQKTFILAKEIGFQVMNLQTRPHTYSWLDFKSFEELLNNYYASYFAGCLLIPRRILTHKITDFLQLPRWEPEYFEQLTAEFTDSPETFYYRLTNILPQDLGIKDLFYLCFTKKKNSDEVQILKELHLNQQQAPHANATSEHYCRRWIAVKNLYNLAENETLTASQFSHYKDTGLTYLVISTSQKNPFSDGTNRSYCLGILLNSSSAKKIGFLKSENIKTINVGVTCESCSILDCEVRQAPPERLEKEMLNQNMLKSVQAIRNEFLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>C6X3Z8</accession>
    <name>C6X3Z8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FIC_00681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782282.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00681"/>
    <dbReference type="EnsemblBacteria" id="ACU07136">
        <property type="protein sequence ID" value="ACU07136"/>
        <property type="gene ID" value="FIC_00681"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00681"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_10"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="PTHR10836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU07136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="334" mass="35911" checksum="C5255FC3A68B03EB" modified="2009-09-22" version="1">MSTIKVGINGFGRIGRLVFRAMAERENIEVVGINDLIDAKYMAYMLKYDSVHGTFAGEVSVEGNDLIVNGKKIRVTAEKDPNNLKWNEVGAEYIVESTGLFLTKEAAQAHINAGAKKAILSAPSKDDTPMFVMGVNHKDLTDDVTIFSNASCTTNCLAPLAKVLHDNFGIIEGLMTTVHATTATQKTVDGPSMKDWRGGRSALNNIIPSSTGAAKAVGKVIPALNGKLTGMSFRVPTADVSVVDLTVRLEKSTSYEEICAAMKAASEGELKGILGYTEDAVVSQDFVGEKRTSVFDKDAGIMLSPNFVKVVSWYDNEMGYSNKLADMLVHSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X406</accession>
    <name>C6X406_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782290.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00689"/>
    <dbReference type="EnsemblBacteria" id="ACU07144">
        <property type="protein sequence ID" value="ACU07144"/>
        <property type="gene ID" value="FIC_00689"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00689"/>
    <dbReference type="eggNOG" id="ENOG502Z8PA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923456_0_0_10"/>
    <dbReference type="OMA" id="YANESQY"/>
    <dbReference type="OrthoDB" id="1273059at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045625">
        <property type="entry name" value="DUF6427"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19992">
        <property type="entry name" value="DUF6427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="302" mass="34669" checksum="061382CCAA4C6F2B" modified="2009-09-22" version="1">MFRLLSKESNIFSVPVYIGVLLLIVIAFNILDFSTLDVFSAAITFGGIALGYFCFNAIALNYQTHLPLFLYTAFVFAWYPGDLDIGIAVSLFTNSIIILLLTNVDMTVRKHSYVLVGAILALNFIFLPTTWPMSLFVIFHIIGTSDRIGLHFFRLIFGMFLVASSYFGVAFFLGYNAWNPAYFPFGKFSPSPYLNDLVWLLPVALLLIHAVWDHFRNFNRKSPISKFKYTFLLVFSLAQLITIVLYMGENYEYLLLLTFPVSIILSRMLKFLPKPWMQESAFWLLIFSLLVFKLADFFTLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X408</accession>
    <name>C6X408_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Universal stress protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_00691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782292.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00691"/>
    <dbReference type="EnsemblBacteria" id="ACU07146">
        <property type="protein sequence ID" value="ACU07146"/>
        <property type="gene ID" value="FIC_00691"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00691"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_10"/>
    <dbReference type="OMA" id="YIVMGSH"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="145" mass="16193" checksum="1F04607A08E8320B" modified="2009-09-22" version="1">MINIVLPIDFGESTDRLIDAAVKFAHEMNGRICLIHVAPADIGFAIGDMGFQYFPEVEQNEIKEELQQLNKIEQRITAQNIDCEHLLKQGVAGDIILEYAKEKNAGYIVMGSHGRSGIYDVFVGSLTKELTRRSTIPVLVIPIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X433</accession>
    <name>C6X433_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR/glycosyl transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782317.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00716"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07171">
        <property type="protein sequence ID" value="ACU07171"/>
        <property type="gene ID" value="FIC_00716"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00716"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032377_0_0_10"/>
    <dbReference type="OMA" id="ADFRDPW"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="430" mass="49529" checksum="2D92E998A005C022" modified="2009-09-22" version="1">MENKKILIITYYWPPAGGPGVQRWLKFVKYLPEFGWKPTIFIPENPNYPIVDETLKSEVADDLEIIRNRIWEPYQIAEFFGKENKKFKAGQFDVGTNQSWKSKLSVWVRGNFFIPDARVFWVKPSARLLKAYLKENHFDAIVTTGPPHSVHLIGLKLKKEFPDLKWIADFRDPWTEISYYKHLKLTKSADLKHRTLEQQVFKTADITLATSFSDSENFAEKGANAVCITNGFDEVESVTYEKSTKFTLSYVGVLEQLRNPDILWEVLNGILFENPAFSDDFEFKCVGRIDDKILRKINSSPLKNSLRNLGYLSHAEANREMRNSDLLLITNFPDEASKGIIPGKIFEYLATGNQILSFGPKDSDVKIILAETNAGQHFTYDDAAALKVFILQQYENWKSGNLQQETRNIDRFSRKYLTGKLTEILDREPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X443</accession>
    <name>C6X443_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00726"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07181">
        <property type="protein sequence ID" value="ACU07181"/>
        <property type="gene ID" value="FIC_00726"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00726"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076334_0_0_10"/>
    <dbReference type="OMA" id="CKFDADL"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="296" mass="34628" checksum="B6FA2F4BBF864C93" modified="2009-09-22" version="1">MMKFLIIIPAHNEEENILFCLESLHNQTFKDYNVVVVNDGSTDHTHELVEKFVLKNPDFKIQNLEKSEHQPGAKVVRTFNKGLETVDISAFDIICKFDADIIFPPDYLEKINAEYMQNPKIGMVSGIVKIKNSAFEEENAFSFHNETDRWQFENISSKNHVRGPIKSYRKDCFTDMNGLRPVLGWDNIDVMLAQKHGWEVQTIKDLWVKHLRPTAYKYKQQKAEKLGEYFYNIGLNLPLAIVSSAKSSFKNKSISEFFITILSFSKQNSKRQLSQEEIHFIRTLRWNQIFNKKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X474</accession>
    <name>C6X474_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00757"/>
    <dbReference type="EnsemblBacteria" id="ACU07212">
        <property type="protein sequence ID" value="ACU07212"/>
        <property type="gene ID" value="FIC_00757"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00757"/>
    <dbReference type="eggNOG" id="ENOG502ZSBD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123905_1_0_10"/>
    <dbReference type="OMA" id="NDTSKEC"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13648">
        <property type="entry name" value="Lipocalin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973558" description="Lipocalin-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="170" mass="18563" checksum="4CAD6A0768FADAC2" modified="2009-09-22" version="1">MCTSVVNNFITMKNLLVAGILGAALTVSCSTAKTAQANRAEFLQLKGDWEITSVDYDKSYKVRPFDEGADAQCFVGSHWRLIPNNWTGSYTLNGGGACPSVIQPIKFEVVNGSEFKFKKLLEGSKAKAVVEGYSLNLTSQTEDSFSLEQNVPSAGENVRIVYNFSRTGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X477</accession>
    <name>C6X477_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00760"/>
    <dbReference type="EnsemblBacteria" id="ACU07215">
        <property type="protein sequence ID" value="ACU07215"/>
        <property type="gene ID" value="FIC_00760"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00760"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032465_0_0_10"/>
    <dbReference type="OMA" id="YTVAWID"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="451" mass="51277" checksum="E3943AF619B499DD" modified="2009-09-22" version="1">MACGLFTSNLFQIMKPNYIQKVANWGNFPVVEKEIKSEDSIEKIKEFVRNNDEIIARGNGRCYGDAALSEHIFSTKRLNKFISFDRLNGIIECESGVLLSEVLEVIVPQGYFLYVTPGTKFITVGGAIASDVHGKNHHAEGCFSEYVLEFSLLIESGDVIICSRTQNTAKFWATIGGMGLTGIILQAKFKLKNVETAYIRQESIKAKNLDEIFKLFDESESWTYNVAWIDCLQKGENIGRSILMRGEHAFKHQLTAKLAEKPLRLTKKFTPTVPFFLPGFLLNIYTVKLFNFLYFNRQRRASVQNYVDYETFFYPLDIVNDWNKMYGKKGFIQYQLVLPKENGKEGMRKILEAIGSSGNGSFLAVLKLLGKNNPDAHNSFPIEGYTLALDFKVNSSLKNLVQRLDSIVEEYAGRIYLTKDSMSKSSLTDYLQHVENPKFVSLQHKRIISNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X493</accession>
    <name>C6X493_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07231">
        <property type="protein sequence ID" value="ACU07231"/>
        <property type="gene ID" value="FIC_00778"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00778"/>
    <dbReference type="HOGENOM" id="CLU_3403660_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="30" mass="3575" checksum="4B069EAA66F57613" modified="2009-09-22" version="1">MTAILPNFNQRMEAKIQKNGSEILPWFYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4B9</accession>
    <name>C6X4B9_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kbl</name>
        <name evidence="4" type="ordered locus">FIC_00804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00804"/>
    <dbReference type="EnsemblBacteria" id="ACU07257">
        <property type="protein sequence ID" value="ACU07257"/>
        <property type="gene ID" value="FIC_00804"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00804"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_10"/>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="57"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="288"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="411" mass="45324" checksum="7977CBFE4C70A77B" modified="2009-09-22" version="1">MRAFSYFSNSKPTTMISEKFTNTLQNELTNIKNDGLFKTERIITSQQSAEIEANGKKLLNFCANNYLGLSNHPEVMKASQDMIESHGYGMSSVRFICGTQDIHKELEAKISTFLGMEDTLLYAACFDANGGVFEPLFSAEDAIISDELNHASIIDGVRLCKAARYRYKNNNMEDLEAQLKIATEKNHRFRIIVTDGVFSMDGIVADLKGLCDLADKYDCLVMVDDSHATGFIGKTGRGTHEANDVMGRVDIITSTLGKALGGALGGFTSGKKEIIDMLRQRSRPYLFSNSLAPGIVGAAMKVLEMISDDTGLRDQVMENAEYFRTKMQALGFDIPEGDAAIVPVMLYDAPLAQKMAEKLMDEGIYVIGFFYPVVPKGKARIRVQLSAAHTKEHLDKAIAAFEKVGKELNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4C5</accession>
    <name>C6X4C5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Aspartate ammonia-lyase</fullName>
            <shortName evidence="5">Aspartase</shortName>
            <ecNumber evidence="3 5">4.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_00810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-aspartate = fumarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16601"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="4.3.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782409.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00810"/>
    <dbReference type="EnsemblBacteria" id="ACU07263">
        <property type="protein sequence ID" value="ACU07263"/>
        <property type="gene ID" value="FIC_00810"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00810"/>
    <dbReference type="eggNOG" id="COG1027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_0_10"/>
    <dbReference type="OMA" id="EICENYV"/>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006531">
        <property type="term" value="P:aspartate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004708">
        <property type="entry name" value="ApsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00839">
        <property type="entry name" value="aspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="12"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="7">
        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="470" mass="51763" checksum="CD97CEE802CE800C" modified="2009-09-22" version="1">MENFRIESDLLGELKVPIDAYYGVQTQRAVDNFYITGRKMGEYPEFVKAIGYVKLAAVQTNHALGLIDDKMLDVISEACQDVIDGKFRDQFPVDMIQGGAGTSVNMNANEVLANRALEIMGFEKGDYQHCYPNDHLNLSQSTNDVYPTTVKLAIIMMNHNLVEHLRKLNHSFREKGKEFHDVIKMGRTQLQDAVPMTLGQEFEAFAANLDEEIILLNNISNLFLEINMGGTAIGTGLNAPEGYPILCAERLAALTGEDFVSAANLVEATPDTGSFLIYSSVLKRTAVKLSKICNDLRLLSSGPRAGLNEINLPPMQPGSSIMPGKVNPVIPEVVNQVCFKVIGNDLTVTLAAQAGQLQLNVMEPVLSECIIESIIFLERAMDTLRTKCIDGITANREVCKNMVKNSIGIVTALNPYIGYKTSTKIAQEAMETGKSVYDLVLEHKILSQEKLDEILDPKNMLSSHAFVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4P9</accession>
    <name>C6X4P9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782533.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00936"/>
    <dbReference type="EnsemblBacteria" id="ACU07387">
        <property type="protein sequence ID" value="ACU07387"/>
        <property type="gene ID" value="FIC_00936"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00936"/>
    <dbReference type="eggNOG" id="ENOG50331EZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176977_1_0_10"/>
    <dbReference type="OMA" id="GFGITIY"/>
    <dbReference type="OrthoDB" id="2049203at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021448">
        <property type="entry name" value="DUF3098"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11297">
        <property type="entry name" value="DUF3098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="101" mass="11332" checksum="5DFB150EFEB091E7" modified="2009-09-22" version="1">MAKKYKSFSADTIGKKDADVPQKNSFYFGHENYKLMLIGLALIVVGFLLMMGADANTVDGKYDPNSWNEGIFSIRRIRIAPLLVVAGFVVEVYAILKRKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q4</accession>
    <name>C6X4Q4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782538.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00941"/>
    <dbReference type="EnsemblBacteria" id="ACU07392">
        <property type="protein sequence ID" value="ACU07392"/>
        <property type="gene ID" value="FIC_00941"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00941"/>
    <dbReference type="eggNOG" id="ENOG503274K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642135_0_0_10"/>
    <dbReference type="OMA" id="DIENEYY"/>
    <dbReference type="OrthoDB" id="1432368at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025935">
        <property type="entry name" value="AbiH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14253">
        <property type="entry name" value="AbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="427" mass="50878" checksum="07F144A199E2AA42" modified="2009-09-22" version="1">MNRIILIGNGFDLAHNINTTYFNFLNHFWEELYVKIQADDYRDKRYEDEFIIIDKVPSHWISGKGYKALKSTLSNTHTALRFKNKFLENLSRGIESLNWVDIESDYYSFLKDCFKKPHLRYTIAELNEDFSVIKKHLELYLEQVEKEFNKKFPVDEDDNILRRNIYNEIYSDFKLRDFSEDSINKLTEQEFQRIHPSVKALENDHATIQEVSENHRDRKLIADLYHTEEKNRRRKLRELLVSEASPNYFRSRPKEILFLSFNYTSLETKYNSAPNDEEGLERIPTSTIHIHGELGNDNNNKIIFGFGDEIDKDYKTIEDLDDNKYLENIKSIKYLESISYKSLLQFINSDDYQIFIFGHSCGISDRTLLNTLFENKHCTSIKPFYRQKDENTDNYSEIIKNITRNFTNKAALRDRVVNKVYTRPLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Q7</accession>
    <name>C6X4Q7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_00944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782541.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00944"/>
    <dbReference type="EnsemblBacteria" id="ACU07395">
        <property type="protein sequence ID" value="ACU07395"/>
        <property type="gene ID" value="FIC_00944"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00944"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_10"/>
    <dbReference type="OMA" id="DYYWGMG"/>
    <dbReference type="OrthoDB" id="330994at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="392" mass="42210" checksum="48B514A9D35D713D" modified="2009-09-22" version="1">MKQAYIIKGFRTAVGKAPKGSLRFTRPDVLAATVIEKLMAAVPQLDKDRIDDLIVGNAMPEAEQGLNVARLISLMGLNTDKVPGVTVNRYCASGSEAIAIASAKIQAGMADCIIAGGTESMSYIPMGGYKPVPETDVAKSHPDYYWGMGYTAEEVANQYKISREEQDQFAFESHMKALKANEEGRFANQIVSIPVEYNFLDEDQKMQTKKFDFSVDEGPRKDTSLEGLAKLRPVFANGGSVTAGNSSQMSDGAAFVIVMSEDMVKELGLEPEARLVAYSAAGLEPRIMGMGPLYAIPKALKQAGLDLKDIDLIEMNEAFASQSVAIIKELDINKEILNVNGGAIALGHPLGCTGTKLTVQLLDEMRTRGNKYGMVTMCVGTGQGAASIFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4V7</accession>
    <name>C6X4V7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00994"/>
    <dbReference type="EnsemblBacteria" id="ACU07445">
        <property type="protein sequence ID" value="ACU07445"/>
        <property type="gene ID" value="FIC_00994"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00994"/>
    <dbReference type="eggNOG" id="ENOG502ZAEC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110629_0_0_10"/>
    <dbReference type="OMA" id="KFPYDRE"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972308" evidence="1">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="213" mass="23687" checksum="B35223FFC2191B05" modified="2009-09-22" version="1">MIKIVMKKILPFFIAVAIALTACQPVYKADNFQQTANTHRLIAVLPPKVIIEIKSADEAAAIKKQEMIESERFQNALVNYLNEQNHENKIFIKAQNTAETNKILADNNVTSLTGRSYGELAKMLGADAVVTSRISLAKPLTNSEAFFTSLLTGYSAPSKITTVDLSLTDRESGKMFWNYNWQTGGTFVSTEKLTNSLMKAAAIRFPYKTKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y8</accession>
    <name>C6X4Y8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782622.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01026"/>
    <dbReference type="EnsemblBacteria" id="ACU07476">
        <property type="protein sequence ID" value="ACU07476"/>
        <property type="gene ID" value="FIC_01026"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01026"/>
    <dbReference type="eggNOG" id="COG4637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033692_0_0_10"/>
    <dbReference type="OMA" id="SINDNCQ"/>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="357" mass="41395" checksum="C7A914456D2838E0" modified="2009-09-22" version="1">MIRSLYVEELNGRKTPLNLQFNSDLNLLTGKNGSSKTTLLKLIWYLNSARINSLIKEVNFTRAIITTDNYKLDLTKDSESRYVNISINDEKSFTLSDQNLRELDYRRPIRINEKLNIIIKNSIPTIFFPTFRRIEGGFSMDNNQFDPLFGRNDEVRDALEELSRKLSFRNQRFITSISTDDIVALLNSEYTNINSKINNTQKQKSDEIIRKIKDKIQDEKQTLENIKKDIEDMESEREKLLKPFTTLSNLISTIFHHKGINLSNLTIGEVNNAISSDKLSAGEKQMLSFICYNAFTKNHTIFIDEPELSLHPDWQRTLVPTLLNQDSNNQFFMATHSPFIFSKYADKEIILSDDKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4Y9</accession>
    <name>C6X4Y9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07477">
        <property type="protein sequence ID" value="ACU07477"/>
        <property type="gene ID" value="FIC_01027"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01027"/>
    <dbReference type="HOGENOM" id="CLU_3290007_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="40" mass="4409" checksum="E72D97848A412E1F" modified="2009-09-22" version="1">MLSAHRQGAVAEFSESLMHVHNKLAGLPECCTTKQPKVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C6X509</accession>
    <name>C6X509_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01047"/>
    <dbReference type="EnsemblBacteria" id="ACU07497">
        <property type="protein sequence ID" value="ACU07497"/>
        <property type="gene ID" value="FIC_01047"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01047"/>
    <dbReference type="eggNOG" id="COG3544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074343_2_1_10"/>
    <dbReference type="OMA" id="IPHHQDA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973698" evidence="2">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="86"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="228" mass="25680" checksum="F1992BDC236124BE" modified="2009-09-22" version="1">MHTLIKNIVMRKLFIPTLAAFLMLSCDKSYEKTAQTTAETTTDHTAGHSSEHMADSAAQTNKNEMLAEMDEMMREMHSAKFSGNIDADFAEMMADHHDGAVEMSEILLQKGTDAELKDFAAKVVAAQNKEIAILDRFDDAVGVSAENVAFQKDLQRSMAAMMDKNIKIHNDIDKDYAQQMIPHHQSAVDMAKVYLKYGKQKELLKLCNDIISTQTSEIDYLKDWLAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C6X543</accession>
    <name>C6X543_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01081"/>
    <dbReference type="EnsemblBacteria" id="ACU07531">
        <property type="protein sequence ID" value="ACU07531"/>
        <property type="gene ID" value="FIC_01081"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01081"/>
    <dbReference type="eggNOG" id="COG3685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370405_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="1">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="199" mass="22298" checksum="825371EACC107484" modified="2009-09-22" version="1">MVIMLNRTAINLAFASQTGTYNTIMVNMAPGDNADSLCVSTLQLFLHDMLKELYFAQVAIDTSFTSTEGQVSSPKLETILKNHSLINLNHEKRLTTIFNLLDIPVEYKDSVHVTALLVETENHLNMCAKDRITWEITLIISARKVARYKMTAYEVASHLAIILGHTQVATLLAVSAQEEEEFILRFLDGLTHEFSAPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C6X558</accession>
    <name>C6X558_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07546">
        <property type="protein sequence ID" value="ACU07546"/>
        <property type="gene ID" value="FIC_01096"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01096"/>
    <dbReference type="HOGENOM" id="CLU_3118083_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="50" mass="5580" checksum="39C2F0AB104BC82C" modified="2009-09-22" version="1">MLPCLDSGLKLINFILVIVLFSGEFTQQIEKSQSSGKNGDLIQLRNDQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5A2</accession>
    <name>C6X5A2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01140"/>
    <dbReference type="EnsemblBacteria" id="ACU07590">
        <property type="protein sequence ID" value="ACU07590"/>
        <property type="gene ID" value="FIC_01140"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01140"/>
    <dbReference type="eggNOG" id="COG4815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111604_2_0_10"/>
    <dbReference type="OMA" id="LMIAVES"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011235">
        <property type="entry name" value="MepB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038231">
        <property type="entry name" value="MepB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08877">
        <property type="entry name" value="MepB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032285">
        <property type="entry name" value="UCP032285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="120" mass="13780" checksum="A151C70572FE60B6" modified="2009-09-22" version="1">MIFRKAKITPAKNGQFVTCWKRNGEGITQPFESSDDFEFLMIAVESGNRSGVFIFPKKVLEAQKIVMNELSRGKRGIRVYPSWDTTASRQADKTQKWQLEHFFETPIGKSVTVSERDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5B3</accession>
    <name>C6X5B3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.61" evidence="1"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805886.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01151"/>
    <dbReference type="EnsemblBacteria" id="ACU07601">
        <property type="protein sequence ID" value="ACU07601"/>
        <property type="gene ID" value="FIC_01151"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01151"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1508472_0_0_10"/>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004808">
        <property type="term" value="F:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="178" mass="19762" checksum="52755713D4411375" modified="2009-09-22" version="1">MIKGQLVEIPATSALYHSPRPDQMTRPDVLRGLSPHHRYSLFDGFLVGEHRGTSTFQLGQRKRIGVGGKSAPLYVIGIDDAENRVFVGHGDDHPGLLSKVLCFKASQFHLVQNPSFNQNLSEEATPVDVVFSDGKRAEANIYCFGSELFLEFKKPVPIRFSASNISVFKEDTLIANIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C5</accession>
    <name>C6X5C5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA topoisomerase IB (Poxvirus type)</fullName>
            <ecNumber evidence="3">5.99.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.99.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805898.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01163"/>
    <dbReference type="EnsemblBacteria" id="ACU07613">
        <property type="protein sequence ID" value="ACU07613"/>
        <property type="gene ID" value="FIC_01163"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01163"/>
    <dbReference type="eggNOG" id="COG3569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046978_1_1_10"/>
    <dbReference type="OMA" id="QYRYHPR"/>
    <dbReference type="OrthoDB" id="812517at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisom_I" evidence="2">
        <location>
            <begin position="115"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="368" mass="42284" checksum="04274697613D4162" modified="2009-09-22" version="1">MNTPETDLVASLTPAKIVKIMKDPVKSAKAVRLIYTNDRETSGIIRKKSRDKFIYFNGEEKVKDKDEITRINKLAIPPAWENVWICGIENGHLQATGIDAKNRKQYRYHPVWNALRNHTKFYRMLQFGYALPKIRLNLEKDLSLKTLEKRKVLAVVVSLMERTNIRIGNSVYEKLYGSFGLTTLKDKHVQITGQKINLSFKGKKGIYHDIDLRNRKLAKAVQNCKDIPGKELFQYYDADGKRHAIDSGMVNEYIKEISGEDFTAKDFRTWSGTVNALIAFKEIGAAESDKTYKSKVKEALEMVASHLGNTATVCRKYYVHPLVINLYENNSIRKYLDELDEIEVDDGKSGLTREEKIVMKILENEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5H7</accession>
    <name>C6X5H7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07665">
        <property type="protein sequence ID" value="ACU07665"/>
        <property type="gene ID" value="FIC_01217"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01217"/>
    <dbReference type="eggNOG" id="ENOG50334FN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432029_0_0_10"/>
    <dbReference type="OMA" id="TERISWD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="189" mass="22062" checksum="7279FA0CF7213819" modified="2009-09-22" version="1">MTTKKRYEILTSLPTYGPMYVPVTDNGEPFYSEGFPVRFYKTDQTEWVVNFQPGWTELKQIIEFEKTQNLLIIACGTCYLMNPNETKPIEVFGVGYSDIFKASKDRLVFQDQTDLTIIEPDGTHWNTERISWDGLAEINVENNLVSGLAYNPMPDSDEWVEFKYDLDTKTLTGGSYYSFENKKPWWKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5J6</accession>
    <name>C6X5J6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07684">
        <property type="protein sequence ID" value="ACU07684"/>
        <property type="gene ID" value="FIC_01236"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01236"/>
    <dbReference type="eggNOG" id="ENOG5033GF9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186664_0_0_10"/>
    <dbReference type="OMA" id="YAYHENE"/>
    <dbReference type="OrthoDB" id="2075950at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045391">
        <property type="entry name" value="DUF6520"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20130">
        <property type="entry name" value="DUF6520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973721" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="91" mass="9698" checksum="9343A96EB856FDF8" modified="2009-09-22" version="1">MKNVKTLLLPAIMVFVGAGSAYATHNVKQSEKALVRGYAYHENEAQPCVASEKFCDTSGVFICTGDVGMGTEDLYNINGTACPNVLTHTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K0</accession>
    <name>C6X5K0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805973.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07688">
        <property type="protein sequence ID" value="ACU07688"/>
        <property type="gene ID" value="FIC_01240"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01240"/>
    <dbReference type="HOGENOM" id="CLU_2806166_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="67" mass="7717" checksum="ED4FC34B5A0D1A02" modified="2009-09-22" version="1">MSGGNDVESEEHWSLPPEFERFSEKEQEFFSKKDPSLDLFVTFCIKAKSNRNMLAKTDLGDFGVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K6</accession>
    <name>C6X5K6_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01246"/>
    <dbReference type="EnsemblBacteria" id="ACU07694">
        <property type="protein sequence ID" value="ACU07694"/>
        <property type="gene ID" value="FIC_01246"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01246"/>
    <dbReference type="HOGENOM" id="CLU_3061771_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="53" mass="6125" checksum="6BE2AD2F3DDBAB19" modified="2009-09-22" version="1">MCSGRHFSMKGMRLKMSRPYVAGPQVGLNRSNKRRYETTGQSIFLTMHYTAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5K7</accession>
    <name>C6X5K7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU07695">
        <property type="protein sequence ID" value="ACU07695"/>
        <property type="gene ID" value="FIC_01247"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01247"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_2_0_10"/>
    <dbReference type="OMA" id="YAYGFIM"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="265" mass="28322" checksum="E5ABF2C7EBF651D7" modified="2009-09-22" version="1">MPLKICALPETEILIYLCLAAFAAGFIDAVVGGGGLIQTPLALAFLPHLPVATVIGSLKVPAFSGTAIATSQYLKMVKIDWKLLILMAVLAFVSAFLGSRLLTIVSNEFMKPVLLFVLIALALYTIFKKNFGNATEKKIPYHIAIINGCIASIAVGFYDGFIGPATGTFFILAFVTLLGMDFLKASANAKLINLATNAGSICLFLLKGQIIWAIALPMAVCNALGGLVGSRLAIRRGNKFIRLLFIFVLVLAIGRFGYEVVKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5L3</accession>
    <name>C6X5L3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805986.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01253"/>
    <dbReference type="EnsemblBacteria" id="ACU07701">
        <property type="protein sequence ID" value="ACU07701"/>
        <property type="gene ID" value="FIC_01253"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01253"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_1_10"/>
    <dbReference type="OMA" id="AISHESN"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="303" mass="33805" checksum="536EEBFC95AF5227" modified="2009-09-22" version="1">MSPTILKTLLVPTGFSAKCENALRLAAEMAQRHDAKIILFHVVPLQYLIDRTGRQIIGGDTTQITIEQAAEKLLSYKEALVANHPGLQIETHVKTGMLPDVVNDLTVSASADLVILGTSGEQKWKQMILGSYSYDILRDAPCPVLLVPQLFEKRAFCNILFPVRVTDYLELKLELAVAIAERNHAHINLYGVCDADNLEEIRERFKVAEAGFKDKVRSFRSELVLTDDKAEAISHESNEKDCDLVILSHKDEFVWKSVLLENFFRKIINGTDAALLFVKPRLIGTTEIQDGGTSYDITMPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M2</accession>
    <name>C6X5M2_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01262"/>
    <dbReference type="EnsemblBacteria" id="ACU07710">
        <property type="protein sequence ID" value="ACU07710"/>
        <property type="gene ID" value="FIC_01262"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01262"/>
    <dbReference type="HOGENOM" id="CLU_3389557_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="32" mass="3859" checksum="73F31AE47536D4EB" modified="2009-09-22" version="1">MKHKNGQYQHSQAVVVPEKRKTYFLGERILSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M3</accession>
    <name>C6X5M3_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805996.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01263"/>
    <dbReference type="EnsemblBacteria" id="ACU07711">
        <property type="protein sequence ID" value="ACU07711"/>
        <property type="gene ID" value="FIC_01263"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01263"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030408_4_0_10"/>
    <dbReference type="OMA" id="VRINDKW"/>
    <dbReference type="OrthoDB" id="1951208at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970706" evidence="1">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="282" mass="31636" checksum="5E5F6766779C8C6B" modified="2009-09-22" version="1">MKKRVWATPFLCFVCVLTQAQESYKQNEKWGFKDKDGNAIVTAKYDYAYDFTEGLGAVRINDKWGFVDKDGKEVVPLKYDAVTEFADGMAAVEKDDKWGFIDKTGMALTALKYDDIEDFSQGLVAVEINEKWGFVDKTGKEVIPVKYDQVGVISEGLIGVWLDDTAGFIDASDKVVIPFEYEWVLDFSEGLAGVSRGDKAGFINNSNKAVIRLKYDYVESFSHGLAPVSKNDKWGYVNKAGKEITPIKYDGVSVLDDGKATAELDGMIFYIDKKTGKEERFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M7</accession>
    <name>C6X5M7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806000.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01267"/>
    <dbReference type="EnsemblBacteria" id="ACU07715">
        <property type="protein sequence ID" value="ACU07715"/>
        <property type="gene ID" value="FIC_01267"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01267"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_0_10"/>
    <dbReference type="OMA" id="GRQHEYF"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="121" mass="14334" checksum="F3BC27688585484B" modified="2009-09-22" version="1">MQFTQLTKAEEQVMQYLWEIRKGFLKDILERFPDPKPHTNTVSTILKVLKEKNFVDYEVYGRQHEYFPVVSKEKYSGKSMKSLVKDYFEGSYKNAVSFLVEKNEISVQDLELLLDELKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5S5</accession>
    <name>C6X5S5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01315"/>
    <dbReference type="EnsemblBacteria" id="ACU07763">
        <property type="protein sequence ID" value="ACU07763"/>
        <property type="gene ID" value="FIC_01315"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01315"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_30_0_10"/>
    <dbReference type="OMA" id="FKSVTMD"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="234" mass="27614" checksum="C75CEA9DE2616DCA" modified="2009-09-22" version="1">MVATFCRKTFSILKKTWKLLLFLSFPSYLCTRIMDEKQNFLSKASSLFIENGPKAVTMDDVATAFGISKKTLYQKYRNKEELIEEIMQYNLDLVISKLNELDDNIENAMERMLCRDVEIEKISHSNKTLLIRQLMKYYPGIFNKHMLSFSERFSAVLVRNIEKGRKQGCYRDDFDAEIYAKIFFQLVMSYDSSPYIDTAEVDRLHYKEELMMMYMHAIATEKGKETIKKIKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5W1</accession>
    <name>C6X5W1_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">FIC_01351</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806084.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01351"/>
    <dbReference type="EnsemblBacteria" id="ACU07799">
        <property type="protein sequence ID" value="ACU07799"/>
        <property type="gene ID" value="FIC_01351"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01351"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_2_10"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 16" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACU07799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="357" mass="39697" checksum="6B73A72A89FABB1B" modified="2009-09-22" version="1">MIIQKSTNPRIASFDPDNFSFGNTFIDHMIICEYEDGKWGDVKLVPYGPLPFSPAMMGVNYGQACFEGMKAYKDNDGEVFLFRPEKNFERINKSAARLAMPAITEEMFLGGLKALVDIDRDWIPQGEGNSLYIRPLIFATEEALKARISNKYMFAIVATPAKSYYSEPVSVLISDFYSRAANGGVGSAKAAGNYAASFYPTQLANDLGYEQVIWTDDATHEYFEESGTMNVFVRINDTIYTPPTSEKILDGITRNSFIKLAEKRGIELKVEPVSVKKVIDAQKDGSLKEVWGVGTAVVTSVFRALGYKGEKLELPALSADESFALTLQKDLVNIQTNNAEDPFGWRVQVQKTELENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5X3</accession>
    <name>C6X5X3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="6" type="ordered locus">FIC_01363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806096.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01363"/>
    <dbReference type="EnsemblBacteria" id="ACU07811">
        <property type="protein sequence ID" value="ACU07811"/>
        <property type="gene ID" value="FIC_01363"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01363"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_0_1_10"/>
    <dbReference type="OMA" id="INQPGYD"/>
    <dbReference type="OrthoDB" id="556582at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="367" mass="41196" checksum="1F574ACF7ADDBC5F" modified="2009-09-22" version="1">MENFVVSARKYRPQEFDTVVGQSHITDTLEHAIEENQLAQALLFCGPRGVGKTTCARILARKINERDGSTSEDGFSYNIFELDAASNNGVEEIRDLTDQVRFAPQVGKYKIYIIDEVHMLSSAAFNAFLKTLEEPPAHAIFILATTEKHKIIPTILSRCQIYDFKRITIEDIQNQLRNIADKEGIKYEDDALYMVAQKADGALRDALSIFDRLSTFTQKNITLAKTAEVLNILDYDQYLNIVNLAQENKIPETLSAFNEIVRKGFDAHLFIAGLGNHFRDLMMAQNPGTLHLIEVGEATKARFSEQSKNWNTQQLIDAIEVCNHADINYKNSKNPRLTVEIALMQLSSLTADGVTAKKKVSDFSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X613</accession>
    <name>C6X613_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806136.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01403"/>
    <dbReference type="EnsemblBacteria" id="ACU07851">
        <property type="protein sequence ID" value="ACU07851"/>
        <property type="gene ID" value="FIC_01403"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01403"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093776_3_0_10"/>
    <dbReference type="OMA" id="RVRTRNH"/>
    <dbReference type="OrthoDB" id="1531701at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="200" mass="22694" checksum="D68B8C0463E4D84E" modified="2009-09-22" version="1">MFKTQNPAVVTVSKLISNFFNPLVSLIIYFVYSSYLDFTSTGALVRFLPILLLTVLPIVIWILWNVRKGNYSNLDVSNRQQRKSLYFFIGGAITVYLIYDYVVNTTIDLIMLFLLILLFAMQASNYFIKSSMHMAFNVFVAALFFYKSPFAGLIWLGIAVAVGITRVILQRHTPKEVLMGAAIAASVSFIYLYTAIQTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X635</accession>
    <name>C6X635_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell division protein ftsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FIC_01425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806158.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01425"/>
    <dbReference type="EnsemblBacteria" id="ACU07873">
        <property type="protein sequence ID" value="ACU07873"/>
        <property type="gene ID" value="FIC_01425"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01425"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_9_7_10"/>
    <dbReference type="OMA" id="DMLYTQG"/>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="10">
        <location>
            <begin position="464"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="482"/>
            <end position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU07873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="820" mass="90860" checksum="77DA18DB0B3379E9" modified="2009-09-22" version="1">MEKNTKSTPEKAVTQNKTLSRPRILFGVLFLLISVVLTFSFISYLTNWQADQSQAGTMLDKTVQSSNIFGKAGDWLGNIFIFESIGIAAFAVAFLFLVCGMIILKKTYFKPWKTIGHSLFFICWLPIFMGAVTQGHGVLSGVYGFQIMDFLDSVIGAAGLWLVLFVSIALYFILEFNLNPNNLKAKLNDLNDNTVGRVKAMIPKSAENFEADEELENLTKETGSSVNSFDTPVVPPIPPTPVSLPQKDFPPVEIINDFETIKTPNETSFEDVNNNVKVTSDVNLTGADAINFKVEVAKPVDVLDEHDQRSNDLVEKHGLYDHKLDLANFQMPTLDLLRDYGNEEIAINREELEENKNKIVGLLKNFNVGIAEIKATVGPTVTLYEIVPEAGIRVASIKKLQDDIALNLSALGIRIIAPMPGKGTIGIEVPRKNPSMVSMRSVIASQKFQNTDMDLPVVFGKTISNEIFMADLAKMPHLLMAGATGQGKSVGINAILTSLLYKKHPSELKFVMVDPKKVELSLYSKIERHYLAKLPDGDDAIITDTHKVINTLNSLCMEMDQRYDLLKNAFCKNLKEYNKKFSERKLNPENGHRYLPYIVLVVDEFADLIMTAGKEVELPIARLAQLARAVGIHLIVATQRPSVNVITGMIKANFPARAAFRVISSVDSRTILDSPGADQLIGKGDMLYFNGNEIMRLQCAFVDTPEVEKIAEFIGEQKGYASAFILPEYSSEENTSTVGSFDPNEKDALFEDAARIIVSTQQGSTSMLQRQLKLGYNRAGRIMDQLEASGIVGGFNGAKAREVQISDLNSLEQFLEELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C6X637</accession>
    <name>C6X637_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FIC_01427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806160.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01427"/>
    <dbReference type="EnsemblBacteria" id="ACU07875">
        <property type="protein sequence ID" value="ACU07875"/>
        <property type="gene ID" value="FIC_01427"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01427"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_6_0_10"/>
    <dbReference type="OMA" id="PYSSKQY"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="484" mass="55347" checksum="5D7DB2208B4B46A0" modified="2009-09-22" version="1">MIKKLDGYVIKSFLGPFLFIFSVLFFIFVVNIIWIQLAQFTGKGLSYWEILKLLAYLSVKVVQLVLPLTILLSSIMTFGDFGERYELAAMKAAGISLTRIMMPLFVVSIALSFFLFLFSNNVIPDFQRKAKNMLYNIAATKPALNFSPGQFIQQIPGYSVKFDEITGENGENLTGVFIHKMANSYENQQSIVAEKGKFVQADNRNYLKLVLYNGHIFEENIGNVDYNQRIKQPDQAIKFDTLVSHFNISEIINKALEAEQITDDYSFQNFIELNTTIEKAKKENDNILRNLSDELINQTNGYVGYVDKVVTKVPVTAIPKADTLALEKKQVLYLNAYNKIAGLKELNEGKKPQIKDLHSYNSRIIMYQQRIFAYSMTCLIFFLIGSSLGSIIRKGGLGLPVVIAIMVFIIFYILNLTVENMAWAGEMNPYLASWLPNMVLFPFGAWLTYKALTDSQLFDIEKYKNMLKPVIQLFSKNKEHQRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C6X669</accession>
    <name>C6X669_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806192.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01459"/>
    <dbReference type="EnsemblBacteria" id="ACU07907">
        <property type="protein sequence ID" value="ACU07907"/>
        <property type="gene ID" value="FIC_01459"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01459"/>
    <dbReference type="eggNOG" id="ENOG502Z7RJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123222_0_0_10"/>
    <dbReference type="OMA" id="EAWRDMR"/>
    <dbReference type="OrthoDB" id="1995488at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011630">
        <property type="entry name" value="DUF1599"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07659">
        <property type="entry name" value="DUF1599"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1599" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1599" evidence="1">
        <location>
            <begin position="115"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="188" mass="21722" checksum="D0C1257A261E61CC" modified="2009-09-22" version="1">MEKTSSQFDEAIHVCRDLFSKKLADYGPSFRVLRTPSLTDQIFIKVKSLRNFQTTAVSKVGESEKENFIAIVNYAIIGLIQLEKGFADDFRDENETILQLYDRFANEAKELMLRKNHDYGEAWREMRISSITDLIYQKVLRTKQIEDNAGRTLVSEGIDANYFDMLNYAVFCLIKMHEENGANTSSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6B0</accession>
    <name>C6X6B0_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="13" type="ordered locus">FIC_01501</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806233.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01501"/>
    <dbReference type="EnsemblBacteria" id="ACU07948">
        <property type="protein sequence ID" value="ACU07948"/>
        <property type="gene ID" value="FIC_01501"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01501"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_1_2_10"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="423"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACU07948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="644" mass="71592" checksum="147B66633DC552DD" modified="2009-09-22" version="1">MSQKEYTASSIQALEGMEHVRLRPSMYIGDVGTRGLHHLVYEVVDNSIDEALAGHCDTISVVIHEGESISVKDNGRGIPVDMHEKEQKSALEVVMTKIGAGGKFDKDSYKVSGGLHGVGVSCVNALSTSLVATVNRDGKVYQQKYSEGKALDKVHEIGTTGERGTEVFFQPDATIFQETVYNYDTLAARLRELSFLNKGITITLTDERRPNEDGTFVSEVFHSDGGLREFVEFIDGNRESIMSNVIYMEGDNNDIPVEVAMRYNTSYNENLHSYVNNINTHEGGTHLAGFRRALTRTLKKFADELGIPAKEKVEVTGDDFREGLTAVISVKVMEPQFEGQTKTKLGNSEVSGAVDKIVGEMLTNFLEENPNEAKIIVQKVVLAAKARQAAKKARELVQRKSPMGGSGLPGKLSDCSSKDPAISELFLVEGDSAGGTAKQGRDRHFQAILPLRGKILNVEKSMLHKVYDNEEIKNIYTALGVSVGTEEDSKALNISKLRYHKVVIMTDADIDGSHISTLILTFFFRYMKELIENGYIFIAQPPLYLLKKGQKKIYAYNEKEREEFTLELAPDGKGVEVQRYKGLGEMNPEQLWETTLNPEHRILKQVTIESLADADNVFSMLMGDEVPPRREFIEKNAVYAKIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6H0</accession>
    <name>C6X6H0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin, 2Fe-2S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806293.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01561"/>
    <dbReference type="EnsemblBacteria" id="ACU08008">
        <property type="protein sequence ID" value="ACU08008"/>
        <property type="gene ID" value="FIC_01561"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01561"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_5_1_10"/>
    <dbReference type="OMA" id="GMAMCAS"/>
    <dbReference type="OrthoDB" id="1837979at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="110" mass="11955" checksum="2A78D859EDB39884" modified="2009-09-22" version="1">MQDITLKIIDRNGQTHEVVAPTDMSMNLMEVIRSYELADEGTIGVCGGMAMCASCQVYVVEGSEKLTGMGDEEDAMLSEAFHVQDNSRLGCQIHVTAEIDGLEVEIAPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I5</accession>
    <name>C6X6I5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfate transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_01576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08023">
        <property type="protein sequence ID" value="ACU08023"/>
        <property type="gene ID" value="FIC_01576"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01576"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_7_0_10"/>
    <dbReference type="OMA" id="EAPHDIK"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="417"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="517" mass="55716" checksum="59868DC46ED249B5" modified="2009-09-22" version="1">MWRQNLMKAALNLFDFSQKVNYRTEILAGLTVAMTMIPESLSFAILAGFPPLVGLYGAFIMGIVTAVFGGRPGLISGGAGATVIVLIALMKSHGLEYVFGAVALAGVLQIMVGLLKLGKFVRLVPQPVMFGFVNGLAIVIFMSQFEQFKISTNGQTEWLTGTPFLIMAGLVALTIAIVLILPRFTKKIPASLVAIMVVFAVVMVFYIDTKRVADIASVSGSLPPFHIPNIPFTLETLQVIFPYATIMAAVGLTEGLLTLNLVDEITGTKGNSNRECVAQGGANILNGFFYGMGGCPMIAQTLVNLSAGSRARLSGIVAALTILVIILVGAPVIGQLPMAALTGVMIMVAIGTFEWASLRIFKRMPKSDIFVMIVVTLITVLLHNLALAVLIGVIISALVFAWDNAKRIRARKHVDENGVKHYEIYGPLFFGSVAGFAEKFDVAEDPEEIVIDFRDSRVVDMSAIEALNAVTSRYKKVGKTVRLQHLSADCINLLKNADAIIEVNIAEDPDYMVSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6I8</accession>
    <name>C6X6I8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl-4,4'-diaponeurosporenoate acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the acylation of glycosyl-4,4'-diaponeurosporenoate, i.e. the esterification of glucose at the C6'' position with the carboxyl group of the C(15) fatty acid 12-methyltetradecanoic acid, to yield staphyloxanthin. This is the last step in the biosynthesis of this orange pigment, present in most staphylococci strains.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis; staphyloxanthin biosynthesis; staphyloxanthin from farnesyl diphosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyltransferase CrtO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806311.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01579"/>
    <dbReference type="EnsemblBacteria" id="ACU08026">
        <property type="protein sequence ID" value="ACU08026"/>
        <property type="gene ID" value="FIC_01579"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01579"/>
    <dbReference type="eggNOG" id="ENOG5031308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712114_0_0_10"/>
    <dbReference type="OMA" id="ISWIVGM"/>
    <dbReference type="OrthoDB" id="1964756at2"/>
    <dbReference type="UniPathway" id="UPA00029">
        <property type="reaction ID" value="UER00560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044021">
        <property type="entry name" value="CrtO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18927">
        <property type="entry name" value="CrtO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="161" mass="18409" checksum="AB1C8C200F3B5FC4" modified="2009-09-22" version="1">MIAVYISLSISIVFISFIVGMVITAVVQKTDFYKKTLSNLNFLESEKLNTLIGVGAVRWLVRNTFFKIFNPNIKIPRGANSADLRRIRDEMTKAEIGHLSAFLFVTLFMIMKIFQQEYTFAVVILAVNVLMNLCPSLLQQQNKRRLDGVISRMTKILRSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZN4</accession>
    <name>C6WZN4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781716.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00093"/>
    <dbReference type="EnsemblBacteria" id="ACU06569">
        <property type="protein sequence ID" value="ACU06569"/>
        <property type="gene ID" value="FIC_00093"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00093"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_7_10"/>
    <dbReference type="OMA" id="KIHRFGF"/>
    <dbReference type="OrthoDB" id="1650683at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="252" mass="29120" checksum="7CFBF4B66EA621BC" modified="2009-09-22" version="1">MENITIAGLNLDIVWKDKEANFKQIEALLKNTEADLIILPEMFSTGFYMKPEEIADRNEETLNWMKNFAKRRRIAVCGSVSVAEEGSFYNRFYFVSPDGQFQQYDKRHLFSFSGEHKTYAAGQERIIVRFKGWRILLQVCYDLRFPVFARNNADYDAILYVANWPEARIDAWTTLLKARAIENQSYVFGLNRIGTDGNNLSYPESSYCFGPAGEVVSEIAGQIVAAEFNAEKLTAFREKFQFLNDRDSFRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZS8</accession>
    <name>C6WZS8_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00138"/>
    <dbReference type="EnsemblBacteria" id="ACU06613">
        <property type="protein sequence ID" value="ACU06613"/>
        <property type="gene ID" value="FIC_00138"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00138"/>
    <dbReference type="eggNOG" id="ENOG50331DF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131426_0_0_10"/>
    <dbReference type="OMA" id="DIRMNDV"/>
    <dbReference type="OrthoDB" id="1871038at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="174" mass="19721" checksum="7CCC351550DA0942" modified="2009-09-22" version="1">MNRKYIFVPMKNVFFLLVILGFGLFSCRNDDEVVQDIDQVVQIYIDSAGQDMLNTNIEGGYTDIRMNDVNGFTDSAPVTFSFKKDKDTLNYIEYIAGARRIGVDSSAAFKTYESTVALILNKRTSDSTNVVINDTIRLEYNATPELFQISKVWYNNVLKFTKVEGAPNVVKVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6WZU1</accession>
    <name>C6WZU1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012781773.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00151"/>
    <dbReference type="EnsemblBacteria" id="ACU06626">
        <property type="protein sequence ID" value="ACU06626"/>
        <property type="gene ID" value="FIC_00151"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00151"/>
    <dbReference type="eggNOG" id="ENOG5032YAH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2261697_0_0_10"/>
    <dbReference type="OMA" id="INDLMYN"/>
    <dbReference type="OrthoDB" id="1783960at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU06626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="111" mass="12275" checksum="299849A7B867693D" modified="2009-09-22" version="1">MNTNTQTIQGVLSIAALLCLVVGFFDLFSPEINDLMYNKLFYILIGASFYFQAPTLTNKNLLYPMYAAAALCIIGAFLPADSQFAVIKTIGLFAGVILSIFNRPRAVRRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0F7</accession>
    <name>C6X0F7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_00376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU06843">
        <property type="protein sequence ID" value="ACU06843"/>
        <property type="gene ID" value="FIC_00376"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00376"/>
    <dbReference type="HOGENOM" id="CLU_2716508_0_0_10"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU06843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="72" mass="8343" checksum="99A0BE5884C12040" modified="2009-09-22" version="1">MMRGLEFFELLLFLFLTLINIHSKMPGGIAGSVSAFFGDSLMKRVLDDRMLHAVECTLDNPLFHHDWNKLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0H4</accession>
    <name>C6X0H4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00393"/>
    <dbReference type="EnsemblBacteria" id="ACU06860">
        <property type="protein sequence ID" value="ACU06860"/>
        <property type="gene ID" value="FIC_00393"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00393"/>
    <dbReference type="eggNOG" id="ENOG502ZCKV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1213058_0_0_10"/>
    <dbReference type="OrthoDB" id="1241965at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973442" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="230" mass="24823" checksum="8C81AA734B85D10B" modified="2009-09-22" version="1">MKKIMISGILLIGGMVSAQTAITFNGCHNLFEDQNFLFSNTGTDSFSKRIYITTPVDGDQSCGGIGTCEFKIQWNNALTRWEFLADSGNGDFVDPFLIYYNATGNSAATNPPGNTFGTWVENTDVTEGACGGNLSAANSVFTGDLHSSSLATGSAEHRKVQLFPNPVTDFIGISGVESAQSVQIFNAAGQLVQTEKFSERMNVSTLKPGVYILRIVSPQSDFTELKFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0P2</accession>
    <name>C6X0P2_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU06928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782075.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00466"/>
    <dbReference type="EnsemblBacteria" id="ACU06928">
        <property type="protein sequence ID" value="ACU06928"/>
        <property type="gene ID" value="FIC_00466"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00466"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022137_0_0_10"/>
    <dbReference type="OMA" id="FHVFNAS"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="55"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU06928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="266" mass="30110" checksum="F1041A380BD7E2F9" modified="2009-09-22" version="1">MAKKNIFTDAFGNLYFLKRLIIIILGVVSYRRFNGFNKLKITGTENLQDLPGSNVLFVSNHQTYFADVAAMYHAFCAVNNGYLNTIKNPVYLLNPKVDFYYVAAEETMNKGLMTKIFKLAGAVTVKRTWRAEGSNVNRMVDLTEVENIMKALDNGWVITFPQGTTSAFAQGRKGTAKLVKNQRPIVIPIKINGFRRAFDKKGLRVKVTGVKPTMEFKAPLDIDYDKDDAQCILNKIMVAIEQTEDFNLLHDYDLELKAQKSEETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0U7</accession>
    <name>C6X0U7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806345.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01614"/>
    <dbReference type="EnsemblBacteria" id="ACU08060">
        <property type="protein sequence ID" value="ACU08060"/>
        <property type="gene ID" value="FIC_01614"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01614"/>
    <dbReference type="eggNOG" id="ENOG503355B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2449943_0_0_10"/>
    <dbReference type="OMA" id="NDFRMRK"/>
    <dbReference type="OrthoDB" id="1908568at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU08060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="96" mass="11640" checksum="455935F08B1D46E0" modified="2009-09-22" version="1">MKKKREFQSSELVKSFARIYGFEDKLLAFEVKDFLNEYLNDELFREIEAVNLEQKILKIKIKSPMLKNDFRMRKSFFLKKFQEKFGAENFNDLQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>C6X0Z3</accession>
    <name>C6X0Z3_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806391.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01662"/>
    <dbReference type="EnsemblBacteria" id="ACU08106">
        <property type="protein sequence ID" value="ACU08106"/>
        <property type="gene ID" value="FIC_01662"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01662"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_6_2_10"/>
    <dbReference type="OMA" id="MERETYD"/>
    <dbReference type="OrthoDB" id="1735902at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="3">
        <location>
            <begin position="31"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="164" mass="19477" checksum="ED229B166F5DA8F4" modified="2009-09-22" version="1">MTNEFVLEAITREFPDSVISHSEPYDFLTLEIKKEDIKKVIHYLRDSSLEINFLTDICGIHYPSDPEKELGVIYHLHNMMTNFRIRLKCFMPRENAEVDTMTDLYAGANWMERETFEFYGVKFKGHPDLRVILNMEDIGYHPLLKEYRLEDGTRTDKDDKMFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>C6X139</accession>
    <name>C6X139_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806437.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01709"/>
    <dbReference type="EnsemblBacteria" id="ACU08152">
        <property type="protein sequence ID" value="ACU08152"/>
        <property type="gene ID" value="FIC_01709"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01709"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_8_10"/>
    <dbReference type="OMA" id="YVKQIYR"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="216" mass="24091" checksum="3D8D12426FE832F6" modified="2009-09-22" version="1">MTEGKIIFLLGDDHQIVRQGLSFVINDLFPNSEIKHAPTLNDVLLKAQVGPIDIAVLDAQFPDGNSISIIKKLRELQPAVKILIFTSSEEEHFALRFLREGANGFLSKLSEESEIETALAEMVNNGNYLPPLTRQMLAESAVNPENTDPLSKLTDRELEVADLLAQGLGNLEVANHLDLRQNTVSTFKKRIFSKLNVENMVDFIELMRIIRPSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E6</accession>
    <name>C6X1E6_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_01816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806544.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01816"/>
    <dbReference type="EnsemblBacteria" id="ACU08259">
        <property type="protein sequence ID" value="ACU08259"/>
        <property type="gene ID" value="FIC_01816"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01816"/>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053322_0_0_10"/>
    <dbReference type="OMA" id="KVGEYQR"/>
    <dbReference type="OrthoDB" id="1384440at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="324" mass="37637" checksum="1F555586C5E679AE" modified="2009-09-22" version="1">MGIFDKRIGYKPFEYPEIMQFVEAINKSFWVHSEVDFTADVQDFQSQLEPHEKNAVKNALLAIAQIEVSVKTFWGNLYNHLPKPELNGLGSTFAECEFRHSEAYSRLLEVLGYNDAFNHVVEIPAIKKRIDFLSNVLKHANSTTPKEYVSSLLLFSILIENVSLFSQFAIILSFTRFKGYMKNVSNIIAWTSVDEQIHANAGIYLINKIREEQPDLLTDSDIEDIYTLVDHSIELEAEILDWIFEMGEIDNVSKENLLNFMKYRVDDSLKKIGMQTRYNVSGDEYRPMVWFEEEVFANSMDDFFAKRPVDYTKHDKSITENDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1E9</accession>
    <name>C6X1E9_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FIC_01819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01819"/>
    <dbReference type="EnsemblBacteria" id="ACU08262">
        <property type="protein sequence ID" value="ACU08262"/>
        <property type="gene ID" value="FIC_01819"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01819"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_10"/>
    <dbReference type="OMA" id="IQKYPAT"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="321"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="422" mass="46649" checksum="1696F1E09C2D3A89" modified="2009-09-22" version="1">MNIIFKIDTWQEIYHSLRNNKLRTFLTMIGVGWGMFLFVVLLGAAKGMENGFDKIFAGFATNSIFLWAQNTTIPYEGFPKGRKMDLHLSDIEMLPRKVGEIDYISPQNSRGNFGSPGESFSRNAKKATYTLTGDYPIGNKISQKKLIFGRYLNDADVTGSKNVIVIGEEIYKNFFDAKKNENPIGKSVNVKGIFFSVIGVFRAQKGGGPENDQSAFIPLSTFTKMYNDGDKVGFFAIVSKPNADLAKVEDQVKLELKDKYNVSPDDTNAFGSFNLGKEFKKLTGFLTGMQLLTIVVGSLTILAGVIAISNILLITVKERTKEIGIRRALGAKPAEVRNQILLESVVITLISGLLGFIIGIFVLMIADMLTKGQDEFPFYNPTVNYGEVLAAMAIMVFLGLVIGMIPAQRAVRIRPIEALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1G7</accession>
    <name>C6X1G7_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806565.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01837"/>
    <dbReference type="EnsemblBacteria" id="ACU08280">
        <property type="protein sequence ID" value="ACU08280"/>
        <property type="gene ID" value="FIC_01837"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01837"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_3_0_10"/>
    <dbReference type="OMA" id="RYSGPDY"/>
    <dbReference type="OrthoDB" id="1227369at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU08280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="332" mass="36464" checksum="53127F6BC8E9D397" modified="2009-09-22" version="1">MTKVLAKNHTETTQEHVEERNGGLPFNTRFFDGININRSAVERRVNTLPGRRSVKKEFQAAWLLKAISMIDLTTLAGDDTRGNVIRLCEKAKNPVRQDILMKLGMEDANLTTGAVCVYHSLIPFAAEALQGSGIPIAAVSTGFPAGKNAIEEKIAEIKRSVAAGATEIDIVISRDLVLESKWKELYDEIKLCRQACGDAHMKTILATGEIPTFTKIAKASWVAMLAGSDFIKTSTGKESVNATLAVSLVMIRCIRDYYELTGVKVGYKPAGGIQKAKQALDYLILIKEELGNEWLTPELFRFGASSLLGDIERQLEHYVTGSYSAGFRHPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1M5</accession>
    <name>C6X1M5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="7">FBPase class 1</shortName>
            <ecNumber evidence="7">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fbp</name>
        <name evidence="11" type="ordered locus">FIC_01896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3519-10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806623.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01896"/>
    <dbReference type="EnsemblBacteria" id="ACU08338">
        <property type="protein sequence ID" value="ACU08338"/>
        <property type="gene ID" value="FIC_01896"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01896"/>
    <dbReference type="eggNOG" id="COG0158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_2_2_10"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="945770at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBPase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="FBPase_C" evidence="10">
        <location>
            <begin position="205"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACU08338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="338" mass="37617" checksum="37CD4F1C05C5C033" modified="2009-09-22" version="1">MPEQNFQTLGEFIIDKQEDFQYSTGEFSRLLSAIRLASKVVNREVNKAGIANIIGQSGNENIQGEEQQKLDVLANEIFIEALSQREVVCGIASEESDDFIDVRASSNAHLSKYVVLIDPLDGSSNIDVNVSVGTIFSIYRRVTEPGTPVALEDFLQKGVNQAAAGYVVYGSSTMIVYTTGNGVNGFTLDPSLGTYYLSHPCMKFPETGKIYSINEGNYIKFPQGVKNYIKYCQREEDDRPYTSRYIGSLVSDFHRNMIKGGIYIYPSTSQSPNGKLRLLYECNPMAFLAEQAGGKCTDGFQRILEIQPTELHQRVPFFCGSIKMVEKAEEFMQAAADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1R1</accession>
    <name>C6X1R1_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase, family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806659.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01932"/>
    <dbReference type="EnsemblBacteria" id="ACU08374">
        <property type="protein sequence ID" value="ACU08374"/>
        <property type="gene ID" value="FIC_01932"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01932"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_3_0_10"/>
    <dbReference type="OMA" id="NIFEAHR"/>
    <dbReference type="OrthoDB" id="728505at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU08374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="336" mass="37986" checksum="437ECDF6033ADD4C" modified="2009-09-22" version="1">MEYIIVTLLLFILMLAYFKIALKYKIIDKPNHRSAHSEVTIRGGGVVFPVAFLLFLLTIAGVGFLSLPASDINFENHNFLMFGIGLLLICIISFIDDVTDLSSKIRLAFHVVVVTFLMLFLDILAIQPMWLIPVLYIIIIGILNAYNFMDGINGITGLYTLAVLLSLWYINTYIIDFTADGFIIYPLLATIVFLFFNFRTKAKCFMGDIGSMGIAFWVIALLGLLILKTGELKWILFLSVYGVEVIATLLERLKLKENIFEAHRRHLYQLFANDLKISHLTVSAVYAVCQLLINAFVIFSDLPDAVIFPVVLMPLVILYFYTKYAVKKAIPKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X1Y8</accession>
    <name>C6X1Y8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ordered locus">FIC_02009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806735.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02009"/>
    <dbReference type="EnsemblBacteria" id="ACU08451">
        <property type="protein sequence ID" value="ACU08451"/>
        <property type="gene ID" value="FIC_02009"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02009"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_10"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="87"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACU08451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="183" mass="20499" checksum="0420107F64ACB38C" modified="2009-09-22" version="1">MEYTVRPKKLYKEQIIPAMMEEFGYKSVMQVPKLEKIVISQGLGAATADKKIVDYAIEELTAITGQKAVGTLSKKDEAAFKLRKGMPVGARVTLRANQMYEFLDRLTSSALPRIRDFNGIKADGFDGRGNYNLGITEQIIFPEIVIDKVKKIQGMDITFVTTAKTDKEAKSLLTHFGMPFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C6X208</accession>
    <name>C6X208_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ordered locus">FIC_02029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806755.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02029"/>
    <dbReference type="EnsemblBacteria" id="ACU08471">
        <property type="protein sequence ID" value="ACU08471"/>
        <property type="gene ID" value="FIC_02029"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02029"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_10"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACU08471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="158" mass="18120" checksum="CFE3177B6F2C282E" modified="2009-09-22" version="1">MRKTKAKKRPLLPDPKFNDQLVTRFVNNLMMDGKKSIAFKIFYDALDLVESRKGETEKTALEIWKDALTNVMPHVEVRSRRIGGANFQIPMPIRADRKISMAMKWLIKYSTARNDKSMAQKLAAEVIAAAKEEGAAYKKKTDTHRMAEANKAFSHFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2E5</accession>
    <name>C6X2E5_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ordered locus">FIC_02172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02172"/>
    <dbReference type="EnsemblBacteria" id="ACU08608">
        <property type="protein sequence ID" value="ACU08608"/>
        <property type="gene ID" value="FIC_02172"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02172"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_3_1_10"/>
    <dbReference type="OMA" id="FEPNLHT"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="95" mass="10936" checksum="838DF71104058A35" modified="2009-09-22" version="1">MHSQIFSSKKEHRDMSRICQITGKRAMVGNNVSHANNKTKRRFEINLLEKKFYLPEQEKSVTLKVSAHGLRIINKVGIEEAIEAAIRNGFIKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C6X2H8</accession>
    <name>C6X2H8_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IgGFc_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_02206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02206"/>
    <dbReference type="EnsemblBacteria" id="ACU08641">
        <property type="protein sequence ID" value="ACU08641"/>
        <property type="gene ID" value="FIC_02206"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02206"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277527_0_0_10"/>
    <dbReference type="OMA" id="QFSKTHY"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668773" description="IgGFc_binding domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="IgGFc_binding" evidence="2">
        <location>
            <begin position="130"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU08641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1384" mass="149253" checksum="D33288735B52BC7D" modified="2009-09-22" version="1">MPMKKLLPFLFIFIYSAFSAQLDREHWFAPMYDGQSNTGPSQFLHLSTNETVPFNVNVYSNNVVVYQRTISKGSPAIISIARHYIITTSTSDLHRVGTKGLYVKADKPCFANLRFKVTNHAEIITSKGTAGIGKKFYTVMAPNLQGSSNLGASASFLATEDNTLVTVNNFKKVLTFNSYGSAASFTFTLNKGQSYIIDGRAANMNNRDGLIGATVTADKPISMSNGNFNGQYATSDTSEGSDILMDQSVPVDKLGDEFAIVKGYGEIGNNMEGAVVVATENNTAIYLNDSATPFATLAAAGDFYVINEINYVNRGNDHYNLRIKTDKNVYVYQLLGGVKDGDAFLATGGMNYIPPLNCYLPKRIDEISNINKIALSDPTEYFLTKLNIITAKGAVVKVNGVVPDPEFGPFETSNIPTDQEWVTYSIPGVTGNITIESDKAVTAGIASGNAAFGYGGYFAGFSAIPLILKTEGDCLPGVKLEVTAGFDSYEWLIKNTDGTYSPAPGVNNTYTYEPPQAGIYAVRVKQGTCEEIQTQDFKFYNCTTYTNTDYDSCGTETITPTFSLSTQAVNPSTVTLVTPPTKGTVTIAASGVITYTANPGASGLDTFKYSFCGTGAIPDCETAQASIFMIEKRDDAILQECSTNGIAVYNLTLANVTSDNTLTKSYFTTQNGAQNNVAAEQISDFTSYSSGDTSVYVRLVNSKGCISVAKIQLKAKLAPEVMAELYTKLHCDEDVDGKIDGIYKVDLSTVTPIVLVQASDFTVRYYNDGPSATAGLNNNITGILEFAANRSVWIRVDAPNGCPTVIKEIQLKTGTPTPLISQIVSELVCDLDLDNSESVNLQDYIPLFTAGTATATYHTTLTDAQNNQNAIGANQNVTANSSYFYRITVAGSCASIGTLNLQLSAGTPSTTLPASVTICEGATTTLNVGSGFTAISWSTGASTPTIIVGAGSYWVDLTNASGCVYRQNVSVLDAPKPNWNVAAYNAVHCDEDFDGIIKIDLLTVTPVILPNHIAFTVEYFADPAYTTPLPDNWSYSADTTVYVRATSAFCPTTFAQIDFKTGTSLPLTMLTATTTVCDNDLSGSESVNLADYINLFTTATGVSVKYFDHLTDAQSNSPGSEINATQTIIGNKTFYYRFSKTDFCDVIGTLNITFKQPKKSTVLADQQICPEATTTLNAGPGFDGYLWSTGETTRSITVPVGEYWVELTSNGCVYRQTVSVTAVALPEIVSIDIKGSTVTITATGGNSPYQYAIDNHNYQSSNVFTNVVGGDHTVYVISADNCKAVSSDFNVIQRFNVITPNGDGKNDILDYSGLLKKAEPYLVIFDRRGQTVFTGSSTNRFTWDGKISGRALESGSYWYVMKWIEPGFTSVTEYSGWILVKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C6X324</accession>
    <name>C6X324_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AcrB/AcrD/AcrF family membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_02404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015807121.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_02404"/>
    <dbReference type="EnsemblBacteria" id="ACU08837">
        <property type="protein sequence ID" value="ACU08837"/>
        <property type="gene ID" value="FIC_02404"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_02404"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OMA" id="LMYMSSS"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="928"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="973"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU08837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114060" checksum="3A6E7BDAD156E46F" modified="2009-09-22" version="1">MVKQFINRPVAASVVSILIVILGVLGLRSLAVTQYPDIAPPTVSISANYTGASAETVMNSVIIPIEEQVNGVEGMDYITSSASNSGSANIQVFFKQGVNPDIAAVEVQNKVQRAIPLLPGDVTRSGVTVQKQRTSALMFLSFYTDNKDLDEVWLQNYLNINVIPELKRVNGVGDAQAFGGKNFSMRVWLDPAKMASYGLEPSDVTASINEQSREAAAGQLGQNSGNAFEYVITYKGKFDEAQDYGDIILKSLGNGQFLKLKDVAEIKLDAQSYSSIGENNGRRSVSMGIFQTPGSNAQEIIKDIKVFLEENQKTMPEGVGYTINFDTNDFLEASIGKVVTTLLEAFVLVFLVVYIFLQDLRSTLIPAIAVPVSIVGTFFFLNLFGYSLNLLTLFALVLAIGIVVDDAIVVVEAVHAKMENGFTDAKKATVSAMDEITGAIISITLVMAAVFIPVTFITGPTGVFYQQFGVTLIVAILISAVNALTLSPMLCALFLKPNAAHHKEYAQMNWLQKFFYKFNAAFKSATDRYGRFFVFLLRHKWATLVIFAVGGLFFWWSNATMPSGFVPKEDRGIIFTDVALPPGASMERTYNVLKDLQDEARKIPGVANVTFTASRGFMSGSGSNAGQAFIRLKSFDDRAKDDEQSVEAITKRLFGLAGKYPDAKIVFFSPPSIPGFGTSDGFSAVLLDKSGGSLRQLDDAARNYLGALMQRPEIQFAQTSFNTNYPQYEMVIDVPRAKETGVSVSDILSTMQGYVGGVYAADFTKYGKQFRVMVQAFPDARNEPSDLSSIFVKTASGQMAPISQFVTMEKTFGPKSVERYNLFTSVSLSGSNNPGFSTGDAIRAVQEVAAEHLPADYVVEFTGLSKEELSSGTQTAVIFMLSLVFVYFILAAQYESFLLPLAVIISLPLGVFGAYFGQKIAGLENNIYFQIALIMLVGLLAKNAILIVEFAVQRRQHGESLSMAAINAAKARLRPILMTSFAFIFGMLPLVFASGIGSVGNRSIGTGAAAGLLIGTFFGLLAIPVLFVIFQWLQEKVKPLKKSEIHLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>C6X480</accession>
    <name>C6X480_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FIC_00763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3519-10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782364.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00763"/>
    <dbReference type="EnsemblBacteria" id="ACU07218">
        <property type="protein sequence ID" value="ACU07218"/>
        <property type="gene ID" value="FIC_00763"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00763"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_10"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="4"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACU07218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="391" mass="43128" checksum="E993D54DEBC44603" modified="2009-09-22" version="1">MDKIYLDNAATTPLSEEVIDAMVQVMRVNYGNPSSTHSFGQDAKILIENVRRDVAEYLHVSPSEIIFTSCGTESNNMIIKSCVDHLGIERIISSPMEHKCVAETVMDMKKRRGVEVEFLRPDRNGDFDLKVLEDLLKSSDKKTLVSLMHANNEIGNLLDIKKVAQICKEYNALFHSDTVQTIAHMELDFSDIPLDFASCSAHKFHGPKGSGFAFIRKSSGLKGIITGGPQERTLRAGTENVCGIVGLGKALELSVENMDDYSSHIKDVKKYAIERLSAEIDGVKFNGRSAEEDISLYTVLSVLLPFKDPMIGLKLDIKGIAISQGSACSSGASKPSMVMMMLLDEEEMQGSTPLRISFSHLTTKAEIDTLIDALKEISESFKIESTNTSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4I4</accession>
    <name>C6X4I4_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FIC_00869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012782468.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00869"/>
    <dbReference type="EnsemblBacteria" id="ACU07322">
        <property type="protein sequence ID" value="ACU07322"/>
        <property type="gene ID" value="FIC_00869"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00869"/>
    <dbReference type="eggNOG" id="ENOG5033IR0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150510_0_0_10"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002973459" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="168"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACU07322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="241" mass="27301" checksum="1D822B93B45E1ED6" modified="2009-09-22" version="1">MKKLYIFLLIFFSSFALSQPYSYLLQNTDWTIMKINWYGTDYYPPEPFKESGKVIFNGANMPFESRFFNYIMGGVTFGPNNANYFHLQNLFRSYVDIWDPGLEQVRQFDEKVISFYYPSQPSDLFYFVYSEASSGKTLVVTNPAGHKLYYSNLLLSSSGSVLNKRITMYPNPAKDAFFVNSSGKIAQILNVEIFDAAGNLVASQKIATTDAVNTQNIPNGLYIVKVSGSGVHYSGKLVIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C6X4R0</accession>
    <name>C6X4R0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_00947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_00947"/>
    <dbReference type="EnsemblBacteria" id="ACU07398">
        <property type="protein sequence ID" value="ACU07398"/>
        <property type="gene ID" value="FIC_00947"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_00947"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_6_10"/>
    <dbReference type="OMA" id="PKMGMEA"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="161" mass="18303" checksum="F6487A396BEA0516" modified="2009-09-22" version="1">MYIFENKILQIMKTTTTDKVDNIDLILKSTWLSVSKMYSDLAQDHDATAVQALTLLKIDPKEGTRSTNLGPKMAIEPTSLTRIIKLLEDNGYIYKEKTANDKREVIIKLTDKGLNSRNLSKEVVVNFNKKVTEKISGEKLEVFKEVMADILKIANELNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>C6X516</accession>
    <name>C6X516_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serC</name>
        <name evidence="8" type="ordered locus">FIC_01054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805789.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01054"/>
    <dbReference type="EnsemblBacteria" id="ACU07504">
        <property type="protein sequence ID" value="ACU07504"/>
        <property type="gene ID" value="FIC_01054"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01054"/>
    <dbReference type="eggNOG" id="COG1932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034866_0_2_10"/>
    <dbReference type="OMA" id="GYRASMY"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="5"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACU07504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="354" mass="39010" checksum="DBAD798E35C056F0" modified="2009-09-22" version="1">MNKVHNFSAGPCILPQEVFEKSAEAILNFNGIGLSLLEISHRSKDFVAVMDEARAIVKRLMKLGDDYEVLYLGGGASLQFLMVPFNLMKADGGKAAYLDTGVWAAGAIKEAKIVGNVEIVGSSKADNYSYIPKDYTVGSEYDYFHCTSNNTIYGTQMKTFPKVDTLMVCDMSSDIFSREIDFSQFDLIYAGAQKNMGPAGVTLVVVKKSILGKTGRTIPSYLNYQLHIDKESMFNTPPVFPVYASLLTLQHLEKNGGIAAAEARNIAKAKLLYDEIDRNPNFETFCKAEDRSLMNPSFKLTDESKKEAFDAAWKAAGLSGLNGHRSLGGYRASMYNAMPIESVQILVDVMQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C6X596</accession>
    <name>C6X596_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805869.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01134"/>
    <dbReference type="EnsemblBacteria" id="ACU07584">
        <property type="protein sequence ID" value="ACU07584"/>
        <property type="gene ID" value="FIC_01134"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01134"/>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487247_0_0_10"/>
    <dbReference type="OrthoDB" id="86688at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002970693" evidence="1">
        <location>
            <begin position="24"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="186"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="486"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="559" mass="61238" checksum="5E522C9FAF4CA9CF" modified="2009-09-22" version="1">MKRIFTLLSALPALLLVSGSLNAQQTIYTESFSYPPGAVAPGWSFEGQHAPNWKVNNSQISGGTAPEFYMGYGMQEGLTRVVSPAVTITGYKHLALSYNQYLINFAADAGETVGMDVTFDGGQTWQTLWEKPLGLLNIPQDRFTYFITAPEGATQMQYAFRFIGNHFFINGWAIDDVKIEEAVDKDLVAGNITGNTAINAGQIATFVVDVTNGGKSSQNNYTVKLKSGDGAELAAVSGAPLNFGEKSQVSLTWTPQPGDIPGKTLYAVVESADDINPDNNASRDLAVIVLKENTTNVQIGTESYALQHSIPFNFYTLYSLSQTLYTAQQIGNSGSKMTGIQYVSHFDEDNNDIPVQIYLAETDQEDLSSEWLNPASFTKVYDGTLDFKKGLNNLYIPLQTEFNYTGKNLVIYTNKTHPQQVLWSTFMSTYVDGPVVSRYSERDDAPFDAMTPPEGYPAFYTPNVTLFFEDGSMSVIDSGANTSVSVYPNPAKDFLKIKTDGNERALEIRMFSAAGQQVLHKKLDKGAADVDIRGLRSGYYLAQVTTSAGTVTRKVLVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5C7</accession>
    <name>C6X5C7_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805900.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01165"/>
    <dbReference type="EnsemblBacteria" id="ACU07615">
        <property type="protein sequence ID" value="ACU07615"/>
        <property type="gene ID" value="FIC_01165"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01165"/>
    <dbReference type="eggNOG" id="ENOG5033NAC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209802_0_0_10"/>
    <dbReference type="OMA" id="IFKTGVW"/>
    <dbReference type="OrthoDB" id="2093690at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="54" mass="5843" checksum="A05A7FD6F3AE5F35" modified="2009-09-22" version="1">MKKFTFLSLVTLALMTLTGCDAIGAIFEAGVWTGVIAIAAVVGLILWLFTRNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5F4</accession>
    <name>C6X5F4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein containing DUF187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FIC_01194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805927.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01194"/>
    <dbReference type="EnsemblBacteria" id="ACU07642">
        <property type="protein sequence ID" value="ACU07642"/>
        <property type="gene ID" value="FIC_01194"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01194"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019247_2_1_10"/>
    <dbReference type="OMA" id="APQLYWR"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002972336" evidence="2">
        <location>
            <begin position="26"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="64"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACU07642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="522" mass="59772" checksum="10D954EEA524AEF9" modified="2009-09-22" version="1">MNIRHSKLILLLASAVFLNSCSTQKQVKNPVKAEKPQSSKPVTIRPSAVEDEVIKLNLPEVKREFRGVWIATVANINWPSRNNLSTQQQQEEAIRILDLLRDANFNAVIFQARPSADAMYKSDLEPWSYFLTGETGKAPSPFYDPLEFWISESHKRGMELHVWLNPYRAHHTTGGPVTSQSMVKKMPEQIVKLRNGMYWMDPSADETQDLASKVITDLVKRYDIDAIHIDDYFYPYRDYNSGKDFPDNKTWNTYVKSGGNLSRADWRRGNVNKFIKRIHDEIKAEKSHVRFGISPFGIWKPGFPEGIKGSSQYDELYADAKLWLNEGWLDYFAPQLYWKNDGPQSFPSLLKWWESENKLKRHLWPGLNTVGLRDVSDRPREIVSQIDITRNIHNSMAGTIHYSVDGLAKSSAMYTAVKDAYRTKALPPRTPWIKAAPPAKPILMVQNSGSSARIHWQSADSDQVFQWILYSKYGDVWETEILNKTTTATLLPLTKNGKKLSTVAVKSVDRLSNESDYDAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5M5</accession>
    <name>C6X5M5_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FIC_01265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01265"/>
    <dbReference type="EnsemblBacteria" id="ACU07713">
        <property type="protein sequence ID" value="ACU07713"/>
        <property type="gene ID" value="FIC_01265"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01265"/>
    <dbReference type="eggNOG" id="COG2841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165482_0_1_10"/>
    <dbReference type="OMA" id="DEYHEVN"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007420">
        <property type="entry name" value="DUF465"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038444">
        <property type="entry name" value="DUF465_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04325">
        <property type="entry name" value="DUF465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACU07713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="108" mass="13058" checksum="EDF947224E71ECE2" modified="2009-09-22" version="1">MTILITWLREIFFNFNVLKSLKYKAMENHNLTNEFPEYESKIKALKLNDDGFKKMYVNYEEVNALIQHYEEGEQNHTTDEHLTELRKKRVHLKDVLYSYLRQTEVTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5P0</accession>
    <name>C6X5P0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806013.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01280"/>
    <dbReference type="EnsemblBacteria" id="ACU07728">
        <property type="protein sequence ID" value="ACU07728"/>
        <property type="gene ID" value="FIC_01280"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01280"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_10"/>
    <dbReference type="OMA" id="YHEKTIR"/>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="242" mass="27069" checksum="978D5EDD4061AD77" modified="2009-09-22" version="1">MLTAHKIKILQSLDKKKFRQKYNLFLVEGNKTIKEIPASRYVINEVFSVNPAELKLKNVEAQAVSESELRRISFLQNPKDSVAVCQLLPTEILPEPPVQLILDGIQDPGNLGTIIRLADWFGIGQIICSEDTVDIYNPKVIQASMGSFLRVNVFYADIKEYLTDSPIATIGTDMEGENLYNFKFPERFNLVFGNEGNGIRPEIDNLLTDKITIPRFGKSKSTESLNVSMATGIILGQIFSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C6X5Q4</accession>
    <name>C6X5Q4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
            <ecNumber evidence="7">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FIC_01294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3519-10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="7"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806027.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01294"/>
    <dbReference type="EnsemblBacteria" id="ACU07742">
        <property type="protein sequence ID" value="ACU07742"/>
        <property type="gene ID" value="FIC_01294"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01294"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_4_1_10"/>
    <dbReference type="OMA" id="NNHAPIV"/>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACU07742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="93" mass="10061" checksum="37ED2F53CF70ED42" modified="2009-09-22" version="1">MNIKILTPEFVAFEGEVSSVLLPGKDGDFHIKKDHAAIVASLTGGKVKVYTNEIAENYAKNFTKENTSEGVYSIVVKSGVVEFSNNKGIILAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C6X661</accession>
    <name>C6X661_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative proton-dependent peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FIC_01451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3519-10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806184.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01451"/>
    <dbReference type="EnsemblBacteria" id="ACU07899">
        <property type="protein sequence ID" value="ACU07899"/>
        <property type="gene ID" value="FIC_01451"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01451"/>
    <dbReference type="eggNOG" id="COG3104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_0_2_10"/>
    <dbReference type="OMA" id="GAWYISS"/>
    <dbReference type="OrthoDB" id="470322at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACU07899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="554" mass="61151" checksum="A28BDB7EA021F951" modified="2009-09-22" version="1">MATSTSKHPKGLPYLFFTEMWERFGYYLILGIFVLYMIDPAETGGLAFNDKNADDIFGTFIALTYLTPFLGGFLADRVLGYIKAIYIGGALMGLGYIGLGVFQDIPMFYASMGLIILGNGFFKPSISTLLGNLYEEEPYRLNKDAGYNIFYMGINLGAFACNIIAAFMRNKFGWGEAFITAGVGMFLGLIIFSIGRKHILKANIIKPAQEGDTKISDVLIKVFLPAIVAGLIGWMIPGNVFGSDSTDAFIFACLPVVYFYVMLYVKANAEDKRPIGALLAIFAVSLMFWAVFKQNGTALTRWANYYTDRSVPAALEKPLEAIYLVDSKDYTSKEVNVYDDQYQAQKDEAGNAIKENGKDIYFRNELPEKKAAMDANPEGKVYLYNTELFQSVNPFWVIVLTPVVVGFFMYLRRKGKEPSTPSKIVLGLFISALSCLVMVGAVYAGQNGLVKVSALWLIAAYGVITIGELCLSPMGLSLVSKLSPPRITALMMGGFFLSTSIGNKLSGVLASFWYDYENKANFFIVNFGLLLLATLLGLSILKRLNVIMKEKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>C6X675</accession>
    <name>C6X675_FLAB3</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="14" type="ordered locus">FIC_01465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3519-10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806198.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01465"/>
    <dbReference type="EnsemblBacteria" id="ACU07913">
        <property type="protein sequence ID" value="ACU07913"/>
        <property type="gene ID" value="FIC_01465"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01465"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_0_10"/>
    <dbReference type="OMA" id="PVKQIWK"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="262"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACU07913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="640" mass="73159" checksum="27C4C73937BA379C" modified="2009-09-22" version="1">MISKATIDKIFSTIRVEEIIGEYVQLKRAGSNFKGLSPFHDEKTPSFVVSPSKQIWKDFSSGKGGTAISFLMEIESFTYPEALRHAAKKYGIEIEEDKRELTVEEKQSQTDKEVLYKIHEIANSFFQEQLETEEGRAIGYSYFKERDLRDDIISKFQLGYAPEQKDAFTSFAIDKGYSKEILEKSGLSIYPENAPNGIDRFRERVIFPIHSFSGRVLGFGGRILRNNVKTAKYLNSPETEIYHKSQVLYGLNQSKQAISKNNLCLLVEGYMDVIALHQAGIEHVVSSSGTALTVEQIKLIKRLTENVTILFDGDAAGIKASFRSIDMLLSESMNIRILLFPDGDDPDSFARKHPQDFVERFISTEAKDFIEFKAEVLLKEAGGDPAKKAEAIRDIVKSVAFVQNALKQEVYLKEVSTKFGLSEQSLFNELNVQQQMRKQQVSPQTRKEQETPQKLQVVPENTVTIDPLLVLEEKLVELMLKYGDRVVDRVDEENNGYQITVIEEIIGHLEEDQCEIQSPLNLKIIGEIKQGIDENELRAGNFFMTLLDENISGKVADAFVEPYETSDWGKHQIFFSSEEEVVPKLVQDVIFRHKREYIMKIIRDLKLALTDSENNDETYKKIITLTHLRKELDEKLFRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6C0</accession>
    <name>C6X6C0_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU07958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015806243.1">
        <property type="nucleotide sequence ID" value="NC_013062.1"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01511"/>
    <dbReference type="EnsemblBacteria" id="ACU07958">
        <property type="protein sequence ID" value="ACU07958"/>
        <property type="gene ID" value="FIC_01511"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01511"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_11_10"/>
    <dbReference type="OMA" id="YWLYFVT"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU07958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="475" mass="54154" checksum="202AC46350E37A4A" modified="2009-09-22" version="1">MKIFLTGATGYIGKRLLIQLLEEGHTVVCSVRDQKRFGTKLYGKHLNQIEIVENDFLDESTLTNIPVDIDAAYYLIHSMSSGEGDFQQKEKASADHFRKALEKTSVRQVIFLTGIINTEKLSKHLQSRKNVEDALKSENYALTNLRAGIVVGSGSASFEIIRDLVEKLPVMVAPKWLSTRCQPIAIRNVIQFLVGVLAKESTFNNNYDIAGKDILTYKQMLLQYAEVRGLKRGIFEVPVMTPKLSAYWLYFITSTSYPLAKNLVDSMKIDVIAQPNDLAENLGIKLFSYKEAINQAFDKIKQNNVLSSWYDSFSTQFHARNIWQYLEVPNKGCFKDTRKIKIADEEATLARIFSIGGNTGWYYADFLWKIRGFLDKLFGGVGIRRGRRNLNNLEAGDSVDFWRVLYASQEEKRLLLFAEMKVPGEAWLEFKIKDGFLHQEATFRPLGLSGRLYWYSVLPFHGLIFNGMLKKLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-22" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C6X6G4</accession>
    <name>C6X6G4_FLAB3</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FIC_01555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Flavobacteriaceae bacterium (strain 3519-10)</name>
        <dbReference type="NCBI Taxonomy" id="531844"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Flavobacteriia</taxon>
            <taxon>Flavobacteriales</taxon>
            <taxon>Flavobacteriaceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="Extremophiles" volume="12" first="713" last="717">
            <title>A bacterial ice-binding protein from the Vostok ice core.</title>
            <authorList>
                <person name="Raymond J.A."/>
                <person name="Christner B.C."/>
                <person name="Schuster S.C."/>
            </authorList>
            <dbReference type="PubMed" id="18622572"/>
            <dbReference type="DOI" id="10.1007/s00792-008-0178-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3519-10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001673">
        <property type="protein sequence ID" value="ACU08002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="531844.FIC_01555"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACU08002">
        <property type="protein sequence ID" value="ACU08002"/>
        <property type="gene ID" value="FIC_01555"/>
    </dbReference>
    <dbReference type="KEGG" id="fba:FIC_01555"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_3_10"/>
    <dbReference type="OMA" id="DADDAWH"/>
    <dbReference type="Proteomes" id="UP000001512">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACU08002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001512"/>
        </source>
    </evidence>
    <sequence length="268" mass="30570" checksum="B500C9F62B3385D5" modified="2009-09-22" version="1">MISVIIPVFNAEKSIEKTLASVKNQTWKGRFEIIMVNDGSTDGSVGVIENFKRKNPGMDITLVHQENLGVSSARNAAMKLAKGEFIALLDADDEWLPEKTARQMHFLTDSARNIDLLACARLNQPLLFPYRADENGLAEITFRKLMLRNEAPTPTVIFKAKVLQNTGIYMEDQRYAEDLNYWLRISENNSMFILNEGLVIAGGGKRSFGVSGLSANLSEMEKGFQQNLKQMLDSKRINQTEYIAYFIFYKFKYILRLCRNQYLKMLAK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>